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Aliases for FSTL5 Gene

Aliases for FSTL5 Gene

  • Follistatin-Like 5 2 3
  • Follistatin-Like Protein 5 4
  • KIAA1263 4

External Ids for FSTL5 Gene

Summaries for FSTL5 Gene

GeneCards Summary for FSTL5 Gene

FSTL5 (Follistatin-Like 5) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FSTL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL5 Gene

Genomics for FSTL5 Gene

Genomic Location for FSTL5 Gene

Start:
161,383,892 bp from pter
End:
162,164,035 bp from pter
Size:
780,144 bases
Orientation:
Minus strand

Genomic View for FSTL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FSTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL5 Gene

Regulatory Elements for FSTL5 Gene

Proteins for FSTL5 Gene

  • Protein details for FSTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N475-FSTL5_HUMAN
    Recommended name:
    Follistatin-related protein 5
    Protein Accession:
    Q8N475
    Secondary Accessions:
    • E9PCP6
    • Q9NSW7
    • Q9ULF7

    Protein attributes for FSTL5 Gene

    Size:
    847 amino acids
    Molecular mass:
    95751 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86577.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FSTL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSTL5 Gene

Proteomics data for FSTL5 Gene at MOPED

Post-translational modifications for FSTL5 Gene

  • Glycosylation at Asn318 and Asn394

Other Protein References for FSTL5 Gene

No data available for DME Specific Peptides for FSTL5 Gene

Domains for FSTL5 Gene

Gene Families for FSTL5 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • EFHAND :EF-hand domain containing

Suggested Antigen Peptide Sequences for FSTL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N475

UniProtKB/Swiss-Prot:

FSTL5_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • Q8N475
  • Contains 2 Ig-like (immunoglobulin-like) domains.:
    • Q8N475
  • Contains 1 Kazal-like domain.:
    • Q8N475
genes like me logo Genes that share domains with FSTL5: view

Function for FSTL5 Gene

Gene Ontology (GO) - Molecular Function for FSTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with FSTL5: view

Phenotypes for FSTL5 Gene

genes like me logo Genes that share phenotypes with FSTL5: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FSTL5 Gene

Localization for FSTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSTL5 Gene COMPARTMENTS Subcellular localization image for FSTL5 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
plasma membrane 2
cytosol 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FSTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FSTL5: view

Pathways for FSTL5 Gene

SuperPathways for FSTL5 Gene

No Data Available

Interacting Proteins for FSTL5 Gene

Gene Ontology (GO) - Biological Process for FSTL5 Gene

None

No data available for Pathways by source for FSTL5 Gene

Transcripts for FSTL5 Gene

mRNA/cDNA for FSTL5 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSTL5 Gene

Follistatin-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:

Relevant External Links for FSTL5 Gene

GeneLoc Exon Structure for
FSTL5
ECgene alternative splicing isoforms for
FSTL5

Expression for FSTL5 Gene

mRNA expression in normal human tissues for FSTL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSTL5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (18.3) and Brain - Cerebellum (11.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FSTL5 Gene

SOURCE GeneReport for Unigene cluster for FSTL5 Gene Hs.32452

genes like me logo Genes that share expressions with FSTL5: view

No data available for mRNA Expression by UniProt/SwissProt for FSTL5 Gene

Orthologs for FSTL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSTL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSTL5 35
  • 99.42 (n)
  • 99.14 (a)
FSTL5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
FSTL5 35
  • 90.78 (n)
  • 93.5 (a)
dog
(Canis familiaris)
Mammalia FSTL5 35
  • 92.83 (n)
  • 95.39 (a)
FSTL5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fstl5 35
  • 87.23 (n)
  • 91.25 (a)
Fstl5 16
Fstl5 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FSTL5 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSTL5 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fstl5 35
  • 87.67 (n)
  • 91.13 (a)
chicken
(Gallus gallus)
Aves FSTL5 35
  • 80.79 (n)
  • 84.5 (a)
FSTL5 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
FSTL5 36
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fstl5 35
  • 74.53 (n)
  • 77.61 (a)
zebrafish
(Danio rerio)
Actinopterygii fstl5 35
  • 66.31 (n)
  • 68.96 (a)
fstl5 36
  • 69 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for FSTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSTL5 Gene

ENSEMBL:
Gene Tree for FSTL5 (if available)
TreeFam:
Gene Tree for FSTL5 (if available)

Paralogs for FSTL5 Gene

Paralogs for FSTL5 Gene

Selected SIMAP similar genes for FSTL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FSTL5: view

Variants for FSTL5 Gene

Sequence variations from dbSNP and Humsavar for FSTL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs45426 -- 161,972,951(+) TCTAT(G/T)TTTCA intron-variant
rs165518 -- 161,819,085(-) CCATA(A/G)GCATC intron-variant
rs183095 -- 161,833,244(-) actgt(C/G)tctca intron-variant
rs359117 -- 161,847,786(+) aatcc(A/G)aggac intron-variant
rs359118 -- 161,846,822(+) CAGTC(C/T)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSTL5 Gene

Variant ID Type Subtype PubMed ID
nsv830133 CNV Gain 17160897
nsv881448 CNV Gain 21882294
nsv881274 CNV Loss 21882294
nsv880637 CNV Loss 21882294
nsv830134 CNV Gain 17160897
dgv5806n71 CNV Loss 21882294
esv273501 CNV Insertion 20981092
esv268859 CNV Insertion 20981092
dgv5807n71 CNV Loss 21882294
nsv880876 CNV Loss 21882294
nsv515994 CNV Loss 19592680
dgv1708e1 CNV Complex 17122850
nsv830135 CNV Loss 17160897
esv2672584 CNV Deletion 23128226
esv2728642 CNV Deletion 23290073
esv2663721 CNV Deletion 23128226
nsv292248 CNV Loss 16902084
nsv461811 CNV Loss 19166990
dgv5808n71 CNV Loss 21882294
dgv5809n71 CNV Loss 21882294
nsv880555 CNV Loss 21882294
nsv880988 CNV Gain 21882294
dgv5810n71 CNV Loss 21882294
esv2728643 CNV Deletion 23290073
esv2728644 CNV Deletion 23290073
nsv292893 CNV Loss 16902084
nsv511256 CNV Gain 21212237
nsv10602 CNV Gain+Loss 18304495
nsv435798 CNV Deletion 17901297
dgv987e199 CNV Deletion 23128226
esv2666113 CNV Deletion 23128226
dgv131e180 CNV Gain 20482838
dgv905n67 CNV Loss 20364138
nsv821380 CNV Deletion 20802225
esv29667 CNV Gain 19812545
esv268143 CNV Insertion 20981092
dgv5811n71 CNV Loss 21882294
nsv880693 CNV Gain+Loss 21882294
nsv880955 CNV Loss 21882294
dgv5812n71 CNV Loss 21882294
nsv880421 CNV Loss 21882294
nsv461812 CNV Gain 19166990
nsv880480 CNV Loss 21882294
esv271675 CNV Insertion 20981092
nsv290897 CNV Insertion 16902084
nsv880583 CNV Loss 21882294
dgv5813n71 CNV Loss 21882294
nsv470092 CNV Loss 18288195
nsv881244 CNV Loss 21882294
dgv681n27 CNV Loss 19166990
nsv880621 CNV Loss 21882294
nsv461815 CNV Gain 19166990
nsv291231 CNV Loss 16902084
nsv289833 CNV Insertion 16902084
nsv482919 CNV Loss 15286789
dgv1709e1 CNV Complex 17122850
nsv881065 CNV Loss 21882294
esv2728645 CNV Deletion 23290073
esv1964832 CNV Deletion 18987734
esv2728646 CNV Deletion 23290073
esv4615 CNV Deletion 18987735
esv993795 CNV Deletion 20482838
dgv177n6 CNV Loss 16902084
nsv461819 CNV Loss 19166990
dgv5814n71 CNV Loss 21882294
dgv5815n71 CNV Loss 21882294
dgv988e199 CNV Deletion 23128226
nsv880594 CNV Loss 21882294
nsv435789 CNV Deletion 17901297
esv2671308 CNV Deletion 23128226
nsv525141 CNV Loss 19592680
nsv822803 CNV Gain 20364138
nsv881234 CNV Loss 21882294
esv3010 CNV Deletion 18987735
esv6138 CNV Loss 19470904
esv2728647 CNV Deletion 23290073

Relevant External Links for FSTL5 Gene

HapMap Linkage Disequilibrium report
FSTL5
Human Gene Mutation Database (HGMD)
FSTL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL5 Gene

Disorders for FSTL5 Gene

Relevant External Links for FSTL5

Genetic Association Database (GAD)
FSTL5
Human Genome Epidemiology (HuGE) Navigator
FSTL5
genes like me logo Genes that share disorders with FSTL5: view

No data available for UniProtKB/Swiss-Prot for FSTL5 Gene

Publications for FSTL5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution. (PMID: 15527507) Glusman G. … Rowen L. (BMC Evol. Biol. 2004) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 48

Products for FSTL5 Gene

Sources for FSTL5 Gene

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