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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FSTL5 Gene

protein-coding   GIFtS: 47
GCID: GC04M162305

follistatin-like 5

 Explore 1 disease affiliated with
FSTL5 via our new
 Human Malady Compendium 
Biological research products
for FSTL5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Follistatin-Like 51 2
KIAA12631 3
Follistatin-Like Protein 52 3
DKFZp566D2341
Follistatin-Related Protein 52

External Ids:    HGNC: 213861   Entrez Gene: 568842   Ensembl: ENSG000001688437   UniProtKB: Q8N4753   

Export aliases for FSTL5 gene to outside databases

Previous GC identifers: GC04M162874 GC04M162662 GC04M162524 GC04M158057


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FSTL5 gene promoter:
         GR   GR-beta   FOXD3   C/EBPalpha   CHOP-10   MZF-1   HEN1   AREB6   GR-alpha   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSTL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for FSTL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSTL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.2   HGNC cytogenetic band: 4q32.3

FSTL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSTL5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M162305:  view genomic region     (about GC identifiers)

Start:
162,305,049 bp from pter      End:
163,085,187 bp from pter
Size:
780,139 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FSTL5_HUMAN, Q8N475 (See protein sequence)
Recommended Name: Follistatin-related protein 5 precursor  
Size: 847 amino acids; 95751 Da
Subcellular location: Secreted (Probable)
Sequence caution: Sequence=BAA86577.1; Type=Erroneous initiation;
Secondary accessions: E9PCP6 Q9NSW7 Q9ULF7
Alternative splicing: 3 isoforms:  Q8N475-1   Q8N475-2   Q8N475-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FSTL5: NX_Q8N475

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N475

  • FSTL5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001121899.1  NP_001121900.1  NP_064501.2  

    ENSEMBL proteins: 
     ENSP00000305334   ENSP00000368462   ENSP00000389270   ENSP00000440409  

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    Uscn Proteins for FSTL5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    FSTL5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FSTL5 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR003598 Ig_sub2
     IPR002350 Prot_inh_Kazal
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q8N475

    ProtoNet protein and cluster: Q8N475

    3 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: FSTL5_HUMAN, Q8N475
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains
    Similarity: Contains 1 Kazal-like domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-3938 hsa-miR-302d hsa-miR-520e hsa-miR-4328 hsa-miR-301a hsa-miR-519a hsa-miR-10b* hsa-miR-183*
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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--


    FSTL5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FSTL5:
     Decreased viability of wild-ty 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSTL5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FSTL5
    Search CenterWatch for drugs/clinical trials and news about FSTL5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for FSTL5 gene (3 alternative transcripts): 
    NM_001128427.2  NM_001128428.2  NM_020116.4  

    Unigene Cluster for FSTL5:

    Follistatin-like 5
    Hs.32452  [show with all ESTs]
    Unigene Representative Sequence: BC036502
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306100(uc003iqi.3 uc003iqh.3 uc010iqv.3) ENST00000379164
    ENST00000427802 ENST00000511999 ENST00000511170 ENST00000536695

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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate FSTL5 (see all 43):
    hsa-miR-3938 hsa-miR-302d hsa-miR-520e hsa-miR-4328 hsa-miR-301a hsa-miR-519a hsa-miR-10b* hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidFSTL5 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FSTL5 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AB033089.1 AK315152.1 AL137695.1 BC036502.2 BC036945.2 BC073978.1 

    5 DOTS entries:

    DT.210937  DT.100017182  DT.40263411  DT.121251866  DT.91689257 

    5 AceView cDNA sequences:

    AL712079 BX645780 BX953958 BX954109 BX490849 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FSTL5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                
    SP2:                                                                                                


    ECgene alternative splicing isoforms for FSTL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FSTL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGATGCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    FSTL5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BoneMaxillary ProcessBone
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Dorsal forebrain-like neurons (Generation of midbra...)Brain

    See FSTL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FSTL5

    SOURCE GeneReport for Unigene cluster: Hs.32452
        SABiosciences Custom PCR Arrays for FSTL5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FSTL5 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FSTL51 follistatin-like 5 80.81(n)
    84.52(a)
      428726  XM_426284.3  XP_426284.3 
    lizard
    (Anolis carolinensis)
    Reptilia C5H0X9_ANOCA6
    --
    --
    81(a)
    80(a)
    1 ↔ many
    1 ↔ many
    5(127156207-127156788)
    5(126883239-126883484)
    zebrafish
    (Danio rerio)
    Actinopterygii fstl51 follistatin-like 5 66.39(n)
    69.19(a)
      566192  NM_001031842.1  NP_001027012.1 
    honey bee
    (Apis mellifera)
    Insecta MAHYA6
    --
    32(a)
    1 → many
    Group12.10(537977-542462)


    ENSEMBL Gene Tree for FSTL5 (if available)
    TreeFam Gene Tree for FSTL5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FSTL5 gene
    FSTL12  FSTL42  
    3 SIMAP similar genes for FSTL5 using alignment to 2 protein entries:     FSTL5_HUMAN (see all proteins):
    DKFZp566D234    FSTL4    AGRN

    FSTL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 18 variations for FSTL5
         12 CNVs: 64000 3522 23110 0053 92501 92500 3523 23047 51316 31202 32663 53153
         6 Indels: 92502 41331 62276 12573 42514 80540
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FSTL5 for disorders           About GeneDecksing

    1 disease for FSTL5:    About MalaCards
    medulloblastoma

    Human Genome Epidemiology (HuGE) Navigator: FSTL5 (1 document)

    Export disorders for FSTL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FSTL5 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with FSTL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution. (PubMed id 15527507)1, 3 Glusman G.... Rowen L. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. FSTL5 is a marker of poor prognosis in non-WNT/non-SH H medulloblastoma. (PubMed id 21911727)1 Remke M....Pfister S.M. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1 Croteau-Chonka D.C....Mohlke K.L. (2010)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56884 HGNC: 21386 AceView: FSTL5.1 Ensembl:ENSG00000168843 euGenes: HUgn56884
    ECgene: FSTL5 H-InvDB: FSTL5

    (According to HUGE)
    About This Section
    HUGE: KIAA1263

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FSTL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FSTL5 gene:
    Search GeneIP for patents involving FSTL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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