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Aliases for FSTL5 Gene

Aliases for FSTL5 Gene

  • Follistatin Like 5 2 3 5
  • Follistatin-Like Protein 5 4
  • Follistatin-Like 5 2
  • KIAA1263 4

External Ids for FSTL5 Gene

Previous GeneCards Identifiers for FSTL5 Gene

  • GC04M162874
  • GC04M162662
  • GC04M162524
  • GC04M162305
  • GC04M158057

Summaries for FSTL5 Gene

GeneCards Summary for FSTL5 Gene

FSTL5 (Follistatin Like 5) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FSTL4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL5 Gene

Genomics for FSTL5 Gene

Regulatory Elements for FSTL5 Gene

Enhancers for FSTL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FSTL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FSTL5 Gene

Chromosome:
4
Start:
161,383,892 bp from pter
End:
162,164,035 bp from pter
Size:
780,144 bases
Orientation:
Minus strand

Genomic View for FSTL5 Gene

Genes around FSTL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSTL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL5 Gene

Proteins for FSTL5 Gene

  • Protein details for FSTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N475-FSTL5_HUMAN
    Recommended name:
    Follistatin-related protein 5
    Protein Accession:
    Q8N475
    Secondary Accessions:
    • E9PCP6
    • Q9NSW7
    • Q9ULF7

    Protein attributes for FSTL5 Gene

    Size:
    847 amino acids
    Molecular mass:
    95751 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86577.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FSTL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSTL5 Gene

Post-translational modifications for FSTL5 Gene

  • Glycosylation at Asn 318 and Asn 394
  • Modification sites at PhosphoSitePlus

Other Protein References for FSTL5 Gene

No data available for DME Specific Peptides for FSTL5 Gene

Domains & Families for FSTL5 Gene

Suggested Antigen Peptide Sequences for FSTL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N475

UniProtKB/Swiss-Prot:

FSTL5_HUMAN :
  • Contains 2 EF-hand domains.
Domain:
  • Contains 2 EF-hand domains.
  • Contains 2 Ig-like (immunoglobulin-like) domains.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with FSTL5: view

Function for FSTL5 Gene

Gene Ontology (GO) - Molecular Function for FSTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with FSTL5: view
genes like me logo Genes that share phenotypes with FSTL5: view

Animal Model Products

CRISPR Products

miRNA for FSTL5 Gene

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSTL5 Gene

Localization for FSTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSTL5 Gene COMPARTMENTS Subcellular localization image for FSTL5 gene
Compartment Confidence
extracellular 4
cytosol 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FSTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FSTL5: view

Pathways & Interactions for FSTL5 Gene

SuperPathways for FSTL5 Gene

No Data Available

Interacting Proteins for FSTL5 Gene

Gene Ontology (GO) - Biological Process for FSTL5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FSTL5 Gene

Drugs & Compounds for FSTL5 Gene

No Compound Related Data Available

Transcripts for FSTL5 Gene

mRNA/cDNA for FSTL5 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSTL5 Gene

Follistatin-like 5:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:

Relevant External Links for FSTL5 Gene

GeneLoc Exon Structure for
FSTL5
ECgene alternative splicing isoforms for
FSTL5

Expression for FSTL5 Gene

mRNA expression in normal human tissues for FSTL5 Gene

mRNA differential expression in normal tissues according to GTEx for FSTL5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x18.3) and Brain - Cerebellum (x11.3).

Protein differential expression in normal tissues from HIPED for FSTL5 Gene

This gene is overexpressed in Vitreous humor (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FSTL5 Gene



Protein tissue co-expression partners for FSTL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FSTL5 Gene:

FSTL5

SOURCE GeneReport for Unigene cluster for FSTL5 Gene:

Hs.32452
genes like me logo Genes that share expression patterns with FSTL5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FSTL5 Gene

Orthologs for FSTL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSTL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FSTL5 34
  • 90.78 (n)
  • 93.5 (a)
-- 35
  • 90 (a)
OneToMany
-- 35
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FSTL5 34
  • 92.83 (n)
  • 95.39 (a)
FSTL5 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fstl5 34
  • 87.23 (n)
  • 91.25 (a)
Fstl5 16
Fstl5 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fstl5 34
  • 87.67 (n)
  • 91.13 (a)
oppossum
(Monodelphis domestica)
Mammalia FSTL5 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSTL5 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FSTL5 35
  • 99 (a)
OneToOne
FSTL5 34
  • 99.42 (n)
  • 99.14 (a)
chicken
(Gallus gallus)
Aves FSTL5 34
  • 80.79 (n)
  • 84.5 (a)
FSTL5 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
OneToMany
FSTL5 35
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fstl5 34
  • 74.53 (n)
  • 77.61 (a)
zebrafish
(Danio rerio)
Actinopterygii fstl5 34
  • 66.31 (n)
  • 68.96 (a)
fstl5 35
  • 69 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for FSTL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSTL5 Gene

ENSEMBL:
Gene Tree for FSTL5 (if available)
TreeFam:
Gene Tree for FSTL5 (if available)

Paralogs for FSTL5 Gene

Paralogs for FSTL5 Gene

(3) SIMAP similar genes for FSTL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FSTL5: view

Variants for FSTL5 Gene

Sequence variations from dbSNP and Humsavar for FSTL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036135 A colorectal cancer sample
rs3749598 - 161,386,160(-) TTAAT(A/G/T)ATGTG reference, missense
rs17040982 - 161,385,848(+) GTCCT(C/T)GGAAG reference, missense
rs370921 -- 161,981,266(-) CATGC(C/T)AGTGA intron-variant
rs388838 -- 161,978,236(+) TGTAT(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSTL5 Gene

Variant ID Type Subtype PubMed ID
dgv131e180 CNV gain 20482838
dgv1538e212 CNV loss 25503493
dgv177n6 CNV deletion 16902084
dgv2925n106 CNV deletion 24896259
dgv2926n106 CNV deletion 24896259
dgv2927n106 CNV deletion 24896259
dgv340e215 CNV deletion 23714750
dgv5454n100 CNV gain 25217958
dgv5457n100 CNV gain 25217958
dgv681n27 CNV loss 19166990
dgv905n67 CNV loss 20364138
dgv9344n54 CNV gain 21841781
dgv9357n54 CNV loss 21841781
dgv9358n54 CNV loss 21841781
dgv9359n54 CNV loss 21841781
dgv9360n54 CNV loss 21841781
dgv9361n54 CNV loss 21841781
dgv9362n54 CNV loss 21841781
dgv987e199 CNV deletion 23128226
dgv988e199 CNV deletion 23128226
esv1964832 CNV deletion 18987734
esv2663721 CNV deletion 23128226
esv2666113 CNV deletion 23128226
esv2671308 CNV deletion 23128226
esv2672584 CNV deletion 23128226
esv2728642 CNV deletion 23290073
esv2728643 CNV deletion 23290073
esv2728644 CNV deletion 23290073
esv2728645 CNV deletion 23290073
esv2728646 CNV deletion 23290073
esv2728647 CNV deletion 23290073
esv2759296 CNV loss 17122850
esv2759297 CNV loss 17122850
esv29667 CNV gain 19812545
esv3010 CNV loss 18987735
esv3303864 CNV mobile element insertion 20981092
esv3304581 CNV mobile element insertion 20981092
esv3307401 CNV mobile element insertion 20981092
esv3309228 CNV mobile element insertion 20981092
esv3354930 CNV insertion 20981092
esv3378149 CNV insertion 20981092
esv3415697 CNV insertion 20981092
esv3439685 CNV insertion 20981092
esv3564886 CNV deletion 23714750
esv3564887 CNV deletion 23714750
esv3564892 CNV deletion 23714750
esv3569778 CNV loss 25503493
esv3569779 CNV loss 25503493
esv3575786 CNV gain 25503493
esv3602905 CNV gain 21293372
esv3602910 CNV loss 21293372
esv3602911 CNV loss 21293372
esv3602915 CNV loss 21293372
esv3602917 CNV loss 21293372
esv3602918 CNV loss 21293372
esv3602920 CNV loss 21293372
esv3602922 CNV loss 21293372
esv3602923 CNV loss 21293372
esv3602924 CNV loss 21293372
esv3602925 CNV gain 21293372
esv3602926 CNV gain 21293372
esv3894063 CNV loss 25118596
esv4615 CNV loss 18987735
esv6138 CNV loss 19470904
esv993795 CNV deletion 20482838
nsv1015273 CNV gain 25217958
nsv1015505 CNV gain 25217958
nsv1022409 CNV loss 25217958
nsv1030099 CNV gain 25217958
nsv1031902 CNV gain 25217958
nsv1032175 CNV gain 25217958
nsv10602 CNV gain+loss 18304495
nsv1128106 CNV deletion 24896259
nsv1139820 CNV duplication 24896259
nsv1161168 CNV duplication 26073780
nsv289833 CNV insertion 16902084
nsv290897 CNV insertion 16902084
nsv291231 CNV deletion 16902084
nsv292248 CNV deletion 16902084
nsv292893 CNV deletion 16902084
nsv435789 CNV deletion 17901297
nsv435798 CNV deletion 17901297
nsv461811 CNV loss 19166990
nsv461812 CNV gain 19166990
nsv461815 CNV gain 19166990
nsv461819 CNV loss 19166990
nsv470092 CNV loss 18288195
nsv475804 CNV novel sequence insertion 20440878
nsv477814 CNV novel sequence insertion 20440878
nsv482919 CNV loss 15286789
nsv511256 CNV gain 21212237
nsv515994 CNV loss 19592680
nsv525141 CNV loss 19592680
nsv595952 CNV loss 21841781
nsv595953 CNV loss 21841781
nsv595954 CNV loss 21841781
nsv595958 CNV loss 21841781
nsv595981 CNV loss 21841781
nsv595986 CNV gain 21841781
nsv595989 CNV gain 21841781
nsv595990 CNV loss 21841781
nsv595991 CNV loss 21841781
nsv595992 CNV loss 21841781
nsv595993 CNV loss 21841781
nsv821380 CNV deletion 20802225
nsv822803 CNV gain 20364138
nsv830133 CNV gain 17160897
nsv830134 CNV gain 17160897
nsv830135 CNV loss 17160897
nsv956375 CNV deletion 24416366
nsv958225 CNV deletion 24416366

Variation tolerance for FSTL5 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSTL5 Gene

Human Gene Mutation Database (HGMD)
FSTL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSTL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL5 Gene

Disorders for FSTL5 Gene

Relevant External Links for FSTL5

Genetic Association Database (GAD)
FSTL5
Human Genome Epidemiology (HuGE) Navigator
FSTL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSTL5

No disorders were found for FSTL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSTL5 Gene

Publications for FSTL5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 65
  2. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 46 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution. (PMID: 15527507) Glusman G. … Rowen L. (BMC Evol. Biol. 2004) 2 3 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for FSTL5 Gene

Sources for FSTL5 Gene

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