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Aliases for FSTL4 Gene

Aliases for FSTL4 Gene

  • Follistatin Like 4 2 3 5
  • Follistatin-Like Protein 4 4
  • Follistatin-Like 4 2
  • KIAA1061 4

External Ids for FSTL4 Gene

Previous GeneCards Identifiers for FSTL4 Gene

  • GC05M132609
  • GC05M132560
  • GC05M127723

Summaries for FSTL4 Gene

GeneCards Summary for FSTL4 Gene

FSTL4 (Follistatin Like 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FSTL5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL4 Gene

Genomics for FSTL4 Gene

Regulatory Elements for FSTL4 Gene

Enhancers for FSTL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F133530 0.6 ENCODE 27 +310.7 310706 0.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FSTL4 RAD50 AFF4 ZCCHC10 GC05P133540 PIR50619
GH05F133602 0.6 Ensembl 24.3 +239.1 239051 0.6 GLIS1 JUN REST FSTL4 GC05M133626 ENSG00000279197
GH05F133831 0.2 ENCODE 0.4 +9.9 9922 1.1 GLIS1 FSTL4 LOC105379179
GH05F133847 0.2 Ensembl 0.4 -5.2 -5235 0.2 NFYB FSTL4 WSPAR
GH05F133848 0.2 ENCODE 0.4 -6.4 -6389 0.1 ZNF687 MNT ZIC2 E2F1 CTBP1 ZNF341 MYC ZNF423 TCF7L2 FSTL4 WSPAR
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FSTL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FSTL4 Gene

133,194,827 bp from pter
133,842,066 bp from pter
647,240 bases
Minus strand

Genomic View for FSTL4 Gene

Genes around FSTL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSTL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSTL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL4 Gene

Proteins for FSTL4 Gene

  • Protein details for FSTL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Follistatin-related protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8TBU0
    • Q9UPU1

    Protein attributes for FSTL4 Gene

    842 amino acids
    Molecular mass:
    93096 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FSTL4 Gene


neXtProt entry for FSTL4 Gene

Post-translational modifications for FSTL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSTL4 Gene

No data available for DME Specific Peptides for FSTL4 Gene

Domains & Families for FSTL4 Gene

Suggested Antigen Peptide Sequences for FSTL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EF-hand domain.
  • Contains 1 EF-hand domain.
  • Contains 2 Ig-like (immunoglobulin-like) domains.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with FSTL4: view

Function for FSTL4 Gene

Gene Ontology (GO) - Molecular Function for FSTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0048403 brain-derived neurotrophic factor binding IEA --
genes like me logo Genes that share ontologies with FSTL4: view

Phenotypes for FSTL4 Gene

MGI mutant phenotypes for FSTL4:
inferred from 1 alleles
GenomeRNAi human phenotypes for FSTL4:
genes like me logo Genes that share phenotypes with FSTL4: view

Animal Models for FSTL4 Gene

MGI Knock Outs for FSTL4:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FSTL4 Gene

Localization for FSTL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL4 Gene


Subcellular locations from

Jensen Localization Image for FSTL4 Gene COMPARTMENTS Subcellular localization image for FSTL4 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FSTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with FSTL4: view

Pathways & Interactions for FSTL4 Gene

SuperPathways for FSTL4 Gene

No Data Available

Interacting Proteins for FSTL4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000265342 Q6MZW2-FSTL4_HUMAN for FSTL4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FSTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031549 negative regulation of brain-derived neurotrophic factor receptor signaling pathway IEA --
GO:0048670 regulation of collateral sprouting IEA --
GO:0048671 negative regulation of collateral sprouting IEA --
GO:0061000 negative regulation of dendritic spine development IEA --
genes like me logo Genes that share ontologies with FSTL4: view

No data available for Pathways by source and SIGNOR curated interactions for FSTL4 Gene

Transcripts for FSTL4 Gene

Unigene Clusters for FSTL4 Gene

Follistatin-like 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL4 Gene

No ASD Table

Relevant External Links for FSTL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSTL4 Gene

mRNA expression in normal human tissues for FSTL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSTL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.1), Brain - Cortex (x5.6), and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for FSTL4 Gene

This gene is overexpressed in Vitreous humor (35.5), Platelet (13.2), Plasma (7.1), and Cerebrospinal fluid (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FSTL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FSTL4 Gene:


SOURCE GeneReport for Unigene cluster for FSTL4 Gene:

genes like me logo Genes that share expression patterns with FSTL4: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FSTL4 Gene

Orthologs for FSTL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSTL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FSTL4 34 35
  • 99.13 (n)
(Bos Taurus)
Mammalia FSTL4 34 35
  • 86.03 (n)
(Canis familiaris)
Mammalia FSTL4 34 35
  • 85.67 (n)
(Mus musculus)
Mammalia Fstl4 34 16 35
  • 84.15 (n)
(Rattus norvegicus)
Mammalia Fstl4 34
  • 84.01 (n)
(Monodelphis domestica)
Mammalia FSTL4 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia FSTL4 35
  • 70 (a)
(Gallus gallus)
Aves FSTL4 34 35
  • 71.37 (n)
(Anolis carolinensis)
Reptilia FSTL4 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fstl4 34
  • 65.31 (n)
(Danio rerio)
Actinopterygii fstl4 34 35
  • 61.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
Species where no ortholog for FSTL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSTL4 Gene

Gene Tree for FSTL4 (if available)
Gene Tree for FSTL4 (if available)

Paralogs for FSTL4 Gene

Paralogs for FSTL4 Gene

(6) SIMAP similar genes for FSTL4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FSTL4: view

Variants for FSTL4 Gene

Sequence variations from dbSNP and Humsavar for FSTL4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1001559 -- 133,762,514(+) ATCAG(G/T)TGGAA intron-variant
rs10035483 -- 133,338,866(+) TCTCT(C/T)AGGGT intron-variant
rs10035499 -- 133,824,455(+) aagca(C/G)acaaa intron-variant
rs10035595 -- 133,494,173(+) cacac(C/T)tacTG intron-variant
rs10035597 -- 133,494,179(+) TACTG(C/T)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSTL4 Gene

Variant ID Type Subtype PubMed ID
dgv151e180 CNV deletion 20482838
dgv3175n106 CNV deletion 24896259
esv1621824 CNV insertion 17803354
esv2249045 CNV deletion 18987734
esv23506 CNV loss 19812545
esv2428690 CNV deletion 19546169
esv26142 CNV gain 19812545
esv2663891 CNV deletion 23128226
esv2664177 CNV deletion 23128226
esv2730797 CNV deletion 23290073
esv2730798 CNV deletion 23290073
esv2730799 CNV deletion 23290073
esv3184 CNV loss 18987735
esv3290495 CNV deletion 24192839
esv3305263 CNV mobile element insertion 20981092
esv3310091 CNV mobile element insertion 20981092
esv3410884 CNV insertion 20981092
esv3418349 CNV insertion 20981092
esv3437476 CNV insertion 20981092
esv3444849 CNV insertion 20981092
esv3566664 CNV deletion 23714750
esv3566665 CNV deletion 23714750
esv3566667 CNV deletion 23714750
esv3606817 CNV loss 21293372
esv3606820 CNV loss 21293372
esv3606822 CNV loss 21293372
esv3606824 CNV loss 21293372
esv3890741 CNV loss 25118596
esv8441 CNV loss 19470904
esv9191 CNV gain 19470904
nsv1017954 CNV loss 25217958
nsv1033112 CNV gain 25217958
nsv1131917 CNV deletion 24896259
nsv1146461 CNV deletion 26484159
nsv327378 CNV deletion 16902084
nsv327511 CNV deletion 16902084
nsv329127 CNV insertion 16902084
nsv436465 CNV deletion 17901297
nsv476686 CNV novel sequence insertion 20440878
nsv499700 CNV loss 21111241
nsv5005 CNV deletion 18451855
nsv5006 CNV deletion 18451855
nsv5007 CNV insertion 18451855
nsv507295 OTHER sequence alteration 20534489
nsv508379 CNV deletion 20534489
nsv511115 OTHER complex 20534489
nsv513262 CNV loss 21212237
nsv519514 CNV loss 19592680
nsv520869 CNV gain+loss 19592680
nsv599716 CNV gain 21841781
nsv599717 CNV loss 21841781
nsv599718 CNV loss 21841781

Variation tolerance for FSTL4 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSTL4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL4 Gene

Disorders for FSTL4 Gene

Relevant External Links for FSTL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FSTL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSTL4 Gene

Publications for FSTL4 Gene

  1. An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution. (PMID: 15527507) Glusman G. … Rowen L. (BMC Evol. Biol. 2004) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits. (PMID: 22384028) Guo Y. … Thomas N.G. (PLoS ONE 2012) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64

Products for FSTL4 Gene

Sources for FSTL4 Gene

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