Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FSTL4 Gene

Aliases for FSTL4 Gene

  • Follistatin Like 4 2 3
  • Follistatin-Like 4 2 5
  • Follistatin-Like Protein 4 4
  • KIAA1061 4

External Ids for FSTL4 Gene

Previous GeneCards Identifiers for FSTL4 Gene

  • GC05M132609
  • GC05M132560
  • GC05M127723

Summaries for FSTL4 Gene

GeneCards Summary for FSTL4 Gene

FSTL4 (Follistatin Like 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FSTL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL4 Gene

Genomics for FSTL4 Gene

Regulatory Elements for FSTL4 Gene

Enhancers for FSTL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FSTL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FSTL4 Gene

133,194,827 bp from pter
133,842,066 bp from pter
647,240 bases
Minus strand

Genomic View for FSTL4 Gene

Genes around FSTL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSTL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSTL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL4 Gene

Proteins for FSTL4 Gene

  • Protein details for FSTL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Follistatin-related protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8TBU0
    • Q9UPU1

    Protein attributes for FSTL4 Gene

    842 amino acids
    Molecular mass:
    93096 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FSTL4 Gene


neXtProt entry for FSTL4 Gene

Proteomics data for FSTL4 Gene at MOPED

Post-translational modifications for FSTL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSTL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSTL4 Gene

Domains & Families for FSTL4 Gene

Suggested Antigen Peptide Sequences for FSTL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EF-hand domain.
  • Contains 1 EF-hand domain.
  • Contains 2 Ig-like (immunoglobulin-like) domains.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with FSTL4: view

Function for FSTL4 Gene

Phenotypes for FSTL4 Gene

MGI mutant phenotypes for FSTL4:
inferred from 1 alleles
GenomeRNAi human phenotypes for FSTL4:
genes like me logo Genes that share phenotypes with FSTL4: view

Animal Models for FSTL4 Gene

MGI Knock Outs for FSTL4:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FSTL4 Gene

Localization for FSTL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL4 Gene


Subcellular locations from

Jensen Localization Image for FSTL4 Gene COMPARTMENTS Subcellular localization image for FSTL4 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for FSTL4 Gene

Pathways & Interactions for FSTL4 Gene

SuperPathways for FSTL4 Gene

No Data Available

Interacting Proteins for FSTL4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000265342 for FSTL4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FSTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048671 negative regulation of collateral sprouting IEA --
genes like me logo Genes that share ontologies with FSTL4: view

No data available for Pathways by source and SIGNOR curated interactions for FSTL4 Gene

Drugs & Compounds for FSTL4 Gene

No Compound Related Data Available

Transcripts for FSTL4 Gene

Unigene Clusters for FSTL4 Gene

Follistatin-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL4 Gene

No ASD Table

Relevant External Links for FSTL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSTL4 Gene

mRNA expression in normal human tissues for FSTL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSTL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.1), Brain - Cortex (x5.6), and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for FSTL4 Gene

This gene is overexpressed in Vitreous humor (35.5), Platelet (13.2), Plasma (7.1), and Cerebrospinal fluid (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FSTL4 Gene

SOURCE GeneReport for Unigene cluster for FSTL4 Gene Hs.483390

genes like me logo Genes that share expression patterns with FSTL4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FSTL4 Gene

Orthologs for FSTL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSTL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FSTL4 35
  • 86.03 (n)
  • 85.63 (a)
FSTL4 36
  • 88 (a)
(Canis familiaris)
Mammalia FSTL4 35
  • 85.67 (n)
  • 84.8 (a)
FSTL4 36
  • 85 (a)
(Mus musculus)
Mammalia Fstl4 35
  • 84.15 (n)
  • 83.83 (a)
Fstl4 16
Fstl4 36
  • 84 (a)
(Pan troglodytes)
Mammalia FSTL4 35
  • 99.13 (n)
  • 99.29 (a)
FSTL4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fstl4 35
  • 84.01 (n)
  • 83.05 (a)
(Monodelphis domestica)
Mammalia FSTL4 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia FSTL4 36
  • 70 (a)
(Gallus gallus)
Aves FSTL4 35
  • 71.37 (n)
  • 69.12 (a)
FSTL4 36
  • 69 (a)
(Anolis carolinensis)
Reptilia FSTL4 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fstl4 35
  • 65.31 (n)
  • 64.89 (a)
(Danio rerio)
Actinopterygii fstl4 35
  • 61.74 (n)
  • 56.17 (a)
fstl4 36
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for FSTL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSTL4 Gene

Gene Tree for FSTL4 (if available)
Gene Tree for FSTL4 (if available)

Paralogs for FSTL4 Gene

Paralogs for FSTL4 Gene

(6) SIMAP similar genes for FSTL4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FSTL4: view

Variants for FSTL4 Gene

Sequence variations from dbSNP and Humsavar for FSTL4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17683306 - 133,316,589(+) GCAGA(A/C/G/T)GGGTC reference, missense
rs3749817 - 133,199,354(-) GCACA(C/T)GGAGC reference, missense
rs718410 -- 133,471,980(-) GAAAA(A/G)GCCCA intron-variant
rs720622 -- 133,200,346(-) GCCCC(C/T)ACATG intron-variant
rs720770 -- 133,701,768(-) CAAAC(A/G)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSTL4 Gene

Variant ID Type Subtype PubMed ID
esv26142 CNV Gain 19812545
nsv519514 CNV Loss 19592680
esv2730797 CNV Deletion 23290073
esv2730798 CNV Deletion 23290073
nsv327378 CNV Loss 16902084
nsv327511 CNV Loss 16902084
esv23506 CNV Loss 19812545
esv1621824 CNV Insertion 17803354
nsv329127 CNV Insertion 16902084
nsv520869 CNV Gain+Loss 19592680
esv271696 CNV Insertion 20981092
nsv5005 CNV Loss 18451855
esv9191 CNV Gain 19470904
nsv507295 CNV Insertion 20534489
esv2664177 CNV Deletion 23128226
nsv5006 CNV Loss 18451855
nsv5007 CNV Insertion 18451855
nsv511115 CNV Complex 20534489
nsv508379 CNV Loss 20534489
esv2428690 CNV Deletion 19546169
dgv151e180 CNV Deletion 20482838
nsv513262 CNV Loss 21212237
esv2249045 CNV Deletion 18987734
nsv436465 CNV Deletion 17901297
esv3184 CNV Deletion 18987735
esv2730799 CNV Deletion 23290073
esv2663891 CNV Deletion 23128226
nsv499700 CNV Loss 21111241
esv8441 CNV Loss 19470904
esv269541 CNV Insertion 20981092
esv274363 CNV Insertion 20981092

Variation tolerance for FSTL4 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSTL4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL4 Gene

Disorders for FSTL4 Gene

Relevant External Links for FSTL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FSTL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSTL4 Gene

Publications for FSTL4 Gene

  1. An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution. (PMID: 15527507) Glusman G. … Rowen L. (BMC Evol. Biol. 2004) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3
  3. A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits. (PMID: 22384028) Guo Y. … Thomas N.G. (PLoS ONE 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3

Products for FSTL4 Gene

Sources for FSTL4 Gene