Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FSTL3 Gene

protein-coding   GIFtS: 59
GCID: GC19P000676

Follistatin-Like 3 (Secreted Glycoprotein)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Follistatin-Like 3 (Secreted Glycoprotein)1 2     Follistatin-Related Protein1
FLRG2 3 5     FSRP2
Follistatin-Like Protein 32 3     Follistatin-Related Protein 32
Follistatin-Related Gene Protein2 3     

External Ids:    HGNC: 39731   Entrez Gene: 102722   Ensembl: ENSG000000704047   OMIM: 6053435   UniProtKB: O956333   

Export aliases for FSTL3 gene to outside databases

Previous GC identifers: GC19P000728 GC19P000616 GC19P000627 GC19P000446


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FSTL3 Gene:
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in
leukemogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FSTL3 Gene: 
FSTL3 (follistatin-like 3 (secreted glycoprotein)) is a protein-coding gene. Diseases associated with FSTL3 include blood disorders, and ovarian endometriosis, and among its related super-pathways are Signaling by Activin and Signaling by GPCR. GO annotations related to this gene include activin binding and fibronectin binding. An important paralog of this gene is FST.

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
Function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family,
such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more
effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc.
Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic
cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone
marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction
with MLLT10

Gene Wiki entry for FSTL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FSTL3 gene promoter:
         Max1   Lmo2   MyoD   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FSTL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FSTL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSTL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

FSTL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSTL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000676:  view genomic region     (about GC identifiers)

Start:
676,389 bp from pter      End:
683,392 bp from pter
Size:
7,004 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633 (See protein sequence)
Recommended Name: Follistatin-related protein 3 precursor  
Size: 263 amino acids; 27663 Da
Subunit: Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with
MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with
MSTN
Subcellular location: Isoform 1: Secreted
Subcellular location: Isoform 2: Nucleus. Note=Although alternative initiation has been demonstrated and resulted
in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at
Met-27 according to (PubMed:16150905)
3 PDB 3D structures from and Proteopedia for FSTL3:
2KCX (3D)        3B4V (3D)        3SEK (3D)    
Secondary accessions: A8K7E3
Alternative initiation: 2 isoforms:  O95633-1   O95633-2   

Explore the universe of human proteins at neXtProt for FSTL3: NX_O95633

Explore proteomics data for FSTL3 at MOPED 

FSTL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FSTL3 Protein Expression

REFSEQ proteins: NP_005851.1  
ENSEMBL proteins: 
 ENSP00000166139   ENSP00000468558   ENSP00000466383  
Reactome Protein details: O95633
Human Recombinant Protein Products for FSTL3: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for FSTL3 (Follistatin-related Gene Protein/FLRG)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for FSTL3
OriGene Protein Over-expression Lysate for FSTL3
OriGene MassSpec for FSTL3 
OriGene Custom Protein Services for FSTL3
GenScript Custom Purified and Recombinant Proteins Services for FSTL3
Novus Biologicals FSTL3 Protein
Novus Biologicals FSTL3 Lysate
Sino Biological Recombinant Protein for FSTL3
Sino Biological Cell Lysate for FSTL3 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for FSTL3 

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IDA16150905
GO:0005634nucleus IDA16150905
GO:0005794Golgi apparatus IEA--
GO:0030141secretory granule IEA--

FSTL3 for ontologies           About GeneDecksing



FSTL3 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for FSTL3 (Follistatin-related Gene Protein/FLRG)
Browse OriGene Antibodies
OriGene Custom Antibody Services for FSTL3
GenScript Custom Superior Antibodies Services for FSTL3
Novus Biologicals FSTL3 Antibody
Abcam antibodies for FSTL3
Cloud-Clone Corp. Antibodies for FSTL3 
Search ThermoFisher Antibodies for FSTL3
LSBio Antibodies in human, mouse, rat for FSTL3 

Assay Products for FSTL3: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for FSTL3
R&D Systems ELISAs for FSTL3 (Follistatin-related Gene Protein/FLRG)
GenScript Custom Assay Services for FSTL3
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for FSTL3 
Cloud-Clone Corp. CLIAs for FSTL3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR017878 TB_dom
 IPR002350 Kazal_dom
 IPR015369 Follistatin/Osteonectin_EGF
 IPR003645 Fol_N

Graphical View of Domain Structure for InterPro Entry O95633

ProtoNet protein and cluster: O95633

1 Blocks protein domain: IPB011497 Protease inhibitor

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
Similarity: Contains 2 follistatin-like domains
Similarity: Contains 2 Kazal-like domains
Similarity: Contains 1 TB (TGF-beta binding) domain


FSTL3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: FSTL3_HUMAN, O95633
Function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family,
such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more
effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc.
Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic
cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone
marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction
with MLLT10

     Genatlas biochemistry entry for FSTL3:
follistatin-like 3,secreted glycoprotein,expressed in a wide range of adult tissues,not detected in hematopoietic
cells except in patients with a B cell chronic leukemia and a translocation t(11;19)(q13;p13)

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001968fibronectin binding IPI16336961
GO:0005515protein binding IPI15574124
GO:0048185activin binding IPI12697670
     
FSTL3 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for FSTL3:
 Increased gamma-H2AX phosphory  Low eccentricity cells 

     7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fstl3):
 adipose tissue  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 
 muscle  no phenotypic analysis 

FSTL3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for FSTL3: Fstl3tm1Lex Fstl3tm1Alsc Fstl3tm1.1Sjl

   inGenious Targeting Laboratory - Custom generated mouse model solutions for FSTL3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FSTL3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FSTL3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FSTL3 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FSTL3
5 QIAGEN miScript miRNA Assays for microRNAs that regulate FSTL3:
hsa-miR-4316 hsa-miR-124 hsa-miR-506 hsa-miR-1827 hsa-miR-1910
SwitchGear 3'UTR luciferase reporter plasmidFSTL3 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for FSTL3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSTL3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for FSTL3
Sirion Biotech Customized adenovirus for overexpression of FSTL3

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for FSTL3 (see all 7)
OriGene ORF clones in mouse, rat for FSTL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FSTL3 (NM_005860)
Sino Biological Human cDNA Clone for FSTL3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSTL3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSTL3
Sirion Biotech Customized lentivirus for stable overexpression of FSTL3 
                     Customized lentivirus expression plasmids for stable overexpression of FSTL3 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for FSTL3
Search LifeMap BioReagents cell lines for FSTL3
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for FSTL3 About                                                                                                See pathways by source

SuperPathContained pathways About
1Signaling by NODAL
Signaling by Activin0.36
Antagonism of Activin by Follistatin0.33
2Signaling by GPCR
Signal Transduction0.55
3Signal transduction Activin A signaling regulation
Signal transduction Activin A signaling regulation0.31
4TGF-beta Signaling Pathway
TGF-beta Signaling Pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for FSTL3
    Signal transduction Activin A signaling regulation


1 GeneGo (Thomson Reuters) Pathway for FSTL3
    Signal transduction Activin A signaling regulation

1 Sino Biological Pathway for FSTL3 
    TGF-beta Signaling Pathway

3        Reactome Pathways for FSTL3
    Signaling by Activin
Signal Transduction
Antagonism of Activin by Follistatin



FSTL3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FSTL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for FSTL3 (O956331, 3 ENSP000001661394) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
ADAM12O43184-21, ENSP000003576684EBI-2625790,EBI-2625865 I2D: score=1 STRING: ENSP00000357668
FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
MSTNO147933, ENSP000002609504I2D: score=2 STRING: ENSP00000260950
INHBAP084763, ENSP000002422084I2D: score=1 STRING: ENSP00000242208
SMAD4Q134853, ENSP000003415514I2D: score=2 STRING: ENSP00000341551
About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001503ossification IEA--
GO:0001822kidney development IEA--
GO:0002244hematopoietic progenitor cell differentiation IDA15451575
GO:0006351transcription, DNA-dependent IEA--
GO:0006357regulation of transcription from RNA polymerase II promoter IDA11948405

FSTL3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FSTL3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FSTL3

2 Novoseek inferred chemical compound relationships for FSTL3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone 7.1 2 12970321 (1)
heparin 0 7 15471966 (4), 11956142 (1)

Search CenterWatch for drugs/clinical trials and news about FSTL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FSTL3 gene: 
NM_005860.2  

Unigene Cluster for FSTL3:

Follistatin-like 3 (secreted glycoprotein)
Hs.529038  [show with all ESTs]
Unigene Representative Sequence: NM_005860
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000166139(uc002lpk.1 uc010drt.1) ENST00000606071 ENST00000591552
ENST00000588773 ENST00000589185 ENST00000592058 ENST00000592947 ENST00000591573
ENST00000605925
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FSTL3
5 QIAGEN miScript miRNA Assays for microRNAs that regulate FSTL3:
hsa-miR-4316 hsa-miR-124 hsa-miR-506 hsa-miR-1827 hsa-miR-1910
SwitchGear 3'UTR luciferase reporter plasmidFSTL3 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for FSTL3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSTL3
Clone
Products:
     
OriGene clones in human, mouse for FSTL3 (see all 7)
OriGene ORF clones in mouse, rat for FSTL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FSTL3 (NM_005860)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSTL3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSTL3
Sirion Biotech Customized lentivirus for stable overexpression of FSTL3 
                     Customized lentivirus expression plasmids for stable overexpression of FSTL3 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FSTL3
OriGene qSTAR qPCR primer pairs in human, mouse for FSTL3
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FSTL3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSTL3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSTL3

Additional mRNA sequence: 

AK291958.1 AK311521.1 AK311566.1 AK313341.1 AL050194.1 AY358917.1 BC005839.2 

15 DOTS entries:

DT.214397  DT.95113751  DT.100877144  DT.100837077  DT.100766103  DT.100831673  DT.100877145  DT.92026480 
DT.121451243  DT.40196195  DT.100806374  DT.100877139  DT.95113755  DT.100768822  DT.91919235 

24/341 AceView cDNA sequences (see all 341):

BM693076 BM695180 CB133106 CN482782 BM666358 BX366673 CR605640 BI761253 
BM691558 CD251804 BX338959 CR611991 BQ935689 CR616021 AI085978 AY358917 
CR591319 CB961969 CR622567 CR609759 BQ887301 BU543286 CR608155 BU730201 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FSTL3 (see all 6)    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
SP1:              -           -     -     -     -                                 
SP2:                                      -     -                                 
SP3:                                                                              
SP4:                                            -                                 
SP5:                          -     -     -     -                                 


ECgene alternative splicing isoforms for FSTL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FSTL3 expression in normal human tissues (normalized intensities)      FSTL3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTGACATCC
FSTL3 Expression
About this image


FSTL3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/7 selected tissues (see all 7) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Human Retinal Pigment Epithelial Cells (HRPEpiC)   
         optic nerve head astrocytes   
 
 Placenta (Extraembryonic Tissues)
         placenta   
 
 Endothelium (Cardiovascular System)
         aorta   
 
 Adrenal Gland (Endocrine System)
         adrenal cortex   
 
 Bone (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced SK11 cells

See FSTL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FSTL3

SOURCE GeneReport for Unigene cluster: Hs.529038

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
Tissue specificity: Expressed in a wide range of tissues

    SABiosciences Custom PCR Arrays for FSTL3
Primer
Products:
OriGene qPCR primer pairs and template standards for FSTL3
OriGene qSTAR qPCR primer pairs in human, mouse for FSTL3
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FSTL3
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSTL3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSTL3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FSTL3 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fstl31 , 5 follistatin-like 31, 5 83.33(n)1
84.52(a)1
  10 (39.72 cM)5
835541  NM_031380.21  NP_113557.11 
 797772725 
chicken
(Gallus gallus)
Aves FSTL31 follistatin-like 3 (secreted glycoprotein) 69.28(n)
64.46(a)
  770427  XM_001233760.2  XP_001233761.2 
zebrafish
(Danio rerio)
Actinopterygii fstl31 follistatin-like 3 (secreted glycoprotein) 60.91(n)
60.45(a)
  557352  NM_001030111.2  NP_001025282.2 
fruit fly
(Drosophila melanogaster)
Insecta Fs6
Follistatin
11(a)
1 → many
2R(11111061-11129084)


ENSEMBL Gene Tree for FSTL3 (if available)
TreeFam Gene Tree for FSTL3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FSTL3 gene
FST2  
5 SIMAP similar genes for FSTL3 using alignment to 3 protein entries:     FSTL3_HUMAN (see all proteins):
FST    SPINK4    AGRN    tmp_locus_3    WUGSC

FSTL3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/243 SNPs in FSTL3 are shown (see all 243)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs81008701,2
C,F,H--674443(+) GCCACG/AGCGGG 1 -- us2k19Minor allele frequency- A:0.08NS EA NA WA 1204
rs1896672071,2
C--674509(+) ACAGGA/GTCCCA 1 -- us2k10--------
rs37610161,2
C,F--674566(+) GAGGCC/TAAGGC 1 -- us2k15Minor allele frequency- T:0.25NA WA EA 362
rs739181751,2
C,F--674588(+) GGCGGG/AGTGTC 1 -- us2k14Minor allele frequency- A:0.19WA CSA 124
rs1916653081,2
--674693(+) ACGGCA/GGGGTG 1 -- us2k10--------
rs1119794581,2
F--674724(+) AGGGTT/CCCGTC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
rs1888915011,2
--674761(+) ATTCCC/TGGGGG 1 -- us2k10--------
rs1427142351,2
C--674800(+) ACGGC-/GGGGTGTC 1 -- us2k10--------
rs1815929341,2
--674811(+) TCCCCC/GCTCAG 1 -- us2k10--------
rs3760117281,2
C--674823(+) GAGAAC/TCAGGG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FSTL3 (676389 - 683392 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/18 variations for FSTL3 (see all 18):    About this table     
Variant IDTypeSubtypePubMed ID
esv2717766CNV Deletion23290073
nsv470101CNV Loss18288195
dgv3526n71CNV Loss21882294
dgv3528n71CNV Loss21882294
dgv3515n71CNV Loss21882294
dgv3541n71CNV Loss21882294
nsv910109CNV Loss21882294
nsv910260CNV Loss21882294
dgv3516n71CNV Loss21882294
dgv3531n71CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FSTL3
DNA2.0 Custom Variant and Variant Library Synthesis for FSTL3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605343    OMIM disorders: --

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
  • Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia.
    Translocation t(11;19)(q13;p13) with CCDN1

  • 19 diseases for FSTL3:    About MalaCards
    blood disorders    ovarian endometriosis    chronic leukemia    gestational diabetes
    endometrial adenocarcinoma    endometriosis    pre-eclampsia    b-cell chronic lymphocytic leukemia
    eclampsia    down syndrome    hypoxia    diabetes mellitus
    rheumatoid arthritis    chronic lymphocytic leukemia    adenocarcinoma    arthritis
    hepatocellular carcinoma    leukemia    neuronitis


    FSTL3 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for FSTL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia b-cell 65 2 15451575 (1), 12493714 (1)
    lymphocytic leukemia chronic b-cell 51.9 1 17395406 (1)
    hyperplasia 10.7 1 17229845 (1)
    tumors 0 4 17671190 (2), 19740438 (1), 17395406 (1)

    Genatlas disease: FSTL3
    B cell chronic leukemia with a translocation t(11;19)(p13;q13) juxtaposing CCND1 and FSTL3 with an expression of
    the FSTL3 in hematopoietic cells


    Export disorders for FSTL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FSTL3 gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with FSTL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. (PubMed id 9671416)1, 2, 3, 9 Hayette S.... Rimokh R. (1998)
    2. Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. (PubMed id 16150905)1, 2, 9 Saito S.... Schneyer A. (2005)
    3. Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells. (PubMed id 12970321)1, 2, 9 Wang H.Q....Noda Y. (2003)
    4. AF10-dependent transcription is enhanced by its interaction with FLRG. (PubMed id 17868029)1, 2, 9 Forissier S....Rimokh R. (2007)
    5. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. (PubMed id 11948405)1, 2, 9 Bartholin L.... Rimokh R. (2002)
    6. A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin. (PubMed id 16336961)1, 2, 9 Maguer-Satta V....Rimokh R. (2006)
    7. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). (PubMed id 12697670)1, 2, 9 Schneyer A....Sidis Y. (2003)
    8. FLRG, member of the follistatin family, a new player in hematopoiesis. (PubMed id 15451575)1, 2, 9 Maguer-Satta V. and Rimokh R. (2004)
    9. The structure of FSTL3.activin A complex. Differential binding of N- terminal domains influences follistatin-type antagonist specificity. (PubMed id 18768470)1, 2, 9 Stamler R....Thompson T.B. (2008)
    10. Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. (PubMed id 22052913)1, 2 Cash J.N.... Thompson T.B. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10272 HGNC: 3973 AceView: FSTL3 Ensembl:ENSG00000070404 euGenes: HUgn10272
    ECgene: FSTL3 H-InvDB: FSTL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FSTL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FSTL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FSTL3 gene:
    Search GeneIP for patents involving FSTL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FSTL3 (Follistatin-related Gene Protein/FLRG)   Browse Cell Culture Products  
     ELISAs for FSTL3 (Follistatin-related Gene Protein/FLRG)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for FSTL3 (Follistatin-related Gene Protein/FLRG)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FSTL3  
     OriGene qPCR primer pairs and template standards for FSTL3   OriGene Protein Over-expression Lysate for FSTL3  
     OriGene MassSpec something-or-other for FSTL3   OriGene clones in human, mouse for FSTL3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FSTL3   OriGene Purified Protein for FSTL3  
     OriGene ORF clones in mouse, rat for FSTL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FSTL3   OriGene Custom Protein Services for FSTL3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FSTL3
     QIAGEN SeqTarget long-range PCR primers for resequencing FSTL3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSTL3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSTL3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSTL3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSTL3
     GenScript Custom Purified and Recombinant Proteins Services for FSTL3 GenScript cDNA clones with any tag delivered in your preferred vector for FSTL3
     GenScript Custom Assay Services for FSTL3 GenScript Custom Superior Antibodies Services for FSTL3
     GenScript Custom overexpressing Cell Line Services for FSTL3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FSTL3 promoter
     Search Chromatin IP Primers for FSTL3
     RT2 qPCR Primer Assay in human, mouse, rat FSTL3
     GNC Network for FSTL3
     SABiosciences Custom PCR Arrays for FSTL3
     Search Tocris compounds for FSTL3
     Proteins and Antibodies for FSTL3
     Cell Lysates for FSTL3
     cDNA Clones for FSTL3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FSTL3 antibodies
     FSTL3 proteins
     FSTL3 lysates
     Antibodies for FSTL3
     See all of Abcam's Antibodies, Kits and Proteins for FSTL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FSTL3
     Antibodies for FSTL3
     ELISAs for FSTL3
     CLIAs for FSTL3
     Search LifeMap BioReagents cell lines for FSTL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL3
     SwitchGear 3'UTR luciferase reporter plasmids for FSTL3
     SwitchGear Promoter luciferase reporter plasmids for FSTL3
     Search ThermoFisher Antibodies for FSTL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSTL3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FSTL3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FSTL3
    Customized:
     lentivirus for stable overexpression of FSTL3
     lentivirus expression plasmids for stable overexpression of FSTL3
     adenovirus for overexpression of FSTL3
     LSBio Antibodies in human, mouse, rat for FSTL3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FSTL3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4