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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FSTL3 Gene

protein-coding   GIFtS: 59
GCID: GC19P000676

follistatin-like 3 (secreted glycoprotein)

 Explore 20 diseases affiliated with
FSTL3 via our new
 Human Malady Compendium 
Biological research products
for FSTL3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Follistatin-Like 3 (Secreted Glycoprotein)1 2
FLRG1 2 3 5
FSRP1 2
Follistatin-Like Protein 32 3
Follistatin-Related Gene Protein2 3
Follistatin-Related Protein 32

External Ids:    HGNC: 39731   Entrez Gene: 102722   Ensembl: ENSG000000704047   OMIM: 6053435   UniProtKB: O956333   

Export aliases for FSTL3 gene to outside databases

Previous GC identifers: GC19P000728 GC19P000616 GC19P000627 GC19P000446


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FSTL3:
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in
leukemogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
Function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such
us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective
on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in
hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to
fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma.
Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10

Gene Wiki entry for FSTL3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FSTL3 gene promoter:
         Max1   Lmo2   MyoD   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FSTL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FSTL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSTL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

FSTL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSTL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000676:  view genomic region     (about GC identifiers)

Start:
676,389 bp from pter      End:
683,392 bp from pter
Size:
7,004 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633 (See protein sequence)
Recommended Name: Follistatin-related protein 3 precursor  
Size: 263 amino acids; 27663 Da
Subunit: Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10;
the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN
Subcellular location: Isoform 1: Secreted
Subcellular location: Isoform 2: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in
different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27
according to (PubMed:16150905)
3 PDB 3D structures from and Proteopedia for FSTL3:
2KCX (3D)        3B4V (3D)        3SEK (3D)    
Secondary accessions: A8K7E3
Alternative initiation: 2 isoforms:  O95633-1   O95633-2   

Explore the universe of human proteins at neXtProt for FSTL3: NX_O95633

FSTL3 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_005851.1  
ENSEMBL proteins: 
 ENSP00000166139   ENSP00000468558   ENSP00000466383   ENSP00000466449  
Reactome Protein details: O95633
Human Recombinant Protein Products: 
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Novus Biologicals FSTL3 Lysate
Sino Biological Recombinant Protein for FSTL3
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Uscn Proteins for FSTL3

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IDA16150905
GO:0005634nucleus IDA16150905
GO:0005794Golgi apparatus IEA--
GO:0030141secretory granule IEA--
GO:0044306neuron projection terminus IEA--


FSTL3 for ontologies           About GeneDecksing



FSTL3 Antibody Products: 
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Uscn ELISAs and CLIAs for FSTL3


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FSTL3 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR017878 TB_dom
 IPR002350 Prot_inh_Kazal
 IPR015369 Follistatin/Osteonectin_EGF
 IPR003645 Fol_N
 IPR011497 Kazal-type_dom

Graphical View of Domain Structure for InterPro Entry O95633

ProtoNet protein and cluster: O95633

1 Blocks protein family: IPB011497 Protease inhibitor

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
Similarity: Contains 2 follistatin-like domains
Similarity: Contains 2 Kazal-like domains
Similarity: Contains 1 TB (TGF-beta binding) domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
Function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such
us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective
on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in
hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to
fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma.
Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10

     Genatlas biochemistry entry for FSTL3:
follistatin-like 3,secreted glycoprotein,expressed in a wide range of adult tissues,not detected in hematopoietic cells
except in patients with a B cell chronic leukemia and a translocation t(11;19)(q13;p13)

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidFSTL3 3' UTR sequence
Inhib. RNA
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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001968fibronectin binding IPI16336961
GO:0005515protein binding IPI15574124
GO:0048185activin binding IPI12697670


FSTL3 for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for FSTL3:
 Increased gamma-H2AX phosphory  Low eccentricity cells 

Animal Models:
     Mouse knock-outs for FSTL3: Fstl3tm1Lex Fstl3tm1Alsc Fstl3tm1.1Sjl
     7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fstl3):
 adipose tissue  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 
 muscle  no phenotypic analysis 

FSTL3 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signal transduction Activin A signaling regulation
Signal transduction Activin A signaling regulation1.00
Signal transduction_Activin A signaling regulation0.96
2Signaling by NODAL
Signaling by Activin0.36
Antagonism of Activin by Follistatin0.00
3Signaling by GPCR
Signal Transduction0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FSTL3
    Signal transduction Activin A signaling regulation


1 GeneGo (Thomson Reuters) Pathway for FSTL3
    Signal transduction Activin A signaling regulation

3        Reactome Pathways for FSTL3
    Signaling by Activin
Signal Transduction
Antagonism of Activin by Follistatin



FSTL3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FSTL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for FSTL3 (O956331, 3 ENSP000001661394) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
ADAM12O43184-21, ENSP000003576684EBI-2625790,EBI-2625865 I2D: score=1 STRING: ENSP00000357668
FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
MSTNO147933, ENSP000002609504I2D: score=2 STRING: ENSP00000260950
INHBAP084763, ENSP000002422084I2D: score=1 STRING: ENSP00000242208
SMAD4Q134853, ENSP000003415514I2D: score=2 STRING: ENSP00000341551
About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001503ossification IEA--
GO:0001822kidney development IEA--
GO:0002244hematopoietic progenitor cell differentiation IDA15451575
GO:0006351transcription, DNA-dependent IEA--
GO:0006357regulation of transcription from RNA polymerase II promoter IDA11948405


FSTL3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FSTL3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FSTL3
2 Novoseek chemical compound relationships for FSTL3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone 7.1 2 12970321 (1)
heparin 0 7 15471966 (4), 11956142 (1)

Search CenterWatch for drugs/clinical trials and news about FSTL3 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FSTL3 gene: 
NM_005860.2  

Unigene Cluster for FSTL3:

Follistatin-like 3 (secreted glycoprotein)
Hs.529038  [show with all ESTs]
Unigene Representative Sequence: NM_005860
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000166139(uc002lpk.1 uc010drt.1) ENST00000591552 ENST00000588773
ENST00000589185 ENST00000592058 ENST00000592947 ENST00000591573

miRNA
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5 QIAGEN miScript miRNA Assays for microRNAs that regulate FSTL3:
hsa-miR-4316 hsa-miR-124 hsa-miR-506 hsa-miR-1827 hsa-miR-1910
SwitchGear 3'UTR luciferase reporter plasmidFSTL3 3' UTR sequence
Inhib. RNA
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Clone
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSTL3

Additional cDNA sequence: 

AK291958.1 AK311521.1 AK311566.1 AK313341.1 AL050194.1 AY358917.1 BC005839.2 

15 DOTS entries:

DT.214397  DT.95113751  DT.100877144  DT.100837077  DT.100766103  DT.100831673  DT.100877145  DT.92026480 
DT.121451243  DT.40196195  DT.100806374  DT.100877139  DT.95113755  DT.100768822  DT.91919235 

24/341 AceView cDNA sequences (see all 341):

CN482782 BU730201 CR605640 BM666358 CR616021 BQ935689 CB133106 AY358917 
CR611991 BX338959 BM695180 BI761253 CD251804 BM693076 BX366673 BU687696 
CB961969 CR591319 AI085978 BM691558 CR608155 AA258582 BQ887301 BP376158 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FSTL3 (see all 6)    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
SP1:              -           -     -     -     -                                 
SP2:                                      -     -                                 
SP3:                                                                              
SP4:                                            -                                 
SP5:                          -     -     -     -                                 


ECgene alternative splicing isoforms for FSTL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FSTL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGACATCC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

FSTL3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Cardiomyocyte-like cells (Spontaneous differen...)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See FSTL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FSTL3

SOURCE GeneReport for Unigene cluster: Hs.529038

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
Tissue specificity: Expressed in a wide range of tissues

    SABiosciences Custom PCR Arrays for FSTL3
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSTL3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FSTL3 gene from 3/16 species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves FSTL31 follistatin-like 3 (secreted glycoprotein) 69.28(n)
64.46(a)
  770427  XM_001233760.2  XP_001233761.2 
zebrafish
(Danio rerio)
Actinopterygii fstl31 follistatin-like 3 (secreted glycoprotein) 60.91(n)
60.45(a)
  557352  NM_001030111.2  NP_001025282.2 
fruit fly
(Drosophila melanogaster)
Insecta Fs6
Follistatin
11(a)
1 → many
2R(11111061-11129084)


ENSEMBL Gene Tree for FSTL3 (if available)
TreeFam Gene Tree for FSTL3 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FSTL3 gene
FST2  
5 SIMAP similar genes for FSTL3 using alignment to 4 protein entries:     FSTL3_HUMAN (see all proteins):
FST    AGRN    SPINK4    tmp_locus_3    WUGSC

FSTL3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/194 NCBI SNPs in FSTL3 are shown (see all 194    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs81008701,2
C,F,H,--674443(+) GCCACG/AGCGGG 1 -- us2k19Minor allele frequency- A:0.08NS EA NA WA 1204
rs1896672071,2
--674509(+) ACAGGA/GTCCCA 1 -- us2k10--------
rs37610161,2
C,--674566(+) GAGGCC/TAAGGC 1 -- us2k15Minor allele frequency- T:0.25NA WA EA 362
rs739181751,2
C,F,--674588(+) GGCGGG/AGTGTC 1 -- us2k14Minor allele frequency- A:0.19WA CSA 124
rs1916653081,2
--674693(+) ACGGCA/GGGGTG 1 -- us2k10--------
rs1119794581,2
--674724(+) AGGGTT/CCCGTC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
rs1888915011,2
--674761(+) ATTCCC/TGGGGG 1 -- us2k10--------
rs1427142351,2
C,--674800(+) ACGGC-/GGGGTGTC 1 -- us2k10--------
rs1815929341,2
--674811(+) TCCCCC/GCTCAG 1 -- us2k10--------
rs1857227111,2
--674954(+) TGGCCA/GCTGGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FSTL3 (676389 - 683392 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FSTL3
     2 CNVs: 30052 30050

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FSTL3 for disorders           About GeneDecksing

OMIM gene information: 605343    OMIM disorders: --

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
  • Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia.
  • Translocation t(11;19)(q13;p13) with CCDN1

    20 diseases for FSTL3:    About MalaCards
    pre-eclampsia    muscle hypertrophy    blood disorders    gestational diabetes
    ovarian endometriosis    eclampsia    diabetes mellitus    endometrial adenocarcinoma
    rheumatoid arthritis    endometriosis    down syndrome    leukemia
    hematopoiesis    hepatocellular carcinoma    arthritis    adenocarcinoma
    hypoxia    carcinoma    neuronitis    chronic leukemia

    4 Novoseek disease relationships for FSTL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia b-cell 65 2 15451575 (1), 12493714 (1)
    lymphocytic leukemia chronic b-cell 51.9 1 17395406 (1)
    hyperplasia 10.7 1 17229845 (1)
    tumors 0 4 17671190 (2), 19740438 (1), 17395406 (1)

    Genatlas disease: FSTL3
    B cell chronic leukemia with a translocation t(11;19)(p13;q13) juxtaposing CCND1 and FSTL3 with an expression of the
    FSTL3 in hematopoietic cells


    Export disorders for FSTL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FSTL3 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with FSTL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. (PubMed id 9671416)1, 2, 3, 9 Hayette S.... Rimokh R. (1998)
    2. Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. (PubMed id 16150905)1, 2, 9 Saito S.... Schneyer A. (2005)
    3. Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells. (PubMed id 12970321)1, 2, 9 Wang H.Q....Noda Y. (2003)
    4. AF10-dependent transcription is enhanced by its interaction with FLRG. (PubMed id 17868029)1, 2, 9 Forissier S....Rimokh R. (2007)
    5. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. (PubMed id 11948405)1, 2, 9 Bartholin L.... Rimokh R. (2002)
    6. A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin. (PubMed id 16336961)1, 2, 9 Maguer-Satta V....Rimokh R. (2006)
    7. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). (PubMed id 12697670)1, 2, 9 Schneyer A....Sidis Y. (2003)
    8. FLRG, member of the follistatin family, a new player in hematopoiesis. (PubMed id 15451575)1, 2, 9 Maguer-Satta V. and Rimokh R. (2004)
    9. The structure of FSTL3.activin A complex. Differential binding of N- terminal domains influences follistatin-type antagonist specificity. (PubMed id 18768470)1, 2, 9 Stamler R....Thompson T.B. (2008)
    10. Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. (PubMed id 22052913)1, 2 Cash J.N.... Thompson T.B. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10272 HGNC: 3973 AceView: FSTL3 Ensembl:ENSG00000070404 euGenes: HUgn10272
    ECgene: FSTL3 H-InvDB: FSTL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FSTL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FSTL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FSTL3 gene:
    Search GeneIP for patents involving FSTL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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