Aliases for FSTL3 Gene
External Ids for FSTL3 Gene
Previous GeneCards Identifiers for FSTL3 Gene
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for FSTL3 Gene
FSTL3 (Follistatin Like 3) is a Protein Coding gene. Diseases associated with FSTL3 include Chronic Leukemia and Chronic Lymphocytic Leukemia. Among its related pathways are Signaling by NODAL and DNA Damage/Telomere Stress Induced Senescence. GO annotations related to this gene include fibronectin binding and activin binding. An important paralog of this gene is FST.
UniProtKB/Swiss-Prot for FSTL3 Gene
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.