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Aliases for FSTL3 Gene

Aliases for FSTL3 Gene

  • Follistatin-Like 3 (Secreted Glycoprotein) 2 3
  • FLRG 3 4 6
  • Follistatin-Related Gene Protein 3 4
  • Follistatin-Like Protein 3 3 4
  • Follistatin-Related Protein 3 3
  • Follistatin-Related Protein 2
  • FSRP 3

External Ids for FSTL3 Gene

Previous GeneCards Identifiers for FSTL3 Gene

  • GC19P000728
  • GC19P000616
  • GC19P000627
  • GC19P000446

Summaries for FSTL3 Gene

Entrez Gene Summary for FSTL3 Gene

  • Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FSTL3 Gene

FSTL3 (Follistatin-Like 3 (Secreted Glycoprotein)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include fibronectin binding and activin binding. An important paralog of this gene is FST.

UniProtKB/Swiss-Prot for FSTL3 Gene

  • Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Gene Wiki entry for FSTL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL3 Gene

Genomics for FSTL3 Gene

Regulatory Elements for FSTL3 Gene

Genomic Location for FSTL3 Gene

Start:
676,365 bp from pter
End:
683,392 bp from pter
Size:
7,028 bases
Orientation:
Plus strand

Genomic View for FSTL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FSTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL3 Gene

Proteins for FSTL3 Gene

  • Protein details for FSTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95633-FSTL3_HUMAN
    Recommended name:
    Follistatin-related protein 3
    Protein Accession:
    O95633
    Secondary Accessions:
    • A8K7E3

    Protein attributes for FSTL3 Gene

    Size:
    263 amino acids
    Molecular mass:
    27663 Da
    Quaternary structure:
    • Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN.

    Three dimensional structures from OCA and Proteopedia for FSTL3 Gene

    Alternative splice isoforms for FSTL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSTL3 Gene

Proteomics data for FSTL3 Gene at MOPED

Post-translational modifications for FSTL3 Gene

  • Glycosylation at Asn73 and Asn215
  • Modification sites at PhosphoSitePlus

Other Protein References for FSTL3 Gene

Antibody Products

  • R&D Systems Antibodies for FSTL3 (Follistatin-related Gene Protein/FLRG)

No data available for DME Specific Peptides for FSTL3 Gene

Domains for FSTL3 Gene

Protein Domains for FSTL3 Gene

Suggested Antigen Peptide Sequences for FSTL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95633

UniProtKB/Swiss-Prot:

FSTL3_HUMAN :
  • O95633
Domain:
  • Contains 2 follistatin-like domains.
  • Contains 2 Kazal-like domains.
  • Contains 1 TB (TGF-beta binding) domain.
genes like me logo Genes that share domains with FSTL3: view

No data available for Gene Families for FSTL3 Gene

Function for FSTL3 Gene

Molecular function for FSTL3 Gene

GENATLAS Biochemistry: follistatin-like 3,secreted glycoprotein,expressed in a wide range of adult tissues,not detected in hematopoietic cells except in patients with a B cell chronic leukemia and a translocation t(11;19)(q13;p13)
UniProtKB/Swiss-Prot Function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Gene Ontology (GO) - Molecular Function for FSTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 16336961
GO:0005515 protein binding IPI 15574124
GO:0048185 activin binding IPI 12697670
genes like me logo Genes that share ontologies with FSTL3: view
genes like me logo Genes that share phenotypes with FSTL3: view

Animal Models for FSTL3 Gene

MGI Knock Outs for FSTL3:

Animal Model Products

CRISPR Products

miRNA for FSTL3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FSTL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FSTL3 Gene

Localization for FSTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL3 Gene

Isoform 1: Secreted.
Isoform 2: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. {ECO:0000269 PubMed:16150905}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSTL3 Gene COMPARTMENTS Subcellular localization image for FSTL3 gene
Compartment Confidence
extracellular 5
nucleus 5
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FSTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16150905
GO:0005634 nucleus IDA 16150905
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with FSTL3: view

Pathways for FSTL3 Gene

genes like me logo Genes that share pathways with FSTL3: view

Pathways by source for FSTL3 Gene

1 Sino Biological pathway for FSTL3 Gene
1 GeneGo (Thomson Reuters) pathway for FSTL3 Gene

Gene Ontology (GO) - Biological Process for FSTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001822 kidney development IEA --
GO:0002244 hematopoietic progenitor cell differentiation IDA 15451575
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 11948405
genes like me logo Genes that share ontologies with FSTL3: view

Compounds for FSTL3 Gene

(2) Novoseek inferred chemical compound relationships for FSTL3 Gene

Compound -log(P) Hits PubMed IDs
progesterone 7.1 1
heparin 0 5
genes like me logo Genes that share compounds with FSTL3: view

Transcripts for FSTL3 Gene

Unigene Clusters for FSTL3 Gene

Follistatin-like 3 (secreted glycoprotein):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FSTL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - -
SP6:

Relevant External Links for FSTL3 Gene

GeneLoc Exon Structure for
FSTL3
ECgene alternative splicing isoforms for
FSTL3

Expression for FSTL3 Gene

mRNA expression in normal human tissues for FSTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FSTL3 Gene

SOURCE GeneReport for Unigene cluster for FSTL3 Gene Hs.529038

mRNA Expression by UniProt/SwissProt for FSTL3 Gene

O95633-FSTL3_HUMAN
Tissue specificity: Expressed in a wide range of tissues.
genes like me logo Genes that share expressions with FSTL3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FSTL3 Gene

Orthologs for FSTL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSTL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSTL3 35
  • 99.24 (n)
  • 98.85 (a)
FSTL3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FSTL3 35
  • 88.63 (n)
  • 90.8 (a)
FSTL3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FSTL3 35
  • 91.8 (n)
  • 91.13 (a)
FSTL3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fstl3 35
  • 83.27 (n)
  • 84.71 (a)
Fstl3 16
Fstl3 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FSTL3 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSTL3 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fstl3 35
  • 83.4 (n)
  • 84.71 (a)
chicken
(Gallus gallus)
Aves FSTL3 35
  • 69.8 (n)
  • 64.49 (a)
FSTL3 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fstl3 35
  • 61.36 (n)
  • 65.93 (a)
zebrafish
(Danio rerio)
Actinopterygii fstl3 35
  • 60.94 (n)
  • 60.18 (a)
fstl3 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fs 36
  • 12 (a)
OneToMany
Species with no ortholog for FSTL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSTL3 Gene

ENSEMBL:
Gene Tree for FSTL3 (if available)
TreeFam:
Gene Tree for FSTL3 (if available)

Paralogs for FSTL3 Gene

Paralogs for FSTL3 Gene

Selected SIMAP similar genes for FSTL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FSTL3: view

Variants for FSTL3 Gene

Sequence variations from dbSNP and Humsavar for FSTL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs13730 -- 682,010(+) CTTCC(G/T)CTCCT utr-variant-3-prime
rs15490 -- 683,249(+) CTCCA(G/T)CCTCC utr-variant-3-prime
rs736615 -- 679,363(+) AGTGC(C/G)GCACT intron-variant
rs1046245 -- 683,209(+) CCGGT(C/T)TGGGG utr-variant-3-prime
rs1046253 -- 683,221(+) GAGGA(A/G)TGTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FSTL3 Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3515n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3526n71 CNV Loss 21882294
dgv3528n71 CNV Loss 21882294
dgv3531n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
dgv3537n71 CNV Loss 21882294
dgv3540n71 CNV Loss 21882294
dgv3541n71 CNV Loss 21882294
nsv910260 CNV Loss 21882294
esv2717766 CNV Deletion 23290073

Relevant External Links for FSTL3 Gene

HapMap Linkage Disequilibrium report
FSTL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL3 Gene

Disorders for FSTL3 Gene

UniProtKB/Swiss-Prot

FSTL3_HUMAN
  • Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.

(4) Novoseek inferred disease relationships for FSTL3 Gene

Disease -log(P) Hits PubMed IDs
leukemia b-cell 65 2
lymphocytic leukemia chronic b-cell 51.9 1
hyperplasia 10.7 1
tumors 0 4

Genatlas disease for FSTL3 Gene

B cell chronic leukemia with a translocation t(11;19)(p13;q13) juxtaposing CCND1 and FSTL3 with an expression of the FSTL3 in hematopoietic cells
genes like me logo Genes that share disorders with FSTL3: view

Publications for FSTL3 Gene

  1. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. (PMID: 9671416) Hayette S. … Rimokh R. (Oncogene 1998) 2 3 4 23
  2. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. (PMID: 11948405) Bartholin L. … Rimokh R. (Oncogene 2002) 3 4 23
  3. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). (PMID: 12697670) Schneyer A. … Sidis Y. (Endocrinology 2003) 3 4 23
  4. Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells. (PMID: 12970321) Wang H.Q. … Noda Y. (J. Clin. Endocrinol. Metab. 2003) 3 4 23
  5. FLRG, member of the follistatin family, a new player in hematopoiesis. (PMID: 15451575) Maguer-Satta V. … Rimokh R. (Mol. Cell. Endocrinol. 2004) 3 4 23

Products for FSTL3 Gene

Sources for FSTL3 Gene

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