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FSTL3 Gene

protein-coding   GIFtS: 60
GCID: GC19P000676

Follistatin-Like 3 (Secreted Glycoprotein)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Follistatin-Like 3 (Secreted Glycoprotein)1 2     Follistatin-Related Protein1
FLRG2 3 5     FSRP2
Follistatin-Like Protein 32 3     Follistatin-Related Protein 32
Follistatin-Related Gene Protein2 3     

External Ids:    HGNC: 39731   Entrez Gene: 102722   Ensembl: ENSG000000704047   OMIM: 6053435   UniProtKB: O956333   

Export aliases for FSTL3 gene to outside databases

Previous GC identifers: GC19P000728 GC19P000616 GC19P000627 GC19P000446


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FSTL3 Gene:
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in
leukemogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FSTL3 Gene:
FSTL3 (follistatin-like 3 (secreted glycoprotein)) is a protein-coding gene. GO annotations related to this gene include activin binding and fibronectin binding. An important paralog of this gene is FST.

UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
Function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family,
such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more
effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc.
Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic
cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone
marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction
with MLLT10

Gene Wiki entry for FSTL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the FSTL3 gene promoter:
         Max1   Lmo2   MyoD   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FSTL3 promoter sequence
   Search Chromatin IP Primers for FSTL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FSTL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

FSTL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSTL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000676:  view genomic region     (about GC identifiers)

Start:
676,389 bp from pter      End:
683,392 bp from pter
Size:
7,004 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633 (See protein sequence)
Recommended Name: Follistatin-related protein 3 precursor  
Size: 263 amino acids; 27663 Da
Subunit: Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with
MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with
MSTN
3 PDB 3D structures from and Proteopedia for FSTL3:
2KCX (3D)        3B4V (3D)        3SEK (3D)    
Secondary accessions: A8K7E3
Alternative initiation: 2 isoforms:  O95633-1   O95633-2   

Explore the universe of human proteins at neXtProt for FSTL3: NX_O95633

Explore proteomics data for FSTL3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn73, Asn215

  • See FSTL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005851.1  
    ENSEMBL proteins: 
     ENSP00000166139   ENSP00000468558   ENSP00000466383  
    Reactome Protein details: O95633

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017878 TB_dom
     IPR002350 Kazal_dom
     IPR015369 Follistatin/Osteonectin_EGF
     IPR003645 Fol_N

    Graphical View of Domain Structure for InterPro Entry O95633

    ProtoNet protein and cluster: O95633

    1 Blocks protein domain: IPB011497 Protease inhibitor

    UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
    Similarity: Contains 2 follistatin-like domains
    Similarity: Contains 2 Kazal-like domains
    Similarity: Contains 1 TB (TGF-beta binding) domain


    Find genes that share domains with FSTL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSTL3_HUMAN, O95633
    Function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family,
    such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more
    effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc.
    Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic
    cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone
    marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction
    with MLLT10

         Genatlas biochemistry entry for FSTL3:
    follistatin-like 3,secreted glycoprotein,expressed in a wide range of adult tissues,not detected in hematopoietic
    cells except in patients with a B cell chronic leukemia and a translocation t(11;19)(q13;p13)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IPI16336961
    GO:0005515protein binding IPI15574124
    GO:0048185activin binding IPI12697670
         
    Find genes that share ontologies with FSTL3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FSTL3:
     Increased gamma-H2AX phosphory  Low eccentricity cells 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fstl3):
     adipose tissue  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 
     muscle  no phenotypic analysis 

    Find genes that share phenotypes with FSTL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FSTL3: Fstl3tm1Lex Fstl3tm1Alsc Fstl3tm1.1Sjl

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    Block miRNA regulation of human, mouse, rat FSTL3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate FSTL3:
    hsa-miR-4316 hsa-miR-124 hsa-miR-506 hsa-miR-1827 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidFSTL3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FSTL3_HUMAN, O95633: Isoform 1: Secreted
    FSTL3_HUMAN, O95633: Isoform 2: Nucleus. Note=Although alternative initiation has been demonstrated and resulted
    in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at
    Met-27 according to (PubMed:16150905)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    golgi apparatus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA16150905
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IEA--

    Find genes that share ontologies with FSTL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FSTL3 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by NODAL
    Signaling by Activin0.39
    Antagonism of Activin by Follistatin0.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Packaging Of Telomere Ends
    Signal transduction Activin A signaling regulation0.40
    4TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway


    Find genes that share SuperPaths with FSTL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FSTL3
        Signal transduction Activin A signaling regulation

    1 Sino Biological Pathway for FSTL3
        TGF-beta Signaling Pathway

    1 Reactome Pathway for FSTL3
        Antagonism of Activin by Follistatin


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FSTL3
    Interactions:

        GeneGlobe Interaction Network for FSTL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for FSTL3 (O956331, 3 ENSP000001661394) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAM12O43184-21, ENSP000003576684EBI-2625790,EBI-2625865 I2D: score=1 STRING: ENSP00000357668
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    MSTNO147933, ENSP000002609504I2D: score=2 STRING: ENSP00000260950
    INHBAP084763, ENSP000002422084I2D: score=1 STRING: ENSP00000242208
    SMAD4Q134853, ENSP000003415514I2D: score=2 STRING: ENSP00000341551
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001822kidney development IEA--
    GO:0002244hematopoietic progenitor cell differentiation IDA15451575
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA11948405

    Find genes that share ontologies with FSTL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FSTL3

    2 Novoseek inferred chemical compound relationships for FSTL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 7.1 2 12970321 (1)
    heparin 0 7 15471966 (4), 11956142 (1)



    Find genes that share compounds with FSTL3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FSTL3 gene: 
    NM_005860.2  

    Unigene Cluster for FSTL3:

    Follistatin-like 3 (secreted glycoprotein)
    Hs.529038  [show with all ESTs]
    Unigene Representative Sequence: NM_005860
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000166139(uc002lpk.1 uc010drt.1) ENST00000606071 ENST00000591552
    ENST00000588773 ENST00000589185 ENST00000592058 ENST00000592947 ENST00000591573
    ENST00000605925
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    Additional mRNA sequence: 

    AK291958.1 AK311521.1 AK311566.1 AK313341.1 AL050194.1 AY358917.1 BC005839.2 

    15 DOTS entries:

    DT.214397  DT.95113751  DT.100877144  DT.100837077  DT.100766103  DT.100831673  DT.100877145  DT.92026480 
    DT.121451243  DT.40196195  DT.100806374  DT.100877139  DT.95113755  DT.100768822  DT.91919235 

    Selected AceView cDNA sequences (see all 341):

    CR605640 CB133106 BX366673 BU543286 BM666358 CD251804 BU730201 BI761253 
    CR608155 BM691558 BM693076 BM695180 BQ935689 BP376158 CR622567 AA258582 
    AI085978 BQ887301 CR611991 CN482782 BX338959 CR591319 CR609759 CR616021 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FSTL3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:              -           -     -     -     -                                 
    SP2:                                      -     -                                 
    SP3:                                                                              
    SP4:                                            -                                 
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for FSTL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FSTL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGACATCC
    FSTL3 Expression
    About this image


    FSTL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SK11 cells
    FSTL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FSTL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529038

    UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
    Tissue specificity: Expressed in a wide range of tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FSTL3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fstl31 , 5 follistatin-like 31, 5 83.27(n)1
    84.71(a)1
      10 (39.72 cM)5
    835541  NM_031380.21  NP_113557.11 
     797772725 
    chicken
    (Gallus gallus)
    Aves FSTL31 follistatin-like 3 (secreted glycoprotein) 69.8(n)
    64.49(a)
      770427  XM_001233760.3  XP_001233761.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fstl31 follistatin-like 3 (secreted glycoprotein) 61.36(n)
    65.93(a)
      548587  NM_001015870.1  NP_001015870.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fstl31 follistatin-like 3 (secreted glycoprotein) 60.94(n)
    60.18(a)
      557352  NM_001030111.2  NP_001025282.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fs6
    Follistatin
    12(a)
    1 → many
    2R(11111061-11129084)


    ENSEMBL Gene Tree for FSTL3 (if available)
    TreeFam Gene Tree for FSTL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FSTL3 gene
    FST2  
    5 SIMAP similar genes for FSTL3 using alignment to 3 protein entries:     FSTL3_HUMAN (see all proteins):
    FST    SPINK4    AGRN    tmp_locus_3    WUGSC

    Find genes that share paralogs with FSTL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FSTL3 (see all 243)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81008701,2
    C,F,H--674443(+) GCCACG/AGCGGG 1 -- us2k19Minor allele frequency- A:0.08NS EA NA WA 1204
    rs1896672071,2
    C--674509(+) ACAGGA/GTCCCA 1 -- us2k10--------
    rs37610161,2
    C,F--674566(+) GAGGCC/TAAGGC 1 -- us2k15Minor allele frequency- T:0.25NA WA EA 362
    rs739181751,2
    C,F--674588(+) GGCGGG/AGTGTC 1 -- us2k14Minor allele frequency- A:0.19WA CSA 124
    rs1916653081,2
    --674693(+) ACGGCA/GGGGTG 1 -- us2k10--------
    rs1119794581,2
    F--674724(+) AGGGTT/CCCGTC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1888915011,2
    --674761(+) ATTCCC/TGGGGG 1 -- us2k10--------
    rs1427142351,2
    C--674800(+) ACGGC-/GGGGTGTC 1 -- us2k10--------
    rs1815929341,2
    --674811(+) TCCCCC/GCTCAG 1 -- us2k10--------
    rs3760117281,2
    C--674823(+) GAGAAC/TCAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FSTL3 (676389 - 683392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FSTL3 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717766CNV Deletion23290073
    nsv470101CNV Loss18288195
    dgv3526n71CNV Loss21882294
    dgv3528n71CNV Loss21882294
    dgv3515n71CNV Loss21882294
    dgv3541n71CNV Loss21882294
    nsv910109CNV Loss21882294
    nsv910260CNV Loss21882294
    dgv3516n71CNV Loss21882294
    dgv3531n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FSTL3
    DNA2.0 Custom Variant and Variant Library Synthesis for FSTL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605343    OMIM disorders: --

    UniProtKB/Swiss-Prot: FSTL3_HUMAN, O95633
  • Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia.
    Translocation t(11;19)(q13;p13) with CCDN1


  • Find genes that share disorders with FSTL3           About GenesLikeMe

    4 Novoseek inferred disease relationships for FSTL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia b-cell 65 2 15451575 (1), 12493714 (1)
    lymphocytic leukemia chronic b-cell 51.9 1 17395406 (1)
    hyperplasia 10.7 1 17229845 (1)
    tumors 0 4 17671190 (2), 19740438 (1), 17395406 (1)

    Genatlas disease: FSTL3
    B cell chronic leukemia with a translocation t(11;19)(p13;q13) juxtaposing CCND1 and FSTL3 with an expression of
    the FSTL3 in hematopoietic cells


    Export disorders for FSTL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FSTL3 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with FSTL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. (PubMed id 9671416)1, 2, 3, 9 Hayette S.... Rimokh R. (Oncogene 1998)
    2. Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. (PubMed id 16150905)1, 2, 9 Saito S.... Schneyer A. (Endocrinology 2005)
    3. Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells. (PubMed id 12970321)1, 2, 9 Wang H.Q.... Noda Y. (J. Clin. Endocrinol. Metab. 2003)
    4. AF10-dependent transcription is enhanced by its interaction with FLRG. (PubMed id 17868029)1, 2, 9 Forissier S....Rimokh R. (Biol. Cell 2007)
    5. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. (PubMed id 11948405)1, 2, 9 Bartholin L.... Rimokh R. (Oncogene 2002)
    6. A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin. (PubMed id 16336961)1, 2, 9 Maguer-Satta V.... Rimokh R. (Exp. Cell Res. 2006)
    7. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). (PubMed id 12697670)1, 2, 9 Schneyer A.... Sidis Y. (Endocrinology 2003)
    8. FLRG, member of the follistatin family, a new player in hematopoiesis. (PubMed id 15451575)1, 2, 9 Maguer-Satta V. and Rimokh R. (Mol. Cell. Endocrinol. 2004)
    9. The structure of FSTL3.activin A complex. Differential binding of N- terminal domains influences follistatin-type antagonist specificity. (PubMed id 18768470)1, 2, 9 Stamler R....Thompson T.B. (J. Biol. Chem. 2008)
    10. Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. (PubMed id 22052913)1, 2 Cash J.N.... Thompson T.B. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10272 HGNC: 3973 AceView: FSTL3 Ensembl:ENSG00000070404 euGenes: HUgn10272
    ECgene: FSTL3 H-InvDB: FSTL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FSTL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FSTL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FSTL3 gene:
    Search GeneIP for patents involving FSTL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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