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Aliases for FSTL1 Gene

Aliases for FSTL1 Gene

  • Follistatin-Like 1 2 3
  • FRP 3 4 6
  • Follistatin-Like Protein 1 3 4
  • MIR198 3 6
  • Follistatin-Related Protein 1 3
  • FSL1 3

External Ids for FSTL1 Gene

Previous GeneCards Identifiers for FSTL1 Gene

  • GC03M116747
  • GC03M119753
  • GC03M121394
  • GC03M121434
  • GC03M121595
  • GC03M120111

Summaries for FSTL1 Gene

Entrez Gene Summary for FSTL1 Gene

  • This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FSTL1 Gene

FSTL1 (Follistatin-Like 1) is a Protein Coding gene. Diseases associated with FSTL1 include rheumatoid arthritis. Among its related pathways are Signaling by GPCR and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is FSTL4.

UniProtKB/Swiss-Prot for FSTL1 Gene

  • May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).

Gene Wiki entry for FSTL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL1 Gene

Genomics for FSTL1 Gene

Regulatory Elements for FSTL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FSTL1 Gene

120,392,293 bp from pter
120,451,253 bp from pter
58,961 bases
Minus strand

Genomic View for FSTL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FSTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL1 Gene

Proteins for FSTL1 Gene

  • Protein details for FSTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Follistatin-related protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K523
    • B4DTT5
    • D3DN90
    • Q549Z0

    Protein attributes for FSTL1 Gene

    308 amino acids
    Molecular mass:
    34986 Da
    Quaternary structure:
    • Interacts with SCN10A

    Alternative splice isoforms for FSTL1 Gene


neXtProt entry for FSTL1 Gene

Proteomics data for FSTL1 Gene at MOPED

Post-translational modifications for FSTL1 Gene

  • Glycosylation at Asn144, Asn175, and Asn180
  • Modification sites at PhosphoSitePlus

Other Protein References for FSTL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FSTL1 (Follistatin-like 1/FSTL1)

No data available for DME Specific Peptides for FSTL1 Gene

Domains for FSTL1 Gene

Gene Families for FSTL1 Gene

  • EFHAND :EF-hand domain containing

Graphical View of Domain Structure for InterPro Entry



  • Q12841
  • Contains 2 EF-hand domains.
  • Contains 1 follistatin-like domain.
  • Contains 1 Kazal-like domain.
  • Contains 1 VWFC domain.
genes like me logo Genes that share domains with FSTL1: view

Function for FSTL1 Gene

Molecular function for FSTL1 Gene

UniProtKB/Swiss-Prot Function:
May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).

Gene Ontology (GO) - Molecular Function for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 19060904
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FSTL1: view
genes like me logo Genes that share phenotypes with FSTL1: view

Animal Models for FSTL1 Gene

MGI Knock Outs for FSTL1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FSTL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FSTL1 Gene

Localization for FSTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL1 Gene


Subcellular locations from

Jensen Localization Image for FSTL1 Gene COMPARTMENTS Subcellular localization image for FSTL1 gene
Compartment Confidence
extracellular 4
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with FSTL1: view

Pathways for FSTL1 Gene

genes like me logo Genes that share pathways with FSTL1: view

Pathways by source for FSTL1 Gene

1 Sino Biological pathway for FSTL1 Gene
2 Reactome pathways for FSTL1 Gene

Gene Ontology (GO) - Biological Process for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030509 BMP signaling pathway TAS --
GO:0042594 response to starvation IEA --
genes like me logo Genes that share ontologies with FSTL1: view

Transcripts for FSTL1 Gene

Unigene Clusters for FSTL1 Gene

Follistatin-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FSTL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP6: - - -
SP8: - - - -

Relevant External Links for FSTL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSTL1 Gene

mRNA expression in normal human tissues for FSTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FSTL1 Gene

This gene is overexpressed in Amniocyte (46.7) and Liver (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FSTL1 Gene

SOURCE GeneReport for Unigene cluster for FSTL1 Gene Hs.269512

mRNA Expression by UniProt/SwissProt for FSTL1 Gene

Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis.
genes like me logo Genes that share expressions with FSTL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for FSTL1 Gene

Orthologs for FSTL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSTL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FSTL1 35
  • 93.46 (n)
  • 97.71 (a)
FSTL1 36
  • 97 (a)
(Canis familiaris)
Mammalia FSTL1 35
  • 92.96 (n)
  • 97.54 (a)
FSTL1 36
  • 93 (a)
(Mus musculus)
Mammalia Fstl1 35
  • 88.89 (n)
  • 91.83 (a)
Fstl1 16
Fstl1 36
  • 92 (a)
(Pan troglodytes)
Mammalia FSTL1 35
  • 99.46 (n)
  • 99.68 (a)
ptr-mir-198 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fstl1 35
  • 88.45 (n)
  • 92.81 (a)
(Monodelphis domestica)
Mammalia FSTL1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia FSTL1 36
  • 71 (a)
(Gallus gallus)
Aves FSTL1 35
  • 82.87 (n)
  • 90 (a)
FSTL1 36
  • 84 (a)
(Anolis carolinensis)
Reptilia FSTL1 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fstl1 35
  • 74.23 (n)
  • 75.89 (a)
Str.10997 35
African clawed frog
(Xenopus laevis)
Amphibia xFRP 35
(Danio rerio)
Actinopterygii fstl1b 35
  • 72.09 (n)
  • 74.74 (a)
FSTL1 (3 of 3) 36
  • 5 (a)
fstl1a 36
  • 65 (a)
fstl1b 36
  • 70 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
Species with no ortholog for FSTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSTL1 Gene

Gene Tree for FSTL1 (if available)
Gene Tree for FSTL1 (if available)

Paralogs for FSTL1 Gene

Paralogs for FSTL1 Gene

Selected SIMAP similar genes for FSTL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FSTL1: view

Variants for FSTL1 Gene

Sequence variations from dbSNP and Humsavar for FSTL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2488 -- 120,394,439(-) TTTAA(A/G)TAGTC utr-variant-3-prime
rs8865 -- 120,395,115(-) TTTAG(A/C)ATTTC utr-variant-3-prime
rs14909 -- 120,394,466(+) AAAGA(C/G)ATTCA utr-variant-3-prime
rs869246 -- 120,408,618(-) CCCAG(C/G)CATCT intron-variant
rs869247 -- 120,408,389(-) TTTAC(A/G)TAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSTL1 Gene

Variant ID Type Subtype PubMed ID
nsv877376 CNV Gain 21882294
nsv829698 CNV Gain 17160897
nsv3969 CNV Insertion 18451855
nsv436396 CNV Deletion 17901297
esv2669703 CNV Deletion 23128226
esv25295 CNV Loss 19812545

Relevant External Links for FSTL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL1 Gene

Disorders for FSTL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FSTL1 Gene in MalaCards »

(1) Diseases for FSTL1 Gene including...

(1) Novoseek inferred disease relationships for FSTL1 Gene

Disease -log(P) Hits PubMed IDs
rheumatoid arthritis 28.3 3

Relevant External Links for FSTL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FSTL1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for FSTL1 Gene

Publications for FSTL1 Gene

  1. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. (PMID: 7957230) Zwijsen A. … Slegers H. (Eur. J. Biochem. 1994) 2 3 4 23
  2. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. (PMID: 9786430) Tanaka M. … Nakao K. (Int. Immunol. 1998) 2 3 4 23
  3. Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. (PMID: 15638044) Ehara Y. … Tokunaga K. (Clin. Exp. Rheumatol. 2004) 3 4 23 48
  4. Expression of follistatin-related genes is altered in heart failure. (PMID: 18617621) Lara-Pezzi E. … Barton P.J. (Endocrinology 2008) 3 23
  5. Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis. (PMID: 18796737) Chan Q.K. … Cheung A.N. (Carcinogenesis 2009) 3 23

Products for FSTL1 Gene

Sources for FSTL1 Gene

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