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Set Analyses:

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FSTL1 Gene

protein-coding GIFtS: 64
GCID: GC03M120111

Follistatin-Like 1

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Follistatin-Like 1¹ ²
FRP² ³ ⁵
Follistatin-Like Protein 1² ³
MIR198² ⁵
FSL1²
Follistatin-Related Protein 1²

External Ids:	HGNC: 3972¹	Entrez Gene: 11167²	Ensembl: ENSG00000163430⁷	OMIM: 605547⁵	UniProtKB: Q12841³

Export aliases for FSTL1 gene to outside databases

Previous GC identifers: GC03M116747 GC03M119753 GC03M121394 GC03M121434 GC03M121595

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FSTL1 Gene:

This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module,

a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an

autoantigen associated with rheumatoid arthritis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FSTL1 Gene:

FSTL1 (follistatin-like 1) is a protein-coding gene. Diseases associated with FSTL1 include cluttering, and rheumatoid arthritis. GO annotations related to this gene include heparin binding and calcium ion binding. An important paralog of this gene is FSTL5.

UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841

Function: May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin

(By similarity)

Gene Wiki entry for FSTL1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000003.12 NC_018914.2 NT_005612.17

Regulatory elements:

Regulatory transcription factor binding sites in the FSTL1 gene promoter:
c-Fos AP-1 ATF-2 POU2F1 POU2F1a POU2F1b ARP-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FSTL1 promoter sequence

Search Chromatin IP Primers for FSTL1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FSTL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q13.33

FSTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSTL1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M120111: view genomic region (about GC identifiers)

Start:	120,111,140 bp from pter	End:	120,170,100 bp from pter
Size:	58,961 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841 (See protein sequence)

Recommended Name: Follistatin-related protein 1 precursor

Size: 308 amino acids; 34986 Da

Subunit: Interacts with SCN10A

Secondary accessions: D3DN90 Q549Z0

Explore the universe of human proteins at neXtProt for FSTL1: NX_Q12841

Explore proteomics data for FSTL1 at MOPED

Post-translational modifications:

Glycosylation² at Asn144, Asn175, Asn180

Modification sites at PhosphoSitePlus

See FSTL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_009016.1

ENSEMBL proteins:

ENSP00000295633 ENSP00000418389 ENSP00000394355 ENSP00000418505

Reactome Protein details: Q12841

FSTL1 Human Recombinant Protein Products:

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	Novus Biologicals FSTL1 Proteins Novus Biologicals FSTL1 Lysate
	Sino Biological Recombinant Protein for FSTL1 Sino Biological Cell Lysate for FSTL1
	ProSpec Recombinant Protein for FSTL1
	Cloud-Clone Corp. Proteins for FSTL1

FSTL1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals FSTL1 Antibodies
	Abcam antibodies for FSTL1
	Cloud-Clone Corp. Antibodies for FSTL1
	ThermoFisher Antibody for FSTL1
	LSBio Antibodies in human, mouse, rat for FSTL1

FSTL1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	R&D Systems ELISAs for FSTL1 (Follistatin-like 1/FSTL1)
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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for FSTL1 Cloud-Clone Corp. CLIAs for FSTL1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

EFHAND: EF-hand domain containing

5 InterPro protein domains:

IPR002350 Kazal_dom

IPR011992 EF-hand-dom_pair

IPR002048 EF_hand_dom

IPR015369 Follistatin/Osteonectin_EGF

IPR003645 Fol_N

Graphical View of Domain Structure for InterPro Entry Q12841

ProtoNet protein and cluster: Q12841

4 Blocks protein domains:

IPB001007 von Willebrand factor

IPB001239 Kazal-type serine protease inhibitor signature

IPB003645 Follistatin-like

IPB011497 Protease inhibitor

UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 follistatin-like domain

Similarity: Contains 1 Kazal-like domain

Similarity: Contains 1 VWFC domain

FSTL1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: FSTL1_HUMAN, Q12841

Function: May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin

(By similarity)

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008201	heparin binding	IEA	--

FSTL1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for FSTL1:

Low eccentricity cells

12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Fstl1):

behavior/neurological	cardiovascular system	embryogenesis	homeostasis/metabolism	integument
limbs/digits/tail	mortality/aging	muscle	nervous system	renal/urinary system
respiratory system	skeleton

FSTL1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for FSTL1: Fstl1^tm1.2Mvdh Fstl1^tm1.1Ning Fstl1^tm1.1Nju

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FSTL1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FSTL1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FSTL1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FSTL1

miRNA Products:		miRTarBase miRNAs that target FSTL1: hsa-mir-124-3p (MIRT022846), hsa-mir-149-5p (MIRT045682), hsa-mir-155-5p (MIRT020891), hsa-mir-26b-5p (MIRT029771), hsa-let-7b-5p (MIRT051922), hsa-mir-206 (MIRT001789), hsa-mir-615-3p (MIRT040347)

		Block miRNA regulation of human, mouse, rat FSTL1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate FSTL1 (see all 42):
		hsa-miR-429 hsa-miR-24-1* hsa-miR-29a hsa-miR-25 hsa-miR-766 hsa-miR-890 hsa-miR-124 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: FSTL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for FSTL1
		Predesigned siRNA for gene silencing in human, mouse, rat FSTL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FSTL1

Clone Products:		OriGene clones in human, mouse for FSTL1 (see all 6) OriGene ORF clones in mouse, rat for FSTL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FSTL1 (NM_007085)
		Sino Biological Human cDNA Clone for FSTL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSTL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSTL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FSTL1
		Browse ESI BIO Cell Lines and PureStem Progenitors for FSTL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

FSTL1_HUMAN, Q12841: Secreted (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	4
cytosol	1
golgi apparatus	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	TAS	9786430

FSTL1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FSTL1 About

See pathways by source

SuperPath

Contained pathways About

Signaling by GPCR

Signal Transduction

0.58

Signaling by BMP

Signaling by BMP

0.35

TGF-beta Signaling Pathway (sino)

TGF-beta Signaling Pathway

Pathways by source See SuperPaths
Show all pathways

1 Sino Biological Pathway for FSTL1

TGF-beta Signaling Pathway

1 Reactome Pathway for FSTL1

Signaling by BMP

FSTL1 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for FSTL1
Interactions:

Search GeneGlobe Interaction Network for FSTL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

Selected Interacting proteins for FSTL1 (Q12841^{1, 2, 3} ENSP00000295633⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DIP2A	Q14689¹^,²^,³, ENSP00000392066⁴	EBI-2349801,EBI-2564275 MINT-7990639 MINT-7990744 MINT-7990758 MINT-7991032 I2D: score=1 STRING: ENSP00000392066
TGFB1	P01137¹^,²^,³, ENSP00000221930⁴	EBI-2349801,EBI-779636 MINT-7990941 MINT-7990813 I2D: score=1 STRING: ENSP00000221930
ACVR2B	Q13705²^,³, ENSP00000340361⁴	MINT-7990852 I2D: score=1 STRING: ENSP00000340361
BMP4	P12644²^,³, ENSP00000245451⁴	MINT-7990874 I2D: score=1 STRING: ENSP00000245451
FST	P19883²^,³, ENSP00000256759⁴	MINT-7990781 I2D: score=1 STRING: ENSP00000256759

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030509	BMP signaling pathway	TAS	--

FSTL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for FSTL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FSTL1 gene:

NM_007085.4

Unigene Cluster for FSTL1:

Follistatin-like 1

Hs.269512 [show with all ESTs]

Unigene Representative Sequence: NM_007085

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295633(uc003eds.3 uc011bjh.2) ENST00000480823 ENST00000424703

ENST00000488318 ENST00000468098 ENST00000469005 ENST00000464690(uc010hrb.2)

ENST00000472536 ENST00000485968 ENST00000467994

miRNA Products:		Block miRNA regulation of human, mouse, rat FSTL1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate FSTL1 (see all 42):
		hsa-miR-429 hsa-miR-24-1* hsa-miR-29a hsa-miR-25 hsa-miR-766 hsa-miR-890 hsa-miR-124 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: FSTL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for FSTL1
		Predesigned siRNA for gene silencing in human, mouse, rat FSTL1

Clone Products:		OriGene clones in human, mouse for FSTL1 (see all 6) OriGene ORF clones in mouse, rat for FSTL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FSTL1 (NM_007085)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSTL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSTL1

Primer Products:		OriGene qPCR primer pairs and template standards for FSTL1 OriGene qSTAR qPCR primer pairs in human, mouse for FSTL1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat FSTL1
		QuantiTect SYBR Green Assays in human, mouse, rat FSTL1
		QuantiFast Probe-based Assays in human, mouse, rat FSTL1

Additional mRNA sequence:

AF288537.1 AK025860.1 AK289388.1 AK291138.1 AK300356.1 AK300436.1 AK311050.1 AK312261.1

AL050228.1 BC000055.2 BC017413.1 BX647421.1 U06863.1

Selected DOTS entries (see all 36):

DT.95241071 DT.85105021 DT.97856274 DT.99975686 DT.100756493 DT.100890370 DT.92072253 DT.100890385

DT.100717292 DT.100800011 DT.120908865 DT.100890382 DT.120908767 DT.120908805 DT.102838967 DT.100890373

DT.100890380 DT.120908787 DT.120908788 DT.92072220 DT.95241174 DT.100039299 DT.100736192 DT.100890375

Selected AceView cDNA sequences (see all 838):

BM771174 CN485110 CN482871 R81103 BM721082 T30501 BQ007658 CA397300

BP345697 BQ008951 AU131134 CD675804 AW196984 BU517310 N67716 AI202985

BP353287 BP343842 AA044900 BV177507 AW615366 BQ012143 BU677677 BM698311

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for FSTL1 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	·	16c
SP1:									-		-		-		-		-								-																-
SP2:									-						-		-
SP3:									-		-		-		-		-								-
SP4:									-		-		-		-
SP5:

ECgene alternative splicing isoforms for FSTL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FSTL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCGTGACTCT

About this image

FSTL1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 17) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Epithalamus

Lung (Respiratory System)
Basal Cells Trachea

Neural Tube (Nervous System)
Metencephalon

Blood (Hematopoietic System)
Hematopoietic Stem Cells Hematopoietic Bone Marrow

Limb (Muscoskeletal System)
Autopod

FSTL1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

FSTL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.269512

UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841

Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis

Custom PCR Arrays for FSTL1

Primer Products:		OriGene qPCR primer pairs and template standards for FSTL1 OriGene qSTAR qPCR primer pairs in human, mouse for FSTL1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat FSTL1
		QuantiTect SYBR Green Assays in human, mouse, rat FSTL1
		QuantiFast Probe-based Assays in human, mouse, rat FSTL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FSTL1 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fstl1^{1 , 5}	follistatin-like 1^{1, 5}	88.89(n)¹ 91.83(a)¹		16 (26.48 cM)⁵ 14314¹ NM_008047.5¹ NP_032073.2¹ 37776873⁵
chicken (Gallus gallus)	Aves	FSTL1¹	follistatin-like 1	82.87(n) 90(a)		395349 XM_004938169.1 XP_004938226.1
lizard (Anolis carolinensis)	Reptilia	FSTL1⁶	follistatin-like 1	80(a)	1 ↔ 1	GL343326.1(140189-189500)
African clawed frog (Xenopus laevis)	Amphibia	xFRP²	follistatin-related protein	78.58(n)		BC043983.1
zebrafish (Danio rerio)	Actinopterygii	fstl1b¹	follistatin-like 1b	72.09(n) 74.74(a)		324309 NM_001039621.1 NP_001034710.1

ENSEMBL Gene Tree for FSTL1 (if available)
TreeFam Gene Tree for FSTL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for FSTL1 gene

FSTL5² FSTL4²

6 SIMAP similar genes for FSTL1 using alignment to 4 protein entries: FSTL1_HUMAN (see all proteins):

DKFZp566D234 FSTL4 AGRN tmp_locus_3 SPINK6 WUGSC

FSTL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58296615^1,2	C,F	--	120112728(+)	`AGGTGC/TATTCT`	1	--	ds500¹		3		WA	122
rs182642885^1,2		--	120112760(+)	`AAGCCA/GTCATC`	1	--	ds500¹		0	--	--	--	--
rs187065580^1,2		--	120112856(+)	`CAGTCC/TGAGGC`	1	--	ds500¹		0	--	--	--	--
rs189989506^1,2		--	120112972(+)	`GTCCCC/GGAGTA`	1	--	ds500¹		0	--	--	--	--
rs182901953^1,2		--	120113005(+)	`CCCAGA/GAGAAA`	1	--	ds500¹		0	--	--	--	--
rs1147694^1,2	C,F,A,H	--	120113124(-)	`GTGATG/AGTTTT`	1	--	ut3¹		11		NA WA CSA	256
rs2488^1,2	C,F,A,H	--	120113286(-)	`TTTAAG/ATAGTC`	1	--	ut3¹ ese³		24		NS EA NA WA CSA	903
rs1057231^1,2	C,F,A,H	--	120113403(-)	`GAAACA/CTTCCC`	1	--	ut3¹		18		EA NA WA CSA	2071
rs150137558^1,2		--	120113416(+)	`TGGACA/GCTGGA`	1	--	ut3¹		0	--	--	--	--
rs145529707^1,2		--	120113436(+)	`ATGCTA/TTAGTG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FSTL1 (120111140 - 120170100 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for FSTL1: About this table

Variant ID	Type	Subtype	PubMed ID
esv2669703	CNV	Deletion	23128226
nsv436396	CNV	Deletion	17901297
nsv3969	CNV	Insertion	18451855
esv25295	CNV	Loss	19812545
nsv877376	CNV	Gain	21882294
nsv829698	CNV	Gain	17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605547 OMIM disorders: --

14 diseases for FSTL1:
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cluttering rheumatoid arthritis arthritis endometrial adenocarcinoma

rheumatic disease osteoarthritis schizophrenia adenocarcinoma

obesity lung cancer prostate cancer prostatitis

endotheliitis cerebritis

FSTL1 for disorders About GeneDecksing

1 Novoseek inferred disease relationship for FSTL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatoid arthritis	28.3	3	15638044 (2), 12502727 (1)

Genetic Association Database (GAD): FSTL1
Human Genome Epidemiology (HuGE) Navigator: FSTL1 (3 documents)

Export disorders for FSTL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FSTL1 gene, integrated from 10 sources (see all 40):
(articles sorted by number of sources associating them with FSTL1)

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Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. (PubMed id 15638044)^{1, 2, 4, 9} Ehara Y....Tokunaga K. (Clin. Exp. Rheumatol. 2004)
Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. (PubMed id 9786430)^{1, 2, 3, 9} Tanaka M.... Nakao K. (Int. Immunol. 1998)
Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. (PubMed id 7957230)^{1, 2, 3, 9} Zwijsen A.... Slegers H. (Eur. J. Biochem. 1994)
Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)^{1, 4} Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PubMed id 20347265)^{1, 4} Xu Y....Liu P. (Schizophr. Res. 2010)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (J. Proteome Res. 2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (Protein Sci. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis. (PubMed id 18796737)^{1, 9} Chan Q.K....Cheung A.N. (Carcinogenesis 2009)
Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma. (PubMed id 19109154)^{1, 9} Clutter S.D....Hirsch R. (J. Immunol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11167	HGNC: 3972	AceView: FSTL1	Ensembl:ENSG00000163430	euGenes: HUgn11167
ECgene: FSTL1	H-InvDB: FSTL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FSTL1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FSTL1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FSTL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FSTL1 gene:
Search GeneIP for patents involving FSTL1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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