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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FSTL1 Gene

protein-coding   GIFtS: 62
GCID: GC03M120111

Follistatin-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Follistatin-Like 11 2
FRP2 3 5
Follistatin-Like Protein 12 3
FSL12
MIR1982
Follistatin-Related Protein 12

External Ids:    HGNC: 39721   Entrez Gene: 111672   Ensembl: ENSG000001634307   OMIM: 6055475   UniProtKB: Q128413   

Export aliases for FSTL1 gene to outside databases

Previous GC identifers: GC03M116747 GC03M119753 GC03M121394 GC03M121434 GC03M121595


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FSTL1 Gene:
This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module,
a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an
autoantigen associated with rheumatoid arthritis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FSTL1 Gene: 
FSTL1 (follistatin-like 1) is a protein-coding gene. Diseases associated with FSTL1 include cluttering, and rheumatoid arthritis, and among its related super-pathways are Signaling by GPCR and BMP signalling and regulation. GO annotations related to this gene include heparin binding and calcium ion binding. An important paralog of this gene is FSTL5.

UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841
Function: May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin
(By similarity)

Gene Wiki entry for FSTL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FSTL1 gene promoter:
         c-Fos   AP-1   ATF-2   POU2F1   POU2F1a   POU2F1b   ARP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSTL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FSTL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.33

FSTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSTL1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M120111:  view genomic region     (about GC identifiers)

Start:
120,111,140 bp from pter      End:
120,170,100 bp from pter
Size:
58,961 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841 (See protein sequence)
Recommended Name: Follistatin-related protein 1 precursor  
Size: 308 amino acids; 34986 Da
Subunit: Interacts with SCN10A
Subcellular location: Secreted (Potential)
Secondary accessions: D3DN90 Q549Z0

Explore the universe of human proteins at neXtProt for FSTL1: NX_Q12841

Explore proteomics data for FSTL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12841

  • FSTL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FSTL1 Protein Expression
    REFSEQ proteins: NP_009016.1  
    ENSEMBL proteins: 
     ENSP00000295633   ENSP00000418389   ENSP00000394355   ENSP00000418505  
    Reactome Protein details: Q12841
    Human Recombinant Protein Products for FSTL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FSTL1 (Follistatin-like 1/FSTL1)
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    Novus Biologicals FSTL1 Proteins
    Novus Biologicals FSTL1 Lysate
    Sino Biological Recombinant Protein for FSTL1
    Sino Biological Cell Lysate for FSTL1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FSTL1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9786430

    FSTL1 for ontologies           About GeneDecksing



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    Assay Products for FSTL1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR015369 Follistatin/Osteonectin_EGF
     IPR003645 Fol_N

    Graphical View of Domain Structure for InterPro Entry Q12841

    ProtoNet protein and cluster: Q12841

    4 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001239 Kazal-type serine protease inhibitor signature
    IPB003645 Follistatin-like
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 1 follistatin-like domain
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 VWFC domain


    FSTL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSTL1_HUMAN, Q12841
    Function: May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin
    (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0008201heparin binding IEA--
         
    FSTL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FSTL1:
     Low eccentricity cells 

         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fstl1):
     behavior/neurological  cardiovascular system  embryogenesis  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  renal/urinary system 
     respiratory system  skeleton 

    FSTL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FSTL1: Fstl1tm1.2Mvdh Fstl1tm1.1Ning Fstl1tm1.1Nju

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FSTL1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FSTL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FSTL1 

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate FSTL1 (see all 42):
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    SwitchGear 3'UTR luciferase reporter plasmidFSTL1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FSTL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.55
    2Signaling by BMP
    Signaling by BMP0.35
    3TGF-beta Signaling Pathway
    TGF-beta Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for FSTL1 
        TGF-beta Signaling Pathway

    2        Reactome Pathways for FSTL1
        Signal Transduction
    Signaling by BMP



    FSTL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSTL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/22 Interacting proteins for FSTL1 (Q128412, 3 ENSP000002956334) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIP2AQ146892, 3, ENSP000003920664MINT-7990639 MINT-7990744 MINT-7990758 MINT-7991032 I2D: score=1 STRING: ENSP00000392066
    TGFB1P011372, 3, ENSP000002219304MINT-7990941 MINT-7990813 I2D: score=1 STRING: ENSP00000221930
    ACVR2BQ137052, 3, ENSP000003403614MINT-7990852 I2D: score=1 STRING: ENSP00000340361
    BMP4P126442, 3, ENSP000002454514MINT-7990874 I2D: score=1 STRING: ENSP00000245451
    FSTP198832, 3, ENSP000002567594MINT-7990781 I2D: score=1 STRING: ENSP00000256759
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030509BMP signaling pathway TAS--

    FSTL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FSTL1

    Search CenterWatch for drugs/clinical trials and news about FSTL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FSTL1 gene: 
    NM_007085.4  

    Unigene Cluster for FSTL1:

    Follistatin-like 1
    Hs.269512  [show with all ESTs]
    Unigene Representative Sequence: NM_007085
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295633(uc003eds.3 uc011bjh.2) ENST00000480823 ENST00000424703
    ENST00000488318 ENST00000468098 ENST00000469005 ENST00000464690(uc010hrb.2)
    ENST00000472536 ENST00000485968 ENST00000467994
    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate FSTL1 (see all 42):
    hsa-miR-429 hsa-miR-24-1* hsa-miR-29a hsa-miR-25 hsa-miR-766 hsa-miR-890 hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidFSTL1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSTL1
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    Additional mRNA sequence: 

    AF288537.1 AK025860.1 AK289388.1 AK291138.1 AK300356.1 AK300436.1 AK311050.1 AK312261.1 
    AL050228.1 BC000055.2 BC017413.1 BX647421.1 U06863.1 

    24/36 DOTS entries (see all 36):

    DT.95241071  DT.85105021  DT.97856274  DT.99975686  DT.100756493  DT.100890370  DT.92072253  DT.100890385 
    DT.100717292  DT.100800011  DT.120908865  DT.100890382  DT.120908767  DT.120908805  DT.102838967  DT.100890373 
    DT.100890380  DT.120908787  DT.120908788  DT.92072220  DT.95241174  DT.100039299  DT.100736192  DT.100890375 

    24/838 AceView cDNA sequences (see all 838):

    BM711028 BX647421 AI690397 CN485110 AU130046 CA389480 CD172015 AI202985 
    BP344967 CD514514 AW471395 BU735938 CD518823 BM912228 BQ012148 CA448520 
    AU117873 AA044148 CD517943 BM666118 CN484435 AI283333 AW337949 AI358251 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for FSTL1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:                          -     -     -     -     -                       -                                               -                           
    SP2:                          -                 -     -                                                                                                   
    SP3:                          -     -     -     -     -                       -                                                                           
    SP4:                          -     -     -     -                                                                                                         
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for FSTL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FSTL1 expression in normal human tissues (normalized intensities)      FSTL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGTGACTCT
    FSTL1 Expression
    About this image


    FSTL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Epithalamus
     
     Heart (Cardiovascular System)
             Cardiac Myocytes   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Lung (Respiratory System)
             trachea   
     
     Limb (Muscoskeletal System)
             Autopod

    See FSTL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FSTL1

    SOURCE GeneReport for Unigene cluster: Hs.269512

    UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841
    Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FSTL1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fstl11 , 5 follistatin-like 11, 5 89.43(n)1
    92.48(a)1
      16 (26.48 cM)5
    143141  NM_008047.51  NP_032073.21 
     377768735 
    chicken
    (Gallus gallus)
    Aves FSTL11 follistatin-like 1 79.3(n)
    83.33(a)
      395349  NM_204638.1  NP_989969.1 
    lizard
    (Anolis carolinensis)
    Reptilia FSTL16
    follistatin-like 1
    80(a)
    1 ↔ 1
    GL343326.1(140189-189500)
    African clawed frog
    (Xenopus laevis)
    Amphibia xFRP2 follistatin-related protein 78.58(n)    BC043983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fstl1b1 follistatin-like 1b 71.73(n)
    73.99(a)
      324309  NM_001039621.1  NP_001034710.1 


    ENSEMBL Gene Tree for FSTL1 (if available)
    TreeFam Gene Tree for FSTL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FSTL1 gene
    FSTL52  FSTL42  
    6 SIMAP similar genes for FSTL1 using alignment to 4 protein entries:     FSTL1_HUMAN (see all proteins):
    DKFZp566D234    FSTL4    AGRN    tmp_locus_3    SPINK6    WUGSC

    FSTL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1160 SNPs in FSTL1 are shown (see all 1160)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs582966151,2
    C,F--120112728(+) AGGTGC/TATTCT 1 -- ds50013Minor allele frequency- T:0.10WA 122
    rs1826428851,2
    --120112760(+) AAGCCA/GTCATC 1 -- ds50010--------
    rs1870655801,2
    --120112856(+) CAGTCC/TGAGGC 1 -- ds50010--------
    rs1899895061,2
    --120112972(+) GTCCCC/GGAGTA 1 -- ds50010--------
    rs1829019531,2
    --120113005(+) CCCAGA/GAGAAA 1 -- ds50010--------
    rs11476941,2
    C,F,A,H--120113124(-) GTGATG/AGTTTT 1 -- ut3111Minor allele frequency- A:0.47NA WA CSA 256
    rs24881,2
    C,F,A,H--120113286(-) TTTAAG/ATAGTC 1 -- ut31 ese324Minor allele frequency- A:0.36NS EA NA WA CSA 903
    rs10572311,2
    C,F,A,H--120113403(-) GAAACA/CTTCCC 1 -- ut3118Minor allele frequency- C:0.14EA NA WA CSA 2071
    rs1501375581,2
    --120113416(+) TGGACA/GCTGGA 1 -- ut310--------
    rs1455297071,2
    --120113436(+) ATGCTA/TTAGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FSTL1 (120111140 - 120170100 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FSTL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669703CNV Deletion23128226
    nsv436396CNV Deletion17901297
    nsv3969CNV Insertion18451855
    esv25295CNV Loss19812545
    nsv877376CNV Gain21882294
    nsv829698CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605547    OMIM disorders: --

    13 diseases for FSTL1:    About MalaCards
    cluttering    rheumatoid arthritis    arthritis    endometrial adenocarcinoma
    rheumatic disease    osteoarthritis    glioblastoma    schizophrenia
    adenocarcinoma    lung cancer    prostate cancer    prostatitis
    endotheliitis


    FSTL1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FSTL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 28.3 3 15638044 (2), 12502727 (1)

    Genetic Association Database (GAD): FSTL1
    Human Genome Epidemiology (HuGE) Navigator: FSTL1 (3 documents)

    Export disorders for FSTL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FSTL1 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with FSTL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. (PubMed id 15638044)1, 2, 4, 9 Ehara Y....Tokunaga K. (2004)
    2. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. (PubMed id 9786430)1, 2, 3, 9 Tanaka M.... Nakao K. (1998)
    3. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. (PubMed id 7957230)1, 2, 3, 9 Zwijsen A.... Slegers H. (1994)
    4. Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (2010)
    5. MicroRNAs and target site screening reveals a pre-mic roRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1, 4 Xu Y....Liu P. (2010)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis. (PubMed id 18796737)1, 9 Chan Q.K....Cheung A.N. (2009)
    10. Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma. (PubMed id 19109154)1, 9 Clutter S.D....Hirsch R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11167 HGNC: 3972 AceView: FSTL1 Ensembl:ENSG00000163430 euGenes: HUgn11167
    ECgene: FSTL1 H-InvDB: FSTL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FSTL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FSTL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FSTL1 gene:
    Search GeneIP for patents involving FSTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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