Aliases for FSTL1 Gene
Aliases for FSTL1 Gene
External Ids for FSTL1 Gene
- HGNC: 3972
- Entrez Gene: 11167
- Ensembl: ENSG00000163430
- OMIM: 605547
- UniProtKB: Q12841
Previous GeneCards Identifiers for FSTL1 Gene
- GC03M116747
- GC03M119753
- GC03M121394
- GC03M121434
- GC03M121595
- GC03M120111
Summaries for FSTL1 Gene
-
This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
GeneCards Summary for FSTL1 Gene
FSTL1 (Follistatin Like 1) is a Protein Coding gene. Diseases associated with FSTL1 include Rheumatoid Arthritis and Arthritis. Among its related pathways are Signaling by GPCR and Signaling by BMP. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is FSTL4.
UniProtKB/Swiss-Prot for FSTL1 Gene
-
May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).
Additional gene information for FSTL1 Gene
- Monarch Initiative
- Search for FSTL1 at DataMed
- Search for FSTL1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL1 Gene
Genomics for FSTL1 Gene
GeneHancer (GH) Regulatory Elements for FSTL1 Gene
Promoters and enhancers for FSTL1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03I120446 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE dbSUPER | 555.2 | +1.6 | 1621 | 5.3 | KLF17 SIN3A FEZF1 ZNF335 GLIS2 POLR3A ZNF366 KLF7 EGR2 SP3 | FSTL1 RPL34P9 MIR198 | |
| GH03I119468 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 10.7 | +982.1 | 982128 | 2.2 | HDGF FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 | POGLUT1 TMEM39A RPS26P21 B4GALT4 CD80 FSTL1 TIMMDC1 ENSG00000272662 | |
| GH03I120416 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 13.3 | +31.9 | 31877 | 6.7 | PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 ZNF143 FOS ATF7 DEK | GPR156 FSTL1 LOC100130701 LRRC58 MIR198 | |
| GH03I120422 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 13 | +25.6 | 25597 | 5.5 | JUND POLR2A RCOR1 HNF4A | FSTL1 GPR156 LOC100130701 LRRC58 GSK3B ADPRH MIR198 | |
| GH03I120507 | Enhancer | 0.7 | Ensembl ENCODE | 11.6 | -56.0 | -56047 | 0.6 | CTCF ZNF680 SMC3 RAD21 NR2F2 | FSTL1 GPR156 RPL34P9 ENSG00000240774 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FSTL1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FSTL1 Gene
Genomic Locations for FSTL1 Gene
- chr3:120,392,293-120,451,253
- (GRCh38/hg38)
- Size:
- 58,961 bases
- Orientation:
- Minus strand
- chr3:120,111,140-120,170,100
- (GRCh37/hg19)
Genomic View for FSTL1 Gene
Genes around FSTL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.33 by Ensembl
- 3q13.33 by Entrez Gene
- 3q13.33 by HGNC
FSTL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FSTL1 Gene
Proteins for FSTL1 Gene
-
Protein details for FSTL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12841-FSTL1_HUMAN
- Recommended name:
- Follistatin-related protein 1
- Protein Accession:
- Q12841
- A8K523
- B4DTT5
- D3DN90
- Q549Z0
Protein attributes for FSTL1 Gene
- Size:
- 308 amino acids
- Molecular mass:
- 34986 Da
- Quaternary structure:
-
- Interacts with SCN10A.
Protein Expression for FSTL1 Gene
Post-translational modifications for FSTL1 Gene
- Glycosylation at posLast=144144, isoforms=2175, and isoforms=2180
Other Protein References for FSTL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FSTL1 (Follistatin-like 1/FSTL1)
-
Custom Antibody ServicesOriGene Antibodies for FSTL1
- Novus Biologicals Antibodies for FSTL1
-
Abcam antibodies for FSTL1
-
Cloud-Clone Corp. Antibodies for FSTL1
- Invitrogen Antibodies for FSTL1
- GeneTex FSTL1 antibody for FSTL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FSTL1
- Sino Biological Antibodies for FSTL1
Protein Products
- R&D Systems Proteins and Enzymes for FSTL1 (Follistatin-like 1/FSTL1)
- Search Origene for MassSpec and Protein Over-expression Lysates for FSTL1
- Origene Custom Protein Services for FSTL1
- Sino Biological Cell Lysates for FSTL1
- Sino Biological Recombinant Proteins for FSTL1
- ProSpec Recombinant Proteins for FSTL1
-
Cloud-Clone Corp. Proteins for FSTL1
- Search GeneTex for Proteins for FSTL1
-
ProSci Proteins for FSTL1
-
Abcam proteins for FSTL1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for FSTL1
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for FSTL1 (Follistatin-like 1/FSTL1)
-
Abcam assays for FSTL1
No data available for DME Specific Peptides for FSTL1 Gene
Domains & Families for FSTL1 Gene
Gene Families for FSTL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for FSTL1 Gene
Suggested Antigen Peptide Sequences for FSTL1 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FSTL1 Gene
Function for FSTL1 Gene
Molecular function for FSTL1 Gene
- UniProtKB/Swiss-Prot Function:
- May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).
Phenotypes From GWAS Catalog for FSTL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 19060904 |
| GO:0008201 | heparin binding | IEA,TAS | -- |
Phenotypes for FSTL1 Gene
- MGI mutant phenotypes for FSTL1:
-
inferred from 8 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- behavior/neurological phenotype
- integument phenotype
- embryo phenotype
- skeleton phenotype
- renal/urinary system phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for FSTL1:
Animal Models for FSTL1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FSTL1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for FSTL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FSTL1 gene
- Search ViGene Biosciences for FSTL1
CRISPR Products
-
OriGene CRISPR knockouts for FSTL1
- genomics-online: gRNA clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
- Applied Biological Materials CRISPR for FSTL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSTL1
- GenScript: Design CRISPR guide RNA sequences for FSTL1
miRNA for FSTL1 Gene
- miRTarBase miRNAs that target FSTL1
-
- hsa-mir-206 (MIRT001789)
- hsa-mir-155-5p (MIRT020891)
- hsa-mir-124-3p (MIRT022846)
- hsa-mir-26b-5p (MIRT029771)
- hsa-mir-615-3p (MIRT040347)
- hsa-mir-149-5p (MIRT045682)
- hsa-let-7b-5p (MIRT051922)
- hsa-mir-198 (MIRT054915)
- hsa-mir-1295b-3p (MIRT495912)
- hsa-mir-152-5p (MIRT714639)
- hsa-mir-4652-3p (MIRT714640)
- hsa-mir-4743-3p (MIRT714641)
- hsa-mir-653-3p (MIRT714642)
- hsa-mir-4420 (MIRT714643)
- hsa-mir-181b-3p (MIRT714644)
- hsa-mir-181b-2-3p (MIRT714645)
- hsa-mir-3689f (MIRT714646)
- hsa-mir-3689e (MIRT714647)
- hsa-mir-3689b-5p (MIRT714648)
- hsa-mir-3689a-5p (MIRT714649)
- hsa-mir-4679 (MIRT714650)
- hsa-mir-4677-3p (MIRT714651)
- hsa-mir-4742-3p (MIRT714652)
- hsa-mir-1208 (MIRT714653)
- hsa-mir-6760-3p (MIRT714654)
- hsa-mir-27a-3p (MIRT732311)
- hsa-mir-29a-3p (MIRT732619)
- hsa-mir-3620-3p (MIRT741737)
- hsa-mir-3918 (MIRT742930)
- hsa-mir-4524a-3p (MIRT745845)
- hsa-mir-4524b-3p (MIRT745881)
- hsa-mir-4667-3p (MIRT746790)
- hsa-mir-6750-3p (MIRT754567)
- hsa-mir-6784-3p (MIRT755771)
- hsa-mir-6862-3p (MIRT757881)
- hsa-mir-6865-3p (MIRT757919)
- hsa-mir-6895-5p (MIRT758798)
- hsa-mir-7975 (MIRT759986)
miRNA Products
- Search ViGene Biosciences for FSTL1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FSTL1
- Browse OriGene Inhibitory RNA Products For FSTL1
- genomics-online: shRNA clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FSTL1 gene
Clone Products
- Sino Biological Human cDNA Clone for FSTL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FSTL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSTL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FSTL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FSTL1
-
ViGene Biosciences adenoviral particle packaged cDNA for FSTL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FSTL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FSTL1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FSTL1 Gene
Localization for FSTL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FSTL1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| cytosol | 3 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
- Cytosol (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS,HDA | 16502470 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0070062 | extracellular exosome | IDA,HDA | 23533145 |
Pathways & Interactions for FSTL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Signaling by BMP |
.33
|
|
Pathways by source for FSTL1 Gene
2 GeneTex pathways for FSTL1 Gene
2 Reactome pathways for FSTL1 Gene
Interacting Proteins for FSTL1 Gene
Selected Interacting proteins:
Q12841-FSTL1_HUMAN
ENSP00000295633
for FSTL1 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030509 | BMP signaling pathway | TAS | -- |
| GO:0042594 | response to starvation | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0044267 | cellular protein metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for FSTL1 Gene
Drugs & Compounds for FSTL1 Gene
Transcripts for FSTL1 Gene
mRNA/cDNA for FSTL1 Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (838) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FSTL1
- genomics-online: gRNA clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
- Applied Biological Materials CRISPR for FSTL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSTL1
- GenScript: Design CRISPR guide RNA sequences for FSTL1
miRNA Products
- Search ViGene Biosciences for FSTL1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FSTL1
- Browse OriGene Inhibitory RNA Products For FSTL1
- genomics-online: shRNA clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FSTL1 gene
Clone Products
- Sino Biological Human cDNA Clone for FSTL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FSTL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSTL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FSTL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for FSTL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Neural Tube (Nervous System)
- Limb (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Larynx (Respiratory System)
-
Heart (Cardiovascular System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Amniocyte (46.7) and Liver (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FSTL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FSTL1 Gene:
FSTL1SOURCE GeneReport for Unigene cluster for FSTL1 Gene:
Hs.269512mRNA Expression by UniProt/SwissProt for FSTL1 Gene:
Q12841-FSTL1_HUMAN
Tissue specificity:
Overexpressed in synovial tissues from rheumatoid arthritis.
Evidence on tissue expression from TISSUES for FSTL1 Gene
- Nervous system(4.9)
- Kidney(4.7)
- Bone marrow(4.1)
- Heart(4.1)
- Skin(3.9)
- Lung(3.6)
- Muscle(3.6)
- Bone(3.1)
- Eye(2.9)
- Spleen(2.6)
- Thyroid gland(2.5)
- Gall bladder(2.2)
- Pancreas(2.2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for FSTL1
-
OriGene qPCR primer pairs and template standards for FSTL1
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSTL1 Gene
Orthologs for FSTL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-198 34 |
|
OneToOne | |
| FSTL1 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | FSTL1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FSTL1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fstl1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fstl1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FSTL1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FSTL1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FSTL1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FSTL1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fstl1 33 |
|
||
| Str.10997 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | xFRP 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fstl1b 33 34 |
|
||
| fstl1a 34 |
|
OneToMany | |||
| FSTL1 (3 of 3) 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for FSTL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FSTL1 Gene
(6) SIMAP similar genes for FSTL1 Gene using alignment to 4 proteins:
Variants for FSTL1 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000003817 | -- | 120,419,227(-) | G/A | intron_variant | |
| rs1000141661 | -- | 120,395,526(-) | G/T | 3_prime_UTR_variant | |
| rs1000150206 | -- | 120,424,898(-) | G/A | intron_variant | |
| rs1000200869 | -- | 120,439,604(-) | G/A | intron_variant | |
| rs1000269990 | -- | 120,404,522(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv8523n54 | CNV | loss | 21841781 |
| esv25295 | CNV | loss | 19812545 |
| esv2669703 | CNV | deletion | 23128226 |
| esv3597573 | CNV | loss | 21293372 |
| nsv1131720 | CNV | deletion | 24896259 |
| nsv3969 | CNV | insertion | 18451855 |
| nsv436396 | CNV | deletion | 17901297 |
| nsv591394 | CNV | loss | 21841781 |
| nsv829698 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.22;
24.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FSTL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FSTL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL1 Gene
Disorders for FSTL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rheumatoid arthritis |
|
|
| arthritis |
|
|
Search FSTL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FSTL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FSTL1 Gene
Publications for FSTL1 Gene
- Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. (PMID: 15638044) Ehara Y … Tokunaga K (Clinical and experimental rheumatology 2004) 3 4 22 44 58
- Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. (PMID: 9786430) Tanaka M … Nakao K (International immunology 1998) 2 3 4 22 58
- Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. (PMID: 7957230) Zwijsen A … Slegers H (European journal of biochemistry 1994) 2 3 4 22 58
- Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 44 58
- MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 44 58
Products for FSTL1 Gene
- R&D Systems Antibodies for FSTL1 (Follistatin-like 1/FSTL1)
- R&D Systems Proteins and Enzymes for FSTL1 (Follistatin-like 1/FSTL1)
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for FSTL1 (Follistatin-like 1/FSTL1)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FSTL1
- Custom Assay ServicesOriGene ELISA Kits for FSTL1
- Search Origene for MassSpec and Protein Over-expression Lysates for FSTL1
- Origene Custom Protein Services for FSTL1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FSTL1
- Browse OriGene Inhibitory RNA Products For FSTL1
- OriGene qPCR primer pairs and template standards for FSTL1
- OriGene qPCR primer pairs for FSTL1
- OriGene CRISPR knockouts for FSTL1
- OriGene ORF clones in human for FSTL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FSTL1
- GenScript: Next-day shipping of latest version cDNA ORF clones for FSTL1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FSTL1
- GenScript Custom Assay Services for FSTL1
- GenScript Custom overexpressing Cell Line Services for FSTL1
- GenScript: Design CRISPR guide RNA sequences for FSTL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FSTL1
- Sino Biological Human cDNA Clone for FSTL1
- Sino Biological Cell Lysates for FSTL1
- Sino Biological Recombinant Proteins for FSTL1
- Sino Biological Antibodies for FSTL1
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for FSTL1
- Novus Biologicals lysates and proteins for FSTL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FSTL1
- Abcam proteins for FSTL1
- Abcam assays for FSTL1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for FSTL1
- Cloud-Clone Corp. Antibodies for FSTL1
- Cloud-Clone Corp. Proteins for FSTL1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for FSTL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for FSTL1
- VectorBuilder custom plasmid, inducible vectors for FSTL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSTL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 107 available FSTL1 Antibodies ranked by validation data
- Compare Top FSTL1 Antibodies
- antibodies-online: Search results for 50 available FSTL1 Elisa Kits ranked by validation data
- Compare Top FSTL1 Elisa Kits
- antibodies-online: Search results for 27 available FSTL1 Proteins ranked by validation data
- Compare Top FSTL1 Proteins
- GeneTex FSTL1 antibody for FSTL1
- Search GeneTex for Proteins for FSTL1
- ViGene Biosciences adenoviral particle packaged cDNA for FSTL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FSTL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FSTL1 gene
- Search ViGene Biosciences for FSTL1
- Santa Cruz Biotechnology (SCBT) Antibodies for FSTL1
- Search Santa Cruz Biotechnology (SCBT) for FSTL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FSTL1
- Horizon Cell Lines for FSTL1
- genomics-online: cdna clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
- orf clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
- genomics-online: gRNA clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
- genomics-online: primer clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
- genomics-online: shRNA clones - Search results for 125 available FSTL1 gene related products
- Overview of 125 available FSTL1 gene related products
Sources for FSTL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew