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Aliases for FSTL1 Gene

Aliases for FSTL1 Gene

  • Follistatin Like 1 2 3 5
  • Follistatin-Like Protein 1 3 4
  • FRP 3 4
  • Follistatin-Related Protein 1 3
  • Follistatin-Like 1 2
  • MIR198 3
  • OCC-1 3
  • Tsc36 3
  • OCC1 3
  • FSL1 3

External Ids for FSTL1 Gene

Previous GeneCards Identifiers for FSTL1 Gene

  • GC03M116747
  • GC03M119753
  • GC03M121394
  • GC03M121434
  • GC03M121595
  • GC03M120111

Summaries for FSTL1 Gene

Entrez Gene Summary for FSTL1 Gene

  • This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FSTL1 Gene

FSTL1 (Follistatin Like 1) is a Protein Coding gene. Diseases associated with FSTL1 include Rheumatoid Arthritis and Arthritis. Among its related pathways are Signaling by GPCR and Signaling by BMP. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is FSTL4.

UniProtKB/Swiss-Prot for FSTL1 Gene

  • May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).

Gene Wiki entry for FSTL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL1 Gene

Genomics for FSTL1 Gene

Regulatory Elements for FSTL1 Gene

Enhancers for FSTL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F120416 1.3 Ensembl ENCODE 13.2 +31.9 31878 6.7 PKNOX1 ARID4B ZNF48 GATA2 ZNF143 FOS DEK NFYC MXD4 MIER2 GPR156 FSTL1 MIR198 RPL10P7 LOC100130701 LRRC58 ENSG00000242613
GH03F120422 0.8 ENCODE 12.9 +25.6 25598 5.5 CTCF PKNOX1 TAF1 SIN3A CEBPG RAD21 TEAD3 CTBP1 GATA3 FOS MIR198 FSTL1 GPR156 LOC100130701 LRRC58 GSK3B ADPRH ENSG00000242613
GH03F120506 0.8 Ensembl ENCODE 11.6 -55.7 -55748 1.2 CTCF ZNF680 SMC3 RAD21 NR2F2 FSTL1 MIR198 GPR156 RPL34P9 ENSG00000240774
GH03F120446 1.2 Ensembl ENCODE 5.2 +1.6 1621 5.3 KLF17 SIN3A FEZF1 ZNF335 GLIS2 POLR3A ZNF366 KLF7 FOS EGR2 FSTL1 RPL34P9 MIR198 ENSG00000242613
GH03F120431 1.1 Ensembl ENCODE 4.7 +15.1 15061 10.0 ELF3 HDAC1 TAF1 JUN TEAD4 ZNF175 CEBPG POLR2A ZNF239 ZNF584 ENSG00000242622 FSTL1 MIR198 ENSG00000242613
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FSTL1 on UCSC Golden Path with GeneCards custom track

Promoters for FSTL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001482793 653 2801 KLF17 SIN3A FEZF1 ZNF335 GLIS2 POLR3A ZNF366 KLF7 FOS EGR2

Genomic Location for FSTL1 Gene

Chromosome:
3
Start:
120,392,293 bp from pter
End:
120,451,253 bp from pter
Size:
58,961 bases
Orientation:
Minus strand

Genomic View for FSTL1 Gene

Genes around FSTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL1 Gene

Proteins for FSTL1 Gene

  • Protein details for FSTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12841-FSTL1_HUMAN
    Recommended name:
    Follistatin-related protein 1
    Protein Accession:
    Q12841
    Secondary Accessions:
    • A8K523
    • B4DTT5
    • D3DN90
    • Q549Z0

    Protein attributes for FSTL1 Gene

    Size:
    308 amino acids
    Molecular mass:
    34986 Da
    Quaternary structure:
    • Interacts with SCN10A.
    • Interacts with SCN10A.

    Alternative splice isoforms for FSTL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSTL1 Gene

Post-translational modifications for FSTL1 Gene

  • Glycosylation at Asn 144, Asn 175, and Asn 180
  • Modification sites at PhosphoSitePlus

Other Protein References for FSTL1 Gene

Antibody Products

  • R&D Systems Antibodies for FSTL1 (Follistatin-like 1/FSTL1)
  • Abcam antibodies for FSTL1
  • Cloud-Clone Corp. Antibodies for FSTL1
  • Santa Cruz Biotechnology (SCBT) Antibodies for FSTL1

No data available for DME Specific Peptides for FSTL1 Gene

Domains & Families for FSTL1 Gene

Gene Families for FSTL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12841

UniProtKB/Swiss-Prot:

FSTL1_HUMAN :
  • Contains 2 EF-hand domains.
Domain:
  • Contains 2 EF-hand domains.
  • Contains 1 follistatin-like domain.
  • Contains 1 Kazal-like domain.
  • Contains 1 VWFC domain.
genes like me logo Genes that share domains with FSTL1: view

Function for FSTL1 Gene

Molecular function for FSTL1 Gene

UniProtKB/Swiss-Prot Function:
May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).

Gene Ontology (GO) - Molecular Function for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 19060904
GO:0008201 heparin binding IEA,TAS --
genes like me logo Genes that share ontologies with FSTL1: view
genes like me logo Genes that share phenotypes with FSTL1: view

Animal Models for FSTL1 Gene

MGI Knock Outs for FSTL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FSTL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FSTL1 Gene

Localization for FSTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSTL1 gene
Compartment Confidence
extracellular 5
cytosol 3
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,TAS 16502470
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with FSTL1: view

Pathways & Interactions for FSTL1 Gene

SuperPathways for FSTL1 Gene

SuperPathway Contained pathways
1 Signaling by GPCR
2 Signaling by BMP
genes like me logo Genes that share pathways with FSTL1: view

Pathways by source for FSTL1 Gene

2 GeneTex pathways for FSTL1 Gene
2 Reactome pathways for FSTL1 Gene

Gene Ontology (GO) - Biological Process for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030509 BMP signaling pathway TAS --
GO:0042594 response to starvation IEA --
genes like me logo Genes that share ontologies with FSTL1: view

No data available for SIGNOR curated interactions for FSTL1 Gene

Drugs & Compounds for FSTL1 Gene

(7) Drugs for FSTL1 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anticholesteremic Agents Pharma 1983
Antimetabolites Pharma 11774
Atorvastatin Calcium Pharma HMG-CoA reductase inhibitor 743
Calcium, Dietary Pharma 5525
Hydroxymethylglutaryl-CoA Reductase Inhibitors Pharma 1956
genes like me logo Genes that share compounds with FSTL1: view

Transcripts for FSTL1 Gene

Unigene Clusters for FSTL1 Gene

Follistatin-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6: - - -
SP7:
SP8: - - - -
SP9:

Relevant External Links for FSTL1 Gene

GeneLoc Exon Structure for
FSTL1
ECgene alternative splicing isoforms for
FSTL1

Expression for FSTL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FSTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FSTL1 Gene

This gene is overexpressed in Amniocyte (46.7) and Liver (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FSTL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FSTL1 Gene:

FSTL1

SOURCE GeneReport for Unigene cluster for FSTL1 Gene:

Hs.269512

mRNA Expression by UniProt/SwissProt for FSTL1 Gene:

Q12841-FSTL1_HUMAN
Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis.
genes like me logo Genes that share expression patterns with FSTL1: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FSTL1 Gene

Orthologs for FSTL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-198 35
  • 100 (a)
OneToOne
FSTL1 34
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia FSTL1 34 35
  • 93.46 (n)
dog
(Canis familiaris)
Mammalia FSTL1 34 35
  • 92.96 (n)
mouse
(Mus musculus)
Mammalia Fstl1 34 16 35
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Fstl1 34
  • 88.45 (n)
oppossum
(Monodelphis domestica)
Mammalia FSTL1 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSTL1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves FSTL1 34 35
  • 82.87 (n)
lizard
(Anolis carolinensis)
Reptilia FSTL1 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fstl1 34
  • 74.23 (n)
Str.10997 34
African clawed frog
(Xenopus laevis)
Amphibia xFRP 34
zebrafish
(Danio rerio)
Actinopterygii fstl1b 34 35
  • 72.09 (n)
fstl1a 35
  • 65 (a)
OneToMany
FSTL1 (3 of 3) 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 7 (a)
OneToMany
Species where no ortholog for FSTL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSTL1 Gene

ENSEMBL:
Gene Tree for FSTL1 (if available)
TreeFam:
Gene Tree for FSTL1 (if available)

Paralogs for FSTL1 Gene

Paralogs for FSTL1 Gene

(6) SIMAP similar genes for FSTL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FSTL1: view

Variants for FSTL1 Gene

Sequence variations from dbSNP and Humsavar for FSTL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10560457 -- 120,412,817(+) ACATG(-/TG)CGCGC intron-variant
rs1056928 -- 120,396,067(-) TTGGC(C/T)CCCCT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1057117 -- 120,394,631(-) GCAGG(C/T)TTCCT intron-variant, utr-variant-3-prime
rs1057231 -- 120,394,556(-) GAAAC(A/C)TTCCC intron-variant, utr-variant-3-prime
rs10662375 -- 120,408,816(+) GTACC(-/TG)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSTL1 Gene

Variant ID Type Subtype PubMed ID
dgv8523n54 CNV loss 21841781
esv25295 CNV loss 19812545
esv2669703 CNV deletion 23128226
esv3597573 CNV loss 21293372
nsv1131720 CNV deletion 24896259
nsv3969 CNV insertion 18451855
nsv436396 CNV deletion 17901297
nsv591394 CNV loss 21841781
nsv829698 CNV gain 17160897

Variation tolerance for FSTL1 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSTL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL1 Gene

Disorders for FSTL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FSTL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • rheumatoid arthritis, progression of
arthritis
  • inflammatory disorder of joint
- elite association - COSMIC cancer census association via MalaCards
Search FSTL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FSTL1

Genetic Association Database (GAD)
FSTL1
Human Genome Epidemiology (HuGE) Navigator
FSTL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSTL1
genes like me logo Genes that share disorders with FSTL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FSTL1 Gene

Publications for FSTL1 Gene

  1. Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. (PMID: 15638044) Ehara Y. … Tokunaga K. (Clin. Exp. Rheumatol. 2004) 3 4 22 46 64
  2. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. (PMID: 9786430) Tanaka M. … Nakao K. (Int. Immunol. 1998) 2 3 4 22 64
  3. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. (PMID: 7957230) Zwijsen A. … Slegers H. (Eur. J. Biochem. 1994) 2 3 4 22 64
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 64
  5. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 64

Products for FSTL1 Gene

Sources for FSTL1 Gene

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