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FSTL1 Gene

protein-coding   GIFtS: 64
GCID: GC03M120111

Follistatin-Like 1

  See FSTL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Follistatin-Like 11 2
FRP2 3 5
Follistatin-Like Protein 12 3
MIR1982 5
FSL12
Follistatin-Related Protein 12

External Ids:    HGNC: 39721   Entrez Gene: 111672   Ensembl: ENSG000001634307   OMIM: 6055475   UniProtKB: Q128413   

Export aliases for FSTL1 gene to outside databases

Previous GC identifers: GC03M116747 GC03M119753 GC03M121394 GC03M121434 GC03M121595


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FSTL1 Gene:
This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module,
a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an
autoantigen associated with rheumatoid arthritis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FSTL1 Gene:
FSTL1 (follistatin-like 1) is a protein-coding gene. Diseases associated with FSTL1 include rheumatoid arthritis. GO annotations related to this gene include heparin binding and calcium ion binding. An important paralog of this gene is FSTL5.

UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841
Function: May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin
(By similarity)

Gene Wiki entry for FSTL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FSTL1 gene promoter:
         c-Fos   AP-1   ATF-2   POU2F1   POU2F1a   POU2F1b   ARP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSTL1 promoter sequence
   Search Chromatin IP Primers for FSTL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FSTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.33

FSTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSTL1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M120111:  view genomic region     (about GC identifiers)

Start:
120,111,140 bp from pter      End:
120,170,100 bp from pter
Size:
58,961 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841 (See protein sequence)
Recommended Name: Follistatin-related protein 1 precursor  
Size: 308 amino acids; 34986 Da
Subunit: Interacts with SCN10A
Secondary accessions: D3DN90 Q549Z0

Explore the universe of human proteins at neXtProt for FSTL1: NX_Q12841

Explore proteomics data for FSTL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn144, Asn175, Asn180
  • Modification sites at PhosphoSitePlus

  • See FSTL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009016.1  
    ENSEMBL proteins: 
     ENSP00000295633   ENSP00000418389   ENSP00000394355   ENSP00000418505  
    Reactome Protein details: Q12841

    FSTL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FSTL1

     
    Search eBioscience for Proteins for FSTL1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR015369 Follistatin/Osteonectin_EGF
     IPR003645 Fol_N

    Graphical View of Domain Structure for InterPro Entry Q12841

    ProtoNet protein and cluster: Q12841

    4 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001239 Kazal-type serine protease inhibitor signature
    IPB003645 Follistatin-like
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 1 follistatin-like domain
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with FSTL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSTL1_HUMAN, Q12841
    Function: May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin
    (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with FSTL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FSTL1:
     Low eccentricity cells 

         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fstl1):
     behavior/neurological  cardiovascular system  embryogenesis  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  renal/urinary system 
     respiratory system  skeleton 

    Find genes that share phenotypes with FSTL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FSTL1: Fstl1tm1.2Mvdh Fstl1tm1.1Ning Fstl1tm1.1Nju

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FSTL1
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    miRNA
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    miRTarBase miRNAs that target FSTL1:
    hsa-mir-124-3p (MIRT022846), hsa-mir-149-5p (MIRT045682), hsa-mir-155-5p (MIRT020891), hsa-mir-26b-5p (MIRT029771), hsa-let-7b-5p (MIRT051922), hsa-mir-206 (MIRT001789), hsa-mir-615-3p (MIRT040347)

    Block miRNA regulation of human, mouse, rat FSTL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FSTL1 (see all 42):
    hsa-miR-429 hsa-miR-24-1* hsa-miR-29a hsa-miR-25 hsa-miR-766 hsa-miR-890 hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidFSTL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FSTL1

    Gene Editing
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    eBioscience FlowRNA Probe Sets ( VA1-10852) for FSTL1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FSTL1_HUMAN, Q12841: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9786430

    Find genes that share ontologies with FSTL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FSTL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.58
    2Signaling by BMP
    Signaling by BMP0.35
    3TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway


    Find genes that share SuperPaths with FSTL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for FSTL1
        TGF-beta Signaling Pathway

    1 Reactome Pathway for FSTL1
        Signaling by BMP


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FSTL1
    Interactions:

        Search GeneGlobe Interaction Network for FSTL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for FSTL1 (Q128411, 2, 3 ENSP000002956334) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIP2AQ146891, 2, 3, ENSP000003920664EBI-2349801,EBI-2564275 MINT-7990639 MINT-7990744 MINT-7990758 MINT-7991032 I2D: score=1 STRING: ENSP00000392066
    TGFB1P011371, 2, 3, ENSP000002219304EBI-2349801,EBI-779636 MINT-7990941 MINT-7990813 I2D: score=1 STRING: ENSP00000221930
    ACVR2BQ137052, 3, ENSP000003403614MINT-7990852 I2D: score=1 STRING: ENSP00000340361
    BMP4P126442, 3, ENSP000002454514MINT-7990874 I2D: score=1 STRING: ENSP00000245451
    FSTP198832, 3, ENSP000002567594MINT-7990781 I2D: score=1 STRING: ENSP00000256759
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030509BMP signaling pathway TAS--

    Find genes that share ontologies with FSTL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FSTL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FSTL1 gene: 
    NM_007085.4  

    Unigene Cluster for FSTL1:

    Follistatin-like 1
    Hs.269512  [show with all ESTs]
    Unigene Representative Sequence: NM_007085
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295633(uc003eds.3 uc011bjh.2) ENST00000480823 ENST00000424703
    ENST00000488318 ENST00000468098 ENST00000469005 ENST00000464690(uc010hrb.2)
    ENST00000472536 ENST00000485968 ENST00000467994
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FSTL1 (see all 42):
    hsa-miR-429 hsa-miR-24-1* hsa-miR-29a hsa-miR-25 hsa-miR-766 hsa-miR-890 hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidFSTL1 3' UTR sequence
    Inhib. RNA
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    Flow Cytometry
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    Additional mRNA sequence: 

    AF288537.1 AK025860.1 AK289388.1 AK291138.1 AK300356.1 AK300436.1 AK311050.1 AK312261.1 
    AL050228.1 BC000055.2 BC017413.1 BX647421.1 U06863.1 

    Selected DOTS entries (see all 36):

    DT.95241071  DT.85105021  DT.97856274  DT.99975686  DT.100756493  DT.100890370  DT.92072253  DT.100890385 
    DT.100717292  DT.100800011  DT.120908865  DT.100890382  DT.120908767  DT.120908805  DT.102838967  DT.100890373 
    DT.100890380  DT.120908787  DT.120908788  DT.92072220  DT.95241174  DT.100039299  DT.100736192  DT.100890375 

    Selected AceView cDNA sequences (see all 838):

    BM771174 CN485110 CN482871 R81103 BM721082 T30501 BQ007658 CA397300 
    BP345697 BQ008951 AU131134 CD675804 AW196984 BU517310 N67716 AI202985 
    BP353287 BP343842 AA044900 BV177507 AW615366 BQ012143 BU677677 BM698311 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FSTL1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:                          -     -     -     -     -                       -                                               -                           
    SP2:                          -                 -     -                                                                                                   
    SP3:                          -     -     -     -     -                       -                                                                           
    SP4:                          -     -     -     -                                                                                                         
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for FSTL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FSTL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGTGACTCT
    FSTL1 Expression
    About this image


    FSTL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Epithalamus
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Limb (Muscoskeletal System)
             Autopod
    FSTL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FSTL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.269512

    UniProtKB/Swiss-Prot: FSTL1_HUMAN, Q12841
    Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSTL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FSTL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fstl11 , 5 follistatin-like 11, 5 88.89(n)1
    91.83(a)1
      16 (26.48 cM)5
    143141  NM_008047.51  NP_032073.21 
     377768735 
    chicken
    (Gallus gallus)
    Aves FSTL11 follistatin-like 1 82.87(n)
    90(a)
      395349  XM_004938169.1  XP_004938226.1 
    lizard
    (Anolis carolinensis)
    Reptilia FSTL16
    follistatin-like 1
    80(a)
    1 ↔ 1
    GL343326.1(140189-189500)
    African clawed frog
    (Xenopus laevis)
    Amphibia xFRP2 follistatin-related protein 78.58(n)    BC043983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fstl1b1 follistatin-like 1b 72.09(n)
    74.74(a)
      324309  NM_001039621.1  NP_001034710.1 


    ENSEMBL Gene Tree for FSTL1 (if available)
    TreeFam Gene Tree for FSTL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FSTL1 gene
    FSTL52  FSTL42  
    6 SIMAP similar genes for FSTL1 using alignment to 4 protein entries:     FSTL1_HUMAN (see all proteins):
    DKFZp566D234    FSTL4    AGRN    tmp_locus_3    SPINK6    WUGSC

    Find genes that share paralogs with FSTL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FSTL1 (see all 1160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs582966151,2
    C,F--120112728(+) AGGTGC/TATTCT 1 -- ds50013Minor allele frequency- T:0.10WA 122
    rs1826428851,2
    --120112760(+) AAGCCA/GTCATC 1 -- ds50010--------
    rs1870655801,2
    --120112856(+) CAGTCC/TGAGGC 1 -- ds50010--------
    rs1899895061,2
    --120112972(+) GTCCCC/GGAGTA 1 -- ds50010--------
    rs1829019531,2
    --120113005(+) CCCAGA/GAGAAA 1 -- ds50010--------
    rs11476941,2
    C,F,A,H--120113124(-) GTGATG/AGTTTT 1 -- ut3111Minor allele frequency- A:0.47NA WA CSA 256
    rs24881,2
    C,F,A,H--120113286(-) TTTAAG/ATAGTC 1 -- ut31 ese324Minor allele frequency- A:0.36NS EA NA WA CSA 903
    rs10572311,2
    C,F,A,H--120113403(-) GAAACA/CTTCCC 1 -- ut3118Minor allele frequency- C:0.14EA NA WA CSA 2071
    rs1501375581,2
    --120113416(+) TGGACA/GCTGGA 1 -- ut310--------
    rs1455297071,2
    --120113436(+) ATGCTA/TTAGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FSTL1 (120111140 - 120170100 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FSTL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669703CNV Deletion23128226
    nsv436396CNV Deletion17901297
    nsv3969CNV Insertion18451855
    esv25295CNV Loss19812545
    nsv877376CNV Gain21882294
    nsv829698CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FSTL1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605547    OMIM disorders: --

    1 disease for FSTL1:    
    About MalaCards
    rheumatoid arthritis


    Find genes that share disorders with FSTL1           About GenesLikeMe

    1 Novoseek inferred disease relationship for FSTL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 28.3 3 15638044 (2), 12502727 (1)

    Genetic Association Database (GAD): FSTL1
    Human Genome Epidemiology (HuGE) Navigator: FSTL1 (3 documents)

    Export disorders for FSTL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FSTL1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with FSTL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. (PubMed id 15638044)1, 2, 4, 9 Ehara Y....Tokunaga K. (Clin. Exp. Rheumatol. 2004)
    2. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. (PubMed id 9786430)1, 2, 3, 9 Tanaka M.... Nakao K. (Int. Immunol. 1998)
    3. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. (PubMed id 7957230)1, 2, 3, 9 Zwijsen A.... Slegers H. (Eur. J. Biochem. 1994)
    4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1, 4 Xu Y....Liu P. (Schizophr. Res. 2010)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis. (PubMed id 18796737)1, 9 Chan Q.K....Cheung A.N. (Carcinogenesis 2009)
    10. Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma. (PubMed id 19109154)1, 9 Clutter S.D....Hirsch R. (J. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11167 HGNC: 3972 AceView: FSTL1 Ensembl:ENSG00000163430 euGenes: HUgn11167
    ECgene: FSTL1 H-InvDB: FSTL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FSTL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FSTL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FSTL1 gene:
    Search GeneIP for patents involving FSTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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