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FST Gene

protein-coding   GIFtS: 66
GCID: GC05P052776

Follistatin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
follistatin1 2
FS2 3 5
Activin-Binding Protein2 3
Follistatin Isoform FST3172

External Ids:    HGNC: 39711   Entrez Gene: 104682   Ensembl: ENSG000001343637   OMIM: 1364705   UniProtKB: P198833   

Export aliases for FST gene to outside databases

Previous GC identifers: GC05P052940 GC05P054206 GC05P052746 GC05P052792 GC05P052812 GC05P049748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FST Gene:
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The
single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively,
resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for
linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was
found for linkage between PCOS and follistatin. (provided by RefSeq, Jul 2008)

GeneCards Summary for FST Gene:
FST (follistatin) is a protein-coding gene. Diseases associated with FST include ovarian endometriosis, and plasmacytoma. GO annotations related to this gene include activin binding and signal transducer activity. An important paralog of this gene is FSTL3.

UniProtKB/Swiss-Prot: FST_HUMAN, P19883
Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis
and secretion of pituitary follicle stimulating hormone (FSH)

Gene Wiki entry for FST (Follistatin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FST gene promoter:
         COUP-TF   COUP   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFST promoter sequence
   Search Chromatin IP Primers for FST

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

FST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FST gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P052776:  view genomic region     (about GC identifiers)

Start:
52,776,239 bp from pter      End:
52,782,964 bp from pter
Size:
6,726 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FST_HUMAN, P19883 (See protein sequence)
Recommended Name: Follistatin precursor  
Size: 344 amino acids; 38007 Da
Subunit: Monomer (Potential)
3 PDB 3D structures from and Proteopedia for FST:
2B0U (3D)        2P6A (3D)        3HH2 (3D)    
Secondary accessions: B5BU94 Q9BTH0
Alternative splicing: 2 isoforms:  P19883-1   P19883-2   

Explore the universe of human proteins at neXtProt for FST: NX_P19883

Explore proteomics data for FST at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn124, Asn288

  • See FST Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006341.1  NP_037541.1  

    ENSEMBL proteins: 
     ENSP00000256759   ENSP00000380151   ENSP00000426315   ENSP00000426971  
    Reactome Protein details: P19883

    FST Human Recombinant Protein Products:

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    Novus Biologicals FST Proteins
    Novus Biologicals FST Lysates
    Sino Biological Recombinant Protein for FST
    Sino Biological Cell Lysate for FST
    ProSpec Recombinant Protein for FST
    Browse Proteins at Cloud-Clone Corp.

    FST Antibody Products:

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    Abcam antibodies for FST
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for FST
    LSBio Antibodies in human, mouse, rat for FST

    FST Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for FST (Follistatin)         (see all)
    GenScript Custom Assay Services for FST
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017878 TB_dom
     IPR002350 Kazal_dom
     IPR015369 Follistatin/Osteonectin_EGF
     IPR003645 Fol_N

    Graphical View of Domain Structure for InterPro Entry P19883

    ProtoNet protein and cluster: P19883

    1 Blocks protein domain: IPB003645 Follistatin-like

    UniProtKB/Swiss-Prot: FST_HUMAN, P19883
    Similarity: Contains 3 follistatin-like domains
    Similarity: Contains 3 Kazal-like domains
    Similarity: Contains 1 TB (TGF-beta binding) domain


    FST for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FST_HUMAN, P19883
    Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis
    and secretion of pituitary follicle stimulating hormone (FSH)

         Genatlas biochemistry entry for FST:
    follistatin,an acitivin-binding protein,expressed in numerous tissues,including the ovary,pituitary,adrenal cortex
    and pancreas,neutralizing the biological acitivity of activin in vivo and in vitro,plausible candidate gene for
    polycystic ovary syndrome PCOS

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity NAS12702211
    GO:0005515protein binding IPI16198295
    GO:0043395heparan sulfate proteoglycan binding IEA--
    GO:0048185activin binding IPI12697670
         
    FST for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fst) (see all 16):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  integument  mortality/aging  muscle 
     nervous system  reproductive system  respiratory system  skeleton  taste/olfaction 

    FST for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fsttm1Zuk for FST

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FST
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FST
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FST

    miRNA
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    Block miRNA regulation of human, mouse, rat FST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FST (see all 34):
    hsa-miR-4307 hsa-miR-624 hsa-miR-298 hsa-miR-3613-3p hsa-miR-330-3p hsa-miR-642b hsa-miR-3163 hsa-miR-4300
    SwitchGear 3'UTR luciferase reporter plasmidFST 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FST
    Predesigned siRNA for gene silencing in human, mouse, rat FST

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FST

    Clone
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    OriGene clones in human, mouse for FST (see all 10)
    OriGene ORF clones in mouse, rat for FST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FST (NM_005860)
    Sino Biological Human cDNA Clone for FST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FST

    Cell Line
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    ESI BIO PureStem Progenitors for FST: 
    PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FST


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FST_HUMAN, P19883: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    FST for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FST About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by NODAL
    Signaling by Activin0.39
    Antagonism of Activin by Follistatin0.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Packaging Of Telomere Ends
    Signal transduction Activin A signaling regulation0.40
    4Signaling by BMP
    BMP receptor signaling0.31
    5TGF Beta Signaling Pathway
    TGF Beta Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FST
        Signal transduction Activin A signaling regulation

    3 BioSystems Pathways for FST
        TGF Beta Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    BMP receptor signaling

    1 Sino Biological Pathway for FST
        TGF-beta Signaling Pathway

    1 Reactome Pathway for FST
        Antagonism of Activin by Follistatin


    1 Kegg Pathway  (Kegg details for FST):
        TGF-beta signaling pathway


    FST for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FST: 
              Estrogen Receptor Signaling in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FST (P198831, 2, 3 ENSP000002567594) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIP2AQ146891, 2, 3, ENSP000003920664EBI-1571188,EBI-2564275 MINT-7991054 MINT-7990792 I2D: score=1 STRING: ENSP00000392066
    C8orf33Q9H7E92, 3MINT-8250396 I2D: score=2 
    TK1P041832, 3MINT-8273455 I2D: score=2 
    ANGP039501, 3, ENSP000003367624EBI-1571188,EBI-525291 I2D: score=1 STRING: ENSP00000336762
    FSTL1Q128412, 3, ENSP000002956334MINT-7990781 I2D: score=1 STRING: ENSP00000295633
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12702211
    GO:0002244hematopoietic progenitor cell differentiation IDA15451575
    GO:0007276gamete generation IEA--
    GO:0007389pattern specification process IEA--
    GO:0008585female gonad development IEA--

    FST for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FST

    1 DrugBank Compound for FST    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-Myo-Inositol-Hexasulphate-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for FST gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    admp 61.9 1 10640703 (1)
    gnrh 58.2 34 7514999 (4), 16618982 (4), 8137764 (4), 8636350 (3) (see all 17)
    ribonucleic acid 54.3 7 7514999 (1), 9360551 (1), 7962340 (1), 9687295 (1) (see all 5)
    progesterone 53.2 50 8384994 (5), 8143902 (5), 8636350 (3), 7517947 (3) (see all 20)
    estradiol 44.1 25 11159377 (3), 8836491 (1), 9396274 (1), 9745445 (1) (see all 16)
    androstenedione 42.3 15 15798024 (3), 7636433 (2), 11726573 (2), 15035548 (1) (see all 8)
    5-aza-2'deoxycytidine 35.7 2 16461556 (1)
    forskolin 32.5 7 7514999 (1), 14636638 (1), 8243277 (1), 8895365 (1) (see all 5)
    testosterone 31.8 10 14761877 (1), 20093255 (1), 11134102 (1), 18000300 (1) (see all 8)
    steroid 29.5 7 8384994 (1), 8836491 (1), 17710734 (1), 18000300 (1) (see all 8)



    FST for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FST gene (2 alternative transcripts): 
    NM_006350.3  NM_013409.2  

    Unigene Cluster for FST:

    Follistatin
    Hs.9914  [show with all ESTs]
    Unigene Representative Sequence: NM_006350
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256759(uc003jpd.3 uc003jpc.3) ENST00000396947 ENST00000491717
    ENST00000504226 ENST00000497789
    miRNA
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    Block miRNA regulation of human, mouse, rat FST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FST (see all 34):
    hsa-miR-4307 hsa-miR-624 hsa-miR-298 hsa-miR-3613-3p hsa-miR-330-3p hsa-miR-642b hsa-miR-3163 hsa-miR-4300
    SwitchGear 3'UTR luciferase reporter plasmidFST 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FST (NM_005860)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FST
      QuantiTect SYBR Green Assays in human, mouse, rat FST
      QuantiFast Probe-based Assays in human, mouse, rat FST

    Additional mRNA sequence: 

    AB451330.1 AB451474.1 BC004107.2 CR541813.1 

    11 DOTS entries:

    DT.91765001  DT.100643647  DT.109260  DT.91655736  DT.95266773  DT.120828863  DT.95075824  DT.95266772 
    DT.91765003  DT.91743591  DT.91892127 

    Selected AceView cDNA sequences (see all 151):

    C00050 BU741873 BQ892406 BU686043 CB157590 AA373240 AI638793 BI862529 
    AW304368 AI633543 BM996782 AI655217 AI002466 CD673267 AI014726 BM683247 
    BM988302 BG116678 BQ182939 BQ026951 BI491000 BQ573838 BM968575 BQ687364 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FST    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:        -                                             
    SP2:                                                      
    SP3:                                                      


    ECgene alternative splicing isoforms for FST

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAAGCTG
    FST Expression
    About this image


    FST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 32) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 7 entries
             Secondary Enamel Knot Cells Enamel Knot
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             mK4
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
    FST Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FST Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9914

    UniProtKB/Swiss-Prot: FST_HUMAN, P19883
    Tissue specificity: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FST: 
              Estrogen Receptor Signaling in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FST
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FST gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fst1 , 5 follistatin1, 5 91.16(n)1
    97.67(a)1
      13 (64.15 cM)5
    143131  NM_008046.21  NP_032072.11 
     1144522625 
    chicken
    (Gallus gallus)
    Aves FST1 follistatin 83.87(n)
    89.5(a)
      396119  NM_205200.1  NP_990531.1 
    lizard
    (Anolis carolinensis)
    Reptilia FST6
    follistatin
    85(a)
    1 ↔ 1
    2(3285448-3306330)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10942 Follistatin 79.52(n)    S69801.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fst2 follistatin 74.81(n)   30235  AF084948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fs6
    Follistatin
    16(a)
    1 → many
    2R(11111061-11129084)


    ENSEMBL Gene Tree for FST (if available)
    TreeFam Gene Tree for FST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FST gene
    FSTL32  
    7 SIMAP similar genes for FST using alignment to 4 protein entries:     FST_HUMAN (see all proteins):
    FSTL3    DKFZp566D234    SPINK4    tmp_locus_3    FSTL4    AGRN
    WUGSC

    FST for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FST (see all 157)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745385571,2
    C,F--49746453(+) AATGTC/TGTCTG 2 -- us2k11Minor allele frequency- T:0.07NA 120
    rs790130931,2
    C--49746554(+) GGAGAG/CTACGG 2 -- us2k14Minor allele frequency- C:0.12CSA WA EA 241
    rs1502226391,2
    --49746626(+) GAGGGA/TATGAG 2 -- us2k10--------
    rs623704801,2
    C,F--49746631(+) AATGAG/ATTGGA 2 -- us2k13Minor allele frequency- A:0.25NA 124
    rs1380826791,2
    C--49746757(+) CCAGTA/C/TTCCCC 2 -- us2k10--------
    rs1436304991,2
    --49747256(+) CCAAGA/GATTTT 2 -- us2k10--------
    rs761370761,2
    F--49747575(+) GAGCCG/CAGGAG 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1469786761,2
    C--49747587(+) CTGAG-/AGAC  
            
    AGACA
    2 -- us2k10--------
    rs1843462911,2
    C--49747621(+) TGGGGA/CGTCTC 2 -- us2k10--------
    rs1150025701,2
    C,F--49747730(+) GGAGAG/AGGCGA 2 -- us2k12Minor allele frequency- A:0.05WA EA 238

    HapMap Linkage Disequilibrium report for FST (52776239 - 52782964 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FST:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv328038CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FST
    DNA2.0 Custom Variant and Variant Library Synthesis for FST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136470    OMIM disorders: --

    Selected diseases for FST (see all 50):    
    About MalaCards
    ovarian endometriosis    plasmacytoma    acute liver failure    polycystic ovary syndrome
    folliculitis    teratocarcinoma    hypertrophic scars    endometriosis
    prostate disease    endometrial adenocarcinoma    pituitary tumors    azoospermia
    choriocarcinoma    meningitis    down syndrome    viral hepatitis
    pre-eclampsia    pituitary adenoma    eclampsia    infertility

    1 disease from the University of Copenhagen DISEASES database for FST:
    Polycystic ovary syndrome

    FST for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FST gene (see all 49)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polycystic ovary syndrome 55.7 19 20093255 (2), 19591997 (2), 11726573 (2), 10411917 (1) (see all 14)
    infertility female 42.6 1 17932109 (1)
    atresia 42.2 9 8418903 (2), 8567852 (2), 8329651 (1), 7991780 (1)
    preeclampsia 27.4 18 10750046 (4), 11814508 (3), 12651901 (2), 14728855 (2) (see all 8)
    polycystic ovaries 24.1 1 8567852 (1)
    leukemia b-cell 22.5 2 15451575 (1)
    miscarriage recurrent 18.6 5 17074342 (4), 12456605 (1)
    pituitary adenoma 16.4 3 11318784 (2), 11414477 (1)
    teratocarcinoma 11.8 3 8636347 (2), 8389547 (1)
    prostate cancer 10.7 11 9360551 (3), 10081911 (2), 8940339 (1), 8940374 (1) (see all 7)

    Genetic Association Database (GAD): FST
    Human Genome Epidemiology (HuGE) Navigator: FST (39 documents)

    Export disorders for FST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FST gene, integrated from 10 sources (see all 430):
    (articles sorted by number of sources associating them with FST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of the human follistatin precursor and its genomic organization. (PubMed id 3380788)1, 2, 3 Shimasaki S.... Guillemin R. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    2. Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay. (PubMed id 15472207)1, 2, 9 Schneyer A.L.... Sluss P.M. (J. Clin. Endocrinol. Metab. 2004)
    3. Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity. (PubMed id 19346981)1, 4, 9 Kostek M.A....Pescatello L.S. (Med Sci Sports Exerc 2009)
    4. Polymorphism of the follistatin gene in polycystic ovary syndrome. (PubMed id 17284512)1, 4, 9 Jones M.R....Stuckey B.G. (Mol. Hum. Reprod. 2007)
    5. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. (PubMed id 10411917)1, 3, 9 Urbanek M....Dunaif A. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    6. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    7. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    10. The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. (PubMed id 16198295)1, 2 Thompson T.B.... Jardetzky T.S. (Dev. Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10468 HGNC: 3971 AceView: FST Ensembl:ENSG00000134363 euGenes: HUgn10468
    ECgene: FST Kegg: 10468 H-InvDB: FST

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FST Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FST Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FST gene:
    Search GeneIP for patents involving FST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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