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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FST Gene

protein-coding   GIFtS: 66
GCID: GC05P052776

Follistatin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
follistatin1 2
FS2 3 5
Activin-Binding Protein2 3
Follistatin Isoform FST3172

External Ids:    HGNC: 39711   Entrez Gene: 104682   Ensembl: ENSG000001343637   OMIM: 1364705   UniProtKB: P198833   

Export aliases for FST gene to outside databases

Previous GC identifers: GC05P052940 GC05P054206 GC05P052746 GC05P052792 GC05P052812 GC05P049748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FST Gene:
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The
single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively,
resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for
linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was
found for linkage between PCOS and follistatin. (provided by RefSeq, Jul 2008)

GeneCards Summary for FST Gene: 
FST (follistatin) is a protein-coding gene. Diseases associated with FST include ovarian endometriosis, and acute liver failure, and among its related super-pathways are Signaling by Activin and Signaling by GPCR. GO annotations related to this gene include activin binding and signal transducer activity. An important paralog of this gene is FSTL3.

UniProtKB/Swiss-Prot: FST_HUMAN, P19883
Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis
and secretion of pituitary follicle stimulating hormone (FSH)

Gene Wiki entry for FST (Follistatin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FST gene promoter:
         COUP-TF   COUP   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFST promoter sequence
   Search SABiosciences Chromatin IP Primers for FST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

FST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FST gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P052776:  view genomic region     (about GC identifiers)

Start:
52,776,239 bp from pter      End:
52,782,964 bp from pter
Size:
6,726 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FST_HUMAN, P19883 (See protein sequence)
Recommended Name: Follistatin precursor  
Size: 344 amino acids; 38007 Da
Subunit: Monomer (Potential)
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for FST:
2B0U (3D)        2P6A (3D)        3HH2 (3D)    
Secondary accessions: B5BU94 Q9BTH0
Alternative splicing: 2 isoforms:  P19883-1   P19883-2   

Explore the universe of human proteins at neXtProt for FST: NX_P19883

Explore proteomics data for FST at MOPED 

FST Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FST Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_006341.1  NP_037541.1  

ENSEMBL proteins: 
 ENSP00000256759   ENSP00000380151   ENSP00000426315   ENSP00000426971  
Reactome Protein details: P19883
Human Recombinant Protein Products for FST: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for FST (Follistatin)
Browse recombinant and purified proteins available from Enzo Life Sciences
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OriGene Protein Over-expression Lysate for FST
OriGene MassSpec for FST 
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GenScript Custom Purified and Recombinant Proteins Services for FST
Novus Biologicals FST Proteins
Novus Biologicals FST Lysates
Sino Biological Recombinant Protein for FST
Sino Biological Cell Lysate for FST 
ProSpec Recombinant Protein for FST
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005634nucleus IEA--
GO:0005737cytoplasm IEA--

FST for ontologies           About GeneDecksing



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Abcam antibodies for FST
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ThermoFisher Antibodies for FST
LSBio Antibodies in human, mouse, rat for FST 

Assay Products for FST: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for FST
R&D Systems ELISAs for FST (Follistatin)         (see all)
GenScript Custom Assay Services for FST
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Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR017878 TB_dom
 IPR002350 Kazal_dom
 IPR015369 Follistatin/Osteonectin_EGF
 IPR003645 Fol_N

Graphical View of Domain Structure for InterPro Entry P19883

ProtoNet protein and cluster: P19883

1 Blocks protein domain: IPB003645 Follistatin-like

UniProtKB/Swiss-Prot: FST_HUMAN, P19883
Similarity: Contains 3 follistatin-like domains
Similarity: Contains 3 Kazal-like domains
Similarity: Contains 1 TB (TGF-beta binding) domain


FST for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: FST_HUMAN, P19883
Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis
and secretion of pituitary follicle stimulating hormone (FSH)

     Genatlas biochemistry entry for FST:
follistatin,an acitivin-binding protein,expressed in numerous tissues,including the ovary,pituitary,adrenal cortex
and pancreas,neutralizing the biological acitivity of activin in vivo and in vitro,plausible candidate gene for
polycystic ovary syndrome PCOS

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004871signal transducer activity NAS12702211
GO:0005515protein binding IPI16198295
GO:0043395heparan sulfate proteoglycan binding IEA--
GO:0048185activin binding IPI12697670
     
FST for ontologies           About GeneDecksing


Phenotypes:
     15/16 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fst) (see all 16):
 cardiovascular system  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
 growth/size  homeostasis/metabolism  integument  mortality/aging  muscle 
 nervous system  reproductive system  respiratory system  skeleton  taste/olfaction 

FST for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Fsttm1Zuk for FST

   inGenious Targeting Laboratory - Custom generated mouse model solutions for FST 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FST

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FST 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FST 

miRNA
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8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FST (see all 34):
hsa-miR-4307 hsa-miR-624 hsa-miR-298 hsa-miR-3613-3p hsa-miR-330-3p hsa-miR-642b hsa-miR-3163 hsa-miR-4300
SwitchGear 3'UTR luciferase reporter plasmidFST 3' UTR sequence
Inhib. RNA
Products:
    
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FST

Gene Editing
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Clone
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OriGene clones in human, mouse for FST (see all 12)
OriGene ORF clones in mouse, rat for FST
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FST (NM_005860)
Sino Biological Human cDNA Clone for FST
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FST
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FST
Sirion Biotech Customized lentivirus for stable overexpression of FST 
                     Customized lentivirus expression plasmids for stable overexpression of FST 

Cell Line
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LifeMap BioReagents: cell lines associated with FST: PureStem 7SMOO32, NCr-fac & Meso Progenitor,
PureStem SM30, NCr-fac & Meso-latp Progenitor
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FST


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for FST About   (see all 8)                                                                                              See pathways by source

SuperPathContained pathways About
1Signaling by NODAL
Signaling by Activin0.36
Antagonism of Activin by Follistatin0.33
2Signaling by GPCR
Signal Transduction0.55
3Signal transduction Activin A signaling regulation
Signal transduction Activin A signaling regulation0.31
4Signaling by BMP
BMP receptor signaling0.31
5TGF-beta signaling pathway
TGF-beta signaling pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for FST
    Signal transduction Activin A signaling regulation


1 GeneGo (Thomson Reuters) Pathway for FST
    Signal transduction Activin A signaling regulation

3 BioSystems Pathways for FST
    TGF Beta Signaling Pathway
Integrated Pancreatic Cancer Pathway
BMP receptor signaling

1 Sino Biological Pathway for FST 
    TGF-beta Signaling Pathway

3        Reactome Pathways for FST
    Signaling by Activin
Signal Transduction
Antagonism of Activin by Follistatin


1         Kegg Pathway  (Kegg details for FST):
    TGF-beta signaling pathway


FST for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FST

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/29 Interacting proteins for FST (P198831, 2, 3 ENSP000002567594) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
InteractantInteraction Details
GeneCardExternal ID(s)
DIP2AQ146892, 3, ENSP000003920664MINT-7991054 MINT-7990792 I2D: score=1 STRING: ENSP00000392066
C8orf33Q9H7E92, 3MINT-8250396 I2D: score=2 
TK1P041832, 3MINT-8273455 I2D: score=2 
ANGP039501, 3, ENSP000003367624EBI-1571188,EBI-525291 I2D: score=1 STRING: ENSP00000336762
FSTL1Q128412, 3, ENSP000002956334MINT-7990781 I2D: score=1 STRING: ENSP00000295633
About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12702211
GO:0002244hematopoietic progenitor cell differentiation IDA15451575
GO:0007276gamete generation IEA--
GO:0007389pattern specification process IEA--
GO:0008585female gonad development IEA--

FST for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FST for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FST

1 DrugBank Compound for FST    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
D-Myo-Inositol-Hexasulphate-- --target--10592235

10/45 Novoseek inferred chemical compound relationships for FST gene (see all 45)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
admp 61.9 1 10640703 (1)
gnrh 58.2 34 7514999 (4), 16618982 (4), 8137764 (4), 8636350 (3) (see all 17)
ribonucleic acid 54.3 7 7514999 (1), 9360551 (1), 7962340 (1), 9687295 (1) (see all 5)
progesterone 53.2 50 8384994 (5), 8143902 (5), 8636350 (3), 7517947 (3) (see all 20)
estradiol 44.1 25 11159377 (3), 8836491 (1), 9396274 (1), 9745445 (1) (see all 16)
androstenedione 42.3 15 15798024 (3), 7636433 (2), 11726573 (2), 15035548 (1) (see all 8)
5-aza-2'deoxycytidine 35.7 2 16461556 (1)
forskolin 32.5 7 7514999 (1), 14636638 (1), 8243277 (1), 8895365 (1) (see all 5)
testosterone 31.8 10 14761877 (1), 20093255 (1), 11134102 (1), 18000300 (1) (see all 8)
steroid 29.5 7 8384994 (1), 8836491 (1), 17710734 (1), 18000300 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about FST

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FST gene (2 alternative transcripts): 
NM_006350.3  NM_013409.2  

Unigene Cluster for FST:

Follistatin
Hs.9914  [show with all ESTs]
Unigene Representative Sequence: NM_006350
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000256759(uc003jpd.3 uc003jpc.3) ENST00000396947 ENST00000491717
ENST00000504226 ENST00000497789
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FST
8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FST (see all 34):
hsa-miR-4307 hsa-miR-624 hsa-miR-298 hsa-miR-3613-3p hsa-miR-330-3p hsa-miR-642b hsa-miR-3163 hsa-miR-4300
SwitchGear 3'UTR luciferase reporter plasmidFST 3' UTR sequence
Inhib. RNA
Products:
     
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Clone
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GenScript: all cDNA clones in your preferred vector: FST (NM_005860)
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Sirion Biotech Customized lentivirus for stable overexpression of FST 
                     Customized lentivirus expression plasmids for stable overexpression of FST 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FST
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FST

Additional mRNA sequence: 

AB451330.1 AB451474.1 BC004107.2 CR541813.1 

11 DOTS entries:

DT.91765001  DT.100643647  DT.109260  DT.91655736  DT.95266773  DT.120828863  DT.95075824  DT.95266772 
DT.91765003  DT.91743591  DT.91892127 

24/151 AceView cDNA sequences (see all 151):

AI168319 BU686043 BQ687266 AI038613 AW450588 BU741873 CB157590 AA384360 
AI014726 BQ685242 CA419263 BM968575 BF195586 BU742844 BQ573838 BI862529 
BG116678 AI638793 BM683247 CD673267 AA373240 BQ182939 BQ892406 BF223132 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FST    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1:        -                                             
SP2:                                                      
SP3:                                                      


ECgene alternative splicing isoforms for FST

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FST expression in normal human tissues (normalized intensities)      FST embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGGAAGCTG
FST Expression
About this image


FST expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/41 selected tissues (see all 41) fully expand
 
 Tooth (Integumentary System)    fully expand to see all 8 entries
         Secondary Enamel Knot Cells Enamel Knot
         Dental pulp Stem Cells (DPSC)   
         visceral organ/oral region/upper jaw   
 
 Limb (Muscoskeletal System)    fully expand to see all 6 entries
         Mesenchymal Condensate Cells Zeugopod
         Zeugopod
         limb/hindlimb/leg   
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
         Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
         cavities and their linings/intraembryonic coelom/diaphragm   
 
 Fibroblast
         Human Lymphatic Fibroblasts (HLF)   
 
 Bone (Muscoskeletal System)    fully expand to see all 4 entries
         Mesenchymal Condensate Cells Zeugopod
         Zeugopod Long Bone
         Human fetal bone marrow-derived mesenchymal stromal cells
         Normal Human osteoblasts (NHOST)   

See FST Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FST

SOURCE GeneReport for Unigene cluster: Hs.9914

UniProtKB/Swiss-Prot: FST_HUMAN, P19883
Tissue specificity: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid

    SABiosciences Expression via Pathway-Focused PCR Arrays including FST: 
          Estrogen Receptor Signaling in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          WNT Signaling Targets in human mouse rat
          TGFB/BMP Signaling Pathway in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FST
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FST

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FST gene from 6/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fst1 , 5 follistatin1, 5 91.16(n)1
97.67(a)1
  13 (64.15 cM)5
143131  NM_008046.21  NP_032072.11 
 1144522625 
chicken
(Gallus gallus)
Aves FST1 follistatin 83.97(n)
89.8(a)
  396119  NM_205200.1  NP_990531.1 
lizard
(Anolis carolinensis)
Reptilia FST6
Uncharacterized protein
85(a)
1 ↔ 1
2(3285448-3306330)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10942 Follistatin 79.52(n)    S69801.1 
zebrafish
(Danio rerio)
Actinopterygii fst2 follistatin 74.81(n)   30235  AF084948.1 
fruit fly
(Drosophila melanogaster)
Insecta Fs1 Follistatin 47.34(n)
41.41(a)
  2768836  NM_144119.2  NP_652376.2 


ENSEMBL Gene Tree for FST (if available)
TreeFam Gene Tree for FST (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FST gene
FSTL32  
6 SIMAP similar genes for FST using alignment to 4 protein entries:     FST_HUMAN (see all proteins):
FSTL3    DKFZp566D234    SPINK4    tmp_locus_3    FSTL4    WUGSC

FST for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/157 SNPs in FST are shown (see all 157)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs745385571,2
C,F--49746453(+) AATGTC/TGTCTG 2 -- us2k11Minor allele frequency- T:0.07NA 120
rs790130931,2
C--49746554(+) GGAGAG/CTACGG 2 -- us2k14Minor allele frequency- C:0.12CSA WA EA 241
rs1502226391,2
--49746626(+) GAGGGA/TATGAG 2 -- us2k10--------
rs623704801,2
C,F--49746631(+) AATGAG/ATTGGA 2 -- us2k13Minor allele frequency- A:0.25NA 124
rs1380826791,2
C--49746757(+) CCAGTA/C/TTCCCC 2 -- us2k10--------
rs1436304991,2
--49747256(+) CCAAGA/GATTTT 2 -- us2k10--------
rs761370761,2
F--49747575(+) GAGCCG/CAGGAG 2 -- us2k11Minor allele frequency- C:0.01NA 120
rs1469786761,2
C--49747587(+) CTGAG-/AGAC  
        
AGACA
2 -- us2k10--------
rs1843462911,2
C--49747621(+) TGGGGA/CGTCTC 2 -- us2k10--------
rs1150025701,2
C,F--49747730(+) GGAGAG/AGGCGA 2 -- us2k12Minor allele frequency- A:0.05WA EA 238

HapMap Linkage Disequilibrium report for FST (52776239 - 52782964 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for FST:    About this table     
Variant IDTypeSubtypePubMed ID
nsv328038CNV Loss16902084

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 136470   
OMIM disorders: 184700  
20/50 diseases for FST (see all 50):    About MalaCards
ovarian endometriosis    acute liver failure    polycystic ovary syndrome    teratocarcinoma
prostate disease    plasmacytoma    endometriosis    hypertrophic scars
azoospermia    pituitary tumors    endometrial adenocarcinoma    folliculitis
choriocarcinoma    meningitis    viral hepatitis    pre-eclampsia
prostate cancer, progression of    down syndrome    pituitary adenoma    eclampsia

1 disease from the University of Copenhagen DISEASES database for FST:
Polycystic ovary syndrome

FST for disorders           About GeneDecksing

10/49 Novoseek inferred disease relationships for FST gene (see all 49)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
polycystic ovary syndrome 55.7 19 20093255 (2), 19591997 (2), 11726573 (2), 10411917 (1) (see all 14)
infertility female 42.6 1 17932109 (1)
atresia 42.2 9 8418903 (2), 8567852 (2), 8329651 (1), 7991780 (1)
preeclampsia 27.4 18 10750046 (4), 11814508 (3), 12651901 (2), 14728855 (2) (see all 8)
polycystic ovaries 24.1 1 8567852 (1)
leukemia b-cell 22.5 2 15451575 (1)
miscarriage recurrent 18.6 5 17074342 (4), 12456605 (1)
pituitary adenoma 16.4 3 11318784 (2), 11414477 (1)
teratocarcinoma 11.8 3 8636347 (2), 8389547 (1)
prostate cancer 10.7 11 9360551 (3), 10081911 (2), 8940339 (1), 8940374 (1) (see all 7)

Genetic Association Database (GAD): FST
Human Genome Epidemiology (HuGE) Navigator: FST (39 documents)

Export disorders for FST gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FST gene, integrated from 9 sources (see all 424):
(articles sorted by number of sources associating them with FST)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Primary structure of the human follistatin precursor and its genomic organization. (PubMed id 3380788)1, 2, 3 Shimasaki S.... Guillemin R. (1988)
  2. Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay. (PubMed id 15472207)1, 2, 9 Schneyer A.L.... Sluss P.M. (2004)
  3. Myostatin and Follistatin Polymorphisms Interact with Muscle Phenotypes and Ethnicity. (PubMed id 19346981)1, 4, 9 Kostek M.A....Pescatello L.S. (2009)
  4. Polymorphism of the follistatin gene in polycystic ovary syndrome. (PubMed id 17284512)1, 4, 9 Jones M.R....Stuckey B.G. (2007)
  5. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. (PubMed id 10411917)1, 3, 9 Urbanek M....Dunaif A. (1999)
  6. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
  7. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
  8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
  9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
  10. The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. (PubMed id 16198295)1, 2 Thompson T.B.... Jardetzky T.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10468 HGNC: 3971 AceView: FST Ensembl:ENSG00000134363 euGenes: HUgn10468
ECgene: FST Kegg: 10468 H-InvDB: FST

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FST Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FST Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FST gene:
Search GeneIP for patents involving FST

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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