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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FST Gene

protein-coding GIFtS: 68
GCID: GC05P052776

follistatin

Explore 47 diseases affiliated with
FST via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Follistatin¹
FS¹ ² ³ ⁵
Activin-Binding Protein² ³
Follistatin Isoform FST317²

External Ids:	HGNC: 3971¹	Entrez Gene: 10468²	Ensembl: ENSG00000134363⁷	OMIM: 136470⁵	UniProtKB: P19883³

Export aliases for FST gene to outside databases

Previous GC identifers: GC05P052940 GC05P054206 GC05P052746 GC05P052792 GC05P052812 GC05P049748

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FST:

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The

single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting

from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and

association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage

between PCOS and follistatin. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FST_HUMAN, P19883

Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and

secretion of pituitary follicle stimulating hormone (FSH)

Gene Wiki entry for FST (Follistatin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FST gene promoter:
COUP-TF COUP MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FST promoter sequence

Search SABiosciences Chromatin IP Primers for FST

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FST

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

FST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FST gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P052776: view genomic region (about GC identifiers)

Start:	52,776,239 bp from pter	End:	52,782,964 bp from pter
Size:	6,726 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FST_HUMAN, P19883 (See protein sequence)

Recommended Name: Follistatin precursor

Size: 344 amino acids; 38007 Da

Subunit: Monomer (Potential)

Subcellular location: Secreted

3 PDB 3D structures from and Proteopedia for FST:

2B0U (3D)

2P6A (3D)

3HH2 (3D)

Secondary accessions: B5BU94 Q9BTH0

Alternative splicing: 2 isoforms: P19883-1 P19883-2

Explore the universe of human proteins at neXtProt for FST: NX_P19883

FST Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_006341.1 NP_037541.1

ENSEMBL proteins:

ENSP00000256759 ENSP00000423508 ENSP00000380151 ENSP00000426315 ENSP00000426971

Reactome Protein details: P19883
Human Recombinant Protein Products:

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	Novus Biologicals FST Proteins Novus Biologicals FST Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for FST
	Uscn Proteins for FST

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

FST for ontologies About GeneDecksing

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	Uscn Antibodies for FST
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Assay Products for FST:

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	Uscn ELISAs and CLIAs for FST

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FST for domains About GeneDecksing

4 InterPro domains/families:

IPR017878 TB_dom

IPR002350 Prot_inh_Kazal

IPR015369 Follistatin/Osteonectin_EGF

IPR003645 Fol_N

Graphical View of Domain Structure for InterPro Entry P19883

ProtoNet protein and cluster: P19883

1 Blocks protein family: IPB003645 Follistatin-like

UniProtKB/Swiss-Prot: FST_HUMAN, P19883

Similarity: Contains 3 follistatin-like domains

Similarity: Contains 3 Kazal-like domains

Similarity: Contains 1 TB (TGF-beta binding) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FST_HUMAN, P19883

Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and

secretion of pituitary follicle stimulating hormone (FSH)

Genatlas biochemistry entry for FST:

follistatin,an acitivin-binding protein,expressed in numerous tissues,including the ovary,pituitary,adrenal cortex and

pancreas,neutralizing the biological acitivity of activin in vivo and in vitro,plausible candidate gene for polycystic

ovary syndrome PCOS

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FST
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FST (see all 34):
		hsa-miR-4307 hsa-miR-624 hsa-miR-298 hsa-miR-3613-3p hsa-miR-330-3p hsa-miR-642b hsa-miR-3163 hsa-miR-4300

		SwitchGear 3'UTR luciferase reporter plasmid: FST 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FST

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	NAS	12702211
GO:0005515	protein binding	IPI	17991437
GO:0043395	heparan sulfate proteoglycan binding	IEA	--
GO:0048185	activin binding	IPI	12697670

FST for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Fst^tm1Zuk for FST
     15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fst) (see all 16):

cardiovascular system	cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	integument	mortality/aging	muscle
nervous system	reproductive system	respiratory system	skeleton	taste/olfaction

FST for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signal transduction Activin A signaling regulation

Signal transduction Activin A signaling regulation

1.00

Signal transduction_Activin A signaling regulation

0.96

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Signaling by NODAL

Signaling by Activin

0.36

Antagonism of Activin by Follistatin

0.00

TGF Beta Signaling Pathway

TGF Beta Signaling Pathway

1.00

TGF-beta signaling pathway

TGF-beta signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FST

Signal transduction Activin A signaling regulation

1 GeneGo (Thomson Reuters) Pathway for FST

Signal transduction Activin A signaling regulation

4 BioSystems Pathways for FST

	TGF Beta Signaling Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	BMP receptor signaling

3 Reactome Pathways for FST

	Signaling by Activin
	Signal Transduction
	Antagonism of Activin by Follistatin

1 Kegg Pathway (Kegg details for FST):

TGF-beta signaling pathway

FST for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FST

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/29 Interacting proteins for FST (P19883^{1, 2, 3} ENSP00000256759⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DIP2A	Q14689²^,³, ENSP00000392066⁴	MINT-7991054 MINT-7990792 I2D: score=1 STRING: ENSP00000392066
C8orf33	Q9H7E9²^,³	MINT-8250396 I2D: score=2
TK1	P04183²^,³	MINT-8273455 I2D: score=2
ANG	P03950¹^,³, ENSP00000336762⁴	EBI-1571188,EBI-525291 I2D: score=1 STRING: ENSP00000336762
FSTL1	Q12841²^,³, ENSP00000295633⁴	MINT-7990781 I2D: score=1 STRING: ENSP00000295633

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	12702211
GO:0002244	hematopoietic progenitor cell differentiation	IDA	15451575
GO:0007165	signal transduction	--	--
GO:0007276	gamete generation	IEA	--
GO:0007389	pattern specification process	IEA	--

FST for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FST for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FST

1 DrugBank Compound for FST About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
D-Myo-Inositol-Hexasulphate	--	--	target	--	10592235

10/45 Novoseek chemical compound relationships for FST gene (see all 45) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
admp	61.9	1	10640703 (1)
gnrh	58.2	34	7514999 (4), 16618982 (4), 8137764 (4), 8636350 (3) (see all 17)
ribonucleic acid	54.3	7	7514999 (1), 9360551 (1), 7962340 (1), 9687295 (1) (see all 5)
progesterone	53.2	50	8384994 (5), 8143902 (5), 8636350 (3), 7517947 (3) (see all 20)
estradiol	44.1	25	11159377 (3), 8836491 (1), 9396274 (1), 9745445 (1) (see all 16)
androstenedione	42.3	15	15798024 (3), 7636433 (2), 11726573 (2), 15035548 (1) (see all 8)
5-aza-2'deoxycytidine	35.7	2	16461556 (1)
forskolin	32.5	7	7514999 (1), 14636638 (1), 8243277 (1), 8895365 (1) (see all 5)
testosterone	31.8	10	14761877 (1), 20093255 (1), 11134102 (1), 18000300 (1) (see all 8)
steroid	29.5	7	8384994 (1), 8836491 (1), 17710734 (1), 18000300 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about FST

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FST gene (2 alternative transcripts):

NM_006350.3 NM_013409.2

Unigene Cluster for FST:

Follistatin

Hs.9914 [show with all ESTs]

Unigene Representative Sequence: NM_006350

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000256759(uc003jpd.3 uc003jpc.3) ENST00000511025 ENST00000396947

ENST00000491717 ENST00000504226 ENST00000497789

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FST
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FST (see all 34):
		hsa-miR-4307 hsa-miR-624 hsa-miR-298 hsa-miR-3613-3p hsa-miR-330-3p hsa-miR-642b hsa-miR-3163 hsa-miR-4300

		SwitchGear 3'UTR luciferase reporter plasmid: FST 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FST

Additional cDNA sequence:

AB451330.1 AB451474.1 BC004107.2 CR541813.1

11 DOTS entries:

DT.91765001 DT.100643647 DT.109260 DT.91655736 DT.95266773 DT.120828863 DT.95075824 DT.95266772

DT.91765003 DT.91743591 DT.91892127

24/151 AceView cDNA sequences (see all 151):

AI014726 NM_013409 BQ687364 BM681377 BQ182939 BM996782 AA236842 AA384360

CB157590 BI862529 C00050 AW304368 AI655217 BM683247 AW293745 BC004107

BU741873 AI638793 BI491000 BQ026951 AW450588 BQ685242 BQ687266 CN485274

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FST About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6
SP1:			-
SP2:
SP3:

ECgene alternative splicing isoforms for FST

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FST expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAAGCTG

About this image

FST expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Hypoblast

Parietal Endoderm Cells

Extraembryonic Tissues

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Somite

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Bone

Eye

Eye

Kidney

Limb

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/15 LifeMap Cells (see all 15)

Name

Category

mK4 (Cell line)

Kidney

mK3 (Cell line)

Kidney

Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)

Extraembryonic Tissues

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

See FST Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FST

SOURCE GeneReport for Unigene cluster: Hs.9914

UniProtKB/Swiss-Prot: FST_HUMAN, P19883

Tissue specificity: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid

SABiosciences Expression via Pathway-Focused PCR Arrays including FST:

Estrogen Receptor Signaling in human mouse rat

Angiogenic Growth Factors in human mouse rat

WNT Signaling Targets in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FST gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fst^{1 , 5}	follistatin^{1, 5}	91.16(n)¹ 97.67(a)¹		13 (64.15 cM)⁵ 14313¹ NM_008046.2¹ NP_032072.1¹ 114452262⁵
chicken (Gallus gallus)	Aves	FST¹	follistatin	83.97(n) 89.8(a)		396119 NM_205200.1 NP_990531.1
lizard (Anolis carolinensis)	Reptilia	FST⁶	--	85(a)	1 ↔ 1	2(3288078-3305923)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1094²	Follistatin	79.52(n)		S69801.1
zebrafish (Danio rerio)	Actinopterygii	fst²	follistatin	74.81(n)		30235 AF084948.1
fruit fly (Drosophila melanogaster)	Insecta	Fs¹	Follistatin	47.34(n) 41.41(a)		2768836 NM_144119.2 NP_652376.2

ENSEMBL Gene Tree for FST (if available)
TreeFam Gene Tree for FST (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FST gene

FSTL3²

8 SIMAP similar genes for FST using alignment to 5 protein entries: FST_HUMAN (see all proteins):

FSTL3 DKFZp566D234 AGRN FSTL1 SPINK4 tmp_locus_3

FSTL4 WUGSC

FST for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74538557^1,2	F,	--	49746453(+)	`AATGTC/TGTCTG`	2	--	us2k¹		1		NA	120
rs62370480^1,2	C,F,	--	49746631(+)	`AATGAG/ATTGGA`	2	--	us2k¹		3		NA	124
rs76137076^1,2		--	49747575(+)	`GAGCCG/CAGGAG`	2	--	us2k¹		1		NA	120
rs115002570^1,2	C,F,	--	49747730(+)	`GGAGAG/AGGCGA`	2	--	us2k¹		2		WA EA	238
rs3806901^1,2	C,	--	49747944(+)	`CCCAGG/ACTGCG`	2	--	us2k¹		3		CSA WA EA	240
rs12652673^1,2	C,H	--	49748991(+)	`ATGACA/CCTTTA`	2	--	int¹		2		NS NA	228
rs55744247^1,2	C,	--	49749987(+)	`GGCGCG/AGAGGA`	2	--	int¹		3		NA	124
rs76803798^1,2		--	49750385(+)	`CTACAG/TGAAAC`	2	--	int¹		0	--	--	--	--
rs117244832^1,2	C,F,	--	49752337(+)	`AAGGCG/ATCCCC`	2	--	int¹		1		EA	120
rs8434^1,2	H	--	49753939(-)	`GTCTTC/AATCTT`	3	/E /*	ut3¹ stg¹		5		NS EA NA	398

HapMap Linkage Disequilibrium report for FST (52776239 - 52782964 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FST
1 CNV: 6399

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FST

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FST for disorders           About GeneDecksing

OMIM gene information: 136470
OMIM disorders: 184700
20/47 diseases for FST (see all 47):    About MalaCards

polycystic ovary syndrome pre-eclampsia pituitary adenoma insulin resistance

plasmacytoma acute liver failure pituitary tumor down syndrome

teratocarcinoma azoospermia viral hepatitis endometrial carcinoma

endometriosis infertility meningitis ovarian endometriosis

eclampsia choriocarcinoma adenoma hepatocellular carcinoma

1 disease from the University of Copenhagen DISEASES database for FST:

Polycystic ovary syndrome

10/49 Novoseek disease relationships for FST gene (see all 49) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
polycystic ovary syndrome	55.7	19	20093255 (2), 19591997 (2), 11726573 (2), 10411917 (1) (see all 14)
infertility female	42.6	1	17932109 (1)
atresia	42.2	9	8418903 (2), 8567852 (2), 8329651 (1), 7991780 (1)
preeclampsia	27.4	18	10750046 (4), 11814508 (3), 12651901 (2), 14728855 (2) (see all 8)
polycystic ovaries	24.1	1	8567852 (1)
leukemia b-cell	22.5	2	15451575 (1)
miscarriage recurrent	18.6	5	17074342 (4), 12456605 (1)
pituitary adenoma	16.4	3	11318784 (2), 11414477 (1)
teratocarcinoma	11.8	3	8636347 (2), 8389547 (1)
prostate cancer	10.7	11	9360551 (3), 10081911 (2), 8940339 (1), 8940374 (1) (see all 7)

Genetic Association Database (GAD): FST
Human Genome Epidemiology (HuGE) Navigator: FST (39 documents)

Export disorders for FST gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FST gene, integrated from 9 sources (see all 421):
(articles sorted by number of sources associating them with FST)

Utopia: connect your pdf to the dynamic
world of online information

Primary structure of the human follistatin precursor and its genomic organization. (PubMed id 3380788)^{1, 2, 3} Shimasaki S.... Guillemin R. (1988)
Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay. (PubMed id 15472207)^{1, 2, 9} Schneyer A.L.... Sluss P.M. (2004)
Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. (PubMed id 10411917)^{1, 3, 9} Urbanek M....Dunaif A. (1999)
The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. (PubMed id 16198295)^{1, 2} Thompson T.B.... Jardetzky T.S. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus. (PubMed id 11232039)^{1, 4} Tucci S....Tomer Y. (2001)
Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice. (PubMed id 18245525)^{1, 9} Ogino H....Sone S. (2008)
A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin. (PubMed id 16336961)^{1, 9} Maguer-Satta V....Rimokh R. (2006)
Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins. (PubMed id 16627583)^{1, 9} Sidis Y....Schneyer A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10468	HGNC: 3971	AceView: FST	Ensembl:ENSG00000134363	euGenes: HUgn10468
ECgene: FST	Kegg: 10468	H-InvDB: FST

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FST	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FST gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FST gene:
Search GeneIP for patents involving FST

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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