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Aliases for FST Gene

Aliases for FST Gene

  • Follistatin 2 3 5
  • Activin-Binding Protein 3 4
  • FS 3 4
  • Follistatin Isoform FST317 3

External Ids for FST Gene

Previous GeneCards Identifiers for FST Gene

  • GC05P052940
  • GC05P054206
  • GC05P052746
  • GC05P052792
  • GC05P052812
  • GC05P049748
  • GC05P052776

Summaries for FST Gene

Entrez Gene Summary for FST Gene

  • Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]

GeneCards Summary for FST Gene

FST (Follistatin) is a Protein Coding gene. Diseases associated with FST include Polycystic Ovary Syndrome and Adult Spinal Muscular Atrophy. Among its related pathways are Signaling by NODAL and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include signal transducer activity and activin binding. An important paralog of this gene is FSTL3.

UniProtKB/Swiss-Prot for FST Gene

  • Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Gene Wiki entry for FST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FST Gene

Genomics for FST Gene

Regulatory Elements for FST Gene

Enhancers for FST Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FST on UCSC Golden Path with GeneCards custom track

Promoters for FST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FST on UCSC Golden Path with GeneCards custom track

Genomic Location for FST Gene

Chromosome:
5
Start:
53,480,341 bp from pter
End:
53,487,134 bp from pter
Size:
6,794 bases
Orientation:
Plus strand

Genomic View for FST Gene

Genes around FST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FST Gene

Proteins for FST Gene

  • Protein details for FST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19883-FST_HUMAN
    Recommended name:
    Follistatin
    Protein Accession:
    P19883
    Secondary Accessions:
    • B5BU94
    • Q9BTH0

    Protein attributes for FST Gene

    Size:
    344 amino acids
    Molecular mass:
    38007 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for FST Gene

    Alternative splice isoforms for FST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FST Gene

Proteomics data for FST Gene at MOPED

Post-translational modifications for FST Gene

  • Glycosylation at Asn 124 and Asn 288

Other Protein References for FST Gene

Antibody Products

No data available for DME Specific Peptides for FST Gene

Domains & Families for FST Gene

Protein Domains for FST Gene

Suggested Antigen Peptide Sequences for FST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19883

UniProtKB/Swiss-Prot:

FST_HUMAN :
  • Contains 3 follistatin-like domains.
Domain:
  • Contains 3 follistatin-like domains.
  • Contains 3 Kazal-like domains.
  • Contains 1 TB (TGF-beta binding) domain.
genes like me logo Genes that share domains with FST: view

No data available for Gene Families for FST Gene

Function for FST Gene

Molecular function for FST Gene

GENATLAS Biochemistry:
follistatin,an acitivin-binding protein,expressed in numerous tissues,including the ovary,pituitary,adrenal cortex and pancreas,neutralizing the biological acitivity of activin in vivo and in vitro,plausible candidate gene for polycystic ovary syndrome PCOS
UniProtKB/Swiss-Prot Function:
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

LifeMap Function Summary for FST Gene

During embryonic development, FST as signaling molecule is secreted from the following cells
genes like me logo Genes that share phenotypes with FST: view

Animal Models for FST Gene

MGI Knock Outs for FST:

Animal Model Products

miRNA for FST Gene

miRTarBase miRNAs that target FST

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FST Gene

Localization for FST Gene

Subcellular locations from UniProtKB/Swiss-Prot for FST Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FST Gene COMPARTMENTS Subcellular localization image for FST gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FST Gene

Pathways & Interactions for FST Gene

genes like me logo Genes that share pathways with FST: view

Pathways by source for FST Gene

1 Sino Biological pathway for FST Gene
1 GeneTex pathway for FST Gene
1 KEGG pathway for FST Gene
1 GeneGo (Thomson Reuters) pathway for FST Gene

Gene Ontology (GO) - Biological Process for FST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12702211
genes like me logo Genes that share ontologies with FST: view

No data available for SIGNOR curated interactions for FST Gene

Drugs & Compounds for FST Gene

(24) Drugs for FST Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-Myo-Inositol-Hexasulphate Experimental Pharma Target 0

(22) Additional Compounds for FST Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FST: view

Transcripts for FST Gene

Unigene Clusters for FST Gene

Follistatin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FST Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for FST Gene

GeneLoc Exon Structure for
FST
ECgene alternative splicing isoforms for
FST

Expression for FST Gene

mRNA expression in normal human tissues for FST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FST Gene

This gene is overexpressed in Liver (x7.6).

Protein differential expression in normal tissues from HIPED for FST Gene

This gene is overexpressed in Gallbladder (34.5) and Prostate (30.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FST Gene



SOURCE GeneReport for Unigene cluster for FST Gene Hs.9914

mRNA Expression by UniProt/SwissProt for FST Gene

P19883-FST_HUMAN
Tissue specificity: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.
genes like me logo Genes that share expression patterns with FST: view

Protein tissue co-expression partners for FST Gene

Orthologs for FST Gene

This gene was present in the common ancestor of animals.

Orthologs for FST Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FST 35
  • 92.34 (n)
  • 96.8 (a)
FST 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FST 35
  • 92.86 (n)
  • 97.62 (a)
FST 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fst 35
  • 91.16 (n)
  • 97.67 (a)
Fst 16
Fst 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FST 35
  • 99.42 (n)
  • 100 (a)
FST 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fst 35
  • 90.99 (n)
  • 97.67 (a)
oppossum
(Monodelphis domestica)
Mammalia FST 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FST 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves FST 35
  • 83.87 (n)
  • 89.5 (a)
FST 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FST 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fst 35
  • 77.18 (n)
  • 82.33 (a)
Str.10666 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1094 35
zebrafish
(Danio rerio)
Actinopterygii fst 35
fsta 35
  • 73.29 (n)
  • 78.79 (a)
fsta 36
  • 71 (a)
OneToMany
fstb 36
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006282 35
  • 48.28 (n)
  • 40.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fs 36
  • 16 (a)
OneToMany
Species with no ortholog for FST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FST Gene

ENSEMBL:
Gene Tree for FST (if available)
TreeFam:
Gene Tree for FST (if available)

Paralogs for FST Gene

Paralogs for FST Gene

(7) SIMAP similar genes for FST Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FST: view

Variants for FST Gene

Sequence variations from dbSNP and Humsavar for FST Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs11745088 - 53,483,680(+) GTAAA(C/G)AGCAG reference, missense
rs722910 -- 53,485,767(-) AAAAA(A/T)TTTTT intron-variant, utr-variant-3-prime
rs8434 -- 53,485,986(-) GTCTT(A/C)ATCTT reference, utr-variant-3-prime, stop-gained
rs15208 -- 53,486,013(-) AGAAG(A/G)TATAG reference, missense, utr-variant-3-prime
rs1044310 -- 53,484,260(+) GCAGA(G/T)CTATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FST Gene

Variant ID Type Subtype PubMed ID
nsv328038 CNV Loss 16902084

Variation tolerance for FST Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FST Gene

Disorders for FST Gene

MalaCards: The human disease database

(6) MalaCards diseases for FST Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
polycystic ovary syndrome
  • multicystic ovaries
adult spinal muscular atrophy
  • spinal muscular atrophy, adult form
obesity
  • obesity, association with
brachyolmia
  • brachyrachia
asphyxia neonatorum
  • asphyxia - birth
- elite association - COSMIC cancer census association via MalaCards
Search FST in MalaCards View complete list of genes associated with diseases

Relevant External Links for FST

Genetic Association Database (GAD)
FST
Human Genome Epidemiology (HuGE) Navigator
FST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FST
genes like me logo Genes that share disorders with FST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FST Gene

Publications for FST Gene

  1. Primary structure of the human follistatin precursor and its genomic organization. (PMID: 3380788) Shimasaki S. … Guillemin R. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 4 67
  2. Increased follistatin levels after oral contraceptive treatment in obese and non-obese women with polycystic ovary syndrome. (PMID: 20093255) Chen M.J. … Chen S.U. (Hum. Reprod. 2010) 3 23
  3. Role of follistatin in promoting adipogenesis in women. (PMID: 19470636) Flanagan J.N. … Dahlman I. (J. Clin. Endocrinol. Metab. 2009) 3 23
  4. Differential expression of follistatin and FLRG in human breast proliferative disorders. (PMID: 19740438) Bloise E. … Reis F.M. (BMC Cancer 2009) 3 23
  5. Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice. (PMID: 18245525) Ogino H. … Sone S. (Clin. Cancer Res. 2008) 3 23

Products for FST Gene

Sources for FST Gene

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