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Aliases for FST Gene

Aliases for FST Gene

  • Follistatin 2 3
  • FS 3 4 6
  • Activin-Binding Protein 3 4
  • Follistatin Isoform FST317 3

External Ids for FST Gene

Previous GeneCards Identifiers for FST Gene

  • GC05P052940
  • GC05P054206
  • GC05P052746
  • GC05P052792
  • GC05P052812
  • GC05P049748
  • GC05P052776

Summaries for FST Gene

Entrez Gene Summary for FST Gene

  • Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]

GeneCards Summary for FST Gene

FST (Follistatin) is a Protein Coding gene. Diseases associated with FST include polycystic ovary syndrome and endometriosis. Among its related pathways are Signaling by GPCR and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include signal transducer activity and activin binding. An important paralog of this gene is FSTL3.

UniProtKB/Swiss-Prot for FST Gene

  • Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)

Gene Wiki entry for FST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FST Gene

Genomics for FST Gene

Regulatory Elements for FST Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FST Gene

Start:
53,480,355 bp from pter
End:
53,487,134 bp from pter
Size:
6,780 bases
Orientation:
Plus strand

Genomic View for FST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FST Gene

Proteins for FST Gene

  • Protein details for FST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19883-FST_HUMAN
    Recommended name:
    Follistatin
    Protein Accession:
    P19883
    Secondary Accessions:
    • B5BU94
    • Q9BTH0

    Protein attributes for FST Gene

    Size:
    344 amino acids
    Molecular mass:
    38007 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for FST Gene

    Alternative splice isoforms for FST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FST Gene

Proteomics data for FST Gene at MOPED

Post-translational modifications for FST Gene

  • Glycosylation at Asn124 and Asn288

Other Protein References for FST Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FST Gene

Domains for FST Gene

Protein Domains for FST Gene

Suggested Antigen Peptide Sequences for FST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19883

UniProtKB/Swiss-Prot:

FST_HUMAN :
  • P19883
Domain:
  • Contains 3 follistatin-like domains.
  • Contains 3 Kazal-like domains.
  • Contains 1 TB (TGF-beta binding) domain.
genes like me logo Genes that share domains with FST: view

No data available for Gene Families for FST Gene

Function for FST Gene

Molecular function for FST Gene

GENATLAS Biochemistry: follistatin,an acitivin-binding protein,expressed in numerous tissues,including the ovary,pituitary,adrenal cortex and pancreas,neutralizing the biological acitivity of activin in vivo and in vitro,plausible candidate gene for polycystic ovary syndrome PCOS
UniProtKB/Swiss-Prot Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)

Gene Ontology (GO) - Molecular Function for FST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 12702211
GO:0005515 protein binding IPI 16198295
GO:0043395 heparan sulfate proteoglycan binding IEA --
GO:0048185 activin binding IPI 12697670
genes like me logo Genes that share ontologies with FST: view
genes like me logo Genes that share phenotypes with FST: view

Animal Models for FST Gene

MGI Knock Outs for FST:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FST

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FST Gene

Localization for FST Gene

Subcellular locations from UniProtKB/Swiss-Prot for FST Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FST Gene COMPARTMENTS Subcellular localization image for FST gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FST: view

Pathways for FST Gene

genes like me logo Genes that share pathways with FST: view

Pathways by source for FST Gene

1 KEGG pathway for FST Gene
1 GeneGo (Thomson Reuters) pathway for FST Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for FST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12702211
GO:0001501 skeletal system development IEA --
GO:0002244 hematopoietic progenitor cell differentiation IDA 15451575
GO:0007276 gamete generation IEA --
GO:0007389 pattern specification process IEA --
genes like me logo Genes that share ontologies with FST: view

Compounds for FST Gene

(1) Drugbank Compounds for FST Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
D-Myo-Inositol-Hexasulphate
target

(45) Novoseek inferred chemical compound relationships for FST Gene

Compound -log(P) Hits PubMed IDs
admp 61.9 1
gnrh 58.2 31
ribonucleic acid 54.3 5
progesterone 53.2 35
estradiol 44.1 18
genes like me logo Genes that share compounds with FST: view

Transcripts for FST Gene

Unigene Clusters for FST Gene

Follistatin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FST

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FST Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for FST Gene

GeneLoc Exon Structure for
FST
ECgene alternative splicing isoforms for
FST

Expression for FST Gene

mRNA expression in normal human tissues for FST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FST Gene

This gene is overexpressed in Liver (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FST Gene

SOURCE GeneReport for Unigene cluster for FST Gene Hs.9914

mRNA Expression by UniProt/SwissProt for FST Gene

P19883-FST_HUMAN
Tissue specificity: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.
genes like me logo Genes that share expressions with FST: view

In Situ Assay Products

Orthologs for FST Gene

This gene was present in the common ancestor of animals.

Orthologs for FST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FST 35
  • 99.42 (n)
  • 100 (a)
FST 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FST 35
  • 92.34 (n)
  • 96.8 (a)
FST 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FST 35
  • 92.86 (n)
  • 97.62 (a)
FST 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fst 35
  • 91.16 (n)
  • 97.67 (a)
Fst 16
Fst 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FST 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FST 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fst 35
  • 90.99 (n)
  • 97.67 (a)
chicken
(Gallus gallus)
Aves FST 35
  • 83.87 (n)
  • 89.5 (a)
FST 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FST 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1094 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fst 35
  • 77.18 (n)
  • 82.33 (a)
Str.10666 35
zebrafish
(Danio rerio)
Actinopterygii fst 35
fsta 35
  • 73.29 (n)
  • 78.79 (a)
fsta 36
  • 71 (a)
OneToMany
fstb 36
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006282 35
  • 48.28 (n)
  • 40.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fs 36
  • 16 (a)
OneToMany
Species with no ortholog for FST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FST Gene

ENSEMBL:
Gene Tree for FST (if available)
TreeFam:
Gene Tree for FST (if available)

Paralogs for FST Gene

Paralogs for FST Gene

Selected SIMAP similar genes for FST Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FST: view

Variants for FST Gene

Sequence variations from dbSNP and Humsavar for FST Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs8434 -- 53,485,986(-) GTCTT(A/C)ATCTT utr-variant-3-prime, reference, stop-gained, downstream-variant-500B
rs15208 -- 53,486,013(-) AGAAG(A/G)TATAG utr-variant-3-prime, missense, reference, downstream-variant-500B
rs722910 -- 53,485,767(-) AAAAA(A/T)TTTTT utr-variant-3-prime, intron-variant
rs1044310 -- 53,484,260(+) GCAGA(G/T)CTATT missense, reference
rs1062809 -- 53,484,261(+) CAGAT(A/C/G)TATTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FST Gene

Variant ID Type Subtype PubMed ID
nsv328038 CNV Loss 16902084

Relevant External Links for FST Gene

HapMap Linkage Disequilibrium report
FST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FST Gene

Disorders for FST Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for FST Gene including...

Search for FST Gene in MalaCards »

(1) University of Copenhagen DISEASES for FST Gene

(49) Novoseek inferred disease relationships for FST Gene

Disease -log(P) Hits PubMed IDs
polycystic ovary syndrome 55.7 17
infertility female 42.6 1
atresia 42.2 6
preeclampsia 27.4 16
polycystic ovaries 24.1 1

Relevant External Links for FST

Genetic Association Database (GAD)
FST
Human Genome Epidemiology (HuGE) Navigator
FST
genes like me logo Genes that share disorders with FST: view

No data available for UniProtKB/Swiss-Prot for FST Gene

Publications for FST Gene

  1. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. (PMID: 10411917) Urbanek M. … Dunaif A. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 23
  2. Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay. (PMID: 15472207) Schneyer A.L. … Sluss P.M. (J. Clin. Endocrinol. Metab. 2004) 3 4 23
  3. Polymorphism of the follistatin gene in polycystic ovary syndrome. (PMID: 17284512) Jones M.R. … Stuckey B.G. (Mol. Hum. Reprod. 2007) 3 23 48
  4. Primary structure of the human follistatin precursor and its genomic organization. (PMID: 3380788) Shimasaki S. … Guillemin R. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 4
  5. FLRG, member of the follistatin family, a new player in hematopoiesis. (PMID: 15451575) Maguer-Satta V. … Rimokh R. (Mol. Cell. Endocrinol. 2004) 3 23

Products for FST Gene

Sources for FST Gene

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