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Aliases for FSIP2 Gene

Aliases for FSIP2 Gene

  • Fibrous Sheath Interacting Protein 2 2 3 5

External Ids for FSIP2 Gene

Previous GeneCards Identifiers for FSIP2 Gene

  • GC02P186813
  • GC02P186435
  • GC02P186318
  • GC02U901571
  • GC02P186603
  • GC02P178463

Summaries for FSIP2 Gene

GeneCards Summary for FSIP2 Gene

FSIP2 (Fibrous Sheath Interacting Protein 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSIP2 Gene

Genomics for FSIP2 Gene

Regulatory Elements for FSIP2 Gene

Enhancers for FSIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FSIP2 on UCSC Golden Path with GeneCards custom track

Promoters for FSIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FSIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FSIP2 Gene

185,738,628 bp from pter
185,833,290 bp from pter
94,663 bases
Plus strand

Genomic View for FSIP2 Gene

Genes around FSIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSIP2 Gene

Proteins for FSIP2 Gene

  • Protein details for FSIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrous sheath-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q53TL3
    • Q53TN5
    • Q5HYH2
    • Q6ZTZ5
    • Q6ZU14
    • Q6ZU21

    Protein attributes for FSIP2 Gene

    6907 amino acids
    Molecular mass:
    780607 Da
    Quaternary structure:
    • May interact with AKAP4.
    • Sequence=AAY14863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AK126051; Type=Frameshift; Positions=6474; Evidence={ECO:0000305}; Sequence=CAI46017.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAI46017.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for FSIP2 Gene


neXtProt entry for FSIP2 Gene

Proteomics data for FSIP2 Gene at MOPED

Post-translational modifications for FSIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSIP2 Gene

No data available for DME Specific Peptides for FSIP2 Gene

Domains & Families for FSIP2 Gene

Protein Domains for FSIP2 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSIP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FSIP2 Gene

Function for FSIP2 Gene

Phenotypes for FSIP2 Gene

genes like me logo Genes that share phenotypes with FSIP2: view

Animal Model Products

CRISPR Products

miRNA for FSIP2 Gene

miRTarBase miRNAs that target FSIP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSIP2 Gene

Localization for FSIP2 Gene

Subcellular locations from

Jensen Localization Image for FSIP2 Gene COMPARTMENTS Subcellular localization image for FSIP2 gene
Compartment Confidence
mitochondrion 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FSIP2 Gene

Pathways & Interactions for FSIP2 Gene

SuperPathways for FSIP2 Gene

No Data Available

Interacting Proteins for FSIP2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000344403 for FSIP2 Gene via STRING

Gene Ontology (GO) - Biological Process for FSIP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for FSIP2 Gene

Drugs & Compounds for FSIP2 Gene

No Compound Related Data Available

Transcripts for FSIP2 Gene

Unigene Clusters for FSIP2 Gene

Fibrous sheath interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSIP2 Gene

No ASD Table

Relevant External Links for FSIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSIP2 Gene

mRNA expression in normal human tissues for FSIP2 Gene

mRNA differential expression in normal tissues according to GTEx for FSIP2 Gene

This gene is overexpressed in Testis (x17.2) and Colon - Transverse (x9.8).

Protein differential expression in normal tissues from HIPED for FSIP2 Gene

This gene is overexpressed in Breast (18.9), Plasma (9.8), and Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSIP2 Gene

SOURCE GeneReport for Unigene cluster for FSIP2 Gene Hs.98025

genes like me logo Genes that share expression patterns with FSIP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FSIP2 Gene

Orthologs for FSIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FSIP2 35
  • 81.57 (n)
  • 69.26 (a)
FSIP2 36
  • 69 (a)
(Canis familiaris)
Mammalia FSIP2 35
  • 81.02 (n)
  • 69.25 (a)
FSIP2 36
  • 68 (a)
(Mus musculus)
Mammalia Fsip2 35
  • 75.26 (n)
  • 61.64 (a)
Fsip2 16
Fsip2 36
  • 59 (a)
(Pan troglodytes)
Mammalia FSIP2 35
  • 99.36 (n)
  • 98.67 (a)
FSIP2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fsip2 35
  • 73.67 (n)
  • 60.59 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
-- 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia FSIP2 36
  • 60 (a)
(Anolis carolinensis)
Reptilia FSIP2 36
  • 26 (a)
Species with no ortholog for FSIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FSIP2 Gene

Gene Tree for FSIP2 (if available)
Gene Tree for FSIP2 (if available)

Paralogs for FSIP2 Gene Pseudogenes for FSIP2 Gene

genes like me logo Genes that share paralogs with FSIP2: view

No data available for Paralogs for FSIP2 Gene

Variants for FSIP2 Gene

Sequence variations from dbSNP and Humsavar for FSIP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs9808218 - 185,753,767(+) AAAAA(A/G)TGCAA reference, missense
VAR_075707 -
rs201794247 - 185,795,426(+) CTTTA(A/C)CATCT reference, missense
rs766394 -- 185,764,112(-) GACAC(A/T)GTTTT intron-variant
rs767042 -- 185,824,832(-) GGCAT(A/G)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSIP2 Gene

Variant ID Type Subtype PubMed ID
nsv875545 CNV Loss 21882294
esv2721236 CNV Deletion 23290073

Variation tolerance for FSIP2 Gene

Gene Damage Index Score: 15.57; 97.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FSIP2 Gene

Disorders for FSIP2 Gene

Relevant External Links for FSIP2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FSIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSIP2 Gene

Publications for FSIP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  5. A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. (PMID: 12606363) Brown P.R. … Eddy E.M. (Biol. Reprod. 2003) 3

Products for FSIP2 Gene

Sources for FSIP2 Gene