FSIP1 Gene
protein-coding GIFtS: 44
GCID: GC15M039892
|
|
fibrous sheath interacting protein 1
| |
Aliases
for FSIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibrous Sheath Interacting Protein 11 2 | | FLJ359891 | | Fibrous Sheath-Interacting Protein 12 |
Export aliases for FSIP1 gene to outside databasesPrevious GC identifers: GC15M037609 GC15M037679 GC15M016735 |
Summaries
for FSIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FSIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FSIP1 gene promoter:
AML1a LCR-F1 Tal-1beta HNF-3beta Evi-1 E47 AREB6 POU2F1 POU2F1a IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for FSIP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSIP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q14FSIP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M039892: view genomic region
(about GC identifiers)
Start:
|
39,892,232 bp from pter |
End:
|
40,075,039 bp from pter |
Size:
|
182,808 bases |
Orientation:
|
minus strand |
|
Proteins
for FSIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FSIP1_HUMAN, Q8NA03 (See
protein sequence)Recommended Name: Fibrous sheath-interacting protein 1 Size: 581 amino acids; 66121 Da
Secondary accessions: Q6X2C8 Q86Y89Explore the universe of human proteins at neXtProt for FSIP1: NX_Q8NA03
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NA03
FSIP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689810.3
ENSEMBL proteins: ENSP00000280236 ENSP00000454177
Human Recombinant Protein Products:
FSIP1 Antibody Products:
Assay Products for FSIP1: |
Protein
Domains /
Families
for FSIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FSIP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NA03ProtoNet protein and cluster: Q8NA03 UniProtKB/Swiss-Prot: FSIP1_HUMAN, Q8NA03Similarity: Belongs to the FSIP1 family |
Function
for FSIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSIP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FSIP1 (NM_152597) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FSIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSIP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSIP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
FSIP1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FSIP1:
|
Pathways & Interactions
for FSIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSIP1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for FSIP1 (Q8NA033 ENSP000002802364) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FSIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FSIP1
Search CenterWatch for drugs/clinical trials and news about FSIP1
|
Transcripts
for FSIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FSIP1 gene: NM_152597.4 Unigene Cluster for FSIP1: Fibrous sheath interacting protein 1 Hs.129598 [show with all ESTs]Unigene Representative Sequence: BC0451913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000350221(uc001zki.3) ENST00000559547 ENST00000559692
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSIP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FSIP1 (NM_152597) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FSIP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSIP1 |
Additional cDNA sequence: AK093308.1 AY260140.1 BC045191.2 4 DOTS entries: DT.100016090 DT.99993275 DT.121080994 DT.121081038 14 AceView cDNA sequences: AI792054 AX748045 AI820662 BX118373 AK093308 BX642685 NM_152597 BC045191 AY260140 BX642686 AA996091 BI561990 BI464818 AI813295
GeneLoc Exon Structure
|
Expression
for FSIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FSIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAATTTT
About this image
See FSIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FSIP1
SOURCE GeneReport for Unigene cluster: Hs.129598
SABiosciences Custom PCR Arrays for FSIP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSIP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FSIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSIP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSIP1 |
Orthologs
for FSIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FSIP1 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for FSIP1 (if available)
TreeFam Gene Tree for FSIP1 (if available) |
Paralogs
for FSIP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FSIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FSIP1 (39892232 - 40075039 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FSIP1
2 CNVs: 72236 4898
1 Indel: 72237 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSIP1 |
|
Disorders
/ Diseases
for FSIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FSIP1 for disorders About GeneDecksing
1  disease for FSIP1: About MalaCardsintellectual disability
Human Genome Epidemiology (HuGE) Navigator: FSIP1 (2 documents)
Export disorders for FSIP1 gene to outside databases
|
Publications
for FSIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FSIP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FSIP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Positive association between aspirin-intolerant asthm a and genetic polymorphisms of FSIP1: a case-case study. (PubMed id 20513247)1 Kim J.Y....Shin H.D. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. (PubMed id 12606363)1 Brown P.R....Eddy E.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for FSIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FSIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FSIP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FSIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FSIP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FSIP1 gene:
Search GeneIP for patents involving FSIP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FSIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FSIP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FSIP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSIP1 | | | OriGene Protein Over-expression Lysate for FSIP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FSIP1 | | OriGene 3'-UTR Clone for FSIP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSIP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSIP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FSIP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FSIP1 | | OriGene Custom Protein Services for FSIP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FSIP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSIP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSIP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSIP1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FSIP1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FSIP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSIP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for FSIP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSIP1 |
|
|
|
|
