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Aliases for FSIP1 Gene

Aliases for FSIP1 Gene

  • Fibrous Sheath Interacting Protein 1 2 3 5
  • Fibrous Sheath-Interacting Protein 1 3
  • HSD10 3

External Ids for FSIP1 Gene

Previous GeneCards Identifiers for FSIP1 Gene

  • GC15M037609
  • GC15M037679
  • GC15M039892
  • GC15M016735

Summaries for FSIP1 Gene

GeneCards Summary for FSIP1 Gene

FSIP1 (Fibrous Sheath Interacting Protein 1) is a Protein Coding gene. Diseases associated with FSIP1 include Syndromic X-Linked Intellectual Disability Type 10 and Chromosome 3Q29 Duplication Syndrome.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSIP1 Gene

Genomics for FSIP1 Gene

Regulatory Elements for FSIP1 Gene

Enhancers for FSIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G039620 2 FANTOM5 Ensembl ENCODE dbSUPER 15.5 +156.5 156454 10.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 FSIP1 THBS1 LOC105370785 ENSG00000259279
GH15G039884 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -104.7 -104680 6.9 ELF3 FOXA2 ARID4B RAD21 GATA2 SCRT2 RELB IKZF2 THAP11 PAF1 GPR176 EIF2AK4 LOC100505534 ENSG00000200305 FSIP1 GC15P039911 LOC105370786
GH15G039640 1.6 Ensembl ENCODE dbSUPER 10.3 +140.7 140731 2.7 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS FSIP1 LOC105370785 LOC105370941
GH15G039906 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -125.4 -125379 2.6 SOX13 PAF1 JUN BHLHE40 HLF MAX CEBPB USF2 ZNF121 RAD51 EIF2AK4 FSIP1 GPR176 GC15P039911 LOC105370786
GH15G039153 1.4 Ensembl ENCODE dbSUPER 8.9 +627.4 627393 3.7 ELF3 FOXA2 BMI1 THRB RAD21 RARA FOS CREM NR2F2 NFIL3 THBS1 FSIP1 LOC105370780 LOC105370781
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FSIP1 on UCSC Golden Path with GeneCards custom track

Promoters for FSIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FSIP1 Gene

39,599,529 bp from pter
39,782,838 bp from pter
183,310 bases
Minus strand

Genomic View for FSIP1 Gene

Genes around FSIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSIP1 Gene

Proteins for FSIP1 Gene

  • Protein details for FSIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrous sheath-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6X2C8
    • Q86Y89

    Protein attributes for FSIP1 Gene

    581 amino acids
    Molecular mass:
    66121 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FSIP1 Gene

Post-translational modifications for FSIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FSIP1 Gene

Domains & Families for FSIP1 Gene

Protein Domains for FSIP1 Gene


Suggested Antigen Peptide Sequences for FSIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FSIP1 family.
  • Belongs to the FSIP1 family.
genes like me logo Genes that share domains with FSIP1: view

No data available for Gene Families for FSIP1 Gene

Function for FSIP1 Gene

genes like me logo Genes that share phenotypes with FSIP1: view

Animal Model Products

CRISPR Products

miRNA for FSIP1 Gene

miRTarBase miRNAs that target FSIP1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSIP1 Gene

Localization for FSIP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSIP1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FSIP1 Gene

Pathways & Interactions for FSIP1 Gene

SuperPathways for FSIP1 Gene

No Data Available

Interacting Proteins for FSIP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8NA03-FSIP1_HUMAN ENSP00000280236 for FSIP1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FSIP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FSIP1 Gene

Drugs & Compounds for FSIP1 Gene

(1) Drugs for FSIP1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1152
genes like me logo Genes that share compounds with FSIP1: view

Transcripts for FSIP1 Gene

mRNA/cDNA for FSIP1 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSIP1 Gene

Fibrous sheath interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSIP1 Gene

No ASD Table

Relevant External Links for FSIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSIP1 Gene

mRNA differential expression in normal tissues according to GTEx for FSIP1 Gene

This gene is overexpressed in Testis (x10.1).

Protein differential expression in normal tissues from HIPED for FSIP1 Gene

This gene is overexpressed in Brain (42.1) and Testis (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSIP1 Gene

Protein tissue co-expression partners for FSIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FSIP1 Gene:


SOURCE GeneReport for Unigene cluster for FSIP1 Gene:

genes like me logo Genes that share expression patterns with FSIP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSIP1 Gene

Orthologs for FSIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FSIP1 34 35
  • 99.08 (n)
(Bos Taurus)
Mammalia FSIP1 34 35
  • 84.02 (n)
(Canis familiaris)
Mammalia FSIP1 34 35
  • 83.92 (n)
(Mus musculus)
Mammalia Fsip1 34 16 35
  • 74.87 (n)
(Rattus norvegicus)
Mammalia Fsip1 34
  • 72.67 (n)
(Ornithorhynchus anatinus)
Mammalia FSIP1 35
  • 47 (a)
(Monodelphis domestica)
Mammalia FSIP1 35
  • 38 (a)
(Gallus gallus)
Aves FSIP1 34 35
  • 57.39 (n)
(Anolis carolinensis)
Reptilia FSIP1 35
  • 33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fsip1 34
  • 50.97 (n)
(Danio rerio)
Actinopterygii fsip1 34
  • 47.71 (n)
Species where no ortholog for FSIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSIP1 Gene

Gene Tree for FSIP1 (if available)
Gene Tree for FSIP1 (if available)

Paralogs for FSIP1 Gene

No data available for Paralogs for FSIP1 Gene

Variants for FSIP1 Gene

Sequence variations from dbSNP and Humsavar for FSIP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000012797 -- 39,688,493(+) GGTAT(C/T)CGAGT intron-variant
rs1000017427 -- 39,639,431(+) CAAAC(-/A)ATTTT intron-variant
rs1000020386 -- 39,669,000(+) TTATG(A/C)GTATT intron-variant
rs1000046771 -- 39,619,862(+) TAGAA(A/G)AAAAA intron-variant
rs1000066470 -- 39,688,780(+) AGCAC(C/T)CAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSIP1 Gene

Variant ID Type Subtype PubMed ID
esv1286390 CNV insertion 17803354
esv24232 CNV loss 19812545
esv2749591 CNV deletion 23290073
esv3569465 CNV gain 25503493
esv3636219 CNV loss 21293372
nsv1048628 CNV gain 25217958
nsv1127427 CNV deletion 24896259
nsv1502 CNV deletion 18451855
nsv832977 CNV gain 17160897
nsv832978 CNV gain 17160897
nsv832979 CNV gain+loss 17160897

Variation tolerance for FSIP1 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.51; 92.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSIP1 Gene

Disorders for FSIP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FSIP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
syndromic x-linked intellectual disability type 10
  • x-linked intellectual disability-choreoathetosis-abnormal behavior syndrome
chromosome 3q29 duplication syndrome
  • 3q29 microduplication
chromosome 3q29 microduplication syndrome
  • chromosome 3q29 duplication syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FSIP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FSIP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FSIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FSIP1 Gene

Publications for FSIP1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. (PMID: 20513247) Kim J.Y. … Shin H.D. (BMC Pulm Med 2010) 3 46 64
  4. Expression and clinicopathological significance of FSIP1 in breast cancer. (PMID: 25826084) Zhang H. … Liu C. (Oncotarget 2015) 3 64
  5. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. (PMID: 24968937) Maldarelli F. … Hughes S.H. (Science 2014) 3 64

Products for FSIP1 Gene

Sources for FSIP1 Gene

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