Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FSHB Gene

protein-coding   GIFtS: 63
GCID: GC11P030210

follicle stimulating hormone, beta polypeptide

 Explore 38 diseases affiliated with
FSHB via our new
 Human Malady Compendium 
Biological research products
for FSHB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Follicle Stimulating Hormone, Beta Polypeptide1 2     FSH-Beta1
Follicle-Stimulating Hormone Beta Subunit2 3     Follitropin Subunit Beta2
Follitropin Beta Chain2 3     Follitropin, Beta Chain2
FSH-B2 3     

External Ids:    HGNC: 39641   Entrez Gene: 24882   Ensembl: ENSG000001318087   OMIM: 1365305   UniProtKB: P012253   

Export aliases for FSHB gene to outside databases

Previous GC identifers: GC11P031850 GC11P031028 GC11P030292 GC11P030217 GC11P029945


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FSHB:
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic
gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a
hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with
luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in
two transcript variants encoding the same protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
Function: Stimulates development of follicle and spermatogenesis in the reproductive organs

Gene Wiki entry for FSHB


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FSHB gene promoter:
         Sox5   Nkx2-5   CREB   MEF-2A   SRY   deltaCREB   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSHB promoter sequence
   Search SABiosciences Chromatin IP Primers for FSHB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p13

FSHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSHB gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P030210:  view genomic region     (about GC identifiers)

Start:
30,252,563 bp from pter      End:
30,256,824 bp from pter
Size:
4,262 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225 (See protein sequence)
Recommended Name: Follitropin subunit beta precursor  
Size: 129 amino acids; 14700 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for FSHB:
1FL7 (3D)        1XWD (3D)        4AY9 (3D)    
Secondary accessions: A2TF08 A5JVV3 Q14D61

Explore the universe of human proteins at neXtProt for FSHB: NX_P01225

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01225

  • FSHB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000501.1  NP_001018090.1  

    ENSEMBL proteins: 
     ENSP00000254122   ENSP00000416606   ENSP00000433424  
    Reactome Protein details: P01225
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FSHB (FSH alpha/beta)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): FSHB
    OriGene Protein Over-expression Lysate (see all 2): FSHB
    OriGene Custom Protein Services for FSHB 
    GenScript Custom Purified and Recombinant Proteins Services for FSHB
    Novus Biologicals FSHB Proteins
    Novus Biologicals FSHB Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for FSHB
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm IDA14602737


    FSHB for ontologies           About GeneDecksing



    FSHB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FSHB
    R&D Systems Antibodies for FSHB (FSH beta)
    OriGene Antibodies (see all 17): FSHB
    OriGene Custom Antibody Services for FSHB 
    GenScript Custom Superior Antibodies Services for FSHB
    Novus Biologicals FSHB Antibodies
    Abcam antibodies for FSHB 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for FSHB

    Assay Products for FSHB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FSHB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FSHB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01225

    ProtoNet protein and cluster: P01225

    3 Blocks protein families:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
    Function: Stimulates development of follicle and spermatogenesis in the reproductive organs

         Genatlas biochemistry entry for FSHB:
    follicle stimulating hormone,beta polypeptide

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FSHB
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FSHB:
    hsa-miR-140-5p hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidFSHB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FSHB (see all 7)
    OriGene shRNA RFP: FSHB
    OriGene siRNA: FSHB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSHB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FSHB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSHB (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSHB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FSHB (NM_001018080)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSHB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FSHB
    Search LifeMap BioReagents cell lines for FSHB

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSHB

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS8220432
    GO:0005515protein binding IPI15662415
    GO:0016913follicle-stimulating hormone activity NAS--
    GO:0046982protein heterodimerization activity NAS--


    FSHB for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fshbtm1Zuk for FSHB
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fshb):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    FSHB for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycoprotein hormones
    Glycoprotein hormones1.00
    Hormone ligand-binding receptors0.33
    Peptide hormone biosynthesis0.71
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    Neuroactive ligand-receptor interaction0.38
    GPCR ligand binding0.75
    3Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    4Transcription_CREM signaling in testis
    Transcription_CREM signaling in testis1.00
    Transcription CREM signaling in testis0.96
    5PKA activation in glucagon signalling
    Development_Role of Activin A in cell differentiation and proliferation0.33
    Development Role of Activin A in cell differentiation and proliferation0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for FSHB
        Development Role of Activin A in cell differentiation and proliferation
    Selected targets of GCR-alpha
    Transcription CREM signaling in testis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FSHB
        GnRH Signaling

    2 GeneGo (Thomson Reuters) Pathways for FSHB
        Development Role of Activin A in cell differentiation and proliferation
    Transcription CREM signaling in testis

    1 BioSystems Pathway for FSHB 
        FSH signaling pathway

    5/11        Reactome Pathways for FSHB (see all 11)
        GPCR downstream signaling
    Peptide hormone biosynthesis
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    2         Kegg Pathways  (Kegg details for FSHB):
        Neuroactive ligand-receptor interaction
    GnRH signaling pathway


    FSHB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FSHB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/12 Interacting proteins for FSHB (P012251, 3 ENSP000002541224) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGBP012333, ENSP000003499544I2D: score=1 STRING: ENSP00000349954
    CGB5P012333I2D: score=1 
    CGB7P012333I2D: score=1 
    CGB8P012333I2D: score=1 
    CGAP012151, 3, ENSP000003585954EBI-1030645,EBI-718913 I2D: score=4 STRING: ENSP00000358595
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development NAS--
    GO:0006701progesterone biosynthetic process TAS14557487
    GO:0007165signal transduction TAS8220432
    GO:0007179transforming growth factor beta receptor signaling pathway IEP14557487
    GO:0007283spermatogenesis NAS--


    FSHB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FSHB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FSHB
    UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
    Pharmaceutical: Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment
    of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation
    treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of
    hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis

    10/21 Novoseek chemical compound relationships for FSHB gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 79.8 74 1730329 (4), 20008557 (4), 19787048 (3), 16141398 (3) (see all 31)
    ptx1 75.3 1 10859489 (1)
    organon 70.3 6 10632423 (1), 11406034 (1), 14520188 (1), 9457926 (1) (see all 6)
    ganirelix 69.7 9 12620447 (4), 14688163 (1), 11163814 (1)
    ribonucleic acid 59.1 2 1727723 (1), 8299592 (1)
    estradiol 55.2 4 16807382 (1), 15240592 (1)
    clomiphene citrate 43.4 1 9935125 (1)
    buserelin 35.2 2 10632423 (1), 11334903 (1)
    progesterone 34 9 1727723 (3), 7867558 (2)
    testosterone 33.7 9 1370794 (2), 11399484 (2), 7544877 (1), 1794614 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about FSHB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FSHB gene (2 alternative transcripts): 
    NM_000510.2  NM_001018080.1  

    Unigene Cluster for FSHB:

    Follicle stimulating hormone, beta polypeptide
    Hs.36975  [show with all ESTs]
    Unigene Representative Sequence: NM_000510
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254122 ENST00000417547(uc001msl.3 uc001msm.3 uc001msn.3)
    ENST00000533718

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FSHB
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FSHB:
    hsa-miR-140-5p hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidFSHB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FSHB (see all 7)
    OriGene shRNA RFP: FSHB
    OriGene siRNA: FSHB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSHB
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSHB (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSHB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FSHB (NM_001018080)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSHB 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSHB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FSHB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSHB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSHB

    Additional cDNA sequence: 

    BC113488.1 BC113490.1 EF585489.1 

    2 DOTS entries:

    DT.120746996  DT.306280 

    11 AceView cDNA sequences:

    CD105280 CD107377 NM_000510 CD108062 AV754501 AV754057 AV755146 AV754300 
    CD556357 BF949342 BQ340349 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FSHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGATTCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FSHB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FSHB

    SOURCE GeneReport for Unigene cluster: Hs.36975
        SABiosciences Custom PCR Arrays for FSHB
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSHB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FSHB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSHB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSHB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSHB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FSHB gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FSHB1 follicle stimulating hormone, beta polypeptide 72.58(n)
    69.35(a)
      374108  NM_204257.1  NP_989588.1 
    lizard
    (Anolis carolinensis)
    Reptilia FSHB6
    --
    62(a)
    1 ↔ 1
    1(59441433-59442657)
    zebrafish
    (Danio rerio)
    Actinopterygii fshb1 follicle stimulating hormone, beta polypeptide 55.09(n)
    47.37(a)
      402919  NM_205624.1  NP_991187.1 


    ENSEMBL Gene Tree for FSHB (if available)
    TreeFam Gene Tree for FSHB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FSHB gene
    TSHB2  CGB22  LHB2  CGB82  ENSG000002673352  CGB2  CGB52  CGB72  
    CGB12  
    9 SIMAP similar genes for FSHB using alignment to 3 protein entries:     FSHB_HUMAN (see all proteins):
    TSHB    CGB1    CGB2    CGB7    CGB8    CGB
    CGB5    GPHB5    LHB

    FSHB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FSHB
    PGOHUM00000242629


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/110 NCBI SNPs in FSHB are shown (see all 110    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs50307761,2
    Cpathogenic71284185(+) AAACAT/GGTACC 4 /G /C mis12Minor allele frequency- G:0.00NA 4
    rs791243131,2
    --29945252(+) TTAGTT/CGCACA 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs6130581,2
    C,F,H,--29945639(-) GCCACC/AATTCC 2 -- int117Minor allele frequency- A:0.11NS EA NA WA 2182
    rs343941851,2
    F--29945902(+) ATTCTA/TATCTT 2 -- int16Minor allele frequency- T:0.00EU WA EA 442
    rs342790611,2
    C,--29946773(+) AAAACA/GTAGAC 2 -- int13Minor allele frequency- G:0.01EU WA EA 192
    rs781308641,2
    --29947075(+) TGGCAA/GCTTTT 2 -- int10--------
    rs771933891,2
    --29947089(+) ATGAAC/TGATAC 2 -- int10--------
    rs745668311,2
    --29947167(+) TATACA/GTTTGG 2 -- int11Minor allele frequency- G:0.01NA 120
    rs789464831,2
    C,F,--29949030(+) TAATTT/GGTCTA 2 -- ut311Minor allele frequency- G:0.03NA 120
    rs754648951,2
    --29949091(+) GGGACG/AAGGGG 2 -- ut311Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for FSHB (30252563 - 30256824 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FSHB: --
    Human Gene Mutation Database (HGMD): FSHB

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSHB
    DNA2.0 Custom Variant and Variant Library Synthesis for FSHB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FSHB for disorders           About GeneDecksing

    OMIM gene information: 136530   
    OMIM disorders: 229070  
    UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
  • Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070].
  • Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and
    hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men

    20/38 diseases for FSHB (see all 38):    About MalaCards
    follicle-stimulating hormone deficiency    follicle-stimulating hormone deficiency, isolated    conjunctivitis    ovarian hyperstimulation syndrome
    polycystic ovary syndrome    precocious puberty    thyroiditis    pituitary adenoma
    delayed puberty    premature ovarian failure    virilization    wagr syndrome
    amenorrhea    pituitary tumor    male infertility    anovulation
    galactosemia    transitional cell carcinoma    aniridia    hypogonadism

    2 diseases from the University of Copenhagen DISEASES database for FSHB:
    Aniridia     WAGR syndrome

    10/15 Novoseek disease relationships for FSHB gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian hyperstimulation syndrome 71.8 1 18230195 (1)
    gonadotropins increased 66.2 1 16959402 (1)
    pituitary adenoma nonfunctioning 62.8 1 1375599 (1)
    infertility 62.3 4 11299519 (2), 16730882 (1), 17227474 (1)
    puberty delayed 61.7 3 16730882 (1), 9271483 (1), 20067895 (1)
    pituitary adenoma 60.4 4 8881451 (3), 1902844 (1)
    primary amenorrhea 60.4 1 19966036 (1)
    pituitary tumors 56 2 1902844 (1), 1375599 (1)
    azoospermia 55.3 4 16730882 (1), 12568849 (1), 12161499 (1), 10864828 (1)
    hypogonadism 51.4 4 19966036 (1), 9271483 (1), 12568849 (1), 20067895 (1)

    Genatlas disease: FSHB
    delayed puberty,primary amenorrhea,infertility (FSH deficiency,isolated),hypogonadism in man

    Genetic Association Database (GAD): FSHB
    Human Genome Epidemiology (HuGE) Navigator: FSHB (9 documents)

    Export disorders for FSHB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FSHB gene, integrated from 9 sources (see all 208):
    (articles sorted by number of sources associating them with FSHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A reevaluation of the amino acid sequence of human follitropin beta- subunit. (PubMed id 3151250)1, 2, 3 Shome B.... Ward D.N. (1988)
    2. DNA sequence and regional assignment of the human follicle- stimulating hormone beta-subunit gene to the short arm of human chromosome 11. (PubMed id 2885163)1, 2, 3 Watkins P.C.... Shows T.B. (1987)
    3. Association of AccI polymorphism in the follicle-stimulating hormone beta gene with polycystic ovary syndrome. (PubMed id 11119757)1, 4, 9 Tong Y....Ng S.C. (2000)
    4. Delayed puberty and hypogonadism caused by mutations in the follicle- stimulating hormone beta-subunit gene. (PubMed id 9271483)1, 2, 9 Layman L.C....Jameson J.L. (1997)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
    6. Structure of human follicle-stimulating hormone in complex with its receptor. (PubMed id 15662415)1, 2 Fan Q.R. and Hendrickson W.A. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Three-dimensional structure of human follicle-stimulating hormone. (PubMed id 11222739)1, 2 Fox K.M.... Van Roey P. (2001)
    9. Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain. (PubMed id 11501762)1, 2 Amoresano A.... Pucci P. (2001)
    10. Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)1, 2 Cargill M....Lander E.S. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2488 HGNC: 3964 AceView: FSHB Ensembl:ENSG00000131808 euGenes: HUgn2488
    ECgene: FSHB Kegg: 2488 H-InvDB: FSHB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FSHB Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FSHB
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FSHB
    Wikipedia http://en.wikipedia.org/wiki/Follicle_stimulating_hormone

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FSHB gene:
    Search GeneIP for patents involving FSHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of FSHB
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FSHB (FSH beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for FSHB (FSH alpha/beta)  
     OriGene Antibodies for FSHB   OriGene shRNA RFP for FSHB  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FSHB   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSHB  
     OriGene Protein Over-expression Lysate for FSHB   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FSHB   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSHB   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSHB  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for FSHB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FSHB   OriGene Custom Protein Services for FSHB  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FSHB
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSHB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSHB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSHB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSHB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSHB
     GenScript Custom Purified and Recombinant Proteins Services for FSHB GenScript cDNA clones with any tag delivered in your preferred vector for FSHB
     GenScript Custom Assay Services for FSHB GenScript Custom Superior Antibodies Services for FSHB
     GenScript Custom overexpressing Cell Line Services for FSHB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FSHB promoter
     Search Chromatin IP Primers for FSHB
     RT2 qPCR Primer Assay in human, mouse, rat FSHB
     GNC Network for FSHB
     SABiosciences PCR Arrays including human, mouse, rat FSHB
     Search Tocris compounds for FSHB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FSHB antibodies
     FSHB proteins
     FSHB lysates
     Antibodies for FSHB
     See all of Abcam's Antibodies, Kits and Proteins for FSHB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FSHB




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for FSHB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSHB
     SwitchGear 3'UTR luciferase reporter plasmids for FSHB
     SwitchGear Promoter luciferase reporter plasmids for FSHB
     ThermoFisher Antibodies for FSHB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSHB
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FSHB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4