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FSHB Gene

protein-coding   GIFtS: 64
GCID: GC11P030210

Follicle Stimulating Hormone, Beta Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Follicle Stimulating Hormone, Beta Polypeptide1 2     Beta Chain1
Follicle-Stimulating Hormone Beta Subunit1 2 3     follitropin1
Follitropin Beta Chain2 3     Follitropin Subunit Beta2
FSH-B2 3     Follitropin, Beta Chain2
FSH-beta2 3     

External Ids:    HGNC: 39641   Entrez Gene: 24882   Ensembl: ENSG000001318087   OMIM: 1365305   UniProtKB: P012253   

Export aliases for FSHB gene to outside databases

Previous GC identifers: GC11P031850 GC11P031028 GC11P030292 GC11P030217 GC11P029945


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FSHB Gene:
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic
gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit
and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In
conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative
splicing results in two transcript variants encoding the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for FSHB Gene:
FSHB (follicle stimulating hormone, beta polypeptide) is a protein-coding gene. Diseases associated with FSHB include follicle-stimulating hormone deficiency, isolated, and pandas. GO annotations related to this gene include follicle-stimulating hormone activity and protein heterodimerization activity. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
Function: Stimulates development of follicle and spermatogenesis in the reproductive organs

Gene Wiki entry for FSHB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the FSHB gene promoter:
         Sox5   Nkx2-5   CREB   MEF-2A   SRY   deltaCREB   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSHB promoter sequence
   Search Chromatin IP Primers for FSHB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FSHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p13

FSHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSHB gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P030210:  view genomic region     (about GC identifiers)

Start:
30,252,563 bp from pter      End:
30,256,824 bp from pter
Size:
4,262 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225 (See protein sequence)
Recommended Name: Follitropin subunit beta precursor  
Size: 129 amino acids; 14700 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
3 PDB 3D structures from and Proteopedia for FSHB:
1FL7 (3D)        1XWD (3D)        4AY9 (3D)    
Secondary accessions: A2TF08 A5JVV3 Q14D61

Explore the universe of human proteins at neXtProt for FSHB: NX_P01225

Explore proteomics data for FSHB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn25, Asn42
  • Modification sites at PhosphoSitePlus

  • See FSHB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000501.1  NP_001018090.1  

    ENSEMBL proteins: 
     ENSP00000254122   ENSP00000416606   ENSP00000433424  
    Reactome Protein details: P01225

    FSHB Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    FSHB Antibody Products:

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    Abcam antibodies for FSHB (P01215, P01225)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01225

    ProtoNet protein and cluster: P01225

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    FSHB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSHB_HUMAN, P01225
    Function: Stimulates development of follicle and spermatogenesis in the reproductive organs

         Genatlas biochemistry entry for FSHB:
    follicle stimulating hormone,beta polypeptide

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI11222739
    GO:0016913follicle-stimulating hormone activity ----
    GO:0046982protein heterodimerization activity ----
         
    FSHB for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fshb):
     endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    FSHB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fshbtm1Zuk for FSHB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FSHB
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FSHB

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FSHB:
    hsa-miR-140-5p hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidFSHB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FSHB

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    Sino Biological Human cDNA Clone for FSHB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSHB

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSHB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FSHB_HUMAN, P01225: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm IDA14602737

    FSHB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FSHB About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    4Integrin Pathway
    GnRH Signaling0.56
    5Development Endothelin 1 EDNRA signaling
    GnRH signaling pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FSHB
        GnRH Signaling

    2 GeneGo (Thomson Reuters) Pathways for FSHB
        Development Role of Activin A in cell differentiation and proliferation
    Transcription CREM signaling in testis

    1 BioSystems Pathway for FSHB
        FSH signaling pathway


    3 Reactome Pathways for FSHB
        Hormone ligand-binding receptors
    Glycoprotein hormones
    G alpha (s) signalling events


    3 Kegg Pathways  (Kegg details for FSHB):
        Neuroactive ligand-receptor interaction
    GnRH signaling pathway
    Ovarian steroidogenesis


    FSHB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FSHB
    Interactions:

        GeneGlobe Interaction Network for FSHB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FSHB (P012251, 3 ENSP000002541224) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGBP012333, ENSP000003499544I2D: score=1 STRING: ENSP00000349954
    CGB5P012333I2D: score=1 
    CGB7P012333I2D: score=1 
    CGB8P012333I2D: score=1 
    CGAP012151, 3, ENSP000003585954EBI-1030645,EBI-718913 I2D: score=4 STRING: ENSP00000358595
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development ----
    GO:0006701progesterone biosynthetic process TAS14557487
    GO:0007165signal transduction TAS8220432
    GO:0007179transforming growth factor beta receptor signaling pathway IEP14557487
    GO:0007283spermatogenesis ----

    FSHB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FSHB

    UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
    Pharmaceutical: Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the
    treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in
    superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in
    the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis

    Selected Novoseek inferred chemical compound relationships for FSHB gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 79.8 74 1730329 (4), 20008557 (4), 19787048 (3), 16141398 (3) (see all 31)
    ptx1 75.3 1 10859489 (1)
    organon 70.3 6 10632423 (1), 11406034 (1), 14520188 (1), 9457926 (1) (see all 6)
    ganirelix 69.7 9 12620447 (4), 14688163 (1), 11163814 (1)
    ribonucleic acid 59.1 2 1727723 (1), 8299592 (1)
    estradiol 55.2 4 16807382 (1), 15240592 (1)
    clomiphene citrate 43.4 1 9935125 (1)
    buserelin 35.2 2 10632423 (1), 11334903 (1)
    progesterone 34 9 1727723 (3), 7867558 (2)
    testosterone 33.7 9 1370794 (2), 11399484 (2), 7544877 (1), 1794614 (1) (see all 5)



    FSHB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FSHB gene (2 alternative transcripts): 
    NM_000510.2  NM_001018080.1  

    Unigene Cluster for FSHB:

    Follicle stimulating hormone, beta polypeptide
    Hs.36975  [show with all ESTs]
    Unigene Representative Sequence: NM_000510
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254122 ENST00000417547(uc001msl.3 uc001msm.3 uc001msn.3)
    ENST00000533718
    miRNA
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    hsa-miR-140-5p hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidFSHB 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FSHB
      QuantiFast Probe-based Assays in human, mouse, rat FSHB

    Additional mRNA sequence: 

    BC113488.1 BC113490.1 EF585489.1 

    2 DOTS entries:

    DT.120746996  DT.306280 

    11 AceView cDNA sequences:

    CD107377 CD105280 CD108062 NM_000510 AV754501 AV754057 AV755146 AV754300 
    CD556357 BF949342 BQ340349 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FSHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTCCTT
    FSHB Expression
    About this image

    FSHB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FSHB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.36975
        Custom PCR Arrays for FSHB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSHB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FSHB gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fshb1 , 5 follicle stimulating hormone beta1, 5 85.01(n)1
    86.05(a)1
      2 (56.02 cM)5
    143081  NM_008045.21  NP_032071.11 
     1070561405 
    chicken
    (Gallus gallus)
    Aves FSHB1 follicle stimulating hormone, beta polypeptide 72.22(n)
    68.25(a)
      374108  NM_204257.1  NP_989588.1 
    lizard
    (Anolis carolinensis)
    Reptilia FSHB6
    follicle stimulating hormone, beta polypeptide
    62(a)
    1 ↔ 1
    1(59441433-59442657)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fshb1 follicle stimulating hormone, beta polypeptide 63.82(n)
    55.81(a)
      100495812  XM_002937680.2  XP_002937726.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fshb1 follicle stimulating hormone, beta polypeptide 55.43(n)
    47.83(a)
      402919  NM_205624.1  NP_991187.1 


    ENSEMBL Gene Tree for FSHB (if available)
    TreeFam Gene Tree for FSHB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for FSHB gene
    TSHB2  CGB22  LHB2  CGB82  ENSG000002673352  CGB52  CGB2  CGB72  
    CGB12  
    9 SIMAP similar genes for FSHB using alignment to 3 protein entries:     FSHB_HUMAN (see all proteins):
    TSHB    CGB1    CGB2    CGB7    CGB8    CGB
    CGB5    GPHB5    LHB

    FSHB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FSHB
    PGOHUM00000242629


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FSHB (see all 141)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs50307761,2,,4
    CIsolated follicle-stimulating hormone deficiency (IFSHD)4 pathogenic130182587(+) AAACAT/GGTACC 4 /G /C mis12Minor allele frequency- G:0.00NA 4
    rs6546691,2
    C,F,A,H--30177993(-) CCACCA/GTGCCT 2 -- us2k16Minor allele frequency- G:0.07NA MN CSA 194
    rs1822377381,2
    --30177994(+) GGCATA/GGTGGC 2 -- us2k10--------
    rs1872670031,2
    C--30178013(+) GTAGTC/GTCAGG 2 -- us2k10--------
    rs1882222421,2
    C--30178176(+) TACCCA/GACATC 2 -- us2k10--------
    rs1472064751,2
    C--30178284(+) TTAAAC/TACATA 2 -- us2k10--------
    rs1405135261,2
    --30178287(+) AACACA/TTACCA 2 -- us2k10--------
    rs1807063931,2
    --30178288(+) ACACAC/TACCAA 2 -- us2k10--------
    rs1170142491,2
    C,F--30178293(+) TACCAA/GTCAGG 2 -- us2k11Minor allele frequency- G:0.03EA 120
    rs342244141,2
    C,F--30178466(+) GCTTTT/GGGGAC 2 -- us2k17Minor allele frequency- G:0.15NA WA CSA EA 365

    HapMap Linkage Disequilibrium report for FSHB (30252563 - 30256824 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FSHB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv437712CNV Loss16327808

    Human Gene Mutation Database (HGMD): FSHB
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FSHB
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136530   
    OMIM disorders: 229070  
    UniProtKB/Swiss-Prot: FSHB_HUMAN, P01225
  • Isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070]: Selective follicle-stimulating
    hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo
    or azoospermia with normal testosterone levels in normally virilised men. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for FSHB (see all 36):    
    About MalaCards
    follicle-stimulating hormone deficiency, isolated    pandas    conjunctivitis    hermaphroditism
    wagr syndrome    ovarian hyperstimulation syndrome    central precocious puberty    amenorrhea
    nephroblastoma    aniridia    galactosemia    anovulation
    precocious puberty    adrenocortical carcinoma    hypogonadotropism    polycystic ovary syndrome
    pituitary tumors    asperger syndrome    hypogonadism    azoospermia

    2 diseases from the University of Copenhagen DISEASES database for FSHB:
    Aniridia     WAGR syndrome

    FSHB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FSHB gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian hyperstimulation syndrome 71.8 1 18230195 (1)
    gonadotropins increased 66.2 1 16959402 (1)
    pituitary adenoma nonfunctioning 62.8 1 1375599 (1)
    infertility 62.3 4 11299519 (2), 16730882 (1), 17227474 (1)
    puberty delayed 61.7 3 16730882 (1), 9271483 (1), 20067895 (1)
    pituitary adenoma 60.4 4 8881451 (3), 1902844 (1)
    primary amenorrhea 60.4 1 19966036 (1)
    pituitary tumors 56 2 1902844 (1), 1375599 (1)
    azoospermia 55.3 4 16730882 (1), 12568849 (1), 12161499 (1), 10864828 (1)
    hypogonadism 51.4 4 19966036 (1), 9271483 (1), 12568849 (1), 20067895 (1)

    Genatlas disease: FSHB
    delayed puberty,primary amenorrhea,infertility (FSH deficiency,isolated),hypogonadism in man

    Genetic Association Database (GAD): FSHB
    Human Genome Epidemiology (HuGE) Navigator: FSHB (9 documents)

    Export disorders for FSHB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FSHB gene, integrated from 10 sources (see all 216):
    (articles sorted by number of sources associating them with FSHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A reevaluation of the amino acid sequence of human follitropin beta- subunit. (PubMed id 3151250)1, 2, 3 Shome B.... Ward D.N. (J. Protein Chem. 1988)
    2. DNA sequence and regional assignment of the human follicle- stimulating hormone beta-subunit gene to the short arm of human chromosome 11. (PubMed id 2885163)1, 2, 3 Watkins P.C.... Shows T.B. (DNA 1987)
    3. Association of AccI polymorphism in the follicle-stimulating hormone beta gene with polycystic ovary syndrome. (PubMed id 11119757)1, 4, 9 Tong Y....Ng S.C. (Fertil. Steril. 2000)
    4. Increased Prevalance of the -211 T allele of follicle stimulating hormone (FSH) beta subunit promoter polymorphism and lower serum FSH in infertile men. (PubMed id 19897680)1, 4, 9 Grigorova M....Laan M. (J. Clin. Endocrinol. Metab. 2010)
    5. Delayed puberty and hypogonadism caused by mutations in the follicle- stimulating hormone beta-subunit gene. (PubMed id 9271483)1, 2, 9 Layman L.C....Jameson J.L. (N. Engl. J. Med. 1997)
    6. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    7. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    8. Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19574343)1, 4 Ahn J....Hayes R.B. (Hum. Mol. Genet. 2009)
    9. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
    10. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2488 HGNC: 3964 AceView: FSHB Ensembl:ENSG00000131808 euGenes: HUgn2488
    ECgene: FSHB Kegg: 2488 H-InvDB: FSHB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FSHB Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FSHB[genesymbol]
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FSHB
    Wikipedia http://en.wikipedia.org/wiki/Follicle_stimulating_hormone

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FSHB gene:
    Search GeneIP for patents involving FSHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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