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Aliases for FSHB Gene

Aliases for FSHB Gene

  • Follicle Stimulating Hormone Beta Subunit 2 3
  • Follicle Stimulating Hormone, Beta Polypeptide 2 3 5
  • Follicle-Stimulating Hormone Beta Subunit 3 4
  • Follitropin Beta Chain 3 4
  • FSH-Beta 3 4
  • FSH-B 3 4
  • Follitropin, Beta Chain 3
  • Follitropin 2
  • Beta Chain 2
  • HH24 3

External Ids for FSHB Gene

Previous GeneCards Identifiers for FSHB Gene

  • GC11P031850
  • GC11P031028
  • GC11P030292
  • GC11P030217
  • GC11P029945

Summaries for FSHB Gene

Entrez Gene Summary for FSHB Gene

  • The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for FSHB Gene

FSHB (Follicle Stimulating Hormone Beta Subunit) is a Protein Coding gene. Diseases associated with FSHB include Hypogonadotropic Hypogonadism 24 Without Anosmia and Infertility. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. GO annotations related to this gene include hormone activity and follicle-stimulating hormone activity. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for FSHB Gene

  • Stimulates development of follicle and spermatogenesis in the reproductive organs.

Gene Wiki entry for FSHB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSHB Gene

Genomics for FSHB Gene

Regulatory Elements for FSHB Gene

Enhancers for FSHB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FSHB on UCSC Golden Path with GeneCards custom track

Genomic Location for FSHB Gene

30,230,688 bp from pter
30,235,277 bp from pter
4,590 bases
Plus strand

Genomic View for FSHB Gene

Genes around FSHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSHB Gene

Proteins for FSHB Gene

  • Protein details for FSHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Follitropin subunit beta
    Protein Accession:
    Secondary Accessions:
    • A2TF08
    • A5JVV3
    • Q14D61

    Protein attributes for FSHB Gene

    129 amino acids
    Molecular mass:
    14700 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Three dimensional structures from OCA and Proteopedia for FSHB Gene

neXtProt entry for FSHB Gene

Proteomics data for FSHB Gene at MOPED

Post-translational modifications for FSHB Gene

  • Glycosylation at Asn 25 and Asn 42
  • Modification sites at PhosphoSitePlus

Other Protein References for FSHB Gene

No data available for DME Specific Peptides for FSHB Gene

Domains & Families for FSHB Gene

Gene Families for FSHB Gene

Suggested Antigen Peptide Sequences for FSHB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycoprotein hormones subunit beta family.
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with FSHB: view

Function for FSHB Gene

Molecular function for FSHB Gene

GENATLAS Biochemistry:
follicle stimulating hormone,beta polypeptide
UniProtKB/Swiss-Prot Function:
Stimulates development of follicle and spermatogenesis in the reproductive organs.
genes like me logo Genes that share phenotypes with FSHB: view

Human Phenotype Ontology for FSHB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FSHB Gene

MGI Knock Outs for FSHB:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for FSHB Gene

Localization for FSHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSHB Gene


Subcellular locations from

Jensen Localization Image for FSHB Gene COMPARTMENTS Subcellular localization image for FSHB gene
Compartment Confidence
extracellular 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for FSHB Gene

Pathways & Interactions for FSHB Gene

genes like me logo Genes that share pathways with FSHB: view

Gene Ontology (GO) - Biological Process for FSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8220432
GO:0007565 female pregnancy TAS 8220432
GO:0008284 positive regulation of cell proliferation NAS 20613903
GO:0042699 follicle-stimulating hormone signaling pathway IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with FSHB: view

No data available for SIGNOR curated interactions for FSHB Gene

Drugs & Compounds for FSHB Gene

(11) Drugs for FSHB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for FSHB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FSHB: view

Transcripts for FSHB Gene

mRNA/cDNA for FSHB Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSHB Gene

Follicle stimulating hormone, beta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSHB Gene

No ASD Table

Relevant External Links for FSHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSHB Gene

mRNA expression in normal human tissues for FSHB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSHB Gene

This gene is overexpressed in Pituitary (x52.5).

SOURCE GeneReport for Unigene cluster for FSHB Gene Hs.36975

genes like me logo Genes that share expression patterns with FSHB: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FSHB Gene

Orthologs for FSHB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSHB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FSHB 35
  • 86.05 (n)
  • 88.37 (a)
-- 36
  • 85 (a)
  • 88 (a)
(Canis familiaris)
Mammalia FSHB 35
  • 79.59 (n)
  • 79.07 (a)
  • 79 (a)
(Mus musculus)
Mammalia Fshb 35
  • 85.01 (n)
  • 86.05 (a)
Fshb 16
Fshb 36
  • 85 (a)
(Pan troglodytes)
Mammalia FSHB 35
  • 98.45 (n)
  • 98.45 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Fshb 35
  • 83.98 (n)
  • 82.95 (a)
(Monodelphis domestica)
Mammalia FSHB 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia FSHB 36
  • 70 (a)
(Gallus gallus)
Aves FSHB 35
  • 72.22 (n)
  • 68.25 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia FSHB 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fshb 35
  • 63.82 (n)
  • 55.81 (a)
(Danio rerio)
Actinopterygii fshb 35
  • 55.43 (n)
  • 47.83 (a)
fshb 36
  • 38 (a)
Species with no ortholog for FSHB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSHB Gene

Gene Tree for FSHB (if available)
Gene Tree for FSHB (if available)

Paralogs for FSHB Gene

Paralogs for FSHB Gene

(9) SIMAP similar genes for FSHB Gene using alignment to 3 proteins: Pseudogenes for FSHB Gene

genes like me logo Genes that share paralogs with FSHB: view

Variants for FSHB Gene

Sequence variations from dbSNP and Humsavar for FSHB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_012047 -
VAR_033015 Hypogonadotropic hypogonadism 24 without anosmia (HH24)

Structural Variations from Database of Genomic Variants (DGV) for FSHB Gene

Variant ID Type Subtype PubMed ID
nsv437712 CNV Loss 16327808

Variation tolerance for FSHB Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSHB Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSHB Gene

Disorders for FSHB Gene

MalaCards: The human disease database

(9) MalaCards diseases for FSHB Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 24 without anosmia
  • follicle-stimulating hormone deficiency, isolated
  • absence of menstruation
  • spermatogenic failure
- elite association - COSMIC cancer census association via MalaCards
Search FSHB in MalaCards View complete list of genes associated with diseases


  • Hypogonadotropic hypogonadism 24 without anosmia (HH24) [MIM:229070]: A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH24 is characterized by primary amenorrhea in women, oligo or azoospermia with low to normal testosterone levels in men, and infertility. {ECO:0000269 PubMed:8220432, ECO:0000269 PubMed:9271483, ECO:0000269 PubMed:9280841}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FSHB Gene

delayed puberty,primary amenorrhea,infertility (FSH deficiency,isolated),hypogonadism in man

Relevant External Links for FSHB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FSHB: view

Publications for FSHB Gene

  1. A reevaluation of the amino acid sequence of human follitropin beta- subunit. (PMID: 3151250) Shome B. … Ward D.N. (J. Protein Chem. 1988) 2 3 4 67
  2. Increased Prevalance of the -211 T allele of follicle stimulating hormone (FSH) beta subunit promoter polymorphism and lower serum FSH in infertile men. (PMID: 19897680) Grigorova M. … Laan M. (J. Clin. Endocrinol. Metab. 2010) 3 23
  3. FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes. (PMID: 20233786) Corpuz P.S. … Coss D. (Mol. Endocrinol. 2010) 3 23
  4. Isolated follicle-stimulating hormone (FSH) deficiency without mutation of the FSHbeta gene and successful treatment with human menopausal gonadotropin. (PMID: 18402948) Murao K. … Ishida T. (Fertil. Steril. 2008) 3 23
  5. Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity. (PMID: 18653705) Wang Y. … Bernard D.J. (Endocrinology 2008) 3 23

Products for FSHB Gene

Sources for FSHB Gene