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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FSD2 Gene

protein-coding   GIFtS: 43
GCID: GC15M083424

Fibronectin Type III And SPRY Domain Containing 2

(Previous name: SPRY domain containing 1)
(Previous symbol: SPRYD1)
  Search for FSD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibronectin Type III And SPRY Domain Containing 21 2
SPRYD11 2 3
SPRY Domain Containing 11 2
SPRY Domain-Containing Protein 12 3
Fibronectin Type III And SPRY Domain-Containing Protein 22

External Ids:    HGNC: 180241   Entrez Gene: 1237222   Ensembl: ENSG000001866287   UniProtKB: A1L4K13   

Export aliases for FSD2 gene to outside databases

Previous GC identifer: GC15M081222


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FSD2 Gene:
This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for FSD2 Gene: 
FSD2 (fibronectin type III and SPRY domain containing 2) is a protein-coding gene. An important paralog of this gene is CMYA5.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_077661.3  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FSD2 gene promoter:
         RFX1   FOXF2   GCNF   MIF-1   YY1   GCNF-1   SEF-1 (1)   Meis-1a   GCNF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FSD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

FSD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSD2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M083424:  view genomic region     (about GC identifiers)

Start:
83,424,114 bp from pter      End:
83,474,822 bp from pter
Size:
50,709 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FSD2_HUMAN, A1L4K1 (See protein sequence)
Recommended Name: Fibronectin type III and SPRY domain-containing protein 2  
Size: 749 amino acids; 85385 Da
Secondary accessions: B3KVG1

Explore the universe of human proteins at neXtProt for FSD2: NX_A1L4K1

Explore proteomics data for FSD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A1L4K1

  • FSD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FSD2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001007123.1  NP_001268734.1  NP_001268735.1  

    ENSEMBL proteins: 
     ENSP00000335651   ENSP00000444078   ENSP00000453127  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing

    5/6 InterPro protein domains (see all 6):
     IPR001870 B30.2/SPRY
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003879 Butyrophylin
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry A1L4K1

    ProtoNet protein and cluster: A1L4K1

    UniProtKB/Swiss-Prot: FSD2_HUMAN, A1L4K1
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 2 fibronectin type-III domains


    FSD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FSD2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSD2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FSD2

    Search CenterWatch for drugs/clinical trials and news about FSD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for FSD2 gene (3 alternative transcripts): 
    NM_001007122.3  NM_001281805.1  NM_001281806.1  

    Unigene Cluster for FSD2:

    Fibronectin type III and SPRY domain containing 2
    Hs.719372  [show with all ESTs]
    Unigene Representative Sequence: AL833295
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334574(uc002bjd.2 uc010uol.1 uc010uom.1) ENST00000541889
    ENST00000561368
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    Additional mRNA sequence: 

    AK122875.1 AL833295.1 BC130569.1 BC144175.1 BC144181.1 

    4 DOTS entries:

    DT.75131708  DT.100022694  DT.75101703  DT.441771 

    20 AceView cDNA sequences:

    AK122875 AI205610 AI221164 BX094891 AI375128 AI425086 AA972178 AA824642 
    AW183935 AL833295 F34462 BF576055 F23318 AW339890 C03376 BU659119 
    AW978717 AA247169 AA095967 C04480 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FSD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCAGCAC
    FSD2 Expression
    About this image


    See FSD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FSD2

    SOURCE GeneReport for Unigene cluster: Hs.719372
        SABiosciences Custom PCR Arrays for FSD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FSD2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fsd21 , 5 fibronectin type III and SPRY domain containing 21, 5 83.4(n)1
    83.03(a)1
      7 (45.71 cM)5
    2440911  NM_172904.21  NP_766492.21 
     815343545 
    chicken
    (Gallus gallus)
    Aves FSD21 fibronectin type III and SPRY domain containing 2 64.36(n)
    57.57(a)
      427503  XM_425075.3  XP_425075.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    54(a)
    52(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039153(2554-9079)
    GL343657.1(193709-198137)
    zebrafish
    (Danio rerio)
    Actinopterygii FSD26
    fibronectin type III and SPRY domain containing 2
    41(a)
    1 ↔ 1
    18(13389-20363)


    ENSEMBL Gene Tree for FSD2 (if available)
    TreeFam Gene Tree for FSD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FSD2 gene
    CMYA52  SPRYD42  
    1 SIMAP similar gene for FSD2 using alignment to 4 protein entries:     FSD2_HUMAN (see all proteins):
    MEFV

    FSD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/951 SNPs in FSD2 are shown (see all 951)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80238731,2
    C,F,A,H--83427684(+) CCTCTC/TGCCTT 1 -- ds5001 ese325Minor allele frequency- T:0.20NS EA NA CSA WA 2904
    rs745696441,2
    F--83427818(+) TACACG/AAATAT 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1904101901,2
    --83427849(+) TTTTGA/TGTTCG 1 -- ds50010--------
    rs1179986501,2
    C,F--83427854(+) AGTTCG/ATTTAG 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1481357231,2
    --83427859(+) GTTTAA/GTCTGA 1 -- ds50010--------
    rs1501198301,2
    --83428043(+) AAGGCG/TTGAGC 1 -- ut310--------
    rs1387025461,2
    C--83428091(+) GACATC/TAGAAT 1 -- ut310--------
    rs2013931871,2
    C--83428126(+) TGGCAC/TTGAAA 2 M V mis10--------
    rs2020185851,2
    C--83428128(+) GCATTA/GAAATG 2 S L mis10--------
    rs1427018201,2
    C--83428175(+) GAAAAA/GCAGGG 2 C syn10--------

    HapMap Linkage Disequilibrium report for FSD2 (83424114 - 83474822 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FSD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674021CNV Deletion23128226
    esv34318CNV Loss17911159
    nsv817702CNV Loss17921354
    nsv471687CNV Gain15918152
    nsv469557CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FSD2 for disorders           About MalaCards

    FSD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FSD2
    Human Genome Epidemiology (HuGE) Navigator: FSD2 (1 document)

    Export disorders for FSD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FSD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FSD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics. (PubMed id 20966410)1, 4 Dong C....Sacco R.L. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 123722 HGNC: 18024 AceView: LOC123722 Ensembl:ENSG00000186628 euGenes: HUgn123722
    ECgene: FSD2 H-InvDB: FSD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FSD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FSD2 gene:
    Search GeneIP for patents involving FSD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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