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Aliases for FSD2 Gene

Aliases for FSD2 Gene

  • Fibronectin Type III And SPRY Domain Containing 2 2 3 5
  • SPRY Domain-Containing Protein 1 3 4
  • SPRY Domain Containing 1 2 3
  • SPRYD1 3 4
  • Fibronectin Type III And SPRY Domain-Containing Protein 2 3

External Ids for FSD2 Gene

Previous HGNC Symbols for FSD2 Gene

  • SPRYD1

Previous GeneCards Identifiers for FSD2 Gene

  • GC15M081222
  • GC15M083424

Summaries for FSD2 Gene

Entrez Gene Summary for FSD2 Gene

  • This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for FSD2 Gene

FSD2 (Fibronectin Type III And SPRY Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is CMYA5.

Additional gene information for FSD2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSD2 Gene

Genomics for FSD2 Gene

Regulatory Elements for FSD2 Gene

Enhancers for FSD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H082848 1.3 Ensembl ENCODE 10.6 -43.9 -43856 2 HNRNPUL1 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FAM103A1 C15orf40 WHAMM HOMER2 FSD2 EFL1 GOLGA6L9 GC15M082841 GC15P082870
GH15H082749 1.1 ENCODE 10.7 +55.4 55376 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 AP3B2 FSD2 EFL1 HOMER2 C15orf40 HDGFL3 GOLGA6L10 GC15M082753 SNHG21
GH15H082852 0.8 Ensembl ENCODE 10.5 -47.1 -47085 1 NFIC ZNF316 NFIB SCRT2 MAFG EMSY MAFK FAM103A1 C15orf40 HOMER2 FSD2 WHAMM GC15M082841 GC15P082870
GH15H082950 0.8 ENCODE 9.8 -145.9 -145940 2 NFIB FEZF1 GLIS2 ZSCAN5C RUNX3 EGR2 ZEB2 ZNF398 NFIL3 NFIC FAM103A1 AP3B2 C15orf40 FSD2 GC15M082960 PIR42152
GH15H082741 0.4 ENCODE 16.4 +63.9 63876 1 SETDB1 AP3B2 FSD2 GOLGA6L9 ACTG1P17 ENSG00000259442
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FSD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FSD2 Gene

82,755,362 bp from pter
82,806,211 bp from pter
50,850 bases
Minus strand

Genomic View for FSD2 Gene

Genes around FSD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSD2 Gene

Proteins for FSD2 Gene

  • Protein details for FSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III and SPRY domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KVG1
    • B7ZM02

    Protein attributes for FSD2 Gene

    749 amino acids
    Molecular mass:
    85385 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FSD2 Gene


neXtProt entry for FSD2 Gene

Post-translational modifications for FSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FSD2 Gene

Domains & Families for FSD2 Gene

Gene Families for FSD2 Gene

Suggested Antigen Peptide Sequences for FSD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSD2: view

No data available for UniProtKB/Swiss-Prot for FSD2 Gene

Function for FSD2 Gene

Gene Ontology (GO) - Molecular Function for FSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FSD2: view

Phenotypes for FSD2 Gene

GenomeRNAi human phenotypes for FSD2:
genes like me logo Genes that share phenotypes with FSD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FSD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSD2 Gene

Localization for FSD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSD2 gene
Compartment Confidence
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FSD2 Gene

Pathways & Interactions for FSD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FSD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for FSD2 Gene

Drugs & Compounds for FSD2 Gene

No Compound Related Data Available

Transcripts for FSD2 Gene

Unigene Clusters for FSD2 Gene

Fibronectin type III and SPRY domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FSD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FSD2 Gene

No ASD Table

Relevant External Links for FSD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSD2 Gene

mRNA differential expression in normal tissues according to GTEx for FSD2 Gene

This gene is overexpressed in Muscle - Skeletal (x9.6), Heart - Left Ventricle (x9.4), and Heart - Atrial Appendage (x6.3).

Protein differential expression in normal tissues from HIPED for FSD2 Gene

This gene is overexpressed in Breast (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSD2 Gene

Protein tissue co-expression partners for FSD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FSD2 Gene:


SOURCE GeneReport for Unigene cluster for FSD2 Gene:


Evidence on tissue expression from TISSUES for FSD2 Gene

  • Muscle(2.2)
genes like me logo Genes that share expression patterns with FSD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSD2 Gene

Orthologs for FSD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FSD2 33 34
  • 99.43 (n)
(Bos Taurus)
Mammalia FSD2 33 34
  • 87.02 (n)
(Rattus norvegicus)
Mammalia Fsd2 33
  • 83.49 (n)
(Mus musculus)
Mammalia Fsd2 33 16 34
  • 83.38 (n)
(Canis familiaris)
Mammalia FSD2 33 34
  • 82.71 (n)
(Monodelphis domestica)
Mammalia FSD2 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia FSD2 34
  • 66 (a)
(Gallus gallus)
Aves FSD2 33 34
  • 64.11 (n)
(Anolis carolinensis)
Reptilia FSD2 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fsd2 33
  • 59.02 (n)
(Danio rerio)
Actinopterygii FSD2 34
  • 44 (a)
Species where no ortholog for FSD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSD2 Gene

Gene Tree for FSD2 (if available)
Gene Tree for FSD2 (if available)

Paralogs for FSD2 Gene

Paralogs for FSD2 Gene

(1) SIMAP similar genes for FSD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FSD2: view

Variants for FSD2 Gene

Sequence variations from dbSNP and Humsavar for FSD2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000078693 -- 82,808,340(+) TTAAA(A/G)TAGGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000100041 -- 82,771,924(+) CCTTT(C/T)TGCCC intron-variant
rs1000153013 -- 82,765,032(+) TTAGG(C/G)TCCTC intron-variant
rs1000217024 -- 82,778,456(+) ACTCC(A/G)TGATT intron-variant
rs1000220462 -- 82,774,418(+) ATATG(A/T)TGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSD2 Gene

Variant ID Type Subtype PubMed ID
dgv2637n100 CNV gain 25217958
esv2674021 CNV deletion 23128226
esv34318 CNV loss 17911159
esv3581791 CNV loss 25503493
nsv1120052 OTHER inversion 24896259
nsv469557 CNV loss 16826518
nsv471687 CNV gain 15918152
nsv817702 CNV loss 17921354

Variation tolerance for FSD2 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSD2 Gene

Disorders for FSD2 Gene

Relevant External Links for FSD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FSD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSD2 Gene

Publications for FSD2 Gene

  1. Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics. (PMID: 20966410) Dong C … Sacco RL (Stroke 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 60

Products for FSD2 Gene

Sources for FSD2 Gene

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