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Aliases for FSD1L Gene

Aliases for FSD1L Gene

  • Fibronectin Type III And SPRY Domain Containing 1 Like 2 3 5
  • Cystatin And DUF19 Domain Containing 1 2 3
  • Coiled-Coil Domain Containing 10 2 3
  • CSDUFD1 3 4
  • CCDC10 3 4
  • FSD1CL 3 4
  • FSD1NL 3 4
  • Fibronectin Type III And SPRY Domain Containing 1-Like 2
  • Coiled-Coil Domain-Containing Protein 10 4
  • FSD1 N-Terminal-Like Protein 4
  • FSD1 C-Terminal Like 3
  • FSD1 N-Terminal Like 3
  • FSD1-Like Protein 3
  • MIR1 3

External Ids for FSD1L Gene

Previous HGNC Symbols for FSD1L Gene

  • CSDUFD1
  • CCDC10
  • FSD1NL
  • FSD1CL

Previous GeneCards Identifiers for FSD1L Gene

  • GC09P105343
  • GC09P107250
  • GC09P108210
  • GC09P077813

Summaries for FSD1L Gene

GeneCards Summary for FSD1L Gene

FSD1L (Fibronectin Type III And SPRY Domain Containing 1 Like) is a Protein Coding gene. An important paralog of this gene is FSD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSD1L Gene

Genomics for FSD1L Gene

Regulatory Elements for FSD1L Gene

Enhancers for FSD1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F105504 1 FANTOM5 Ensembl 12.3 +61.9 61859 0.2 TBP BACH1 RELA ZNF316 POLR2A NFE2 MAFK NFE2L2 MTA2 MAFG FSD1L TMEM38B RALGAPA1P1
GH09F105509 0.8 FANTOM5 Ensembl ENCODE 10.9 +67.9 67892 1.1 ZNF76 INSM2 KLF17 FEZF1 RAD21 YY1 ZNF335 ZNF366 ZNF362 ZNF654 FSD1L TMEM38B RALGAPA1P1
GH09F105500 0.8 Ensembl ENCODE 10.7 +58.5 58459 1.4 TBP MXI1 BMI1 EBF1 RELA POLR2A EED CHD2 MTA2 JUNB FSD1L FKTN RALGAPA1P1
GH09F105506 0.7 ENCODE 10.7 +64.8 64782 1.3 SOX13 CTCF SAP130 RARA GATA3 NR2F6 PRDM10 CREM HOMEZ GATAD2A FSD1L RALGAPA1P1
GH09F105557 0.5 ENCODE 7.8 +116.0 116004 1.5 HDGF ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 CBX5 DEK SP3 FSD1L FKTN LOC105376199
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FSD1L on UCSC Golden Path with GeneCards custom track

Genomic Location for FSD1L Gene

Chromosome:
9
Start:
105,442,242 bp from pter
End:
105,552,433 bp from pter
Size:
110,192 bases
Orientation:
Plus strand

Genomic View for FSD1L Gene

Genes around FSD1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSD1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSD1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSD1L Gene

Proteins for FSD1L Gene

  • Protein details for FSD1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXM9-FSD1L_HUMAN
    Recommended name:
    FSD1-like protein
    Protein Accession:
    Q9BXM9
    Secondary Accessions:
    • A2A338
    • A6NKH7
    • B7Z5S6
    • B7Z5W3
    • Q5T879
    • Q5T880

    Protein attributes for FSD1L Gene

    Size:
    530 amino acids
    Molecular mass:
    59578 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FSD1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSD1L Gene

Post-translational modifications for FSD1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FSD1L Gene

Domains & Families for FSD1L Gene

Gene Families for FSD1L Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXM9

UniProtKB/Swiss-Prot:

FSD1L_HUMAN :
  • Contains 1 B30.2/SPRY domain.
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 COS domain.
  • Contains 1 fibronectin type-III domain.
genes like me logo Genes that share domains with FSD1L: view

Function for FSD1L Gene

Gene Ontology (GO) - Molecular Function for FSD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FSD1L: view
genes like me logo Genes that share phenotypes with FSD1L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSD1L Gene

Localization for FSD1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSD1L Gene COMPARTMENTS Subcellular localization image for FSD1L gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FSD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FSD1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FSD1L Gene

Pathways & Interactions for FSD1L Gene

SuperPathways for FSD1L Gene

No Data Available

Interacting Proteins for FSD1L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000417492%0d%0a9606.ENSP00000430432%0d%0a
Selected Interacting proteins: ENSP00000417492 Q9BXM9-FSD1L_HUMAN for FSD1L Gene via STRING IID

Gene Ontology (GO) - Biological Process for FSD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FSD1L: view

No data available for Pathways by source and SIGNOR curated interactions for FSD1L Gene

Transcripts for FSD1L Gene

mRNA/cDNA for FSD1L Gene

Unigene Clusters for FSD1L Gene

Fibronectin type III and SPRY domain containing 1-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSD1L Gene

No ASD Table

Relevant External Links for FSD1L Gene

GeneLoc Exon Structure for
FSD1L
ECgene alternative splicing isoforms for
FSD1L

Expression for FSD1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FSD1L Gene

Protein differential expression in normal tissues from HIPED for FSD1L Gene

This gene is overexpressed in Fetal Brain (22.0), Spinal cord (12.8), Testis (12.1), and Brain (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FSD1L Gene



Protein tissue co-expression partners for FSD1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FSD1L Gene:

FSD1L

SOURCE GeneReport for Unigene cluster for FSD1L Gene:

Hs.136901
genes like me logo Genes that share expression patterns with FSD1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FSD1L Gene

Orthologs for FSD1L Gene

This gene was present in the common ancestor of animals.

Orthologs for FSD1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSD1L 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia FSD1L 34 35
  • 94.15 (n)
cow
(Bos Taurus)
Mammalia FSD1L 34 35
  • 93.6 (n)
oppossum
(Monodelphis domestica)
Mammalia FSD1L 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fsd1l 34 16 35
  • 90.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FSD1L 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fsd1l 34
  • 88.42 (n)
chicken
(Gallus gallus)
Aves FSD1L 34 35
  • 74.62 (n)
lizard
(Anolis carolinensis)
Reptilia FSD1L 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fsd1l 34
  • 77.21 (n)
zebrafish
(Danio rerio)
Actinopterygii fsd1l 34 35
  • 67.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta Trim9 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 35
  • 14 (a)
OneToMany
Species where no ortholog for FSD1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FSD1L Gene

ENSEMBL:
Gene Tree for FSD1L (if available)
TreeFam:
Gene Tree for FSD1L (if available)

Paralogs for FSD1L Gene

(2) SIMAP similar genes for FSD1L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FSD1L: view

Variants for FSD1L Gene

Sequence variations from dbSNP and Humsavar for FSD1L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10283751 -- 105,462,123(+) TTATG(C/G)TAAGG intron-variant
rs10481710 -- 105,467,321(+) AGTTC(A/G)CTTCT intron-variant, upstream-variant-2KB
rs10491808 -- 105,552,006(-) TTAAC(A/G)AGATT utr-variant-3-prime
rs10491809 -- 105,550,618(-) TTAGG(C/T)TAATC utr-variant-3-prime
rs10739910 -- 105,513,496(+) ATGAA(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSD1L Gene

Variant ID Type Subtype PubMed ID
esv3891705 CNV loss 25118596
nsv1037750 CNV gain 25217958
nsv1053973 CNV loss 25217958
nsv1110046 CNV deletion 24896259
nsv416298 CNV deletion 16902084
nsv615115 CNV loss 21841781
nsv982334 CNV duplication 23825009

Variation tolerance for FSD1L Gene

Gene Damage Index Score: 2.67; 45.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSD1L Gene

Human Gene Mutation Database (HGMD)
FSD1L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSD1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSD1L Gene

Disorders for FSD1L Gene

Relevant External Links for FSD1L

Genetic Association Database (GAD)
FSD1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSD1L

No disorders were found for FSD1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSD1L Gene

Publications for FSD1L Gene

  1. Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. (PMID: 11267680) Carim-Todd L. … Sumoy L. (Biochim. Biophys. Acta 2001) 2 3 4 64
  2. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. (PMID: 19448620) Perry J.R. … Murabito J.M. (Nat. Genet. 2009) 3 46 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 3 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for FSD1L Gene

Sources for FSD1L Gene

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