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Aliases for FSD1 Gene

Aliases for FSD1 Gene

  • Fibronectin Type III And SPRY Domain Containing 1 2 3 5
  • Fibronectin Type 3 And SPRY Domain Containing 1 2 3
  • Microtubule-Associated Protein GLFND 3 4
  • MID1-Related Protein 1 3 4
  • GLFND 3 4
  • MIR1 3 4
  • Fibronectin Type 3 And SPRY (Spla, Ryanodine) Domain Containing (With Coiled-Coil Motif) 1 3
  • Fibronectin Type III And SPRY Domain-Containing Protein 1 3
  • Midline 1-Related Protein 1 3

External Ids for FSD1 Gene

Previous GeneCards Identifiers for FSD1 Gene

  • GC19P004397
  • GC19P004244
  • GC19P004255
  • GC19P004068

Summaries for FSD1 Gene

Entrez Gene Summary for FSD1 Gene

  • This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009]

GeneCards Summary for FSD1 Gene

FSD1 (Fibronectin Type III And SPRY Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is FSD1L.

UniProtKB/Swiss-Prot for FSD1 Gene

  • May be involved in microtubule organization and stabilization.

Additional gene information for FSD1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSD1 Gene

Genomics for FSD1 Gene

Regulatory Elements for FSD1 Gene

Enhancers for FSD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H004367 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +70.2 70227 14 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ENSG00000267769 CACTIN SEMA6B CHAF1A CCDC94 ENSG00000267030 SH3GL1 UBXN6 HDGFL2 CACTIN-AS1
GH19H004142 1.6 Ensembl ENCODE dbSUPER 10.7 -158.0 -158021 7 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CACTIN SIRT6 ANKRD24 MAP2K2 FSD1 TMIGD2 CCDC94 CREB3L3 LRG1 GC19P004136
GH19H003719 1.6 Ensembl ENCODE dbSUPER 9.9 -583.5 -583501 4 HDGF PKNOX1 ARNT SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 SP3 CACTIN ZNF77 ZNF555 MRPL54 ZNF554 HDGFL2 APBA3 CACTIN-AS1 GNA11 TLE2
GH19H004129 1.5 Ensembl ENCODE dbSUPER 10.1 -173.4 -173431 2 PKNOX1 ATF1 FOXA2 ARNT ARID4B SIN3A TCF12 ZNF121 GATA2 FOS CREB3L3 ANKRD24 SIRT6 CACTIN-AS1 APBA3 CACTIN EEF2 TMIGD2 FSD1 ENSG00000269807
GH19H004340 1.1 ENCODE 12.4 +37.8 37847 3 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 STAP2 SH3GL1 ENSG00000267255 TMIGD2 FSD1 SHD CHAF1A CCDC94 ENSG00000269425
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FSD1 on UCSC Golden Path with GeneCards custom track

Promoters for FSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106186 206 401 MXI1 KLF1 RB1 SUZ12 ZNF76 ETS1 MTA3 CTBP1 POLR2A ZNF143

Genomic Location for FSD1 Gene

Chromosome:
19
Start:
4,304,594 bp from pter
End:
4,323,846 bp from pter
Size:
19,253 bases
Orientation:
Plus strand

Genomic View for FSD1 Gene

Genes around FSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSD1 Gene

Proteins for FSD1 Gene

  • Protein details for FSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTV5-FSD1_HUMAN
    Recommended name:
    Fibronectin type III and SPRY domain-containing protein 1
    Protein Accession:
    Q9BTV5
    Secondary Accessions:
    • B2RDT0
    • Q9BXN0
    • Q9HAG4

    Protein attributes for FSD1 Gene

    Size:
    496 amino acids
    Molecular mass:
    55820 Da
    Quaternary structure:
    • Oligomerization is required for binding to microtubules.

neXtProt entry for FSD1 Gene

Post-translational modifications for FSD1 Gene

  • Ubiquitination at isoforms=13
  • Modification sites at PhosphoSitePlus

Other Protein References for FSD1 Gene

No data available for DME Specific Peptides for FSD1 Gene

Domains & Families for FSD1 Gene

Gene Families for FSD1 Gene

Suggested Antigen Peptide Sequences for FSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTV5

UniProtKB/Swiss-Prot:

FSD1_HUMAN :
  • B30.2 box contains a microtubule-binding site.
Domain:
  • B30.2 box contains a microtubule-binding site.
genes like me logo Genes that share domains with FSD1: view

Function for FSD1 Gene

Molecular function for FSD1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in microtubule organization and stabilization.

Phenotypes for FSD1 Gene

GenomeRNAi human phenotypes for FSD1:
genes like me logo Genes that share phenotypes with FSD1: view

Animal Model Products

CRISPR Products

miRNA for FSD1 Gene

miRTarBase miRNAs that target FSD1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FSD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSD1 Gene

Localization for FSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Cleavage furrow. Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for FSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with FSD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FSD1 Gene

Pathways & Interactions for FSD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FSD1: view

No data available for Pathways by source and SIGNOR curated interactions for FSD1 Gene

Drugs & Compounds for FSD1 Gene

No Compound Related Data Available

Transcripts for FSD1 Gene

Unigene Clusters for FSD1 Gene

Fibronectin type III and SPRY domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FSD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FSD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b
SP1:
SP2: -
SP3: -

Relevant External Links for FSD1 Gene

GeneLoc Exon Structure for
FSD1
ECgene alternative splicing isoforms for
FSD1

Expression for FSD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSD1 Gene

mRNA differential expression in normal tissues according to GTEx for FSD1 Gene

This gene is overexpressed in Brain - Cortex (x6.4), Brain - Frontal Cortex (BA9) (x5.4), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Hippocampus (x4.4), Brain - Cerebellum (x4.1), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for FSD1 Gene

This gene is overexpressed in Fetal Brain (33.2), Testis (15.9), and Frontal cortex (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FSD1 Gene



Protein tissue co-expression partners for FSD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FSD1 Gene:

FSD1

SOURCE GeneReport for Unigene cluster for FSD1 Gene:

Hs.28144

mRNA Expression by UniProt/SwissProt for FSD1 Gene:

Q9BTV5-FSD1_HUMAN
Tissue specificity: Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord.

Evidence on tissue expression from TISSUES for FSD1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with FSD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSD1 Gene

Orthologs for FSD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSD1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FSD1 33 34
  • 91.6 (n)
cow
(Bos Taurus)
Mammalia FSD1 33 34
  • 91.33 (n)
oppossum
(Monodelphis domestica)
Mammalia FSD1 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fsd1 33 16 34
  • 86.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FSD1 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FSD1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fsd1 33
  • 69.15 (n)
zebrafish
(Danio rerio)
Actinopterygii fsd1 33 34
  • 67.41 (n)
Dr.16576 33
fruit fly
(Drosophila melanogaster)
Insecta Trim9 34
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 34
  • 13 (a)
OneToMany
Species where no ortholog for FSD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FSD1 Gene

ENSEMBL:
Gene Tree for FSD1 (if available)
TreeFam:
Gene Tree for FSD1 (if available)

Paralogs for FSD1 Gene

(2) SIMAP similar genes for FSD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FSD1: view

Variants for FSD1 Gene

Sequence variations from dbSNP and Humsavar for FSD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000028241 -- 4,308,891(+) TAGGA(C/T)GGTGA intron-variant
rs1000035569 -- 4,306,916(+) CTCCC(A/G)TGGGC intron-variant
rs1000199429 -- 4,309,186(+) AAGGT(C/T)ACAAT intron-variant
rs1000303847 -- 4,314,576(+) CCGCC(C/T)CCTGG intron-variant
rs1000474710 -- 4,310,256(+) GTTGT(C/T)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSD1 Gene

Variant ID Type Subtype PubMed ID
esv1106527 CNV insertion 17803354
nsv1119469 CNV insertion 24896259
nsv1144859 CNV deletion 24896259
nsv458328 CNV gain 19166990
nsv578442 CNV loss 21841781
nsv578443 CNV gain 21841781
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897

Variation tolerance for FSD1 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSD1 Gene

Disorders for FSD1 Gene

Relevant External Links for FSD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSD1

No disorders were found for FSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSD1 Gene

Publications for FSD1 Gene

  1. A novel centrosome-associated protein with affinity for microtubules. (PMID: 12154070) Stein PA … Rapoport TA (Journal of cell science 2002) 3 4 22 60
  2. Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. (PMID: 11267680) Carim-Todd L … Sumoy L (Biochimica et biophysica acta 2001) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy. (PMID: 12445389) Manabe Ri … Horwitz AR (Current biology : CB 2002) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for FSD1 Gene

Sources for FSD1 Gene

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