FSD1 Gene
protein-coding GIFtS: 48
GCID: GC19P004304
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|
fibronectin type III and SPRY domain containing 1(Previous name: fibronectin type 3 and SPRY domain containing 1 )
| |
Aliases
for FSD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibronectin Type III And SPRY Domain Containing 11 2 | | MID1-Related Protein 12 3 | | MIR11 2 3 | | MGC32131 | | GLFND2 3 5 | | Fibronectin Type 3 And SPRY (Spla, Ryanodine) Domain Containing (WithCoiled-Coil Motif) 12 | | Fibronectin Type 3 And SPRY Domain Containing 11 2 | | Fibronectin Type III And SPRY Domain-Containing Protein 12 | | Microtubule-Associated Protein GLFND2 3 | | Midline 1-Related Protein 12 |
Export aliases for FSD1 gene to outside databasesPrevious GC identifers: GC19P004397 GC19P004244 GC19P004255 GC19P004068 |
Summaries
for FSD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FSD1:
This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstreamof B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain.The encoded protein associates with a subset of microtubules and may be involved in the stability and organization ofmicrotubules during cytokinesis. (provided by RefSeq, Apr 2009)
UniProtKB/Swiss-Prot: FSD1_HUMAN, Q9BTV5Function: May be involved in microtubule organization and stabilization
|
Genomic Views
for FSD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FSD1 gene promoter:
Elk-1 RFX1 CUTL1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Tal-1beta POU3F2 c-Ets-1 GATA-2 HOXA5
Other transcription factors
Search SABiosciences Chromatin IP Primers for FSD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3FSD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P004304: view genomic region
(about GC identifiers)
Start:
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4,304,591 bp from pter |
End:
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4,323,843 bp from pter |
Size:
|
19,253 bases |
Orientation:
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plus strand |
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Proteins
for FSD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FSD1_HUMAN, Q9BTV5 (See
protein sequence)Recommended Name: Fibronectin type III and SPRY domain-containing protein 1 Size: 496 amino acids; 55820 Da
Subunit: Oligomerization is required for binding to microtubules
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Nucleus. Cytoplasm. Cleavage furrow.Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does notassociates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to thecentral portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in thecleavage furrow, not present in the mitotic spindle
Secondary accessions: B2RDT0 Q9BXN0 Q9HAG4Explore the universe of human proteins at neXtProt for FSD1: NX_Q9BTV5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BTV5
FSD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077309.1
ENSEMBL proteins: ENSP00000221856
Human Recombinant Protein Products for FSD1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
FSD1 for ontologies About GeneDecksing
FSD1 Antibody Products:
Assay Products for FSD1: |
Protein
Domains /
Families
for FSD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FSD1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9BTV5ProtoNet protein and cluster: Q9BTV5 UniProtKB/Swiss-Prot: FSD1_HUMAN, Q9BTV5Domain: B30.2 box contains a microtubule-binding siteSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 COS domainSimilarity: Contains 1 fibronectin type-III domain |
Function
for FSD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FSD1_HUMAN, Q9BTV5Function: May be involved in microtubule organization and stabilizationPhenotypes:
1 GenomeRNAi human phenotype for FSD1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FSD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSD1 |
|
Pathways & Interactions
for FSD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSD1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for FSD1 (Q9BTV52, 3 ENSP000002218564) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
FSD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FSD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FSD1
Search CenterWatch for drugs/clinical trials and news about FSD1
|
Transcripts
for FSD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FSD1 gene: NM_024333.2 Unigene Cluster for FSD1: Fibronectin type III and SPRY domain containing 1 Hs.28144 [show with all ESTs]Unigene Representative Sequence: NM_0243331 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000221856(uc010xie.2 uc010xif.2 uc002lzy.2 uc002maa.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FSD1 (NM_001120) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FSD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSD1 |
Additional cDNA sequence: AF316829.1 AK021750.1 AK295523.1 AK303606.1 AK315661.1 AY032617.1 BC003124.1 BC016442.1 7 DOTS entries: DT.441105 DT.95273524 DT.100648713 DT.121502386 DT.40302148 DT.91756148 DT.99988541 24/146 AceView cDNA sequences (see all 146): BE741433 BC016442 CR622179 BI755769 BF513717 CB153084 NM_024333 BM559641 CR622875 BC003124 BP364720 BM916517 BQ890482 BM916228 CR602397 CR623547 BF526205 BM683389 BM561105 BG913686 BM793852 BE255498 CR610791 CR599769
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FSD1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for FSD1
|
Expression
for FSD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FSD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCGCCTGG
About this image
See FSD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FSD1
SOURCE GeneReport for Unigene cluster: Hs.28144
UniProtKB/Swiss-Prot: FSD1_HUMAN, Q9BTV5Tissue specificity: Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole,frontal lobe, temporal lobe and putamen. Lower expression in spinal chord
SABiosciences Custom PCR Arrays for FSD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FSD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSD1 |
Orthologs
for FSD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FSD1 gene from 1/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.165762 |
Transcribed sequence with weak similarity to protein more |
76.39(n) |
|
BI476785.1 |
ENSEMBL Gene Tree for FSD1 (if available)
TreeFam Gene Tree for FSD1 (if available) |
Paralogs
for FSD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FSD1 gene
- TRIM132 FSD1L2 TRIM462 TRIM632 TRIM592 TRIM672 TRIM92 TRIM362
- MID22 MID12 TRIM552 TRIM542
2 SIMAP similar genes for FSD1 using alignment to 5 protein entries: FSD1_HUMAN (see all proteins):FSD1L MID1
FSD1 for paralogs About GeneDecksing
|
Genomic Variants
for FSD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FSD1 (4304591 - 4323843 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FSD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSD1 |
|
Disorders
/ Diseases
for FSD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FSD1 for disorders About GeneDecksing
OMIM gene information: 609828
OMIM disorders: --
1  disease for FSD1: About MalaCardscerebritis
Export disorders for FSD1 gene to outside databases
|
Publications
for FSD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FSD1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FSD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. (PubMed id 11267680)1, 2, 3 Carim-Todd L.... Sumoy L. (2001)
- A novel centrosome-associated protein with affinity for microtubules. (PubMed id 12154070)1, 2, 9 Stein P.A....Rapoport T.A. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP- screening strategy. (PubMed id 12445389)1, 2 Manabe R.... Horwitz A.R. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
|
External Searches for FSD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FSD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FSD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FSD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FSD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FSD1 gene:
Search GeneIP for patents involving FSD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FSD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FSD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSD1 |
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| |  |  |  |  | | | | |
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 | | | FSD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSD1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSD1 |
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