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Aliases for FSD1 Gene

Aliases for FSD1 Gene

  • Fibronectin Type III And SPRY Domain Containing 1 2 3
  • GLFND 3 4 6
  • Fibronectin Type 3 And SPRY Domain Containing 1 2 3
  • Microtubule-Associated Protein GLFND 3 4
  • MID1-Related Protein 1 3 4
  • MIR1 3 4
  • Fibronectin Type 3 And SPRY (Spla, Ryanodine) Domain Containing (With Coiled-Coil Motif) 1 3
  • Fibronectin Type III And SPRY Domain-Containing Protein 1 3
  • Midline 1-Related Protein 1 3

External Ids for FSD1 Gene

Summaries for FSD1 Gene

Entrez Gene Summary for FSD1 Gene

  • This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009]

GeneCards Summary for FSD1 Gene

FSD1 (Fibronectin Type III And SPRY Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for FSD1 Gene

  • May be involved in microtubule organization and stabilization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSD1 Gene

Genomics for FSD1 Gene

Genomic Location for FSD1 Gene

Start:
4,304,594 bp from pter
End:
4,323,846 bp from pter
Size:
19,253 bases
Orientation:
Plus strand

Genomic View for FSD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSD1 Gene

Proteins for FSD1 Gene

  • Protein details for FSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTV5-FSD1_HUMAN
    Recommended name:
    Fibronectin type III and SPRY domain-containing protein 1
    Protein Accession:
    Q9BTV5
    Secondary Accessions:
    • B2RDT0
    • Q9BXN0
    • Q9HAG4

    Protein attributes for FSD1 Gene

    Size:
    496 amino acids
    Molecular mass:
    55820 Da
    Quaternary structure:
    • Oligomerization is required for binding to microtubules

neXtProt entry for FSD1 Gene

Proteomics data for FSD1 Gene at MOPED

Post-translational modifications for FSD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys13

Other Protein References for FSD1 Gene

No data available for DME Specific Peptides for FSD1 Gene

Domains for FSD1 Gene

Gene Families for FSD1 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing

Protein Domains for FSD1 Gene

UniProtKB/Swiss-Prot:

FSD1_HUMAN
Domain:
  • B30.2 box contains a microtubule-binding site:
    • Q9BTV5
  • Contains 1 B30.2/SPRY domain.:
    • Q9BTV5
  • Contains 1 COS domain.:
    • Q9BTV5
  • Contains 1 fibronectin type-III domain.:
    • Q9BTV5
genes like me logo Genes that share domains with FSD1: view

Function for FSD1 Gene

Molecular function for FSD1 Gene

UniProtKB/Swiss-Prot Function: May be involved in microtubule organization and stabilization.

Gene Ontology (GO) - Molecular Function for FSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FSD1: view

Phenotypes for FSD1 Gene

GenomeRNAi human phenotypes for FSD1:
genes like me logo Genes that share phenotypes with FSD1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FSD1 Gene

Localization for FSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Cleavage furrow. Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSD1 Gene COMPARTMENTS Subcellular localization image for FSD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for FSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with FSD1: view

Pathways for FSD1 Gene

SuperPathways for FSD1 Gene

No Data Available

Interacting Proteins for FSD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000221856%0d%0a9606.ENSP00000419782%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9BTV5-FSD1_HUMAN ENSP00000221856 for FSD1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for FSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FSD1: view

No data available for Pathways by source for FSD1 Gene

Transcripts for FSD1 Gene

Unigene Clusters for FSD1 Gene

Fibronectin type III and SPRY domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b
SP1:
SP2: -
SP3: -

Relevant External Links for FSD1 Gene

GeneLoc Exon Structure for
FSD1
ECgene alternative splicing isoforms for
FSD1

Expression for FSD1 Gene

mRNA expression in normal human tissues for FSD1 Gene

mRNA differential expression in normal tissues according to GTEx for FSD1 Gene

This gene is overexpressed in Brain - Cortex (6.4), Brain - Frontal Cortex (BA9) (5.4), Brain - Anterior cingulate cortex (BA24) (4.6), Brain - Hippocampus (4.4), Brain - Cerebellum (4.1), and Brain - Cerebellar Hemisphere (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FSD1 Gene

SOURCE GeneReport for Unigene cluster for FSD1 Gene Hs.28144

mRNA Expression by UniProt/SwissProt for FSD1 Gene

Q9BTV5-FSD1_HUMAN
Tissue specificity: Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord.
genes like me logo Genes that share expressions with FSD1: view

Orthologs for FSD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSD1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FSD1 36
  • 91.33 (n)
  • 95.77 (a)
FSD1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FSD1 36
  • 91.6 (n)
  • 96.37 (a)
FSD1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fsd1 36
  • 86.83 (n)
  • 93.15 (a)
Fsd1 16
Fsd1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FSD1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSD1 37
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FSD1 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fsd1 36
  • 69.15 (n)
  • 75 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16576 36
fsd1 36
  • 67.41 (n)
  • 69.11 (a)
fsd1 37
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Trim9 37
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 37
  • 13 (a)
OneToMany
Species with no ortholog for FSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FSD1 Gene

ENSEMBL:
Gene Tree for FSD1 (if available)
TreeFam:
Gene Tree for FSD1 (if available)

Paralogs for FSD1 Gene

Selected SIMAP similar genes for FSD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FSD1: view

Variants for FSD1 Gene

Sequence variations from dbSNP and Humsavar for FSD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3745988 -- 4,310,758(+) GGAGT(C/T)CTCAT intron-variant
rs3745989 -- 4,312,106(+) CCAGC(A/C)TCCCG intron-variant
rs3745990 -- 4,318,368(+) GATGC(A/G)TCCAC synonymous-codon, reference, nc-transcript-variant
rs3745991 -- 4,318,658(+) AGTGG(A/G/T)GTTTT intron-variant
rs3833275 -- 4,318,614(+) CTGGT(-/T)GGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSD1 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833717 CNV Loss 17160897
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
dgv3675n71 CNV Loss 21882294
nsv910824 CNV Gain 21882294
nsv458328 CNV Gain 19166990
esv1106527 CNV Insertion 17803354

Relevant External Links for FSD1 Gene

HapMap Linkage Disequilibrium report
FSD1

Disorders for FSD1 Gene

No disorders were found for FSD1 Gene.

No data available for UniProtKB/Swiss-Prot for FSD1 Gene

Publications for FSD1 Gene

  1. A novel centrosome-associated protein with affinity for microtubules. (PMID: 12154070) Stein P.A. … Rapoport T.A. (J. Cell Sci. 2002) 3 4 23
  2. Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. (PMID: 11267680) Carim-Todd L. … Sumoy L. (Biochim. Biophys. Acta 2001) 2 3 4
  3. Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP- screening strategy. (PMID: 12445389) Manabe R. … Horwitz A.R. (Curr. Biol. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for FSD1 Gene

Sources for FSD1 Gene

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