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Aliases for FSD1 Gene

Aliases for FSD1 Gene

  • Fibronectin Type III And SPRY Domain Containing 1 2 3 5
  • Fibronectin Type 3 And SPRY Domain Containing 1 2 3
  • Microtubule-Associated Protein GLFND 3 4
  • MID1-Related Protein 1 3 4
  • GLFND 3 4
  • MIR1 3 4
  • Fibronectin Type 3 And SPRY (Spla, Ryanodine) Domain Containing (With Coiled-Coil Motif) 1 3
  • Fibronectin Type III And SPRY Domain-Containing Protein 1 3
  • Midline 1-Related Protein 1 3

External Ids for FSD1 Gene

Previous GeneCards Identifiers for FSD1 Gene

  • GC19P004397
  • GC19P004244
  • GC19P004255
  • GC19P004068

Summaries for FSD1 Gene

Entrez Gene Summary for FSD1 Gene

  • This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009]

GeneCards Summary for FSD1 Gene

FSD1 (Fibronectin Type III And SPRY Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is FSD1L.

UniProtKB/Swiss-Prot for FSD1 Gene

  • May be involved in microtubule organization and stabilization.

Additional gene information for FSD1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSD1 Gene

Genomics for FSD1 Gene

GeneHancer (GH) Regulatory Elements for FSD1 Gene

Promoters and enhancers for FSD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I004300 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -1.7 -1720 4.5 RB1 ZNF493 ZNF76 SIN3A ETS1 ZNF335 ZNF121 ZNF143 CREM THAP11 TMIGD2 FSD1 ENSG00000267205 STAP2
GH19I004340 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.4 +37.8 37849 3.5 HDGF FOXA2 PKNOX1 CLOCK MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 STAP2 MPND SH3GL1 ENSG00000267255 FSD1 TMIGD2 SHD CHAF1A CCDC94 ENSG00000269425
GH19I003719 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 9.9 -583.5 -583501 4.8 HDGF PKNOX1 ARNT NEUROD1 SIN3A ZNF2 YY1 ZNF766 E2F8 ZNF207 GC19P003720 TJP3 ZNF77 CACTIN ZNF555 TLE2 MRPL54 GNA11 ZNF554 HDGFL2
GH19I004367 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +70.2 70226 14.8 MLX DMAP1 IRF4 E2F8 ZNF143 MEF2D SSRP1 GLIS1 RCOR2 NBN ENSG00000267769 SEMA6B CHAF1A CACTIN SH3GL1 UBXN6 CCDC94 CACTIN-AS1 ENSG00000267030 TMIGD2
GH19I004142 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.7 -158.0 -158020 8 PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 CACTIN APBA3 ENSG00000267769 CCDC94 ENSG00000267030 ENSG00000269807 CHAF1A ANKRD24 SIRT6 DPP9-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FSD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FSD1 gene promoter:

Genomic Locations for FSD1 Gene

Genomic Locations for FSD1 Gene
chr19:4,304,594-4,323,846
(GRCh38/hg38)
Size:
19,253 bases
Orientation:
Plus strand
chr19:4,304,591-4,323,843
(GRCh37/hg19)

Genomic View for FSD1 Gene

Genes around FSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSD1 Gene

Proteins for FSD1 Gene

  • Protein details for FSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTV5-FSD1_HUMAN
    Recommended name:
    Fibronectin type III and SPRY domain-containing protein 1
    Protein Accession:
    Q9BTV5
    Secondary Accessions:
    • B2RDT0
    • Q9BXN0
    • Q9HAG4

    Protein attributes for FSD1 Gene

    Size:
    496 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    • Oligomerization is required for binding to microtubules.

neXtProt entry for FSD1 Gene

Post-translational modifications for FSD1 Gene

Other Protein References for FSD1 Gene

No data available for DME Specific Peptides for FSD1 Gene

Domains & Families for FSD1 Gene

Gene Families for FSD1 Gene

Protein Domains for FSD1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSD1: view

No data available for UniProtKB/Swiss-Prot for FSD1 Gene

Function for FSD1 Gene

Molecular function for FSD1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in microtubule organization and stabilization.

Phenotypes From GWAS Catalog for FSD1 Gene

Gene Ontology (GO) - Molecular Function for FSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IMP 12154070
GO:0042803 protein homodimerization activity IMP 12154070
genes like me logo Genes that share ontologies with FSD1: view

Phenotypes for FSD1 Gene

GenomeRNAi human phenotypes for FSD1:
genes like me logo Genes that share phenotypes with FSD1: view

miRNA for FSD1 Gene

miRTarBase miRNAs that target FSD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSD1 Gene

Localization for FSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Cleavage furrow. Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for FSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IMP 12154070
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FSD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FSD1 Gene

Pathways & Interactions for FSD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0031122 cytoplasmic microtubule organization IMP 12154070
GO:0032465 regulation of cytokinesis IDA 12445389
GO:0051260 protein homooligomerization IMP 12154070
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FSD1: view

No data available for Pathways by source and SIGNOR curated interactions for FSD1 Gene

Drugs & Compounds for FSD1 Gene

No Compound Related Data Available

Transcripts for FSD1 Gene

Unigene Clusters for FSD1 Gene

Fibronectin type III and SPRY domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b
SP1:
SP2: -
SP3: -

Relevant External Links for FSD1 Gene

GeneLoc Exon Structure for
FSD1
ECgene alternative splicing isoforms for
FSD1

Expression for FSD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSD1 Gene

mRNA differential expression in normal tissues according to GTEx for FSD1 Gene

This gene is overexpressed in Brain - Cortex (x6.4), Brain - Frontal Cortex (BA9) (x5.4), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Hippocampus (x4.4), Brain - Cerebellum (x4.1), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for FSD1 Gene

This gene is overexpressed in Fetal Brain (33.2), Testis (15.9), and Frontal cortex (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FSD1 Gene



Protein tissue co-expression partners for FSD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FSD1 Gene:

FSD1

SOURCE GeneReport for Unigene cluster for FSD1 Gene:

Hs.28144

mRNA Expression by UniProt/SwissProt for FSD1 Gene:

Q9BTV5-FSD1_HUMAN
Tissue specificity: Highly expressed in brain tissues, including c.

Evidence on tissue expression from TISSUES for FSD1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with FSD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSD1 Gene

Orthologs for FSD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSD1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FSD1 33 34
  • 91.6 (n)
cow
(Bos Taurus)
Mammalia FSD1 33 34
  • 91.33 (n)
oppossum
(Monodelphis domestica)
Mammalia FSD1 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fsd1 33 16 34
  • 86.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FSD1 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FSD1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fsd1 33
  • 69.15 (n)
zebrafish
(Danio rerio)
Actinopterygii fsd1 33 34
  • 67.41 (n)
Dr.16576 33
fruit fly
(Drosophila melanogaster)
Insecta Trim9 34
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 34
  • 13 (a)
OneToMany
Species where no ortholog for FSD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FSD1 Gene

ENSEMBL:
Gene Tree for FSD1 (if available)
TreeFam:
Gene Tree for FSD1 (if available)

Paralogs for FSD1 Gene

Paralogs for FSD1 Gene

(2) SIMAP similar genes for FSD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FSD1: view

Variants for FSD1 Gene

Sequence variations from dbSNP and Humsavar for FSD1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000028241 -- 4,308,891(+) C/T intron_variant
rs1000035569 -- 4,306,916(+) G/A intron_variant
rs1000199429 -- 4,309,186(+) T/C intron_variant
rs1000303847 -- 4,314,576(+) T/C intron_variant
rs1000474710 -- 4,310,256(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FSD1 Gene

Variant ID Type Subtype PubMed ID
esv1106527 CNV insertion 17803354
nsv1119469 CNV insertion 24896259
nsv1144859 CNV deletion 24896259
nsv458328 CNV gain 19166990
nsv578442 CNV loss 21841781
nsv578443 CNV gain 21841781
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897

Variation tolerance for FSD1 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FSD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSD1 Gene

Disorders for FSD1 Gene

Additional Disease Information for FSD1

No disorders were found for FSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSD1 Gene

Publications for FSD1 Gene

  1. A novel centrosome-associated protein with affinity for microtubules. (PMID: 12154070) Stein PA … Rapoport TA (Journal of cell science 2002) 3 4 22 58
  2. Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. (PMID: 11267680) Carim-Todd L … Sumoy L (Biochimica et biophysica acta 2001) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy. (PMID: 12445389) Manabe Ri … Horwitz AR (Current biology : CB 2002) 3 4 58
  5. Regulation of microRNA-1 (miR-1) expression in human cancer. (PMID: 27923712) Han C … Duan Z (Biochimica et biophysica acta 2017) 3 58

Products for FSD1 Gene

Sources for FSD1 Gene

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