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Aliases for FSCN3 Gene

Aliases for FSCN3 Gene

  • Fascin Actin-Bundling Protein 3 2 3 5
  • Fascin Actin-Bundling Protein 3, Testicular 2 3
  • Testis Fascin 3 4
  • Fascin (Strongylocentrotus Purpuratus) Homolog 3 (Actin-Bundling Protein, Testicular) 2
  • Fascin Homolog 3, Actin-Bundling Protein, Testicular (Strongylocentrotus Purpuratus) 2
  • Fascin Homolog 3, Actin-Bundling Protein, Testicular 3
  • Testicular Secretory Protein Li 18 3
  • Fascin-3 3

External Ids for FSCN3 Gene

Previous GeneCards Identifiers for FSCN3 Gene

  • GC07P125711
  • GC07P126774
  • GC07P126788
  • GC07P126827
  • GC07P127020
  • GC07P127232
  • GC07P121594

Summaries for FSCN3 Gene

GeneCards Summary for FSCN3 Gene

FSCN3 (Fascin Actin-Bundling Protein 3) is a Protein Coding gene. Diseases associated with FSCN3 include Hodgkin's Lymphoma, Lymphocytic Depletion and Colloid Carcinoma Of The Pancreas. Among its related pathways are MAPK-Erk Pathway. GO annotations related to this gene include actin filament binding and protein binding, bridging. An important paralog of this gene is FSCN1.

UniProtKB/Swiss-Prot for FSCN3 Gene

  • Acts as an actin bundling protein.

Gene Wiki entry for FSCN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSCN3 Gene

Genomics for FSCN3 Gene

Regulatory Elements for FSCN3 Gene

Enhancers for FSCN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F128061 0.6 FANTOM5 43.4 +470.1 470124 0.1 FSCN3 SND1 LRRC4 GC07P128061 GC07P128085
GH07F127619 0.3 FANTOM5 20.5 +28.5 28505 0.4 HDGF MTA2 ZNF239 ZNF493 IKZF1 YBX1 ZNF785 FSCN3 GCC1 ENSG00000240790 SND1 PAX4
GH07F127673 0.5 Ensembl 14.4 +82.4 82393 0.8 ZNF263 TEAD4 NFXL1 ZNF645 ZNF366 IKZF1 PRDM1 ZBTB20 LOC100196944 LOC101928333 ENSG00000224981 FSCN3 FAM71F2 GC07P127653 GC07P127654 PIR48128
GH07F127391 0.4 ENCODE 14.3 -198.9 -198901 3.0 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF207 KLF13 ZNF800 LOC101928333 LOC100196944 ENSG00000224981 ENSG00000224138 FSCN3 GCC1 GC07M127372 GC07M127373
GH07F128166 1.1 FANTOM5 Ensembl ENCODE 14.2 +576.4 576360 2.7 GLI4 ZNF2 ZNF121 GLIS2 KLF7 ZNF263 SP3 NCOA1 MIER2 REST LOC100196944 ENSG00000242162 CYCSP20 LOC101928333 FSCN3 FAM71F2 LRRC4 LOC101928423 LOC105375493
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FSCN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FSCN3 Gene

Chromosome:
7
Start:
127,591,409 bp from pter
End:
127,602,144 bp from pter
Size:
10,736 bases
Orientation:
Plus strand

Genomic View for FSCN3 Gene

Genes around FSCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSCN3 Gene

Proteins for FSCN3 Gene

  • Protein details for FSCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQT6-FSCN3_HUMAN
    Recommended name:
    Fascin-3
    Protein Accession:
    Q9NQT6
    Secondary Accessions:
    • A4D0Z2
    • A6NLL7
    • B2RA62
    • B4DU68

    Protein attributes for FSCN3 Gene

    Size:
    498 amino acids
    Molecular mass:
    56624 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FSCN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSCN3 Gene

Post-translational modifications for FSCN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSCN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSCN3 Gene

Domains & Families for FSCN3 Gene

Gene Families for FSCN3 Gene

HGNC:

Protein Domains for FSCN3 Gene

Suggested Antigen Peptide Sequences for FSCN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQT6

UniProtKB/Swiss-Prot:

FSCN3_HUMAN :
  • Belongs to the fascin family.
Family:
  • Belongs to the fascin family.
genes like me logo Genes that share domains with FSCN3: view

Function for FSCN3 Gene

Molecular function for FSCN3 Gene

UniProtKB/Swiss-Prot Function:
Acts as an actin bundling protein.

Gene Ontology (GO) - Molecular Function for FSCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030674 protein binding, bridging IEA --
GO:0051015 actin filament binding IEA,IBA --
genes like me logo Genes that share ontologies with FSCN3: view
genes like me logo Genes that share phenotypes with FSCN3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FSCN3 Gene

Localization for FSCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSCN3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSCN3 Gene COMPARTMENTS Subcellular localization image for FSCN3 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for FSCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005856 cytoskeleton TAS 10783262
GO:0015629 actin cytoskeleton ISS --
GO:0031941 filamentous actin IBA --
genes like me logo Genes that share ontologies with FSCN3: view

Pathways & Interactions for FSCN3 Gene

SuperPathways for FSCN3 Gene

SuperPathway Contained pathways
1 MAPK-Erk Pathway
genes like me logo Genes that share pathways with FSCN3: view

Pathways by source for FSCN3 Gene

1 Sino Biological pathway for FSCN3 Gene

Interacting Proteins for FSCN3 Gene

Gene Ontology (GO) - Biological Process for FSCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0007286 spermatid development IEA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0016477 cell migration IBA --
genes like me logo Genes that share ontologies with FSCN3: view

No data available for SIGNOR curated interactions for FSCN3 Gene

Transcripts for FSCN3 Gene

Unigene Clusters for FSCN3 Gene

Fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSCN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2:

Relevant External Links for FSCN3 Gene

GeneLoc Exon Structure for
FSCN3
ECgene alternative splicing isoforms for
FSCN3

Expression for FSCN3 Gene

mRNA expression in normal human tissues for FSCN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSCN3 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for FSCN3 Gene

This gene is overexpressed in Testis (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSCN3 Gene



Protein tissue co-expression partners for FSCN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FSCN3 Gene:

FSCN3

SOURCE GeneReport for Unigene cluster for FSCN3 Gene:

Hs.712692

mRNA Expression by UniProt/SwissProt for FSCN3 Gene:

Q9NQT6-FSCN3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with FSCN3: view

Primer Products

Orthologs for FSCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSCN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSCN3 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia FSCN3 34 35
  • 85.38 (n)
cow
(Bos Taurus)
Mammalia FSCN3 34 35
  • 84.67 (n)
mouse
(Mus musculus)
Mammalia Fscn3 34 16 35
  • 83.53 (n)
rat
(Rattus norvegicus)
Mammalia Fscn3 34
  • 83.4 (n)
oppossum
(Monodelphis domestica)
Mammalia FSCN3 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSCN3 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FSCN3 35
  • 24 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-160d14.1 35
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta sn 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for FSCN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSCN3 Gene

ENSEMBL:
Gene Tree for FSCN3 (if available)
TreeFam:
Gene Tree for FSCN3 (if available)

Paralogs for FSCN3 Gene

Paralogs for FSCN3 Gene

genes like me logo Genes that share paralogs with FSCN3: view

Variants for FSCN3 Gene

Sequence variations from dbSNP and Humsavar for FSCN3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10685553 -- 127,594,105(+) TGTGT(-/GT)ATGTA intron-variant, upstream-variant-2KB
rs10808230 -- 127,592,147(+) GGCGC(A/G)GTGGC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs111310956 -- 127,594,197(+) GTGTG(C/T)ACTTG intron-variant, upstream-variant-2KB
rs111337089 -- 127,596,193(+) CTAGG(A/T)CTTCT intron-variant
rs111384868 -- 127,594,512(+) TGTCA(C/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSCN3 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV gain 17160897

Variation tolerance for FSCN3 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.33; 81.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSCN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSCN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSCN3 Gene

Disorders for FSCN3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FSCN3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hodgkin's lymphoma, lymphocytic depletion
  • hodgkin lymphoma, lymphocyte depletion
colloid carcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards
Search FSCN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FSCN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSCN3
genes like me logo Genes that share disorders with FSCN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FSCN3 Gene

Publications for FSCN3 Gene

  1. Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. (PMID: 11925108) Tubb B. … Bryan J. (Exp. Cell Res. 2002) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F. … Reymond A. (Genome Res. 2007) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for FSCN3 Gene

Sources for FSCN3 Gene

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