Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FSCN3 Gene

Aliases for FSCN3 Gene

  • Fascin Actin-Bundling Protein 3 2 3 5
  • Fascin (Strongylocentrotus Purpuratus) Homolog 3 (Actin-Bundling Protein, Testicular) 2
  • Fascin Homolog 3, Actin-Bundling Protein, Testicular (Strongylocentrotus Purpuratus) 2
  • Fascin Actin-Bundling Protein 3, Testicular 2
  • Testis Fascin 4

External Ids for FSCN3 Gene

Previous GeneCards Identifiers for FSCN3 Gene

  • GC07P125711
  • GC07P126774
  • GC07P126788
  • GC07P126827
  • GC07P127020
  • GC07P127232
  • GC07P121594

Summaries for FSCN3 Gene

GeneCards Summary for FSCN3 Gene

FSCN3 (Fascin Actin-Bundling Protein 3) is a Protein Coding gene. GO annotations related to this gene include actin filament binding and protein binding, bridging. An important paralog of this gene is FSCN2.

UniProtKB/Swiss-Prot for FSCN3 Gene

  • Acts as an actin bundling protein.

Gene Wiki entry for FSCN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSCN3 Gene

Genomics for FSCN3 Gene

Regulatory Elements for FSCN3 Gene

Enhancers for FSCN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FSCN3 on UCSC Golden Path with GeneCards custom track

Promoters for FSCN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FSCN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FSCN3 Gene

Chromosome:
7
Start:
127,591,409 bp from pter
End:
127,602,144 bp from pter
Size:
10,736 bases
Orientation:
Plus strand

Genomic View for FSCN3 Gene

Genes around FSCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSCN3 Gene

Proteins for FSCN3 Gene

  • Protein details for FSCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQT6-FSCN3_HUMAN
    Recommended name:
    Fascin-3
    Protein Accession:
    Q9NQT6
    Secondary Accessions:
    • A4D0Z2
    • A6NLL7
    • B2RA62
    • B4DU68

    Protein attributes for FSCN3 Gene

    Size:
    498 amino acids
    Molecular mass:
    56624 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FSCN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSCN3 Gene

Proteomics data for FSCN3 Gene at MOPED

Post-translational modifications for FSCN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSCN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSCN3 Gene

Domains & Families for FSCN3 Gene

Gene Families for FSCN3 Gene

HGNC:

Protein Domains for FSCN3 Gene

Suggested Antigen Peptide Sequences for FSCN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQT6

UniProtKB/Swiss-Prot:

FSCN3_HUMAN :
  • Belongs to the fascin family.
Family:
  • Belongs to the fascin family.
genes like me logo Genes that share domains with FSCN3: view

Function for FSCN3 Gene

Molecular function for FSCN3 Gene

UniProtKB/Swiss-Prot Function:
Acts as an actin bundling protein.

Gene Ontology (GO) - Molecular Function for FSCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with FSCN3: view
genes like me logo Genes that share phenotypes with FSCN3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FSCN3 Gene

Localization for FSCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSCN3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSCN3 Gene COMPARTMENTS Subcellular localization image for FSCN3 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for FSCN3 Gene

Pathways & Interactions for FSCN3 Gene

SuperPathways for FSCN3 Gene

No Data Available

Interacting Proteins for FSCN3 Gene

Gene Ontology (GO) - Biological Process for FSCN3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FSCN3 Gene

Drugs & Compounds for FSCN3 Gene

No Compound Related Data Available

Transcripts for FSCN3 Gene

Unigene Clusters for FSCN3 Gene

Fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSCN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2:

Relevant External Links for FSCN3 Gene

GeneLoc Exon Structure for
FSCN3
ECgene alternative splicing isoforms for
FSCN3

Expression for FSCN3 Gene

mRNA expression in normal human tissues for FSCN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSCN3 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for FSCN3 Gene

This gene is overexpressed in Testis (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSCN3 Gene



SOURCE GeneReport for Unigene cluster for FSCN3 Gene Hs.712692

mRNA Expression by UniProt/SwissProt for FSCN3 Gene

Q9NQT6-FSCN3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with FSCN3: view

Protein tissue co-expression partners for FSCN3 Gene

- Elite partner

Primer Products

Orthologs for FSCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSCN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FSCN3 35
  • 84.67 (n)
  • 83.13 (a)
FSCN3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FSCN3 35
  • 85.38 (n)
  • 82.49 (a)
FSCN3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fscn3 35
  • 83.53 (n)
  • 84.54 (a)
Fscn3 16
Fscn3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FSCN3 35
  • 99.46 (n)
  • 99.2 (a)
FSCN3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fscn3 35
  • 83.4 (n)
  • 83.33 (a)
oppossum
(Monodelphis domestica)
Mammalia FSCN3 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSCN3 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FSCN3 36
  • 24 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-160d14.1 36
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta sn 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for FSCN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSCN3 Gene

ENSEMBL:
Gene Tree for FSCN3 (if available)
TreeFam:
Gene Tree for FSCN3 (if available)

Paralogs for FSCN3 Gene

Paralogs for FSCN3 Gene

genes like me logo Genes that share paralogs with FSCN3: view

Variants for FSCN3 Gene

Sequence variations from dbSNP and Humsavar for FSCN3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_022021 -
rs34394613 - 127,599,543(+) CTACC(A/T)CTTCC reference, missense
rs806213 -- 127,594,936(+) CTCTG(A/C/T)GGACA intron-variant
rs806214 -- 127,596,949(+) ttagc(A/G)tttct intron-variant
rs806215 -- 127,597,258(+) taggt(C/T)gtata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSCN3 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV Gain 17160897

Variation tolerance for FSCN3 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.33; 81.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FSCN3 Gene

Disorders for FSCN3 Gene

Relevant External Links for FSCN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSCN3

No disorders were found for FSCN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSCN3 Gene

Publications for FSCN3 Gene

  1. Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. (PMID: 11925108) Tubb B. … Bryan J. (Exp. Cell Res. 2002) 2 3 4 23 67
  2. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F. … Reymond A. (Genome Res. 2007) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FSCN3 Gene

Sources for FSCN3 Gene

Content