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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FSCN3 Gene

protein-coding   GIFtS: 45
GCID: GC07P127232

Fascin Homolog 3, Actin-Bundling Protein, Testicular (Strongylocentrotus...

(Previous names: fascin (Strongylocentrotus purpuratus) homolog 3 (actin-bundling...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fascin Homolog 3, Actin-Bundling Protein, Testicular
(Strongylocentrotus Purpuratus)1 2
Testis Fascin2 3
Fascin (Strongylocentrotus Purpuratus) Homolog 3 (Actin-Bundling Protein,
Testicular)1
fascin-32

External Ids:    HGNC: 39611   Entrez Gene: 299992   Ensembl: ENSG000001063287   UniProtKB: Q9NQT63   

Export aliases for FSCN3 gene to outside databases

Previous GC identifers: GC07P125711 GC07P126774 GC07P126788 GC07P126827 GC07P127020 GC07P121594


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FSCN3 Gene: 
FSCN3 (fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)) is a protein-coding gene. Diseases associated with FSCN3 include dandy-walker syndrome, and pancreas adenocarcinoma. GO annotations related to this gene include actin filament binding and protein binding, bridging. An important paralog of this gene is FSCN2.

UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6
Function: Acts as an actin bundling protein (By similarity)

Gene Wiki entry for FSCN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FSCN3 gene promoter:
         AP-1   GATA-3   ATF-2   USF-1:USF-2   Nkx2-5   E47   USF-1   Hand1   Chx10   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSCN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FSCN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSCN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q31.3

FSCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSCN3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P127232:  view genomic region     (about GC identifiers)

Start:
127,231,463 bp from pter      End:
127,242,198 bp from pter
Size:
10,736 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 126,617,134-126,625,289     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6 (See protein sequence)
Recommended Name: Fascin-3  
Size: 498 amino acids; 56624 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: A4D0Z2 A6NLL7 B2RA62

Explore the universe of human proteins at neXtProt for FSCN3: NX_Q9NQT6

Explore proteomics data for FSCN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQT6

  • FSCN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FSCN3 Protein Expression
    REFSEQ proteins: NP_065102.1  
    ENSEMBL proteins: 
     ENSP00000265825   ENSP00000473531   ENSP00000402472   ENSP00000412243  

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    Novus Biologicals FSCN3 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FSCN3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton TAS10783262
    GO:0015629actin cytoskeleton ISS--

    FSCN3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR010431 Fascin
     IPR022768 Fascin-domain
     IPR024703 Fascin_metazoans
     IPR008999 Actin_cross-linking

    Graphical View of Domain Structure for InterPro Entry Q9NQT6

    ProtoNet protein and cluster: Q9NQT6

    UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6
    Similarity: Belongs to the fascin family


    FSCN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSCN3_HUMAN, Q9NQT6
    Function: Acts as an actin bundling protein (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030674protein binding, bridging IEA--
    GO:0051015actin filament binding IEA--
         
    FSCN3 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FSCN3 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFSCN3 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSCN3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FSCN3

    Search CenterWatch for drugs/clinical trials and news about FSCN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FSCN3 gene: 
    NM_020369.2  

    Unigene Cluster for FSCN3:

    Fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
    Hs.712692  [show with all ESTs]
    Unigene Representative Sequence: NM_020369
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478328(uc003vmc.1) ENST00000265825(uc003vmd.2 uc010llc.2)
    ENST00000478821 ENST00000421705 ENST00000469242 ENST00000420086(uc011kog.1 uc011koh.1)

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate FSCN3 (see all 11):
    hsa-miR-3132 hsa-miR-4254 hsa-miR-19b-2* hsa-miR-3171 hsa-miR-382 hsa-miR-548g hsa-miR-19b-1* hsa-miR-19a*
    SwitchGear 3'UTR luciferase reporter plasmidFSCN3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF281049.1 AK225867.1 AK300518.1 AK301765.1 AK314050.1 BC035606.1 DQ655929.2 DQ655930.2 

    4 DOTS entries:

    DT.40127429  DT.121066991  DT.100706330  DT.91665288 

    24/446 AceView cDNA sequences (see all 446):

    CR592940 AI359961 AL560575 BI916808 BQ877727 BE613454 AA300825 BQ877722 
    BM873852 BQ668461 BU070721 BU157900 CD108092 BE905963 BQ671954 CD672848 
    CB856881 AI367505 BU145336 CD676372 BC035606 BU154945 CR624513 BM701701 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FSCN3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:              -     -                                             
    SP2:                                                                  


    ECgene alternative splicing isoforms for FSCN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FSCN3 expression in normal human tissues (normalized intensities)      FSCN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAGCCGACC
    FSCN3 Expression
    About this image


    FSCN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
             sperm   

    See FSCN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FSCN3

    SOURCE GeneReport for Unigene cluster: Hs.712692

    UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6
    Tissue specificity: Expressed in testis

        SABiosciences Custom PCR Arrays for FSCN3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FSCN3 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fscn31 , 5 fascin homolog 3, actin-bundling protein, testicular more1, 5 83.53(n)1
    84.54(a)1
      6 (11.99 cM)5
    562231  NM_019569.21  NP_062515.21 
     284277895 
    lizard
    (Anolis carolinensis)
    Reptilia FSCN36
    Fascin
    24(a)
    1 ↔ 1
    GL343235.1(856889-870945)
    fruit fly
    (Drosophila melanogaster)
    Insecta sn6
    singed
    23(a)
    1 → many
    X(7858057-7880118)


    ENSEMBL Gene Tree for FSCN3 (if available)
    TreeFam Gene Tree for FSCN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FSCN3 gene
    FSCN22  FSCN12  

    FSCN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/295 SNPs in FSCN3 are shown (see all 295)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs677196491,2
    C--127232264(+) TCAGAG/AGATCG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs346931501,2
    C--127232299(+) ACTAG-/AAAAAA 1 -- us2k12Minor allele frequency- A:0.25NA CSA 4
    rs1845137861,2
    --127232323(+) ATTATC/TCAGGC 1 -- us2k10--------
    rs1893997211,2
    --127232462(+) GACTCC/TGTCTC 1 -- us2k10--------
    rs1508770461,2
    --127232584(+) CCTTGC/TTGCAC 1 -- us2k10--------
    rs1144970181,2
    C,F--127232656(+) AGGAAC/GCACGG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs77867391,2
    C,F,H--127232660(+) ACCACG/AGGTgg 1 -- us2k15Minor allele frequency- A:0.00NS EA WA 498
    rs1822315401,2
    --127232751(+) GACCAA/GCCTGG 1 -- us2k10--------
    rs1391140401,2
    C--127232803(+) AAAATC/TACCTG 1 -- us2k10--------
    rs752138161,2
    C,F--127232906(+) AGATGC/TACTCC 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for FSCN3 (127231463 - 127242198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FSCN3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831122CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    7 diseases for FSCN3:    About MalaCards
    dandy-walker syndrome    pancreas adenocarcinoma    dendritic cell sarcoma    histiocytosis
    sarcoma    retinitis    adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for FSCN3:
    Histiocytosis     Carcinoma     Dendritic cell sarcoma

    FSCN3 for disorders           About GeneDecksing


    Export disorders for FSCN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FSCN3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FSCN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. (PubMed id 11925108)1, 2, 3, 9 Tubb B.... Bryan J. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PubMed id 10783262)1 Tubb B.E.... Bryan J. (2000)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29999 HGNC: 3961 AceView: ARF5andFSCN3 Ensembl:ENSG00000106328 euGenes: HUgn29999
    ECgene: FSCN3 H-InvDB: FSCN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FSCN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FSCN3 gene:
    Search GeneIP for patents involving FSCN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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