FSCN3 Gene
protein-coding GIFtS: 43
GCID: GC07P127232
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fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus...(Previous names: fascin (Strongylocentrotus purpuratus) homolog 3 (actin-bundling...)
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Aliases
for FSCN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fascin Homolog 3, Actin-Bundling Protein, Testicular (StrongylocentrotusPurpuratus)1 2 | | Testis Fascin2 3 | | Fascin (Strongylocentrotus Purpuratus) Homolog 3 (Actin-Bundling Protein,Testicular)1 | | Fascin-31 |
Export aliases for FSCN3 gene to outside databasesPrevious GC identifers: GC07P125711 GC07P126774 GC07P126788 GC07P126827 GC07P127020 GC07P121594 |
Summaries
for FSCN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6Function: Acts as an actin bundling protein (By similarity)
Gene Wiki entry for FSCN3
|
Genomic Views
for FSCN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FSCN3 gene promoter:
AP-1 GATA-3 ATF-2 USF-1:USF-2 Nkx2-5 E47 USF-1 Hand1 Chx10 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for FSCN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSCN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.3 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q31.3FSCN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P127232: view genomic region
(about GC identifiers)
Start:
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127,231,463 bp from pter |
End:
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127,242,198 bp from pter |
Size:
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10,736 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 126,617,134-126,625,281 |
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Proteins
for FSCN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6 (See
protein sequence)Recommended Name: Fascin-3 Size: 498 amino acids; 56624 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: A4D0Z2 A6NLL7 B2RA62Explore the universe of human proteins at neXtProt for FSCN3: NX_Q9NQT6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQT6
FSCN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065102.1
ENSEMBL proteins: ENSP00000265825 ENSP00000402472 ENSP00000412243
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FSCN3 for ontologies About GeneDecksing
FSCN3 Antibody Products:
Assay Products for FSCN3: |
Protein
Domains /
Families
for FSCN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FSCN3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NQT6ProtoNet protein and cluster: Q9NQT6 UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6Similarity: Belongs to the fascin family |
Function
for FSCN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6Function: Acts as an actin bundling protein (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSCN3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSCN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FSCN3 (NM_020369) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FSCN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCN3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030674 | protein binding, bridging |
IEA | -- | | GO:0051015 | actin filament binding |
IEA | -- |
FSCN3 for ontologies About GeneDecksing
|
Pathways & Interactions
for FSCN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSCN3
|
Drugs & Compounds
for FSCN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FSCN3
Search CenterWatch for drugs/clinical trials and news about FSCN3
|
Transcripts
for FSCN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FSCN3 gene: NM_020369.2 Unigene Cluster for FSCN3: Fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus) Hs.712692 [show with all ESTs]Unigene Representative Sequence: NM_0203696 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478328(uc003vmc.1) ENST00000265825(uc003vmd.2 uc010llc.2)
ENST00000478821 ENST00000421705 ENST00000469242 ENST00000420086(uc011kog.1 uc011koh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSCN3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSCN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FSCN3 (NM_020369) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FSCN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCN3 |
Additional cDNA sequence: AF281049.1 AK225867.1 AK300518.1 AK301765.1 AK314050.1 BC035606.1 DQ655929.2 DQ655930.2 4 DOTS entries: DT.40127429 DT.121066991 DT.100706330 DT.91665288 24/446 AceView cDNA sequences (see all 446): NM_001662 BQ675321 BM738422 CR625466 BQ276442 BC033104 CR619680 CD676372 BE888172 BU154945 CR592940 BQ877722 BM760643 BQ083803 AI659642 BM762369 CD108092 CR619021 CA454689 BX331804 BG751396 BQ687628 CR624558 CR618126
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FSCN3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FSCN3
|
Expression
for FSCN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FSCN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGAGCCGACC
About this image
See FSCN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FSCN3
SOURCE GeneReport for Unigene cluster: Hs.712692
UniProtKB/Swiss-Prot: FSCN3_HUMAN, Q9NQT6Tissue specificity: Expressed in testis
SABiosciences Custom PCR Arrays for FSCN3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSCN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FSCN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSCN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSCN3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN3 |
Orthologs
for FSCN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FSCN3 gene from 2/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
FSCN36 |
-- |
25(a) |
1 ↔ 1 |
GL343235.1(856943-870919) |
fruit fly
(Drosophila melanogaster) |
Insecta |
sn6 |
singed |
22(a) |
1 → many |
X(7858057-7880118) |
ENSEMBL Gene Tree for FSCN3 (if available)
TreeFam Gene Tree for FSCN3 (if available) |
Paralogs
for FSCN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FSCN3 gene
- FSCN22 FSCN12
FSCN3 for paralogs About GeneDecksing
|
Genomic Variants
for FSCN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FSCN3 (127231463 - 127242198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FSCN3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSCN3 |
|
Disorders
/ Diseases
for FSCN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FSCN3 for disorders About GeneDecksing
7  diseases for FSCN3: About MalaCardsdandy-walker syndrome dendritic cell sarcoma pancreas adenocarcinoma histiocytosis
sarcoma retinitis adenocarcinoma
3 diseases from the University of Copenhagen DISEASES database for FSCN3:Histiocytosis Carcinoma Dendritic cell sarcoma Export disorders for FSCN3 gene to outside databases
|
Publications
for FSCN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FSCN3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FSCN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. (PubMed id 11925108)1, 2, 3, 9 Tubb B.... Bryan J. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PubMed id 10783262)1 Tubb B.E.... Bryan J. (2000)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for FSCN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FSCN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FSCN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FSCN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FSCN3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FSCN3 gene:
Search GeneIP for patents involving FSCN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FSCN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FSCN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FSCN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSCN3 | | | OriGene Protein Over-expression Lysate for FSCN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FSCN3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSCN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSCN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FSCN3 | | OriGene Custom Protein Services for FSCN3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FSCN3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSCN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSCN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSCN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSCN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSCN3 |
| |
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| |  |  |  |  | | | | |
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 |
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 | | | FSCN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN3 |
|  |  |  | | | | Search ThermoFisher Antibodies for FSCN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCN3 |
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