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FSCN2 Gene

protein-coding   GIFtS: 52
GCID: GC17P079495

Fascin Actin-Bundling Protein 2, Retinal

(Previous names: fascin (Strongylocentrotus purpuratus) homolog 2 (actin-bundling...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fascin Actin-Bundling Protein 2, Retinal1 2     Fascin Homolog 2, Actin-Bundling Protein, Retinal (Strongylocentrotus
Purpuratus)1
RFSN2 5     Fascin Homolog 2, Actin-Bundling Protein, Retinal2
RP302 5     fascin-22
Fascin (Strongylocentrotus Purpuratus) Homolog 2 (Actin-Bundling Protein,
Retinal)1
     Retinal Fascin3

External Ids:    HGNC: 39601   Entrez Gene: 257942   Ensembl: ENSG000001867657   OMIM: 6076435   UniProtKB: O149263   

Export aliases for FSCN2 gene to outside databases

Previous GC identifers: GC17U990164 GC17M080035 GC17P080195 GC17P077110 GC17P074944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FSCN2 Gene:
This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within
dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A
mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for FSCN2 Gene:
FSCN2 (fascin actin-bundling protein 2, retinal) is a protein-coding gene. Diseases associated with FSCN2 include retinitis pigmentosa 30, and fscn2-related retinitis pigmentosa. GO annotations related to this gene include actin binding and protein binding, bridging. An important paralog of this gene is FSCN3.

UniProtKB/Swiss-Prot: FSCN2_HUMAN, O14926
Function: Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such
as disk morphogenesis

Gene Wiki entry for FSCN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FSCN2 gene promoter:
         p53   AP-4   Tal-1beta   E47   GATA-2   E2F   E2F-1   c-Myb   TGIF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSCN2 promoter sequence
   Search Chromatin IP Primers for FSCN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FSCN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

FSCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSCN2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079495:  view genomic region     (about GC identifiers)

Start:
79,495,417 bp from pter      End:
79,504,156 bp from pter
Size:
8,740 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FSCN2_HUMAN, O14926 (See protein sequence)
Recommended Name: Fascin-2  
Size: 492 amino acids; 55057 Da
Secondary accessions: A0AVC4 A8MRA6
Alternative splicing: 2 isoforms:  O14926-1   O14926-2   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for FSCN2: NX_O14926

Explore proteomics data for FSCN2 at MOPED


See FSCN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001070650.1  NP_036550.1  

ENSEMBL proteins: 
 ENSP00000388716   ENSP00000334665  

FSCN2 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for FSCN2

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Cloud-Clone Corp. CLIAs for FSCN2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FSCN: Fascins

4 InterPro protein domains:
 IPR010431 Fascin
 IPR022768 Fascin-domain
 IPR024703 Fascin_metazoans
 IPR008999 Actin_cross-linking

Graphical View of Domain Structure for InterPro Entry O14926

ProtoNet protein and cluster: O14926

UniProtKB/Swiss-Prot: FSCN2_HUMAN, O14926
Similarity: Belongs to the fascin family


FSCN2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FSCN2_HUMAN, O14926
Function: Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such
as disk morphogenesis

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003779actin binding ISS--
GO:0008083growth factor activity ----
GO:0030674protein binding, bridging IEA--
GO:0051015actin filament binding ISS--
     
FSCN2 for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fscn2):
 hearing/vestibular/ear  nervous system  vision/eye 

FSCN2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for FSCN2: Fscn2tm1Sykk Fscn2tm2Sykk

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FSCN2
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FSCN2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FSCN2

miRNA
Products:
    
miRTarBase miRNAs that target FSCN2:
hsa-mir-335-5p (MIRT019017), hsa-mir-16-5p (MIRT051107)

Block miRNA regulation of human, mouse, rat FSCN2 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate FSCN2
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Predesigned siRNA for gene silencing in human, mouse, rat FSCN2

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): FSCN2 (NM_012418)
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FSCN2_HUMAN, O14926: Cytoplasm, cytoskeleton (By similarity). Cell projection, stereocilium (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton4
cytosol3
nucleus2
extracellular1
peroxisome1
plasma membrane1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--
GO:0015629actin cytoskeleton ISS--
GO:0032420stereocilium IEA--

FSCN2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including FSCN2: 
          Cytoskeleton Regulators in human mouse rat

Interactions:

    GeneGlobe Interaction Network for FSCN2

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for FSCN2 (ENSP000003346654) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
AVILENSP000002578614STRING: ENSP00000257861
GSNENSP000003629244STRING: ENSP00000362924
SCINENSP000002970294STRING: ENSP00000297029
VIL1ENSP000002484444STRING: ENSP00000248444
PHC2ENSP000002571184STRING: ENSP00000257118
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007601visual perception TAS10783262
GO:0009653anatomical structure morphogenesis TAS10783262
GO:0030036actin cytoskeleton organization ISS--
GO:0042462eye photoreceptor cell development IEA--
GO:0051017actin filament bundle assembly TAS10783262

FSCN2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FSCN2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FSCN2 gene (2 alternative transcripts): 
NM_001077182.2  NM_012418.3  

Unigene Cluster for FSCN2:

Fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
Hs.118555  [show with all ESTs]
Unigene Representative Sequence: NM_001077182
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000417245(uc010wuo.2 uc010wup.2) ENST00000334850 ENST00000527221

miRNA
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Search for qRT-PCR Assays for microRNAs that regulate FSCN2
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat FSCN2
Clone
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OriGene ORF clones in mouse, rat for FSCN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): FSCN2 (NM_012418)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSCN2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCN2
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for FSCN2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FSCN2
  QuantiTect SYBR Green Assays in human, mouse, rat FSCN2
  QuantiFast Probe-based Assays in human, mouse, rat FSCN2

Additional mRNA sequence: 

AF030165.1 BC126295.1 BC130330.1 DQ426873.1 

2 DOTS entries:

DT.443550  DT.100741139 

17 AceView cDNA sequences:

BM932109 BM929819 BM709287 AF030165 NM_012418 AI189621 AA018553 AA046412 
BU732435 BQ186352 BQ185852 AA017631 AA058860 AA046878 AA018572 AA059324 
AI703219 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FSCN2    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:                              
SP2:                              


ECgene alternative splicing isoforms for FSCN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FSCN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTGAGATGG
FSCN2 Expression
About this image


FSCN2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Eye (Sensory Organs)
         Mature Rod Cells Outer Nuclear Layer
 
 Neurons
         Mature Rod Cells Outer Nuclear Layer
 
 Pancreas (Endocrine System)
FSCN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FSCN2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.118555

UniProtKB/Swiss-Prot: FSCN2_HUMAN, O14926
Tissue specificity: Localized specifically in the outer and inner segments of the photoreceptor cells in the
retina

    Pathway & Disease-focused RT2 Profiler PCR Array including FSCN2: 
          Cytoskeleton Regulators in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for FSCN2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FSCN2
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QuantiFast Probe-based Assays in human, mouse, rat FSCN2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for FSCN2 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fscn21 , 5 fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus more1, 5 85.84(n)1
90.85(a)1
  11 (84.08 cM)5
2380211  NM_172802.41  NP_766390.21 
 1203615345 
chicken
(Gallus gallus)
Aves FSCN21 fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus more 76.51(n)
70.47(a)
  429198  NM_001177738.1  NP_001171209.1 
lizard
(Anolis carolinensis)
Reptilia FSCN26
fascin homolog 2, actin-bundling protein, retinal ...
70(a)
1 ↔ 1
2(98633655-98659158)
African clawed frog
(Xenopus laevis)
Amphibia Xl.263332 Xenopus laevis transcribed sequence with weak similarity more 75.03(n)    CD328490.1 
zebrafish
(Danio rerio)
Actinopterygii zgc732722 hypothetical protein MGC73272 74.98(n)   393743  BC059601.1 
fruit fly
(Drosophila melanogaster)
Insecta sn1 , 3 actin filament organization actin
binding3
singed1
38(a)3
51.19(n)1
39.08(a)1
  317171  NM_001169225.11  NP_001162696.11 


ENSEMBL Gene Tree for FSCN2 (if available)
TreeFam Gene Tree for FSCN2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FSCN2 gene
FSCN32  FSCN12  
1 SIMAP similar gene for FSCN2 using alignment to 1 protein entry:     FSCN2_HUMAN:
FSCN1

FSCN2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FSCN2 (see all 418)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1378539001,2
Cuntested179495606(+) GCCTCA/GTCAAC 4 I V mis10--------
rs1512024181,2
--79493422(+) GAGGCC/TGCGGC 2 -- us2k10--------
rs1403892911,2
--79493424(+) GGCCGC/TGGCGG 2 -- us2k10--------
rs749993271,2
C--79493427(+) CGCGGC/TGGGCA 2 -- us2k10--------
rs1911157561,2
C--79493455(+) AGTTCA/GAGACC 2 -- us2k10--------
rs1823574541,2
--79493581(+) GAGCTC/TGAAGG 2 -- us2k10--------
rs72211901,2
C,F,A,H--79493705(-) GCTAGG/AGTGCT 2 -- us2k126Minor allele frequency- A:0.27NS EA NA WA CSA 2562
rs1890866391,2
--79493877(+) TCGCAC/TACAGT 2 -- us2k10--------
rs1931508061,2
--79493906(+) TGTGAA/CTCATA 2 -- us2k10--------
rs1163961961,2
C,F--79493917(+) GAGGCG/AGATGA 2 -- us2k11Minor allele frequency- A:0.03WA 118

HapMap Linkage Disequilibrium report for FSCN2 (79495417 - 79504156 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for FSCN2 (see all 22):    About this table    
Variant IDTypeSubtypePubMed ID
esv2716453CNV Deletion23290073
esv2673090CNV Deletion23128226
esv2716452CNV Deletion23290073
nsv475605CNV Insertion20440878
nsv2164CNV Insertion18451855
nsv833568CNV Loss17160897
dgv3318n71CNV Loss21882294
dgv3331n71CNV Loss21882294
dgv3332n71CNV Loss21882294
dgv3324n71CNV Loss21882294

Human Gene Mutation Database (HGMD): FSCN2
Locus Specific Mutation Databases (LSDB): FSCN2

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FSCN2
DNA2.0 Custom Variant and Variant Library Synthesis for FSCN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607643   
OMIM disorders: 607921  
UniProtKB/Swiss-Prot: FSCN2_HUMAN, O14926
  • Retinitis pigmentosa 30 (RP30) [MIM:607921]: A retinal dystrophy belonging to the group of pigmentary
    retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination
    and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically
    have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose
    their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 18 diseases for FSCN2:    
    About MalaCards
    retinitis pigmentosa 30    fscn2-related retinitis pigmentosa    retinitis    rhyns syndrome
    ehrlichiosis    dendritic cell sarcoma    retinitis pigmentosa    leber congenital amaurosis
    retinal degeneration    esophageal squamous cell carcinoma    histiocytosis    oral cancer
    blindness    esophagitis    sarcoma    squamous cell carcinoma
    multiple myeloma    myeloma

    4 diseases from the University of Copenhagen DISEASES database for FSCN2:
    Histiocytosis     Carcinoma     Retinitis pigmentosa     Dendritic cell sarcoma

    FSCN2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for FSCN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 81 8 14609921 (2), 11527955 (2), 16280978 (2), 16043865 (1) (see all 5)
    retinal degeneration 62.5 3 17251446 (2)
    retinopathy 43.7 1 16043865 (1)

    Genetic Association Database (GAD): FSCN2
    Human Genome Epidemiology (HuGE) Navigator: FSCN2 (3 documents)

    Export disorders for FSCN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FSCN2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with FSCN2)
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    1. Refinement of the RP17 locus for autosomal dominant retinitis pigmentosa, construction of a YAC contig and investigation of the candidate gene retinal fascin. (PubMed id 10234509)1, 2, 3 Bardien-Kruger S.... Ramesar R.S. (Eur. J. Hum. Genet. 1999)
    2. Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PubMed id 10783262)1, 2, 9 Tubb B.E.... Bryan J. (Genomics 2000)
    3. Autosomal dominant macular degeneration associated with 208delG mutation in the FSCN2 gene. (PubMed id 14609921)1, 4, 9 Wada Y....Tamai M. (Arch. Ophthalmol. 2003)
    4. Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa. (PubMed id 11527955)1, 2, 9 Wada Y.... Tamai M. (Invest. Ophthalmol. Vis. Sci. 2001)
    5. Sequence variations in the retinal fascin FSCN2 gene in a Spanish population with autosomal dominant retinitis pigmentosa or macular degeneration. (PubMed id 16280978)1, 4, 9 Gamundi M.J....Carballo M. (Mol. Vis. 2005)
    6. Allelic copy number variation in FSCN2 detected using allele-specific genotyping and multiplex real-time PCRs. (PubMed id 18450588)1, 4 Jin Z.B....Takahashi M. (amp 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. [Molecular genetic analysis for Japanese patients with autosomal dominant retinitis pigmentosa]. (PubMed id 14661542)1, 4 Wada Y. and Tamai M. (Nippon Ganka Gakkai Zasshi 2003)
    9. Retinal fascin: functional nature, subcellular distribution, and chromosomal localization. (PubMed id 10892848)1, 2 Saishin Y.... Shimada S. (Invest. Ophthalmol. Vis. Sci. 2000)
    10. The 208delG mutation in FSCN2 does not associate with retinal degeneration in Chinese individuals. (PubMed id 17251446)1, 9 Zhang Q....Guo X. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25794 HGNC: 3960 AceView: FSCN2 Ensembl:ENSG00000186765 euGenes: HUgn25794
    ECgene: FSCN2 H-InvDB: FSCN2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FSCN2 Pharmacogenomics, SNPs, Pathways
    Mutations of the FSCN2 genehttp://www.retina-international.org/files/sci-news/fscn2mut.htm

    (Patent information from GeneIP,
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    Patent Information for FSCN2 gene:
    Search GeneIP for patents involving FSCN2

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