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Aliases for FSCN1 Gene

Aliases for FSCN1 Gene

  • Fascin Actin-Bundling Protein 1 2 3 5
  • 55 KDa Actin-Bundling Protein 3 4
  • FAN1 3 4
  • P55 3 4
  • SNL 3 4
  • HSN 3 4
  • Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) 2
  • Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like) 2
  • Fascin Homolog 1, Actin-Bundling Protein 3
  • Singed-Like (Fascin Homolog, Sea Urchin) 3
  • Actin Bundling Protein 2
  • Singed-Like Protein 4
  • Homolog-Like 2
  • Drosophila 2
  • Singed 2

External Ids for FSCN1 Gene

Previous HGNC Symbols for FSCN1 Gene

  • SNL

Previous GeneCards Identifiers for FSCN1 Gene

  • GC07P005276
  • GC07P005376
  • GC07P005405
  • GC07P005598
  • GC07P005544

Summaries for FSCN1 Gene

Entrez Gene Summary for FSCN1 Gene

  • This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

GeneCards Summary for FSCN1 Gene

FSCN1 (Fascin Actin-Bundling Protein 1) is a Protein Coding gene. Diseases associated with FSCN1 include hodgkin lymphoma and hodgkin's lymphoma, lymphocytic-histiocytic predominance. Among its related pathways are MicroRNAs in cancer and DNA Double-Strand Break Repair. GO annotations related to this gene include poly(A) RNA binding and actin filament binding. An important paralog of this gene is FSCN2.

UniProtKB/Swiss-Prot for FSCN1 Gene

  • Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Gene Wiki entry for FSCN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSCN1 Gene

Genomics for FSCN1 Gene

Regulatory Elements for FSCN1 Gene

Promoters for FSCN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FSCN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FSCN1 Gene

Chromosome:
7
Start:
5,592,805 bp from pter
End:
5,606,656 bp from pter
Size:
13,852 bases
Orientation:
Plus strand

Genomic View for FSCN1 Gene

Genes around FSCN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSCN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSCN1 Gene

Proteins for FSCN1 Gene

  • Protein details for FSCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16658-FSCN1_HUMAN
    Recommended name:
    Fascin
    Protein Accession:
    Q16658
    Secondary Accessions:
    • A6NI89
    • B2RE97
    • Q96IC5
    • Q96IH1
    • Q9BRF1

    Protein attributes for FSCN1 Gene

    Size:
    493 amino acids
    Molecular mass:
    54530 Da
    Quaternary structure:
    • Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development. Associates with beta-catenin (By similarity). Interacts with PLXNB3 (PubMed:21706053).
    SequenceCaution:
    • Sequence=AAH07539.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FSCN1 Gene

neXtProt entry for FSCN1 Gene

Proteomics data for FSCN1 Gene at MOPED

Post-translational modifications for FSCN1 Gene

  • Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSCN1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FSCN1 (Fascin)

No data available for DME Specific Peptides for FSCN1 Gene

Domains & Families for FSCN1 Gene

Gene Families for FSCN1 Gene

HGNC:

Protein Domains for FSCN1 Gene

Suggested Antigen Peptide Sequences for FSCN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16658

UniProtKB/Swiss-Prot:

FSCN1_HUMAN :
  • Composed of four beta-trefoil domains.
  • Belongs to the fascin family.
Domain:
  • Composed of four beta-trefoil domains.
Family:
  • Belongs to the fascin family.
genes like me logo Genes that share domains with FSCN1: view

Function for FSCN1 Gene

Molecular function for FSCN1 Gene

UniProtKB/Swiss-Prot Function:
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Gene Ontology (GO) - Molecular Function for FSCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IEA,IDA 8999969
genes like me logo Genes that share ontologies with FSCN1: view
genes like me logo Genes that share phenotypes with FSCN1: view

Animal Model Products

miRNA for FSCN1 Gene

miRTarBase miRNAs that target FSCN1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSCN1 Gene

Localization for FSCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSCN1 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cell projection, microvillus. Cell junction. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol (PubMed:21706053). Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250 UniProtKB:Q61553, ECO:0000269 PubMed:21706053}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSCN1 Gene COMPARTMENTS Subcellular localization image for FSCN1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
plasma membrane 5
nucleus 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FSCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 3525578
GO:0002102 podosome IDA 20137952
GO:0005737 cytoplasm IDA 9571235
GO:0005911 cell-cell junction IDA 9571235
GO:0030027 lamellipodium IEA,ISS --
genes like me logo Genes that share ontologies with FSCN1: view

Pathways & Interactions for FSCN1 Gene

genes like me logo Genes that share pathways with FSCN1: view

Pathways by source for FSCN1 Gene

2 Reactome pathways for FSCN1 Gene
2 KEGG pathways for FSCN1 Gene
1 GeneGo (Thomson Reuters) pathway for FSCN1 Gene

Gene Ontology (GO) - Biological Process for FSCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032534 regulation of microvillus assembly IDA 9571235
GO:0035089 establishment of apical/basal cell polarity IDA 9571235
GO:0051017 actin filament bundle assembly IEA,IDA 20393565
genes like me logo Genes that share ontologies with FSCN1: view

No data available for SIGNOR curated interactions for FSCN1 Gene

Drugs & Compounds for FSCN1 Gene

(4) Drugs for FSCN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for FSCN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FSCN1: view

Transcripts for FSCN1 Gene

Unigene Clusters for FSCN1 Gene

Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSCN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -
SP7:

Relevant External Links for FSCN1 Gene

GeneLoc Exon Structure for
FSCN1
ECgene alternative splicing isoforms for
FSCN1

Expression for FSCN1 Gene

mRNA expression in normal human tissues for FSCN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FSCN1 Gene

This gene is overexpressed in Testis (10.8), Fetal Brain (7.6), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FSCN1 Gene



SOURCE GeneReport for Unigene cluster for FSCN1 Gene Hs.118400

mRNA Expression by UniProt/SwissProt for FSCN1 Gene

Q16658-FSCN1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with FSCN1: view

Protein tissue co-expression partners for FSCN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FSCN1 Gene

Orthologs for FSCN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSCN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSCN1 36
  • 100 (a)
OneToOne
FSCN1 35
  • 99.32 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia FSCN1 36
  • 93 (a)
OneToOne
FSCN1 35
  • 91.14 (n)
  • 93.1 (a)
dog
(Canis familiaris)
Mammalia FSCN1 35
  • 93.71 (n)
  • 98.17 (a)
FSCN1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fscn1 16
Fscn1 35
  • 90.33 (n)
  • 96.55 (a)
Fscn1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FSCN1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSCN1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fscn1 35
  • 90.2 (n)
  • 95.74 (a)
chicken
(Gallus gallus)
Aves FSCN1 35
  • 82.79 (n)
  • 82.24 (a)
FSCN1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FSCN1 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397934 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fscn1 35
  • 70.22 (n)
  • 73.49 (a)
MGC75811 35
zebrafish
(Danio rerio)
Actinopterygii fscn1a 36
  • 76 (a)
OneToOne
-- 35
fscn1a 35
  • 73.27 (n)
  • 75.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta sn 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for FSCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSCN1 Gene

ENSEMBL:
Gene Tree for FSCN1 (if available)
TreeFam:
Gene Tree for FSCN1 (if available)

Paralogs for FSCN1 Gene

Paralogs for FSCN1 Gene

(1) SIMAP similar genes for FSCN1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FSCN1 Gene

genes like me logo Genes that share paralogs with FSCN1: view

Variants for FSCN1 Gene

Sequence variations from dbSNP and Humsavar for FSCN1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs852478 -- 5,599,602(-) ACTCC(A/T)GGACT intron-variant
rs852479 -- 5,599,495(-) ATGCA(G/T)CCCCA intron-variant
rs852480 -- 5,598,865(+) GTGGC(C/T)GGCAC intron-variant
rs852481 -- 5,598,094(-) AGGCC(A/C)CACCC intron-variant
rs852482 -- 5,597,684(-) TTTTT(G/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSCN1 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
dgv7142n71 CNV Loss 21882294
nsv830890 CNV Loss 17160897
dgv7143n71 CNV Loss 21882294
esv2665366 CNV Deletion 23128226
nsv819922 CNV Gain 19587683

Variation tolerance for FSCN1 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSCN1 Gene

HapMap Linkage Disequilibrium report
FSCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSCN1 Gene

Disorders for FSCN1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for FSCN1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
hodgkin's lymphoma, lymphocytic-histiocytic predominance
  • hodgkin lymphoma, lymphocyte-rich
esophageal cancer
  • esophageal cancer, somatic
papilloma
  • papillomatosis
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FSCN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FSCN1

Genetic Association Database (GAD)
FSCN1
Human Genome Epidemiology (HuGE) Navigator
FSCN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSCN1
genes like me logo Genes that share disorders with FSCN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FSCN1 Gene

Publications for FSCN1 Gene

  1. cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. (PMID: 8068206) Duh F.-M. … Gnarra J.R. (DNA Cell Biol. 1994) 2 3 4 23 67
  2. Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PMID: 10783262) Tubb B.E. … Bryan J. (Genomics 2000) 2 3 23
  3. Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma. (PMID: 19741544) Zou J. … Liu S. (Eur. J. Cancer Prev. 2010) 3 23
  4. Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression. (PMID: 19818782) Kim S.J. … Chun K.H. (Gastroenterology 2010) 3 23
  5. Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. (PMID: 20056838) Xie J.J. … Li E.M. (Am. J. Pathol. 2010) 3 23

Products for FSCN1 Gene

Sources for FSCN1 Gene

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