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Aliases for FSCN1 Gene

Aliases for FSCN1 Gene

  • Fascin Actin-Bundling Protein 1 2 3
  • SNL 3 4 6
  • 55 KDa Actin-Bundling Protein 3 4
  • FAN1 3 4
  • P55 3 4
  • HSN 3 4
  • Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) 2
  • Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like) 2
  • Fascin Homolog 1, Actin-Bundling Protein 3
  • Singed-Like (Fascin Homolog, Sea Urchin) 3
  • Actin Bundling Protein 2
  • Singed-Like Protein 4
  • Homolog-Like 2
  • Drosophila 2
  • Singed 2
  • Fascin 3

External Ids for FSCN1 Gene

Previous Symbols for FSCN1 Gene

  • SNL

Summaries for FSCN1 Gene

Entrez Gene Summary for FSCN1 Gene

  • This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

GeneCards Summary for FSCN1 Gene

FSCN1 (Fascin Actin-Bundling Protein 1) is a Protein Coding gene. Diseases associated with FSCN1 include interdigitating dendritic cell sarcoma and juvenile xanthogranuloma. Among its related pathways are MicroRNAs in cancer and Cytoskeletal Signaling. GO annotations related to this gene include actin binding and drug binding. An important paralog of this gene is FSCN2.

UniProtKB/Swiss-Prot for FSCN1 Gene

  • Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Gene Wiki entry for FSCN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSCN1 Gene

Genomics for FSCN1 Gene

Genomic Location for FSCN1 Gene

Start:
5,592,805 bp from pter
End:
5,606,656 bp from pter
Size:
13,852 bases
Orientation:
Plus strand

Genomic View for FSCN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FSCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSCN1 Gene

Regulatory Elements for FSCN1 Gene

Proteins for FSCN1 Gene

  • Protein details for FSCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16658-FSCN1_HUMAN
    Recommended name:
    Fascin
    Protein Accession:
    Q16658
    Secondary Accessions:
    • A6NI89
    • B2RE97
    • Q96IC5
    • Q96IH1
    • Q9BRF1

    Protein attributes for FSCN1 Gene

    Size:
    493 amino acids
    Molecular mass:
    54530 Da
    Quaternary structure:
    • Associates with beta-catenin. Interacts with PLXNB3.
    SequenceCaution:
    • Sequence=AAH07539.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FSCN1 Gene

neXtProt entry for FSCN1 Gene

Proteomics data for FSCN1 Gene at MOPED

Post-translational modifications for FSCN1 Gene

  • Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSCN1 Gene

No data available for DME Specific Peptides for FSCN1 Gene

Domains for FSCN1 Gene

Gene Families for FSCN1 Gene

HGNC:

Protein Domains for FSCN1 Gene

UniProtKB/Swiss-Prot:

FSCN1_HUMAN
Domain:
  • Composed of four beta-trefoil domains.:
    • Q16658
Family:
  • Belongs to the fascin family.:
    • Q16658
genes like me logo Genes that share domains with FSCN1: view

Function for FSCN1 Gene

Molecular function for FSCN1 Gene

UniProtKB/Swiss-Prot Function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Gene Ontology (GO) - Molecular Function for FSCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 20393565
GO:0005515 protein binding IPI 15161933
GO:0008144 drug binding IDA 20393565
GO:0030674 protein binding, bridging IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FSCN1: view

Phenotypes for FSCN1 Gene

genes like me logo Genes that share phenotypes with FSCN1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FSCN1 Gene

Localization for FSCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSCN1 Gene

Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSCN1 Gene COMPARTMENTS Subcellular localization image for FSCN1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FSCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 3525578
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0015629 actin cytoskeleton IDA 3525578
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with FSCN1: view

Pathways for FSCN1 Gene

genes like me logo Genes that share pathways with FSCN1: view

Pathways by source for FSCN1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for FSCN1 Gene
2 Cell Signaling Technology pathways for FSCN1 Gene
2 KEGG pathways for FSCN1 Gene

Gene Ontology (GO) - Biological Process for FSCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 8068206
GO:0016477 cell migration IMP 20393565
GO:0030036 actin cytoskeleton organization IDA 9571235
GO:0048870 cell motility IDA 9571235
GO:0051017 actin filament bundle assembly IDA 20393565
genes like me logo Genes that share ontologies with FSCN1: view

Compounds for FSCN1 Gene

(7) Novoseek inferred chemical compound relationships for FSCN1 Gene

Compound -log(P) Hits PubMed IDs
paraffin 30.6 3
serine 14.8 4
12-o-tetradecanoylphorbol 13-acetate 10.3 5
calcium 0 3
threonine 0 1
genes like me logo Genes that share compounds with FSCN1: view

Transcripts for FSCN1 Gene

Unigene Clusters for FSCN1 Gene

Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSCN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -
SP7:

Relevant External Links for FSCN1 Gene

GeneLoc Exon Structure for
FSCN1
ECgene alternative splicing isoforms for
FSCN1

Expression for FSCN1 Gene

mRNA expression in normal human tissues for FSCN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FSCN1 Gene

SOURCE GeneReport for Unigene cluster for FSCN1 Gene Hs.118400

mRNA Expression by UniProt/SwissProt for FSCN1 Gene

Q16658-FSCN1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with FSCN1: view

Orthologs for FSCN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSCN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSCN1 36
  • 99.32 (n)
  • 100 (a)
FSCN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FSCN1 36
  • 91.14 (n)
  • 93.1 (a)
FSCN1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FSCN1 36
  • 93.71 (n)
  • 98.17 (a)
FSCN1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fscn1 36
  • 90.33 (n)
  • 96.55 (a)
Fscn1 16
Fscn1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FSCN1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSCN1 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fscn1 36
  • 90.2 (n)
  • 95.74 (a)
chicken
(Gallus gallus)
Aves FSCN1 36
  • 82.79 (n)
  • 82.24 (a)
FSCN1 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FSCN1 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397934 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fscn1 36
  • 70.22 (n)
  • 73.49 (a)
MGC75811 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
fscn1a 36
  • 73.27 (n)
  • 75.92 (a)
fscn1a 37
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sn 37
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for FSCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSCN1 Gene

ENSEMBL:
Gene Tree for FSCN1 (if available)
TreeFam:
Gene Tree for FSCN1 (if available)

Paralogs for FSCN1 Gene

Paralogs for FSCN1 Gene

Selected SIMAP similar genes for FSCN1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FSCN1 Gene

genes like me logo Genes that share paralogs with FSCN1: view

Variants for FSCN1 Gene

Sequence variations from dbSNP and Humsavar for FSCN1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs8772 -- 5,606,600(+) GCCCA(C/T)GATAG utr-variant-3-prime
rs852478 -- 5,599,602(-) ACTCC(A/T)GGACT intron-variant
rs852479 -- 5,599,495(-) ATGCA(G/T)CCCCA intron-variant
rs852480 -- 5,598,865(+) GTGGC(C/T)GGCAC intron-variant
rs852481 -- 5,598,094(-) AGGCC(A/C)CACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSCN1 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
dgv7142n71 CNV Loss 21882294
nsv830890 CNV Loss 17160897
dgv7143n71 CNV Loss 21882294
esv2665366 CNV Deletion 23128226
nsv819922 CNV Gain 19587683

Relevant External Links for FSCN1 Gene

HapMap Linkage Disequilibrium report
FSCN1

Disorders for FSCN1 Gene

(3) University of Copenhagen DISEASES for FSCN1 Gene

(59) Novoseek inferred disease relationships for FSCN1 Gene

Disease -log(P) Hits PubMed IDs
juvenile xanthogranuloma 56.7 1
tumors 47.7 122
carcinoma 46.7 60
epithelial tumor 45 6
adenocarcinoma 44.2 42

Relevant External Links for FSCN1

Genetic Association Database (GAD)
FSCN1
Human Genome Epidemiology (HuGE) Navigator
FSCN1
genes like me logo Genes that share disorders with FSCN1: view

No data available for UniProtKB/Swiss-Prot for FSCN1 Gene

Publications for FSCN1 Gene

  1. cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. (PMID: 8068206) Duh F.-M. … Gnarra J.R. (DNA Cell Biol. 1994) 2 3 4 23
  2. Phosphorylation of human fascin inhibits its actin binding and bundling activities. (PMID: 8647875) Yamakita Y. … Yamashiro S. (J. Biol. Chem. 1996) 3 4 23
  3. Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. (PMID: 8999969) Ono S. … Matsumura F. (J. Biol. Chem. 1997) 3 4 23
  4. Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin- bundling protein. (PMID: 7933116) Mosialos G. … Birkenbach M. (J. Virol. 1994) 3 4 23
  5. Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PMID: 10783262) Tubb B.E. … Bryan J. (Genomics 2000) 2 3 23

Products for FSCN1 Gene

  • Addgene plasmids for FSCN1

Sources for FSCN1 Gene

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