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FSCN1 Gene

protein-coding   GIFtS: 62
GCID: GC07P005632

Fascin Actin-Bundling Protein 1

(Previous names: singed (Drosophila)-like (sea urchin fascin homolog like),...)
(Previous symbol: SNL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fascin Actin-Bundling Protein 11 2     drosophila1
SNL1 2 3 5     Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus)1
55 KDa Actin-Bundling Protein2 3     homolog-like1
FAN12 3     Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like)1
HSN2 3     fascin2
p552 3     Fascin Homolog 1, Actin-Bundling Protein2
Singed1     Singed-Like (Fascin Homolog, Sea Urchin)2
Actin Bundling Protein1     Singed-Like Protein3

External Ids:    HGNC: 111481   Entrez Gene: 66242   Ensembl: ENSG000000756187   OMIM: 6026895   UniProtKB: Q166583   

Export aliases for FSCN1 gene to outside databases

Previous GC identifers: GC07P005276 GC07P005376 GC07P005405 GC07P005598 GC07P005544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FSCN1 Gene:
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into
parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein
plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is
known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of
multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg
cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. (provided by
RefSeq, Sep 2011)

GeneCards Summary for FSCN1 Gene:
FSCN1 (fascin actin-bundling protein 1) is a protein-coding gene. Diseases associated with FSCN1 include interdigitating dendritic cell sarcoma, and juvenile xanthogranuloma. GO annotations related to this gene include drug binding and actin binding. An important paralog of this gene is FSCN2.

UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658
Function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the
organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers.
Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and
migration

Gene Wiki entry for FSCN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FSCN1 gene promoter:
         CREB   p53   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FSCN1 promoter sequence
   Search Chromatin IP Primers for FSCN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FSCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22

FSCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSCN1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P005632:  view genomic region     (about GC identifiers)

Start:
5,632,439 bp from pter      End:
5,646,286 bp from pter
Size:
13,848 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 5,678,799-5,692,631     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658 (See protein sequence)
Recommended Name: Fascin  
Size: 493 amino acids; 54530 Da
Subunit: Associates with beta-catenin. Interacts with PLXNB3
Selected PDB 3D structures from and Proteopedia for FSCN1 (see all 8):
1DFC (3D)        3LLP (3D)        3O8K (3D)        3P53 (3D)        4GOV (3D)        4GOY (3D)    
Secondary accessions: A6NI89 B2RE97 Q96IC5 Q9BRF1

Explore the universe of human proteins at neXtProt for FSCN1: NX_Q16658

Explore proteomics data for FSCN1 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FSCN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003079.1  
    ENSEMBL proteins: 
     ENSP00000371798   ENSP00000404506   ENSP00000409967   ENSP00000383982   ENSP00000339729  

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    FSCN1 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FSCN: Fascins

    4 InterPro protein domains:
     IPR010431 Fascin
     IPR022768 Fascin-domain
     IPR024703 Fascin_metazoans
     IPR008999 Actin_cross-linking

    Graphical View of Domain Structure for InterPro Entry Q16658

    ProtoNet protein and cluster: Q16658

    UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658
    Domain: Composed of four beta-trefoil domains
    Similarity: Belongs to the fascin family


    FSCN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSCN1_HUMAN, Q16658
    Function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the
    organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers.
    Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and
    migration

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA--
    GO:0005515protein binding IPI15161933
    GO:0008144drug binding IDA--
    GO:0030674protein binding, bridging IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    FSCN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fscn1):
     cellular  immune system 

    FSCN1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FSCN1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FSCN1
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    miRNA
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    miRTarBase miRNAs that target FSCN1:
    hsa-mir-133a-3p (MIRT003542), hsa-mir-30a-5p (MIRT028511), hsa-mir-221-3p (MIRT046860), hsa-mir-143-3p (MIRT005771), hsa-mir-17-3p (MIRT050745), hsa-mir-133b (MIRT006554), hsa-mir-145-5p (MIRT003543)

    Block miRNA regulation of human, mouse, rat FSCN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FSCN1 (see all 30):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-429 hsa-miR-330-5p hsa-miR-488 hsa-miR-759 hsa-miR-583 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidFSCN1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FSCN1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FSCN1 (NM_003088)
    Sino Biological Human cDNA Clone for FSCN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FSCN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCN1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FSCN1_HUMAN, Q16658: Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium.
    Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    plasma membrane4
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA3525578
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0005856cytoskeleton ----
    GO:0015629actin cytoskeleton IDA3525578

    FSCN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FSCN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3MicroRNAs in cancer
    MicroRNAs in cancer
    4Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for FSCN1
        Wnt / Hedgehog / Notch
    Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for FSCN1
        Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases



    1 Kegg Pathway  (Kegg details for FSCN1):
        MicroRNAs in cancer


    FSCN1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FSCN1
    Interactions:

        GeneGlobe Interaction Network for FSCN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FSCN1 (Q166581, 2, 3 ENSP000003717984) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406921, 3, ENSP000002317904EBI-351076,EBI-744248 I2D: score=1 STRING: ENSP00000231790
    MAPK8IP2Q133872, 3MINT-8262473 I2D: score=2 
    YWHAZP631041, 2, 3, ENSP000003095034EBI-351076,EBI-347088 MINT-3298006 I2D: score=2 STRING: ENSP00000309503
    GNASP630923, ENSP000003601414I2D: score=1 I2D: score=1 STRING: ENSP00000360141
    FANCD2Q9BXW91, 3, ENSP000002876474EBI-351076,EBI-359343 I2D: score=1 STRING: ENSP00000287647
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008283cell proliferation TAS8068206
    GO:0016477cell migration IMP--
    GO:0030036actin cytoskeleton organization IDA9571235
    GO:0048870cell motility IDA9571235
    GO:0051017actin filament bundle assembly IDA--

    FSCN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FSCN1

    7 Novoseek inferred chemical compound relationships for FSCN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 30.6 3 10199466 (1), 18630479 (1), 16524962 (1)
    serine 14.8 4 8663066 (1), 10979967 (1), 12789270 (1), 19592575 (1)
    12-o-tetradecanoylphorbol 13-acetate 10.3 7 8647875 (2), 10588651 (2), 11169763 (1)
    calcium 0 3 8461306 (1), 8663066 (1), 1993662 (1)
    threonine 0 1 10979967 (1)
    tyrosine 0 2 1713685 (1), 18215522 (1)
    retinoic acid 0 5 15882811 (2)



    FSCN1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FSCN1 gene: 
    NM_003088.3  

    Unigene Cluster for FSCN1:

    Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
    Hs.118400  [show with all ESTs]
    Unigene Representative Sequence: NM_003088
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382361(uc003sou.3) ENST00000444748 ENST00000447103 ENST00000405801
    ENST00000473330(uc003sov.3) ENST00000340250
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FSCN1 (see all 30):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-429 hsa-miR-330-5p hsa-miR-488 hsa-miR-759 hsa-miR-583 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidFSCN1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FSCN1
      QuantiFast Probe-based Assays in human, mouse, rat FSCN1

    Additional mRNA sequence: 

    AK095254.1 AK095830.1 AK125295.1 AK316607.1 BC000521.2 BC006304.2 BC007539.1 BC007643.1 
    BC007948.2 BC007988.2 BT006636.1 U03057.1 U09873.1 

    Selected DOTS entries (see all 35):

    DT.100803234  DT.418036  DT.95081237  DT.121045864  DT.99926447  DT.121045878  DT.99926448  DT.95327912 
    DT.121045924  DT.92464992  DT.86856588  DT.100667235  DT.100859446  DT.100667240  DT.100667233  DT.100667241 
    DT.121045917  DT.100667238  DT.121045859  DT.95081248  DT.100667236  DT.121045929  DT.121045872  DT.121082090 

    Selected AceView cDNA sequences (see all 825):

    BC006304 W86008 BE884569 W02155 BE262096 BE784542 BM909130 AI081938 
    AI719748 BU951859 BC007643 BE551908 CD244620 BE885852 AU131897 BM562887 
    AI880115 BM552636 AI218944 BQ937720 BU630025 AI656126 AW016765 AI568493 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FSCN1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c
    SP1:        -     -     -     -     -                                                           -                     
    SP2:                                                                                            -                     
    SP3:              -     -     -     -                                                                                 
    SP4:                          -     -                                                                                 
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for FSCN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FSCN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGTAGCTT
    FSCN1 Expression
    About this image


    FSCN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Progress Zone Cells Limb Bud
             Limb Bud
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
     
     Bone (Muscoskeletal System)
             Progress Zone Cells Limb Bud
    FSCN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FSCN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118400

    UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FSCN1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fscn11 , 5 fascin homolog 1, actin bundling protein (Strongylocentrotus more1, 5 90.33(n)1
    96.55(a)1
      5 (81.84 cM)5
    140861  NM_007984.21  NP_032010.21 
     1429603435 
    chicken
    (Gallus gallus)
    Aves FSCN11 fascin homolog 1, actin-bundling protein (Strongylocentrotus more 82.79(n)
    82.24(a)
      416485  NM_001178132.1  NP_001171603.1 
    lizard
    (Anolis carolinensis)
    Reptilia FSCN16
    fascin homolog 1, actin-bundling protein (Strongyl...
    83(a)
    1 ↔ 1
    GL343725.1(14496-23507)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979342 fascin 76.72(n)    X75938.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK239458.12   -- 77.47(n)   324960  CK239458.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sn6
    singed
    37(a)
    1 → many
    X(7858057-7880118)


    ENSEMBL Gene Tree for FSCN1 (if available)
    TreeFam Gene Tree for FSCN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FSCN1 gene
    FSCN22  FSCN32  
    1 SIMAP similar gene for FSCN1 using alignment to 6 protein entries:     FSCN1_HUMAN (see all proteins):
    FSCN2

    FSCN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FSCN1
    PGOHUM00000258955


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FSCN1 (see all 450)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs132375921,2
    C,F,H--5601627(+) ATTCTC/TTTTTC 1 -- us2k1 trp36Minor allele frequency- T:0.00NS EA NA 702
    rs754488181,2
    F--5601635(+) TTCCCC/TCGTCC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1474407551,2
    --5601660(+) ATCTGG/TAGCTC 1 -- us2k10--------
    rs1855892811,2
    --5601694(+) CCTGGA/CAGCAG 1 -- us2k10--------
    rs1394336191,2
    --5601754(+) ACAAAC/TACCTA 1 -- us2k10--------
    rs1450028061,2
    --5601778(+) CAATGA/GACAGA 1 -- us2k10--------
    rs2017827011,2
    --5601839(+) TCGTC-/TATT  
            
    TATCT
    1 -- us2k10--------
    rs733344491,2
    C--5601842(+) TCTATC/TTATCT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1507184161,2
    C--5601842(+) CTATT-/TATC  
            
    TTATC
    1 -- us2k10--------
    rs1931729881,2
    --5601930(+) GGCCTC/TAAGCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FSCN1 (5632439 - 5646286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FSCN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665366CNV Deletion23128226
    nsv436904CNV Insertion17901297
    dgv7143n71CNV Loss21882294
    nsv830890CNV Loss17160897
    dgv7142n71CNV Loss21882294
    nsv819922CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FSCN1
    DNA2.0 Custom Variant and Variant Library Synthesis for FSCN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602689    OMIM disorders: --

    Selected diseases for FSCN1 (see all 73):    
    About MalaCards
    interdigitating dendritic cell sarcoma    juvenile xanthogranuloma    mononeuropathy    ampulla of vater adenocarcinoma
    rosai-dorfman disease    inverted papilloma    follicular dendritic cell tumor    dendritic cell sarcoma
    papilloma    pulmonary neuroendocrine tumor    pleomorphic carcinoma    castleman's disease
    langerhans-cell histiocytosis    follicular dendritic cell sarcoma    hodgkin's lymphoma    cancer progression/metastasis
    angiosarcoma    histiocytosis    bile duct carcinoma    anaplastic astrocytoma

    3 diseases from the University of Copenhagen DISEASES database for FSCN1:
    Histiocytosis     Carcinoma     Inverted papilloma

    FSCN1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FSCN1 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    juvenile xanthogranuloma 56.7 1 10463281 (1)
    tumors 47.7 165 19188814 (6), 17419223 (6), 20186299 (4), 11206843 (4) (see all 68)
    carcinoma 46.7 83 19556073 (7), 19061289 (6), 19340314 (5), 18498068 (5) (see all 29)
    epithelial tumor 45 8 15814639 (1), 15557788 (1), 18343949 (1), 18498068 (1) (see all 6)
    adenocarcinoma 44.2 46 17696949 (7), 17029629 (6), 12592367 (5), 17473384 (5) (see all 15)
    aggressiveness 43.5 12 19188814 (4), 17499430 (2), 16977579 (2), 18776588 (1) (see all 6)
    metastasis 43.2 59 20186299 (5), 14568688 (4), 18575752 (3), 18343949 (3) (see all 28)
    hodgkin disease 41.7 8 9033270 (3), 17488159 (2), 19550297 (1), 12579989 (1)
    carcinoma mucinous 41 1 15626919 (1)
    ovarian carcinoma 40.2 8 18776588 (2), 16620064 (1), 16620052 (1), 19245589 (1) (see all 5)

    Genetic Association Database (GAD): FSCN1
    Human Genome Epidemiology (HuGE) Navigator: FSCN1 (1 document)

    Export disorders for FSCN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FSCN1 gene, integrated from 10 sources (see all 316):
    (articles sorted by number of sources associating them with FSCN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. (PubMed id 8068206)1, 2, 3, 9 Duh F.-M.... Gnarra J.R. (DNA Cell Biol. 1994)
    2. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. (PubMed id 9571235)1, 2, 9 Yamashiro S.... Matsumura F. (Mol. Biol. Cell 1998)
    3. Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin- bundling protein. (PubMed id 7933116)1, 2, 9 Mosialos G.... Birkenbach M. (J. Virol. 1994)
    4. Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. (PubMed id 8999969)1, 2, 9 Ono S.... Matsumura F. (J. Biol. Chem. 1997)
    5. Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PubMed id 10783262)1, 3, 9 Tubb B.E.... Bryan J. (Genomics 2000)
    6. Phosphorylation of human fascin inhibits its actin binding and bundling activities. (PubMed id 8647875)1, 2, 9 Yamakita Y.... Yamashiro S. (J. Biol. Chem. 1996)
    7. The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. (PubMed id 20137952)1, 2, 9 Li A.... Machesky L.M. (Curr. Biol. 2010)
    8. Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein. (PubMed id 20434460)1, 2 Sedeh R.S.... Bathe M. (J. Mol. Biol. 2010)
    9. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6624 HGNC: 11148 AceView: FSCN1 Ensembl:ENSG00000075618 euGenes: HUgn6624
    ECgene: FSCN1 Kegg: 6624 H-InvDB: FSCN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FSCN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FSCN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FSCN1 gene:
    Search GeneIP for patents involving FSCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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