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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FSCN1 Gene

protein-coding GIFtS: 61
GCID: GC07P005632

fascin homolog 1, actin-bundling protein (Strongylocentrotus...

(Previous name: singed (Drosophila)-like (sea urchin fascin homolog like)...)
(Previous symbol: SNL)

Explore 75 diseases affiliated with
FSCN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus)¹ ²		FLJ38511¹
SNL¹ ² ³ ⁵		Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like)¹
P55¹		Fascin¹
55 KDa Actin-Bundling Protein² ³		Singed-Like (Fascin Homolog, Sea Urchin)²
FAN1² ³		Singed-Like Protein³
HSN² ³

External Ids:	HGNC: 11148¹	Entrez Gene: 6624²	Ensembl: ENSG00000075618⁷	OMIM: 602689⁵	UniProtKB: Q16658³

Export aliases for FSCN1 gene to outside databases

Previous GC identifers: GC07P005276 GC07P005376 GC07P005405 GC07P005598 GC07P005544

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FSCN1:

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into

parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a

critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be

regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of

cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's

lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658

Function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the

organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers.

Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and

migration

Gene Wiki entry for FSCN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FSCN1 gene promoter:
CREB p53 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FSCN1 promoter sequence

Search SABiosciences Chromatin IP Primers for FSCN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSCN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22

FSCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSCN1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P005632: view genomic region (about GC identifiers)

Start:	5,632,439 bp from pter	End:	5,646,286 bp from pter
Size:	13,848 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 5,678,799-5,692,631

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658 (See protein sequence)

Recommended Name: Fascin

Size: 493 amino acids; 54530 Da

Subunit: Associates with beta-catenin. Interacts with PLXNB3

Subcellular location: Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm,

cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol

6/8 PDB 3D structures from and Proteopedia for FSCN1 (see all 8):

1DFC (3D)

3LLP (3D)

3O8K (3D)

3P53 (3D)

4GOV (3D)

4GOY (3D)

Secondary accessions: A6NI89 B2RE97 Q96IC5 Q9BRF1

Explore the universe of human proteins at neXtProt for FSCN1: NX_Q16658

Post-translational modifications:

Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16658

FSCN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003079.1

ENSEMBL proteins:

ENSP00000371798 ENSP00000404506 ENSP00000409967 ENSP00000383982 ENSP00000339729

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for FSCN1
	Uscn Proteins for FSCN1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IDA	3525578
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	IEA	--
GO:0015629	actin cytoskeleton	IDA	3525578
GO:0030054	cell junction	IEA	--

FSCN1 for ontologies About GeneDecksing

FSCN1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FSCN1
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	Abcam antibodies for FSCN1
	Uscn Antibodies for FSCN1
	ThermoFisher Antibodies for FSCN1

Assay Products for FSCN1:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for FSCN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FSCN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FSCN1 for domains About GeneDecksing

3 InterPro domains/families:

IPR022768 Fascin-domain

IPR024703 Fascin

IPR008999 Actin_cross-linking

Graphical View of Domain Structure for InterPro Entry Q16658

ProtoNet protein and cluster: Q16658

UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658

Domain: Composed of four beta-trefoil domains

Similarity: Belongs to the fascin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658

Function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the

organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers.

Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and

migration

miRNA Products:		miRTarBase miRNAs that target FSCN1: hsa-mir-133a (MIRT003542), hsa-mir-143 (MIRT005771), hsa-mir-145 (MIRT003543)

		OriGene 3'-UTR Clone: FSCN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FSCN1
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate FSCN1 (see all 30):
		hsa-miR-300 hsa-miR-520d-5p hsa-miR-429 hsa-miR-330-5p hsa-miR-488 hsa-miR-759 hsa-miR-583 hsa-miR-661

		SwitchGear 3'UTR luciferase reporter plasmid: FSCN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FSCN1 (see all 4) OriGene shRNA RFP: FSCN1 OriGene siRNA: FSCN1
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FSCN1
		Search LifeMap BioReagents cell lines for FSCN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	--
GO:0005515	protein binding	IPI	--
GO:0008144	drug binding	IDA	--
GO:0030674	protein binding, bridging	IEA	--
GO:0051015	actin filament binding	IDA	17671164

FSCN1 for ontologies About GeneDecksing

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fscn1):

cellular

immune system

FSCN1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases

0.49

Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases

0.49

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FSCN1

Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases

2 Cell Signaling Technology (CST) Pathways for FSCN1

	Wnt / Hedgehog / Notch
	Cytoskeletal Signaling

1 GeneGo (Thomson Reuters) Pathway for FSCN1

Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases

FSCN1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FSCN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for FSCN1 (Q16658^{1, 2, 3} ENSP00000371798⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MLH1	P40692¹^,³, ENSP00000231790⁴	EBI-351076,EBI-744248 I2D: score=1 STRING: ENSP00000231790
MAPK8IP2	Q13387²^,³	MINT-8262473 I2D: score=2
GNAS	P63092³, ENSP00000360141⁴	I2D: score=1 I2D: score=1 STRING: ENSP00000360141
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3298006 I2D: score=2 STRING: ENSP00000309503
FANCD2	Q9BXW9¹^,³, ENSP00000287647⁴	EBI-351076,EBI-359343 I2D: score=1 STRING: ENSP00000287647

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008283	cell proliferation	TAS	8068206
GO:0016477	cell migration	IMP	--
GO:0030036	actin cytoskeleton organization	IDA	9571235
GO:0048870	cell motility	IDA	9571235
GO:0051017	actin filament bundle assembly	IDA	--

FSCN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FSCN1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FSCN1
7 Novoseek chemical compound relationships for FSCN1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
paraffin	30.6	3	10199466 (1), 18630479 (1), 16524962 (1)
serine	14.8	4	8663066 (1), 10979967 (1), 12789270 (1), 19592575 (1)
12-o-tetradecanoylphorbol 13-acetate	10.3	7	8647875 (2), 10588651 (2), 11169763 (1)
calcium	0	3	8461306 (1), 8663066 (1), 1993662 (1)
threonine	0	1	10979967 (1)
tyrosine	0	2	1713685 (1), 18215522 (1)
retinoic acid	0	5	15882811 (2)

Search CenterWatch for drugs/clinical trials and news about FSCN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FSCN1 gene:

NM_003088.3

Unigene Cluster for FSCN1:

Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

Hs.118400 [show with all ESTs]

Unigene Representative Sequence: NM_003088

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382361(uc003sou.3) ENST00000444748 ENST00000447103 ENST00000405801

ENST00000473330(uc003sov.3) ENST00000461793 ENST00000340250

miRNA Products:		OriGene 3'-UTR Clone: FSCN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FSCN1
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate FSCN1 (see all 30):
		hsa-miR-300 hsa-miR-520d-5p hsa-miR-429 hsa-miR-330-5p hsa-miR-488 hsa-miR-759 hsa-miR-583 hsa-miR-661

		SwitchGear 3'UTR luciferase reporter plasmid: FSCN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: FSCN1 (NM_003088)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSCN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSCN1

Additional cDNA sequence:

AK095254.1 AK095830.1 AK125295.1 AK316607.1 BC000521.2 BC006304.2 BC007539.1 BC007643.1

BC007948.2 BC007988.2 BT006636.1 U03057.1 U09873.1

24/35 DOTS entries (see all 35):

DT.100803234 DT.418036 DT.95081237 DT.121045864 DT.99926447 DT.121045878 DT.99926448 DT.95327912

DT.121045924 DT.92464992 DT.86856588 DT.100667235 DT.100859446 DT.100667240 DT.100667233 DT.100667241

DT.121045917 DT.100667238 DT.121045859 DT.95081248 DT.100667236 DT.121045929 DT.121045872 DT.121082090

24/825 AceView cDNA sequences (see all 825):

AI218944 AI434053 BQ926129 BE262096 AI990944 BU552760 BU501058 BQ575063

CA416209 AI568575 BE297011 BM667037 BE812209 AU131897 BC000521 AI633812

BF434688 BE877618 CA444961 AI627739 BU162629 BQ673264 AI364353 CB132967

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FSCN1 (see all 7) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	^	7	^	8a	·	8b	·	8c
SP1:			-		-		-		-		-																				-
SP2:																															-
SP3:					-		-		-		-
SP4:									-		-
SP5:											-

ECgene alternative splicing isoforms for FSCN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FSCN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAGTAGCTT

About this image

FSCN1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Basal Cells

Lung

Trachea

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Endoderm-like cells (Generation of hepato...)

Definitive endoderm-like cells (A scalable, suspensi...)

See FSCN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FSCN1

SOURCE GeneReport for Unigene cluster: Hs.118400

UniProtKB/Swiss-Prot: FSCN1_HUMAN, Q16658

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for FSCN1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSCN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FSCN1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FSCN1¹	fascin homolog 1, actin-bundling protein (Strongylocentrotus more	82.79(n) 82.24(a)		416485 NM_001178132.1 NP_001171603.1
lizard (Anolis carolinensis)	Reptilia	FSCN1⁶	--	84(a)	1 ↔ 1	GL343725.1(15297-18946)
African clawed frog (Xenopus laevis)	Amphibia	LOC397934²	fascin	76.72(n)		X75938.1
zebrafish (Danio rerio)	Actinopterygii	CK239458.1²	--	77.47(n)		324960 CK239458.1
fruit fly (Drosophila melanogaster)	Insecta	sn¹	singed	53.73(n) 42.19(a)		31717 NM_001169225.1 NP_001162696.1

ENSEMBL Gene Tree for FSCN1 (if available)
TreeFam Gene Tree for FSCN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FSCN1 gene

FSCN2² FSCN3²

1 SIMAP similar gene for FSCN1 using alignment to 6 protein entries: FSCN1_HUMAN (see all proteins):

FSCN2

FSCN1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for FSCN1
PGOHUM00000258955

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147440755^1,2		--	5630501(+)	`ATCTGG/TAGCTC`	1	--	us2k¹		0	--	--	--	--
rs185589281^1,2		--	5630535(+)	`CCTGGA/CAGCAG`	1	--	us2k¹		0	--	--	--	--
rs139433619^1,2		--	5630595(+)	`ACAAAC/TACCTA`	1	--	us2k¹		0	--	--	--	--
rs145002806^1,2		--	5630619(+)	`CAATGA/GACAGA`	1	--	us2k¹		0	--	--	--	--
rs201782701^1,2		--	5630680(+)	`TCGTC-/TATT TATCT`	1	--	us2k¹		0	--	--	--	--
rs150718416^1,2	C,	--	5630683(+)	`CTATT-/TATC TTATC`	1	--	us2k¹		0	--	--	--	--
rs35136139^1,2	C	--	5630729(+)	`ATCTA-/TCTA GATGA`	1	--	us2k¹		0	--	--	--	--
rs193172988^1,2		--	5630771(+)	`GGCCTC/TAAGCG`	1	--	us2k¹		0	--	--	--	--
rs56206206^1,2	C,	--	5631015(+)	`ACATGT/GTGGCT`	1	--	us2k¹		5		NA CSA WA EA	361
rs147567197^1,2		--	5631133(+)	`CAAGGA/CCCTGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FSCN1 (5632439 - 5646286 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FSCN1
2 CNVs: 4524 59413

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FSCN1 for disorders           About GeneDecksing

OMIM gene information: 602689    OMIM disorders: --

20/75 diseases for FSCN1 (see all 75):    About MalaCards

hodgkin's lymphoma rosai-dorfman disease langerhans-cell histiocytosis interdigitating dendritic cell sarcoma

wiskott-aldrich syndrome dendritic cell sarcoma juvenile xanthogranuloma anaplastic large cell lymphoma

diffuse large b-cell lymphoma follicular dendritic cell sarcoma follicular dendritic cell tumor b-cell lymphomas

smooth muscle tumor clear cell renal cell carcinoma bile duct carcinoma inverted papilloma

squamous cell carcinoma soft tissue sarcoma bile duct cancer castleman's disease

3 diseases from the University of Copenhagen DISEASES database for FSCN1:

Carcinoma Histiocytosis Inverted papilloma

10/59 Novoseek disease relationships for FSCN1 gene (see all 59) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
juvenile xanthogranuloma	56.7	1	10463281 (1)
tumors	47.7	165	19188814 (6), 17419223 (6), 20186299 (4), 11206843 (4) (see all 68)
carcinoma	46.7	83	19556073 (7), 19061289 (6), 19340314 (5), 18498068 (5) (see all 29)
epithelial tumor	45	8	15814639 (1), 15557788 (1), 18343949 (1), 18498068 (1) (see all 6)
adenocarcinoma	44.2	46	17696949 (7), 17029629 (6), 12592367 (5), 17473384 (5) (see all 15)
aggressiveness	43.5	12	19188814 (4), 17499430 (2), 16977579 (2), 18776588 (1) (see all 6)
metastasis	43.2	59	20186299 (5), 14568688 (4), 18575752 (3), 18343949 (3) (see all 28)
hodgkin disease	41.7	8	9033270 (3), 17488159 (2), 19550297 (1), 12579989 (1)
carcinoma mucinous	41	1	15626919 (1)
ovarian carcinoma	40.2	8	18776588 (2), 16620064 (1), 16620052 (1), 19245589 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: FSCN1 (1 document)

Export disorders for FSCN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FSCN1 gene, integrated from 9 sources (see all 292):
(articles sorted by number of sources associating them with FSCN1)

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cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. (PubMed id 8068206)^{1, 2, 3, 9} Duh F.-M.... Gnarra J.R. (1994)
Fascin, an actin-bundling protein, induces membrane p rotrusions and increases cell motility of epithelial cells. (PubMed id 9571235)^{1, 2, 9} Yamashiro S....Matsumura F. (1998)
Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin- bundling protein. (PubMed id 7933116)^{1, 2, 9} Mosialos G.... Birkenbach M. (1994)
Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. (PubMed id 8999969)^{1, 2, 9} Ono S.... Matsumura F. (1997)
Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PubMed id 10783262)^{1, 3, 9} Tubb B.E.... Bryan J. (2000)
Phosphorylation of human fascin inhibits its actin binding and bundling activities. (PubMed id 8647875)^{1, 2, 9} Yamakita Y.... Yamashiro S. (1996)
The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. (PubMed id 20137952)^{1, 2, 9} Li A....Machesky L.M. (2010)
Structure, evolutionary conservation, and conformatio nal dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein. (PubMed id 20434460)^{1, 2} Sedeh R.S....Bathe M. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6624	HGNC: 11148	AceView: FSCN1	Ensembl:ENSG00000075618	euGenes: HUgn6624
ECgene: FSCN1	H-InvDB: FSCN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FSCN1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FSCN1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FSCN1 gene
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FSCN1 Gene

fascin homolog 1, actin-bundling protein (Strongylocentrotus...

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FSCN1 Gene

fascin homolog 1, actin-bundling protein (Strongylocentrotus...

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