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Aliases for FSCB Gene

Aliases for FSCB Gene

  • Fibrous Sheath CABYR Binding Protein 2 3
  • C14orf155 3 4 6
  • Chromosome 14 Open Reading Frame 155 2
  • Fibrous Sheath CABYR-Binding Protein 3

External Ids for FSCB Gene

Previous Symbols for FSCB Gene

  • C14orf155

Summaries for FSCB Gene

GeneCards Summary for FSCB Gene

FSCB (Fibrous Sheath CABYR Binding Protein) is a Protein Coding gene. Diseases associated with FSCB include colorectal cancer. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for FSCB Gene

  • May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSCB Gene

Genomics for FSCB Gene

Genomic Location for FSCB Gene

Start:
44,504,149 bp from pter
End:
44,507,296 bp from pter
Size:
3,148 bases
Orientation:
Minus strand

Genomic View for FSCB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FSCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSCB Gene

Regulatory Elements for FSCB Gene

Proteins for FSCB Gene

  • Protein details for FSCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9T9-FSCB_HUMAN
    Recommended name:
    Fibrous sheath CABYR-binding protein
    Protein Accession:
    Q5H9T9
    Secondary Accessions:
    • Q5H9U7
    • Q86YI2
    • Q9H0J3

    Protein attributes for FSCB Gene

    Size:
    825 amino acids
    Molecular mass:
    87956 Da
    Quaternary structure:
    • Interacts with CABYR.
    SequenceCaution:
    • Sequence=CAB66709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FSCB Gene

Proteomics data for FSCB Gene at MOPED

Post-translational modifications for FSCB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSCB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSCB Gene

Domains for FSCB Gene

Protein Domains for FSCB Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FSCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSCB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FSCB Gene

Function for FSCB Gene

Molecular function for FSCB Gene

UniProtKB/Swiss-Prot Function: May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity).

Gene Ontology (GO) - Molecular Function for FSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FSCB: view

Phenotypes for FSCB Gene

GenomeRNAi human phenotypes for FSCB:
genes like me logo Genes that share phenotypes with FSCB: view

miRNA for FSCB Gene

miRTarBase miRNAs that target FSCB

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FSCB Gene

Localization for FSCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSCB Gene

Cell projection, cilium, flagellum. Note=Localizes to cortex of the fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSCB Gene COMPARTMENTS Subcellular localization image for FSCB gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035686 sperm fibrous sheath IEA --
GO:0097228 sperm principal piece IEA --
genes like me logo Genes that share ontologies with FSCB: view

Pathways for FSCB Gene

SuperPathways for FSCB Gene

No Data Available

Interacting Proteins for FSCB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000344579%0d%0a9606.ENSP00000432870%0d%0a
Selected Interacting proteins: ENSP00000344579 for FSCB Gene via STRING

Symbol External ID(s) Details
CABYR

Gene Ontology (GO) - Biological Process for FSCB Gene

None

No data available for Pathways by source for FSCB Gene

Compounds for FSCB Gene

(1) HMDB Compounds for FSCB Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with FSCB: view

Transcripts for FSCB Gene

mRNA/cDNA for FSCB Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSCB Gene

Fibrous sheath CABYR binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSCB Gene

No ASD Table

Relevant External Links for FSCB Gene

GeneLoc Exon Structure for
FSCB
ECgene alternative splicing isoforms for
FSCB

Expression for FSCB Gene

mRNA expression in normal human tissues for FSCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSCB Gene

This gene is overexpressed in Testis (52.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FSCB Gene

SOURCE GeneReport for Unigene cluster for FSCB Gene Hs.307086

genes like me logo Genes that share expressions with FSCB: view

No data available for mRNA Expression by UniProt/SwissProt for FSCB Gene

Orthologs for FSCB Gene

This gene was present in the common ancestor of mammals.

Orthologs for FSCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSCB 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FSCB 35
  • 72.59 (n)
  • 54.4 (a)
FSCB 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FSCB 35
  • 72.36 (n)
  • 54.13 (a)
FSCB 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fscb 16
Fscb 36
  • 29 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FSCB 36
  • 33 (a)
OneToOne
Species with no ortholog for FSCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FSCB Gene

ENSEMBL:
Gene Tree for FSCB (if available)
TreeFam:
Gene Tree for FSCB (if available)

Paralogs for FSCB Gene

Pseudogenes.org Pseudogenes for FSCB Gene

genes like me logo Genes that share paralogs with FSCB: view

No data available for Paralogs for FSCB Gene

Variants for FSCB Gene

Sequence variations from dbSNP and Humsavar for FSCB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs412408 -- 44,504,435(+) CTTCC(C/T)GCTGC utr-variant-3-prime
rs435639 -- 44,503,697(+) AATTT(C/G)ATTTT downstream-variant-500B
rs876788 -- 44,508,109(-) agcta(C/T)tgggg upstream-variant-2KB
rs991171 -- 44,508,336(+) CAAGA(A/G)GAGAA upstream-variant-2KB
rs991172 -- 44,508,344(+) GAAAA(A/T)AGACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FSCB Gene

Variant ID Type Subtype PubMed ID
nsv456254 CNV Gain 19166990
nsv901831 CNV Gain 21882294
nsv901832 CNV Loss 21882294
nsv901833 CNV Loss 21882294
nsv456273 CNV Loss 19166990

Relevant External Links for FSCB Gene

HapMap Linkage Disequilibrium report
FSCB
Human Gene Mutation Database (HGMD)
FSCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSCB Gene

Disorders for FSCB Gene

(1) MalaCards Diseases for FSCB Gene

Search for FSCB Gene in MalaCards »

Relevant External Links for FSCB

Genetic Association Database (GAD)
FSCB
genes like me logo Genes that share disorders with FSCB: view

No data available for UniProtKB/Swiss-Prot for FSCB Gene

Publications for FSCB Gene

  1. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. (PMID: 17855365) Li Y.F. … Herr J.C. (J. Biol. Chem. 2007) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3

Products for FSCB Gene

Sources for FSCB Gene

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