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FSCB Gene

protein-coding   GIFtS: 47
GCID: GC14M044973

Fibrous Sheath CABYR Binding Protein

(Previous name: chromosome 14 open reading frame 155)
(Previous symbol: C14orf155)
  Search for FSCB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibrous Sheath CABYR Binding Protein1 2
C14orf1551 2 3 5
Chromosome 14 Open Reading Frame 1551
Fibrous Sheath CABYR-Binding Protein2

External Ids:    HGNC: 204941   Entrez Gene: 840752   Ensembl: ENSG000001891397   OMIM: 6117795   UniProtKB: Q5H9T93   

Export aliases for FSCB gene to outside databases

Previous GC identifers: GC14M044044 GC14M025084


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FSCB Gene:
FSCB (fibrous sheath CABYR binding protein) is a protein-coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot: FSCB_HUMAN, Q5H9T9
Function: May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the FSCB gene promoter:
         PPAR-alpha   HSF2   AP-4   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   LCR-F1   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSCB promoter sequence
   Search Chromatin IP Primers for FSCB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FSCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.2   Ensembl cytogenetic band:  14q21.2   HGNC cytogenetic band: 14q21.3

FSCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSCB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M044973:  view genomic region     (about GC identifiers)

Start:
44,973,352 bp from pter      End:
44,976,499 bp from pter
Size:
3,148 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FSCB_HUMAN, Q5H9T9 (See protein sequence)
Recommended Name: Fibrous sheath CABYR-binding protein  
Size: 825 amino acids; 87956 Da
Subunit: Interacts with CABYR (By similarity)
Sequence caution: Sequence=CAB66709.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5H9U7 Q86YI2 Q9H0J3

Explore the universe of human proteins at neXtProt for FSCB: NX_Q5H9T9

Explore proteomics data for FSCB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FSCB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115511.3  
    ENSEMBL proteins: 
     ENSP00000344579  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5H9T9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSCB_HUMAN, Q5H9T9
    Function: May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FSCB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FSCB:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    hsa-mir-148b-3p (MIRT019418), hsa-mir-335-5p (MIRT019051)

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    1 qRT-PCR Assays for microRNA that regulate FSCB:
    hsa-miR-505
    SwitchGear 3'UTR luciferase reporter plasmidFSCB 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FSCB_HUMAN, Q5H9T9: Cell projection, cilium, flagellum (By similarity). Note=Localizes to cortex of the fibrous
    sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005929cilium IEA--

    Find genes that share ontologies with FSCB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FSCB
    Interactions:

        Search GeneGlobe Interaction Network for FSCB

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FSCB (ENSP000003445794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP3ENSP000002288504STRING: ENSP00000228850
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018105peptidyl-serine phosphorylation IEA--

    Find genes that share ontologies with FSCB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FSCB

    1 HMDB Compound for FSCB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FSCB gene: 
    NM_032135.3  

    Unigene Cluster for FSCB:

    Fibrous sheath CABYR binding protein
    Hs.307086  [show with all ESTs]
    Unigene Representative Sequence: NM_032135
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340446(uc001wvn.3)
    miRNA
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    hsa-miR-505
    SwitchGear 3'UTR luciferase reporter plasmidFSCB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK124110.1 AK302615.1 AL136775.1 BC039878.1 CR933608.1 CR933626.1 

    3 DOTS entries:

    DT.101977669  DT.91673294  DT.100741357 

    3 AceView cDNA sequences:

    NM_032135 BC039878 AL136775 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FSCB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAGTACA
    FSCB Expression
    About this image


    FSCB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Mature Sertoli Cells Seminiferous Tubules
    FSCB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FSCB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.307086
        Custom PCR Arrays for FSCB
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FSCB gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fscb5 fibrous sheath CABYR binding protein   --   12 (26.96 cM) 64471333 


    ENSEMBL Gene Tree for FSCB (if available)
    TreeFam Gene Tree for FSCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FSCB gene

    Find genes that share paralogs with FSCB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FSCB
    PGOHUM00000234953


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FSCB (see all 227)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356784
    A breast cancer sample4--see VAR_0356782 T R mis40--------
    VAR_0356804
    A breast cancer sample4--see VAR_0356802 S L mis40--------
    VAR_0356794
    A breast cancer sample4--see VAR_0356792 Q K mis40--------
    rs4356391,2
    C,F,O,A--44972900(+) AATTTG/CATTTT 1 -- int113Minor allele frequency- C:0.46EA NA WA CSA 581
    rs1915420811,2
    --44972961(+) AACTTC/TCCAAG 1 -- int10--------
    rs1500273801,2
    --44973053(+) TTTATG/TTGCAC 1 -- int10--------
    rs1443500641,2
    --44973123(+) AGAAAC/TAAGGT 1 -- int10--------
    rs789317231,2
    C,F--44973348(+) GACATT/CGGCTT 1 -- int12Minor allele frequency- C:0.09CSA WA 120
    rs2007906821,2
    C--44973380(+) ACTTA-/AAAGGG 1 -- ut310--------
    rs754282921,2
    C,F--44973428(+) TTACTC/TGTGTC 1 -- ut312Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for FSCB (44973352 - 44976499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FSCB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv456273CNV Loss19166990
    nsv901832CNV Loss21882294
    nsv901833CNV Loss21882294
    nsv456254CNV Gain19166990
    nsv901831CNV Gain21882294

    Human Gene Mutation Database (HGMD): FSCB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FSCB
    DNA2.0 Custom Variant and Variant Library Synthesis for FSCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611779    OMIM disorders: --


    Find genes that share disorders with FSCB           About GenesLikeMe

    Genetic Association Database (GAD): FSCB

    Export disorders for FSCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FSCB gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FSCB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. (PubMed id 17855365)1, 3 Li Y.F....Herr J.C. (J. Biol. Chem. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    7. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    8. A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. (PubMed id 17903305)4 Murabito J.M....Hwang S.J. (BMC Med. Genet. 2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84075 HGNC: 20494 AceView: C14orf155 Ensembl:ENSG00000189139 euGenes: HUgn84075
    ECgene: FSCB H-InvDB: FSCB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FSCB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FSCB gene:
    Search GeneIP for patents involving FSCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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