FSCB Gene
protein-coding GIFtS: 43
GCID: GC14M044973
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fibrous sheath CABYR binding protein(Previous name: chromosome 14 open reading frame 155 )
(Previous symbol: C14orf155)
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Aliases
for FSCB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibrous Sheath CABYR Binding Protein1 2 | | C14orf1551 2 3 5 | | DKFZP434F10171 | | Chromosome 14 Open Reading Frame 1551 | | Fibrous Sheath CABYR-Binding Protein2 |
Export aliases for FSCB gene to outside databasesPrevious GC identifers: GC14M044044 GC14M025084 |
Summaries
for FSCB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FSCB_HUMAN, Q5H9T9Function: May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity)
|
Genomic Views
for FSCB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FSCB gene promoter:
PPAR-alpha HSF2 AP-4 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) LCR-F1 POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FSCB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSCB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q21.2 Ensembl cytogenetic band: 14q21.2 HGNC cytogenetic band: 14q21.3FSCB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M044973: view genomic region
(about GC identifiers)
Start:
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44,973,352 bp from pter |
End:
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44,976,499 bp from pter |
Size:
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3,148 bases |
Orientation:
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minus strand |
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Proteins
for FSCB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FSCB_HUMAN, Q5H9T9 (See
protein sequence)Recommended Name: Fibrous sheath CABYR-binding protein Size: 825 amino acids; 87956 Da
Subunit: Interacts with CABYR (By similarity)
Subcellular location: Cell projection, cilium, flagellum (By similarity). Note=Localizes to cortex of the fibroussheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella (Bysimilarity)
Sequence caution: Sequence=CAB66709.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5H9U7 Q86YI2 Q9H0J3Explore the universe of human proteins at neXtProt for FSCB: NX_Q5H9T9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5H9T9
FSCB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115511.3
ENSEMBL proteins: ENSP00000344579
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005929 | cilium |
IEA | -- |
FSCB for ontologies About GeneDecksing
FSCB Antibody Products:
Assay Products for FSCB: |
Protein
Domains /
Families
for FSCB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5H9T9 |
Function
for FSCB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FSCB_HUMAN, Q5H9T9Function: May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSCB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSCB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FSCB (NM_032135) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FSCB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCB |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
FSCB for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FSCB:
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Pathways & Interactions
for FSCB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSCB
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FSCB (ENSP000003445794) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018105 | peptidyl-serine phosphorylation |
IEA | -- |
FSCB for ontologies About GeneDecksing
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Drugs & Compounds
for FSCB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FSCB
1 HMDB Compound for FSCB About this table
Search CenterWatch for drugs/clinical trials and news about FSCB
|
Transcripts
for FSCB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FSCB gene: NM_032135.3 Unigene Cluster for FSCB: Fibrous sheath CABYR binding protein Hs.307086 [show with all ESTs]Unigene Representative Sequence: NM_0321351 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000340446(uc001wvn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSCB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSCB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FSCB (NM_032135) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FSCB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCB |
Additional cDNA sequence: AK124110.1 AK302615.1 AL136775.1 BC039878.1 CR933608.1 CR933626.1 3 DOTS entries: DT.101977669 DT.91673294 DT.100741357 3 AceView cDNA sequences: NM_032135 BC039878 AL136775
GeneLoc Exon Structure
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Expression
for FSCB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FSCB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAAGTACA
About this image
See FSCB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FSCB
SOURCE GeneReport for Unigene cluster: Hs.307086
SABiosciences Custom PCR Arrays for FSCB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSCB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FSCB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSCB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSCB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCB |
Orthologs
for FSCB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FSCB gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for FSCB (if available)
TreeFam Gene Tree for FSCB (if available) |
Paralogs
for FSCB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FSCB gene
- KIAA07542
FSCB for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FSCB
PGOHUM00000234953
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Genomic Variants
for FSCB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FSCB (44973352 - 44976499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FSCB: --
Human Gene Mutation Database (HGMD): FSCB
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSCB |
|
Disorders
/ Diseases
for FSCB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FSCB for disorders About GeneDecksing
OMIM gene information: 611779
OMIM disorders: --
1  disease for FSCB: About MalaCardsmalaria
Export disorders for FSCB gene to outside databases
|
Publications
for FSCB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FSCB gene integrated from 9 sources:
(articles sorted by number of sources associating them with FSCB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. (PubMed id 17855365)1, 3 Li Y.F....Herr J.C. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
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External Searches for FSCB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FSCB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FSCB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FSCB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FSCB | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FSCB gene:
Search GeneIP for patents involving FSCB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FSCB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FSCB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FSCB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FSCB | | | OriGene Protein Over-expression Lysate for FSCB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FSCB | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FSCB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FSCB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FSCB | | OriGene Custom Protein Services for FSCB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FSCB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSCB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSCB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSCB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSCB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSCB |
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 |  |  |  | |
| | | | Search Tocris compounds for FSCB |
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 | | | FSCB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCB |
|  |  |  | | | | Search ThermoFisher Antibodies for FSCB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCB |
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