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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FSCB Gene

protein-coding   GIFtS: 44
GCID: GC14M044973

Fibrous Sheath CABYR Binding Protein

(Previous name: chromosome 14 open reading frame 155)
(Previous symbol: C14orf155)
  Search for FSCB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibrous Sheath CABYR Binding Protein1 2
C14orf1551 2 3 5
Chromosome 14 Open Reading Frame 1551
Fibrous Sheath CABYR-Binding Protein2

External Ids:    HGNC: 204941   Entrez Gene: 840752   Ensembl: ENSG000001891397   OMIM: 6117795   UniProtKB: Q5H9T93   

Export aliases for FSCB gene to outside databases

Previous GC identifers: GC14M044044 GC14M025084


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FSCB Gene: 
FSCB (fibrous sheath CABYR binding protein) is a protein-coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot: FSCB_HUMAN, Q5H9T9
Function: May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FSCB gene promoter:
         PPAR-alpha   HSF2   AP-4   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   LCR-F1   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFSCB promoter sequence
   Search SABiosciences Chromatin IP Primers for FSCB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.2   Ensembl cytogenetic band:  14q21.2   HGNC cytogenetic band: 14q21.3

FSCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSCB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M044973:  view genomic region     (about GC identifiers)

Start:
44,973,352 bp from pter      End:
44,976,499 bp from pter
Size:
3,148 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FSCB_HUMAN, Q5H9T9 (See protein sequence)
Recommended Name: Fibrous sheath CABYR-binding protein  
Size: 825 amino acids; 87956 Da
Subunit: Interacts with CABYR (By similarity)
Subcellular location: Cell projection, cilium, flagellum (By similarity). Note=Localizes to cortex of the fibrous
sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella (By
similarity)
Sequence caution: Sequence=CAB66709.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5H9U7 Q86YI2 Q9H0J3

Explore the universe of human proteins at neXtProt for FSCB: NX_Q5H9T9

Explore proteomics data for FSCB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5H9T9

  • FSCB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FSCB Protein Expression
    REFSEQ proteins: NP_115511.3  
    ENSEMBL proteins: 
     ENSP00000344579  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005929cilium IEA--
    GO:0044441cilium part ----

    FSCB for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5H9T9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSCB_HUMAN, Q5H9T9
    Function: May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    FSCB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FSCB:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FSCB 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSCB

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FSCB (ENSP000003445794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP3ENSP000002288504STRING: ENSP00000228850
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018105peptidyl-serine phosphorylation IEA--

    FSCB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FSCB

    1 HMDB Compound for FSCB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about FSCB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FSCB gene: 
    NM_032135.3  

    Unigene Cluster for FSCB:

    Fibrous sheath CABYR binding protein
    Hs.307086  [show with all ESTs]
    Unigene Representative Sequence: NM_032135
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340446(uc001wvn.3)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FSCB:
    hsa-miR-505
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    Inhib. RNA
    Products:
         
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FSCB
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                         Customized lentivirus expression plasmids for stable overexpression of FSCB 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSCB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSCB

    Additional mRNA sequence: 

    AK124110.1 AK302615.1 AL136775.1 BC039878.1 CR933608.1 CR933626.1 

    3 DOTS entries:

    DT.101977669  DT.91673294  DT.100741357 

    3 AceView cDNA sequences:

    BC039878 NM_032135 AL136775 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FSCB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAGTACA
    FSCB Expression
    About this image


    See FSCB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FSCB

    SOURCE GeneReport for Unigene cluster: Hs.307086
        SABiosciences Custom PCR Arrays for FSCB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FSCB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FSCB gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fscb1 , 5 fibrous sheath CABYR binding protein1, 5 65.96(n)1
    48.94(a)1
      12 (26.96 cM)5
    6230461  NM_001163271.11  NP_001156743.11 
     644713335 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-39i22.16
    si:ch211-140m22.76
    (see all 4)
    si:ch211-140m22.7
    (see all 4)
    19(a)
    17(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    9(57815819-57860967)
    9(20377209-20398561)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120096
    CG100146
    (see all 4)
    --
    9(a)
    15(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    3L(3291459-3299000)
    3R(8048109-8049770)
    worm
    (Caenorhabditis elegans)
    Secernentea F49E2.56
    F35A5.16
    (see all 5)
    --
    7(a)
    4(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    X(9543670-9560316)
    X(3807466-3816434)


    ENSEMBL Gene Tree for FSCB (if available)
    TreeFam Gene Tree for FSCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FSCB gene

    FSCB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FSCB
    PGOHUM00000234953


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 SNPs in FSCB are shown (see all 227)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356784
    A breast cancer sample4--see VAR_0356782 T R mis40--------
    VAR_0356804
    A breast cancer sample4--see VAR_0356802 S L mis40--------
    VAR_0356794
    A breast cancer sample4--see VAR_0356792 Q K mis40--------
    rs4356391,2
    C,F,O,A--44972900(+) AATTTG/CATTTT 1 -- int113Minor allele frequency- C:0.46EA NA WA CSA 581
    rs1915420811,2
    --44972961(+) AACTTC/TCCAAG 1 -- int10--------
    rs1500273801,2
    --44973053(+) TTTATG/TTGCAC 1 -- int10--------
    rs1443500641,2
    --44973123(+) AGAAAC/TAAGGT 1 -- int10--------
    rs789317231,2
    C,F--44973348(+) GACATT/CGGCTT 1 -- int12Minor allele frequency- C:0.09CSA WA 120
    rs2007906821,2
    C--44973380(+) ACTTA-/AAAGGG 1 -- ut310--------
    rs754282921,2
    C,F--44973428(+) TTACTC/TGTGTC 1 -- ut312Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for FSCB (44973352 - 44976499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FSCB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv456273CNV Loss19166990
    nsv901832CNV Loss21882294
    nsv901833CNV Loss21882294
    nsv456254CNV Gain19166990
    nsv901831CNV Gain21882294


    Human Gene Mutation Database (HGMD): FSCB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FSCB
    DNA2.0 Custom Variant and Variant Library Synthesis for FSCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FSCB for disorders           About MalaCards
    OMIM gene information: 611779    OMIM disorders: --


    FSCB for disorders           About GeneDecksing

    Genetic Association Database (GAD): FSCB

    Export disorders for FSCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FSCB gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with FSCB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. (PubMed id 17855365)1, 3 Li Y.F....Herr J.C. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (2007)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    7. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (2007)
    8. A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. (PubMed id 17903305)4 Murabito J.M....Hwang S.J. (2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84075 HGNC: 20494 AceView: C14orf155 Ensembl:ENSG00000189139 euGenes: HUgn84075
    ECgene: FSCB H-InvDB: FSCB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FSCB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FSCB gene:
    Search GeneIP for patents involving FSCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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