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Aliases for FSCB Gene

Aliases for FSCB Gene

  • Fibrous Sheath CABYR Binding Protein 2 3 5
  • C14orf155 3 4
  • Chromosome 14 Open Reading Frame 155 2
  • Fibrous Sheath CABYR-Binding Protein 3

External Ids for FSCB Gene

Previous HGNC Symbols for FSCB Gene

  • C14orf155

Previous GeneCards Identifiers for FSCB Gene

  • GC14M044044
  • GC14M044973
  • GC14M025084

Summaries for FSCB Gene

GeneCards Summary for FSCB Gene

FSCB (Fibrous Sheath CABYR Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for FSCB Gene

  • May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.

Additional gene information for FSCB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSCB Gene

Genomics for FSCB Gene

GeneHancer (GH) Regulatory Elements for FSCB Gene

Promoters and enhancers for FSCB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I044507 Promoter 0.7 EPDnew 550.8 0.0 -7 0.1 CREB1 ATF7 ATF2 LOC105370473 FSCB GC14P044463 GC14P044464 GC14P044465 GC14P044468 GC14P044469 GC14P044470 GC14P044471 GC14P044472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FSCB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FSCB gene promoter:

Genomic Locations for FSCB Gene

Genomic Locations for FSCB Gene
3,148 bases
Minus strand

Genomic View for FSCB Gene

Genes around FSCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSCB Gene

Proteins for FSCB Gene

  • Protein details for FSCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrous sheath CABYR-binding protein
    Protein Accession:
    Secondary Accessions:
    • Q5H9U7
    • Q86YI2
    • Q9H0J3

    Protein attributes for FSCB Gene

    825 amino acids
    Molecular mass:
    87956 Da
    Quaternary structure:
    • Interacts with CABYR. Interacts with ROPN1 and ROPN1L; the interaction increases upon spermatozoa capacitation conditions.
    • Sequence=CAB66709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FSCB Gene

Post-translational modifications for FSCB Gene

Other Protein References for FSCB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSCB Gene

Domains & Families for FSCB Gene

Gene Families for FSCB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FSCB Gene


Suggested Antigen Peptide Sequences for FSCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSCB: view

No data available for UniProtKB/Swiss-Prot for FSCB Gene

Function for FSCB Gene

Molecular function for FSCB Gene

UniProtKB/Swiss-Prot Function:
May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.

Phenotypes From GWAS Catalog for FSCB Gene

genes like me logo Genes that share phenotypes with FSCB: view

miRNA for FSCB Gene

miRTarBase miRNAs that target FSCB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSCB Gene

Localization for FSCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSCB Gene

Cell projection, cilium, flagellum. Note=Localizes to cortex of the fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella. {ECO:0000250 UniProtKB:A1EGX6}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSCB gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031514 motile cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with FSCB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FSCB Gene

Pathways & Interactions for FSCB Gene

No Data Available

Interacting Proteins for FSCB Gene

Gene Ontology (GO) - Biological Process for FSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033234 negative regulation of protein sumoylation ISS --
genes like me logo Genes that share ontologies with FSCB: view

No data available for Pathways by source and SIGNOR curated interactions for FSCB Gene

Drugs & Compounds for FSCB Gene

(1) Drugs for FSCB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with FSCB: view

Transcripts for FSCB Gene

mRNA/cDNA for FSCB Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSCB Gene

Fibrous sheath CABYR binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSCB Gene

No ASD Table

Relevant External Links for FSCB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSCB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSCB Gene

mRNA differential expression in normal tissues according to GTEx for FSCB Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for FSCB Gene

This gene is overexpressed in Liver, secretome (36.7), Pancreas (10.4), and Adrenal (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSCB Gene

NURSA nuclear receptor signaling pathways regulating expression of FSCB Gene:


SOURCE GeneReport for Unigene cluster for FSCB Gene:


Evidence on tissue expression from TISSUES for FSCB Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FSCB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSCB Gene

Orthologs for FSCB Gene

This gene was present in the common ancestor of mammals.

Orthologs for FSCB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FSCB 34
  • 95 (a)
(Bos Taurus)
Mammalia FSCB 33 34
  • 72.59 (n)
(Canis familiaris)
Mammalia FSCB 33 34
  • 72.36 (n)
(Monodelphis domestica)
Mammalia FSCB 34
  • 33 (a)
(Mus musculus)
Mammalia Fscb 34
  • 29 (a)
Species where no ortholog for FSCB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FSCB Gene

Gene Tree for FSCB (if available)
Gene Tree for FSCB (if available)

Paralogs for FSCB Gene Pseudogenes for FSCB Gene

genes like me logo Genes that share paralogs with FSCB: view

No data available for Paralogs for FSCB Gene

Variants for FSCB Gene

Sequence variations from dbSNP and Humsavar for FSCB Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs201017166 A breast cancer sample 44,504,664(-) G/A/C/T coding_sequence_variant, missense_variant, stop_gained
VAR_035678 A breast cancer sample p.Thr262Arg
VAR_035679 A breast cancer sample p.Gln764Lys
rs1000733264 -- 44,506,540(-) T/C coding_sequence_variant, missense_variant
rs1001178044 -- 44,507,092(-) T/G 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FSCB Gene

Variant ID Type Subtype PubMed ID
esv3634329 CNV loss 21293372
esv3634330 CNV gain 21293372
esv3892524 CNV loss 25118596
nsv1051850 CNV loss 25217958
nsv456254 CNV gain 19166990
nsv456273 CNV loss 19166990
nsv564642 CNV loss 21841781
nsv564651 CNV gain 21841781
nsv564681 CNV loss 21841781
nsv564694 CNV loss 21841781

Variation tolerance for FSCB Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FSCB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSCB Gene

Disorders for FSCB Gene

Additional Disease Information for FSCB

No disorders were found for FSCB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSCB Gene

Publications for FSCB Gene

  1. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. (PMID: 17855365) Li YF … Herr JC (The Journal of biological chemistry 2007) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  5. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 44 58

Products for FSCB Gene

Sources for FSCB Gene

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