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Aliases for FSCB Gene

Aliases for FSCB Gene

  • Fibrous Sheath CABYR Binding Protein 2 3 5
  • C14orf155 3 4
  • Chromosome 14 Open Reading Frame 155 2

External Ids for FSCB Gene

Previous HGNC Symbols for FSCB Gene

  • C14orf155

Previous GeneCards Identifiers for FSCB Gene

  • GC14M044044
  • GC14M044973
  • GC14M025084

Summaries for FSCB Gene

GeneCards Summary for FSCB Gene

FSCB (Fibrous Sheath CABYR Binding Protein) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for FSCB Gene

  • May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSCB Gene

Genomics for FSCB Gene

Regulatory Elements for FSCB Gene

Genomic Location for FSCB Gene

Chromosome:
14
Start:
44,504,149 bp from pter
End:
44,507,296 bp from pter
Size:
3,148 bases
Orientation:
Minus strand

Genomic View for FSCB Gene

Genes around FSCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSCB Gene

Proteins for FSCB Gene

  • Protein details for FSCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9T9-FSCB_HUMAN
    Recommended name:
    Fibrous sheath CABYR-binding protein
    Protein Accession:
    Q5H9T9
    Secondary Accessions:
    • Q5H9U7
    • Q86YI2
    • Q9H0J3

    Protein attributes for FSCB Gene

    Size:
    825 amino acids
    Molecular mass:
    87956 Da
    Quaternary structure:
    • Interacts with CABYR.
    SequenceCaution:
    • Sequence=CAB66709.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FSCB Gene

Proteomics data for FSCB Gene at MOPED

Post-translational modifications for FSCB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSCB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSCB Gene

Domains & Families for FSCB Gene

Protein Domains for FSCB Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FSCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSCB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FSCB Gene

Function for FSCB Gene

Molecular function for FSCB Gene

UniProtKB/Swiss-Prot Function:
May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity).
genes like me logo Genes that share phenotypes with FSCB: view

Animal Model Products

CRISPR Products

miRNA for FSCB Gene

miRTarBase miRNAs that target FSCB

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSCB Gene

Localization for FSCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSCB Gene

Cell projection, cilium, flagellum. Note=Localizes to cortex of the fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FSCB Gene COMPARTMENTS Subcellular localization image for FSCB gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for FSCB Gene

Pathways & Interactions for FSCB Gene

SuperPathways for FSCB Gene

No Data Available

Interacting Proteins for FSCB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000344579%0d%0a9606.ENSP00000432870%0d%0a
Selected Interacting proteins: ENSP00000344579 for FSCB Gene via STRING

Symbol External ID(s) Details
CABYR

Gene Ontology (GO) - Biological Process for FSCB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FSCB Gene

Drugs & Compounds for FSCB Gene

(1) Drugs for FSCB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with FSCB: view

Transcripts for FSCB Gene

mRNA/cDNA for FSCB Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSCB Gene

Fibrous sheath CABYR binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSCB Gene

No ASD Table

Relevant External Links for FSCB Gene

GeneLoc Exon Structure for
FSCB
ECgene alternative splicing isoforms for
FSCB

Expression for FSCB Gene

mRNA expression in normal human tissues for FSCB Gene

mRNA differential expression in normal tissues according to GTEx for FSCB Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for FSCB Gene

This gene is overexpressed in Liver, secretome (36.7), Pancreas (10.4), and Adrenal (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSCB Gene



SOURCE GeneReport for Unigene cluster for FSCB Gene Hs.307086

genes like me logo Genes that share expression patterns with FSCB: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FSCB Gene

Orthologs for FSCB Gene

This gene was present in the common ancestor of mammals.

Orthologs for FSCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSCB 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FSCB 36
  • 49 (a)
OneToOne
FSCB 35
  • 72.59 (n)
  • 54.4 (a)
dog
(Canis familiaris)
Mammalia FSCB 35
  • 72.36 (n)
  • 54.13 (a)
FSCB 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fscb 36
  • 29 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FSCB 36
  • 33 (a)
OneToOne
Species with no ortholog for FSCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FSCB Gene

ENSEMBL:
Gene Tree for FSCB (if available)
TreeFam:
Gene Tree for FSCB (if available)

Paralogs for FSCB Gene

Pseudogenes.org Pseudogenes for FSCB Gene

genes like me logo Genes that share paralogs with FSCB: view

No data available for Paralogs for FSCB Gene

Variants for FSCB Gene

Sequence variations from dbSNP and Humsavar for FSCB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035678 A breast cancer sample
VAR_035679 A breast cancer sample
VAR_035680 A breast cancer sample
VAR_056874 -
VAR_056875 -

Structural Variations from Database of Genomic Variants (DGV) for FSCB Gene

Variant ID Type Subtype PubMed ID
nsv456254 CNV Gain 19166990
nsv901831 CNV Gain 21882294
nsv901832 CNV Loss 21882294
nsv901833 CNV Loss 21882294
nsv456273 CNV Loss 19166990

Variation tolerance for FSCB Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSCB Gene

HapMap Linkage Disequilibrium report
FSCB
Human Gene Mutation Database (HGMD)
FSCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSCB Gene

Disorders for FSCB Gene

Relevant External Links for FSCB

Genetic Association Database (GAD)
FSCB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSCB

No disorders were found for FSCB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSCB Gene

Publications for FSCB Gene

  1. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. (PMID: 17855365) Li Y.F. … Herr J.C. (J. Biol. Chem. 2007) 2 3 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for FSCB Gene

Sources for FSCB Gene

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