FSBP Gene
protein-coding GIFtS: 23
GCID: GC08M095400
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fibrinogen silencer binding protein
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Aliases
for FSBP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibrinogen Silencer Binding Protein1 2 | | Fibrinogen Silencer-Binding Protein2 |
Export aliases for FSBP gene to outside databasesPrevious GC identifers: GC08U990078 GC08M095231 GC08M095112 GC08M095341 GC08M095513 |
Summaries
for FSBP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FSBP_HUMAN, O95073Function: Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Repressestranscription of GSK3B gene promoter via its interaction with APBA1
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Genomic Views
for FSBP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FSBP
Other transcription factors
Search SABiosciences Chromatin IP Primers for FSBP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSBP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1FSBP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M095400: view genomic region
(about GC identifiers)
Start:
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95,390,605 bp from pter |
End:
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95,449,180 bp from pter |
Size:
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58,576 bases |
Orientation:
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minus strand |
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Proteins
for FSBP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FSBP_HUMAN, O95073 (See
protein sequence)Recommended Name: Fibrinogen silencer-binding protein Size: 299 amino acids; 34768 Da
Subunit: Interacts with APBA1 (via PDZ 1 and 2 domains)
Subcellular location: Nucleus
Miscellaneous: Intragenic, in the second intron of RAB54B gene
Secondary accessions: Q8N4S5Alternative splicing: 2 isoforms: O95073-1 O95073-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FSBP: NX_O95073
FSBP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001243070.1
ENSEMBL proteins: ENSP00000462684 ENSP00000420405
Human Recombinant Protein Products for FSBP:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
FSBP for ontologies About GeneDecksing
FSBP Antibody Products:
Assay Products for FSBP: |
Protein
Domains /
Families
for FSBP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O95073 |
Function
for FSBP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FSBP_HUMAN, O95073Function: Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Repressestranscription of GSK3B gene promoter via its interaction with APBA1 Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
FSBP for ontologies About GeneDecksing
Animal Models:
|
Pathways & Interactions
for FSBP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FSBP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/18 Interacting proteins for FSBP (O950733 ENSP000004204054) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
FSBP for ontologies About GeneDecksing
|
Drugs & Compounds
for FSBP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FSBP
Search CenterWatch for drugs/clinical trials and news about FSBP 
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Transcripts
for FSBP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FSBP gene: NM_001256141.1 Unigene Cluster for FSBP: Fibrinogen silencer binding protein Hs.30561 [show with all ESTs]Unigene Representative Sequence: NM_0012561412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000517506 ENST00000481490(uc003ygm.2)
Additional cDNA sequence: AF007866.1 AK074272.1 3 DOTS entries: DT.105675 DT.91754078 DT.102836258
GeneLoc Exon Structure
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Expression
for FSBP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FSBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTTTAAA
About this image
See FSBP Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.30561
UniProtKB/Swiss-Prot: FSBP_HUMAN, O95073Tissue specificity: Expressed in multiple tissues including brain
SABiosciences Custom PCR Arrays for FSBP
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FSBP | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSBP | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSBP |
Orthologs
for FSBP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FSBP gene from 2/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FSBP6 |
Uncharacterized protein |
78(a) |
1 ↔ 1 |
2(130864756-130870110) |
lizard
(Anolis carolinensis) |
Reptilia |
FSBP6 |
-- |
76(a) |
1 ↔ 1 |
4(19002409-19008734) |
Species with no ortholog for FSBP
ENSEMBL Gene Tree for FSBP (if available)
TreeFam Gene Tree for FSBP (if available) |
Paralogs
for FSBP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FSBP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for FSBP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FSBP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FSBP gene integrated from 9 sources:
(articles sorted by number of sources associating them with FSBP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An X11alpha/FSBP complex represses transcription of t he GSK3beta gene promoter. (PubMed id 20531236)1, 2, 3 Lau K.F....Miller C.C. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for FSBP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FSBP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FSBP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FSBP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| SeattleSNPs | http://pga.gs.washington.edu/data/fsbp/ |
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About This Section
| Patent Information for FSBP gene:
Search GeneIP for patents involving FSBP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FSBP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FSBP | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FSBP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FSBP | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FSBP | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FSBP | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FSBP |
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 |  |  |  | |
| | | | Search Tocris compounds for FSBP |
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 | | | FSBP Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for FSBP |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FSBP |
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