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FSBP Gene

protein-coding   GIFtS: 31
GCID: GC08M095400

Fibrinogen Silencer Binding Protein

  Search for FSBP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibrinogen Silencer Binding Protein1 2
Fibrinogen Silencer-Binding Protein2

External Ids:    HGNC: 436531   Entrez Gene: 1008614122   Ensembl: ENSG000002658177   UniProtKB: O950733   

Export aliases for FSBP gene to outside databases

Previous GC identifers: GC08U990078 GC08M095231 GC08M095112 GC08M095341 GC08M095513


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FSBP Gene:
FSBP (fibrinogen silencer binding protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: FSBP_HUMAN, O95073
Function: Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses
transcription of GSK3B gene promoter via its interaction with APBA1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FSBP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FSBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FSBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

FSBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FSBP gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095400:  view genomic region     (about GC identifiers)

Start:
95,390,605 bp from pter      End:
95,449,180 bp from pter
Size:
58,576 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FSBP_HUMAN, O95073 (See protein sequence)
Recommended Name: Fibrinogen silencer-binding protein  
Size: 299 amino acids; 34768 Da
Subunit: Interacts with APBA1 (via PDZ 1 and 2 domains)
Miscellaneous: Intragenic, in the second intron of RAB54B gene
Secondary accessions: Q8N4S5
Alternative splicing: 2 isoforms:  O95073-1   O95073-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FSBP: NX_O95073

Explore proteomics data for FSBP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15

  • See FSBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001243070.1  
    ENSEMBL proteins: 
     ENSP00000462684   ENSP00000420405  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028002 Myb_DNA-bind_5

    Graphical View of Domain Structure for InterPro Entry O95073

    ProtoNet protein and cluster: O95073


    Find genes that share domains with FSBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FSBP_HUMAN, O95073
    Function: Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses
    transcription of GSK3B gene promoter via its interaction with APBA1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with FSBP           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FSBP_HUMAN, O95073: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    Find genes that share ontologies with FSBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FSBP About    
    See pathways by source

    SuperPathContained pathways About
    1Homologous recombination
    Homologous recombination0.40


    1 BioSystems Pathway for FSBP
        Homologous recombination


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FSBP
    Interactions:

        Search GeneGlobe Interaction Network for FSBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for FSBP (O950733 ENSP000004204054) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NIF3L1Q9GZT83, ENSP000003863944I2D: score=1 STRING: ENSP00000386394
    NUDT18Q6ZVK83, ENSP000003078524I2D: score=1 STRING: ENSP00000307852
    TCEB3Q142413, ENSP000003955744I2D: score=1 STRING: ENSP00000395574
    CD2BP2O954003, ENSP000003049034I2D: score=1 STRING: ENSP00000304903
    PSMA1P257863I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with FSBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FSBP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FSBP gene: 
    NM_001256141.1  

    Unigene Cluster for FSBP:

    Fibrinogen silencer binding protein
    Hs.30561  [show with all ESTs]
    Unigene Representative Sequence: NM_001256141
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517506 ENST00000481490(uc003ygm.2)
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    Additional mRNA sequence: 

    AF007866.1 AK074272.1 

    3 DOTS entries:

    DT.105675  DT.91754078  DT.102836258 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FSBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTTTAAA
    FSBP Expression
    About this image

    FSBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FSBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.30561

    UniProtKB/Swiss-Prot: FSBP_HUMAN, O95073
    Tissue specificity: Expressed in multiple tissues including brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FSBP gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fsbp1 fibrinogen silencer binding protein 89.07(n)
    87.96(a)
      100503583  NM_001256142.1  NP_001243071.1 
    chicken
    (Gallus gallus)
    Aves FSBP1 fibrinogen silencer binding protein 77.14(n)
    78.38(a)
      770634  XM_001233121.3  XP_001233122.1 
    lizard
    (Anolis carolinensis)
    Reptilia FSBP6
    fibrinogen silencer binding protein
    77(a)
    1 ↔ 1
    4(19002409-19008734)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fsbp1 fibrinogen silencer binding protein 63.97(n)
    57.91(a)
      101733687  XM_004915146.1  XP_004915203.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018848261 fibrinogen silencer-binding protein-like 59.67(n)
    56.23(a)
      101884826  XM_005158036.1  XP_005158093.1 


    ENSEMBL Gene Tree for FSBP (if available)
    TreeFam Gene Tree for FSBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for FSBP    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31364221,2,4
    ----see VAR_0193012 mis40--------

    HapMap Linkage Disequilibrium report for FSBP (95390605 - 95449180 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FSBP: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FSBP
    DNA2.0 Custom Variant and Variant Library Synthesis for FSBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FSBP gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FSBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. (PubMed id 20531236)1, 2, 3 Lau K.F.... Miller C.C. (NeuroReport 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100861412 HGNC: 43653 Ensembl:ENSG00000265817 euGenes: HUgn100861412 ECgene: FSBP
    H-InvDB: FSBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FSBP Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/fsbp/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FSBP gene:
    Search GeneIP for patents involving FSBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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