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Aliases for FSBP Gene

Aliases for FSBP Gene

  • Fibrinogen Silencer Binding Protein 2 3 5

External Ids for FSBP Gene

Previous GeneCards Identifiers for FSBP Gene

  • GC08U990078
  • GC08M095231
  • GC08M095112
  • GC08M095341
  • GC08M095400
  • GC08M095513

Summaries for FSBP Gene

GeneCards Summary for FSBP Gene

FSBP (Fibrinogen Silencer Binding Protein) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is RAD54B.

UniProtKB/Swiss-Prot for FSBP Gene

  • Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSBP Gene

Genomics for FSBP Gene

Regulatory Elements for FSBP Gene

Enhancers for FSBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G094439 1.2 Ensembl ENCODE 6.5 -4.0 -3998 2.1 PKNOX1 MLX ARID4B SIN3A DMAP1 TCF12 GATA2 ZNF143 ZNF207 MXD4 RAD54B FSBP GC08M094432 GC08P094456
GH08G093900 1.3 Ensembl ENCODE dbSUPER 5.9 +533.1 533085 6.7 PKNOX1 TBL1XR1 ZNF766 CBX5 FOS RELB IKZF2 CEBPB TBX21 ZNF589 PDP1 LINC00535 FAM92A FSBP LOC105375646 GC08M093861
GH08G093696 0.7 ENCODE 10.4 +740.1 740115 0.8 PKNOX1 ZFP64 ZNF140 ZNF426 ZNF394 ZBTB8A ZNF623 ZNF781 ATF2 ZNF518A RBM12B VIRMA ENSG00000271971 LOC105375645 FAM92A ENSG00000253722 FSBP ENSG00000253854 PIR47593
GH08G094058 1.1 Ensembl ENCODE 5 +377.3 377334 1.7 PKNOX1 ATF1 SIN3A ZBTB7B RAD21 YY1 RFX5 GATA2 RCOR1 FOS ENSG00000253585 FSBP GC08M094039
GH08G094467 0.8 Ensembl ENCODE 6 -31.2 -31235 1.5 JUND GATA2 ZBTB33 FOS MAFK VIRMA FSBP RAD54B GC08P094456
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FSBP on UCSC Golden Path with GeneCards custom track

Promoters for FSBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227197 1051 2200 TBP NFRKB WRNIP1 ZBTB40 YY1 IKZF2 SMARCB1 POLR2H PRDM6 SMARCA4

Genomic Location for FSBP Gene

Chromosome:
8
Start:
94,372,170 bp from pter
End:
94,436,952 bp from pter
Size:
64,783 bases
Orientation:
Minus strand

Genomic View for FSBP Gene

Genes around FSBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSBP Gene

Proteins for FSBP Gene

  • Protein details for FSBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95073-FSBP_HUMAN
    Recommended name:
    Fibrinogen silencer-binding protein
    Protein Accession:
    O95073
    Secondary Accessions:
    • Q8N4S5

    Protein attributes for FSBP Gene

    Size:
    299 amino acids
    Molecular mass:
    34768 Da
    Quaternary structure:
    • Interacts with APBA1 (via PDZ 1 and 2 domains).
    Miscellaneous:
    • Intragenic, in the second intron of RAB54B gene.

    Alternative splice isoforms for FSBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSBP Gene

Post-translational modifications for FSBP Gene

  • Ubiquitination at Lys15
  • Modification sites at PhosphoSitePlus

Other Protein References for FSBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSBP Gene

Domains & Families for FSBP Gene

Protein Domains for FSBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FSBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FSBP Gene

Function for FSBP Gene

Molecular function for FSBP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

Gene Ontology (GO) - Molecular Function for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20531236
GO:0005524 ATP binding IEA --
GO:0042802 identical protein binding IPI 19060904
genes like me logo Genes that share ontologies with FSBP: view

Animal Model Products

CRISPR Products

miRNA for FSBP Gene

miRTarBase miRNAs that target FSBP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSBP Gene

Localization for FSBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSBP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSBP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20531236
genes like me logo Genes that share ontologies with FSBP: view

Pathways & Interactions for FSBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FSBP: view

No data available for Pathways by source and SIGNOR curated interactions for FSBP Gene

Transcripts for FSBP Gene

mRNA/cDNA for FSBP Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSBP Gene

Fibrinogen silencer binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSBP Gene

No ASD Table

Relevant External Links for FSBP Gene

GeneLoc Exon Structure for
FSBP
ECgene alternative splicing isoforms for
FSBP

Expression for FSBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSBP Gene

Protein differential expression in normal tissues from HIPED for FSBP Gene

This gene is overexpressed in CD8 Tcells (41.9) and Retina (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FSBP Gene



Protein tissue co-expression partners for FSBP Gene

NURSA nuclear receptor signaling pathways regulating expression of FSBP Gene:

FSBP

SOURCE GeneReport for Unigene cluster for FSBP Gene:

Hs.30561

mRNA Expression by UniProt/SwissProt for FSBP Gene:

O95073-FSBP_HUMAN
Tissue specificity: Expressed in multiple tissues including brain.
genes like me logo Genes that share expression patterns with FSBP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSBP Gene

Orthologs for FSBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSBP 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia FSBP 34
  • 96.32 (n)
cow
(Bos Taurus)
Mammalia FSBP 34 35
  • 94.98 (n)
mouse
(Mus musculus)
Mammalia Fsbp 34 16 35
  • 89.07 (n)
rat
(Rattus norvegicus)
Mammalia LOC102550523 34
  • 88.26 (n)
oppossum
(Monodelphis domestica)
Mammalia FSBP 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves FSBP 34 35
  • 77.14 (n)
lizard
(Anolis carolinensis)
Reptilia FSBP 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fsbp 34
  • 63.97 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884826 34
  • 59.67 (n)
Species where no ortholog for FSBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSBP Gene

ENSEMBL:
Gene Tree for FSBP (if available)
TreeFam:
Gene Tree for FSBP (if available)

Paralogs for FSBP Gene

Paralogs for FSBP Gene

genes like me logo Genes that share paralogs with FSBP: view

Variants for FSBP Gene

Sequence variations from dbSNP and Humsavar for FSBP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000210868 -- 94,430,080(+) AGGCC(A/G)AGGCG intron-variant, utr-variant-3-prime
rs1000381786 -- 94,432,931(+) AGAAA(A/G)TAAAA intron-variant
rs1000773869 -- 94,438,943(+) AAAAA(A/T)TAGCC intron-variant, upstream-variant-2KB
rs1001115919 -- 94,431,504(+) GGGAT(A/G)GAAAT intron-variant, utr-variant-3-prime
rs1001218143 -- 94,429,323(+) GTATA(C/T)ACATA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FSBP Gene

Variant ID Type Subtype PubMed ID
nsv1031480 CNV gain 25217958
nsv611749 CNV loss 21841781
nsv6313 CNV insertion 18451855

Variation tolerance for FSBP Gene

Gene Damage Index Score: 1.06; 21.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSBP Gene

Disorders for FSBP Gene

Relevant External Links for FSBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FSBP

No disorders were found for FSBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSBP Gene

Publications for FSBP Gene

  1. An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. (PMID: 20531236) Lau K.F. … Miller C.C. (NeuroReport 2010) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3 64

Products for FSBP Gene

Sources for FSBP Gene

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