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Aliases for FSBP Gene

Aliases for FSBP Gene

  • Fibrinogen Silencer Binding Protein 2 3 5

External Ids for FSBP Gene

Previous GeneCards Identifiers for FSBP Gene

  • GC08U990078
  • GC08M095231
  • GC08M095112
  • GC08M095341
  • GC08M095400
  • GC08M095513

Summaries for FSBP Gene

GeneCards Summary for FSBP Gene

FSBP (Fibrinogen Silencer Binding Protein) is a Protein Coding gene. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for FSBP Gene

  • Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSBP Gene

Genomics for FSBP Gene

Regulatory Elements for FSBP Gene

Enhancers for FSBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F094434 1.3 Ensembl ENCODE 6.5 -1.1 -1088 7.9 PKNOX1 MLX WRNIP1 SIN3A ARID4B DMAP1 YY1 ZNF766 GATA2 ZNF143 RAD54B FSBP KIAA1429 ENSG00000253704 GC08M094432
GH08F093900 1.1 Ensembl ENCODE 5.9 +533.1 533085 6.7 PKNOX1 TBL1XR1 JUN ZNF175 CEBPG ZNF766 CBX5 PRDM10 NR2F6 FOS PDP1 LINC00535 FAM92A FSBP LOC105375646 GC08M093861
GH08F093696 0.6 ENCODE 10.4 +740.1 740115 0.8 PKNOX1 ZFP64 ZNF140 ZBTB8A ZNF623 ZNF518A ZNF781 PRDM12 ZNF433 RBM12B ENSG00000271971 KIAA1429 FAM92A LOC105375645 ENSG00000253722 FSBP ENSG00000253854 PIR47593
GH08F094058 1.1 Ensembl ENCODE 5 +377.3 377334 1.7 PKNOX1 ATF1 RAD21 YY1 RFX5 RCOR1 FOS CEBPB ZHX2 ZEB2 ENSG00000253585 FSBP GC08M094039
GH08F094467 0.7 Ensembl ENCODE 5.9 -31.2 -31235 1.5 JUND ZBTB33 MAFK KIAA1429 FSBP RAD54B GC08P094456
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FSBP on UCSC Golden Path with GeneCards custom track

Promoters for FSBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FSBP Gene

94,378,377 bp from pter
94,436,952 bp from pter
58,576 bases
Minus strand

Genomic View for FSBP Gene

Genes around FSBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSBP Gene

Proteins for FSBP Gene

  • Protein details for FSBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrinogen silencer-binding protein
    Protein Accession:
    Secondary Accessions:
    • Q8N4S5

    Protein attributes for FSBP Gene

    299 amino acids
    Molecular mass:
    34768 Da
    Quaternary structure:
    • Interacts with APBA1 (via PDZ 1 and 2 domains).
    • Intragenic, in the second intron of RAB54B gene.

    Alternative splice isoforms for FSBP Gene


neXtProt entry for FSBP Gene

Post-translational modifications for FSBP Gene

  • Ubiquitination at Lys 15
  • Modification sites at PhosphoSitePlus

Other Protein References for FSBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSBP Gene

Domains & Families for FSBP Gene

Protein Domains for FSBP Gene


Suggested Antigen Peptide Sequences for FSBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FSBP Gene

Function for FSBP Gene

Molecular function for FSBP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

Gene Ontology (GO) - Molecular Function for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20531236
GO:0042802 identical protein binding IPI 19060904
genes like me logo Genes that share ontologies with FSBP: view

Animal Model Products

miRNA for FSBP Gene

miRTarBase miRNAs that target FSBP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSBP Gene

Localization for FSBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSBP Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSBP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20531236
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FSBP: view

Pathways & Interactions for FSBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FSBP: view

No data available for Pathways by source and SIGNOR curated interactions for FSBP Gene

Transcripts for FSBP Gene

mRNA/cDNA for FSBP Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSBP Gene

Fibrinogen silencer binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSBP Gene

No ASD Table

Relevant External Links for FSBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FSBP Gene

Protein differential expression in normal tissues from HIPED for FSBP Gene

This gene is overexpressed in CD8 Tcells (41.9) and Retina (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSBP Gene

Protein tissue co-expression partners for FSBP Gene

NURSA nuclear receptor signaling pathways regulating expression of FSBP Gene:


SOURCE GeneReport for Unigene cluster for FSBP Gene:


mRNA Expression by UniProt/SwissProt for FSBP Gene:

Tissue specificity: Expressed in multiple tissues including brain.
genes like me logo Genes that share expression patterns with FSBP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FSBP Gene

Orthologs for FSBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FSBP 34
  • 99.67 (n)
(Canis familiaris)
Mammalia FSBP 34
  • 96.32 (n)
(Bos Taurus)
Mammalia FSBP 34 35
  • 94.98 (n)
(Mus musculus)
Mammalia Fsbp 34 16 35
  • 89.07 (n)
(Rattus norvegicus)
Mammalia LOC102550523 34
  • 88.26 (n)
(Monodelphis domestica)
Mammalia FSBP 35
  • 84 (a)
(Gallus gallus)
Aves FSBP 34 35
  • 77.14 (n)
(Anolis carolinensis)
Reptilia FSBP 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fsbp 34
  • 63.97 (n)
(Danio rerio)
Actinopterygii LOC101884826 34
  • 59.67 (n)
Species where no ortholog for FSBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSBP Gene

Gene Tree for FSBP (if available)
Gene Tree for FSBP (if available)

Paralogs for FSBP Gene

No data available for Paralogs for FSBP Gene

Variants for FSBP Gene

Sequence variations from dbSNP and Humsavar for FSBP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs111410396 -- 94,437,206(+) CTAAT(C/T)TAGTG intron-variant, upstream-variant-2KB
rs112041923 -- 94,429,736(+) AGTTA(C/T)ATATT intron-variant, utr-variant-3-prime
rs112217006 -- 94,428,779(+) CTTAA(C/T)GAAAC intron-variant, utr-variant-3-prime
rs113894493 -- 94,438,055(+) TTTTT(A/G)ATTAC intron-variant, upstream-variant-2KB
rs114902318 -- 94,427,788(+) TATAT(A/G)TTAAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FSBP Gene

Variant ID Type Subtype PubMed ID
nsv6313 CNV insertion 18451855
nsv611749 CNV loss 21841781
nsv1031480 CNV gain 25217958

Variation tolerance for FSBP Gene

Gene Damage Index Score: 1.06; 21.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSBP Gene

Disorders for FSBP Gene

Relevant External Links for FSBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FSBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSBP Gene

Publications for FSBP Gene

  1. An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. (PMID: 20531236) Lau K.F. … Miller C.C. (NeuroReport 2010) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3 64

Products for FSBP Gene

Sources for FSBP Gene

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