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Aliases for FSBP Gene

Aliases for FSBP Gene

  • Fibrinogen Silencer Binding Protein 2 3 5

External Ids for FSBP Gene

Previous GeneCards Identifiers for FSBP Gene

  • GC08U990078
  • GC08M095231
  • GC08M095112
  • GC08M095341
  • GC08M095400
  • GC08M095513

Summaries for FSBP Gene

GeneCards Summary for FSBP Gene

FSBP (Fibrinogen Silencer Binding Protein) is a Protein Coding gene. Among its related pathways are Homologous recombination. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for FSBP Gene

  • Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSBP Gene

Genomics for FSBP Gene

Regulatory Elements for FSBP Gene

Enhancers for FSBP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FSBP on UCSC Golden Path with GeneCards custom track

Promoters for FSBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FSBP on UCSC Golden Path with GeneCards custom track

Genomic Location for FSBP Gene

94,378,377 bp from pter
94,436,952 bp from pter
58,576 bases
Minus strand

Genomic View for FSBP Gene

Genes around FSBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSBP Gene

Proteins for FSBP Gene

  • Protein details for FSBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrinogen silencer-binding protein
    Protein Accession:
    Secondary Accessions:
    • Q8N4S5

    Protein attributes for FSBP Gene

    299 amino acids
    Molecular mass:
    34768 Da
    Quaternary structure:
    • Interacts with APBA1 (via PDZ 1 and 2 domains).
    • Intragenic, in the second intron of RAB54B gene.

    Alternative splice isoforms for FSBP Gene


neXtProt entry for FSBP Gene

Proteomics data for FSBP Gene at MOPED

Post-translational modifications for FSBP Gene

  • Ubiquitination at Lys 15
  • Modification sites at PhosphoSitePlus

Other Protein References for FSBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSBP Gene

Domains & Families for FSBP Gene

Protein Domains for FSBP Gene


Suggested Antigen Peptide Sequences for FSBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FSBP Gene

Function for FSBP Gene

Molecular function for FSBP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

Animal Model Products

CRISPR Products

miRNA for FSBP Gene

miRTarBase miRNAs that target FSBP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSBP Gene

Localization for FSBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSBP Gene

Subcellular locations from

Jensen Localization Image for FSBP Gene COMPARTMENTS Subcellular localization image for FSBP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FSBP: view

Pathways & Interactions for FSBP Gene

SuperPathways for FSBP Gene

Superpath Contained pathways
1 Homologous recombination
genes like me logo Genes that share pathways with FSBP: view

Pathways by source for FSBP Gene

1 BioSystems pathway for FSBP Gene

Gene Ontology (GO) - Biological Process for FSBP Gene


No data available for SIGNOR curated interactions for FSBP Gene

Drugs & Compounds for FSBP Gene

No Compound Related Data Available

Transcripts for FSBP Gene

mRNA/cDNA for FSBP Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSBP Gene

Fibrinogen silencer binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSBP Gene

No ASD Table

Relevant External Links for FSBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSBP Gene

mRNA expression in normal human tissues for FSBP Gene

Protein differential expression in normal tissues from HIPED for FSBP Gene

This gene is overexpressed in CD8 Tcells (41.9) and Retina (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSBP Gene

SOURCE GeneReport for Unigene cluster for FSBP Gene Hs.30561

mRNA Expression by UniProt/SwissProt for FSBP Gene

Tissue specificity: Expressed in multiple tissues including brain.
genes like me logo Genes that share expression patterns with FSBP: view

Protein tissue co-expression partners for FSBP Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FSBP Gene

Orthologs for FSBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSBP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FSBP 35
  • 94.98 (n)
  • 97.66 (a)
  • 98 (a)
(Canis familiaris)
Mammalia FSBP 35
  • 96.32 (n)
  • 97.32 (a)
(Mus musculus)
Mammalia Fsbp 35
  • 89.07 (n)
  • 87.96 (a)
Fsbp 16
Fsbp 36
  • 88 (a)
(Pan troglodytes)
Mammalia FSBP 35
  • 99.67 (n)
  • 99.67 (a)
(Rattus norvegicus)
Mammalia LOC102550523 35
  • 88.26 (n)
  • 86.24 (a)
(Monodelphis domestica)
Mammalia FSBP 36
  • 84 (a)
(Gallus gallus)
Aves FSBP 35
  • 77.14 (n)
  • 78.38 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia FSBP 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fsbp 35
  • 63.97 (n)
  • 57.91 (a)
(Danio rerio)
Actinopterygii LOC101884826 35
  • 59.67 (n)
  • 56.23 (a)
Species with no ortholog for FSBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSBP Gene

Gene Tree for FSBP (if available)
Gene Tree for FSBP (if available)

Paralogs for FSBP Gene

No data available for Paralogs for FSBP Gene

Variants for FSBP Gene

Sequence variations from dbSNP and Humsavar for FSBP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_019301 -

Variation tolerance for FSBP Gene

Gene Damage Index Score: 1.06; 21.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FSBP Gene

Disorders for FSBP Gene

Relevant External Links for FSBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FSBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSBP Gene

Publications for FSBP Gene

  1. An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. (PMID: 20531236) Lau K.F. … Miller C.C. (NeuroReport 2010) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for FSBP Gene

Sources for FSBP Gene