Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FRZB Gene

protein-coding   GIFtS: 59
GCID: GC02M183662

Frizzled-Related Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Frizzled-Related Protein1 2     FRZB-PEN2
FRZB12 3 5     FZRB2
Frizzled-Related Protein 12 3     frezzled2
FRE2 3     Frizzled Homolog-Related2
SFRP32 3     hFIZ2
sFRP-32 3     Secreted Frizzled-Related Protein 32
OS12 5     FIZ3
SRFP32 5     FRP3
FRITZ2     Frezzled3
FRP-32     Fritz3
FRZB-12     FrzB-13

External Ids:    HGNC: 39591   Entrez Gene: 24872   Ensembl: ENSG000001629987   OMIM: 6050835   UniProtKB: Q927653   

Export aliases for FRZB gene to outside databases

Previous GC identifers: GC02M181906 GC02M182382 GC02M183901 GC02M183524 GC02M183406 GC02M175555


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FRZB Gene:
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development.
Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. (provided by RefSeq, Apr
2010)

GeneCards Summary for FRZB Gene: 
FRZB (frizzled-related protein) is a protein-coding gene. Diseases associated with FRZB include osteoarthritis, and limb-girdle muscular dystrophy, and among its related super-pathways are Non-Canonical Wnt Pathway. GO annotations related to this gene include Wnt-activated receptor activity and PDZ domain binding. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte
maturation and long bone development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FRZB gene promoter:
         c-Fos   AML1a   AP-1   ATF-2   LCR-F1   N-Myc   IRF-7A   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRZB promoter sequence
   Search SABiosciences Chromatin IP Primers for FRZB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRZB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32.1

FRZB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRZB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M183662:  view genomic region     (about GC identifiers)

Start:
183,698,002 bp from pter      End:
183,731,890 bp from pter
Size:
33,889 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 3 precursor  
Size: 325 amino acids; 36254 Da
Subcellular location: Secreted (Probable)
Secondary accessions: O00181 Q99686

Explore the universe of human proteins at neXtProt for FRZB: NX_Q92765

Explore proteomics data for FRZB at MOPED 

FRZB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FRZB Protein Expression

REFSEQ proteins: NP_001454.2  
ENSEMBL proteins: 
 ENSP00000295113  

Human Recombinant Protein Products for FRZB: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for FRZB (sFRP-3)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for FRZB
OriGene Custom MassSpec 
OriGene Custom Protein Services for FRZB
GenScript Custom Purified and Recombinant Proteins Services for FRZB
Novus Biologicals FRZB Protein
Novus Biologicals FRZB Lysates
Sino Biological Recombinant Protein for FRZB
Sino Biological Cell Lysate for FRZB 
ProSpec Recombinant Protein for FRZB
Cloud-Clone Corp. Proteins for FRZB 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space ISS--
GO:0005737cytoplasm IBA--
GO:0016020membrane TAS8824257
GO:0032589NOT neuron projection membrane IKR--

FRZB for ontologies           About GeneDecksing



FRZB Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for FRZB (sFRP-3)
Browse OriGene Antibodies
OriGene Custom Antibody Services for FRZB
GenScript Custom Superior Antibodies Services for FRZB
Novus Biologicals FRZB Antibodies
Abcam antibodies for FRZB
Cloud-Clone Corp. Antibodies for FRZB 
Search ThermoFisher Antibodies for FRZB
LSBio Antibodies in human, mouse, rat for FRZB 

Assay Products for FRZB: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for FRZB
R&D Systems ELISAs for FRZB (sFRP-3)
GenScript Custom Assay Services for FRZB
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for FRZB 
Cloud-Clone Corp. CLIAs for FRZB


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SFRP: Secreted frizzled-related proteins

5/6 InterPro protein domains (see all 6):
 IPR008993 TIMP-like_OB-fold
 IPR020067 Frizzled_dom
 IPR026556 SFRP3
 IPR015526 Frizzled/SFRP
 IPR001134 Netrin_domain

Graphical View of Domain Structure for InterPro Entry Q92765

ProtoNet protein and cluster: Q92765

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
Similarity: Contains 1 FZ (frizzled) domain
Similarity: Contains 1 NTR domain


FRZB for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SFRP3_HUMAN, Q92765
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte
maturation and long bone development

     Genatlas biochemistry entry for FRZB:
Drosophila frizzled polarity homolog,secreted related protein 3,mouse sfrp 3 homolog,likely involved in WNT
binding and signal transduction

     Summary:
During embryonic development, FRZB as signaling molecule is secreted from the following cells: Cranial Neural Crest Cells in Branchial Arch 1 It affects the following cells: Muscle Progenitor Cells in Mandibular Arch Muscles

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0017147Wnt-protein binding ISS--
GO:0030165PDZ domain binding IBA--
GO:0042813Wnt-activated receptor activity IBA--
     
FRZB for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Frzb):
 behavior/neurological  hematopoietic system  homeostasis/metabolism  integument  limbs/digits/tail 
 nervous system  normal  skeleton 

FRZB for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for FRZB: Frzbtm1.1Fplu Frzbtm1Nat

   inGenious Targeting Laboratory - Custom generated mouse model solutions for FRZB 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FRZB

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FRZB 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FRZB 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRZB
8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate FRZB (see all 26):
hsa-miR-30c hsa-miR-449c* hsa-miR-106a hsa-miR-30d hsa-miR-301a hsa-miR-30a hsa-miR-93 hsa-miR-3150b-3p
SwitchGear 3'UTR luciferase reporter plasmidFRZB 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for FRZB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRZB

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for FRZB
Sirion Biotech Customized adenovirus for overexpression of FRZB

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for FRZB (see all 7)
OriGene ORF clones in mouse, rat for FRZB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FRZB (NM_001463)
Sino Biological Human cDNA Clone for FRZB
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRZB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRZB
Sirion Biotech Customized lentivirus for stable overexpression of FRZB 
                     Customized lentivirus expression plasmids for stable overexpression of FRZB 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for FRZB
LifeMap BioReagents: cell lines associated with FRZB: PureStem MEL2, NCr-fac Progenitor,
PureStem Progenitor E68
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRZB


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for FRZB About                                                                                                See pathways by source

SuperPathContained pathways About
1Canonical Wnt Pathway
Non-Canonical Wnt Pathway0.53
Canonical Wnt Pathway0.53
2WNT Signaling
WNT Signaling
3Adipogenesis
Adipogenesis
4Endochondral Ossification
Endochondral Ossification

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FRZB
    WNT Signaling

2 BioSystems Pathways for FRZB
    Adipogenesis
Endochondral Ossification

2 Sino Biological Pathways for FRZB 
    Canonical Wnt Pathway
Non-Canonical Wnt Pathway


Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FRZB

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/8 Interacting proteins for FRZB (Q927652, 3 ENSP000002951134) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
ELF5Q9UKW62, 3, ENSP000003110104MINT-8255470 I2D: score=2 STRING: ENSP00000311010
POLA2Q141812, 3, ENSP000002654654MINT-8255492 I2D: score=2 STRING: ENSP00000265465
RBX1P628772, 3, ENSP000002162254MINT-8255503 I2D: score=2 STRING: ENSP00000216225
BBS10Q8TAM12, 3MINT-8255448 I2D: score=2 
EHFQ9NZC42, 3, ENSP000002578314MINT-8255459 I2D: score=2 STRING: ENSP00000257831
About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001501skeletal system development TAS8824257
GO:0001944vasculature development IBA--
GO:0007409NOT axonogenesis IRD--
GO:0007420brain development IBA--
GO:0008285negative regulation of cell proliferation IDA--

FRZB for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FRZB (SFRP3)

Search CenterWatch for drugs/clinical trials and news about FRZB / SFRP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FRZB gene: 
NM_001463.3  

Unigene Cluster for FRZB:

Frizzled-related protein
Hs.128453  [show with all ESTs]
Unigene Representative Sequence: NM_001463
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000295113(uc002upa.2)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRZB
8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate FRZB (see all 26):
hsa-miR-30c hsa-miR-449c* hsa-miR-106a hsa-miR-30d hsa-miR-301a hsa-miR-30a hsa-miR-93 hsa-miR-3150b-3p
SwitchGear 3'UTR luciferase reporter plasmidFRZB 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for FRZB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRZB
Clone
Products:
     
OriGene clones in human, mouse for FRZB (see all 7)
OriGene ORF clones in mouse, rat for FRZB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FRZB (NM_001463)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRZB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRZB
Sirion Biotech Customized lentivirus for stable overexpression of FRZB 
                     Customized lentivirus expression plasmids for stable overexpression of FRZB 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FRZB
OriGene qSTAR qPCR primer pairs in human, mouse for FRZB
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRZB
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRZB
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRZB

Additional mRNA sequence: 

AK130009.1 AK312741.1 BC027855.1 BT019883.1 U24163.1 U68057.1 U91903.1 

9 DOTS entries:

DT.450737  DT.100817347  DT.95079727  DT.120999603  DT.202004  DT.86846649  DT.95148365  DT.216513 
DT.95148382 

24/270 AceView cDNA sequences (see all 270):

BU069075 BM662752 CR622855 BM702929 BC027855 BM691131 AI261406 AI878832 
BQ006836 BI964697 BI913244 BF174980 BM692935 CA393000 BM699964 AA442201 
BF725849 BM706252 CN479823 BM668253 AA058865 AW269316 AU141161 D79945 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FRZB expression in normal human tissues (normalized intensities)      FRZB embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGTTACCAG
FRZB Expression
About this image


FRZB expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/35 selected tissues (see all 35) fully expand
 
 Brain (Nervous System)    fully expand to see all 19 entries
         Postnatal Endothelial Cells Blood Brain Barrier
         Thalamus
         Septum   
 
 Bone (Muscoskeletal System)    fully expand to see all 9 entries
         Prechondrocytic Mesenchymal Cells Zeugopod
         Human fetal bone marrow-derived mesenchymal stromal cells
         HyStem+BMP4-induced MEL2 cells
         skeleton/pectoral girdle and thoracic body wall/sternum   
 
 Cartilage (Muscoskeletal System)    fully expand to see all 8 entries
         Prechondrocytic Mesenchymal Cells Zeugopod
         HyStem+BMP4-induced SM30 cells
         Normal Human Articular chondrocytes (NHAC)   
         fetal cartilage   
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 6 entries
         Cranial Neural Crest Cells Branchial Arch 1
         PureStem MEL2, NCr-fac Progenitor
         skeleton/cranium/chondrocranium   
 
 Neural Tube (Nervous System)    fully expand to see all 5 entries
         Telencephalon
         spinal cord/lateral wall/mantle layer   

See FRZB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FRZB

SOURCE GeneReport for Unigene cluster: Hs.128453

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
Tissue specificity: Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal
development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in
early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long
bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly
expressed in lung and liver

    SABiosciences Expression via Pathway-Focused PCR Arrays including FRZB: 
          Notch Signaling Targets in human mouse rat
          WNT Signaling Pathway in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for FRZB
OriGene qSTAR qPCR primer pairs in human, mouse for FRZB
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRZB
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRZB
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRZB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRZB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FRZB gene from 7/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Frzb1 , 5 frizzled-related protein1, 5 89.68(n)1
91.95(a)1
  2 (48.13 cM)5
203781  NM_011356.41  NP_035486.11 
 804119705 
chicken
(Gallus gallus)
Aves FRZB1 frizzled-related protein 81.43(n)
85.67(a)
  395545  NM_204772.2  NP_990103.1 
lizard
(Anolis carolinensis)
Reptilia FRZB6
Uncharacterized protein
76(a)
1 ↔ 1
GL343221.1(1992585-2038721)
African clawed frog
(Xenopus laevis)
Amphibia Frzb-12 Frzb-1 protein 76.15(n)    U68059.1 
zebrafish
(Danio rerio)
Actinopterygii frzb2 frizzled-related protein 77.76(n)   30119  AF116853.1 
fruit fly
(Drosophila melanogaster)
Insecta fz46
frizzled 4
9(a)
possible ortholog
X(7000305-7004325)
worm
(Caenorhabditis elegans)
Secernentea cfz-26
lin-176
(see all 3)
Protein LIN-17, isoform a
(see all 3)
12(a)
11(a)
(see all 3)
1 ↔ many
possible ortholog
(see all 3)
V(3441501-3444877)
I(2706883-2717549)


ENSEMBL Gene Tree for FRZB (if available)
TreeFam Gene Tree for FRZB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FRZB gene
FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
SMO2  FZD42  FZD62  SFRP12  SFRP52  FZD72  SFRP22  
4 SIMAP similar genes for FRZB using alignment to 4 protein entries:     SFRP3_HUMAN (see all proteins):
SFRP4    CORIN    FZD6    SFRP1

FRZB for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/745 SNPs in FRZB are shown (see all 745)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs77751,2,4
C,F,Hother1183087325(-) AAGCAC/GGCAAC 2 R G mis132Minor allele frequency- G:0.14MN NA NS EA WA CSA EU 9368
rs2883261,2,4
C,F,O,A,Hother1183091076(+) AGCCCG/AAATGA 2 /R /W mis1 ese3116Minor allele frequency- A:0.07NA EA NS MN PA EU CA WA 14950
rs1995752161,2
--175572257(+) TCAAG-/TTATAGG 1 -- int10--------
rs1478289071,2
C--175584846(+) TTTTC-/TTTTTTTT 1 -- int10--------
rs1814916101,2
--175585758(+) ATAAGA/TAAAAA 1 -- int10--------
rs1999938031,2
--175585762(+) AAAAA-/CAACCT 1 -- int10--------
rs1433466771,2
--183085325(+) GTTAGC/GTCTTC 1 -- ds50010--------
rs2883191,2
C,F,H--183085402(+) ctcccG/Aactcc 1 -- ds50015Minor allele frequency- A:0.01NS EA 924
rs1114156641,2
C,F--183085500(-) CGTAGG/ACGATA 1 -- ds50012Minor allele frequency- A:0.01NS WA 638
rs1120314461,2
C,F--183085652(-) TCATCT/CATCTA 1 -- ds50011Minor allele frequency- C:0.00NS 530

HapMap Linkage Disequilibrium report for FRZB (183698002 - 183731890 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for FRZB:    About this table     
Variant IDTypeSubtypePubMed ID
nsv875484CNV Loss21882294
esv34847CNV Gain17911159
nsv818096CNV Gain17921354
essv8969CNV CNV17122850
dgv1276e1CNV Complex17122850


Human Gene Mutation Database (HGMD): FRZB
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FRZB
DNA2.0 Custom Variant and Variant Library Synthesis for FRZB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605083   
OMIM disorders: 165720  
UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
  • Osteoarthritis 1 (OS1) [MIM:165720]: A degenerative disease of the joints characterized by degradation of
    the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include
    pain and joint stiffness often leading to significant disability and joint replacement. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 17 diseases for FRZB:    About MalaCards
    osteoarthritis    limb-girdle muscular dystrophy    retinal degeneration    fibrosarcoma
    muscular dystrophy    medulloblastoma    retinitis    renal cell carcinoma
    gastric cancer    myeloma    sarcoma    colorectal cancer
    arthritis    melanoma    prostate cancer    prostatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FRZB:
    Osteoarthritis

    FRZB for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for FRZB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis hip 67.8 2 16093844 (1), 17907185 (1)
    osteoarthritis 65.9 10 16889986 (2), 18819822 (1), 17237116 (1), 16093844 (1) (see all 8)
    retinal degeneration 38.5 1 12140190 (1)
    tumors 0 2 11468178 (1), 19067193 (1)
    cancer 0 1 19067193 (1)

    Genetic Association Database (GAD): FRZB
    Human Genome Epidemiology (HuGE) Navigator: FRZB (16 documents)

    Export disorders for FRZB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FRZB gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with FRZB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. (PubMed id 9118218)1, 2, 3, 9 Leyns L.... de Robertis E.M. (1997)
    2. Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. (PubMed id 8824257)1, 2, 3 Hoang B.... Luyten F.P. (1996)
    3. Fritz: a secreted frizzled-related protein that inhibits Wnt activity. (PubMed id 9178261)1, 2, 9 Mayr T.... Risau W. (1997)
    4. No association of the polymorphisms of the frizzled-r elated protein gene with peak bone mineral density in Chinese nuclear families. (PubMed id 20043861)1, 4, 9 Gao G....Yu J.B. (2010)
    5. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. (PubMed id 18406176)1, 4, 9 Kerkhof J.M....van Meurs J.B. (2008)
    6. Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia. (PubMed id 19067193)1, 4, 9 Berndt S.I....Hayes R.B. (2008)
    7. Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty. (PubMed id 17600823)1, 4, 9 Gordon A....Wilkinson J.M. (2007)
    8. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. (PubMed id 15818669)1, 4, 9 Min J.L....Slagboom P.E. (2005)
    9. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. (PubMed id 17237116)1, 4, 9 Rodriguez-Lopez J....Gonzalez A. (2007)
    10. The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk. (PubMed id 17420170)1, 4, 9 Shanmugam K.S....Burwinkel B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2487 HGNC: 3959 AceView: FRZB Ensembl:ENSG00000162998 euGenes: HUgn2487
    ECgene: FRZB H-InvDB: FRZB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FRZB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FRZB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FRZB gene:
    Search GeneIP for patents involving FRZB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FRZB (sFRP-3)   Browse Cell Culture Products  
     ELISAs for FRZB (sFRP-3)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for FRZB (sFRP-3)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FRZB  
     OriGene qPCR primer pairs and template standards for FRZB   OriGene Protein Over-expression Lysate for FRZB  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FRZB  
     OriGene qSTAR qPCR primer pairs in human, mouse for FRZB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FRZB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FRZB   OriGene Custom Protein Services for FRZB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FRZB
     QIAGEN SeqTarget long-range PCR primers for resequencing FRZB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRZB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRZB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRZB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRZB
     GenScript Custom Purified and Recombinant Proteins Services for FRZB GenScript cDNA clones with any tag delivered in your preferred vector for FRZB
     GenScript Custom Assay Services for FRZB GenScript Custom Superior Antibodies Services for FRZB
     GenScript Custom overexpressing Cell Line Services for FRZB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FRZB promoter
     Search Chromatin IP Primers for FRZB
     RT2 qPCR Primer Assay in human, mouse, rat FRZB
     GNC Network for FRZB
     SABiosciences PCR Arrays including human, mouse, rat FRZB
     Search Tocris compounds for FRZB (SFRP3)
     Proteins and Antibodies for FRZB
     Cell Lysates for FRZB
     cDNA Clones for FRZB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FRZB antibodies
     FRZB proteins
     FRZB lysates
     Antibodies for FRZB
     See all of Abcam's Antibodies, Kits and Proteins for FRZB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FRZB




     Proteins for FRZB
     Antibodies for FRZB
     ELISAs for FRZB
     CLIAs for FRZB
     Cell Lines associated with FRZB: PureStem MEL2, NCr-fac Progenitor,
    PureStem Progenitor E68
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRZB
     SwitchGear 3'UTR luciferase reporter plasmids for FRZB
     SwitchGear Promoter luciferase reporter plasmids for FRZB
     Search ThermoFisher Antibodies for FRZB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRZB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FRZB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FRZB
    Customized:
     lentivirus for stable overexpression of FRZB
     lentivirus expression plasmids for stable overexpression of FRZB
     adenovirus for overexpression of FRZB
     LSBio Antibodies in human, mouse, rat for FRZB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FRZB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4