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Aliases for FRZB Gene

Aliases for FRZB Gene

  • Frizzled-Related Protein 2 3
  • FRZB1 3 4 6
  • Frizzled-Related Protein 1 3 4
  • Frezzled 3 4
  • FRZB-1 3 4
  • SFRP-3 3 4
  • FRITZ 3 4
  • SRFP3 3 6
  • SFRP3 3 4
  • OS1 3 6
  • FRE 3 4
  • Secreted Frizzled-Related Protein 3 3
  • Frizzled Homolog-Related 3
  • FRZB-PEN 3
  • FRP-3 3
  • FZRB 3
  • HFIZ 3
  • FRP 4
  • FIZ 4

External Ids for FRZB Gene

Previous GeneCards Identifiers for FRZB Gene

  • GC02M181906
  • GC02M182382
  • GC02M183662
  • GC02M183901
  • GC02M183524
  • GC02M183406
  • GC02M175555

Summaries for FRZB Gene

Entrez Gene Summary for FRZB Gene

  • The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

GeneCards Summary for FRZB Gene

FRZB (Frizzled-Related Protein) is a Protein Coding gene. Diseases associated with FRZB include osteoarthritis. Among its related pathways are Endochondral Ossification and Adipogenesis. GO annotations related to this gene include PDZ domain binding and Wnt-activated receptor activity. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for FRZB Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRZB Gene

Genomics for FRZB Gene

Regulatory Elements for FRZB Gene

Genomic Location for FRZB Gene

182,833,275 bp from pter
182,867,162 bp from pter
33,888 bases
Minus strand

Genomic View for FRZB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRZB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRZB Gene

Proteins for FRZB Gene

  • Protein details for FRZB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secreted frizzled-related protein 3
    Protein Accession:
    Secondary Accessions:
    • O00181
    • Q99686

    Protein attributes for FRZB Gene

    325 amino acids
    Molecular mass:
    36254 Da
    Quaternary structure:
    • Interacts with MYOC.

neXtProt entry for FRZB Gene

Proteomics data for FRZB Gene at MOPED

Post-translational modifications for FRZB Gene

Other Protein References for FRZB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FRZB Gene

Domains for FRZB Gene

Gene Families for FRZB Gene

  • SFRP :Secreted frizzled-related proteins

Suggested Antigen Peptide Sequences for FRZB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92765
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
  • Contains 1 NTR domain.
  • Belongs to the secreted frizzled-related protein (sFRP) family.
genes like me logo Genes that share domains with FRZB: view

Function for FRZB Gene

Molecular function for FRZB Gene

GENATLAS Biochemistry: Drosophila frizzled polarity homolog,secreted related protein 3,mouse sfrp 3 homolog,likely involved in WNT binding and signal transduction
UniProtKB/Swiss-Prot Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development

LifeMap Function Summary for FRZB Gene

During embryonic development, FRZB as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for FRZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 NOT G-protein coupled receptor activity IBA --
GO:0005515 protein binding --
GO:0017147 Wnt-protein binding ISS --
GO:0030165 PDZ domain binding --
GO:0042813 NOT Wnt-activated receptor activity IBA --
genes like me logo Genes that share ontologies with FRZB: view
genes like me logo Genes that share phenotypes with FRZB: view

Animal Models for FRZB Gene

MGI Knock Outs for FRZB:

Animal Model Products

CRISPR Products

miRNA for FRZB Gene

miRTarBase miRNAs that target FRZB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FRZB Gene

Localization for FRZB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRZB Gene


Subcellular locations from

Jensen Localization Image for FRZB Gene COMPARTMENTS Subcellular localization image for FRZB gene
Compartment Confidence
extracellular 4
plasma membrane 3
endoplasmic reticulum 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FRZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS 22261194
GO:0005737 cytoplasm --
GO:0016020 membrane TAS 8824257
GO:0016021 NOT integral component of membrane IBA --
genes like me logo Genes that share ontologies with FRZB: view

Pathways for FRZB Gene

genes like me logo Genes that share pathways with FRZB: view

Pathways by source for FRZB Gene

2 Sino Biological pathways for FRZB Gene
1 Qiagen pathway for FRZB Gene
2 BioSystems pathways for FRZB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FRZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8824257
GO:0001944 vasculature development --
GO:0007420 brain development --
GO:0008285 negative regulation of cell proliferation IDA 20208569
GO:0008406 gonad development --
genes like me logo Genes that share ontologies with FRZB: view

Transcripts for FRZB Gene

mRNA/cDNA for FRZB Gene

(270) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRZB Gene

Frizzled-related protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRZB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRZB Gene

No ASD Table

Relevant External Links for FRZB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRZB Gene

mRNA expression in normal human tissues for FRZB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRZB Gene

This gene is overexpressed in Artery - Aorta (13.8), Artery - Tibial (6.4), and Artery - Coronary (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FRZB Gene

SOURCE GeneReport for Unigene cluster for FRZB Gene Hs.128453

mRNA Expression by UniProt/SwissProt for FRZB Gene

Tissue specificity: Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver
genes like me logo Genes that share expressions with FRZB: view

In Situ Assay Products

Orthologs for FRZB Gene

This gene was present in the common ancestor of animals.

Orthologs for FRZB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FRZB 35
  • 99.69 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia FRZB 35
  • 92.41 (n)
  • 96.31 (a)
  • 96 (a)
(Canis familiaris)
Mammalia FRZB 35
  • 88.34 (n)
  • 93.25 (a)
  • 93 (a)
(Mus musculus)
Mammalia Frzb 35
  • 89.06 (n)
  • 91.33 (a)
Frzb 16
Frzb 36
  • 92 (a)
(Monodelphis domestica)
Mammalia FRZB 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FRZB 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Frzb 35
  • 87.62 (n)
  • 90.71 (a)
(Gallus gallus)
Aves FRZB 35
  • 80.76 (n)
  • 84.9 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia FRZB 36
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Frzb-1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia frzb 35
  • 72.49 (n)
  • 79.11 (a)
Str.7018 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6378 35
(Danio rerio)
Actinopterygii frzb 35
  • 75.61 (n)
  • 77.78 (a)
frzb 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta fz4 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea cfz-2 36
  • 16 (a)
mom-5 36
  • 14 (a)
Species with no ortholog for FRZB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRZB Gene

Gene Tree for FRZB (if available)
Gene Tree for FRZB (if available)

Paralogs for FRZB Gene

Paralogs for FRZB Gene

Selected SIMAP similar genes for FRZB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FRZB: view

Variants for FRZB Gene

Sequence variations from dbSNP and Humsavar for FRZB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7775 other, - 182,834,857(-) AAGCA(C/G)GCAAC reference, missense
rs13009 -- 182,834,637(-) CTTAA(A/G)TATAT utr-variant-3-prime
rs21714 -- 182,845,409(+) CCAAC(C/T)TCCTA intron-variant
rs169641 -- 182,843,468(+) AATTA(C/T)CTTAA intron-variant
rs288244 -- 182,846,223(+) TGGAC(C/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRZB Gene

Variant ID Type Subtype PubMed ID
dgv1276e1 CNV Complex 17122850
essv8969 CNV CNV 17122850
esv34847 CNV Gain 17911159
nsv818096 CNV Gain 17921354
nsv875484 CNV Loss 21882294

Relevant External Links for FRZB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRZB Gene

Disorders for FRZB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FRZB Gene including...

Search for FRZB Gene in MalaCards »

(1) OMIM Diseases for FRZB Gene (605083)


  • Osteoarthritis 1 (OS1) [MIM:165720]: A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FRZB Gene

(5) Novoseek inferred disease relationships for FRZB Gene

Disease -log(P) Hits PubMed IDs
osteoarthritis hip 67.8 2
osteoarthritis 65.9 9
retinal degeneration 38.5 1
tumors 0 2
cancer 0 1

Relevant External Links for FRZB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FRZB: view

Publications for FRZB Gene

  1. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. (PMID: 9118218) Leyns L. … de Robertis E.M. (Cell 1997) 2 3 4 23
  2. Fritz: a secreted frizzled-related protein that inhibits Wnt activity. (PMID: 9178261) Mayr T. … Risau W. (Mech. Dev. 1997) 3 4 23
  3. Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. (PMID: 8824257) Hoang B. … Luyten F.P. (J. Biol. Chem. 1996) 2 3 4
  4. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. (PMID: 15818669) Min J.L. … Slagboom P.E. (Arthritis Rheum. 2005) 3 23 48
  5. No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families. (PMID: 20043861) Gao G. … Yu J.B. (BMC Med. Genet. 2010) 3 23 48

Products for FRZB Gene

Sources for FRZB Gene

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