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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FRZB Gene

protein-coding   GIFtS: 59
GCID: GC02M183662

frizzled-related protein
 Explore 22 diseases affiliated with
FRZB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FRZB    

Aliases
for FRZB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Frizzled-Related Protein1 2     Frizzled-Related Protein 12 3
FRZB11 2 3 5     SFRP-31
FRE1 2 3     OS12 5
SFRP31 2 3     Frezzled3
SRFP31 2 5     Frizzled Homolog-Related2
FRITZ1 2     Secreted Frizzled-Related Protein 32
FRP-31 2     FIZ3
FRZB-11 2     FRP3
FRZB-PEN1 2     Frezzled3
FZRB1 2     Fritz3
HFIZ1     FrzB-13

External Ids:    HGNC: 39591   Entrez Gene: 24872   Ensembl: ENSG000001629987   OMIM: 6050835   UniProtKB: Q927653   

Export aliases for FRZB gene to outside databases

Previous GC identifers: GC02M181906 GC02M182382 GC02M183901 GC02M183524 GC02M183406 GC02M175555


Summaries
for FRZB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FRZB:
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects
in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction
with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears
to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone
development




Genomic Views
for FRZB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FRZB gene promoter:
         c-Fos   AML1a   AP-1   ATF-2   LCR-F1   N-Myc   IRF-7A   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FRZB promoter sequence
   Search SABiosciences Chromatin IP Primers for FRZB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRZB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2qter   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2qter

FRZB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRZB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M183662:  view genomic region     (about GC identifiers)

Start:
 183,698,002 bp from pter      End:
 183,731,890 bp from pter
Size:
 33,889 bases      Orientation:
 minus strand

Proteins
for FRZB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 3 precursor  
Size: 325 amino acids; 36254 Da
Subcellular location: Secreted (Probable)
Secondary accessions: O00181 Q99686

Explore the universe of human proteins at neXtProt for FRZB: NX_Q92765

FRZB Protein expression data from MOPED and PaxDb:    About this image 
FRZB Protein Expression

REFSEQ proteins: NP_001454.2  
ENSEMBL proteins: 
 ENSP00000295113  

Human Recombinant Protein Products for FRZB: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for FRZB (sFRP-3)
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OriGene Protein Over-expression Lysate: FRZB
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Novus Biologicals FRZB Lysates
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for FRZB

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space ISS--
GO:0005737cytoplasm IBA--
GO:0016020membrane TAS8824257
GO:0032589NOT neuron projection membrane IKR--

FRZB for ontologies           About GeneDecksing



FRZB Antibody Products: 
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Uscn ELISAs and CLIAs for FRZB

Protein Domains /
Families
for FRZB gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
FRZB for domains           About GeneDecksing

5/6 InterPro domains/families (see all 6):
 IPR008993 TIMP-like_OB-fold
 IPR020067 Frizzled_dom
 IPR026556 SFRP3
 IPR015526 Frizzled/SFRP
 IPR001134 Netrin_domain

Graphical View of Domain Structure for InterPro Entry Q92765

ProtoNet protein and cluster: Q92765

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
Similarity: Contains 1 FZ (frizzled) domain
Similarity: Contains 1 NTR domain


Function
for FRZB gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Molecular Function:

     UniProtKB/Swiss-Prot Summary: SFRP3_HUMAN, Q92765
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction
with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears
to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone
development

     Genatlas biochemistry entry for FRZB:
Drosophila frizzled polarity homolog,secreted related protein 3,mouse sfrp 3 homolog,likely involved in WNT binding and
signal transduction

     Summary:  
During embryonic development, FRZB as signaling molecule is secreted from the following cells: Cranial Neural Crest Cells in Branchial Arch 1 It affects the following cells: Muscle Progenitor Cells in Mandibular Arch Muscles

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0017147Wnt-protein binding ISS--
GO:0030165PDZ domain binding IBA--
GO:0042813Wnt-activated receptor activity IBA--
     
FRZB for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Frzb):
 behavior/neurological  hematopoietic system  homeostasis/metabolism  integument  limbs/digits/tail 
 nervous system  normal  skeleton 

FRZB for phenotypes           About GeneDecksing

Animal Models:
     Mouse knock-outs for FRZB: Frzbtm1.1Fplu Frzbtm1Nat
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FRZB 

miRNA
Products:    		 OriGene 3'-UTR Clone: FRZB
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRZB
8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate FRZB (see all 26):
hsa-miR-30c hsa-miR-449c* hsa-miR-106a hsa-miR-30d hsa-miR-301a hsa-miR-30a hsa-miR-93 hsa-miR-3150b-3p
SwitchGear 3'UTR luciferase reporter plasmid: FRZB 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRZB (see all 7)
OriGene shRNA RFP: FRZB
OriGene siRNA: FRZB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRZB
Sirion Biotech Custom design and validation of potent shRNA sequences against FRZB 

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for FRZB
Sirion Biotech Customized adenovirus for overexpression of FRZB 
Sirion Biotech Customized adenovirus for potent knockdown of FRZB

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRZB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRZB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: FRZB (NM_001463)
Sino Biological Human cDNA Clone for FRZB
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRZB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRZB 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for FRZB
LifeMap BioReagents: cell lines associated with FRZB: PureStem MEL2, NCr-fac Progenitor,
PureStem Progenitor E68
Sirion Biotech Customized stable knockdown cell line services for FRZB 
Sirion Biotech Customized inducible knockdown cell line services for FRZB
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Sirion Biotech Customized inducible overexpressing cell line services for FRZB

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRZB


Pathways & Interactions
for FRZB gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1WNT Signaling
WNT Signaling1.00
2Adipogenesis
Adipogenesis1.00
3Endochondral Ossification
Endochondral Ossification1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FRZB
    WNT Signaling

2 BioSystems Pathways for FRZB 
    Adipogenesis
Endochondral Ossification


Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FRZB

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/8 Interacting proteins for FRZB (Q927652, 3 ENSP000002951134) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
ELF5Q9UKW62, 3, ENSP000003110104MINT-8255470 I2D: score=2 STRING: ENSP00000311010
POLA2Q141812, 3, ENSP000002654654MINT-8255492 I2D: score=2 STRING: ENSP00000265465
RBX1P628772, 3, ENSP000002162254MINT-8255503 I2D: score=2 STRING: ENSP00000216225
BBS10Q8TAM12, 3MINT-8255448 I2D: score=2 
EHFQ9NZC42, 3, ENSP000002578314MINT-8255459 I2D: score=2 STRING: ENSP00000257831
About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001501skeletal system development TAS8824257
GO:0001944vasculature development IBA--
GO:0007409NOT axonogenesis IRD--
GO:0007420brain development IBA--
GO:0008285negative regulation of cell proliferation IDA--

FRZB for ontologies           About GeneDecksing



Drugs & Compounds
for FRZB gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FRZB
Search CenterWatch for drugs/clinical trials and news about FRZB / SFRP3 

Transcripts
for FRZB gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for FRZB gene: 
NM_001463.3  

Unigene Cluster for FRZB:

Frizzled-related protein
Hs.128453  [show with all ESTs]
Unigene Representative Sequence: NM_001463
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000295113(uc002upa.2)

miRNA
Products:     		 OriGene 3'-UTR Clone: FRZB
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRZB
8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate FRZB (see all 26):
hsa-miR-30c hsa-miR-449c* hsa-miR-106a hsa-miR-30d hsa-miR-301a hsa-miR-30a hsa-miR-93 hsa-miR-3150b-3p
SwitchGear 3'UTR luciferase reporter plasmid: FRZB 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRZB (see all 7)
OriGene shRNA RFP: FRZB
OriGene siRNA: FRZB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRZB
Sirion Biotech Custom design and validation of potent shRNA sequences against FRZB 
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRZB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRZB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: FRZB (NM_001463)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRZB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRZB 
Primer
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Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRZB
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRZB
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRZB

Additional cDNA sequence: 

AK130009.1 AK312741.1 BC027855.1 BT019883.1 U24163.1 U68057.1 U91903.1 

9 DOTS entries:

DT.450737  DT.100817347  DT.95079727  DT.120999603  DT.202004  DT.86846649  DT.95148365  DT.216513 
DT.95148382 

24/270 AceView cDNA sequences (see all 270):

BI964697 NM_001463 BQ006836 BC027855 BQ024618 CN479823 AA648224 BM692935 
BF432553 BF058813 BM699964 CD105319 BI913244 CR593578 BM694265 BF174980 
BM691131 BQ182099 BQ022669 CA397610 AI423674 AU117730 BU733641 BM662752 

GeneLoc Exon Structure


Expression
for FRZB gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FRZB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTTACCAG
FRZB Expression
About this image

FRZB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18) 
Tissue Anatomical Compartment CellCategory (developmental path)
Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
AdiposeBody Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
AdiposeCranial Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
AdiposeFacial Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
AdiposeSubcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
EpiblastEpiblastEarly-Gastrula OrganizerEarly Embryo
Head MesenchymePrechordal MesenchymeMesencephalic Neural Crest CellsNeural Crest
Primitive StreakPrimitive NodePrimitive Node CellsEarly Embryo
Primitive StreakPrimitive StreakPrimitive Streak CellsEarly Embryo
BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10 LifeMap Cells 
NameCategory
PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
N2/LSB/S/F8-induced cells (Generation of midbra...)
Definitive endoderm-like cells (Generation and expan...)
Definitive endoderm-like cells (Generation of mesend...)
Posterior foregut-like cells (A scalable, suspensi...)
Definitive Endoderm (Generation of beta c...)
Embryoid bodies (Two-step protocol fo...)
HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)Bone, Cartilage
HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage

See FRZB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FRZB

SOURCE GeneReport for Unigene cluster: Hs.128453

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
Tissue specificity: Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal
development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early
chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly
expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and
liver

    SABiosciences Expression via Pathway-Focused PCR Arrays including FRZB: 
          Notch Signaling Targets in human mouse rat
          WNT Signaling Pathway in human mouse rat

Primer
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Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRZB
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRZB
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRZB
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRZB

Orthologs
for FRZB gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for FRZB gene from 4/16 species (see all 16)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves FRZB1 frizzled-related protein 81.43(n)
85.67(a)		   395545  NM_204772.2  NP_990103.1 
lizard
(Anolis carolinensis)		 Reptilia FRZB6
 --
 76(a)
 1 ↔ 1
 GL343221.1(1992585-2038721)
African clawed frog
(Xenopus laevis)		 Amphibia Frzb-12 Frzb-1 protein 76.15(n)    U68059.1 
zebrafish
(Danio rerio)		 Actinopterygii frzb2 frizzled-related protein 77.76(n)   30119  AF116853.1 


ENSEMBL Gene Tree for FRZB (if available)
TreeFam Gene Tree for FRZB (if available) 

Paralogs
for FRZB gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FRZB gene
FZD102  FZD32  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
SMO2  FZD42  FZD62  SFRP12  FZD72  SFRP52  SFRP22  
4 SIMAP similar genes for FRZB using alignment to 4 protein entries:     SFRP3_HUMAN (see all proteins):
SFRP4    CORIN    FZD6    SFRP1

FRZB for paralogs           About GeneDecksing



Genomic Variants
for FRZB gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/593 NCBI SNPs in FRZB are shown (see all 593)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 2 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs77751,2
C,F,Hother175556953(-) AAGCAC/GGCAAC 2 R G mis132Minor allele frequency- G:0.14MN NA NS EA WA CSA EU 9368
rs2883261,2
C,F,O,A,Hother175560704(+) AGCCCG/AAATGA 2 /R /W mis1 ese3116Minor allele frequency- A:0.07NA EA NS MN PA EU CA WA 14950
rs2883191,2
C,H--175555032(+) ctcccG/Aactcc 1 -- ds50015Minor allele frequency- A:0.01NS EA 924
rs1114156641,2
C,F--175555130(-) CGTAGG/ACGATA 1 -- ds50012Minor allele frequency- A:0.01NS WA 638
rs1120314461,2
C--175555282(-) TCATCT/CATCTA 1 -- ds50011Minor allele frequency- C:0.00NS 530
rs752211561,2
C,F--175555523(+) TGCTCC/TGCCAT 1 -- ut312Minor allele frequency- T:0.02NS WA 632
rs2883201,2
C,F,H--175555602(+) TTACAT/ACCTGA 1 -- ut3120Minor allele frequency- A:0.05EA NA MN NS WA 2496
rs168237971,2
C,F--175555968(+) CTGCAT/CATTTT 1 -- ut3111Minor allele frequency- C:0.10NA WA CSA NS EA 1039
rs168237991,2
C,F,H--175556060(+) TCCTGG/ATCAAT 1 -- ut3126Minor allele frequency- A:0.12NA NS EA WA CSA 2939
rs1134142221,2
C,F--175556066(-) TGCCGT/CATTGA 1 -- ut311Minor allele frequency- C:0.00NS 526

HapMap Linkage Disequilibrium report for FRZB (183698002 - 183731890 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for FRZB
     5 CNVs: 78893 8394 2417 9435 3401
Human Gene Mutation Database (HGMD): FRZB

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRZB
DNA2.0 Custom Variant and Variant Library Synthesis for FRZB

Disorders / Diseases
for FRZB gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
FRZB for disorders           About GeneDecksing

OMIM gene information: 605083   
OMIM disorders: 165720  
UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
  • Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1) [MIM:165720]. Osteoarthritis
    • is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling
    of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to
    significant disability and joint replacement

    20/22 diseases for FRZB (see all 22):    About MalaCards
    osteoarthritis    limb-girdle muscular dystrophy    muscular dystrophy    osteoarthritis susceptibility 1
    retinal degeneration    osteolysis    renal cell carcinoma    embryonal carcinoma
    retinitis    fibrosarcoma    osteoporosis    medulloblastoma
    gastric cancer    colorectal cancer    prostate cancer    myeloma
    sarcoma    carcinoma    prostatitis    arthritis

    1 disease from the University of Copenhagen DISEASES database for FRZB:
    Osteoarthritis

    5 Novoseek disease relationships for FRZB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis hip 67.8 2 16093844 (1), 17907185 (1)
    osteoarthritis 65.9 10 16889986 (2), 18819822 (1), 17237116 (1), 16093844 (1) (see all 8)
    retinal degeneration 38.5 1 12140190 (1)
    tumors 0 2 11468178 (1), 19067193 (1)
    cancer 0 1 19067193 (1)

    Genetic Association Database (GAD): FRZB
    Human Genome Epidemiology (HuGE) Navigator: FRZB (16 documents)

    Export disorders for FRZB gene to outside databases

    Publications
    for FRZB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FRZB gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with FRZB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. (PubMed id 9118218)1, 2, 3, 9 Leyns L.... de Robertis E.M. (1997)
    2. Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. (PubMed id 8824257)1, 2, 3 Hoang B.... Luyten F.P. (1996)
    3. Fritz: a secreted frizzled-related protein that inhibits Wnt activity. (PubMed id 9178261)1, 2, 9 Mayr T.... Risau W. (1997)
    4. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. (PubMed id 15818669)1, 4, 9 Min J.L....Slagboom P.E. (2005)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. (PubMed id 15210948)1, 2 Loughlin J.... Corr M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility. (PubMed id 16889986)1, 9 Snelling S....Loughlin J. (2007)
    9. Role of secreted frizzled-related protein 3 in human renal cell carcinoma. (PubMed id 20160027)1, 9 Hirata H....Dahiya R. (2010)
    10. No association of the polymorphisms of the frizzled-r elated protein gene with peak bone mineral density in Chinese nuclear families. (PubMed id 20043861)1, 9 Gao G....Yu J.B. (2010)

    External Searches for FRZB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FRZB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2487 HGNC: 3959 AceView: FRZB Ensembl:ENSG00000162998 euGenes: HUgn2487
    ECgene: FRZB H-InvDB: FRZB

    Other Databases showing FRZB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FRZB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FRZB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FRZB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FRZB gene:
    Search GeneIP for patents involving FRZB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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