Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FRZB Gene

protein-coding   GIFtS: 60
GCID: GC02M183662

Frizzled-Related Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Frizzled-Related Protein1 2     FRZB-PEN2
FRZB12 3 5     FZRB2
Frizzled-Related Protein 12 3     frezzled2
FRE2 3     Frizzled Homolog-Related2
SFRP32 3     hFIZ2
sFRP-32 3     Secreted Frizzled-Related Protein 32
OS12 5     FIZ3
SRFP32 5     FRP3
FRITZ2     Frezzled3
FRP-32     Fritz3
FRZB-12     FrzB-13

External Ids:    HGNC: 39591   Entrez Gene: 24872   Ensembl: ENSG000001629987   OMIM: 6050835   UniProtKB: Q927653   

Export aliases for FRZB gene to outside databases

Previous GC identifers: GC02M181906 GC02M182382 GC02M183901 GC02M183524 GC02M183406 GC02M175555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FRZB Gene:
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development.
Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. (provided by RefSeq, Apr
2010)

GeneCards Summary for FRZB Gene:
FRZB (frizzled-related protein) is a protein-coding gene. Diseases associated with FRZB include osteoarthritis, and limb-girdle muscular dystrophy. GO annotations related to this gene include Wnt-activated receptor activity and PDZ domain binding. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte
maturation and long bone development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRZB gene promoter:
         c-Fos   AML1a   AP-1   ATF-2   LCR-F1   N-Myc   IRF-7A   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRZB promoter sequence
   Search Chromatin IP Primers for FRZB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRZB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32.1

FRZB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRZB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M183662:  view genomic region     (about GC identifiers)

Start:
183,698,002 bp from pter      End:
183,731,890 bp from pter
Size:
33,889 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 3 precursor  
Size: 325 amino acids; 36254 Da
Secondary accessions: O00181 Q99686

Explore the universe of human proteins at neXtProt for FRZB: NX_Q92765

Explore proteomics data for FRZB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49

  • See FRZB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001454.2  
    ENSEMBL proteins: 
     ENSP00000295113  

    FRZB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FRZB (sFRP-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FRZB
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FRZB
    GenScript Custom Purified and Recombinant Proteins Services for FRZB
    Novus Biologicals FRZB Protein
    Novus Biologicals FRZB Lysates
    Sino Biological Recombinant Protein for FRZB
    Sino Biological Cell Lysate for FRZB
    ProSpec Recombinant Protein for FRZB
    Cloud-Clone Corp. Proteins for FRZB

    FRZB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FRZB (sFRP-3)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FRZB
    Novus Biologicals FRZB Antibodies
    Abcam antibodies for FRZB
    Cloud-Clone Corp. Antibodies for FRZB
    Search ThermoFisher Antibodies for FRZB
    LSBio Antibodies in human, mouse, rat for FRZB

    FRZB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FRZB
    R&D Systems ELISAs for FRZB (sFRP-3)
    GenScript Custom Assay Services for FRZB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FRZB
    Cloud-Clone Corp. CLIAs for FRZB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SFRP: Secreted frizzled-related proteins

    Selected InterPro protein domains (see all 6):
     IPR008993 TIMP-like_OB-fold
     IPR020067 Frizzled_dom
     IPR026556 SFRP3
     IPR015526 Frizzled/SFRP
     IPR001134 Netrin_domain

    Graphical View of Domain Structure for InterPro Entry Q92765

    ProtoNet protein and cluster: Q92765

    UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 NTR domain


    FRZB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFRP3_HUMAN, Q92765
    Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
    interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
    SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte
    maturation and long bone development

         Genatlas biochemistry entry for FRZB:
    Drosophila frizzled polarity homolog,secreted related protein 3,mouse sfrp 3 homolog,likely involved in WNT
    binding and signal transduction

         Summary: 
    During embryonic development, FRZB as signaling molecule is secreted from the following cells:
                
    Head Mesenchyme: Cranial Neural Crest Cells (Branchial Arch 1)

    It affects the following cells:
    Skeletal Muscle: Muscle Progenitor Cells (Mandibular Arch Muscles)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017147Wnt-protein binding ISS--
    GO:0030165PDZ domain binding IBA--
    GO:0042813Wnt-activated receptor activity IBA--
         
    FRZB for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Frzb):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  integument  limbs/digits/tail 
     nervous system  normal  skeleton 

    FRZB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FRZB: Frzbtm1.1Fplu Frzbtm1Nat

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FRZB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FRZB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FRZB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FRZB

    miRNA
    Products:
        
    miRTarBase miRNAs that target FRZB:
    hsa-mir-30b-5p (MIRT023431), hsa-mir-744-5p (MIRT037469)

    Block miRNA regulation of human, mouse, rat FRZB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRZB (see all 26):
    hsa-miR-30c hsa-miR-449c* hsa-miR-106a hsa-miR-30d hsa-miR-301a hsa-miR-30a hsa-miR-93 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFRZB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FRZB
    Predesigned siRNA for gene silencing in human, mouse, rat FRZB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FRZB

    Clone
    Products:
         
    OriGene clones in human, mouse for FRZB (see all 6)
    OriGene ORF clones in mouse, rat for FRZB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FRZB (NM_001463)
    Sino Biological Human cDNA Clone for FRZB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRZB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRZB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FRZB
    ESI BIO PureStem Progenitor for FRZB: 
    PureStem MEL2, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRZB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SFRP3_HUMAN, Q92765: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane3
    endoplasmic reticulum2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm IBA--
    GO:0016020membrane TAS8824257
    GO:0032589NOT neuron projection membrane IKR--

    FRZB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FRZB About    
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2WNT Signaling
    WNT Signaling
    3Endochondral Ossification
    Endochondral Ossification
    4Adipogenesis
    Adipogenesis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FRZB
        WNT Signaling

    2 BioSystems Pathways for FRZB
        Adipogenesis
    Endochondral Ossification

    2 Sino Biological Pathways for FRZB
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including FRZB: 
              Notch Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FRZB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for FRZB (Q927652, 3 ENSP000002951134) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELF5Q9UKW62, 3, ENSP000003110104MINT-8255470 I2D: score=2 STRING: ENSP00000311010
    POLA2Q141812, 3, ENSP000002654654MINT-8255492 I2D: score=2 STRING: ENSP00000265465
    RBX1P628772, 3, ENSP000002162254MINT-8255503 I2D: score=2 STRING: ENSP00000216225
    BBS10Q8TAM12, 3MINT-8255448 I2D: score=2 
    EHFQ9NZC42, 3, ENSP000002578314MINT-8255459 I2D: score=2 STRING: ENSP00000257831
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8824257
    GO:0001944vasculature development IBA--
    GO:0007409NOT axonogenesis IRD--
    GO:0007420brain development IBA--
    GO:0008285negative regulation of cell proliferation IDA--

    FRZB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FRZB (SFRP3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FRZB gene: 
    NM_001463.3  

    Unigene Cluster for FRZB:

    Frizzled-related protein
    Hs.128453  [show with all ESTs]
    Unigene Representative Sequence: NM_001463
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295113(uc002upa.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FRZB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRZB (see all 26):
    hsa-miR-30c hsa-miR-449c* hsa-miR-106a hsa-miR-30d hsa-miR-301a hsa-miR-30a hsa-miR-93 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFRZB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FRZB
    Predesigned siRNA for gene silencing in human, mouse, rat FRZB
    Clone
    Products:
         
    OriGene clones in human, mouse for FRZB (see all 6)
    OriGene ORF clones in mouse, rat for FRZB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FRZB (NM_001463)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRZB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRZB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FRZB
    OriGene qSTAR qPCR primer pairs in human, mouse for FRZB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRZB
      QuantiTect SYBR Green Assays in human, mouse, rat FRZB
      QuantiFast Probe-based Assays in human, mouse, rat FRZB

    Additional mRNA sequence: 

    AK130009.1 AK312741.1 BC027855.1 BT019883.1 U24163.1 U68057.1 U91903.1 

    9 DOTS entries:

    DT.450737  DT.100817347  DT.95079727  DT.120999603  DT.202004  DT.86846649  DT.95148365  DT.216513 
    DT.95148382 

    Selected AceView cDNA sequences (see all 270):

    BQ636871 BF058813 BM702929 BQ022669 BM692935 BF174980 AU141161 CA389038 
    BU737019 CD105319 AA058865 BQ021979 AU117730 AA648224 AI953962 CR620343 
    BU726213 BQ182099 BQ006836 AI423674 CR622855 BI832471 BI964697 AA059329 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FRZB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTACCAG
    FRZB Expression
    About this image


    FRZB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 4 entries
             Cranial Neural Crest Cells Branchial Arch 1
             PureStem MEL2, NCr-fac Progenitor
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 1
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Human fetal bone marrow-derived mesenchymal stromal cells
             HyStem+BMP4-induced MEL2 cells
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             Floor plate-like cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 5 entries
             Subcutaneous White Preadipocytes Facial Subcutaneous White Adipose
             HyStem+BMP4-induced SM30 cells
    FRZB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRZB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128453

    UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
    Tissue specificity: Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal
    development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in
    early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long
    bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly
    expressed in lung and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FRZB: 
              Notch Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FRZB
    OriGene qSTAR qPCR primer pairs in human, mouse for FRZB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRZB
    QuantiTect SYBR Green Assays in human, mouse, rat FRZB
    QuantiFast Probe-based Assays in human, mouse, rat FRZB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRZB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FRZB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frzb1 , 5 frizzled-related protein1, 5 89.06(n)1
    91.33(a)1
      2 (48.13 cM)5
    203781  NM_011356.41  NP_035486.11 
     804119705 
    chicken
    (Gallus gallus)
    Aves FRZB1 frizzled-related protein 80.76(n)
    84.9(a)
      395545  NM_204772.2  NP_990103.1 
    lizard
    (Anolis carolinensis)
    Reptilia FRZB6
    frizzled-related protein
    76(a)
    1 ↔ 1
    GL343221.1(1992585-2038721)
    African clawed frog
    (Xenopus laevis)
    Amphibia Frzb-12 Frzb-1 protein 76.15(n)    U68059.1 
    zebrafish
    (Danio rerio)
    Actinopterygii frzb2 frizzled-related protein 77.76(n)   30119  AF116853.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz46
    frizzled 4
    12(a)
    1 → many
    X(7000305-7004325)
    worm
    (Caenorhabditis elegans)
    Secernentea cfz-26
    mom-56
    Protein MOM-5 (mom-5) mRNA, complete cds
    16(a)
    14(a)
    many ↔ many
    many ↔ many
    V(3441501-3444877) WBGene00000478
    I(9965588-9969961) WBGene00003397


    ENSEMBL Gene Tree for FRZB (if available)
    TreeFam Gene Tree for FRZB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FRZB gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  FZD62  SFRP12  SFRP52  FZD72  SFRP22  
    4 SIMAP similar genes for FRZB using alignment to 4 protein entries:     SFRP3_HUMAN (see all proteins):
    SFRP4    CORIN    FZD6    SFRP1

    FRZB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FRZB (see all 745)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77751,2,,4
    C,F,Hother1183087325(-) AAGCAC/GGCAAC 2 R G mis132Minor allele frequency- G:0.14MN NA NS EA WA CSA EU 9368
    rs2883261,2,,4
    C,F,O,A,Hother1183091076(+) AGCCCG/AAATGA 2 /R /W mis1 ese3116Minor allele frequency- A:0.07NA EA NS MN PA EU CA WA 14950
    rs1995752161,2
    --175572257(+) TCAAG-/TTATAGG 1 -- int10--------
    rs1478289071,2
    C--175584846(+) TTTTC-/TTTTTTTT 1 -- int10--------
    rs1814916101,2
    --175585758(+) ATAAGA/TAAAAA 1 -- int10--------
    rs1999938031,2
    --175585762(+) AAAAA-/CAACCT 1 -- int10--------
    rs1433466771,2
    --183085325(+) GTTAGC/GTCTTC 1 -- ds50010--------
    rs2883191,2
    C,F,H--183085402(+) ctcccG/Aactcc 1 -- ds50015Minor allele frequency- A:0.01NS EA 924
    rs1114156641,2
    C,F--183085500(-) CGTAGG/ACGATA 1 -- ds50012Minor allele frequency- A:0.01NS WA 638
    rs1120314461,2
    C,F--183085652(-) TCATCT/CATCTA 1 -- ds50011Minor allele frequency- C:0.00NS 530

    HapMap Linkage Disequilibrium report for FRZB (183698002 - 183731890 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FRZB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875484CNV Loss21882294
    esv34847CNV Gain17911159
    nsv818096CNV Gain17921354
    essv8969CNV CNV17122850
    dgv1276e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FRZB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FRZB
    DNA2.0 Custom Variant and Variant Library Synthesis for FRZB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605083   
    OMIM disorders: 165720  
    UniProtKB/Swiss-Prot: SFRP3_HUMAN, Q92765
  • Osteoarthritis 1 (OS1) [MIM:165720]: A degenerative disease of the joints characterized by degradation of
    the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include
    pain and joint stiffness often leading to significant disability and joint replacement. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for FRZB (see all 22):    
    About MalaCards
    osteoarthritis    limb-girdle muscular dystrophy    retinal degeneration    osteoporosis
    fibrosarcoma    muscular dystrophy    medulloblastoma    retinitis
    labyrinthitis    renal cell carcinoma    myeloma    sarcoma
    arthritis    colorectal cancer    obesity    melanoma
    prostate cancer    prostatitis    multiple myeloma    cerebritis

    1 disease from the University of Copenhagen DISEASES database for FRZB:
    Osteoarthritis

    FRZB for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for FRZB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis hip 67.8 2 16093844 (1), 17907185 (1)
    osteoarthritis 65.9 10 16889986 (2), 18819822 (1), 17237116 (1), 16093844 (1) (see all 8)
    retinal degeneration 38.5 1 12140190 (1)
    tumors 0 2 11468178 (1), 19067193 (1)
    cancer 0 1 19067193 (1)

    Genetic Association Database (GAD): FRZB
    Human Genome Epidemiology (HuGE) Navigator: FRZB (16 documents)

    Export disorders for FRZB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FRZB gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with FRZB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. (PubMed id 9118218)1, 2, 3, 9 Leyns L.... de Robertis E.M. (Cell 1997)
    2. Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. (PubMed id 8824257)1, 2, 3 Hoang B.... Luyten F.P. (J. Biol. Chem. 1996)
    3. Fritz: a secreted frizzled-related protein that inhibits Wnt activity. (PubMed id 9178261)1, 2, 9 Mayr T.... Risau W. (Mech. Dev. 1997)
    4. No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families. (PubMed id 20043861)1, 4, 9 Gao G....Yu J.B. (BMC Med. Genet. 2010)
    5. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. (PubMed id 18406176)1, 4, 9 Kerkhof J.M....van Meurs J.B. (Osteoarthr. Cartil. 2008)
    6. Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia. (PubMed id 19067193)1, 4, 9 Berndt S.I....Hayes R.B. (amp 2009)
    7. Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty. (PubMed id 17600823)1, 4, 9 Gordon A....Wilkinson J.M. (J. Orthop. Res. 2007)
    8. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. (PubMed id 15818669)1, 4, 9 Min J.L....Slagboom P.E. (Arthritis Rheum. 2005)
    9. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. (PubMed id 17237116)1, 4, 9 Rodriguez-Lopez J....Gonzalez A. (Ann. Rheum. Dis. 2007)
    10. The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk. (PubMed id 17420170)1, 4, 9 Shanmugam K.S....Burwinkel B. (Carcinogenesis 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2487 HGNC: 3959 AceView: FRZB Ensembl:ENSG00000162998 euGenes: HUgn2487
    ECgene: FRZB H-InvDB: FRZB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FRZB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FRZB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FRZB gene:
    Search GeneIP for patents involving FRZB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for FRZB (sFRP-3)   Browse Cell Culture Products  
     ELISAs for FRZB (sFRP-3)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FRZB (sFRP-3)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FRZB  
     OriGene qPCR primer pairs and template standards for FRZB   OriGene Protein Over-expression Lysate for FRZB  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FRZB  
     OriGene qSTAR qPCR primer pairs in human, mouse for FRZB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FRZB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FRZB   OriGene Custom Protein Services for FRZB  

     
     
     Block miRNA regulation of human, mouse, rat FRZB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FRZB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRZB Predesigned siRNA for gene silencing in human, mouse, rat FRZB
     QuantiFast Probe-based Assays in human, mouse, rat FRZB QuantiTect SYBR Green Assays in human, mouse, rat FRZB
     PCR Arrays including human, mouse, rat FRZB Search Chromatin IP Primers for FRZB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRZB  GeneGlobe Interaction Network for FRZB
     Regulatory tfbs in FRZB promoter
     GenScript Custom Purified and Recombinant Proteins Services for FRZB GenScript cDNA clones with any tag delivered in your preferred vector for FRZB
     GenScript Custom Assay Services for FRZB GenScript Custom overexpressing Cell Line Services for FRZB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FRZB (SFRP3)
     Proteins for FRZB
     Cell Lysates for FRZB
     cDNA Clones for FRZB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FRZB antibodies
     FRZB proteins
     FRZB lysates
     Antibodies for FRZB
     See all of Abcam's Antibodies, Kits and Proteins for FRZB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FRZB
     Proteins for FRZB
     Antibodies for FRZB
     ELISAs for FRZB
     CLIAs for FRZB



     PureStem Progenitor for FRZB: PureStem MEL2, NCr-fac Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRZB
     SwitchGear 3'UTR luciferase reporter plasmids for FRZB
     SwitchGear Promoter luciferase reporter plasmids for FRZB
     Search ThermoFisher Antibodies for FRZB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRZB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FRZB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FRZB
     LSBio Antibodies in human, mouse, rat for FRZB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FRZB gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4