Aliases for FRZB Gene
External Ids for FRZB Gene
Previous GeneCards Identifiers for FRZB Gene
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
GeneCards Summary for FRZB Gene
FRZB (Frizzled-Related Protein) is a Protein Coding gene. Diseases associated with FRZB include Osteoarthritis 1 and Osteoarthritis. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Endochondral Ossification. GO annotations related to this gene include G-protein coupled receptor activity and Wnt-protein binding. An important paralog of this gene is SFRP4.
UniProtKB/Swiss-Prot for FRZB Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.