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Aliases for FRYL Gene

Aliases for FRYL Gene

  • FRY-Like 2 3
  • KIAA0826 2 3 4
  • ALL1-Fused Gene From Chromosome 4p12 Protein 3 4
  • Furry Homolog-Like (Drosophila) 2
  • Protein Furry Homolog-Like 3
  • Furry Homolog-Like 3
  • Furry-Like 3
  • AF4P12 4

External Ids for FRYL Gene

Previous HGNC Symbols for FRYL Gene

  • KIAA0826

Previous GeneCards Identifiers for FRYL Gene

  • GC04M048342
  • GC04M048194
  • GC04M047819

Summaries for FRYL Gene

GeneCards Summary for FRYL Gene

FRYL (FRY-Like) is a Protein Coding gene. An important paralog of this gene is FRY.

UniProtKB/Swiss-Prot for FRYL Gene

  • Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRYL Gene

Genomics for FRYL Gene

Regulatory Elements for FRYL Gene

Genomic Location for FRYL Gene

Start:
48,497,361 bp from pter
End:
48,780,322 bp from pter
Size:
282,962 bases
Orientation:
Minus strand

Genomic View for FRYL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRYL Gene

Proteins for FRYL Gene

  • Protein details for FRYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94915-FRYL_HUMAN
    Recommended name:
    Protein furry homolog-like
    Protein Accession:
    O94915
    Secondary Accessions:
    • O95640
    • Q8WTZ5
    • Q9NT40

    Protein attributes for FRYL Gene

    Size:
    3013 amino acids
    Molecular mass:
    339598 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRYL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRYL Gene

Proteomics data for FRYL Gene at MOPED

Post-translational modifications for FRYL Gene

  • Ubiquitination at Lys2232, Lys2240, and Lys2279
  • Modification sites at PhosphoSitePlus

Other Protein References for FRYL Gene

No data available for DME Specific Peptides for FRYL Gene

Domains for FRYL Gene

Protein Domains for FRYL Gene

Suggested Antigen Peptide Sequences for FRYL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94915

UniProtKB/Swiss-Prot:

FRYL_HUMAN :
  • O94915
Family:
  • Belongs to the furry protein family.
genes like me logo Genes that share domains with FRYL: view

No data available for Gene Families for FRYL Gene

Function for FRYL Gene

Molecular function for FRYL Gene

UniProtKB/Swiss-Prot Function: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.

Gene Ontology (GO) - Molecular Function for FRYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FRYL: view

Phenotypes for FRYL Gene

MGI mutant phenotypes for FRYL:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FRYL: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FRYL Gene

Localization for FRYL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRYL Gene COMPARTMENTS Subcellular localization image for FRYL gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FRYL Gene

Pathways for FRYL Gene

SuperPathways for FRYL Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FRYL: view

No data available for Pathways by source for FRYL Gene

Transcripts for FRYL Gene

mRNA/cDNA for FRYL Gene

(10) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRYL Gene

FRY-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRYL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: -
SP2:
SP3:
SP4: -
SP5:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
SP1: - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for FRYL Gene

GeneLoc Exon Structure for
FRYL
ECgene alternative splicing isoforms for
FRYL

Expression for FRYL Gene

mRNA expression in normal human tissues for FRYL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRYL Gene

SOURCE GeneReport for Unigene cluster for FRYL Gene Hs.595553

mRNA Expression by UniProt/SwissProt for FRYL Gene

O94915-FRYL_HUMAN
Tissue specificity: Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin.
genes like me logo Genes that share expressions with FRYL: view

No data available for mRNA differential expression in normal tissues for FRYL Gene

Orthologs for FRYL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FRYL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRYL 35
  • 99.76 (n)
  • 99.8 (a)
FRYL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRYL 35
  • 93.15 (n)
  • 97.34 (a)
FRYL 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRYL 35
  • 93.49 (n)
  • 97.01 (a)
FRYL 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fryl 35
  • 86.62 (n)
  • 94.71 (a)
Fryl 16
Fryl 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRYL 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRYL 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fryl 35
  • 86.36 (n)
  • 93.95 (a)
chicken
(Gallus gallus)
Aves FRYL 35
  • 84.54 (n)
  • 91.97 (a)
FRYL 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRYL 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fryl 35
  • 79.54 (n)
  • 88.85 (a)
zebrafish
(Danio rerio)
Actinopterygii fryl 35
  • 70.74 (n)
  • 81.3 (a)
fryl 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004892 35
  • 50.81 (n)
  • 45.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta fry 35
  • 52.41 (n)
  • 50.12 (a)
worm
(Caenorhabditis elegans)
Secernentea sax-2 35
  • 46.36 (n)
  • 35.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAO3 36
  • 20 (a)
OneToMany
Species with no ortholog for FRYL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRYL Gene

ENSEMBL:
Gene Tree for FRYL (if available)
TreeFam:
Gene Tree for FRYL (if available)

Paralogs for FRYL Gene

Paralogs for FRYL Gene

Selected SIMAP similar genes for FRYL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FRYL: view

Variants for FRYL Gene

Sequence variations from dbSNP and Humsavar for FRYL Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs707719 -- 48,633,500(+) GATCA(C/T)CAGTA intron-variant
rs707720 -- 48,668,948(-) AATAT(A/T)CTGTA intron-variant
rs776579 -- 48,623,196(+) AAAAA(A/C)AAACA intron-variant
rs776580 -- 48,653,618(+) CTTTT(A/T)ATCTA intron-variant
rs776581 -- 48,655,552(+) TATCC(C/T)CCAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FRYL Gene

Variant ID Type Subtype PubMed ID
nsv470034 CNV Gain 18288195
nsv829925 CNV Gain+Loss 17160897
esv2581662 CNV Deletion 19546169
nsv513131 CNV Loss 21212237
esv989650 CNV Deletion 20482838
esv2727542 CNV Deletion 23290073
dgv6e22 CNV Deletion 17803354
esv2676381 CNV Deletion 23128226
esv27329 CNV Loss 19812545
nsv822558 CNV Loss 20364138
esv33592 CNV Loss 17666407

Relevant External Links for FRYL Gene

HapMap Linkage Disequilibrium report
FRYL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRYL Gene

Disorders for FRYL Gene

UniProtKB/Swiss-Prot

FRYL_HUMAN
  • Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein.

No disorders were found for FRYL Gene.

Publications for FRYL Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner. (PMID: 16061630) Hayette S. … Rimokh R. (Cancer Res. 2005) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for FRYL Gene

Sources for FRYL Gene

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