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FRYL Gene

protein-coding   GIFtS: 49
GCID: GC04M048499

FRY-Like

(Previous names: KIAA0826, furry homolog-like (Drosophila))
(Previous symbol: KIAA0826)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
FRY-like1 2     Furry Homolog-Like2
KIAA08261 2 3     furry-like2
ALL1-Fused Gene From Chromosome 4p12 Protein2 3     Protein Furry Homolog-Like2
Furry Homolog-Like (Drosophila)1     AF4P123

External Ids:    HGNC: 291271   Entrez Gene: 2855272   Ensembl: ENSG000000755397   UniProtKB: O949153   
ORGUL members:         

Export aliases for FRYL gene to outside databases

Previous GC identifers: GC04M048342 GC04M048194 GC04M047819


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FRYL Gene:
FRYL (FRY-like) is a protein-coding gene. An important paralog of this gene is FRY.

UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915
Function: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis,
regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting
avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function
as a transcriptional activator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRYL gene promoter:
         CUTL1   HNF-3beta   E47   C/EBPalpha   GATA-2   AREB6   S8   FOXO4   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FRYL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRYL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p11   Ensembl cytogenetic band:  4p11   HGNC cytogenetic band: 4p12

FRYL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRYL gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M048499:  view genomic region     (about GC identifiers)

Start:
48,499,378 bp from pter      End:
48,782,339 bp from pter
Size:
282,962 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915 (See protein sequence)
Recommended Name: Protein furry homolog-like  
Size: 3013 amino acids; 339598 Da
Secondary accessions: O95640 Q8WTZ5 Q9NT40
Alternative splicing: 2 isoforms:  O94915-1   O94915-2   

Explore the universe of human proteins at neXtProt for FRYL: NX_O94915

Explore proteomics data for FRYL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys2232, Lys2240, Lys2279
  • Modification sites at PhosphoSitePlus

  • See FRYL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055845.1  
    ENSEMBL proteins: 
     ENSP00000426064   ENSP00000422408   ENSP00000425344   ENSP00000421584   ENSP00000425592  
     ENSP00000422988   ENSP00000351113   ENSP00000441114   ENSP00000264319  

    FRYL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FRYL

     
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    Search antibodies-online for peptides for FRYL

    FRYL Antibody Products:

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    antibodies-online antibodies for FRYL (2 products) 

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    antibodies-online kits for FRYL (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR025614 Cell_morpho_N
     IPR025481 Cell_Morphogen_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O94915

    ProtoNet protein and cluster: O94915

    UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915
    Similarity: Belongs to the furry protein family


    Find genes that share domains with FRYL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRYL_HUMAN, O94915
    Function: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis,
    regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting
    avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function
    as a transcriptional activator

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FRYL           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fryl):
     mortality/aging 

    Find genes that share phenotypes with FRYL           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FRYL

    miRNA
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    Block miRNA regulation of human, mouse, rat FRYL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRYL (see all 56):
    hsa-miR-607 hsa-miR-146a hsa-miR-15a hsa-miR-128 hsa-miR-25 hsa-miR-16-1* hsa-miR-624* hsa-miR-624
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRYL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FRYL
    Interactions:

        Search GeneGlobe Interaction Network for FRYL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FRYL (O949151, 2, 3 ENSP000003511134) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319461, 2, 3, ENSP000003001614EBI-1104821,EBI-359815 MINT-50946 I2D: score=3 STRING: ENSP00000300161
    BAK1Q166111, 3, ENSP000003635914EBI-1104821,EBI-519866 I2D: score=2 STRING: ENSP00000363591
    YWHAGP619811, 3, ENSP000003063304EBI-1104821,EBI-359832 I2D: score=2 STRING: ENSP00000306330
    STK38LQ9Y2H13, ENSP000003736844I2D: score=6 STRING: ENSP00000373684
    NUBP1P533843, ENSP000002830274I2D: score=4 STRING: ENSP00000283027
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with FRYL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FRYL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FRYL gene (2 alternative transcripts): 
    NM_001039751.1  NM_015030.1  

    Unigene Cluster for FRYL:

    FRY-like
    Hs.595553  [show with all ESTs]
    Unigene Representative Sequence: NM_015030
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000503238(uc003gyf.1 uc003gyi.1) ENST00000507873 ENST00000503339(uc003gye.1)
    ENST00000512810 ENST00000514617 ENST00000513401(uc003gyj.1) ENST00000512297
    ENST00000502925 ENST00000507711(uc003gyk.3) ENST00000511343 ENST00000506685
    ENST00000302806(uc003gyl.1) ENST00000505759 ENST00000505437 ENST00000502520
    ENST00000514783(uc003gyn.3) ENST00000509886 ENST00000515684
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FRYL (see all 56):
    hsa-miR-607 hsa-miR-146a hsa-miR-15a hsa-miR-128 hsa-miR-25 hsa-miR-16-1* hsa-miR-624* hsa-miR-624
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for FRYL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FRYL (NM_015030)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRYL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRYL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FRYL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRYL
      QuantiTect SYBR Green Assays in human, mouse, rat FRYL
      QuantiFast Probe-based Assays in human, mouse, rat FRYL

    Additional mRNA sequence: 

    AB020633.1 AK025034.1 AK127307.1 AK128452.1 AK131250.1 AL137546.1 AL833170.1 AL833444.1 
    BC021803.1 BC040987.2 BC050336.1 CR627228.1 DQ299937.1 DQ299938.1 DQ299939.1 DQ299940.1 
    U80082.1 

    22 DOTS entries:

    DT.92006270  DT.100777997  DT.95227718  DT.100777999  DT.121256117  DT.121256039  DT.440252  DT.91666820 
    DT.101964149  DT.445485  DT.95071262  DT.97784386  DT.121256066  DT.100740400  DT.100809875  DT.40111033 
    DT.95254737  DT.99958352  DT.40114782  DT.40122360  DT.91884207  DT.92057228 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FRYL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
    SP1:                                                  -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                            -                                                               
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
    SP1:  -                             -                                 
    SP2:                                                                  
    SP3:                                -                                 
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for FRYL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FRYL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGGAGTC
    FRYL Expression
    About this image


    FRYL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary Oocyte Antral Follicle
             Oviduct
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    FRYL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRYL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.595553

    UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915
    Tissue specificity: Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRYL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FRYL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fryl1 , 5 furry homolog-like (Drosophila)1, 5 86.62(n)1
    94.71(a)1
      5 (38.44 cM)5
    723131  NM_028194.21  NP_082470.21 
     730203225 
    chicken
    (Gallus gallus)
    Aves FRYL1 FRY-like 84.54(n)
    91.97(a)
      422765  XM_003641236.2  XP_003641284.2 
    lizard
    (Anolis carolinensis)
    Reptilia FRYL6
    FRY-like
    88(a)
    1 ↔ 1
    GL343293.1(890315-999187)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fryl1 FRY-like 79.54(n)
    88.85(a)
      779572  XM_004911205.1  XP_004911262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fryl1 furry homolog-like (Drosophila) 70.74(n)
    81.3(a)
      558173  NM_001159667.1  NP_001153139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fry1 furry 52.41(n)
    50.12(a)
      39122  NM_001274710.1  NP_001261639.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sax-21 sax-2 46.36(n)
    35.36(a)
      175697  NM_171117.4  NP_741131.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAO36
    Component of the RAM signaling network that is inv...
    20(a)
    1 → many
    IX(106107-113237) YIL129C


    ENSEMBL Gene Tree for FRYL (if available)
    TreeFam Gene Tree for FRYL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FRYL gene
    FRY2  
    5 SIMAP similar genes for FRYL using alignment to 6 protein entries:     FRYL_HUMAN (see all proteins):
    DKFZp781A0295    FRY    DKFZp686K08123    214K23.2    WUGSC

    Find genes that share paralogs with FRYL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FRYL (see all 4818)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826045091,2
    --48499033(+) TTTGCC/TACACC 1 -- ds50010--------
    rs1880239311,2
    --48499126(+) ACTGCC/TGGATT 1 -- ds50010--------
    rs1470233751,2
    --48499316(+) GAGAAA/GTGTAG 1 -- ds50010--------
    rs1385604261,2
    --48499413(+) TAATAA/GACTTA 1 -- ut310--------
    rs1441354651,2
    --48499554(+) AATCAC/TTCATT 1 -- ut310--------
    rs1433841461,2
    --48499633(+) GGGTAA/GGAAAA 1 -- ut310--------
    rs1483634831,2
    --48499907(+) GCATAC/TGTAAT 1 -- ut310--------
    rs1916636121,2
    --48499938(+) CACCCC/TCCAAG 1 -- ut310--------
    rs1161996361,2
    C,F--48500178(+) AGACAG/CTGAAT 1 -- ut311Minor allele frequency- C:0.03NA 120
    rs1826302711,2
    --48500397(+) TTCTTA/GTATAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FRYL (48499378 - 48749378 bp, first 250kb of FRYL)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FRYL (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676381CNV Deletion23128226
    dgv6e22CNV Deletion17803354
    esv2581662CNV Deletion19546169
    esv989650CNV Deletion20482838
    esv2727542CNV Deletion23290073
    esv33592CNV Loss17666407
    nsv513131CNV Loss21212237
    esv27329CNV Loss19812545
    nsv822558CNV Loss20364138
    nsv470034CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915
  • Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia
    (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein


  • Find genes that share disorders with FRYL           About GenesLikeMe


    Export disorders for FRYL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FRYL gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with FRYL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner. (PubMed id 16061630)1, 2 Hayette S.... Rimokh R. (Cancer Res. 2005)
    3. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    4. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    5. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    6. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (Mol. Cell 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285527 HGNC: 29127 Ensembl:ENSG00000075539 euGenes: HUgn285527 ECgene: FRYL
    H-InvDB: FRYL

    (According to HUGE)
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    HUGE: KIAA0826

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FRYL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FRYL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FRYL gene:
    Search GeneIP for patents involving FRYL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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