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Aliases for FRYL Gene

Aliases for FRYL Gene

  • FRY Like Transcription Coactivator 2 3 5
  • KIAA0826 2 3 4
  • ALL1-Fused Gene From Chromosome 4p12 Protein 3 4
  • AF4p12 3 4
  • Mor2 Cell Polarity Protein Homolog (S. Pombe) 2
  • Mor2 Cell Polarity Protein Homolog 3
  • Furry Homolog-Like (Drosophila) 2
  • Protein Furry Homolog-Like 3
  • Furry Homolog-Like 3
  • Furry-Like 3
  • FRY Like 2
  • FRY-Like 3
  • MOR2 3

External Ids for FRYL Gene

Previous HGNC Symbols for FRYL Gene

  • KIAA0826

Previous GeneCards Identifiers for FRYL Gene

  • GC04M048342
  • GC04M048194
  • GC04M047819

Summaries for FRYL Gene

GeneCards Summary for FRYL Gene

FRYL (FRY Like Transcription Coactivator) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is FRY.

UniProtKB/Swiss-Prot for FRYL Gene

  • Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRYL Gene

Genomics for FRYL Gene

Regulatory Elements for FRYL Gene

Enhancers for FRYL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G048968 0.9 ENCODE dbSUPER 10.9 -189.3 -189322 3.1 BHLHE40 CEBPB CEBPG DPF2 JUND ZNF316 ATF3 ZNF629 FOS NFE2 FRYL OCIAD2 OCIAD1-AS1 CWH43 GC04M048853
GH04G048600 0.7 ENCODE 12.7 +177.1 177131 4.6 SOX5 HNRNPUL1 SOX13 FOXA2 SAP130 FOXA3 NR3C1 RAD21 FOXA1 HNF1A RNU5E-3P FRYL OCIAD1 OCIAD1-AS1 SLC10A4 NFXL1 GC04P048658
GH04G048775 1.6 Ensembl ENCODE dbSUPER 0.7 +1.9 1889 6.8 FOXA2 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZBTB7B YY1 ZNF766 OCIAD1 TEC SLC10A4 NFXL1 FRYL GC04P048658
GH04G048849 0.5 FANTOM5 2 -69.2 -69235 0.3 FOSL1 ATF3 FOS OCIAD1 OCIAD2 ZAR1 FRYL OCIAD1-AS1
GH04G048697 1.5 Ensembl ENCODE dbSUPER 0.2 +80.7 80673 4.5 PKNOX1 FOXA2 ATF1 ARNT YY1 TCF12 ZNF121 GATA2 FOS MAFF OCIAD1 SLC10A4 CWH43 GC04P048658 FRYL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FRYL on UCSC Golden Path with GeneCards custom track

Promoters for FRYL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168161 522 3201 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZBTB7B YY1 ZNF766 ZNF143

Genomic Location for FRYL Gene

Chromosome:
4
Start:
48,497,361 bp from pter
End:
48,780,322 bp from pter
Size:
282,962 bases
Orientation:
Minus strand

Genomic View for FRYL Gene

Genes around FRYL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRYL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRYL Gene

Proteins for FRYL Gene

  • Protein details for FRYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94915-FRYL_HUMAN
    Recommended name:
    Protein furry homolog-like
    Protein Accession:
    O94915
    Secondary Accessions:
    • O95640
    • Q8WTZ5
    • Q9NT40

    Protein attributes for FRYL Gene

    Size:
    3013 amino acids
    Molecular mass:
    339598 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRYL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRYL Gene

Post-translational modifications for FRYL Gene

  • Ubiquitination at isoforms=2232, isoforms=2240, and Lys2279
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FRYL Gene

Domains & Families for FRYL Gene

Protein Domains for FRYL Gene

Suggested Antigen Peptide Sequences for FRYL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94915

UniProtKB/Swiss-Prot:

FRYL_HUMAN :
  • Belongs to the furry protein family.
Family:
  • Belongs to the furry protein family.
genes like me logo Genes that share domains with FRYL: view

No data available for Gene Families for FRYL Gene

Function for FRYL Gene

Molecular function for FRYL Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.

Phenotypes for FRYL Gene

MGI mutant phenotypes for FRYL:
inferred from 1 alleles
GenomeRNAi human phenotypes for FRYL:
genes like me logo Genes that share phenotypes with FRYL: view

Animal Models for FRYL Gene

MGI Knock Outs for FRYL:
  • Fryl tm1a(KOMP)Wtsi

Animal Model Products

CRISPR Products

miRNA for FRYL Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRYL Gene

Localization for FRYL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRYL gene
Compartment Confidence
cytosol 4
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FRYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005938 cell cortex IBA --
GO:0030427 site of polarized growth IBA --
genes like me logo Genes that share ontologies with FRYL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FRYL Gene

Pathways & Interactions for FRYL Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0031175 neuron projection development IBA --
GO:0090527 actin filament reorganization IBA --
genes like me logo Genes that share ontologies with FRYL: view

No data available for Pathways by source and SIGNOR curated interactions for FRYL Gene

Transcripts for FRYL Gene

mRNA/cDNA for FRYL Gene

(11) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRYL Gene

FRY-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRYL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: -
SP2:
SP3:
SP4: -
SP5:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
SP1: - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for FRYL Gene

GeneLoc Exon Structure for
FRYL
ECgene alternative splicing isoforms for
FRYL

Expression for FRYL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRYL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FRYL Gene

This gene is overexpressed in Breast (17.9) and Peripheral blood mononuclear cells (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FRYL Gene



Protein tissue co-expression partners for FRYL Gene

NURSA nuclear receptor signaling pathways regulating expression of FRYL Gene:

FRYL

SOURCE GeneReport for Unigene cluster for FRYL Gene:

Hs.595553

mRNA Expression by UniProt/SwissProt for FRYL Gene:

O94915-FRYL_HUMAN
Tissue specificity: Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin.

Evidence on tissue expression from TISSUES for FRYL Gene

  • Nervous system(4.6)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FRYL: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRYL Gene

Orthologs for FRYL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FRYL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRYL 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia FRYL 34 35
  • 93.49 (n)
cow
(Bos Taurus)
Mammalia FRYL 34 35
  • 93.15 (n)
oppossum
(Monodelphis domestica)
Mammalia FRYL 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRYL 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fryl 34 16 35
  • 86.62 (n)
rat
(Rattus norvegicus)
Mammalia Fryl 34
  • 86.36 (n)
chicken
(Gallus gallus)
Aves FRYL 34 35
  • 84.54 (n)
lizard
(Anolis carolinensis)
Reptilia FRYL 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fryl 34
  • 79.54 (n)
zebrafish
(Danio rerio)
Actinopterygii fryl 34 35
  • 70.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta fry 34
  • 52.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004892 34
  • 50.81 (n)
worm
(Caenorhabditis elegans)
Secernentea sax-2 34
  • 46.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAO3 35
  • 20 (a)
OneToMany
Species where no ortholog for FRYL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRYL Gene

ENSEMBL:
Gene Tree for FRYL (if available)
TreeFam:
Gene Tree for FRYL (if available)

Paralogs for FRYL Gene

Paralogs for FRYL Gene

(6) SIMAP similar genes for FRYL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FRYL: view

Variants for FRYL Gene

Sequence variations from dbSNP and Humsavar for FRYL Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000043394 -- 48,756,163(+) GGGAG(A/G)TCAAG intron-variant
rs1000051785 -- 48,522,403(+) CTTCT(A/T)TACAG intron-variant
rs1000056313 -- 48,615,860(+) ACATA(C/T)ACACC intron-variant
rs1000079991 -- 48,651,497(+) TCTCT(A/G)GACTC intron-variant
rs1000088466 -- 48,616,238(+) ACTGG(C/G)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRYL Gene

Variant ID Type Subtype PubMed ID
dgv322e215 CNV deletion 23714750
dgv6e22 CNV deletion 17803354
dgv9032n54 CNV loss 21841781
dgv9033n54 CNV loss 21841781
dgv9034n54 CNV loss 21841781
dgv9035n54 CNV loss 21841781
dgv9036n54 CNV loss 21841781
esv2581662 CNV deletion 19546169
esv2676381 CNV deletion 23128226
esv2727542 CNV deletion 23290073
esv27329 CNV loss 19812545
esv3337856 CNV insertion 20981092
esv33592 CNV loss 17666407
esv3563841 CNV deletion 23714750
esv3569415 CNV loss 25503493
esv3569416 CNV loss 25503493
esv3600466 CNV loss 21293372
esv3600467 CNV loss 21293372
esv3600468 CNV loss 21293372
esv989650 CNV deletion 20482838
nsv1010381 CNV gain 25217958
nsv1073756 CNV deletion 25765185
nsv1123783 CNV deletion 24896259
nsv1126686 CNV deletion 24896259
nsv1143286 CNV deletion 24896259
nsv470034 CNV gain 18288195
nsv513131 CNV loss 21212237
nsv594121 CNV gain 21841781
nsv594137 CNV loss 21841781
nsv822558 CNV loss 20364138
nsv829925 CNV gain+loss 17160897
nsv966557 CNV deletion 23825009
nsv999203 CNV gain 25217958

Variation tolerance for FRYL Gene

Residual Variation Intolerance Score: 1.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRYL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRYL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRYL Gene

Disorders for FRYL Gene

UniProtKB/Swiss-Prot

FRYL_HUMAN
  • Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein. {ECO:0000269 PubMed:16061630}.

Relevant External Links for FRYL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRYL

No disorders were found for FRYL Gene.

No data available for MalaCards and Genatlas for FRYL Gene

Publications for FRYL Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PMID: 23022380) Yatim A. … Benkirane M. (Mol. Cell 2012) 2 3 64
  3. AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner. (PMID: 16061630) Hayette S. … Rimokh R. (Cancer Res. 2005) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for FRYL Gene

Sources for FRYL Gene

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