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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FRYL Gene

protein-coding GIFtS: 46
GCID: GC04M048499

FRY-like

(Previous names: KIAA0826, furry homolog-like (Drosophila) )
(Previous symbol: KIAA0826)

Explore 11 diseases affiliated with
FRYL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
FRY-Like¹		Furry Homolog-Like²
KIAA0826¹ ² ³		Furry-Like¹
ALL1-Fused Gene From Chromosome 4p12 Protein² ³		Protein Furry Homolog-Like²
DKFZp686E205¹		AF4P12³
Furry Homolog-Like (Drosophila)¹

External Ids:	HGNC: 29127¹	Entrez Gene: 285527²	Ensembl: ENSG00000075539⁷	UniProtKB: O94915³

Export aliases for FRYL gene to outside databases

Previous GC identifers: GC04M048342 GC04M048194 GC04M047819

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915

Function: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates

the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance

between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a

transcriptional activator

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_006238.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FRYL gene promoter:
CUTL1 HNF-3beta E47 C/EBPalpha GATA-2 AREB6 S8 FOXO4 En-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FRYL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRYL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p11 Ensembl cytogenetic band: 4p11 HGNC cytogenetic band: 4p12

FRYL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRYL gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M048499: view genomic region (about GC identifiers)

Start:	48,499,378 bp from pter	End:	48,782,339 bp from pter
Size:	282,962 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915 (See protein sequence)

Recommended Name: Protein furry homolog-like

Size: 3013 amino acids; 339598 Da

Secondary accessions: O95640 Q8WTZ5 Q9NT40

Alternative splicing: 2 isoforms: O94915-1 O94915-2

Explore the universe of human proteins at neXtProt for FRYL: NX_O94915

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94915

FRYL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055845.1

ENSEMBL proteins:

ENSP00000426064 ENSP00000422408 ENSP00000425344 ENSP00000421584 ENSP00000425592

ENSP00000422988 ENSP00000351113 ENSP00000441114 ENSP00000264319

Human Recombinant Protein Products for FRYL:

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	Uscn Proteins for FRYL

FRYL Antibody Products:

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Assay Products for FRYL:

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	Uscn ELISAs and CLIAs for FRYL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FRYL for domains About GeneDecksing

4 InterPro domains/families:

IPR011989 ARM-like

IPR025614 Cell_morpho_N

IPR025481 Cell_Morphogen_C

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry O94915

ProtoNet protein and cluster: O94915

UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915

Similarity: Belongs to the furry protein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FRYL_HUMAN, O94915

Function: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates

the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance

between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a

transcriptional activator

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

FRYL for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Fryl):

mortality/aging

FRYL for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FRYL

miRNA Products:		OriGene 3'-UTR Clone: FRYL Browse MicroRNA Expression Plasmids
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		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate FRYL (see all 56):
		hsa-miR-607 hsa-miR-146a hsa-miR-15a hsa-miR-128 hsa-miR-25 hsa-miR-16-1* hsa-miR-624* hsa-miR-624

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRYL (see all 5) OriGene siRNA: FRYL
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRYL (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRYL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sirion Biotech Customized stable knockdown cell line services for FRYL Sirion Biotech Customized inducible knockdown cell line services for FRYL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRYL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FRYL

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/50 Interacting proteins for FRYL (O94915^{1, 2, 3} ENSP00000351113⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAB	P31946¹^,²^,³, ENSP00000300161⁴	EBI-1104821,EBI-359815 MINT-50946 I2D: score=3 STRING: ENSP00000300161
BAK1	Q16611¹^,³, ENSP00000363591⁴	EBI-1104821,EBI-519866 I2D: score=2 STRING: ENSP00000363591
YWHAG	P61981¹^,³, ENSP00000306330⁴	EBI-1104821,EBI-359832 I2D: score=2 STRING: ENSP00000306330
DISC1	Q9NRI5³, ENSP00000355596⁴	I2D: score=2 STRING: ENSP00000355596
HOMER3	Q9NSC5³, ENSP00000348150⁴	I2D: score=2 STRING: ENSP00000348150

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

FRYL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FRYL
Search CenterWatch for drugs/clinical trials and news about FRYL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FRYL gene (2 alternative transcripts):

NM_001039751.1 NM_015030.1

Unigene Cluster for FRYL:

FRY-like

Hs.595553 [show with all ESTs]

Unigene Representative Sequence: NM_015030

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000503238(uc003gyf.1 uc003gyi.1) ENST00000507873 ENST00000503339(uc003gye.1)

ENST00000512810 ENST00000514617 ENST00000513401(uc003gyj.1) ENST00000512297

ENST00000502925 ENST00000507711(uc003gyk.3) ENST00000511343 ENST00000506685

ENST00000302806(uc003gyl.1) ENST00000505759 ENST00000505437 ENST00000502520

ENST00000514783(uc003gyn.3) ENST00000509886 ENST00000515684

miRNA Products:		OriGene 3'-UTR Clone: FRYL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRYL
		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate FRYL (see all 56):
		hsa-miR-607 hsa-miR-146a hsa-miR-15a hsa-miR-128 hsa-miR-25 hsa-miR-16-1* hsa-miR-624* hsa-miR-624

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRYL (see all 5) OriGene siRNA: FRYL
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRYL (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRYL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FRYL (NM_015030)
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Additional cDNA sequence:

AB020633.1 AK025034.1 AK127307.1 AK128452.1 AK131250.1 AL137546.1 AL833170.1 AL833444.1

BC021803.1 BC040987.2 BC050336.1 CR627228.1 DQ299937.1 DQ299938.1 DQ299939.1 DQ299940.1

U80082.1

22 DOTS entries:

DT.92006270 DT.100777997 DT.95227718 DT.100777999 DT.121256117 DT.121256039 DT.440252 DT.91666820

DT.101964149 DT.445485 DT.95071262 DT.97784386 DT.121256066 DT.100740400 DT.100809875 DT.40111033

DT.95254737 DT.99958352 DT.40114782 DT.40122360 DT.91884207 DT.92057228

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FRYL About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22a	·	22b	^
SP1:																	-
SP2:
SP3:
SP4:																															-
SP5:

ExUns:	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31a	·	31b
SP1:	-										-
SP2:
SP3:											-
SP4:
SP5:

ECgene alternative splicing isoforms for FRYL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FRYL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTGGAGTC

About this image

FRYL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Podocyte Layer

Podocytes

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FRYL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FRYL

SOURCE GeneReport for Unigene cluster: Hs.595553

UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915

Tissue specificity: Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin

SABiosciences Custom PCR Arrays for FRYL

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRYL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FRYL gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fryl^{1 , 5}	furry homolog-like (Drosophila)^{1, 5}	86.63(n)¹ 94.74(a)¹		5 (38.44 cM)⁵ 72313¹ NM_028194.2¹ NP_082470.2¹ 73020322⁵
chicken (Gallus gallus)	Aves	FRYL¹	FRY-like	84.57(n) 92.07(a)		422765 XM_003641236.1 XP_003641284.1
lizard (Anolis carolinensis)	Reptilia	FRYL⁶	--	88(a)	1 ↔ 1	GL343293.1(890315-999187)
zebrafish (Danio rerio)	Actinopterygii	fryl¹	furry homolog-like (Drosophila)	70.87(n) 81.64(a)		558173 NM_001159667.1 NP_001153139.1
fruit fly (Drosophila melanogaster)	Insecta	fry¹	furry	44.14(n) 34.13(a)		39122 NM_168357.3 NP_729520.1
worm (Caenorhabditis elegans)	Secernentea	sax-2¹	Protein SAX-2	45.61(n) 33.63(a)		175697 NM_171117.3 NP_741131.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G15680⁶	armadillo/beta-catenin-like repeat-containing prot...	20(a)	1 → many	5(5100984-5111029)
rice (Oryza sativa)	Liliopsida	--	expressed protein	20(a)	1 → many	2(35712181-35724695)

ENSEMBL Gene Tree for FRYL (if available)
TreeFam Gene Tree for FRYL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FRYL gene

FRY²

5 SIMAP similar genes for FRYL using alignment to 6 protein entries: FRYL_HUMAN (see all proteins):

DKFZp781A0295 FRY DKFZp686K08123 214K23.2 WUGSC

FRYL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182604509^1,2		--	48499033(+)	`TTTGCC/TACACC`	1	--	ds500¹		0	--	--	--	--
rs188023931^1,2		--	48499126(+)	`ACTGCC/TGGATT`	1	--	ds500¹		0	--	--	--	--
rs147023375^1,2		--	48499316(+)	`GAGAAA/GTGTAG`	1	--	ds500¹		0	--	--	--	--
rs138560426^1,2		--	48499413(+)	`TAATAA/GACTTA`	1	--	ut3¹		0	--	--	--	--
rs144135465^1,2		--	48499554(+)	`AATCAC/TTCATT`	1	--	ut3¹		0	--	--	--	--
rs143384146^1,2		--	48499633(+)	`GGGTAA/GGAAAA`	1	--	ut3¹		0	--	--	--	--
rs148363483^1,2		--	48499907(+)	`GCATAC/TGTAAT`	1	--	ut3¹		0	--	--	--	--
rs191663612^1,2		--	48499938(+)	`CACCCC/TCCAAG`	1	--	ut3¹		0	--	--	--	--
rs116199636^1,2	F	--	48500178(+)	`AGACAG/CTGAAT`	1	--	ut3¹		1		NA	120
rs182630271^1,2		--	48500397(+)	`TTCTTA/GTATAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FRYL (48499378 - 48749378 bp, first 250kb of FRYL)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for FRYL
3 CNVs: 4393 63818 98708
3 Indels: 27663 27662 11236

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRYL

DNA2.0 Custom Variant and Variant Library Synthesis for FRYL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FRYL for disorders About GeneDecksing

UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915

Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL).

Translocation t(4;11)(p12;q23) that forms a MLL-FRYL fusion protein

11 diseases for FRYL: About MalaCards

acute lymphoblastic leukemia lymphoblastic leukemia acute myeloid leukemia retinitis pigmentosa

myeloid leukemia myelodysplastic syndrome leukemia neuroblastoma

retinitis schizophrenia neuronitis

Export disorders for FRYL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FRYL gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with FRYL)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T....Ohara O. (1998)
AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner. (PubMed id 16061630)^{1, 2} Hayette S.... Rimokh R. (2005)
Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)¹ Wu Z....Ma L. (2012)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)¹ Yatim A....Benkirane M. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 285527	HGNC: 29127	Ensembl:ENSG00000075539	euGenes: HUgn285527	ECgene: FRYL
H-InvDB: FRYL

(According to HUGE)
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HUGE: KIAA0826

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FRYL	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FRYL	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FRYL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FRYL gene:
Search GeneIP for patents involving FRYL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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FRYL Gene

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