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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FRYL Gene

protein-coding   GIFtS: 47
GCID: GC04M048499

FRY-Like

(Previous names: KIAA0826, furry homolog-like (Drosophila))
(Previous symbol: KIAA0826)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FRY-like1 2     Furry Homolog-Like2
KIAA08261 2 3     furry-like2
ALL1-Fused Gene From Chromosome 4p12 Protein2 3     Protein Furry Homolog-Like2
Furry Homolog-Like (Drosophila)1     AF4P123

External Ids:    HGNC: 291271   Entrez Gene: 2855272   Ensembl: ENSG000000755397   UniProtKB: O949153   

Export aliases for FRYL gene to outside databases

Previous GC identifers: GC04M048342 GC04M048194 GC04M047819


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FRYL Gene: 
FRYL (FRY-like) is a protein-coding gene. Diseases associated with FRYL include retinitis pigmentosa, and myelodysplastic syndromes. An important paralog of this gene is FRY.

UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915
Function: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis,
regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting
avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function
as a transcriptional activator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006238.11  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FRYL gene promoter:
         CUTL1   HNF-3beta   E47   C/EBPalpha   GATA-2   AREB6   S8   FOXO4   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FRYL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRYL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p11   Ensembl cytogenetic band:  4p11   HGNC cytogenetic band: 4p12

FRYL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRYL gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M048499:  view genomic region     (about GC identifiers)

Start:
48,499,378 bp from pter      End:
48,782,339 bp from pter
Size:
282,962 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915 (See protein sequence)
Recommended Name: Protein furry homolog-like  
Size: 3013 amino acids; 339598 Da
Secondary accessions: O95640 Q8WTZ5 Q9NT40
Alternative splicing: 2 isoforms:  O94915-1   O94915-2   

Explore the universe of human proteins at neXtProt for FRYL: NX_O94915

Explore proteomics data for FRYL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94915

  • FRYL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FRYL Protein Expression
    REFSEQ proteins: NP_055845.1  
    ENSEMBL proteins: 
     ENSP00000426064   ENSP00000422408   ENSP00000425344   ENSP00000421584   ENSP00000425592  
     ENSP00000422988   ENSP00000351113   ENSP00000441114   ENSP00000264319  

    Human Recombinant Protein Products for FRYL: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for FRYL 


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    Assay Products for FRYL: 
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    Cloud-Clone Corp. ELISAs for FRYL 
    Cloud-Clone Corp. CLIAs for FRYL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR025614 Cell_morpho_N
     IPR025481 Cell_Morphogen_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O94915

    ProtoNet protein and cluster: O94915

    UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915
    Similarity: Belongs to the furry protein family


    FRYL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRYL_HUMAN, O94915
    Function: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis,
    regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting
    avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function
    as a transcriptional activator

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    FRYL for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fryl):
     mortality/aging 

    FRYL for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FRYL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FRYL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FRYL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FRYL 

    miRNA
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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate FRYL (see all 56):
    hsa-miR-607 hsa-miR-146a hsa-miR-15a hsa-miR-128 hsa-miR-25 hsa-miR-16-1* hsa-miR-624* hsa-miR-624
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRYL

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRYL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FRYL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/50 Interacting proteins for FRYL (O949151, 2, 3 ENSP000003511134) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319461, 2, 3, ENSP000003001614EBI-1104821,EBI-359815 MINT-50946 I2D: score=3 STRING: ENSP00000300161
    BAK1Q166111, 3, ENSP000003635914EBI-1104821,EBI-519866 I2D: score=2 STRING: ENSP00000363591
    YWHAGP619811, 3, ENSP000003063304EBI-1104821,EBI-359832 I2D: score=2 STRING: ENSP00000306330
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    HOMER3Q9NSC53, ENSP000003481504I2D: score=2 STRING: ENSP00000348150
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    FRYL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FRYL

    Search CenterWatch for drugs/clinical trials and news about FRYL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FRYL gene (2 alternative transcripts): 
    NM_001039751.1  NM_015030.1  

    Unigene Cluster for FRYL:

    FRY-like
    Hs.595553  [show with all ESTs]
    Unigene Representative Sequence: NM_015030
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000503238(uc003gyf.1 uc003gyi.1) ENST00000507873 ENST00000503339(uc003gye.1)
    ENST00000512810 ENST00000514617 ENST00000513401(uc003gyj.1) ENST00000512297
    ENST00000502925 ENST00000507711(uc003gyk.3) ENST00000511343 ENST00000506685
    ENST00000302806(uc003gyl.1) ENST00000505759 ENST00000505437 ENST00000502520
    ENST00000514783(uc003gyn.3) ENST00000509886 ENST00000515684
    miRNA
    Products:
         
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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate FRYL (see all 56):
    hsa-miR-607 hsa-miR-146a hsa-miR-15a hsa-miR-128 hsa-miR-25 hsa-miR-16-1* hsa-miR-624* hsa-miR-624
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FRYL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRYL
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    GenScript: all cDNA clones in your preferred vector: FRYL (NM_015030)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRYL
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    OriGene qSTAR qPCR primer pairs in human, mouse for FRYL
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRYL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRYL

    Additional mRNA sequence: 

    AB020633.1 AK025034.1 AK127307.1 AK128452.1 AK131250.1 AL137546.1 AL833170.1 AL833444.1 
    BC021803.1 BC040987.2 BC050336.1 CR627228.1 DQ299937.1 DQ299938.1 DQ299939.1 DQ299940.1 
    U80082.1 

    22 DOTS entries:

    DT.92006270  DT.100777997  DT.95227718  DT.100777999  DT.121256117  DT.121256039  DT.440252  DT.91666820 
    DT.101964149  DT.445485  DT.95071262  DT.97784386  DT.121256066  DT.100740400  DT.100809875  DT.40111033 
    DT.95254737  DT.99958352  DT.40114782  DT.40122360  DT.91884207  DT.92057228 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FRYL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
    SP1:                                                  -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                            -                                                               
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
    SP1:  -                             -                                 
    SP2:                                                                  
    SP3:                                -                                 
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for FRYL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FRYL expression in normal human tissues (normalized intensities)      FRYL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGGAGTC
    FRYL Expression
    About this image


    FRYL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Substantia Nigra   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Proerythroblasts Hematopoietic Bone Marrow
             stem cells (umbilical cord cd34+)   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Gonad
             Secondary Oocyte Antral Follicle

    See FRYL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FRYL

    SOURCE GeneReport for Unigene cluster: Hs.595553

    UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915
    Tissue specificity: Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin

        SABiosciences Custom PCR Arrays for FRYL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRYL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FRYL gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fryl1 , 5 furry homolog-like (Drosophila)1, 5 86.63(n)1
    94.74(a)1
      5 (38.44 cM)5
    723131  NM_028194.21  NP_082470.21 
     730203225 
    chicken
    (Gallus gallus)
    Aves FRYL1 FRY-like 84.57(n)
    92.07(a)
      422765  XM_003641236.1  XP_003641284.1 
    lizard
    (Anolis carolinensis)
    Reptilia FRYL6
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343293.1(890315-999187)
    zebrafish
    (Danio rerio)
    Actinopterygii fryl1 furry homolog-like (Drosophila) 70.87(n)
    81.64(a)
      558173  NM_001159667.1  NP_001153139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fry1 furry 44.14(n)
    34.13(a)
      39122  NM_168357.3  NP_729520.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sax-21 Protein SAX-2 45.61(n)
    33.63(a)
      175697  NM_171117.3  NP_741131.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAO36
    Component of the RAM signaling network that is inv...
    18(a)
    1 → many
    IX(106107-113237)


    ENSEMBL Gene Tree for FRYL (if available)
    TreeFam Gene Tree for FRYL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FRYL gene
    FRY2  
    5 SIMAP similar genes for FRYL using alignment to 6 protein entries:     FRYL_HUMAN (see all proteins):
    DKFZp781A0295    FRY    DKFZp686K08123    214K23.2    WUGSC

    FRYL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4818 SNPs in FRYL are shown (see all 4818)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0669944
    ----see VAR_0669942 P S mis40--------
    rs1826045091,2
    --48499033(+) TTTGCC/TACACC 1 -- ds50010--------
    rs1880239311,2
    --48499126(+) ACTGCC/TGGATT 1 -- ds50010--------
    rs1470233751,2
    --48499316(+) GAGAAA/GTGTAG 1 -- ds50010--------
    rs1385604261,2
    --48499413(+) TAATAA/GACTTA 1 -- ut310--------
    rs1441354651,2
    --48499554(+) AATCAC/TTCATT 1 -- ut310--------
    rs1433841461,2
    --48499633(+) GGGTAA/GGAAAA 1 -- ut310--------
    rs1483634831,2
    --48499907(+) GCATAC/TGTAAT 1 -- ut310--------
    rs1916636121,2
    --48499938(+) CACCCC/TCCAAG 1 -- ut310--------
    rs1161996361,2
    C,F--48500178(+) AGACAG/CTGAAT 1 -- ut311Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for FRYL (48499378 - 48749378 bp, first 250kb of FRYL)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for FRYL (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676381CNV Deletion23128226
    dgv6e22CNV Deletion17803354
    esv2581662CNV Deletion19546169
    esv989650CNV Deletion20482838
    esv2727542CNV Deletion23290073
    esv33592CNV Loss17666407
    nsv513131CNV Loss21212237
    esv27329CNV Loss19812545
    nsv822558CNV Loss20364138
    nsv470034CNV Gain18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UniProtKB/Swiss-Prot: FRYL_HUMAN, O94915
  • Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia
    (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein

  • 11 diseases for FRYL:    About MalaCards
    retinitis pigmentosa    myelodysplastic syndromes    retinitis    acute lymphoblastic leukemia
    lymphoblastic leukemia    acute myeloid leukemia    myeloid leukemia    schizophrenia
    leukemia    neuroblastoma    neuronitis


    FRYL for disorders           About GeneDecksing


    Export disorders for FRYL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FRYL gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with FRYL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    2. AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner. (PubMed id 16061630)1, 2 Hayette S.... Rimokh R. (2005)
    3. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    4. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    5. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    8. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285527 HGNC: 29127 Ensembl:ENSG00000075539 euGenes: HUgn285527 ECgene: FRYL
    H-InvDB: FRYL

    (According to HUGE)
    About This Section
    HUGE: KIAA0826

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FRYL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FRYL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FRYL gene:
    Search GeneIP for patents involving FRYL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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