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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FRY Gene

protein-coding   GIFtS: 52
GCID: GC13P032605

Furry Homolog (Drosophila)

(Previous name: chromosome 13 open reading frame 14)
(Previous symbol: C13orf14)
  3 related diseases
at
MalaCards
 

Aliases
for FRY gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Furry Homolog (Drosophila)1 2     CG0032
C13orf141 2 3     WUGSC:H_2G3A.12
Chromosome 13 Open Reading Frame 141     bA207N4.22
13CDNA732     bA37E23.12
214K23.22     Protein Furry Homolog2

External Ids:    HGNC: 203671   Entrez Gene: 101292   Ensembl: ENSG000000739107   OMIM: 6148185   UniProtKB: Q5TBA93   

Export aliases for FRY gene to outside databases

Previous GC identifers: GC13P031504 GC13P013416


Summaries
for FRY gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for FRY Gene: 
FRY (furry homolog (Drosophila)) is a protein-coding gene. Diseases associated with FRY include glottis carcinoma, and diphyllobothriasis. An important paralog of this gene is FRYL.

UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9
Function: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle
bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the
interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation




Genomic Views
for FRY gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FRY gene promoter:
         FOXO3   Nkx5-1   RORalpha2   GATA-1   Evi-1   FOXO3b   AREB6   FOXJ2 (long isoform)   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FRY promoter sequence
   Search SABiosciences Chromatin IP Primers for FRY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1   Ensembl cytogenetic band:  13q13.1   HGNC cytogenetic band: 13q13.1

FRY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRY gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P032605:  view genomic region     (about GC identifiers)

Start:
 32,605,437 bp from pter      End:
 32,870,794 bp from pter
Size:
 265,358 bases      Orientation:
 plus strand

Proteins
for FRY gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9 (See protein sequence)
Recommended Name: Protein furry homolog  
Size: 3013 amino acids; 338875 Da
Subunit: When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in
interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the
separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to
spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to
separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell
cycle
Sequence caution: Sequence=CAB42442.1; Type=Frameshift; Positions=1340, 1378;
Secondary accessions: Q9Y3N6

Explore the universe of human proteins at neXtProt for FRY: NX_Q5TBA9

Explore proteomics data for FRY at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by AURKA, CDK1 and PLK1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TBA9

    • FRY Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FRY Protein Expression
    REFSEQ proteins: NP_075463.2  
    ENSEMBL proteins: 
     ENSP00000369600   ENSP00000398010   ENSP00000434694   ENSP00000369565   ENSP00000445043  

    Human Recombinant Protein Products for FRY: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FRY 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--

    FRY for ontologies           About GeneDecksing



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    Novus Biologicals FRY Antibody
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    Assay Products for FRY: 
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    Protein Domains /
    Families
    for FRY gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR025614 Cell_morpho_N
     IPR025481 Cell_Morphogen_C

    Graphical View of Domain Structure for InterPro Entry Q5TBA9

    ProtoNet protein and cluster: Q5TBA9

    1 Blocks protein domain: IPB006203 GHMP kinase

    UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9
    Similarity: Belongs to the furry protein family


    FRY for domains           About GeneDecksing


    Function
    for FRY gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRY_HUMAN, Q5TBA9
    Function: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle
    bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the
    interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    FRY for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FRY 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FRY

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate FRY (see all 21):
    hsa-miR-137 hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-628-3p hsa-miR-424 hsa-miR-9 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: FRY 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FRY
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for FRY
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    GenScript: all cDNA clones in your preferred vector: FRY (NM_023037)
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    Cell Line
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                         Customized inducible knockdown cell line services for FRY

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRY


    Pathways & Interactions
    for FRY gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FRY

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/9 Interacting proteins for FRY (Q5TBA92, 3 ENSP000003696004) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50897 I2D: score=1 STRING: ENSP00000306330
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AKT3Q9Y2433I2D: score=4 
    ARHGAP1Q079603I2D: score=4 
    MCM5P339923I2D: score=4 
    About this table

    Drugs & Compounds
    for FRY gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FRY

    Search CenterWatch for drugs/clinical trials and news about FRY

    Transcripts
    for FRY gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FRY gene: 
    NM_023037.2  

    Unigene Cluster for FRY:

    Furry homolog (Drosophila)
    Hs.507669  [show with all ESTs]
    Unigene Representative Sequence: NM_023037
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380250(uc001utx.3 uc010tdw.2 uc001utz.3 uc010tdx.2)
    ENST00000463566 ENST00000436046 ENST00000602645 ENST00000477712 ENST00000380217
    ENST00000542859
    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRY
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate FRY (see all 21):
    hsa-miR-137 hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-628-3p hsa-miR-424 hsa-miR-9 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: FRY 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FRY
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRY
    Sirion Biotech Custom design and validation of potent shRNA sequences against FRY
    Clone
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    OriGene ORF clones in mouse, rat for FRY
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRY
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRY
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRY

    Additional mRNA sequence: 

    AK091422.1 AK298021.1 AL049784.1 BX648226.1 U50526.1 U50534.1 U57961.1 

    13 DOTS entries:

    DT.455706  DT.100022238  DT.100810409  DT.70104802  DT.101974982  DT.91739417  DT.91694870  DT.97840666 
    DT.421693  DT.91739396  DT.95164829  DT.99968845  DT.454125 

    24/134 AceView cDNA sequences (see all 134):

    BM677315 NM_023037 BU733162 AK091422 BM707606 BM721728 CB528947 CR621863 
    AI221603 D79325 BX441369 BQ015530 AI801267 BX641976 BI766462 BE615040 
    BE614799 AA804739 AL049784 BG210974 AA350131 BX494316 CA952510 AA740292 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FRY (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:              -                                                                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 51 ^ 52a · 52b · 52c ^ 53 ^ 54 ^ 55a · 55b ^ 56a · 56b · 56c ^ 57 ^ 58 ^ 59a · 59b ^ 60 ^ 61 ^ 62 ^ 63a · 63b
    SP1:        -     -                             -                                         -     -                           
    SP2:                                                                                                                        
    SP3:                                            -                                                                           
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for FRY

    Expression
    for FRY gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FRY expression in normal human tissues (normalized intensities)      FRY embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACTTGTT
    FRY Expression
    About this image


    FRY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             ganglion/cranial/facial VII
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             fetal cartilage
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
     
     Reproductive System (Reproductive System)
             endometrial endothelial cell
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion

    See FRY Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FRY

    SOURCE GeneReport for Unigene cluster: Hs.507669
        SABiosciences Custom PCR Arrays for FRY
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for FRY gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FRY gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fry1 , 5 furry homolog (Drosophila)1, 5 87.14(n)1
    96.81(a)1    		   5 (89.36 cM)5
    3203651  NM_172887.21  NP_766475.21 
     1502599305 
    chicken
    (Gallus gallus)    		 Aves FRY1 furry homolog (Drosophila) 82.26(n)
    93.75(a)    		   418915  XM_003640579.1  XP_003640627.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FRY6
    		 furry homolog (Drosophila)
    		 92(a)
    		 1 ↔ 1
    		 3(183765981-183960420)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.86932 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_075463.1 (H.sapiens) hypothetical protein CG003 [Homo sapiens] less 79.46(n)    BJ070503.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fryb1 furry homolog b (Drosophila) 71.52(n)
    79.03(a)    		   792949  XM_001332213.4  XP_001332249.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fry6
    		 furry
    		 31(a)
    		 1 → many
    		 3L(9624934-9672203)
    worm
    (Caenorhabditis elegans)    		 Secernentea sax-26
    		 Protein SAX-2, isoform a
    		 28(a)
    		 1 → many
    		 III(5109701-5130675)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TAO36
    		 Component of the RAM signaling network that is inv...
    		 17(a)
    		 1 → many
    		 IX(106107-113237)


    ENSEMBL Gene Tree for FRY (if available)
    TreeFam Gene Tree for FRY (if available)

    Paralogs
    for FRY gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FRY gene
    FRYL2  
    5 SIMAP similar genes for FRY using alignment to 6 protein entries:     FRY_HUMAN (see all proteins):
    DKFZp686K08123    214K23.2    FRYL    DKFZp781A0295    WUGSC

    FRY for paralogs           About GeneDecksing



    Genomic Variants
    for FRY gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5438 SNPs in FRY are shown (see all 5438)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs665582301,2
    		C--13680597(+) AAAAA-/AAA   
           /AAAA    CAGAT     		2 -- int1 cds11NA 2
    rs1864739251,2
    		--32608143(+) ACCTTA/GGCTGA 1 -- int10--------
    rs1910109921,2
    		--32608355(+) TTTTGC/TAAGGT 1 -- int10--------
    rs2041261,2
    		C,F,O,A,H--32608479(+) TCACAG/AGCCAA 1 -- int135Minor allele frequency- A:0.40NS NA EA WA CSA 3196
    rs1827658441,2
    		--32608480(+) CACAGA/GCCAAT 1 -- int10--------
    rs1877882401,2
    		--32608498(+) TCAGTC/TGCTGG 1 -- int10--------
    rs1403189301,2
    		--32608514(+) GAGATA/GTACTA 1 -- int10--------
    rs1450555881,2
    		--32608530(+) CATTCA/GATGTT 1 -- int10--------
    rs757582221,2
    		--32608547(+) GGTGTA/TCTCCT 1 -- int10--------
    rs1404531831,2
    		--32608707(+) TCCCTG/TCTCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FRY (32605437 - 32855437 bp, first 250kb of FRY)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FRY:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2060908CNV Deletion18987734
    esv2672148CNV Deletion23128226
    esv271217CNV Insertion20981092
    esv273763CNV Insertion20981092
    esv274462CNV Insertion20981092
    nsv519928CNV Loss19592680
    nsv818954CNV Loss17921354


    Human Gene Mutation Database (HGMD): FRY
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRY
    DNA2.0 Custom Variant and Variant Library Synthesis for FRY

    Disorders / Diseases
    for FRY gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FRY for disorders           About GeneDecksing

    OMIM gene information: 614818    OMIM disorders: --

    3 diseases for FRY:    About MalaCards
    glottis carcinoma    diphyllobothriasis    azoospermia

    Genetic Association Database (GAD): FRY
    Human Genome Epidemiology (HuGE) Navigator: FRY (15 documents)

    Export disorders for FRY gene to outside databases

    Publications
    for FRY gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FRY gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with FRY)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Furry protein promotes Aurora A-mediated polo-like kinase 1 activation. (PubMed id 22753416)1, 2 Ikeda M.... Mizuno K. (2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (2004)
    6. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)1, 3 Couch F.J.... Simard J. (1996)
    7. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes. (PubMed id 19327996)1 Chiba S....Mizuno K. (2009)
    10. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)

    External Searches for FRY gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FRY gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10129 HGNC: 20367 AceView: 13CDNA73 Ensembl:ENSG00000073910 euGenes: HUgn10129
    ECgene: FRY H-InvDB: FRY

    Other Databases showing FRY gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FRY gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FRY Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FRY gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FRY gene:
    Search GeneIP for patents involving FRY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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