Aliases for FRY Gene
Aliases for FRY Gene
External Ids for FRY Gene
- HGNC: 20367
- Entrez Gene: 10129
- Ensembl: ENSG00000073910
- OMIM: 614818
- UniProtKB: Q5TBA9
Previous HGNC Symbols for FRY Gene
- C13orf14
Previous GeneCards Identifiers for FRY Gene
- GC13P031504
- GC13P032605
- GC13P013416
Summaries for FRY Gene
GeneCards Summary for FRY Gene
FRY (FRY Microtubule Binding Protein) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is FRYL.
UniProtKB/Swiss-Prot for FRY Gene
-
Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRY Gene
Genomics for FRY Gene
Regulatory Elements for FRY Gene
Enhancers for FRY Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH13G031981 | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 10 | -48.9 | -48864 | 1.2 | FOXA2 NFIB JUN ZNF644 YY1 SCRT2 FOS NFIA BHLHE40 CEBPB | FRY-AS1 FRY N4BP2L1 LINC01073 ENSG00000278732 |
| GH13G031908 | 0.9 | Ensembl ENCODE | 15 | -121.9 | -121928 | 1.7 | TBP CTCF ZNF654 TRIM22 CEBPB MAX JUNB REST RAD21 RFX5 | FRY FRY-AS1 ENSG00000279314 LOC105370152 |
| GH13G032124 | 1.2 | FANTOM5 Ensembl ENCODE | 11.2 | +94.5 | 94455 | 2.1 | CEBPB RCOR1 CUX1 EP300 TCF7L2 | FRY FRY-AS1 N4BP2L2 BRCA2 N4BP2L1 GC13P032060 GC13P032297 |
| GH13G032142 | 1.2 | Ensembl ENCODE | 11.2 | +111.7 | 111743 | 1.1 | FOXA2 ATF1 MLX ZFP64 ARID4B FEZF1 DMAP1 MXD4 NFYC PPARG | FRY-AS1 FRY GC13P032060 GC13P032297 |
| GH13G032080 | 1.1 | ENCODE dbSUPER | 10.8 | +49.4 | 49437 | 1.0 | ELF3 FOXA2 ATF1 ARID4B THRB RARA GATA4 CREM MIXL1 THAP11 | FRY-AS1 FRY GC13P032060 GC13P032297 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FRY on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FRY gene promoter:
Regulatory Element Products
Genomic Location for FRY Gene
- Chromosome:
- 13
- Start:
- 32,031,300 bp from pter
- End:
- 32,299,122 bp from pter
- Size:
- 267,823 bases
- Orientation:
- Plus strand
Genomic View for FRY Gene
Genes around FRY on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q13.1 by Ensembl
- 13q13.1 by Entrez Gene
- 13q13.1 by HGNC
FRY Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FRY Gene
Proteins for FRY Gene
-
Protein details for FRY Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5TBA9-FRY_HUMAN
- Recommended name:
- Protein furry homolog
- Protein Accession:
- Q5TBA9
- Q9Y3N6
Protein attributes for FRY Gene
- Size:
- 3013 amino acids
- Molecular mass:
- 338875 Da
- Quaternary structure:
-
- When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA.
- SequenceCaution:
-
- Sequence=CAB42442.1; Type=Frameshift; Positions=1340, 1378; Evidence={ECO:0000305};
Protein Expression for FRY Gene
Post-translational modifications for FRY Gene
- Phosphorylated by AURKA, CDK1 and PLK1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FRY Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FRY
- Invitrogen Antibodies for FRY
- antibodies-online Antibodies for FRY: See all 8
- Search GeneTex for Antibodies for FRY
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FRY
- Origene Custom Protein Services for FRY
- Novus Biologicals proteins for FRY
- Search GeneTex for Proteins for FRY
No data available for DME Specific Peptides for FRY Gene
Domains & Families for FRY Gene
Protein Domains for FRY Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FRY Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5TBA9- Family:
-
- Belongs to the furry protein family.
No data available for Gene Families for FRY Gene
Function for FRY Gene
Molecular function for FRY Gene
- UniProtKB/Swiss-Prot Function:
- Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004857 | enzyme inhibitor activity | IEA | -- |
Phenotypes for FRY Gene
- GenomeRNAi human phenotypes for FRY:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FRY
-
-
ViGene Biosciences lentiviral particle packaged cDNA for FRY gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FRY gene
- Search ViGene Biosciences for FRY
CRISPR Products
-
OriGene CRISPR knockouts for FRY
-
Santa Cruz Biotechnology (SCBT) CRISPR for FRY
- GenScript: Design CRISPR guide RNA sequences for FRY
miRNA for FRY Gene
- miRTarBase miRNAs that target FRY
-
- hsa-mir-132-3p (MIRT021767)
- hsa-mir-489-3p (MIRT527923)
- hsa-mir-3913-3p (MIRT527924)
- hsa-mir-3973 (MIRT527925)
- hsa-mir-425-5p (MIRT527926)
- hsa-mir-802 (MIRT527927)
- hsa-mir-4517 (MIRT527928)
- hsa-mir-559 (MIRT527929)
- hsa-mir-548y (MIRT527930)
- hsa-mir-548w (MIRT527931)
- hsa-mir-548o-5p (MIRT527932)
- hsa-mir-548j-5p (MIRT527933)
- hsa-mir-548i (MIRT527934)
- hsa-mir-548h-5p (MIRT527935)
- hsa-mir-548d-5p (MIRT527936)
- hsa-mir-548c-5p (MIRT527937)
- hsa-mir-548bb-5p (MIRT527938)
- hsa-mir-548b-5p (MIRT527939)
- hsa-mir-548ay-5p (MIRT527940)
- hsa-mir-548au-5p (MIRT527941)
- hsa-mir-548as-5p (MIRT527942)
- hsa-mir-548ar-5p (MIRT527943)
- hsa-mir-548aq-5p (MIRT527944)
- hsa-mir-548ap-5p (MIRT527945)
- hsa-mir-548am-5p (MIRT527946)
- hsa-mir-548ak (MIRT527947)
- hsa-mir-548ae-5p (MIRT527948)
- hsa-mir-548ad-5p (MIRT527949)
- hsa-mir-548ab (MIRT527950)
- hsa-mir-548a-5p (MIRT527951)
- hsa-mir-511-5p (MIRT640652)
- hsa-mir-4474-5p (MIRT640653)
- hsa-mir-6830-3p (MIRT640654)
- hsa-mir-4509 (MIRT640655)
- hsa-mir-4744 (MIRT640656)
- hsa-mir-186-5p (MIRT640657)
- hsa-mir-3133 (MIRT640658)
miRNA Products
- Search ViGene Biosciences for FRY
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for FRY
- Browse OriGene Inhibitory RNA Products For FRY
-
ViGene Biosciences ready-to-package AAV shRNAs for FRY gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FRY
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FRY
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for FRY
-
ViGene Biosciences adenoviral particle packaged cDNA for FRY gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FRY gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FRY gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRY Gene
Localization for FRY Gene
Subcellular locations from UniProtKB/Swiss-Prot for FRY Gene
- Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| cytoskeleton | 3 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005938 | cell cortex | IBA | -- |
Pathways & Interactions for FRY Gene
No Data Available
Interacting Proteins for FRY Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IBA | -- |
| GO:0031175 | neuron projection development | IBA | -- |
| GO:0043086 | negative regulation of catalytic activity | IEA | -- |
| GO:0090527 | actin filament reorganization | IBA | -- |
| GO:1904428 | negative regulation of tubulin deacetylation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FRY Gene
Transcripts for FRY Gene
mRNA/cDNA for FRY Gene
- (7) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (134) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FRY Gene
CRISPR Products
-
OriGene CRISPR knockouts for FRY
-
Santa Cruz Biotechnology (SCBT) CRISPR for FRY
- GenScript: Design CRISPR guide RNA sequences for FRY
miRNA Products
- Search ViGene Biosciences for FRY
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for FRY
- Browse OriGene Inhibitory RNA Products For FRY
-
ViGene Biosciences ready-to-package AAV shRNAs for FRY gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FRY
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FRY
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 | ^ | 44 | ^ | 45 | ^ | 46 | ^ | 47 | ^ | 48 | ^ | 49 | ^ | 50 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 51 | ^ | 52a | · | 52b | · | 52c | ^ | 53 | ^ | 54 | ^ | 55a | · | 55b | ^ | 56a | · | 56b | · | 56c | ^ | 57 | ^ | 58 | ^ | 59a | · | 59b | ^ | 60 | ^ | 61 | ^ | 62 | ^ | 63a | · | 63b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for FRY Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Mesenchymal Condensate Cells Zeugopod
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Heart (Cardiovascular System)
- Endocardial Tube Cells Endocardium
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Brain (Nervous System)
- Neural Tube (Nervous System)
This gene is overexpressed in Nasal epithelium (53.2) and Bone (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FRY Gene
NURSA nuclear receptor signaling pathways regulating expression of FRY Gene:
FRYSOURCE GeneReport for Unigene cluster for FRY Gene:
Hs.507669Evidence on tissue expression from TISSUES for FRY Gene
- Liver(4.1)
- Nervous system(3.9)
Primer Products
-
OriGene qPCR primer pairs for FRY
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRY Gene
Orthologs for FRY Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FRY 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | FRY 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FRY 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FRY 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fry 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fry 34 |
|
||
| chicken (Gallus gallus) |
Aves | FRY 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FRY 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fry 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8693 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | frya 35 |
|
OneToMany | |
| fryb 34 35 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | fry 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | sax-2 35 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TAO3 35 |
|
OneToMany |
- Species where no ortholog for FRY was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FRY Gene
(6) SIMAP similar genes for FRY Gene using alignment to 6 proteins:
Variants for FRY Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013025 | -- | 32,106,741(+) | ATGTG(C/T)CCGTC | intron-variant | |
| rs1000041285 | -- | 32,205,042(+) | TACTA(A/C)AAATA | intron-variant | |
| rs1000045945 | -- | 32,249,303(+) | ACAAG(C/G)AGTTG | intron-variant | |
| rs1000089376 | -- | 32,217,155(+) | GTTAT(A/G)AGTTA | intron-variant | |
| rs1000115154 | -- | 32,113,620(+) | TGGAA(G/T)AATAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv946n106 | CNV | tandem duplication | 24896259 |
| esv2060908 | CNV | deletion | 18987734 |
| esv2672148 | CNV | deletion | 23128226 |
| esv3306941 | CNV | mobile element insertion | 20981092 |
| esv3309491 | CNV | mobile element insertion | 20981092 |
| esv3310190 | CNV | mobile element insertion | 20981092 |
| esv3373978 | CNV | insertion | 20981092 |
| esv3413949 | CNV | insertion | 20981092 |
| esv3421906 | CNV | insertion | 20981092 |
| esv3428476 | CNV | insertion | 20981092 |
| esv3580596 | CNV | loss | 25503493 |
| esv3580597 | CNV | loss | 25503493 |
| esv3631715 | CNV | loss | 21293372 |
| nsv1129167 | CNV | insertion | 24896259 |
| nsv1138210 | CNV | deletion | 24896259 |
| nsv1150098 | CNV | insertion | 26484159 |
| nsv472285 | CNV | novel sequence insertion | 20440878 |
| nsv519928 | CNV | loss | 19592680 |
| nsv561432 | CNV | loss | 21841781 |
| nsv818954 | CNV | loss | 17921354 |
| nsv952536 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
0.126% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.12;
87.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FRY Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRY Gene
Disorders for FRY Gene
Relevant External Links for FRY
No disorders were found for FRY Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRY Gene
Publications for FRY Gene
- Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. (PMID: 23886946) Nagai T. … Mizuno K. (J. Cell. Sci. 2013) 2 3 64
- Furry protein promotes Aurora A-mediated polo-like kinase 1 activation. (PMID: 22753416) Ikeda M. … Mizuno K. (J. Biol. Chem. 2012) 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 64
Products for FRY Gene
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- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FRY
- Novus Biologicals proteins for FRY
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for FRY
- Search GeneTex for Antibodies for FRY
- Search GeneTex for Proteins for FRY
- ViGene Biosciences adenoviral particle packaged cDNA for FRY gene
- ViGene Biosciences lentiviral particle packaged cDNA for FRY gene
- ViGene Biosciences ready-to-package AAV shRNAs for FRY gene
- Search ViGene Biosciences for FRY
- Horizon Cell Lines for FRY
- Cyagen custom Knockout/knockin (KOKI) mouse models for FRY
- VectorBuilder custom plasmid, inducible vectors for FRY
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FRY
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FRY Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer