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FRY Gene

protein-coding GIFtS: 52
GCID: GC13P032605

Furry Homolog (Drosophila)

(Previous name: chromosome 13 open reading frame 14)
(Previous symbol: C13orf14)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Furry Homolog (Drosophila)¹ ²		CG003²
C13orf14¹ ² ³ ⁵		WUGSC:H_2G3A.1²
Chromosome 13 Open Reading Frame 14¹		bA207N4.2²
13CDNA73²		bA37E23.1²
214K23.2²		Protein Furry Homolog²

External Ids:	HGNC: 20367¹	Entrez Gene: 10129²	Ensembl: ENSG00000073910⁷	OMIM: 614818⁵	UniProtKB: Q5TBA9³

Export aliases for FRY gene to outside databases

Previous GC identifers: GC13P031504 GC13P013416

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FRY Gene:

FRY (furry homolog (Drosophila)) is a protein-coding gene. Diseases associated with FRY include diphyllobothriasis, and azoospermia. An important paralog of this gene is FRYL.

UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9

Function: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of

spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold

promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000013.11 NT_024524.15 NC_018924.2

Regulatory elements:

Regulatory transcription factor binding sites in the FRY gene promoter:
FOXO3 Nkx5-1 RORalpha2 GATA-1 Evi-1 FOXO3b AREB6 FOXJ2 (long isoform) FOXO3a FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FRY promoter sequence

Search Chromatin IP Primers for FRY

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRY

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1 Ensembl cytogenetic band: 13q13.1 HGNC cytogenetic band: 13q13.1

FRY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRY gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P032605: view genomic region (about GC identifiers)

Start:	32,605,437 bp from pter	End:	32,870,794 bp from pter
Size:	265,358 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9 (See protein sequence)

Recommended Name: Protein furry homolog

Size: 3013 amino acids; 338875 Da

Subunit: When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in

interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA

Sequence caution: Sequence=CAB42442.1; Type=Frameshift; Positions=1340, 1378;

Secondary accessions: Q9Y3N6

Explore the universe of human proteins at neXtProt for FRY: NX_Q5TBA9

Explore proteomics data for FRY at MOPED

Post-translational modifications:

Phosphorylated by AURKA, CDK1 and PLK1¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See FRY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_075463.2

ENSEMBL proteins:

ENSP00000369600 ENSP00000398010 ENSP00000434694 ENSP00000369565 ENSP00000445043

FRY Human Recombinant Protein Products:

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FRY Antibody Products:

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	Novus Biologicals FRY Antibody
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FRY Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for FRY
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for FRY Cloud-Clone Corp. CLIAs for FRY

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR025614 Cell_morpho_N

IPR025481 Cell_Morphogen_C

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q5TBA9

ProtoNet protein and cluster: Q5TBA9

1 Blocks protein domain: IPB006203 GHMP kinase

UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9

Similarity: Belongs to the furry protein family

FRY for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: FRY_HUMAN, Q5TBA9

Function: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of

spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold

promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--

FRY for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FRY

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FRY

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FRY

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FRY

miRNA Products:		miRTarBase miRNAs that target FRY: hsa-mir-132-3p (MIRT021767)

		Block miRNA regulation of human, mouse, rat FRY using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate FRY (see all 21):
		hsa-miR-137 hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-628-3p hsa-miR-424 hsa-miR-9 hsa-miR-4325

		SwitchGear 3'UTR luciferase reporter plasmid: FRY 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for FRY
		Predesigned siRNA for gene silencing in human, mouse, rat FRY

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FRY

Clone Products:		OriGene clones in human, mouse for FRY (see all 5) OriGene ORF clones in mouse, rat for FRY OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FRY (NM_023037)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRY
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FRY

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FRY
		Browse ESI BIO Cell Lines and PureStem Progenitors for FRY

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRY

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

FRY_HUMAN, Q5TBA9: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,

cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the

separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase,

to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with

PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages

of the cell cycle

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
plasma membrane	3
cytosol	2
nucleus	2
endoplasmic reticulum	1
mitochondrion	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005815	microtubule organizing center	IEA	--

FRY for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for FRY
Interactions:

Search GeneGlobe Interaction Network for FRY

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for FRY (Q5TBA9^{2, 3} ENSP00000369600⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-50897 I2D: score=1 STRING: ENSP00000306330
SIAH1	Q8IUQ4³, ENSP00000349156⁴	I2D: score=1 STRING: ENSP00000349156
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
AKT3	Q9Y243³	I2D: score=4
ARHGAP1	Q07960³	I2D: score=4

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for FRY

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FRY gene:

NM_023037.2

Unigene Cluster for FRY:

Furry homolog (Drosophila)

Hs.507669 [show with all ESTs]

Unigene Representative Sequence: NM_023037

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380250(uc001utx.3 uc010tdw.2 uc001utz.3 uc010tdx.2)

ENST00000463566 ENST00000436046 ENST00000602645 ENST00000477712 ENST00000380217

ENST00000542859

miRNA Products:		Block miRNA regulation of human, mouse, rat FRY using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate FRY (see all 21):
		hsa-miR-137 hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-628-3p hsa-miR-424 hsa-miR-9 hsa-miR-4325

		SwitchGear 3'UTR luciferase reporter plasmid: FRY 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for FRY
		Predesigned siRNA for gene silencing in human, mouse, rat FRY

Clone Products:		OriGene clones in human, mouse for FRY (see all 5) OriGene ORF clones in mouse, rat for FRY OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FRY (NM_023037)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRY
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FRY

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for FRY
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat FRY
		QuantiTect SYBR Green Assays in human, mouse, rat FRY
		QuantiFast Probe-based Assays in human, mouse, rat FRY

Additional mRNA sequence:

AK091422.1 AK298021.1 AL049784.1 BX648226.1 U50526.1 U50534.1 U57961.1

13 DOTS entries:

DT.455706 DT.100022238 DT.100810409 DT.70104802 DT.101974982 DT.91739417 DT.91694870 DT.97840666

DT.421693 DT.91739396 DT.95164829 DT.99968845 DT.454125

Selected AceView cDNA sequences (see all 134):

D79325 BX441369 BQ015530 AI801267 BX641976 BI766462 BE615040 BE614799

BX494316 CA952510 BM677315 NM_023037 BU733162 AK091422 BM707606 BM721728

CB528947 CR621863 AI221603 BE531155 BI493200 AA740292 AA804739 AL049784

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for FRY (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^
SP1:					-
SP2:
SP3:
SP4:
SP5:

ExUns:	26	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43	^	44	^	45	^	46	^	47	^	48	^	49	^	50	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	51	^	52a	·	52b	·	52c	^	53	^	54	^	55a	·	55b	^	56a	·	56b	·	56c	^	57	^	58	^	59a	·	59b	^	60	^	61	^	62	^	63a	·	63b
SP1:			-		-										-														-		-
SP2:
SP3:															-
SP4:
SP5:

ECgene alternative splicing isoforms for FRY

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FRY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGAACTTGTT

About this image

FRY expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Bone (Muscoskeletal System) fully expand to see all 2 entries
Chondrocytes Zeugopod Epiphyseal End

Cartilage (Muscoskeletal System) fully expand to see all 2 entries
Mesenchymal Condensate Cells Zeugopod

Heart (Cardiovascular System)
Endocardial Tube Cells Endocardium

Limb (Muscoskeletal System)
Mesenchymal Condensate Cells Zeugopod

Blood (Hematopoietic System)
Granulocytes Peripheral Blood

FRY Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

FRY Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.507669

Custom PCR Arrays for FRY

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for FRY
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat FRY
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		QuantiFast Probe-based Assays in human, mouse, rat FRY

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRY

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for FRY gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fry^{1 , 5}	furry homolog (Drosophila)^{1, 5}	87(n)¹ 96.61(a)¹		5 (89.36 cM)⁵ 320365¹ NM_172887.2¹ NP_766475.2¹ 150259930⁵
chicken (Gallus gallus)	Aves	FRY¹	furry homolog (Drosophila)	82.27(n) 93.75(a)		418915 XM_003640579.2 XP_003640627.1
lizard (Anolis carolinensis)	Reptilia	FRY⁶	furry homolog (Drosophila)	92(a)	1 ↔ 1	3(183765981-183960420)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8693²	Xenopus laevis transcribed sequence with moderate similarity to protein refNP_075463.1 (H.sapiens) hypothetical protein CG003 [Homo sapiens] less	79.46(n)		BJ070503.1
zebrafish (Danio rerio)	Actinopterygii	fryb¹	furry homolog b (Drosophila)	71.48(n) 78.95(a)		792949 XM_001332213.5 XP_001332249.2
fruit fly (Drosophila melanogaster)	Insecta	fry⁶	furry	34(a)	1 ↔ 1	3L(9624934-9672203)
worm (Caenorhabditis elegans)	Secernentea	sax-2⁶	Protein SAX-2, isoform a	30(a)	1 ↔ 1	III(5109701-5130675) WBGene00004728
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TAO3⁶	Component of the RAM signaling network that is inv...	20(a)	1 → many	IX(106107-113237) YIL129C

ENSEMBL Gene Tree for FRY (if available)
TreeFam Gene Tree for FRY (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for FRY gene

FRYL²

5 SIMAP similar genes for FRY using alignment to 6 protein entries: FRY_HUMAN (see all proteins):

DKFZp686K08123 214K23.2 FRYL DKFZp781A0295 WUGSC

FRY for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs66558230^1,2	C	--	13680597(+)	`AAAAA-/AAA /AAAACAGAT`	2	--	int¹ cds¹		1		NA	2
rs186473925^1,2		--	32608143(+)	`ACCTTA/GGCTGA`	1	--	int¹		0	--	--	--	--
rs191010992^1,2		--	32608355(+)	`TTTTGC/TAAGGT`	1	--	int¹		0	--	--	--	--
rs204126^1,2	C,F,O,A,H	--	32608479(+)	`TCACAG/AGCCAA`	1	--	int¹		35		NS NA EA WA CSA	3196
rs182765844^1,2		--	32608480(+)	`CACAGA/GCCAAT`	1	--	int¹		0	--	--	--	--
rs187788240^1,2		--	32608498(+)	`TCAGTC/TGCTGG`	1	--	int¹		0	--	--	--	--
rs140318930^1,2		--	32608514(+)	`GAGATA/GTACTA`	1	--	int¹		0	--	--	--	--
rs145055588^1,2		--	32608530(+)	`CATTCA/GATGTT`	1	--	int¹		0	--	--	--	--
rs75758222^1,2		--	32608547(+)	`GGTGTA/TCTCCT`	1	--	int¹		0	--	--	--	--
rs140453183^1,2		--	32608707(+)	`TCCCTG/TCTCTT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FRY (32605437 - 32855437 bp, first 250kb of FRY)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for FRY: About this table

Variant ID	Type	Subtype	PubMed ID
esv2060908	CNV	Deletion	18987734
esv2672148	CNV	Deletion	23128226
esv271217	CNV	Insertion	20981092
esv273763	CNV	Insertion	20981092
esv274462	CNV	Insertion	20981092
nsv519928	CNV	Loss	19592680
nsv818954	CNV	Loss	17921354

Human Gene Mutation Database (HGMD): FRY

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing FRY

DNA2.0 Custom Variant and Variant Library Synthesis for FRY

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614818 OMIM disorders: --

5 diseases for FRY:
About MalaCards

diphyllobothriasis azoospermia cerebritis endotheliitis

neuronitis

FRY for disorders About GeneDecksing

Genetic Association Database (GAD): FRY
Human Genome Epidemiology (HuGE) Navigator: FRY (15 documents)

Export disorders for FRY gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FRY gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with FRY)

Utopia: connect your pdf to the dynamic
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Furry protein promotes Aurora A-mediated polo-like kinase 1 activation. (PubMed id 22753416)^{1, 2} Ikeda M.... Mizuno K. (J. Biol. Chem. 2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (Occup Environ Med 2009)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (Nature 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 3} Ota T.... Sugano S. (Nat. Genet. 2004)
Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)^{1, 3} Couch F.J.... Simard J. (Genomics 1996)
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)¹ Lauc G....Rudan I. (PLoS Genet. 2013)
The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)¹ Varjosalo M....Gstaiger M. (Cell Rep 2013)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes. (PubMed id 19327996)¹ Chiba S....Mizuno K. (Curr. Biol. 2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10129	HGNC: 20367	AceView: 13CDNA73	Ensembl:ENSG00000073910	euGenes: HUgn10129
ECgene: FRY	H-InvDB: FRY

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FRY	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FRY gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FRY gene:
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