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Aliases for FRY Gene

Aliases for FRY Gene

  • FRY Microtubule Binding Protein 2 3 5
  • C13orf14 3 4
  • Chromosome 13 Open Reading Frame 14 2
  • Furry Homolog (Drosophila) 2
  • Protein Furry Homolog 3
  • WUGSC:H_2G3A.1 3
  • Furry Homolog 3
  • BA207N4.2 3
  • BA37E23.1 3
  • 13CDNA73 3
  • 214K23.2 3
  • CG003 3

External Ids for FRY Gene

Previous HGNC Symbols for FRY Gene

  • C13orf14

Previous GeneCards Identifiers for FRY Gene

  • GC13P031504
  • GC13P032605
  • GC13P013416

Summaries for FRY Gene

GeneCards Summary for FRY Gene

FRY (FRY Microtubule Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is FRYL.

UniProtKB/Swiss-Prot for FRY Gene

  • Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.

Additional gene information for FRY Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRY Gene

Genomics for FRY Gene

GeneHancer (GH) Regulatory Elements for FRY Gene

Promoters and enhancers for FRY Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I032030 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.1 124 2 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS RUNX3 SP3 FRY FRY-AS1
GH13I031981 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -48.9 -48864 1.2 FOXA2 NFIB JUN ZNF644 YY1 POLR2A SCRT2 FOSL2 FOS CHD2 FRY FRY-AS1 N4BP2L1 LINC01073 ENSG00000278732
GH13I032142 Enhancer 1.1 Ensembl ENCODE 11.2 +111.7 111742 1.1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 ETS1 NFYC MXD4 PPARG FRY FRY-AS1 GC13P032060 GC13P032297
GH13I031908 Enhancer 0.8 Ensembl ENCODE 15 -121.9 -121927 1.7 SMARCA5 CTCF ZNF654 TRIM22 MAX JUNB CEBPB REST RAD21 ZNF592 FRY FRY-AS1 ENSG00000279314 LOC105370152 EEF1DP3
GH13I032124 Enhancer 1 FANTOM5 Ensembl ENCODE 11.2 +94.5 94454 2.1 POLR2A CEBPB RCOR1 CUX1 EP300 TCF7L2 FRY FRY-AS1 N4BP2L2 BRCA2 N4BP2L1 GC13P032060 GC13P032297
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FRY on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FRY gene promoter:

Genomic Locations for FRY Gene

Genomic Locations for FRY Gene
chr13:32,031,300-32,299,122
(GRCh38/hg38)
Size:
267,823 bases
Orientation:
Plus strand
chr13:32,605,437-32,870,794
(GRCh37/hg19)

Genomic View for FRY Gene

Genes around FRY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRY Gene

Proteins for FRY Gene

  • Protein details for FRY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TBA9-FRY_HUMAN
    Recommended name:
    Protein furry homolog
    Protein Accession:
    Q5TBA9
    Secondary Accessions:
    • Q9Y3N6

    Protein attributes for FRY Gene

    Size:
    3013 amino acids
    Molecular mass:
    338875 Da
    Quaternary structure:
    • When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA.
    SequenceCaution:
    • Sequence=CAB42442.1; Type=Frameshift; Positions=1340, 1378; Evidence={ECO:0000305};

neXtProt entry for FRY Gene

Post-translational modifications for FRY Gene

No data available for DME Specific Peptides for FRY Gene

Domains & Families for FRY Gene

Gene Families for FRY Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q5TBA9

UniProtKB/Swiss-Prot:

FRY_HUMAN :
  • Belongs to the furry protein family.
Family:
  • Belongs to the furry protein family.
genes like me logo Genes that share domains with FRY: view

Function for FRY Gene

Molecular function for FRY Gene

UniProtKB/Swiss-Prot Function:
Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.

Phenotypes From GWAS Catalog for FRY Gene

Gene Ontology (GO) - Molecular Function for FRY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
genes like me logo Genes that share ontologies with FRY: view
genes like me logo Genes that share phenotypes with FRY: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRY Gene

Localization for FRY Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRY Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRY gene
Compartment Confidence
plasma membrane 3
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FRY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005938 cell cortex IBA --
genes like me logo Genes that share ontologies with FRY: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FRY Gene

Pathways & Interactions for FRY Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0031175 neuron projection development IBA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:0090527 actin filament reorganization IBA --
GO:1904428 negative regulation of tubulin deacetylation IEA --
genes like me logo Genes that share ontologies with FRY: view

No data available for Pathways by source and SIGNOR curated interactions for FRY Gene

Drugs & Compounds for FRY Gene

No Compound Related Data Available

Transcripts for FRY Gene

Unigene Clusters for FRY Gene

Furry homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRY Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 51 ^ 52a · 52b · 52c ^ 53 ^ 54 ^ 55a · 55b ^ 56a · 56b · 56c ^ 57 ^ 58 ^ 59a · 59b ^ 60 ^ 61 ^ 62 ^ 63a · 63b
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for FRY Gene

GeneLoc Exon Structure for
FRY
ECgene alternative splicing isoforms for
FRY

Expression for FRY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FRY Gene

This gene is overexpressed in Nasal epithelium (53.2) and Bone (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FRY Gene



NURSA nuclear receptor signaling pathways regulating expression of FRY Gene:

FRY

SOURCE GeneReport for Unigene cluster for FRY Gene:

Hs.507669

Evidence on tissue expression from TISSUES for FRY Gene

  • Liver(4.1)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with FRY: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRY Gene

Orthologs for FRY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FRY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRY 33 34
  • 99.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
-- 34
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FRY 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRY 33 34
  • 92.14 (n)
cow
(Bos Taurus)
Mammalia FRY 33 34
  • 90.68 (n)
mouse
(Mus musculus)
Mammalia Fry 33 16 34
  • 87 (n)
rat
(Rattus norvegicus)
Mammalia Fry 33
  • 86.07 (n)
chicken
(Gallus gallus)
Aves FRY 33 34
  • 82.27 (n)
lizard
(Anolis carolinensis)
Reptilia FRY 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fry 33
  • 78.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8693 33
zebrafish
(Danio rerio)
Actinopterygii frya 34
  • 76 (a)
OneToMany
fryb 33 34
  • 71.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta fry 34
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sax-2 34
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAO3 34
  • 20 (a)
OneToMany
Species where no ortholog for FRY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRY Gene

ENSEMBL:
Gene Tree for FRY (if available)
TreeFam:
Gene Tree for FRY (if available)

Paralogs for FRY Gene

Paralogs for FRY Gene

(6) SIMAP similar genes for FRY Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FRY: view

Variants for FRY Gene

Sequence variations from dbSNP and Humsavar for FRY Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000013025 -- 32,106,741(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000041285 -- 32,205,042(+) A/C intron_variant
rs1000045945 -- 32,249,303(+) C/G intron_variant
rs1000089376 -- 32,217,155(+) G/A intron_variant
rs1000115154 -- 32,113,620(+) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FRY Gene

Variant ID Type Subtype PubMed ID
dgv946n106 CNV tandem duplication 24896259
esv2060908 CNV deletion 18987734
esv2672148 CNV deletion 23128226
esv3306941 CNV mobile element insertion 20981092
esv3309491 CNV mobile element insertion 20981092
esv3310190 CNV mobile element insertion 20981092
esv3373978 CNV insertion 20981092
esv3413949 CNV insertion 20981092
esv3421906 CNV insertion 20981092
esv3428476 CNV insertion 20981092
esv3580596 CNV loss 25503493
esv3580597 CNV loss 25503493
esv3631715 CNV loss 21293372
nsv1129167 CNV insertion 24896259
nsv1138210 CNV deletion 24896259
nsv1150098 CNV insertion 26484159
nsv472285 CNV novel sequence insertion 20440878
nsv519928 CNV loss 19592680
nsv561432 CNV loss 21841781
nsv818954 CNV loss 17921354
nsv952536 CNV duplication 24416366

Variation tolerance for FRY Gene

Residual Variation Intolerance Score: 0.126% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.12; 87.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FRY Gene

Human Gene Mutation Database (HGMD)
FRY
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRY Gene

Disorders for FRY Gene

Additional Disease Information for FRY

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FRY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRY Gene

Publications for FRY Gene

  1. Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. (PMID: 23886946) Nagai T … Mizuno K (Journal of cell science 2013) 2 3 58
  2. Furry protein promotes aurora A-mediated Polo-like kinase 1 activation. (PMID: 22753416) Ikeda M … Mizuno K (The Journal of biological chemistry 2012) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 58

Products for FRY Gene

Sources for FRY Gene

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