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Aliases for FRY Gene

Aliases for FRY Gene

  • FRY Microtubule Binding Protein 2 3 5
  • C13orf14 3 4
  • Chromosome 13 Open Reading Frame 14 2
  • Furry Homolog (Drosophila) 2
  • WUGSC:H_2G3A.1 3
  • Furry Homolog 3
  • BA207N4.2 3
  • BA37E23.1 3
  • 13CDNA73 3
  • 214K23.2 3
  • CG003 3

External Ids for FRY Gene

Previous HGNC Symbols for FRY Gene

  • C13orf14

Previous GeneCards Identifiers for FRY Gene

  • GC13P031504
  • GC13P032605
  • GC13P013416

Summaries for FRY Gene

GeneCards Summary for FRY Gene

FRY (FRY Microtubule Binding Protein) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is FRYL.

UniProtKB/Swiss-Prot for FRY Gene

  • Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRY Gene

Genomics for FRY Gene

Regulatory Elements for FRY Gene

Promoters for FRY Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FRY on UCSC Golden Path with GeneCards custom track

Genomic Location for FRY Gene

Chromosome:
13
Start:
32,031,300 bp from pter
End:
32,299,122 bp from pter
Size:
267,823 bases
Orientation:
Plus strand

Genomic View for FRY Gene

Genes around FRY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRY Gene

Proteins for FRY Gene

  • Protein details for FRY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TBA9-FRY_HUMAN
    Recommended name:
    Protein furry homolog
    Protein Accession:
    Q5TBA9
    Secondary Accessions:
    • Q9Y3N6

    Protein attributes for FRY Gene

    Size:
    3013 amino acids
    Molecular mass:
    338875 Da
    Quaternary structure:
    • When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA.
    SequenceCaution:
    • Sequence=CAB42442.1; Type=Frameshift; Positions=1340, 1378; Evidence={ECO:0000305};

neXtProt entry for FRY Gene

Proteomics data for FRY Gene at MOPED

Post-translational modifications for FRY Gene

Other Protein References for FRY Gene

No data available for DME Specific Peptides for FRY Gene

Domains & Families for FRY Gene

Protein Domains for FRY Gene

Graphical View of Domain Structure for InterPro Entry

Q5TBA9

UniProtKB/Swiss-Prot:

FRY_HUMAN :
  • Belongs to the furry protein family.
Family:
  • Belongs to the furry protein family.
genes like me logo Genes that share domains with FRY: view

No data available for Gene Families for FRY Gene

Function for FRY Gene

Molecular function for FRY Gene

UniProtKB/Swiss-Prot Function:
Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
genes like me logo Genes that share phenotypes with FRY: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRY Gene

Localization for FRY Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRY Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRY Gene COMPARTMENTS Subcellular localization image for FRY gene
Compartment Confidence
cytoskeleton 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FRY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
genes like me logo Genes that share ontologies with FRY: view

Pathways & Interactions for FRY Gene

SuperPathways for FRY Gene

No Data Available

Interacting Proteins for FRY Gene

Gene Ontology (GO) - Biological Process for FRY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:1904428 negative regulation of tubulin deacetylation IEA --
genes like me logo Genes that share ontologies with FRY: view

No data available for Pathways by source and SIGNOR curated interactions for FRY Gene

Drugs & Compounds for FRY Gene

No Compound Related Data Available

Transcripts for FRY Gene

Unigene Clusters for FRY Gene

Furry homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRY Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 51 ^ 52a · 52b · 52c ^ 53 ^ 54 ^ 55a · 55b ^ 56a · 56b · 56c ^ 57 ^ 58 ^ 59a · 59b ^ 60 ^ 61 ^ 62 ^ 63a · 63b
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for FRY Gene

GeneLoc Exon Structure for
FRY
ECgene alternative splicing isoforms for
FRY

Expression for FRY Gene

mRNA expression in normal human tissues for FRY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FRY Gene

This gene is overexpressed in Nasal epithelium (53.2) and Bone (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRY Gene



SOURCE GeneReport for Unigene cluster for FRY Gene Hs.507669

genes like me logo Genes that share expression patterns with FRY: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FRY Gene

Orthologs for FRY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FRY Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FRY 35
  • 90.68 (n)
  • 97.31 (a)
FRY 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRY 35
  • 92.14 (n)
  • 97.71 (a)
FRY 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fry 35
  • 87 (n)
  • 96.61 (a)
Fry 16
Fry 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FRY 35
  • 99.58 (n)
  • 99.93 (a)
FRY 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fry 35
  • 86.07 (n)
  • 95.58 (a)
oppossum
(Monodelphis domestica)
Mammalia FRY 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves FRY 35
  • 82.27 (n)
  • 93.75 (a)
FRY 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRY 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fry 35
  • 78.04 (n)
  • 88.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8693 35
zebrafish
(Danio rerio)
Actinopterygii fryb 35
  • 71.48 (n)
  • 78.95 (a)
frya 36
  • 76 (a)
OneToMany
fryb 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fry 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sax-2 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAO3 36
  • 20 (a)
OneToMany
Species with no ortholog for FRY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRY Gene

ENSEMBL:
Gene Tree for FRY (if available)
TreeFam:
Gene Tree for FRY (if available)

Paralogs for FRY Gene

Paralogs for FRY Gene

(6) SIMAP similar genes for FRY Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FRY: view

Variants for FRY Gene

Sequence variations from dbSNP and Humsavar for FRY Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2806639 - 32,237,470(+) CCAGC(A/G)GCAAC reference, missense
rs908 -- 32,278,731(-) CCCCA(A/C)AAATC intron-variant
rs114827 -- 32,285,286(+) ATGGC(C/G)CCCCA intron-variant
rs120650 -- 32,063,688(+) CCAGA(A/G)TCTGC intron-variant
rs395341 -- 32,156,091(-) CACAA(A/T)ATAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRY Gene

Variant ID Type Subtype PubMed ID
nsv818954 CNV Loss 17921354
esv2060908 CNV Deletion 18987734
esv274462 CNV Insertion 20981092
esv2672148 CNV Deletion 23128226
nsv519928 CNV Loss 19592680
esv273763 CNV Insertion 20981092
esv271217 CNV Insertion 20981092

Variation tolerance for FRY Gene

Residual Variation Intolerance Score: 0.126% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.12; 87.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRY Gene

HapMap Linkage Disequilibrium report
FRY
Human Gene Mutation Database (HGMD)
FRY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRY Gene

Disorders for FRY Gene

Relevant External Links for FRY

Genetic Association Database (GAD)
FRY
Human Genome Epidemiology (HuGE) Navigator
FRY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRY

No disorders were found for FRY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRY Gene

Publications for FRY Gene

  1. Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. (PMID: 23886946) Nagai T. … Mizuno K. (J. Cell. Sci. 2013) 2 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  3. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PMID: 8812419) Couch F.J. … Simard J. (Genomics 1996) 2 3
  4. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3
  5. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. (PMID: 24880342) Wang Y. … Amos C.I. (Nat. Genet. 2014) 3

Products for FRY Gene

Sources for FRY Gene

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