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FRY Gene

protein-coding   GIFtS: 52
GCID: GC13P032605

Furry Homolog (Drosophila)

(Previous name: chromosome 13 open reading frame 14)
(Previous symbol: C13orf14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Furry Homolog (Drosophila)1 2     CG0032
C13orf141 2 3 5     WUGSC:H_2G3A.12
Chromosome 13 Open Reading Frame 141     bA207N4.22
13CDNA732     bA37E23.12
214K23.22     Protein Furry Homolog2

External Ids:    HGNC: 203671   Entrez Gene: 101292   Ensembl: ENSG000000739107   OMIM: 6148185   UniProtKB: Q5TBA93   

Export aliases for FRY gene to outside databases

Previous GC identifers: GC13P031504 GC13P013416


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FRY Gene:
FRY (furry homolog (Drosophila)) is a protein-coding gene. An important paralog of this gene is FRYL.

UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9
Function: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of
spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold
promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRY gene promoter:
         FOXO3   Nkx5-1   RORalpha2   GATA-1   Evi-1   FOXO3b   AREB6   FOXJ2 (long isoform)   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRY promoter sequence
   Search Chromatin IP Primers for FRY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1   Ensembl cytogenetic band:  13q13.1   HGNC cytogenetic band: 13q13.1

FRY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRY gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P032605:  view genomic region     (about GC identifiers)

Start:
32,605,437 bp from pter      End:
32,870,794 bp from pter
Size:
265,358 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9 (See protein sequence)
Recommended Name: Protein furry homolog  
Size: 3013 amino acids; 338875 Da
Subunit: When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in
interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA
Sequence caution: Sequence=CAB42442.1; Type=Frameshift; Positions=1340, 1378;
Secondary accessions: Q9Y3N6

Explore the universe of human proteins at neXtProt for FRY: NX_Q5TBA9

Explore proteomics data for FRY at MOPED

Post-translational modifications: 

  • Phosphorylated by AURKA, CDK1 and PLK11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FRY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075463.2  
    ENSEMBL proteins: 
     ENSP00000369600   ENSP00000398010   ENSP00000434694   ENSP00000369565   ENSP00000445043  

    FRY Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FRY

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR025614 Cell_morpho_N
     IPR025481 Cell_Morphogen_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q5TBA9

    ProtoNet protein and cluster: Q5TBA9

    1 Blocks protein domain: IPB006203 GHMP kinase

    UniProtKB/Swiss-Prot: FRY_HUMAN, Q5TBA9
    Similarity: Belongs to the furry protein family


    Find genes that share domains with FRY           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRY_HUMAN, Q5TBA9
    Function: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of
    spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold
    promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    Find genes that share ontologies with FRY           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FRY

    miRNA
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    miRTarBase miRNAs that target FRY:
    hsa-mir-132-3p (MIRT021767)

    Block miRNA regulation of human, mouse, rat FRY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRY (see all 21):
    hsa-miR-137 hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-628-3p hsa-miR-424 hsa-miR-9 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidFRY 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FRY_HUMAN, Q5TBA9: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
    cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the
    separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase,
    to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with
    PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages
    of the cell cycle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane3
    cytosol2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--

    Find genes that share ontologies with FRY           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FRY
    Interactions:

        Search GeneGlobe Interaction Network for FRY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FRY (Q5TBA92, 3 ENSP000003696004) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50897 I2D: score=1 STRING: ENSP00000306330
    SIAH1Q8IUQ43, ENSP000003491564I2D: score=1 STRING: ENSP00000349156
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AKT3Q9Y2433I2D: score=4 
    ARHGAP1Q079603I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FRY



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FRY gene: 
    NM_023037.2  

    Unigene Cluster for FRY:

    Furry homolog (Drosophila)
    Hs.507669  [show with all ESTs]
    Unigene Representative Sequence: NM_023037
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380250(uc001utx.3 uc010tdw.2 uc001utz.3 uc010tdx.2)
    ENST00000463566 ENST00000436046 ENST00000602645 ENST00000477712 ENST00000380217
    ENST00000542859
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FRY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRY (see all 21):
    hsa-miR-137 hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-628-3p hsa-miR-424 hsa-miR-9 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidFRY 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FRY
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FRY (NM_023037)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRY
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FRY
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FRY
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRY
      QuantiTect SYBR Green Assays in human, mouse, rat FRY
      QuantiFast Probe-based Assays in human, mouse, rat FRY

    Additional mRNA sequence: 

    AK091422.1 AK298021.1 AL049784.1 BX648226.1 U50526.1 U50534.1 U57961.1 

    13 DOTS entries:

    DT.455706  DT.100022238  DT.100810409  DT.70104802  DT.101974982  DT.91739417  DT.91694870  DT.97840666 
    DT.421693  DT.91739396  DT.95164829  DT.99968845  DT.454125 

    Selected AceView cDNA sequences (see all 134):

    D79325 BX441369 BQ015530 AI801267 BX641976 BI766462 BE615040 BE614799 
    BX494316 CA952510 BM677315 NM_023037 BU733162 AK091422 BM707606 BM721728 
    CB528947 CR621863 AI221603 BE531155 BI493200 AA740292 AA804739 AL049784 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FRY (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:              -                                                                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 51 ^ 52a · 52b · 52c ^ 53 ^ 54 ^ 55a · 55b ^ 56a · 56b · 56c ^ 57 ^ 58 ^ 59a · 59b ^ 60 ^ 61 ^ 62 ^ 63a · 63b
    SP1:        -     -                             -                                         -     -                           
    SP2:                                                                                                                        
    SP3:                                            -                                                                           
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for FRY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FRY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACTTGTT
    FRY Expression
    About this image


    FRY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    FRY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRY Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507669
        Custom PCR Arrays for FRY
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FRY gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fry1 , 5 furry homolog (Drosophila)1, 5 87(n)1
    96.61(a)1
      5 (89.36 cM)5
    3203651  NM_172887.21  NP_766475.21 
     1502599305 
    chicken
    (Gallus gallus)
    Aves FRY1 furry homolog (Drosophila) 82.27(n)
    93.75(a)
      418915  XM_003640579.2  XP_003640627.1 
    lizard
    (Anolis carolinensis)
    Reptilia FRY6
    furry homolog (Drosophila)
    92(a)
    1 ↔ 1
    3(183765981-183960420)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.86932 Xenopus laevis transcribed sequence with moderate similarity more 79.46(n)    BJ070503.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fryb1 furry homolog b (Drosophila) 71.48(n)
    78.95(a)
      792949  XM_001332213.5  XP_001332249.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta fry6
    furry
    34(a)
    1 ↔ 1
    3L(9624934-9672203)
    worm
    (Caenorhabditis elegans)
    Secernentea sax-26
    Protein SAX-2, isoform a
    30(a)
    1 ↔ 1
    III(5109701-5130675) WBGene00004728
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAO36
    Component of the RAM signaling network that is inv...
    20(a)
    1 → many
    IX(106107-113237) YIL129C


    ENSEMBL Gene Tree for FRY (if available)
    TreeFam Gene Tree for FRY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FRY gene
    FRYL2  
    5 SIMAP similar genes for FRY using alignment to 6 protein entries:     FRY_HUMAN (see all proteins):
    DKFZp686K08123    214K23.2    FRYL    DKFZp781A0295    WUGSC

    Find genes that share paralogs with FRY           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FRY (see all 5438)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665582301,2
    C--13680597(+) AAAAA-/AAA   
       
    /AAAA
    CAGAT
    2 -- int1 cds11NA 2
    rs1864739251,2
    --32608143(+) ACCTTA/GGCTGA 1 -- int10--------
    rs1910109921,2
    --32608355(+) TTTTGC/TAAGGT 1 -- int10--------
    rs2041261,2
    C,F,O,A,H--32608479(+) TCACAG/AGCCAA 1 -- int135Minor allele frequency- A:0.40NS NA EA WA CSA 3196
    rs1827658441,2
    --32608480(+) CACAGA/GCCAAT 1 -- int10--------
    rs1877882401,2
    --32608498(+) TCAGTC/TGCTGG 1 -- int10--------
    rs1403189301,2
    --32608514(+) GAGATA/GTACTA 1 -- int10--------
    rs1450555881,2
    --32608530(+) CATTCA/GATGTT 1 -- int10--------
    rs757582221,2
    --32608547(+) GGTGTA/TCTCCT 1 -- int10--------
    rs1404531831,2
    --32608707(+) TCCCTG/TCTCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FRY (32605437 - 32855437 bp, first 250kb of FRY)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FRY:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2060908CNV Deletion18987734
    esv2672148CNV Deletion23128226
    esv271217CNV Insertion20981092
    esv273763CNV Insertion20981092
    esv274462CNV Insertion20981092
    nsv519928CNV Loss19592680
    nsv818954CNV Loss17921354

    Human Gene Mutation Database (HGMD): FRY
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FRY
    DNA2.0 Custom Variant and Variant Library Synthesis for FRY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614818    OMIM disorders: --


    Find genes that share disorders with FRY           About GenesLikeMe

    Genetic Association Database (GAD): FRY
    Human Genome Epidemiology (HuGE) Navigator: FRY (15 documents)

    Export disorders for FRY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FRY gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with FRY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Furry protein promotes Aurora A-mediated polo-like kinase 1 activation. (PubMed id 22753416)1, 2 Ikeda M.... Mizuno K. (J. Biol. Chem. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)1, 3 Couch F.J.... Simard J. (Genomics 1996)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes. (PubMed id 19327996)1 Chiba S....Mizuno K. (Curr. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10129 HGNC: 20367 AceView: 13CDNA73 Ensembl:ENSG00000073910 euGenes: HUgn10129
    ECgene: FRY H-InvDB: FRY

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FRY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FRY gene:
    Search GeneIP for patents involving FRY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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