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Aliases for FRS3 Gene

Aliases for FRS3 Gene

  • Fibroblast Growth Factor Receptor Substrate 3 2 3
  • FGFR-Signaling Adaptor SNT2 3 4
  • FGFR Substrate 3 3 4
  • SNT-2 3 4
  • Suc1-Associated Neurotrophic Factor Target 2 (FGFR Signalling Adaptor) 3
  • Suc1-Associated Neurotrophic Factor Target 2 4
  • FRS2-Beta 3
  • FRS2beta 3
  • FRS2B 3
  • SNT2 3

External Ids for FRS3 Gene

Summaries for FRS3 Gene

Entrez Gene Summary for FRS3 Gene

  • This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

GeneCards Summary for FRS3 Gene

FRS3 (Fibroblast Growth Factor Receptor Substrate 3) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include insulin receptor binding and fibroblast growth factor receptor binding.

UniProtKB/Swiss-Prot for FRS3 Gene

  • Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Gene Wiki entry for FRS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRS3 Gene

Genomics for FRS3 Gene

Genomic Location for FRS3 Gene

Start:
41,770,021 bp from pter
End:
41,786,542 bp from pter
Size:
16,522 bases
Orientation:
Minus strand

Genomic View for FRS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRS3 Gene

Regulatory Elements for FRS3 Gene

Proteins for FRS3 Gene

  • Protein details for FRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43559-FRS3_HUMAN
    Recommended name:
    Fibroblast growth factor receptor substrate 3
    Protein Accession:
    O43559
    Secondary Accessions:
    • Q5T3D5

    Protein attributes for FRS3 Gene

    Size:
    492 amino acids
    Molecular mass:
    54462 Da
    Quaternary structure:
    • Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.
    SequenceCaution:
    • Sequence=CAI13184.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FRS3 Gene

neXtProt entry for FRS3 Gene

Proteomics data for FRS3 Gene at MOPED

Post-translational modifications for FRS3 Gene

  • Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FRS3 Gene

Domains for FRS3 Gene

Protein Domains for FRS3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FRS3_HUMAN
Domain:
  • Contains 1 IRS-type PTB domain.:
    • O43559
genes like me logo Genes that share domains with FRS3: view

No data available for Gene Families for FRS3 Gene

Function for FRS3 Gene

Molecular function for FRS3 Gene

UniProtKB/Swiss-Prot Function: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Gene Ontology (GO) - Molecular Function for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IPI 9660748
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with FRS3: view

miRNA for FRS3 Gene

miRTarBase miRNAs that target FRS3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FRS3 Gene

Localization for FRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRS3 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRS3 Gene COMPARTMENTS Subcellular localization image for FRS3 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with FRS3: view

Pathways for FRS3 Gene

genes like me logo Genes that share pathways with FRS3: view

Gene Ontology (GO) - Biological Process for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8761293
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FRS3: view

Compounds for FRS3 Gene

(1) Novoseek inferred chemical compound relationships for FRS3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 52.9 8
genes like me logo Genes that share compounds with FRS3: view

Transcripts for FRS3 Gene

Unigene Clusters for FRS3 Gene

Fibroblast growth factor receptor substrate 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRS3 Gene

No ASD Table

Relevant External Links for FRS3 Gene

GeneLoc Exon Structure for
FRS3
ECgene alternative splicing isoforms for
FRS3

Expression for FRS3 Gene

mRNA expression in normal human tissues for FRS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for FRS3 Gene Hs.194208

genes like me logo Genes that share expressions with FRS3: view

Orthologs for FRS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRS3 36
  • 99.19 (n)
  • 99.59 (a)
FRS3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRS3 36
  • 89.63 (n)
  • 94.31 (a)
FRS3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRS3 36
  • 90.72 (n)
  • 94.31 (a)
FRS3 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frs3 36
  • 84.7 (n)
  • 86.68 (a)
Frs3 16
Frs3 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRS3 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRS3 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frs3 36
  • 86 (n)
  • 88.73 (a)
chicken
(Gallus gallus)
Aves FRS3 36
  • 69.32 (n)
  • 65.06 (a)
FRS3 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRS3 37
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frs3 36
  • 65.06 (n)
  • 64.92 (a)
zebrafish
(Danio rerio)
Actinopterygii FRS3 37
  • 41 (a)
OneToOne
LOC100330147 36
  • 62.16 (n)
  • 59.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13398 37
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rog-1 37
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 22 (a)
OneToMany
Species with no ortholog for FRS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRS3 Gene

ENSEMBL:
Gene Tree for FRS3 (if available)
TreeFam:
Gene Tree for FRS3 (if available)

Paralogs for FRS3 Gene

Selected SIMAP similar genes for FRS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FRS3: view

No data available for Paralogs for FRS3 Gene

Variants for FRS3 Gene

Sequence variations from dbSNP and Humsavar for FRS3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1057227 -- 41,770,420(-) CTGGG(A/G)AGAGA utr-variant-3-prime, synonymous-codon, reference
rs2275748 -- 41,772,680(-) AGCCA(A/G)CCTTC intron-variant
rs3747747 - 41,771,436(-) CCTCC(C/T)GCAGG reference, missense
rs3761781 -- 41,777,210(-) TAACA(C/T)ATTGT intron-variant
rs3804281 -- 41,778,251(-) ACTGT(C/T)AGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRS3 Gene

Variant ID Type Subtype PubMed ID
nsv885833 CNV Loss 21882294

Relevant External Links for FRS3 Gene

HapMap Linkage Disequilibrium report
FRS3

Disorders for FRS3 Gene

(1) Novoseek inferred disease relationships for FRS3 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for FRS3

Genetic Association Database (GAD)
FRS3
Human Genome Epidemiology (HuGE) Navigator
FRS3
genes like me logo Genes that share disorders with FRS3: view

No data available for UniProtKB/Swiss-Prot for FRS3 Gene

Publications for FRS3 Gene

  1. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. (PMID: 15485655) Huang L. … Tsuchida N. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. (PMID: 9660748) Xu H. … Goldfarb M.P. (J. Biol. Chem. 1998) 2 3 4
  3. Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. (PMID: 16702953) Huang L. … Tsuchida N. (Oncogene 2006) 3 23
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. (PMID: 15094036) Gotoh N. … Schlessinger J. (FEBS Lett. 2004) 3 4

Products for FRS3 Gene

Sources for FRS3 Gene

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