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FRS3 Gene

protein-coding   GIFtS: 54
GCID: GC06M041737

Fibroblast Growth Factor Receptor Substrate 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Growth Factor Receptor Substrate 31 2     FRS2B2
SNT-22 3     FRS2beta2
FGFR Substrate 32 3     SNT22
FGFR-Signaling Adaptor SNT22 3     Suc1-Associated Neurotrophic Factor Target 2 (FGFR Signalling Adaptor)2
FRS2-beta2     Suc1-Associated Neurotrophic Factor Target 23

External Ids:    HGNC: 169701   Entrez Gene: 108172   Ensembl: ENSG000001372187   OMIM: 6077445   UniProtKB: O435593   

Export aliases for FRS3 gene to outside databases

Previous GC identifers: GC06M041740 GC06M041784 GC06M041845 GC06M041456


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FRS3 Gene:
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the
peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The
encoded protein down-regulates extracellular regulated kinase 2 through direct binding. (provided by RefSeq, Jul
2013)

GeneCards Summary for FRS3 Gene:
FRS3 (fibroblast growth factor receptor substrate 3) is a protein-coding gene. GO annotations related to this gene include fibroblast growth factor receptor binding and insulin receptor binding. An important paralog of this gene is FRS2.

UniProtKB/Swiss-Prot: FRS3_HUMAN, O43559
Function: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the
activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear
translocation of ERK2

Gene Wiki entry for FRS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRS3 gene promoter:
         E2F-3a   E2F-4   E2F-5   C/EBPbeta   Lmo2   E2F-2   Evi-1   MZF-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRS3 promoter sequence
   Search Chromatin IP Primers for FRS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

FRS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRS3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041737:  view genomic region     (about GC identifiers)

Start:
41,737,914 bp from pter      End:
41,754,280 bp from pter
Size:
16,367 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FRS3_HUMAN, O43559 (See protein sequence)
Recommended Name: Fibroblast growth factor receptor substrate 3  
Size: 492 amino acids; 54462 Da
Subunit: Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2
Sequence caution: Sequence=CAI13184.2; Type=Erroneous gene model prediction;
4 PDB 3D structures from and Proteopedia for FRS3:
2KUP (3D)        2KUQ (3D)        2YS5 (3D)        2YT2 (3D)    
Secondary accessions: Q5T3D5

Explore the universe of human proteins at neXtProt for FRS3: NX_O43559

Explore proteomics data for FRS3 at MOPED

Post-translational modifications: 

  • Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by BFGF or
    NGFB1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FRS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006644.1  
    ENSEMBL proteins: 
     ENSP00000362109   ENSP00000396715   ENSP00000413214   ENSP00000259748  
    Reactome Protein details: O43559

    FRS3 Human Recombinant Protein Products:

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    Novus Biologicals FRS3 Protein
    Novus Biologicals FRS3 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FRS3

     
    Search eBioscience for Proteins for FRS3 

     
    antibodies-online proteins for FRS3 (2 products) 

     
    antibodies-online peptides for FRS3

    FRS3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FRS3
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    antibodies-online antibodies for FRS3 (31 products) 

    FRS3 Assay Products:

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    Cloud-Clone Corp. ELISAs for FRS3
    Cloud-Clone Corp. CLIAs for FRS3
    Search eBioscience for ELISAs for FRS3 
    antibodies-online kits for FRS3 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O43559

    ProtoNet protein and cluster: O43559

    UniProtKB/Swiss-Prot: FRS3_HUMAN, O43559
    Similarity: Contains 1 IRS-type PTB domain


    Find genes that share domains with FRS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRS3_HUMAN, O43559
    Function: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the
    activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear
    translocation of ERK2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005104fibroblast growth factor receptor binding IPI9660748
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI18985028
         
    Find genes that share ontologies with FRS3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FRS3

    miRNA
    Products:
        
    miRTarBase miRNAs that target FRS3:
    hsa-mir-26b-5p (MIRT030227)

    Block miRNA regulation of human, mouse, rat FRS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRS3 (see all 14):
    hsa-miR-3163 hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-944 hsa-miR-551b* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidFRS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FRS3
    Predesigned siRNA for gene silencing in human, mouse, rat FRS3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FRS3 (NM_006653)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRS3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FRS3_HUMAN, O43559: Membrane; Lipid-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with FRS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FRS3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by FGFR0.91
    Downstream signaling of activated FGFR0.91
    Signaling by FGFR in disease0.91
    2FGFR ligand binding and activation
    FRS2-mediated cascade0.70
    3Signaling by GPCR
    Signal Transduction0.58
    4Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling
    5Disease
    Disease


    Find genes that share SuperPaths with FRS3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FRS3
        NGF Pathway
    TRKA Signaling

    2 BioSystems Pathways for FRS3
        BDNF signaling pathway
    Neurotrophic factor-mediated Trk receptor signaling

    1 Reactome Pathway for FRS3
        FRS2-mediated cascade


        Pathway & Disease-focused RT2 Profiler PCR Arrays including FRS3: 
              Insulin Signaling Pathway in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FRS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for FRS3 (O435592, 3 ENSP000002597484) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-8035512 MINT-8026161 I2D: score=2 STRING: ENSP00000340944
    KARSQ150462, 3, ENSP000003254484MINT-65540 I2D: score=4 STRING: ENSP00000325448
    MAPK1P284823, ENSP000002158324I2D: score=1 STRING: ENSP00000215832
    RND1Q927303, ENSP000003084614I2D: score=1 STRING: ENSP00000308461
    FGFR1P113623, ENSP000003802804I2D: score=3 STRING: ENSP00000380280
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8761293
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with FRS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FRS3

    1 Novoseek inferred chemical compound relationship for FRS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 52.9 9 16697063 (2), 16702953 (2), 15738000 (1), 15485655 (1) (see all 6)



    Find genes that share compounds with FRS3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FRS3 gene: 
    NM_006653.4  

    Unigene Cluster for FRS3:

    Fibroblast growth factor receptor substrate 3
    Hs.194208  [show with all ESTs]
    Unigene Representative Sequence: NM_006653
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373018(uc003orc.1) ENST00000426290 ENST00000422888 ENST00000466420
    ENST00000259748
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FRS3 (see all 14):
    hsa-miR-3163 hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-944 hsa-miR-551b* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidFRS3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FRS3
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    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FRS3
    OriGene qSTAR qPCR primer pairs in human, mouse for FRS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRS3
      QuantiTect SYBR Green Assays in human, mouse, rat FRS3
      QuantiFast Probe-based Assays in human, mouse, rat FRS3

    Additional mRNA sequence: 

    AF036718.1 BC010611.1 CR457026.1 

    2 DOTS entries:

    DT.202700  DT.92388410 

    Selected AceView cDNA sequences (see all 52):

    BM741226 BX098956 BM764849 BC010611 CD557174 BM766335 BM756817 BM757060 
    NM_006653 CR598942 BM771050 BF512369 BQ773527 CB960314 BM680142 AI879970 
    BM724909 BX390152 BM741175 BM922247 AF036718 BI757794 AI216717 AW957161 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FRS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGTGGGAC
    FRS3 Expression
    About this image


    FRS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    FRS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194208
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FRS3: 
              Insulin Signaling Pathway in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FRS3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frs31 , 5 fibroblast growth factor receptor substrate 31, 5 84.7(n)1
    86.68(a)1
      17 (23.88 cM)5
    1079711  NM_144939.21  NP_659188.11 
     476890305 
    chicken
    (Gallus gallus)
    Aves FRS31 fibroblast growth factor receptor substrate 3 69.32(n)
    65.06(a)
      419923  XM_418044.4  XP_418044.4 
    lizard
    (Anolis carolinensis)
    Reptilia FRS36
    fibroblast growth factor receptor substrate 3
    62(a)
    1 ↔ 1
    4(119482423-119504888)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia frs31 fibroblast growth factor receptor substrate 3 65.06(n)
    64.92(a)
      100101737  NM_001113669.1  NP_001107141.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003301471 fibroblast growth factor receptor substrate 2-like 62.16(n)
    59.41(a)
      100330147  XM_002662499.3  XP_002662545.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133986
    --
    17(a)
    1 → many
    2L(8412144-8415256)
    worm
    (Caenorhabditis elegans)
    Secernentea rog-16
    Protein ROG-1, isoform b (rog-1) mRNA, complete cd...
    12(a)
    1 → many
    II(1369046-1374985) WBGene00018819


    ENSEMBL Gene Tree for FRS3 (if available)
    TreeFam Gene Tree for FRS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FRS3 gene
    FRS22  
    1 SIMAP similar gene for FRS3 using alignment to 2 protein entries:     FRS3_HUMAN (see all proteins):
    FRS2

    Find genes that share paralogs with FRS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FRS3 (see all 272)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452068161,2
    --41737447(+) GTTCAC/TGACCA 1 -- ds50010--------
    rs1835107131,2
    --41737470(+) GGAGAA/CAAATA 1 -- ds50010--------
    rs47145121,2
    C,A--41737562(+) GAGTTC/TGAGAC 1 -- ds50018Minor allele frequency- T:0.00NA WA CSA 14
    rs1413799151,2
    --41737656(+) GCTACC/TTGGGA 1 -- ds50010--------
    rs1894157901,2
    --41737962(+) ACATTG/TAAAAC 1 -- ut310--------
    rs1433936871,2
    C--41738123(+) TTGACA/GTCTCG 1 -- ut310--------
    rs10572271,2
    C,F,H--41738158(-) CTGGGG/AAGAGA 1 -- ut31 trp318Minor allele frequency- A:0.13EA MN NS NA WA 4010
    rs1923184001,2
    --41738159(+) CTCTCC/TCCAGC 1 -- ut310--------
    rs759345251,2
    C--41738230(+) AAGCA-/TCTGGT 1 -- ut310--------
    rs454934991,2
    C--41738247(+) TCCATG/TCCTTC 1 -- ut312Minor allele frequency- T:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for FRS3 (41737914 - 41754280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FRS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885833CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FRS3
    DNA2.0 Custom Variant and Variant Library Synthesis for FRS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607744    OMIM disorders: --


    Find genes that share disorders with FRS3           About GenesLikeMe

    1 Novoseek inferred disease relationship for FRS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 2 16702953 (1)

    Genetic Association Database (GAD): FRS3
    Human Genome Epidemiology (HuGE) Navigator: FRS3 (2 documents)

    Export disorders for FRS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FRS3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with FRS3)
        Utopia: connect your pdf to the dynamic
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    1. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. (PubMed id 9660748)1, 2, 3 Xu H.... Goldfarb M.P. (J. Biol. Chem. 1998)
    2. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. (PubMed id 15485655)1, 2, 9 Huang L.... Tsuchida N. (Biochem. Biophys. Res. Commun. 2004)
    3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. (PubMed id 15094036)1, 2 Gotoh N.... Schlessinger J. (FEBS Lett. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras. (PubMed id 8761293)1, 3 Wang J.K....Goldfarb M. (Oncogene 1996)
    8. Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. (PubMed id 16702953)1, 9 Huang L....Tsuchida N. (Oncogene 2006)
    9. Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. (PubMed id 15738000)1, 9 Harada A....Negishi M. (J. Biol. Chem. 2005)
    10. The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins. (PubMed id 12586769)1, 9 Ranzi V....Greco A. (Endocrinology 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10817 HGNC: 16970 AceView: FRS3 Ensembl:ENSG00000137218 euGenes: HUgn10817
    ECgene: FRS3 H-InvDB: FRS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FRS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FRS3 gene:
    Search GeneIP for patents involving FRS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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