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Aliases for FRS3 Gene

Aliases for FRS3 Gene

  • Fibroblast Growth Factor Receptor Substrate 3 2 3 5
  • FGFR-Signaling Adaptor SNT2 3 4
  • FGFR Substrate 3 3 4
  • SNT-2 3 4
  • Suc1-Associated Neurotrophic Factor Target 2 (FGFR Signalling Adaptor) 3
  • Suc1-Associated Neurotrophic Factor Target 2 4
  • Testicular Tissue Protein Li 71 3
  • FRS2-Beta 3
  • FRS2beta 3
  • FRS2B 3
  • SNT2 3

External Ids for FRS3 Gene

Previous GeneCards Identifiers for FRS3 Gene

  • GC06M041740
  • GC06M041784
  • GC06M041845
  • GC06M041737
  • GC06M041456

Summaries for FRS3 Gene

Entrez Gene Summary for FRS3 Gene

  • This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

GeneCards Summary for FRS3 Gene

FRS3 (Fibroblast Growth Factor Receptor Substrate 3) is a Protein Coding gene. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include insulin receptor binding and fibroblast growth factor receptor binding. An important paralog of this gene is FRS2.

UniProtKB/Swiss-Prot for FRS3 Gene

  • Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Gene Wiki entry for FRS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRS3 Gene

Genomics for FRS3 Gene

Regulatory Elements for FRS3 Gene

Enhancers for FRS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F041934 1.5 FANTOM5 ENCODE 21.2 -152.2 -152164 8.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 PRICKLE4 USP49 FRS3 MED20 UBR2 ENSG00000207371 BYSL RNU6-761P TOMM6 ENSG00000206977
GH06F041784 1.2 ENCODE 23 +0.3 324 4.2 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A ZNF2 YY1 SLC30A9 PRICKLE4 MED20 FRS3 USP49 BYSL ENSG00000207371 PGC
GH06F042038 1.8 FANTOM5 Ensembl ENCODE 11.3 -258.4 -258397 13.7 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D PRICKLE4 TREML2 RNU6-761P ENSG00000207371 MED20 BYSL FRS3 CCND3 USP49 RRP36
GH06F042020 1.7 FANTOM5 Ensembl ENCODE 11.4 -240.5 -240455 12.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A ZNF143 FOS KLF13 ZNF263 PRICKLE4 MED20 CCND3 TAF8 TREML2 USP49 FRS3 C6orf226 ENSG00000207371 BYSL
GH06F041919 1.4 FANTOM5 ENCODE 10.3 -135.0 -134968 4.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 KLF13 MED20 FRS3 PRICKLE4 LOC105375060
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FRS3 on UCSC Golden Path with GeneCards custom track

Promoters for FRS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001216645 -1058 2801 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A ZNF2 YY1

Genomic Location for FRS3 Gene

Chromosome:
6
Start:
41,770,176 bp from pter
End:
41,786,542 bp from pter
Size:
16,367 bases
Orientation:
Minus strand

Genomic View for FRS3 Gene

Genes around FRS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRS3 Gene

Proteins for FRS3 Gene

  • Protein details for FRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43559-FRS3_HUMAN
    Recommended name:
    Fibroblast growth factor receptor substrate 3
    Protein Accession:
    O43559
    Secondary Accessions:
    • Q5T3D5

    Protein attributes for FRS3 Gene

    Size:
    492 amino acids
    Molecular mass:
    54462 Da
    Quaternary structure:
    • Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.
    SequenceCaution:
    • Sequence=CAI13184.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FRS3 Gene

neXtProt entry for FRS3 Gene

Post-translational modifications for FRS3 Gene

  • Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRS3 Gene

No data available for DME Specific Peptides for FRS3 Gene

Domains & Families for FRS3 Gene

Protein Domains for FRS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43559

UniProtKB/Swiss-Prot:

FRS3_HUMAN :
  • Contains 1 IRS-type PTB domain.
Domain:
  • Contains 1 IRS-type PTB domain.
genes like me logo Genes that share domains with FRS3: view

No data available for Gene Families for FRS3 Gene

Function for FRS3 Gene

Molecular function for FRS3 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Gene Ontology (GO) - Molecular Function for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IPI 9660748
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 18985028
GO:0042802 identical protein binding IPI 25814554
genes like me logo Genes that share ontologies with FRS3: view
genes like me logo Genes that share phenotypes with FRS3: view

Animal Model Products

miRNA for FRS3 Gene

miRTarBase miRNAs that target FRS3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRS3 Gene

Localization for FRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRS3 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRS3 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FRS3: view

Pathways & Interactions for FRS3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Negative regulation of FGFR1 signaling
4 NGF Pathway
5 Developmental Biology
genes like me logo Genes that share pathways with FRS3: view

Pathways by source for FRS3 Gene

Gene Ontology (GO) - Biological Process for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction TAS 8761293
GO:0008543 fibroblast growth factor receptor signaling pathway IGI,TAS 9660748
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with FRS3: view

No data available for SIGNOR curated interactions for FRS3 Gene

Drugs & Compounds for FRS3 Gene

(1) Drugs for FRS3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FRS3: view

Transcripts for FRS3 Gene

Unigene Clusters for FRS3 Gene

Fibroblast growth factor receptor substrate 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRS3 Gene

No ASD Table

Relevant External Links for FRS3 Gene

GeneLoc Exon Structure for
FRS3
ECgene alternative splicing isoforms for
FRS3

Expression for FRS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FRS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FRS3 Gene:

FRS3

SOURCE GeneReport for Unigene cluster for FRS3 Gene:

Hs.194208
genes like me logo Genes that share expression patterns with FRS3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FRS3 Gene

Orthologs for FRS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRS3 34 35
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia FRS3 34 35
  • 90.72 (n)
cow
(Bos Taurus)
Mammalia FRS3 34 35
  • 89.63 (n)
rat
(Rattus norvegicus)
Mammalia Frs3 34
  • 86 (n)
mouse
(Mus musculus)
Mammalia Frs3 34 16 35
  • 84.7 (n)
oppossum
(Monodelphis domestica)
Mammalia FRS3 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRS3 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FRS3 34 35
  • 69.32 (n)
lizard
(Anolis carolinensis)
Reptilia FRS3 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frs3 34
  • 65.06 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330147 34
  • 62.16 (n)
FRS3 35
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13398 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rog-1 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for FRS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRS3 Gene

ENSEMBL:
Gene Tree for FRS3 (if available)
TreeFam:
Gene Tree for FRS3 (if available)

Paralogs for FRS3 Gene

Paralogs for FRS3 Gene

(1) SIMAP similar genes for FRS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FRS3: view

Variants for FRS3 Gene

Sequence variations from dbSNP and Humsavar for FRS3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1057227 -- 41,770,420(-) CTGGG(A/G)AGAGA utr-variant-3-prime
rs10947986 -- 41,780,541(+) AGGCC(A/G)TGGAG upstream-variant-2KB
rs111283076 -- 41,772,763(+) GTGTG(A/T)GTGTG intron-variant
rs111464322 -- 41,770,948(+) GCTGC(C/T)GTGGC reference, missense
rs111924275 -- 41,775,955(+) AAGGG(G/T)TTCAA intron-variant

Variation tolerance for FRS3 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FRS3 Gene

Disorders for FRS3 Gene

Relevant External Links for FRS3

Genetic Association Database (GAD)
FRS3
Human Genome Epidemiology (HuGE) Navigator
FRS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRS3

No disorders were found for FRS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRS3 Gene

Publications for FRS3 Gene

  1. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. (PMID: 15485655) Huang L. … Tsuchida N. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  2. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. (PMID: 9660748) Xu H. … Goldfarb M.P. (J. Biol. Chem. 1998) 2 3 4 64
  3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64
  4. Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. (PMID: 16702953) Huang L. … Tsuchida N. (Oncogene 2006) 3 22 64
  5. Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. (PMID: 15738000) Harada A. … Negishi M. (J. Biol. Chem. 2005) 3 22 64

Products for FRS3 Gene

Sources for FRS3 Gene

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