Aliases for FRS3 Gene
External Ids for FRS3 Gene
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
GeneCards Summary for FRS3 Gene
FRS3 (Fibroblast Growth Factor Receptor Substrate 3) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include insulin receptor binding and fibroblast growth factor receptor binding.
UniProtKB/Swiss-Prot for FRS3 Gene
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.