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Aliases for FRS3 Gene

Aliases for FRS3 Gene

  • Fibroblast Growth Factor Receptor Substrate 3 2 3 5
  • FGFR-Signaling Adaptor SNT2 3 4
  • FGFR Substrate 3 3 4
  • SNT-2 3 4
  • Suc1-Associated Neurotrophic Factor Target 2 (FGFR Signalling Adaptor) 3
  • Suc1-Associated Neurotrophic Factor Target 2 4
  • Testicular Tissue Protein Li 71 3
  • FRS2-Beta 3
  • FRS2beta 3
  • FRS2B 3
  • SNT2 3

External Ids for FRS3 Gene

Previous GeneCards Identifiers for FRS3 Gene

  • GC06M041740
  • GC06M041784
  • GC06M041845
  • GC06M041737
  • GC06M041456

Summaries for FRS3 Gene

Entrez Gene Summary for FRS3 Gene

  • This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

GeneCards Summary for FRS3 Gene

FRS3 (Fibroblast Growth Factor Receptor Substrate 3) is a Protein Coding gene. Among its related pathways are RET signaling and Downstream signaling of activated FGFR2. GO annotations related to this gene include insulin receptor binding and fibroblast growth factor receptor binding. An important paralog of this gene is FRS2.

UniProtKB/Swiss-Prot for FRS3 Gene

  • Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Gene Wiki entry for FRS3 Gene

Additional gene information for FRS3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRS3 Gene

Genomics for FRS3 Gene

Regulatory Elements for FRS3 Gene

Enhancers for FRS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H041934 1.8 FANTOM5 ENCODE dbSUPER 21.3 -152.2 -152164 8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ENSG00000124593 MED20 USP49 FRS3 ENSG00000207371 BYSL RNU6-761P RPL7L1 PRICKLE4 TOMM6
GH06H041784 1.2 ENCODE 22.9 +0.3 324 4 HDGF FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 SLC30A9 ENSG00000124593 MED20 FRS3 USP49 BICRAL BYSL ENSG00000207371 GUCA1B PGC PRICKLE4
GH06H042020 2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -238.9 -238855 8 HDGF PKNOX1 FOXA2 ARNT ZNF766 ZNF143 ZNF207 FOS REST ZNF592 ENSG00000124593 MED20 CCND3 TAF8 USP49 PRICKLE4 FRS3 ENSG00000207371 BYSL TOMM6
GH06H042040 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -259.8 -259787 10 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ENSG00000124593 CCND3 RNU6-761P MED20 ENSG00000207371 BYSL FRS3 PRICKLE4 USP49 TOMM6
GH06H042029 1.5 Ensembl ENCODE dbSUPER 11.4 -244.3 -244310 1 HDGF ATF1 ARNT TCF12 ZNF766 GATA2 FOS ATF7 NCOA1 ZNF592 ENSG00000124593 USP49 FRS3 PRICKLE4 TOMM6 MED20 ENSG00000207371 BYSL ENSG00000206977 GUCA1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FRS3 on UCSC Golden Path with GeneCards custom track

Promoters for FRS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196887 -1058 2401 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A ZNF2 YY1

Genomic Location for FRS3 Gene

Chromosome:
6
Start:
41,770,176 bp from pter
End:
41,786,542 bp from pter
Size:
16,367 bases
Orientation:
Minus strand

Genomic View for FRS3 Gene

Genes around FRS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRS3 Gene

Proteins for FRS3 Gene

  • Protein details for FRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43559-FRS3_HUMAN
    Recommended name:
    Fibroblast growth factor receptor substrate 3
    Protein Accession:
    O43559
    Secondary Accessions:
    • Q5T3D5

    Protein attributes for FRS3 Gene

    Size:
    492 amino acids
    Molecular mass:
    54462 Da
    Quaternary structure:
    • Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.
    SequenceCaution:
    • Sequence=CAI13184.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FRS3 Gene

neXtProt entry for FRS3 Gene

Post-translational modifications for FRS3 Gene

  • Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRS3 Gene

No data available for DME Specific Peptides for FRS3 Gene

Domains & Families for FRS3 Gene

Gene Families for FRS3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FRS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FRS3: view

No data available for UniProtKB/Swiss-Prot for FRS3 Gene

Function for FRS3 Gene

Molecular function for FRS3 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Phenotypes From GWAS Catalog for FRS3 Gene

Gene Ontology (GO) - Molecular Function for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IPI 9660748
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 18985028
GO:0042802 identical protein binding IPI 25814554
genes like me logo Genes that share ontologies with FRS3: view
genes like me logo Genes that share phenotypes with FRS3: view

Animal Model Products

CRISPR Products

miRNA for FRS3 Gene

miRTarBase miRNAs that target FRS3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FRS3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRS3 Gene

Localization for FRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRS3 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRS3 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FRS3: view

Pathways & Interactions for FRS3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Negative regulation of FGFR1 signaling
4 NGF Pathway
5 Developmental Biology
genes like me logo Genes that share pathways with FRS3: view

Gene Ontology (GO) - Biological Process for FRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction TAS 8761293
GO:0008543 fibroblast growth factor receptor signaling pathway IGI 9660748
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with FRS3: view

No data available for SIGNOR curated interactions for FRS3 Gene

Drugs & Compounds for FRS3 Gene

(1) Drugs for FRS3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FRS3: view

Transcripts for FRS3 Gene

Unigene Clusters for FRS3 Gene

Fibroblast growth factor receptor substrate 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FRS3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FRS3 Gene

No ASD Table

Relevant External Links for FRS3 Gene

GeneLoc Exon Structure for
FRS3
ECgene alternative splicing isoforms for
FRS3

Expression for FRS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FRS3 Gene:

FRS3

SOURCE GeneReport for Unigene cluster for FRS3 Gene:

Hs.194208

Evidence on tissue expression from TISSUES for FRS3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FRS3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRS3 Gene

Orthologs for FRS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRS3 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia FRS3 33 34
  • 90.72 (n)
cow
(Bos Taurus)
Mammalia FRS3 33 34
  • 89.63 (n)
rat
(Rattus norvegicus)
Mammalia Frs3 33
  • 86 (n)
mouse
(Mus musculus)
Mammalia Frs3 33 16 34
  • 84.7 (n)
oppossum
(Monodelphis domestica)
Mammalia FRS3 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRS3 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FRS3 33 34
  • 69.32 (n)
lizard
(Anolis carolinensis)
Reptilia FRS3 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frs3 33
  • 65.06 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330147 33
  • 62.16 (n)
FRS3 34
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13398 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rog-1 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for FRS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRS3 Gene

ENSEMBL:
Gene Tree for FRS3 (if available)
TreeFam:
Gene Tree for FRS3 (if available)

Paralogs for FRS3 Gene

Paralogs for FRS3 Gene

(1) SIMAP similar genes for FRS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FRS3: view

Variants for FRS3 Gene

Sequence variations from dbSNP and Humsavar for FRS3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000013226 -- 41,774,282(+) TTCCC(C/T)CATCT intron-variant
rs1000089694 -- 41,773,144(+) GTTGC(C/G)CAGGC intron-variant
rs1000699759 -- 41,774,710(+) GCTAC(A/G)TGGGG intron-variant
rs1000991174 -- 41,776,723(+) ATCAA(C/G)AGCCA intron-variant
rs1001140650 -- 41,774,790(+) AATAG(A/G)ATGGG intron-variant

Variation tolerance for FRS3 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FRS3 Gene

Disorders for FRS3 Gene

Relevant External Links for FRS3

Genetic Association Database (GAD)
FRS3
Human Genome Epidemiology (HuGE) Navigator
FRS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRS3

No disorders were found for FRS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRS3 Gene

Publications for FRS3 Gene

  1. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. (PMID: 15485655) Huang L … Tsuchida N (Biochemical and biophysical research communications 2004) 3 4 22 60
  2. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. (PMID: 9660748) Xu H … Goldfarb M (The Journal of biological chemistry 1998) 2 3 4 60
  3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 45 60
  4. Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. (PMID: 16702953) Huang L … Tsuchida N (Oncogene 2006) 3 22 60
  5. Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. (PMID: 15738000) Harada A … Negishi M (The Journal of biological chemistry 2005) 3 22 60

Products for FRS3 Gene

Sources for FRS3 Gene

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