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Aliases for FRS2 Gene

Aliases for FRS2 Gene

  • Fibroblast Growth Factor Receptor Substrate 2 2 3
  • Suc1-Associated Neurotrophic Factor Target 1 3 4
  • FGFR-Signaling Adaptor SNT 3 4
  • FGFR Substrate 2 3 4
  • SNT-1 3 4
  • FGFR Signalling Adaptor 3
  • FRS2alpha 3
  • FRS2A 3
  • SNT1 3
  • SNT 3

External Ids for FRS2 Gene

Previous GeneCards Identifiers for FRS2 Gene

  • GC12P069580
  • GC12P068150
  • GC12P069864
  • GC12P066913

Summaries for FRS2 Gene

GeneCards Summary for FRS2 Gene

FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is a Protein Coding gene. Diseases associated with FRS2 include nasal cavity squamous cell carcinoma. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include insulin receptor binding and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is FRS3.

UniProtKB/Swiss-Prot for FRS2 Gene

  • Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Gene Wiki entry for FRS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRS2 Gene

Genomics for FRS2 Gene

Regulatory Elements for FRS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FRS2 Gene

Chromosome:
12
Start:
69,470,349 bp from pter
End:
69,579,793 bp from pter
Size:
109,445 bases
Orientation:
Plus strand

Genomic View for FRS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRS2 Gene

Proteins for FRS2 Gene

  • Protein details for FRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU20-FRS2_HUMAN
    Recommended name:
    Fibroblast growth factor receptor substrate 2
    Protein Accession:
    Q8WU20
    Secondary Accessions:
    • B0LPF2
    • B2R684
    • O43558
    • Q7LDQ6

    Protein attributes for FRS2 Gene

    Size:
    508 amino acids
    Molecular mass:
    57029 Da
    Quaternary structure:
    • Part of a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Part of a complex containing GRB2 and CBL. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds RET (By similarity). Binds ALK, FGFR1, CKS2, MAPK1/ERK2, MAPK3/ERK1 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated upon ligand-binding).
    SequenceCaution:
    • Sequence=AAH21562.1; Type=Erroneous termination; Positions=509; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAG35381.1; Type=Erroneous termination; Positions=509; Note=Translated as stop.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FRS2 Gene

neXtProt entry for FRS2 Gene

Proteomics data for FRS2 Gene at MOPED

Post-translational modifications for FRS2 Gene

  • Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.
  • Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FRS2 (FRS2)

No data available for DME Specific Peptides for FRS2 Gene

Domains & Families for FRS2 Gene

Protein Domains for FRS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WU20

UniProtKB/Swiss-Prot:

FRS2_HUMAN :
  • Contains 1 IRS-type PTB domain.
Domain:
  • Contains 1 IRS-type PTB domain.
genes like me logo Genes that share domains with FRS2: view

No data available for Gene Families for FRS2 Gene

Function for FRS2 Gene

Molecular function for FRS2 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Gene Ontology (GO) - Molecular Function for FRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS 9660748
GO:0005104 fibroblast growth factor receptor binding IPI 9660748
GO:0005158 insulin receptor binding IEA --
GO:0005168 neurotrophin TRKA receptor binding IPI 15488758
GO:0005515 protein binding IPI 9660748
genes like me logo Genes that share ontologies with FRS2: view
genes like me logo Genes that share phenotypes with FRS2: view

Animal Models for FRS2 Gene

MGI Knock Outs for FRS2:

Animal Model Products

miRNA for FRS2 Gene

miRTarBase miRNAs that target FRS2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FRS2 Gene

Localization for FRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRS2 Gene

Endomembrane system. Note=Cytoplasmic, membrane-bound.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRS2 Gene COMPARTMENTS Subcellular localization image for FRS2 gene
Compartment Confidence
plasma membrane 5
endosome 4
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for FRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005768 endosome TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9660748
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with FRS2: view

Pathways & Interactions for FRS2 Gene

SuperPathways for FRS2 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 PI3K/AKT Signaling in Cancer
3 Negative regulation of FGFR3 signaling
4 SHC-mediated cascade-FGFR1
5 Immune System
genes like me logo Genes that share pathways with FRS2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for FRS2 Gene

SIGNOR curated interactions for FRS2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity IEA --
GO:0001702 gastrulation with mouth forming second IEA --
GO:0001759 organ induction IEA --
genes like me logo Genes that share ontologies with FRS2: view

Drugs & Compounds for FRS2 Gene

(4) Drugs for FRS2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
phenylalanine Nutra 130
serine Nutra 420
threonine Nutra 16
tyrosine Nutra 547

(1) Additional Compounds for FRS2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphotyrosine
genes like me logo Genes that share compounds with FRS2: view

Transcripts for FRS2 Gene

mRNA/cDNA for FRS2 Gene

Unigene Clusters for FRS2 Gene

Fibroblast growth factor receptor substrate 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for FRS2 Gene

GeneLoc Exon Structure for
FRS2
ECgene alternative splicing isoforms for
FRS2

Expression for FRS2 Gene

mRNA expression in normal human tissues for FRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FRS2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FRS2 Gene



SOURCE GeneReport for Unigene cluster for FRS2 Gene Hs.593446

mRNA Expression by UniProt/SwissProt for FRS2 Gene

Q8WU20-FRS2_HUMAN
Tissue specificity: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
genes like me logo Genes that share expression patterns with FRS2: view

Protein tissue co-expression partners for FRS2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FRS2 Gene

Orthologs for FRS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FRS2 35
  • 94.82 (n)
  • 98.23 (a)
FRS2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRS2 35
  • 96.19 (n)
  • 99.21 (a)
FRS2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frs2 35
  • 89.7 (n)
  • 95.87 (a)
Frs2 16
Frs2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FRS2 35
  • 99.67 (n)
  • 99.61 (a)
FRS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frs2 35
  • 90.29 (n)
  • 95.47 (a)
oppossum
(Monodelphis domestica)
Mammalia FRS2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRS2 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves FRS2 35
  • 86.42 (n)
  • 92.72 (a)
FRS2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRS2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frs2 35
  • 77.58 (n)
  • 83.13 (a)
Str.3189 35
African clawed frog
(Xenopus laevis)
Amphibia frs2-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5313 35
frs2a 35
  • 65.47 (n)
  • 71.88 (a)
frs2a 36
  • 69 (a)
OneToMany
frs2b 36
  • 59 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13274 35
fruit fly
(Drosophila melanogaster)
Insecta CG13398 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rog-1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for FRS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRS2 Gene

ENSEMBL:
Gene Tree for FRS2 (if available)
TreeFam:
Gene Tree for FRS2 (if available)

Paralogs for FRS2 Gene

Paralogs for FRS2 Gene

(5) SIMAP similar genes for FRS2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FRS2: view

Variants for FRS2 Gene

Sequence variations from dbSNP and Humsavar for FRS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2896 -- 69,483,624(-) TTAAT(A/T)TAAAG intron-variant
rs3201 -- 69,579,612(-) ACCTC(A/G)TTATG utr-variant-3-prime
rs3202 -- 69,579,567(-) GCAAA(A/G)TCCAA utr-variant-3-prime
rs221069 -- 69,468,459(-) Ccagt(A/G)gttct upstream-variant-2KB
rs221070 -- 69,470,390(-) GAATC(C/T)TGGAA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FRS2 Gene

Variant ID Type Subtype PubMed ID
esv991802 CNV Gain 20482838
nsv761 CNV Insertion 18451855

Variation tolerance for FRS2 Gene

Residual Variation Intolerance Score: 12.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRS2 Gene

HapMap Linkage Disequilibrium report
FRS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRS2 Gene

Disorders for FRS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FRS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nasal cavity squamous cell carcinoma
  • squamous cell carcinoma of the nasal cavity
- elite association
Search FRS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FRS2

Genetic Association Database (GAD)
FRS2
Human Genome Epidemiology (HuGE) Navigator
FRS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRS2
genes like me logo Genes that share disorders with FRS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FRS2 Gene

Publications for FRS2 Gene

  1. The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons. (PMID: 19943849) Hryciw T. … Meakin S.O. (J. Neurochem. 2010) 23 67
  2. The fibroblast growth factor receptor (FGFR) agonist FGF1 and the neural cell adhesion molecule-derived peptide FGL activate FGFR substrate 2alpha differently. (PMID: 20175207) Chen Y. … Bock E. (J. Neurosci. Res. 2010) 23 67
  3. Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. (PMID: 20460524) Dey J.H. … Hynes N.E. (Cancer Res. 2010) 23 67
  4. Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform. (PMID: 19103595) Cha J.Y. … Der C.J. (J. Biol. Chem. 2009) 23 67
  5. An in vitro analysis of mechanical wounding-induced ligand-independent KGFR activation. (PMID: 19111446) Li M. … Putnins E.E. (J. Dermatol. Sci. 2009) 23 67

Products for FRS2 Gene

Sources for FRS2 Gene

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