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Aliases for FRS2 Gene

Aliases for FRS2 Gene

  • Fibroblast Growth Factor Receptor Substrate 2 2 3
  • Suc1-Associated Neurotrophic Factor Target 1 3 4
  • FGFR-Signaling Adaptor SNT 3 4
  • FGFR Substrate 2 3 4
  • SNT-1 3 4
  • FGFR Signalling Adaptor 3
  • FRS2alpha 3
  • FRS2A 3
  • SNT1 3
  • SNT 3

External Ids for FRS2 Gene

Summaries for FRS2 Gene

GeneCards Summary for FRS2 Gene

FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is a Protein Coding gene. Diseases associated with FRS2 include opioid abuse. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include insulin receptor binding and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is FRS3.

UniProtKB/Swiss-Prot for FRS2 Gene

  • Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Gene Wiki entry for FRS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRS2 Gene

Genomics for FRS2 Gene

Genomic Location for FRS2 Gene

Start:
69,470,349 bp from pter
End:
69,579,793 bp from pter
Size:
109,445 bases
Orientation:
Plus strand

Genomic View for FRS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRS2 Gene

Regulatory Elements for FRS2 Gene

Proteins for FRS2 Gene

  • Protein details for FRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU20-FRS2_HUMAN
    Recommended name:
    Fibroblast growth factor receptor substrate 2
    Protein Accession:
    Q8WU20
    Secondary Accessions:
    • B0LPF2
    • B2R684
    • O43558
    • Q7LDQ6

    Protein attributes for FRS2 Gene

    Size:
    508 amino acids
    Molecular mass:
    57029 Da
    Quaternary structure:
    • Part of a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Part of a complex containing GRB2 and CBL. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds RET (By similarity). Binds ALK, FGFR1, CKS2, MAPK1/ERK2, MAPK3/ERK1 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated upon ligand-binding).
    SequenceCaution:
    • Sequence=AAH21562.1; Type=Erroneous termination; Positions=509; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAG35381.1; Type=Erroneous termination; Positions=509; Note=Translated as stop.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FRS2 Gene

neXtProt entry for FRS2 Gene

Proteomics data for FRS2 Gene at MOPED

Post-translational modifications for FRS2 Gene

  • Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.
  • Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRS2 Gene

Domains for FRS2 Gene

Protein Domains for FRS2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FRS2_HUMAN
Domain:
  • Contains 1 IRS-type PTB domain.:
    • Q8WU20
genes like me logo Genes that share domains with FRS2: view

No data available for Gene Families for FRS2 Gene

Function for FRS2 Gene

Molecular function for FRS2 Gene

UniProtKB/Swiss-Prot Function: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Gene Ontology (GO) - Molecular Function for FRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS 9660748
GO:0005104 fibroblast growth factor receptor binding IPI 9660748
GO:0005158 insulin receptor binding IEA --
GO:0005168 neurotrophin TRKA receptor binding IPI 15488758
GO:0005515 protein binding IPI 9660748
genes like me logo Genes that share ontologies with FRS2: view
genes like me logo Genes that share phenotypes with FRS2: view

Animal Models for FRS2 Gene

MGI Knock Outs for FRS2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FRS2 Gene

Localization for FRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRS2 Gene

Endomembrane system. Note=Cytoplasmic, membrane-bound.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRS2 Gene COMPARTMENTS Subcellular localization image for FRS2 gene
Compartment Confidence
plasma membrane 5
endosome 4
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005768 endosome TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9660748
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with FRS2: view

Pathways for FRS2 Gene

genes like me logo Genes that share pathways with FRS2: view

Interacting Proteins for FRS2 Gene

Gene Ontology (GO) - Biological Process for FRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity IEA --
GO:0001702 gastrulation with mouth forming second IEA --
GO:0001759 organ induction IEA --
GO:0002088 lens development in camera-type eye --
genes like me logo Genes that share ontologies with FRS2: view

Compounds for FRS2 Gene

(5) Novoseek inferred chemical compound relationships for FRS2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 70.8 45
phosphotyrosine 60.6 4
phenylalanine 39.3 1
threonine 16.7 6
serine 0.166 5
genes like me logo Genes that share compounds with FRS2: view

Transcripts for FRS2 Gene

mRNA/cDNA for FRS2 Gene

Unigene Clusters for FRS2 Gene

Fibroblast growth factor receptor substrate 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for FRS2 Gene

GeneLoc Exon Structure for
FRS2
ECgene alternative splicing isoforms for
FRS2

Expression for FRS2 Gene

mRNA expression in normal human tissues for FRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FRS2 Gene

SOURCE GeneReport for Unigene cluster for FRS2 Gene Hs.593446

mRNA Expression by UniProt/SwissProt for FRS2 Gene

Q8WU20-FRS2_HUMAN
Tissue specificity: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
genes like me logo Genes that share expressions with FRS2: view

Orthologs for FRS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRS2 36
  • 99.67 (n)
  • 99.61 (a)
FRS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRS2 36
  • 94.82 (n)
  • 98.23 (a)
FRS2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRS2 36
  • 96.19 (n)
  • 99.21 (a)
FRS2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frs2 36
  • 89.7 (n)
  • 95.87 (a)
Frs2 16
Frs2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRS2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRS2 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frs2 36
  • 90.29 (n)
  • 95.47 (a)
chicken
(Gallus gallus)
Aves FRS2 36
  • 86.42 (n)
  • 92.72 (a)
FRS2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRS2 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia frs2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia frs2 36
  • 77.58 (n)
  • 83.13 (a)
Str.3189 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13274 36
zebrafish
(Danio rerio)
Actinopterygii Dr.5313 36
frs2a 36
  • 65.47 (n)
  • 71.88 (a)
frs2a 37
  • 69 (a)
OneToMany
frs2b 37
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13398 37
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rog-1 37
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
OneToMany
Species with no ortholog for FRS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRS2 Gene

ENSEMBL:
Gene Tree for FRS2 (if available)
TreeFam:
Gene Tree for FRS2 (if available)

Paralogs for FRS2 Gene

Paralogs for FRS2 Gene

Selected SIMAP similar genes for FRS2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FRS2: view

Variants for FRS2 Gene

Sequence variations from dbSNP and Humsavar for FRS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2896 -- 69,483,624(-) TTAAT(A/T)TAAAG intron-variant
rs3201 -- 69,579,612(-) ACCTC(A/G)TTATG utr-variant-3-prime
rs3202 -- 69,579,567(-) GCAAA(A/G)TCCAA utr-variant-3-prime
rs221069 -- 69,468,459(-) Ccagt(A/G)gttct upstream-variant-2KB
rs221070 -- 69,470,390(-) GAATC(C/T)TGGAA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FRS2 Gene

Variant ID Type Subtype PubMed ID
esv991802 CNV Gain 20482838
nsv761 CNV Insertion 18451855

Relevant External Links for FRS2 Gene

HapMap Linkage Disequilibrium report
FRS2

Disorders for FRS2 Gene

(1) MalaCards Diseases for FRS2 Gene

Search for FRS2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FRS2 Gene

(3) Novoseek inferred disease relationships for FRS2 Gene

Disease -log(P) Hits PubMed IDs
pheochromocytoma 14.9 1
cancer 8.69 2
tumors 0 1

Relevant External Links for FRS2

Genetic Association Database (GAD)
FRS2
Human Genome Epidemiology (HuGE) Navigator
FRS2
genes like me logo Genes that share disorders with FRS2: view

No data available for UniProtKB/Swiss-Prot for FRS2 Gene

Publications for FRS2 Gene

  1. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. (PMID: 10092678) Meakin S.O. … Verdi J.M. (J. Biol. Chem. 1999) 3 4 23
  2. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. (PMID: 12974390) Wu Y. … Ullrich A. (Biol. Chem. 2003) 3 4 23
  3. Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. (PMID: 18591461) Turner S.T. … Boerwinkle E. (Hypertension 2008) 3 23 49
  4. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. (PMID: 9660748) Xu H. … Goldfarb M.P. (J. Biol. Chem. 1998) 2 3 4
  5. Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras. (PMID: 8761293) Wang J.K. … Goldfarb M. (Oncogene 1996) 2 3

Products for FRS2 Gene

Sources for FRS2 Gene

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