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Aliases for FRRS1L Gene

Aliases for FRRS1L Gene

  • Ferric Chelate Reductase 1 Like 2 3
  • Ferric-Chelate Reductase 1-Like Protein 3 4
  • Ferric-Chelate Reductase 1-Like 2 5
  • Brain Protein CG-6 3 4
  • C9orf4 3 4
  • Chromosome 9 Open Reading Frame 4 2
  • CG-6 3
  • CG6 3

External Ids for FRRS1L Gene

Previous HGNC Symbols for FRRS1L Gene

  • C9orf4

Previous GeneCards Identifiers for FRRS1L Gene

  • GC09M111900

Summaries for FRRS1L Gene

GeneCards Summary for FRRS1L Gene

FRRS1L (Ferric Chelate Reductase 1 Like) is a Protein Coding gene. An important paralog of this gene is FRRS1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRRS1L Gene

Genomics for FRRS1L Gene

Regulatory Elements for FRRS1L Gene

Enhancers for FRRS1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FRRS1L on UCSC Golden Path with GeneCards custom track

Promoters for FRRS1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FRRS1L on UCSC Golden Path with GeneCards custom track

Genomic Location for FRRS1L Gene

109,130,293 bp from pter
109,167,291 bp from pter
36,999 bases
Minus strand

Genomic View for FRRS1L Gene

Genes around FRRS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRRS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRRS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRRS1L Gene

Proteins for FRRS1L Gene

  • Protein details for FRRS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DOMON domain-containing protein FRRS1L
    Protein Accession:
    Secondary Accessions:
    • Q5T4G4

    Protein attributes for FRRS1L Gene

    344 amino acids
    Molecular mass:
    37270 Da
    Quaternary structure:
    • Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for FRRS1L Gene

Proteomics data for FRRS1L Gene at MOPED

Post-translational modifications for FRRS1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRRS1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRRS1L Gene

Domains & Families for FRRS1L Gene

Protein Domains for FRRS1L Gene


Suggested Antigen Peptide Sequences for FRRS1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DOMON domain.
  • Contains 1 DOMON domain.
genes like me logo Genes that share domains with FRRS1L: view

No data available for Gene Families for FRRS1L Gene

Function for FRRS1L Gene

genes like me logo Genes that share phenotypes with FRRS1L: view

Animal Models for FRRS1L Gene

MGI Knock Outs for FRRS1L:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRRS1L Gene

Localization for FRRS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRRS1L Gene

Cell membrane. Cell junction, synapse.

Subcellular locations from

Jensen Localization Image for FRRS1L Gene COMPARTMENTS Subcellular localization image for FRRS1L gene
Compartment Confidence
plasma membrane 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FRRS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with FRRS1L: view

Pathways & Interactions for FRRS1L Gene

SuperPathways for FRRS1L Gene

No Data Available

Interacting Proteins for FRRS1L Gene

Gene Ontology (GO) - Biological Process for FRRS1L Gene


No data available for Pathways by source and SIGNOR curated interactions for FRRS1L Gene

Drugs & Compounds for FRRS1L Gene

No Compound Related Data Available

Transcripts for FRRS1L Gene

mRNA/cDNA for FRRS1L Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRRS1L Gene

Ferric-chelate reductase 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRRS1L Gene

No ASD Table

Relevant External Links for FRRS1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRRS1L Gene

mRNA expression in normal human tissues for FRRS1L Gene

mRNA differential expression in normal tissues according to GTEx for FRRS1L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Frontal Cortex (BA9) (x4.9), Brain - Cerebellar Hemisphere (x4.7), Brain - Cerebellum (x4.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for FRRS1L Gene

This gene is overexpressed in Frontal cortex (45.0) and Fetal Brain (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FRRS1L Gene

SOURCE GeneReport for Unigene cluster for FRRS1L Gene Hs.347537

mRNA Expression by UniProt/SwissProt for FRRS1L Gene

Tissue specificity: Expressed in adult and fetal brain. Very weak expression in medulla, spinal cord and in adult ovary.
genes like me logo Genes that share expression patterns with FRRS1L: view

Protein tissue co-expression partners for FRRS1L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FRRS1L Gene

Orthologs for FRRS1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for FRRS1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FRRS1L 35
  • 92.4 (n)
  • 95.31 (a)
  • 87 (a)
(Canis familiaris)
Mammalia FRRS1L 35
  • 94.37 (n)
  • 99.53 (a)
  • 87 (a)
(Mus musculus)
Mammalia Frrs1l 35
  • 87.94 (n)
  • 92.83 (a)
Frrs1l 16
Frrs1l 36
  • 92 (a)
(Pan troglodytes)
Mammalia FRRS1L 35
  • 99.52 (n)
  • 99.71 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Frrs1l 35
  • 87.71 (n)
  • 92.36 (a)
(Monodelphis domestica)
Mammalia FRRS1L 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia FRRS1L 36
  • 98 (a)
(Gallus gallus)
Aves C9ORF4 35
  • 84.64 (n)
  • 96.77 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia FRRS1L 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490518 35
  • 75.95 (n)
  • 88.93 (a)
(Danio rerio)
Actinopterygii LOC100536668 35
  • 76.6 (n)
  • 85.96 (a)
  • 75 (a)
Species with no ortholog for FRRS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FRRS1L Gene

Gene Tree for FRRS1L (if available)
Gene Tree for FRRS1L (if available)

Paralogs for FRRS1L Gene

Paralogs for FRRS1L Gene

genes like me logo Genes that share paralogs with FRRS1L: view

Variants for FRRS1L Gene

Sequence variations from dbSNP and Humsavar for FRRS1L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs999729 -- 109,149,543(-) ATCAG(C/G)GGGCC intron-variant
rs999730 -- 109,149,261(-) TTTTT(A/C)GTAAA intron-variant
rs7468610 -- 109,165,856(+) agtta(A/C/T)tttga intron-variant, upstream-variant-2KB
rs7848988 -- 109,160,874(+) TGCAA(C/G)CTCCG intron-variant
rs7851928 -- 109,136,819(+) TGCTC(A/G)GCCAA downstream-variant-500B, utr-variant-3-prime

Variation tolerance for FRRS1L Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FRRS1L Gene

Disorders for FRRS1L Gene

Relevant External Links for FRRS1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRRS1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRRS1L Gene

Publications for FRRS1L Gene

  1. Cloning, mapping, and expression of a novel brain-specific transcript in the familial dysautonomia candidate region on chromosome 9q31. (PMID: 10603000) Chadwick B.P. … Slaugenhaupt S.A. (Mamm. Genome 2000) 2 3 4 67
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3

Products for FRRS1L Gene

Sources for FRRS1L Gene