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Aliases for FRRS1L Gene

Aliases for FRRS1L Gene

  • Ferric-Chelate Reductase 1-Like 2 3
  • C9orf4 3 4 6
  • Ferric-Chelate Reductase 1-Like Protein 3 4
  • Brain Protein CG-6 3 4
  • CG6 3 6
  • DOMON Domain-Containing Protein FRRS1L 3
  • Chromosome 9 Open Reading Frame 4 2
  • CG-6 3

External Ids for FRRS1L Gene

Previous HGNC Symbols for FRRS1L Gene

  • C9orf4

Previous GeneCards Identifiers for FRRS1L Gene

  • GC09M111900

Summaries for FRRS1L Gene

GeneCards Summary for FRRS1L Gene

FRRS1L (Ferric-Chelate Reductase 1-Like) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRRS1L Gene

Genomics for FRRS1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FRRS1L Gene

Start:
109,130,293 bp from pter
End:
109,167,291 bp from pter
Size:
36,999 bases
Orientation:
Minus strand

Genomic View for FRRS1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRRS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRRS1L Gene

No data available for Regulatory Elements for FRRS1L Gene

Proteins for FRRS1L Gene

  • Protein details for FRRS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0K9-FRS1L_HUMAN
    Recommended name:
    DOMON domain-containing protein FRRS1L
    Protein Accession:
    Q9P0K9
    Secondary Accessions:
    • Q5T4G4

    Protein attributes for FRRS1L Gene

    Size:
    344 amino acids
    Molecular mass:
    37270 Da
    Quaternary structure:
    • Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for FRRS1L Gene

Proteomics data for FRRS1L Gene at MOPED

Post-translational modifications for FRRS1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRRS1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRRS1L Gene

Domains for FRRS1L Gene

Protein Domains for FRRS1L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P0K9

UniProtKB/Swiss-Prot:

FRS1L_HUMAN :
  • Q9P0K9
Domain:
  • Contains 1 DOMON domain.
genes like me logo Genes that share domains with FRRS1L: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FRRS1L Gene

Function for FRRS1L Gene

Gene Ontology (GO) - Molecular Function for FRRS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FRRS1L: view
genes like me logo Genes that share phenotypes with FRRS1L: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRRS1L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FRRS1L Gene

Localization for FRRS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRRS1L Gene

Cell membrane. Cell junction, synapse.

Gene Ontology (GO) - Cellular Components for FRRS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with FRRS1L: view

No data available for Subcellular locations from COMPARTMENTS for FRRS1L Gene

Pathways for FRRS1L Gene

SuperPathways for FRRS1L Gene

No Data Available

Interacting Proteins for FRRS1L Gene

Gene Ontology (GO) - Biological Process for FRRS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FRRS1L: view

No data available for Pathways by source for FRRS1L Gene

Transcripts for FRRS1L Gene

mRNA/cDNA for FRRS1L Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRRS1L Gene

Ferric-chelate reductase 1-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRRS1L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRRS1L Gene

No ASD Table

Relevant External Links for FRRS1L Gene

GeneLoc Exon Structure for
FRRS1L
ECgene alternative splicing isoforms for
FRRS1L

Expression for FRRS1L Gene

mRNA expression in normal human tissues for FRRS1L Gene

mRNA differential expression in normal tissues according to GTEx for FRRS1L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.2), Brain - Anterior cingulate cortex (BA24) (4.9), Brain - Frontal Cortex (BA9) (4.9), Brain - Cerebellar Hemisphere (4.7), Brain - Cerebellum (4.1), and Brain - Cortex (4.0).

Protein differential expression in normal tissues for FRRS1L Gene

This gene is overexpressed in Frontal cortex (45.0) and Fetal Brain (17.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FRRS1L Gene

SOURCE GeneReport for Unigene cluster for FRRS1L Gene Hs.347537

mRNA Expression by UniProt/SwissProt for FRRS1L Gene

Q9P0K9-FRS1L_HUMAN
Tissue specificity: Expressed in adult and fetal brain. Very weak expression in medulla, spinal cord and in adult ovary.
genes like me logo Genes that share expressions with FRRS1L: view

Expression partners for FRRS1L Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FRRS1L Gene

Orthologs for FRRS1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for FRRS1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FRRS1L 35
  • 92.4 (n)
  • 95.31 (a)
FRRS1L 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRRS1L 35
  • 94.37 (n)
  • 99.53 (a)
FRRS1L 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frrs1l 35
  • 87.94 (n)
  • 92.83 (a)
Frrs1l 16
Frrs1l 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FRRS1L 35
  • 99.52 (n)
  • 99.71 (a)
FRRS1L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frrs1l 35
  • 87.71 (n)
  • 92.36 (a)
oppossum
(Monodelphis domestica)
Mammalia FRRS1L 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRRS1L 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves C9ORF4 35
  • 84.64 (n)
  • 96.77 (a)
FRRS1L 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRRS1L 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490518 35
  • 75.95 (n)
  • 88.93 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536668 35
  • 76.6 (n)
  • 85.96 (a)
FRRS1L 36
  • 75 (a)
OneToOne
Species with no ortholog for FRRS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FRRS1L Gene

ENSEMBL:
Gene Tree for FRRS1L (if available)
TreeFam:
Gene Tree for FRRS1L (if available)

Paralogs for FRRS1L Gene

No data available for Paralogs for FRRS1L Gene

Variants for FRRS1L Gene

Sequence variations from dbSNP and Humsavar for FRRS1L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs999729 -- 109,149,543(-) ATCAG(C/G)GGGCC intron-variant
rs999730 -- 109,149,261(-) TTTTT(A/C)GTAAA intron-variant
rs1467242 -- 109,151,174(-) TACTT(C/T)GGTGG intron-variant
rs1467243 -- 109,151,055(-) TTAAA(C/G)TATAA intron-variant
rs1533641 -- 109,149,495(-) CGTAA(C/T)GGCCA intron-variant

Relevant External Links for FRRS1L Gene

HapMap Linkage Disequilibrium report
FRRS1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FRRS1L Gene

Disorders for FRRS1L Gene

No disorders were found for FRRS1L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FRRS1L Gene

Publications for FRRS1L Gene

  1. Cloning, mapping, and expression of a novel brain-specific transcript in the familial dysautonomia candidate region on chromosome 9q31. (PMID: 10603000) Chadwick B.P. … Slaugenhaupt S.A. (Mamm. Genome 2000) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for FRRS1L Gene

Sources for FRRS1L Gene

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