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Aliases for FRRS1 Gene

Aliases for FRRS1 Gene

  • Ferric-Chelate Reductase 1 2 3
  • SDR2 3 4 6
  • Stromal Cell-Derived Receptor 2 3 4
  • SDFR2 3 4
  • SDR-2 3 4
  • Stromal Cell Derived Factor Receptor 2 Homolog (Mouse) 2
  • Stromal Cell Derived Factor Receptor 2 Homolog 3
  • EC 1.-.-.- 4

External Ids for FRRS1 Gene

Previous HGNC Symbols for FRRS1 Gene

  • SDFR2

Previous GeneCards Identifiers for FRRS1 Gene

  • GC01M099946
  • GC01M100174
  • GC01M098296

Summaries for FRRS1 Gene

Entrez Gene Summary for FRRS1 Gene

  • Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FRRS1 Gene

FRRS1 (Ferric-Chelate Reductase 1) is a Protein Coding gene. Diseases associated with FRRS1 include multidrug-resistant tuberculosis. GO annotations related to this gene include ferric-chelate reductase activity.

UniProtKB/Swiss-Prot for FRRS1 Gene

  • Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRRS1 Gene

Genomics for FRRS1 Gene

Regulatory Elements for FRRS1 Gene

Genomic Location for FRRS1 Gene

Start:
99,708,650 bp from pter
End:
99,766,631 bp from pter
Size:
57,982 bases
Orientation:
Minus strand

Genomic View for FRRS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRRS1 Gene

Proteins for FRRS1 Gene

  • Protein details for FRRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNA5-FRRS1_HUMAN
    Recommended name:
    Ferric-chelate reductase 1
    Protein Accession:
    Q6ZNA5
    Secondary Accessions:
    • A6NLN7

    Protein attributes for FRRS1 Gene

    Size:
    592 amino acids
    Molecular mass:
    66114 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 2 heme groups non-covalently.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRRS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRRS1 Gene

Proteomics data for FRRS1 Gene at MOPED

Post-translational modifications for FRRS1 Gene

  • Glycosylation at Asn138, Asn308, and Asn321
  • Modification sites at PhosphoSitePlus

Other Protein References for FRRS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRRS1 Gene

Domains for FRRS1 Gene

Protein Domains for FRRS1 Gene

Suggested Antigen Peptide Sequences for FRRS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNA5

UniProtKB/Swiss-Prot:

FRRS1_HUMAN :
  • Q6ZNA5
Domain:
  • Contains 1 cytochrome b561 domain.
  • Contains 1 DOMON domain.
  • Contains 1 reelin domain.
Family:
  • Belongs to the FRRS1 family.
genes like me logo Genes that share domains with FRRS1: view

No data available for Gene Families for FRRS1 Gene

Function for FRRS1 Gene

Molecular function for FRRS1 Gene

UniProtKB/Swiss-Prot Function: Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.

Enzyme Numbers (IUBMB) for FRRS1 Gene

Gene Ontology (GO) - Molecular Function for FRRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000293 ferric-chelate reductase activity ISS 14499595
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FRRS1: view

Phenotypes for FRRS1 Gene

MGI mutant phenotypes for FRRS1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FRRS1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FRRS1 Gene

Localization for FRRS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRRS1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRRS1 Gene COMPARTMENTS Subcellular localization image for FRRS1 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for FRRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FRRS1: view

Pathways for FRRS1 Gene

SuperPathways for FRRS1 Gene

No Data Available

Interacting Proteins for FRRS1 Gene

Gene Ontology (GO) - Biological Process for FRRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FRRS1: view

No data available for Pathways by source for FRRS1 Gene

Compounds for FRRS1 Gene

(1) HMDB Compounds for FRRS1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
genes like me logo Genes that share compounds with FRRS1: view

Transcripts for FRRS1 Gene

mRNA/cDNA for FRRS1 Gene

(2) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRRS1 Gene

Ferric-chelate reductase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRRS1 Gene

No ASD Table

Relevant External Links for FRRS1 Gene

GeneLoc Exon Structure for
FRRS1
ECgene alternative splicing isoforms for
FRRS1

Expression for FRRS1 Gene

mRNA expression in normal human tissues for FRRS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRRS1 Gene

This gene is overexpressed in Liver (5.4) and Esophagus - Mucosa (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FRRS1 Gene

SOURCE GeneReport for Unigene cluster for FRRS1 Gene Hs.454779

genes like me logo Genes that share expressions with FRRS1: view

No data available for mRNA Expression by UniProt/SwissProt for FRRS1 Gene

Orthologs for FRRS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRRS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRRS1 35
  • 99.41 (n)
  • 99.36 (a)
FRRS1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRRS1 35
  • 86.77 (n)
  • 81.82 (a)
FRRS1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRRS1 35
  • 87.32 (n)
  • 82.75 (a)
FRRS1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frrs1 35
  • 79.51 (n)
  • 77.04 (a)
Frrs1 16
Frrs1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRRS1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRRS1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frrs1 35
  • 78.15 (n)
  • 75.84 (a)
chicken
(Gallus gallus)
Aves FRRS1 35
  • 68.03 (n)
  • 60.78 (a)
FRRS1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRRS1 36
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25809 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497064 35
  • 64.41 (n)
  • 61.2 (a)
Str.14076 35
zebrafish
(Danio rerio)
Actinopterygii FRRS1 (1 of 5) 36
  • 27 (a)
OneToMany
FRRS1 (2 of 5) 36
  • 29 (a)
OneToMany
FRRS1 (5 of 5) 36
  • 42 (a)
OneToMany
frrs1a 36
  • 42 (a)
OneToMany
frrs1a 36
  • 42 (a)
OneToMany
LOC100536707 35
  • 54.25 (n)
  • 46.68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005170 35
  • 42.22 (n)
  • 32.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14515 36
  • 22 (a)
OneToOne
CG8399 35
  • 42.12 (n)
  • 32.25 (a)
worm
(Caenorhabditis elegans)
Secernentea C05D12.1 35
  • 42.66 (n)
  • 30.06 (a)
M03A1.3 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for FRRS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRRS1 Gene

ENSEMBL:
Gene Tree for FRRS1 (if available)
TreeFam:
Gene Tree for FRRS1 (if available)

Paralogs for FRRS1 Gene

No data available for Paralogs for FRRS1 Gene

Variants for FRRS1 Gene

Sequence variations from dbSNP and Humsavar for FRRS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs903128 -- 99,766,780(-) TCTAA(A/G)TTTTC upstream-variant-2KB
rs951123 -- 99,732,542(+) GCAGA(C/T)CTTAG intron-variant
rs951124 -- 99,732,600(+) GAAAG(A/G)TTTTC intron-variant
rs951125 -- 99,732,503(+) GAGAA(C/T)TGAAA intron-variant
rs953019 -- 99,722,760(-) aatgc(A/G)tctga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRRS1 Gene

Variant ID Type Subtype PubMed ID
nsv526047 CNV Gain 19592680
esv24594 CNV Loss 19812545

Relevant External Links for FRRS1 Gene

HapMap Linkage Disequilibrium report
FRRS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRRS1 Gene

Disorders for FRRS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FRRS1 Gene including...

Search for FRRS1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FRRS1 Gene

Relevant External Links for FRRS1

Genetic Association Database (GAD)
FRRS1
Human Genome Epidemiology (HuGE) Navigator
FRRS1
genes like me logo Genes that share disorders with FRRS1: view

No data available for UniProtKB/Swiss-Prot for FRRS1 Gene

Publications for FRRS1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PMID: 23218918) Sprooten E. … McIntosh A.M. (Psychiatry Res 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. Cytochrome b561 protein family: expanding roles and versatile transmembrane electron transfer abilities as predicted by a new classification system and protein sequence motif analyses. (PMID: 16169296) Tsubaki M. … Nakanishi N. (Biochim. Biophys. Acta 2005) 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for FRRS1 Gene

Sources for FRRS1 Gene

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