FRRS1 Gene
protein-coding GIFtS: 44
GCID: GC01M100174
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ferric-chelate reductase 1(Previous name: stromal cell derived factor receptor 2 homolog (mouse)...)
(Previous symbol: SDFR2)
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Aliases
for FRRS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ferric-Chelate Reductase 11 2 | | SDR-22 3 | | SDR21 2 3 5 | | Stromal Cell Derived Factor Receptor 2 Homolog (Mouse)1 | | SDFR21 2 3 | | Stromal Cell Derived Factor Receptor 2 Homolog2 | | Stromal Cell-Derived Receptor 22 3 | | EC 1.-.-.-3 |
Export aliases for FRRS1 gene to outside databasesPrevious GC identifers: GC01M099946 GC01M098296 |
Summaries
for FRRS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FRRS1:
Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before itstransport from the endosome to the cytoplasm (Vargas et al., 2003 (PubMed 14499595)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FRRS1_HUMAN, Q6ZNA5Function: Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm (Bysimilarity)
|
Genomic Views
for FRRS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FRRS1 gene promoter:
c-Fos STAT5B AP-1 AML1a GATA-1 Evi-1 c-Ets-1 FOXJ2 (long isoform) c-Jun FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FRRS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRRS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p21.2 Ensembl cytogenetic band: 1p21.2 HGNC cytogenetic band: 1p21.3FRRS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M100174: view genomic region
(about GC identifiers)
Start:
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100,174,259 bp from pter |
End:
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100,232,187 bp from pter |
Size:
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57,929 bases |
Orientation:
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minus strand |
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Proteins
for FRRS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FRRS1_HUMAN, Q6ZNA5 (See
protein sequence)Recommended Name: Ferric-chelate reductase 1 Size: 592 amino acids; 66114 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A6NLN7Alternative splicing: 2 isoforms: Q6ZNA5-1 Q6ZNA5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FRRS1: NX_Q6ZNA5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZNA5
FRRS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001013682.2
ENSEMBL proteins: ENSP00000287474 ENSP00000393884
Human Recombinant Protein Products for FRRS1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FRRS1 for ontologies About GeneDecksing
FRRS1 Antibody Products:
Assay Products for FRRS1: |
Protein
Domains /
Families
for FRRS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FRRS1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZNA5ProtoNet protein and cluster: Q6ZNA5 UniProtKB/Swiss-Prot: FRRS1_HUMAN, Q6ZNA5Similarity: Belongs to the FRRS1 familySimilarity: Contains 1 cytochrome b561 domainSimilarity: Contains 1 DOMON domainSimilarity: Contains 1 reelin domain |
Function
for FRRS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FRRS1_HUMAN, Q6ZNA5Function: Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm (Bysimilarity) Enzyme Number (IUBMB): EC 1.-.-.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FRRS1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRRS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRRS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FRRS1 (NM_001013660) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FRRS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRRS1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRRS1 |
|
Pathways & Interactions
for FRRS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FRRS1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0022900 | electron transport chain |
IEA | -- |
FRRS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FRRS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FRRS1
1 HMDB Compound for FRRS1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
Search CenterWatch for drugs/clinical trials and news about FRRS1
|
Transcripts
for FRRS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FRRS1 gene: NM_001013660.2 Unigene Cluster for FRRS1: Ferric-chelate reductase 1 Hs.454779 [show with all ESTs]Unigene Representative Sequence: AK1313025 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287474 ENST00000489209 ENST00000492943 ENST00000370176 ENST00000414213(uc001dsh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRRS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRRS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FRRS1 (NM_001013660) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FRRS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRRS1 |
Additional cDNA sequence: AK131302.1 BC029438.2 4 DOTS entries: DT.91712936 DT.121408618 DT.91831481 DT.40196035 6 AceView cDNA sequences: BC029438 BG434509 N26892 AK131302 N39774 AI151193
GeneLoc Exon Structure
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Expression
for FRRS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FRRS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAGATTTT
About this image
See FRRS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FRRS1
SOURCE GeneReport for Unigene cluster: Hs.454779
SABiosciences Custom PCR Arrays for FRRS1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRRS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRRS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRRS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRRS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRRS1 |
Orthologs
for FRRS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FRRS1 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for FRRS1 (if available)
TreeFam Gene Tree for FRRS1 (if available) |
Paralogs
for FRRS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FRRS1 gene
- FRRS1L2
FRRS1 for paralogs About GeneDecksing
|
Genomic Variants
for FRRS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FRRS1 (100174259 - 100232187 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FRRS1
2 CNVs: 69191 69192 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRRS1 |
|
Disorders
/ Diseases
for FRRS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FRRS1 for disorders About GeneDecksing
OMIM gene information: 611578
OMIM disorders: --
4  diseases for FRRS1: About MalaCardsmultidrug-resistant tuberculosis pulmonary tuberculosis pneumonia tuberculosis
1 disease from the University of Copenhagen DISEASES database for FRRS1:multidrug-resistant tuberculosis Human Genome Epidemiology (HuGE) Navigator: FRRS1 (1 document)
Export disorders for FRRS1 gene to outside databases
|
Publications
for FRRS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FRRS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FRRS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Cytochrome b561 protein family: expanding roles and versatile transmembrane electron transfer abilities as predicted by a new classification system and protein sequence motif analyses. (PubMed id 16169296)2 Tsubaki M.... Nakanishi N. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. (PubMed id 14499595)1 Vargas J.D....Ponting C.P. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FRRS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FRRS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FRRS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FRRS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FRRS1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FRRS1 gene:
Search GeneIP for patents involving FRRS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FRRS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FRRS1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRRS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRRS1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FRRS1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRRS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRRS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FRRS1 | | OriGene Custom Protein Services for FRRS1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FRRS1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRRS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRRS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRRS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRRS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRRS1 |
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| | | | Search Tocris compounds for FRRS1 |
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 | | | FRRS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRRS1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FRRS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRRS1 |
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