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Aliases for FRRS1 Gene

Aliases for FRRS1 Gene

  • Ferric Chelate Reductase 1 2 3 5
  • Stromal Cell-Derived Receptor 2 3 4
  • Ferric-Chelate Reductase 1 2 3
  • SDFR2 3 4
  • SDR-2 3 4
  • SDR2 3 4
  • Stromal Cell Derived Factor Receptor 2 Homolog (Mouse) 2
  • Stromal Cell Derived Factor Receptor 2 Homolog 3
  • EC 1.-.-.- 4

External Ids for FRRS1 Gene

Previous HGNC Symbols for FRRS1 Gene

  • SDFR2

Previous GeneCards Identifiers for FRRS1 Gene

  • GC01M099946
  • GC01M100174
  • GC01M098296

Summaries for FRRS1 Gene

Entrez Gene Summary for FRRS1 Gene

  • Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FRRS1 Gene

FRRS1 (Ferric Chelate Reductase 1) is a Protein Coding gene. Diseases associated with FRRS1 include Multidrug-Resistant Tuberculosis. Gene Ontology (GO) annotations related to this gene include ferric-chelate reductase activity. An important paralog of this gene is FRRS1L.

UniProtKB/Swiss-Prot for FRRS1 Gene

  • Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.

Additional gene information for FRRS1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRRS1 Gene

Genomics for FRRS1 Gene

GeneHancer (GH) Regulatory Elements for FRRS1 Gene

Promoters and enhancers for FRRS1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I099765 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 561.5 +0.2 204 1.7 PKNOX1 SMAD1 ARID4B SIN3A ZNF2 BRCA1 YY1 TCF12 POLR2B E2F8 FRRS1 SASS6 TRMT13 HMGB3P10
GH01I100248 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -483.0 -483013 2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000230287 DBT RTCA FRRS1
GH01I099757 Enhancer 1.1 Ensembl ENCODE 12.1 +8.0 7972 2.7 FOXA2 MLX RARA YY1 CHAMP1 ZNF280A ATF7 IKZF2 CREM THAP11 FRRS1 SASS6 HMGB3P10
GH01I099727 Enhancer 0.6 Ensembl 21.4 +38.1 38131 1.4 CTCF JUN MAFG RAD21 FOSL1 ZNF316 POLR2A GLIS1 ZNF629 IKZF1 FRRS1 LRRC39 HMGB3P10
GH01I100046 Enhancer 1.3 FANTOM5 Ensembl ENCODE 9.7 -281.8 -281819 4.5 HDAC1 PKNOX1 FOXA2 ZNF133 TCF12 POLR3A ATF7 IKZF2 RUNX3 ZNF202 SASS6 LRRC39 HNRNPA1P68 TRMT13 RTCA FRRS1 MFSD14A ENSG00000241073 ENSG00000283761
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FRRS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FRRS1 gene promoter:

Genomic Locations for FRRS1 Gene

Genomic Locations for FRRS1 Gene
58,000 bases
Minus strand

Genomic View for FRRS1 Gene

Genes around FRRS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRRS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRRS1 Gene

Proteins for FRRS1 Gene

  • Protein details for FRRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ferric-chelate reductase 1
    Protein Accession:
    Secondary Accessions:
    • A6NLN7

    Protein attributes for FRRS1 Gene

    592 amino acids
    Molecular mass:
    66114 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRRS1 Gene


neXtProt entry for FRRS1 Gene

Post-translational modifications for FRRS1 Gene

  • Glycosylation at posLast=138138, posLast=308308, and isoforms=2321

Other Protein References for FRRS1 Gene

No data available for DME Specific Peptides for FRRS1 Gene

Domains & Families for FRRS1 Gene

Gene Families for FRRS1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FRRS1 Gene

Suggested Antigen Peptide Sequences for FRRS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FRRS1 family.
  • Belongs to the FRRS1 family.
genes like me logo Genes that share domains with FRRS1: view

Function for FRRS1 Gene

Molecular function for FRRS1 Gene

UniProtKB/Swiss-Prot Function:
Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.

Enzyme Numbers (IUBMB) for FRRS1 Gene

Gene Ontology (GO) - Molecular Function for FRRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000293 ferric-chelate reductase activity ISS 14499595
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FRRS1: view
genes like me logo Genes that share phenotypes with FRRS1: view

Animal Models for FRRS1 Gene

MGI Knock Outs for FRRS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRRS1 Gene

Localization for FRRS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRRS1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRRS1 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for FRRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FRRS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FRRS1 Gene

Pathways & Interactions for FRRS1 Gene

SuperPathways for FRRS1 Gene

No Data Available

Interacting Proteins for FRRS1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000287474 Q6ZNA5-FRRS1_HUMAN for FRRS1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FRRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FRRS1: view

No data available for Pathways by source and SIGNOR curated interactions for FRRS1 Gene

Drugs & Compounds for FRRS1 Gene

(1) Drugs for FRRS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with FRRS1: view

Transcripts for FRRS1 Gene

mRNA/cDNA for FRRS1 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRRS1 Gene

Ferric-chelate reductase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRRS1 Gene

No ASD Table

Relevant External Links for FRRS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRRS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRRS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRRS1 Gene

This gene is overexpressed in Liver (x5.4) and Esophagus - Mucosa (x4.5).

Protein differential expression in normal tissues from HIPED for FRRS1 Gene

This gene is overexpressed in Plasma (20.4), Urine (14.2), Oral epithelium (8.5), Gallbladder (7.7), Testis (6.3), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FRRS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FRRS1 Gene:


SOURCE GeneReport for Unigene cluster for FRRS1 Gene:

genes like me logo Genes that share expression patterns with FRRS1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRRS1 Gene

Orthologs for FRRS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRRS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FRRS1 33 34
  • 99.41 (n)
(Canis familiaris)
Mammalia FRRS1 33 34
  • 87.32 (n)
(Bos Taurus)
Mammalia FRRS1 33 34
  • 86.77 (n)
(Mus musculus)
Mammalia Frrs1 33 16 34
  • 79.51 (n)
(Rattus norvegicus)
Mammalia Frrs1 33
  • 78.15 (n)
(Ornithorhynchus anatinus)
Mammalia FRRS1 34
  • 68 (a)
(Monodelphis domestica)
Mammalia FRRS1 34
  • 64 (a)
(Gallus gallus)
Aves FRRS1 33 34
  • 68.03 (n)
(Anolis carolinensis)
Reptilia FRRS1 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497064 33
  • 64.41 (n)
Str.14076 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25809 33
(Danio rerio)
Actinopterygii frrs1a 33 34 34
  • 54.25 (n)
FRRS1 (5 of 5) 34
  • 42 (a)
FRRS1 (2 of 5) 34
  • 29 (a)
FRRS1 (1 of 5) 34
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005170 33
  • 42.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8399 33
  • 42.12 (n)
CG14515 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea C05D12.1 33
  • 42.66 (n)
M03A1.3 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
Species where no ortholog for FRRS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRRS1 Gene

Gene Tree for FRRS1 (if available)
Gene Tree for FRRS1 (if available)

Paralogs for FRRS1 Gene

Paralogs for FRRS1 Gene

genes like me logo Genes that share paralogs with FRRS1: view

Variants for FRRS1 Gene

Sequence variations from dbSNP and Humsavar for FRRS1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000050906 -- 99,743,115(-) T/A/C intron_variant
rs1000106892 -- 99,749,524(-) T/C intron_variant
rs1000130434 -- 99,752,609(-) T/C intron_variant
rs1000151011 -- 99,712,339(-) T/C intron_variant
rs1000152920 -- 99,756,700(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FRRS1 Gene

Variant ID Type Subtype PubMed ID
dgv64e212 CNV loss 25503493
esv24594 CNV loss 19812545
esv3383247 CNV insertion 20981092
esv3586928 CNV loss 21293372
nsv1002853 CNV gain 25217958
nsv526047 CNV gain 19592680
nsv998891 CNV loss 25217958

Variation tolerance for FRRS1 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FRRS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRRS1 Gene

Disorders for FRRS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FRRS1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
multidrug-resistant tuberculosis
  • tuberculosis multidrug-resistant
- elite association - COSMIC cancer census association via MalaCards
Search FRRS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FRRS1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FRRS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FRRS1 Gene

Publications for FRRS1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PMID: 23218918) Sprooten E … McIntosh AM (Psychiatry research 2013) 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  4. Cytochrome b561 protein family: expanding roles and versatile transmembrane electron transfer abilities as predicted by a new classification system and protein sequence motif analyses. (PMID: 16169296) Tsubaki M … Nakanishi N (Biochimica et biophysica acta 2005) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for FRRS1 Gene

Sources for FRRS1 Gene

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