Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FRRS1 Gene

protein-coding   GIFtS: 45
GCID: GC01M100174

Ferric-Chelate Reductase 1

(Previous name: stromal cell derived factor receptor 2 homolog (mouse))
(Previous symbol: SDFR2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ferric-Chelate Reductase 11 2     SDR-22 3
SDFR21 2 3     Stromal Cell Derived Factor Receptor 2 Homolog (Mouse)1
SDR22 3 5     Stromal Cell Derived Factor Receptor 2 Homolog2
Stromal Cell-Derived Receptor 22 3     EC 1.-.-.-3

External Ids:    HGNC: 276221   Entrez Gene: 3910592   Ensembl: ENSG000001568697   OMIM: 6115785   UniProtKB: Q6ZNA53   

Export aliases for FRRS1 gene to outside databases

Previous GC identifers: GC01M099946 GC01M098296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FRRS1 Gene:
Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before
its transport from the endosome to the cytoplasm (Vargas et al., 2003 (PubMed 14499595)).(supplied by OMIM, Mar
2008)

GeneCards Summary for FRRS1 Gene:
FRRS1 (ferric-chelate reductase 1) is a protein-coding gene. Diseases associated with FRRS1 include multidrug-resistant tuberculosis, and tuberculosis. GO annotations related to this gene include ferric-chelate reductase activity.

UniProtKB/Swiss-Prot: FRRS1_HUMAN, Q6ZNA5
Function: Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the
cytoplasm (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRRS1 gene promoter:
         c-Fos   STAT5B   AP-1   AML1a   GATA-1   Evi-1   c-Ets-1   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRRS1 promoter sequence
   Search Chromatin IP Primers for FRRS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRRS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21.2   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p21.3

FRRS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRRS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M100174:  view genomic region     (about GC identifiers)

Start:
100,174,259 bp from pter      End:
100,232,187 bp from pter
Size:
57,929 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FRRS1_HUMAN, Q6ZNA5 (See protein sequence)
Recommended Name: Ferric-chelate reductase 1  
Size: 592 amino acids; 66114 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Secondary accessions: A6NLN7
Alternative splicing: 2 isoforms:  Q6ZNA5-1   Q6ZNA5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FRRS1: NX_Q6ZNA5

Explore proteomics data for FRRS1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn138, Asn308, Asn321

  • See FRRS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001013682.2  
    ENSEMBL proteins: 
     ENSP00000287474   ENSP00000393884  

    FRRS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FRRS1
    GenScript Custom Purified and Recombinant Proteins Services for FRRS1
    Novus Biologicals FRRS1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FRRS1

    FRRS1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FRRS1
    Novus Biologicals FRRS1 Antibody
    Abcam antibodies for FRRS1
    Cloud-Clone Corp. Antibodies for FRRS1
    Search ThermoFisher Antibodies for FRRS1
    Search LSBio for Antibodies for FRRS1

    FRRS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FRRS1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FRRS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FRRS1
    Cloud-Clone Corp. CLIAs for FRRS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR005018 DOMON_domain
     IPR006593 Cyt_b561/ferric_Rdtase_TM
     IPR002861 Reeler_dom

    Graphical View of Domain Structure for InterPro Entry Q6ZNA5

    ProtoNet protein and cluster: Q6ZNA5

    UniProtKB/Swiss-Prot: FRRS1_HUMAN, Q6ZNA5
    Similarity: Belongs to the FRRS1 family
    Similarity: Contains 1 cytochrome b561 domain
    Similarity: Contains 1 DOMON domain
    Similarity: Contains 1 reelin domain


    FRRS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRRS1_HUMAN, Q6ZNA5
    Function: Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the
    cytoplasm (By similarity)

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000293ferric-chelate reductase activity ISS14499595
    GO:0046872metal ion binding IEA--
         
    FRRS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Frrs1):
     mortality/aging 

    FRRS1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FRRS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FRRS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FRRS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FRRS1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FRRS1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FRRS1
    SwitchGear 3'UTR luciferase reporter plasmidFRRS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FRRS1
    Predesigned siRNA for gene silencing in human, mouse, rat FRRS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FRRS1

    Clone
    Products:
         
    OriGene clones in human, mouse for FRRS1 (see all 5)
    OriGene ORF clones in mouse, rat for FRRS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FRRS1 (NM_001013660)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRRS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRRS1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FRRS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for FRRS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRRS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FRRS1_HUMAN, Q6ZNA5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    FRRS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FRRS1
    Interactions:

        Search GeneGlobe Interaction Network for FRRS1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FRRS1

    1 HMDB Compound for FRRS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FRRS1 gene: 
    NM_001013660.2  

    Unigene Cluster for FRRS1:

    Ferric-chelate reductase 1
    Hs.454779  [show with all ESTs]
    Unigene Representative Sequence: AK131302
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287474 ENST00000489209 ENST00000492943 ENST00000370176 ENST00000414213(uc001dsh.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FRRS1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FRRS1
    SwitchGear 3'UTR luciferase reporter plasmidFRRS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FRRS1
    Predesigned siRNA for gene silencing in human, mouse, rat FRRS1
    Clone
    Products:
         
    OriGene clones in human, mouse for FRRS1 (see all 5)
    OriGene ORF clones in mouse, rat for FRRS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FRRS1 (NM_001013660)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRRS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRRS1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FRRS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRRS1
      QuantiTect SYBR Green Assays in human, mouse, rat FRRS1
      QuantiFast Probe-based Assays in human, mouse, rat FRRS1

    Additional mRNA sequence: 

    AK131302.1 BC029438.2 

    4 DOTS entries:

    DT.91712936  DT.121408618  DT.91831481  DT.40196035 

    6 AceView cDNA sequences:

    BC029438 AK131302 BG434509 N26892 AI151193 N39774 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FRRS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGATTTT
    FRRS1 Expression
    About this image


    FRRS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    FRRS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRRS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.454779
        Custom PCR Arrays for FRRS1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FRRS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRRS1
    QuantiTect SYBR Green Assays in human, mouse, rat FRRS1
    QuantiFast Probe-based Assays in human, mouse, rat FRRS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRRS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FRRS1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frrs11 , 5 ferric-chelate reductase 11, 5 79.51(n)1
    77.04(a)1
      3 (50.49 cM)5
    203211  NM_001113478.11  NP_001106950.11 
     1168782275 
    chicken
    (Gallus gallus)
    Aves FRRS11 ferric-chelate reductase 1 68.03(n)
    60.78(a)
      429082  XM_004936557.1  XP_004936614.1 
    lizard
    (Anolis carolinensis)
    Reptilia FRRS16
    ferric-chelate reductase 1
    51(a)
    1 ↔ 1
    4(93298824-93333916)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.258092 Xenopus laevis transcribed sequence with weak similarity more 78.12(n)    CF285881.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005367071 putative ferric-chelate reductase 1-like 54.25(n)
    46.68(a)
      100536707  XM_003197848.2  XP_003197896.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83991 CG8399 42.12(n)
    32.25(a)
      36768  NM_137235.2  NP_611079.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C05D12.11 C05D12.1 42.66(n)
    30.06(a)
      174740  NM_064031.5  NP_496432.2 


    ENSEMBL Gene Tree for FRRS1 (if available)
    TreeFam Gene Tree for FRRS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FRRS1 (see all 1314)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs603111611,2
    C--98342247(+) AGAGA-/GAAATGC 1 -- int11Minor allele frequency- GA:0.00NA 2
    rs1421763661,2
    --100173796(+) ACAGAC/TCATTC 1 -- ds50010--------
    rs111663041,2
    C,F,A--100173931(+) CAGGCA/GGATCA 1 -- ds50013Minor allele frequency- G:0.33NA WA 6
    rs1879135061,2
    --100173997(+) AATATA/TAAAAA 1 -- ds50010--------
    rs49080061,2
    C--100174086(+) GAGGCG/AGAGCT 1 -- ds50012Minor allele frequency- A:0.00NA 4
    rs75517431,2
    C,A--100174183(+) aaaaaA/Tatata 1 -- ds50010--------
    rs111663051,2
    A--100174210(+) TATATA/GTATAT 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs111663061,2
    C,A--100174218(+) TATATA/CTCGTA 1 -- ds50010--------
    rs1448244841,2
    C--100174231(+) ATATC-/TCTT  
            
    TATTA
    1 -- ds50010--------
    rs2019926161,2
    C--100174234(-) TAATAA/GANNNN 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FRRS1 (100174259 - 100232187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FRRS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24594CNV Loss19812545
    nsv526047CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FRRS1
    DNA2.0 Custom Variant and Variant Library Synthesis for FRRS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611578    OMIM disorders: --

    5 diseases for FRRS1:    
    About MalaCards
    multidrug-resistant tuberculosis    tuberculosis    pulmonary tuberculosis    bipolar disorder
    malaria

    1 disease from the University of Copenhagen DISEASES database for FRRS1:
    multidrug-resistant tuberculosis

    FRRS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FRRS1
    Human Genome Epidemiology (HuGE) Navigator: FRRS1 (1 document)

    Export disorders for FRRS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FRRS1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FRRS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PubMed id 23218918)1 Sprooten E....McIntosh A.M. (Psychiatry Res 2013)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Cytochrome b561 protein family: expanding roles and versatile transmembrane electron transfer abilities as predicted by a new classification system and protein sequence motif analyses. (PubMed id 16169296)2 Tsubaki M.... Nakanishi N. (Biochim. Biophys. Acta 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. (PubMed id 14499595)1 Vargas J.D....Ponting C.P. (Biochim. Biophys. Acta 2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 391059 HGNC: 27622 AceView: LOC391059 Ensembl:ENSG00000156869 euGenes: HUgn391059
    ECgene: FRRS1 H-InvDB: FRRS1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FRRS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FRRS1 gene:
    Search GeneIP for patents involving FRRS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FRRS1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FRRS1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FRRS1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FRRS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FRRS1   OriGene Custom Protein Services for FRRS1  

     
     
     Block miRNA regulation of human, mouse, rat FRRS1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FRRS1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRRS1 Predesigned siRNA for gene silencing in human, mouse, rat FRRS1
     QuantiFast Probe-based Assays in human, mouse, rat FRRS1 QuantiTect SYBR Green Assays in human, mouse, rat FRRS1
     Custom PCR Arrays for FRRS1 Search Chromatin IP Primers for FRRS1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRRS1  Search GeneGlobe Interaction Network for FRRS1
     Regulatory tfbs in FRRS1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FRRS1 GenScript cDNA clones with any tag delivered in your preferred vector for FRRS1
     GenScript Custom Assay Services for FRRS1 GenScript Custom overexpressing Cell Line Services for FRRS1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FRRS1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FRRS1 antibodies
     FRRS1 proteins
     Antibodies for FRRS1
     See all of Abcam's Antibodies, Kits and Proteins for FRRS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FRRS1
     Antibodies for FRRS1
     ELISAs for FRRS1
     CLIAs for FRRS1



     Browse ESI BIO Cell Lines and PureStem Progenitors for FRRS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRRS1
     SwitchGear 3'UTR luciferase reporter plasmids for FRRS1
     SwitchGear Promoter luciferase reporter plasmids for FRRS1
     Search ThermoFisher Antibodies for FRRS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRRS1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FRRS1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FRRS1
     Search LSBio for Antibodies for FRRS1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FRRS1 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4