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FRMPD4 Gene

protein-coding   GIFtS: 50
GCID: GC0XP012066

FERM And PDZ Domain Containing 4

(Previous name: PDZ domain containing 10)
(Previous symbols: PDZK10, PDZD10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FERM And PDZ Domain Containing 41 2     KIAA03163 5
PDZD101 2 3     PDZ Domain Containing 101
PDZK101 2 3     FERM And PDZ Domain-Containing Protein 42
Preso2 3     PSD-95-Interacting FERM And PDZ Domain Protein2
PDZ Domain-Containing Protein 102 3     PRESO5
PSD-95-Interacting Regulator Of Spine Morphogenesis2 3     

External Ids:    HGNC: 290071   Entrez Gene: 97582   Ensembl: ENSG000001699337   OMIM: 3008385   UniProtKB: Q14CM03   

Export aliases for FRMPD4 gene to outside databases

Previous GC identifer: GC0XP009927


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FRMPD4 Gene:
This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins
(such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is
required for the maintenance of excitatory synaptic transmission. (provided by RefSeq, Jan 2010)

GeneCards Summary for FRMPD4 Gene:
FRMPD4 (FERM and PDZ domain containing 4) is a protein-coding gene. Diseases associated with FRMPD4 include parkinson's disease, and endotheliitis. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is FRMPD1.

UniProtKB/Swiss-Prot: FRPD4_HUMAN, Q14CM0
Function: Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of
excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRMPD4 gene promoter:
         Nkx3-1   Nkx3-1 v4   FOXD3   Lmo2   Nkx3-1 v1   Tal-1beta   E47   Nkx3-1 v2   FOXC1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRMPD4 promoter sequence
   Search Chromatin IP Primers for FRMPD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRMPD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.31

FRMPD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRMPD4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP012066:  view genomic region     (about GC identifiers)

Start:
12,156,585 bp from pter      End:
12,742,642 bp from pter
Size:
586,058 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FRPD4_HUMAN, Q14CM0 (See protein sequence)
Recommended Name: FERM and PDZ domain-containing protein 4  
Size: 1322 amino acids; 144379 Da
Subunit: Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7;
the interaction is mediated by the PDZ domain
Secondary accessions: A8K0X9 O15032

Explore the universe of human proteins at neXtProt for FRMPD4: NX_Q14CM0

Explore proteomics data for FRMPD4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FRMPD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055543.2  
    ENSEMBL proteins: 
     ENSP00000370057  

    FRMPD4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for FRMPD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR019748 FERM_central
     IPR014352 FERM/acyl-CoA-bd_prot_3-hlx
     IPR001478 PDZ
     IPR019749 Band_41_domain
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q14CM0

    ProtoNet protein and cluster: Q14CM0

    1 Blocks protein domain: IPB000299 Band 4.1 domain

    UniProtKB/Swiss-Prot: FRPD4_HUMAN, Q14CM0
    Domain: The FERM domain mediates the interaction with phosphatidylinositol 4,5-bisphosphate
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 WW domain


    FRMPD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRPD4_HUMAN, Q14CM0
    Function: Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of
    excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19118189
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IDA19118189
         
    FRMPD4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Frmpd4):
     behavior/neurological  integument  nervous system 

    FRMPD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Frmpd4tm1.1Pfw for FRMPD4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FRMPD4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FRMPD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FRMPD4

    miRNA
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    miRTarBase miRNAs that target FRMPD4:
    hsa-mir-185-5p (MIRT045327)

    Block miRNA regulation of human, mouse, rat FRMPD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRMPD4 (see all 169):
    hsa-miR-134 hsa-miR-138-2* hsa-miR-519a hsa-miR-877* hsa-miR-1273d hsa-miR-149 hsa-miR-3649 hsa-miR-1231
    SwitchGear 3'UTR luciferase reporter plasmidFRMPD4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FRMPD4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: FRMPD4 (NM_014728)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMPD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FRPD4_HUMAN, Q14CM0: Cell projection, dendritic spine
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton IEA--
    GO:0043197dendritic spine IDA19118189

    FRMPD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FRMPD4
    Interactions:

        Search GeneGlobe Interaction Network for FRMPD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FRMPD4 (Q14CM02, 3 ENSP000003700574) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    STK36Q9NRP73, ENSP000002957094I2D: score=2 STRING: ENSP00000295709
    FAM109BQ6ICB43I2D: score=4 
    RAP1BP612243I2D: score=4 
    NCAM2O153943I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051835positive regulation of synapse structural plasticity IMP19118189

    FRMPD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FRMPD4 (FRPD4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FRMPD4 gene: 
    NM_014728.3  

    Unigene Cluster for FRMPD4:

    FERM and PDZ domain containing 4
    Hs.657507  [show with all ESTs]
    Unigene Representative Sequence: NM_014728
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380682(uc004cuz.2 uc011mij.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FRMPD4 (see all 169):
    hsa-miR-134 hsa-miR-138-2* hsa-miR-519a hsa-miR-877* hsa-miR-1273d hsa-miR-149 hsa-miR-3649 hsa-miR-1231
    SwitchGear 3'UTR luciferase reporter plasmidFRMPD4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FRMPD4 (NM_014728)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRMPD4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FRMPD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRMPD4
      QuantiTect SYBR Green Assays in human, mouse, rat FRMPD4
      QuantiFast Probe-based Assays in human, mouse, rat FRMPD4

    Additional mRNA sequence: 

    AB002314.3 AK289694.1 BC113700.1 BC113702.1 BC143746.1 

    4 DOTS entries:

    DT.405953  DT.442845  DT.100691297  DT.40190661 

    17 AceView cDNA sequences:

    AA947461 AB002314 CA413987 AA772074 AA838814 AW139139 AA984414 BG149690 
    Z41089 BI791494 BQ717889 BI712905 BF433737 AW297087 Z45374 BG149207 
    AA724666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FRMPD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGAGCAAA
    FRMPD4 Expression
    About this image

    FRMPD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRMPD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657507
        Custom PCR Arrays for FRMPD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMPD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FRMPD4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frmpd41 , 5 FERM and PDZ domain containing 41, 5 87.79(n)1
    90.75(a)1
      X (78.36 cM)5
    3336051  NM_001033330.21  NP_001028502.11 
     1674713095 
    chicken
    (Gallus gallus)
    Aves FRMPD41 FERM and PDZ domain containing 4 77.29(n)
    80.72(a)
      418640  XM_416838.4  XP_416838.4 
    lizard
    (Anolis carolinensis)
    Reptilia FRMPD46
    FERM and PDZ domain containing 4
    76(a)
    1 ↔ 1
    3(119678574-119962244)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia frmpd41 FERM and PDZ domain containing 4 68.16(n)
    70.26(a)
      100494902  XM_002933807.2  XP_002933853.2 
    zebrafish
    (Danio rerio)
    Actinopterygii frmpd41 FERM and PDZ domain containing 4 63.77(n)
    64.39(a)
      403129  XM_003199262.2  XP_003199310.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG427886
    --
    19(a)
    1 → many
    3R(10921679-10957646)
    worm
    (Caenorhabditis elegans)
    Secernentea frm-86
    Protein FRM-8, isoform c (frm-8) mRNA, complete cd...
    23(a)
    1 → many
    III(3200800-3219150) WBGene00001494


    ENSEMBL Gene Tree for FRMPD4 (if available)
    TreeFam Gene Tree for FRMPD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FRMPD4 gene
    FRMPD12  FRMPD32  

    FRMPD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FRMPD4 (see all 8781)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70519201,2
    C,F,H--12069496(+) attggT/Agcata 1 -- us2k14Minor allele frequency- A:0.04NS EA 402
    rs1857999321,2
    --12069500(+) GTGCAC/TACATT 1 -- us2k10--------
    rs1463775981,2
    --12069503(+) CATACA/CTTTGA 1 -- us2k10--------
    rs1905981581,2
    --12069529(+) GGCCAC/TGCAGA 1 -- us2k10--------
    rs1820827381,2
    --12069849(+) TCAGAC/GAAGTA 1 -- us2k10--------
    rs2007338481,2
    C--12069911(+) CACAC-/ATACACA 1 -- us2k10--------
    rs1872314281,2
    --12070203(+) AACTAC/TGTATT 1 -- us2k10--------
    rs1919847931,2
    --12070344(+) TTTAAA/GTATAA 1 -- us2k10--------
    rs1827114871,2
    --12070350(+) TATAAA/CAACAG 1 -- us2k10--------
    rs66391501,2
    C,F,A,H--12070553(+) AGTCTG/TGGGGG 1 -- us2k114Minor allele frequency- T:0.23NS EA NA 1982

    HapMap Linkage Disequilibrium report for FRMPD4 (12156585 - 12406585 bp, first 250kb of FRMPD4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FRMPD4 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675942CNV Deletion23128226
    esv2678043CNV Deletion23128226
    esv2664942CNV Deletion23128226
    esv2565381CNV Deletion19546169
    nsv507945CNV Insertion20534489
    nsv512669CNV Loss21212237
    nsv510525CNV Loss20534489
    nsv515168CNV Loss21397061
    nsv6802CNV Loss18451855
    nsv6803CNV Loss18451855

    Human Gene Mutation Database (HGMD): FRMPD4
    Locus Specific Mutation Databases (LSDB): FRMPD4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FRMPD4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300838    OMIM disorders: --

    2 diseases for FRMPD4:    About MalaCards
    parkinson's disease    endotheliitis


    FRMPD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FRMPD4
    Human Genome Epidemiology (HuGE) Navigator: FRMPD4 (3 documents)

    Export disorders for FRMPD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FRMPD4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with FRMPD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. (PubMed id 19118189)1, 2 Lee H.W.... Kim E. (J. Neurosci. 2008)
    4. Protein phosphatase 1I+ interacting proteins in the human brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (OMICS 2012)
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    7. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    9. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    10. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17052657)4 Fung H.C....Singleton A. (Lancet Neurol 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9758 HGNC: 29007 AceView: PDZK10 Ensembl:ENSG00000169933 euGenes: HUgn9758
    ECgene: FRMPD4 H-InvDB: FRMPD4

    (According to HUGE)
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    HUGE: KIAA0316

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FRMPD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FRMPD4 gene:
    Search GeneIP for patents involving FRMPD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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