Aliases for FRMPD2 Gene
External Ids for FRMPD2 Gene
Previous HGNC Symbols for FRMPD2 Gene
Previous GeneCards Identifiers for FRMPD2 Gene
This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]
GeneCards Summary for FRMPD2 Gene
FRMPD2 (FERM And PDZ Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and 1-phosphatidylinositol binding. An important paralog of this gene is PTPN13.
UniProtKB/Swiss-Prot for FRMPD2 Gene
May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2).