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Aliases for FRMPD1 Gene

Aliases for FRMPD1 Gene

  • FERM And PDZ Domain Containing 1 2 3 5
  • FERM Domain-Containing Protein 2 3 4
  • FRMD2 3 4
  • FERM And PDZ Domain-Containing Protein 1 3
  • KIAA0967 4

External Ids for FRMPD1 Gene

Previous GeneCards Identifiers for FRMPD1 Gene

  • GC09P037642
  • GC09P037643

Summaries for FRMPD1 Gene

GeneCards Summary for FRMPD1 Gene

FRMPD1 (FERM And PDZ Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is FRMPD3.

UniProtKB/Swiss-Prot for FRMPD1 Gene

  • Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMPD1 Gene

Genomics for FRMPD1 Gene

Regulatory Elements for FRMPD1 Gene

Enhancers for FRMPD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G037706 0.7 ENCODE 24.8 +103.5 103505 1.0 ZFP64 ZBTB11 ZNF426 REST ZNF394 ZNF781 ZNF518A ZNF697 ZNF664 ZNF555 FRMPD1 EXOSC3 ENSG00000232454 GC09M037661 RN7SKP171 TRMT10B
GH09G037485 1.3 ENCODE dbSUPER 9.7 -116.2 -116178 3.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 RPL21P83 POLR1E ZBTB5 EXOSC3 FBXO10 ENSG00000234160 TOMM5 ENSG00000256966 FRMPD1 GRHPR
GH09G037692 0.6 ENCODE 20.4 +90.1 90135 1.7 HDGF MCM3 MCM5 TSC22D4 UBTF FOSL1 ZNF316 SMARCA4 MLLT1 EMSY FRMPD1 RPL21P83 GC09M037661 RN7SKP171 TRMT10B
GH09G037564 1 Ensembl ENCODE 10.2 -37.0 -36954 2.4 CBFB CHD1 JUNB YBX1 EBF1 TBX21 CBX5 POLR2A NFYB EED RPL21P83 FRMPD1 POLR1E FBXO10 GC09M037564 PIR31436
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FRMPD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FRMPD1 Gene

37,602,978 bp from pter
37,746,904 bp from pter
143,927 bases
Plus strand

Genomic View for FRMPD1 Gene

Genes around FRMPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMPD1 Gene

Proteins for FRMPD1 Gene

  • Protein details for FRMPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FERM and PDZ domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DZC8
    • B7Z807
    • D3DRQ3
    • Q14C73
    • Q5HY96
    • Q9Y2H3

    Protein attributes for FRMPD1 Gene

    1578 amino acids
    Molecular mass:
    173437 Da
    Quaternary structure:
    • Interacts with GPSM1 (PubMed:18566450). Interacts with GPSM2 (via TPR repeat region) (PubMed:23318951).

    Three dimensional structures from OCA and Proteopedia for FRMPD1 Gene

    Alternative splice isoforms for FRMPD1 Gene


neXtProt entry for FRMPD1 Gene

Post-translational modifications for FRMPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMPD1 Gene

Domains & Families for FRMPD1 Gene

No data available for UniProtKB/Swiss-Prot for FRMPD1 Gene

Function for FRMPD1 Gene

Molecular function for FRMPD1 Gene

UniProtKB/Swiss-Prot Function:
Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.

Gene Ontology (GO) - Molecular Function for FRMPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FRMPD1: view
genes like me logo Genes that share phenotypes with FRMPD1: view

Animal Model Products

CRISPR Products

miRNA for FRMPD1 Gene

miRTarBase miRNAs that target FRMPD1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRMPD1 Gene

Localization for FRMPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMPD1 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Found both in the cytoplasm and associated with the cell membrane. {ECO:0000269 PubMed:18566450}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRMPD1 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FRMPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FRMPD1: view

Pathways & Interactions for FRMPD1 Gene

SuperPathways for FRMPD1 Gene

No Data Available

Interacting Proteins for FRMPD1 Gene

Gene Ontology (GO) - Biological Process for FRMPD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FRMPD1 Gene

Drugs & Compounds for FRMPD1 Gene

No Compound Related Data Available

Transcripts for FRMPD1 Gene

Unigene Clusters for FRMPD1 Gene

FERM and PDZ domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRMPD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -

Relevant External Links for FRMPD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRMPD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRMPD1 Gene

mRNA differential expression in normal tissues according to GTEx for FRMPD1 Gene

This gene is overexpressed in Testis (x11.6) and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Protein differential expression in normal tissues from HIPED for FRMPD1 Gene

This gene is overexpressed in Urine (22.5), Bone marrow stromal cell (17.7), Retina (7.9), and Seminal vesicle (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FRMPD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FRMPD1 Gene:


SOURCE GeneReport for Unigene cluster for FRMPD1 Gene:


Evidence on tissue expression from TISSUES for FRMPD1 Gene

  • Nervous system(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with FRMPD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRMPD1 Gene

Orthologs for FRMPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMPD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FRMPD1 34 35
  • 99.51 (n)
(Canis familiaris)
Mammalia FRMPD1 34 35
  • 87.72 (n)
(Bos Taurus)
Mammalia FRMPD1 34 35
  • 86.43 (n)
(Rattus norvegicus)
Mammalia Frmpd1 34
  • 81.31 (n)
(Mus musculus)
Mammalia Frmpd1 34 16 35
  • 81.3 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
-- 35
  • 51 (a)
(Monodelphis domestica)
Mammalia FRMPD1 35
  • 59 (a)
(Gallus gallus)
Aves FRMPD1 34 35
  • 63.54 (n)
(Anolis carolinensis)
Reptilia FRMPD1 35
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia frmpd1 34
  • 59.34 (n)
(Danio rerio)
Actinopterygii CU638740.4 35
  • 65 (a)
FRMPD1 (6 of 6) 35
  • 48 (a)
BX088718.4 35
  • 47 (a)
FRMPD1 (1 of 6) 35
  • 33 (a)
FRMPD1 (5 of 6) 35
  • 30 (a)
FRMPD1 (3 of 6) 35
  • 19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42788 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea frm-8 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for FRMPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMPD1 Gene

Gene Tree for FRMPD1 (if available)
Gene Tree for FRMPD1 (if available)

Paralogs for FRMPD1 Gene

Paralogs for FRMPD1 Gene

genes like me logo Genes that share paralogs with FRMPD1: view

Variants for FRMPD1 Gene

Sequence variations from dbSNP and Humsavar for FRMPD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_035445 A breast cancer sample
rs1000012590 -- 37,657,287(+) TGCTG(A/C)CTTGT intron-variant
rs1000025185 -- 37,740,330(+) CTACA(A/G)GACCA nc-transcript-variant, reference, missense
rs1000034277 -- 37,686,360(+) ATAAG(A/G)TGGGT intron-variant
rs1000041152 -- 37,613,746(+) CTTAA(A/G)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMPD1 Gene

Variant ID Type Subtype PubMed ID
esv1260484 CNV insertion 17803354
esv3361901 CNV insertion 20981092
esv3380824 CNV insertion 20981092
esv3620413 CNV loss 21293372
esv3891658 CNV gain 25118596
nsv1023950 CNV loss 25217958
nsv1079005 CNV insertion 25765185
nsv1125318 OTHER inversion 24896259
nsv1145824 CNV insertion 26484159
nsv469813 CNV loss 16826518
nsv819610 CNV loss 19587683
nsv831552 CNV gain 17160897

Variation tolerance for FRMPD1 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.89; 94.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRMPD1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMPD1 Gene

Disorders for FRMPD1 Gene

Relevant External Links for FRMPD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRMPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMPD1 Gene

Publications for FRMPD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Structural and biochemical characterization of the interaction between LGN and Frmpd1. (PMID: 23318951) Pan Z. … Wen W. (J. Mol. Biol. 2013) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. (PMID: 18566450) An N. … Lanier S.M. (J. Biol. Chem. 2008) 3 4 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for FRMPD1 Gene

Sources for FRMPD1 Gene

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