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Aliases for FRMPD1 Gene

Aliases for FRMPD1 Gene

  • FERM And PDZ Domain Containing 1 2 3
  • FERM Domain-Containing Protein 2 3 4
  • FRMD2 3 4
  • FERM And PDZ Domain-Containing Protein 1 3
  • KIAA0967 4

External Ids for FRMPD1 Gene

Previous GeneCards Identifiers for FRMPD1 Gene

  • GC09P037642
  • GC09P037643

Summaries for FRMPD1 Gene

GeneCards Summary for FRMPD1 Gene

FRMPD1 (FERM And PDZ Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is FRMPD3.

UniProtKB/Swiss-Prot for FRMPD1 Gene

  • Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMPD1 Gene

Genomics for FRMPD1 Gene

Regulatory Elements for FRMPD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FRMPD1 Gene

Start:
37,651,000 bp from pter
End:
37,746,904 bp from pter
Size:
95,905 bases
Orientation:
Plus strand

Genomic View for FRMPD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRMPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMPD1 Gene

Proteins for FRMPD1 Gene

  • Protein details for FRMPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SYB0-FRPD1_HUMAN
    Recommended name:
    FERM and PDZ domain-containing protein 1
    Protein Accession:
    Q5SYB0
    Secondary Accessions:
    • B4DZC8
    • B7Z807
    • D3DRQ3
    • Q14C73
    • Q5HY96
    • Q9Y2H3

    Protein attributes for FRMPD1 Gene

    Size:
    1578 amino acids
    Molecular mass:
    173437 Da
    Quaternary structure:
    • Interacts with GPSM1.

    Three dimensional structures from OCA and Proteopedia for FRMPD1 Gene

    Alternative splice isoforms for FRMPD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRMPD1 Gene

Proteomics data for FRMPD1 Gene at MOPED

Post-translational modifications for FRMPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRMPD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRMPD1 Gene

Domains for FRMPD1 Gene

Protein Domains for FRMPD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SYB0

UniProtKB/Swiss-Prot:

FRPD1_HUMAN :
  • Q5SYB0
Domain:
  • Contains 1 FERM domain.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with FRMPD1: view

No data available for Gene Families for FRMPD1 Gene

Function for FRMPD1 Gene

Molecular function for FRMPD1 Gene

UniProtKB/Swiss-Prot Function:
Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.

Gene Ontology (GO) - Molecular Function for FRMPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FRMPD1: view

Phenotypes for FRMPD1 Gene

GenomeRNAi human phenotypes for FRMPD1:
genes like me logo Genes that share phenotypes with FRMPD1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRMPD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FRMPD1 Gene

Localization for FRMPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMPD1 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Found both in the cytoplasm and associated with the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRMPD1 Gene COMPARTMENTS Subcellular localization image for FRMPD1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FRMPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FRMPD1: view

Pathways for FRMPD1 Gene

SuperPathways for FRMPD1 Gene

No Data Available

Interacting Proteins for FRMPD1 Gene

Gene Ontology (GO) - Biological Process for FRMPD1 Gene

None

No data available for Pathways by source for FRMPD1 Gene

Transcripts for FRMPD1 Gene

Unigene Clusters for FRMPD1 Gene

FERM and PDZ domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRMPD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRMPD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP2:
SP3:

Relevant External Links for FRMPD1 Gene

GeneLoc Exon Structure for
FRMPD1
ECgene alternative splicing isoforms for
FRMPD1

Expression for FRMPD1 Gene

mRNA expression in normal human tissues for FRMPD1 Gene

mRNA differential expression in normal tissues according to GTEx for FRMPD1 Gene

This gene is overexpressed in Testis (11.6) and Skin - Not Sun Exposed (Suprapubic) (4.0).

Protein differential expression in normal tissues for FRMPD1 Gene

This gene is overexpressed in Urine (22.5), Bone marrow stromal cell (17.7), Retina (7.9), and Seminal vesicle (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FRMPD1 Gene

SOURCE GeneReport for Unigene cluster for FRMPD1 Gene Hs.163990

genes like me logo Genes that share expressions with FRMPD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for FRMPD1 Gene

Orthologs for FRMPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMPD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FRMPD1 35
  • 86.43 (n)
  • 81.9 (a)
FRMPD1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRMPD1 35
  • 87.72 (n)
  • 84.43 (a)
FRMPD1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frmpd1 35
  • 81.3 (n)
  • 78.3 (a)
Frmpd1 16
Frmpd1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FRMPD1 35
  • 99.51 (n)
  • 99.05 (a)
FRMPD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frmpd1 35
  • 81.31 (n)
  • 77.55 (a)
oppossum
(Monodelphis domestica)
Mammalia FRMPD1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves FRMPD1 35
  • 63.54 (n)
  • 57.72 (a)
FRMPD1 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRMPD1 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frmpd1 35
  • 59.34 (n)
  • 57.46 (a)
zebrafish
(Danio rerio)
Actinopterygii BX088718.4 36
  • 47 (a)
OneToMany
CU638740.4 36
  • 65 (a)
OneToMany
FRMPD1 (1 of 6) 36
  • 33 (a)
OneToMany
FRMPD1 (3 of 6) 36
  • 19 (a)
OneToMany
FRMPD1 (5 of 6) 36
  • 30 (a)
OneToMany
FRMPD1 (6 of 6) 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42788 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frm-8 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for FRMPD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMPD1 Gene

ENSEMBL:
Gene Tree for FRMPD1 (if available)
TreeFam:
Gene Tree for FRMPD1 (if available)

Paralogs for FRMPD1 Gene

Paralogs for FRMPD1 Gene

genes like me logo Genes that share paralogs with FRMPD1: view

Variants for FRMPD1 Gene

Sequence variations from dbSNP and Humsavar for FRMPD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs728911 -- 37,678,935(+) GGCCC(C/T)GTGGT intron-variant
rs750693 -- 37,733,928(+) TGTCA(C/T)GTACT intron-variant
rs750694 -- 37,733,980(+) ATTTA(C/T)CACGC intron-variant
rs751746 -- 37,732,755(+) AATGC(C/T)TTGGA intron-variant
rs765067 -- 37,719,104(-) GCTCT(C/T)TTCTC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FRMPD1 Gene

Variant ID Type Subtype PubMed ID
nsv893060 CNV Gain 21882294
nsv469813 CNV Loss 16826518
esv1260484 CNV Insertion 17803354
nsv831552 CNV Gain 17160897
nsv893061 CNV Loss 21882294
nsv819610 CNV Loss 19587683
nsv893062 CNV Gain 21882294

Relevant External Links for FRMPD1 Gene

HapMap Linkage Disequilibrium report
FRMPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMPD1 Gene

Disorders for FRMPD1 Gene

Relevant External Links for FRMPD1

Genetic Association Database (GAD)
FRMPD1
Human Genome Epidemiology (HuGE) Navigator
FRMPD1

No disorders were found for FRMPD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FRMPD1 Gene

Publications for FRMPD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. (PMID: 18566450) An N. … Lanier S.M. (J. Biol. Chem. 2008) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Structural and biochemical characterization of the interaction between LGN and Frmpd1. (PMID: 23318951) Pan Z. … Wen W. (J. Mol. Biol. 2013) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for FRMPD1 Gene

Sources for FRMPD1 Gene

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