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Aliases for FRMPD1 Gene

Aliases for FRMPD1 Gene

  • FERM And PDZ Domain Containing 1 2 3 5
  • FERM Domain-Containing Protein 2 3 4
  • FRMD2 3 4
  • KIAA0967 4

External Ids for FRMPD1 Gene

Previous GeneCards Identifiers for FRMPD1 Gene

  • GC09P037642
  • GC09P037643

Summaries for FRMPD1 Gene

GeneCards Summary for FRMPD1 Gene

FRMPD1 (FERM And PDZ Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is FRMPD3.

UniProtKB/Swiss-Prot for FRMPD1 Gene

  • Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMPD1 Gene

Genomics for FRMPD1 Gene

Regulatory Elements for FRMPD1 Gene

Enhancers for FRMPD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FRMPD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FRMPD1 Gene

37,602,978 bp from pter
37,746,904 bp from pter
143,927 bases
Plus strand

Genomic View for FRMPD1 Gene

Genes around FRMPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMPD1 Gene

Proteins for FRMPD1 Gene

  • Protein details for FRMPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FERM and PDZ domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DZC8
    • B7Z807
    • D3DRQ3
    • Q14C73
    • Q5HY96
    • Q9Y2H3

    Protein attributes for FRMPD1 Gene

    1578 amino acids
    Molecular mass:
    173437 Da
    Quaternary structure:
    • Interacts with GPSM1 (PubMed:18566450). Interacts with GPSM2 (via TPR repeat region) (PubMed:23318951).

    Three dimensional structures from OCA and Proteopedia for FRMPD1 Gene

    Alternative splice isoforms for FRMPD1 Gene


neXtProt entry for FRMPD1 Gene

Proteomics data for FRMPD1 Gene at MOPED

Post-translational modifications for FRMPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRMPD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRMPD1 Gene

Domains & Families for FRMPD1 Gene

Gene Families for FRMPD1 Gene

Protein Domains for FRMPD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FERM domain.
  • Contains 1 FERM domain.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with FRMPD1: view

Function for FRMPD1 Gene

Molecular function for FRMPD1 Gene

UniProtKB/Swiss-Prot Function:
Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.
genes like me logo Genes that share phenotypes with FRMPD1: view

Animal Model Products

miRNA for FRMPD1 Gene

miRTarBase miRNAs that target FRMPD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRMPD1 Gene

Localization for FRMPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMPD1 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Found both in the cytoplasm and associated with the cell membrane. {ECO:0000269 PubMed:18566450}.

Subcellular locations from

Jensen Localization Image for FRMPD1 Gene COMPARTMENTS Subcellular localization image for FRMPD1 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FRMPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FRMPD1: view

Pathways & Interactions for FRMPD1 Gene

SuperPathways for FRMPD1 Gene

No Data Available

Interacting Proteins for FRMPD1 Gene

Gene Ontology (GO) - Biological Process for FRMPD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FRMPD1 Gene

Drugs & Compounds for FRMPD1 Gene

No Compound Related Data Available

Transcripts for FRMPD1 Gene

Unigene Clusters for FRMPD1 Gene

FERM and PDZ domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMPD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -

Relevant External Links for FRMPD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRMPD1 Gene

mRNA expression in normal human tissues for FRMPD1 Gene

mRNA differential expression in normal tissues according to GTEx for FRMPD1 Gene

This gene is overexpressed in Testis (x11.6) and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Protein differential expression in normal tissues from HIPED for FRMPD1 Gene

This gene is overexpressed in Urine (22.5), Bone marrow stromal cell (17.7), Retina (7.9), and Seminal vesicle (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FRMPD1 Gene

SOURCE GeneReport for Unigene cluster for FRMPD1 Gene Hs.163990

genes like me logo Genes that share expression patterns with FRMPD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FRMPD1 Gene

Orthologs for FRMPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMPD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FRMPD1 35
  • 86.43 (n)
  • 81.9 (a)
  • 81 (a)
(Canis familiaris)
Mammalia FRMPD1 35
  • 87.72 (n)
  • 84.43 (a)
  • 84 (a)
(Mus musculus)
Mammalia Frmpd1 35
  • 81.3 (n)
  • 78.3 (a)
Frmpd1 16
Frmpd1 36
  • 78 (a)
(Pan troglodytes)
Mammalia FRMPD1 35
  • 99.51 (n)
  • 99.05 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Frmpd1 35
  • 81.31 (n)
  • 77.55 (a)
(Monodelphis domestica)
Mammalia FRMPD1 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
-- 36
  • 51 (a)
(Gallus gallus)
Aves FRMPD1 35
  • 63.54 (n)
  • 57.72 (a)
  • 44 (a)
(Anolis carolinensis)
Reptilia FRMPD1 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia frmpd1 35
  • 59.34 (n)
  • 57.46 (a)
(Danio rerio)
Actinopterygii BX088718.4 36
  • 47 (a)
CU638740.4 36
  • 65 (a)
FRMPD1 (1 of 6) 36
  • 33 (a)
FRMPD1 (3 of 6) 36
  • 19 (a)
FRMPD1 (5 of 6) 36
  • 30 (a)
FRMPD1 (6 of 6) 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42788 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea frm-8 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for FRMPD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMPD1 Gene

Gene Tree for FRMPD1 (if available)
Gene Tree for FRMPD1 (if available)

Paralogs for FRMPD1 Gene

Paralogs for FRMPD1 Gene

genes like me logo Genes that share paralogs with FRMPD1: view

Variants for FRMPD1 Gene

Sequence variations from dbSNP and Humsavar for FRMPD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3747539 - 37,692,657(+) TGGAG(A/C)CCAGT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2296556 - 37,707,444(-) CCTGG(C/T)GGGCC intron-variant, nc-transcript-variant, reference, missense
rs7031966 - 37,707,463(+) TCAGA(A/C/G)CCTCA intron-variant, nc-transcript-variant, reference, missense
rs1359590 - 37,729,789(-) CCAGG(A/G)CCAGT nc-transcript-variant, reference, missense
rs34233395 - 37,744,568(-) GGTGT(A/C)GTCGG downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FRMPD1 Gene

Variant ID Type Subtype PubMed ID
nsv893060 CNV Gain 21882294
nsv469813 CNV Loss 16826518
esv1260484 CNV Insertion 17803354
nsv831552 CNV Gain 17160897
nsv893061 CNV Loss 21882294
nsv819610 CNV Loss 19587683
nsv893062 CNV Gain 21882294

Variation tolerance for FRMPD1 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.89; 94.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FRMPD1 Gene

Disorders for FRMPD1 Gene

Relevant External Links for FRMPD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRMPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMPD1 Gene

Publications for FRMPD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study. (PMID: 25786224) Johnson E.O. … Kral A.H. (PLoS ONE 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Structural and biochemical characterization of the interaction between LGN and Frmpd1. (PMID: 23318951) Pan Z. … Wen W. (J. Mol. Biol. 2013) 3

Products for FRMPD1 Gene

Sources for FRMPD1 Gene