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Aliases for FRMD8 Gene

Aliases for FRMD8 Gene

  • FERM Domain Containing 8 2 3 5
  • FERM Domain-Containing Protein 8 3
  • FKSG44 3

External Ids for FRMD8 Gene

Previous GeneCards Identifiers for FRMD8 Gene

  • GC11P064911
  • GC11P065154
  • GC11P061480

Summaries for FRMD8 Gene

GeneCards Summary for FRMD8 Gene

FRMD8 (FERM Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is KRIT1.

Additional gene information for FRMD8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD8 Gene

Genomics for FRMD8 Gene

Regulatory Elements for FRMD8 Gene

Enhancers for FRMD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 64.1 +103.5 103514 40 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 34.9 +37.6 37612 18.8 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SF1 LOC105369352 ZFPL1 KAT5 SART1 MUS81 EIF1AD PCNX3 POLA2 SF3B2
GH11H065851 1.4 ENCODE dbSUPER 31.7 +470.9 470915 12.2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC SART1 ENSG00000258297 RBM14 EIF1AD KAT5 POLA2 PCNX3 ZFPL1 SF3B2 SNX32
GH11H065452 1.3 ENCODE dbSUPER 23.6 +68.5 68458 5.2 ATF1 ARNT ARID4B SIN3A TCF12 ZNF143 ATF7 RUNX3 ZHX2 GTF2B NEAT1 FRMD8 ZFPL1 EIF1AD SART1 PCNX3 SLC25A45 MALAT1 SF1 SF3B2
GH11H066369 1.1 ENCODE 24.3 +984.7 984747 4.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B ZNF766 ZNF143 SP3 EIF1AD ENSG00000258297 PCNX3 KDM2A RBM4 RBM14 SART1 RAD9A FRMD8 ENSG00000245156
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FRMD8 on UCSC Golden Path with GeneCards custom track

Promoters for FRMD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040827 330 1001 ATF1 ARID4B SIN3A ZBTB7B ELK1 ZNF143 FOS ATF7 NFYC SMARCB1

Genomic Locations for FRMD8 Gene

Genomic Locations for FRMD8 Gene
chr11:65,386,570-65,413,525
(GRCh38/hg38)
Size:
26,956 bases
Orientation:
Plus strand
chr11:65,154,041-65,180,996
(GRCh37/hg19)

Genomic View for FRMD8 Gene

Genes around FRMD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD8 Gene

Proteins for FRMD8 Gene

  • Protein details for FRMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ67-FRMD8_HUMAN
    Recommended name:
    FERM domain-containing protein 8
    Protein Accession:
    Q9BZ67
    Secondary Accessions:
    • B4E2P1
    • Q86V56
    • Q8NCB5

    Protein attributes for FRMD8 Gene

    Size:
    464 amino acids
    Molecular mass:
    51218 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRMD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRMD8 Gene

Post-translational modifications for FRMD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD8 Gene

Domains & Families for FRMD8 Gene

Gene Families for FRMD8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FRMD8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FRMD8: view

No data available for UniProtKB/Swiss-Prot for FRMD8 Gene

Function for FRMD8 Gene

Phenotypes From GWAS Catalog for FRMD8 Gene

Gene Ontology (GO) - Molecular Function for FRMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FRMD8: view
genes like me logo Genes that share phenotypes with FRMD8: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRMD8 Gene

Localization for FRMD8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRMD8 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FRMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FRMD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FRMD8 Gene

Pathways & Interactions for FRMD8 Gene

SuperPathways for FRMD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FRMD8 Gene

Drugs & Compounds for FRMD8 Gene

No Compound Related Data Available

Transcripts for FRMD8 Gene

Unigene Clusters for FRMD8 Gene

FERM domain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD8 Gene

No ASD Table

Relevant External Links for FRMD8 Gene

GeneLoc Exon Structure for
FRMD8
ECgene alternative splicing isoforms for
FRMD8

Expression for FRMD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRMD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FRMD8 Gene

This gene is overexpressed in Serum (31.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FRMD8 Gene



Protein tissue co-expression partners for FRMD8 Gene

NURSA nuclear receptor signaling pathways regulating expression of FRMD8 Gene:

FRMD8

SOURCE GeneReport for Unigene cluster for FRMD8 Gene:

Hs.578433

Evidence on tissue expression from TISSUES for FRMD8 Gene

  • Liver(4.5)
  • Intestine(4.4)
  • Nervous system(2.9)
  • Heart(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FRMD8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRMD8 Gene

Orthologs for FRMD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRMD8 33
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia FRMD8 33 34
  • 88.46 (n)
dog
(Canis familiaris)
Mammalia FRMD8 33 34
  • 87.04 (n)
mouse
(Mus musculus)
Mammalia Frmd8 33 16 34
  • 84.59 (n)
rat
(Rattus norvegicus)
Mammalia Frmd8 33
  • 84.48 (n)
oppossum
(Monodelphis domestica)
Mammalia FRMD8 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRMD8 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRMD8 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd8 33
  • 60.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53754 33
zebrafish
(Danio rerio)
Actinopterygii frmd8 33 34
  • 59.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002678 33
  • 49.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bili 33 34
  • 49.25 (n)
worm
(Caenorhabditis elegans)
Secernentea frm-10 34
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for FRMD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMD8 Gene

ENSEMBL:
Gene Tree for FRMD8 (if available)
TreeFam:
Gene Tree for FRMD8 (if available)

Paralogs for FRMD8 Gene

Paralogs for FRMD8 Gene

(1) SIMAP similar genes for FRMD8 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FRMD8 Gene

genes like me logo Genes that share paralogs with FRMD8: view

Variants for FRMD8 Gene

Sequence variations from dbSNP and Humsavar for FRMD8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000253045 -- 65,413,554(+) AATAA(C/T)GAGGG downstream-variant-500B
rs1000262445 -- 65,402,303(+) AAGCC(A/G)AGATG intron-variant
rs1000277690 -- 65,399,242(+) GACCC(A/G)CCTGC intron-variant
rs1000415190 -- 65,385,800(+) TATAA(-/AT)TTTTT upstream-variant-2KB
rs1000639810 -- 65,409,262(+) TTGTA(C/T)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD8 Gene

Variant ID Type Subtype PubMed ID
nsv951016 CNV deletion 24416366
nsv526181 CNV gain 19592680
nsv1145541 CNV deletion 24896259
nsv1122634 CNV deletion 24896259
esv2422285 CNV deletion 17116639

Variation tolerance for FRMD8 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRMD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRMD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMD8 Gene

Disorders for FRMD8 Gene

Relevant External Links for FRMD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRMD8

No disorders were found for FRMD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMD8 Gene

Publications for FRMD8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 60

Products for FRMD8 Gene

Sources for FRMD8 Gene

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