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Aliases for FRMD8 Gene

Aliases for FRMD8 Gene

  • FERM Domain Containing 8 2 3
  • FERM Domain-Containing Protein 8 3
  • FKSG44 3

External Ids for FRMD8 Gene

Previous GeneCards Identifiers for FRMD8 Gene

  • GC11P064911
  • GC11P065154
  • GC11P061480

Summaries for FRMD8 Gene

GeneCards Summary for FRMD8 Gene

FRMD8 (FERM Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is KRIT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD8 Gene

Genomics for FRMD8 Gene

Regulatory Elements for FRMD8 Gene

Genomic Location for FRMD8 Gene

Start:
65,386,570 bp from pter
End:
65,413,525 bp from pter
Size:
26,956 bases
Orientation:
Plus strand

Genomic View for FRMD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD8 Gene

Proteins for FRMD8 Gene

  • Protein details for FRMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ67-FRMD8_HUMAN
    Recommended name:
    FERM domain-containing protein 8
    Protein Accession:
    Q9BZ67
    Secondary Accessions:
    • B4E2P1
    • Q86V56
    • Q8NCB5

    Protein attributes for FRMD8 Gene

    Size:
    464 amino acids
    Molecular mass:
    51218 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRMD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRMD8 Gene

Proteomics data for FRMD8 Gene at MOPED

Post-translational modifications for FRMD8 Gene

  • Ubiquitination at Lys153
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FRMD8 Gene

Domains for FRMD8 Gene

Protein Domains for FRMD8 Gene

Suggested Antigen Peptide Sequences for FRMD8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZ67

UniProtKB/Swiss-Prot:

FRMD8_HUMAN :
  • Q9BZ67
Domain:
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with FRMD8: view

No data available for Gene Families for FRMD8 Gene

Function for FRMD8 Gene

Gene Ontology (GO) - Molecular Function for FRMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FRMD8: view

Phenotypes for FRMD8 Gene

GenomeRNAi human phenotypes for FRMD8:
genes like me logo Genes that share phenotypes with FRMD8: view

miRNA for FRMD8 Gene

miRTarBase miRNAs that target FRMD8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FRMD8 Gene

Localization for FRMD8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRMD8 Gene COMPARTMENTS Subcellular localization image for FRMD8 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FRMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FRMD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FRMD8 Gene

Pathways for FRMD8 Gene

SuperPathways for FRMD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD8 Gene

None

No data available for Pathways by source for FRMD8 Gene

Transcripts for FRMD8 Gene

Unigene Clusters for FRMD8 Gene

FERM domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD8 Gene

No ASD Table

Relevant External Links for FRMD8 Gene

GeneLoc Exon Structure for
FRMD8
ECgene alternative splicing isoforms for
FRMD8

Expression for FRMD8 Gene

mRNA expression in normal human tissues for FRMD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRMD8 Gene

SOURCE GeneReport for Unigene cluster for FRMD8 Gene Hs.578433

genes like me logo Genes that share expressions with FRMD8: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FRMD8 Gene

Orthologs for FRMD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRMD8 35
  • 99.35 (n)
  • 99.57 (a)
cow
(Bos Taurus)
Mammalia FRMD8 35
  • 88.46 (n)
  • 88.31 (a)
FRMD8 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRMD8 35
  • 87.04 (n)
  • 86.83 (a)
FRMD8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frmd8 35
  • 84.59 (n)
  • 88.12 (a)
Frmd8 16
Frmd8 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRMD8 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRMD8 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frmd8 35
  • 84.48 (n)
  • 87.07 (a)
lizard
(Anolis carolinensis)
Reptilia FRMD8 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53754 35
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd8 35
  • 60.46 (n)
  • 61.43 (a)
zebrafish
(Danio rerio)
Actinopterygii frmd8 35
  • 59.46 (n)
  • 57.93 (a)
frmd8 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002678 35
  • 49.96 (n)
  • 34.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bili 35
  • 49.25 (n)
  • 40.07 (a)
Bili 36
  • 15 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea frm-10 36
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for FRMD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMD8 Gene

ENSEMBL:
Gene Tree for FRMD8 (if available)
TreeFam:
Gene Tree for FRMD8 (if available)

Paralogs for FRMD8 Gene

Paralogs for FRMD8 Gene

Selected SIMAP similar genes for FRMD8 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FRMD8 Gene

genes like me logo Genes that share paralogs with FRMD8: view

Variants for FRMD8 Gene

Sequence variations from dbSNP and Humsavar for FRMD8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs472852 -- 65,400,290(-) TTCTG(C/T)CCAGG intron-variant
rs478121 -- 65,410,279(+) GATCA(C/T)GAGGT intron-variant
rs578270 -- 65,390,349(+) GCCAT(A/G)GGCCG intron-variant
rs647284 -- 65,413,412(-) CACAA(C/T)GGATG utr-variant-3-prime
rs651283 -- 65,387,713(+) ttttg(C/T)atttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD8 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
esv2422285 CNV Deletion 17116639
dgv1175n71 CNV Loss 21882294
nsv897717 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897719 CNV Loss 21882294

Relevant External Links for FRMD8 Gene

HapMap Linkage Disequilibrium report
FRMD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMD8 Gene

Disorders for FRMD8 Gene

No disorders were found for FRMD8 Gene.

No data available for UniProtKB/Swiss-Prot for FRMD8 Gene

Publications for FRMD8 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for FRMD8 Gene

Sources for FRMD8 Gene

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