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Aliases for FRMD8 Gene

Aliases for FRMD8 Gene

  • FERM Domain Containing 8 2 3 5
  • FERM Domain-Containing Protein 8 3
  • FKSG44 3

External Ids for FRMD8 Gene

Previous GeneCards Identifiers for FRMD8 Gene

  • GC11P064911
  • GC11P065154
  • GC11P061480

Summaries for FRMD8 Gene

GeneCards Summary for FRMD8 Gene

FRMD8 (FERM Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is KRIT1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD8 Gene

Genomics for FRMD8 Gene

Regulatory Elements for FRMD8 Gene

Enhancers for FRMD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 36.3 +103.5 103514 40.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 LOC105369352 ZFPL1 KAT5 ENSG00000254461 EIF1AD NEAT1 FRMD8 EHBP1L1 POLA2 LOC101927789
GH11G065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 26.8 +37.6 37612 18.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZFPL1 NEAT1 LOC105369352 KAT5 EIF1AD FRMD8 MUS81 PCNX3 POLA2 ENSG00000255320
GH11G065851 1.4 ENCODE dbSUPER 23.3 +470.9 470915 12.2 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SNX32 EIF1AD PCNX3 ZFPL1 ENSG00000258297 FRMD8 POLA2 KAT5 ENSG00000255320 CTSW
GH11G065452 1.3 ENCODE dbSUPER 23.6 +68.5 68458 5.2 HDGF CREB3L1 ARNT WRNIP1 ARID4B SIN3A ZNF143 FOS KLF13 ZHX2 NEAT1 FRMD8 ZFPL1 EIF1AD PCNX3 SLC25A45 MALAT1 ENSG00000255478 KAT5 ENSG00000255320
GH11G066342 1.8 FANTOM5 ENCODE dbSUPER 14.1 +962.0 961975 11.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 RIN1 EIF1AD ENSG00000258297 ACTN3 RAD9A RBM14 KAT5 ENSG00000255320 LOC105369352 CTSF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FRMD8 on UCSC Golden Path with GeneCards custom track

Promoters for FRMD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040827 330 1001 CREB3L1 ARID4B SIN3A ZBTB7B ZNF143 FOS KLF13 NFYC SMARCB1 ZNF592

Genomic Location for FRMD8 Gene

Chromosome:
11
Start:
65,386,570 bp from pter
End:
65,413,525 bp from pter
Size:
26,956 bases
Orientation:
Plus strand

Genomic View for FRMD8 Gene

Genes around FRMD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD8 Gene

Proteins for FRMD8 Gene

  • Protein details for FRMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ67-FRMD8_HUMAN
    Recommended name:
    FERM domain-containing protein 8
    Protein Accession:
    Q9BZ67
    Secondary Accessions:
    • B4E2P1
    • Q86V56
    • Q8NCB5

    Protein attributes for FRMD8 Gene

    Size:
    464 amino acids
    Molecular mass:
    51218 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRMD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRMD8 Gene

Post-translational modifications for FRMD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD8 Gene

Domains & Families for FRMD8 Gene

Gene Families for FRMD8 Gene

Suggested Antigen Peptide Sequences for FRMD8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FRMD8: view

No data available for UniProtKB/Swiss-Prot for FRMD8 Gene

Function for FRMD8 Gene

Gene Ontology (GO) - Molecular Function for FRMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FRMD8: view
genes like me logo Genes that share phenotypes with FRMD8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRMD8 Gene

Localization for FRMD8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRMD8 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FRMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FRMD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FRMD8 Gene

Pathways & Interactions for FRMD8 Gene

SuperPathways for FRMD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FRMD8 Gene

Drugs & Compounds for FRMD8 Gene

No Compound Related Data Available

Transcripts for FRMD8 Gene

Unigene Clusters for FRMD8 Gene

FERM domain containing 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD8 Gene

No ASD Table

Relevant External Links for FRMD8 Gene

GeneLoc Exon Structure for
FRMD8
ECgene alternative splicing isoforms for
FRMD8

Expression for FRMD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRMD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FRMD8 Gene

This gene is overexpressed in Serum (31.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FRMD8 Gene



Protein tissue co-expression partners for FRMD8 Gene

NURSA nuclear receptor signaling pathways regulating expression of FRMD8 Gene:

FRMD8

SOURCE GeneReport for Unigene cluster for FRMD8 Gene:

Hs.578433

Evidence on tissue expression from TISSUES for FRMD8 Gene

  • Liver(4.5)
  • Intestine(4.4)
  • Nervous system(2.9)
  • Heart(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FRMD8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRMD8 Gene

Orthologs for FRMD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRMD8 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia FRMD8 34 35
  • 88.46 (n)
dog
(Canis familiaris)
Mammalia FRMD8 34 35
  • 87.04 (n)
mouse
(Mus musculus)
Mammalia Frmd8 34 16 35
  • 84.59 (n)
rat
(Rattus norvegicus)
Mammalia Frmd8 34
  • 84.48 (n)
oppossum
(Monodelphis domestica)
Mammalia FRMD8 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRMD8 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRMD8 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd8 34
  • 60.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53754 34
zebrafish
(Danio rerio)
Actinopterygii frmd8 34 35
  • 59.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002678 34
  • 49.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bili 34 35
  • 49.25 (n)
worm
(Caenorhabditis elegans)
Secernentea frm-10 35
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for FRMD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMD8 Gene

ENSEMBL:
Gene Tree for FRMD8 (if available)
TreeFam:
Gene Tree for FRMD8 (if available)

Paralogs for FRMD8 Gene

Paralogs for FRMD8 Gene

(1) SIMAP similar genes for FRMD8 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FRMD8 Gene

genes like me logo Genes that share paralogs with FRMD8: view

Variants for FRMD8 Gene

Sequence variations from dbSNP and Humsavar for FRMD8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000253045 -- 65,413,554(+) AATAA(C/T)GAGGG downstream-variant-500B
rs1000262445 -- 65,402,303(+) AAGCC(A/G)AGATG intron-variant
rs1000277690 -- 65,399,242(+) GACCC(A/G)CCTGC intron-variant
rs1000415190 -- 65,385,800(+) TATAA(-/AT)TTTTT upstream-variant-2KB
rs1000639810 -- 65,409,262(+) TTGTA(C/T)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD8 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv1122634 CNV deletion 24896259
nsv1145541 CNV deletion 24896259
nsv526181 CNV gain 19592680
nsv951016 CNV deletion 24416366

Variation tolerance for FRMD8 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRMD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRMD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMD8 Gene

Disorders for FRMD8 Gene

Relevant External Links for FRMD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRMD8

No disorders were found for FRMD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMD8 Gene

Publications for FRMD8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FRMD8 Gene

Sources for FRMD8 Gene

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