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Aliases for FRMD6 Gene

Aliases for FRMD6 Gene

  • FERM Domain Containing 6 2 3
  • C14orf31 3 4 6
  • Willin 3 4 6
  • Expanded Homolog 2 3
  • 4.1 Ezrin Radixin Moesin (FERM)-Containing Protein 3
  • Chromosome 14 Open Reading Frame 31 2
  • FERM Domain-Containing Protein 6 3
  • C14_5320 3
  • EX1 3

External Ids for FRMD6 Gene

Previous Symbols for FRMD6 Gene

  • C14orf31

Summaries for FRMD6 Gene

GeneCards Summary for FRMD6 Gene

FRMD6 (FERM Domain Containing 6) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway. An important paralog of this gene is FRMD1.

Gene Wiki entry for FRMD6 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD6 Gene

Genomics for FRMD6 Gene

Genomic Location for FRMD6 Gene

Start:
51,489,100 bp from pter
End:
51,730,727 bp from pter
Size:
241,628 bases
Orientation:
Plus strand

Genomic View for FRMD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRMD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD6 Gene

Regulatory Elements for FRMD6 Gene

Proteins for FRMD6 Gene

  • Protein details for FRMD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NE9-FRMD6_HUMAN
    Recommended name:
    FERM domain-containing protein 6
    Protein Accession:
    Q96NE9
    Secondary Accessions:
    • D3DSB9
    • Q5HYF2
    • Q8N2X1
    • Q8WUH7

    Protein attributes for FRMD6 Gene

    Size:
    622 amino acids
    Molecular mass:
    72044 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRMD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRMD6 Gene

Proteomics data for FRMD6 Gene at MOPED

Post-translational modifications for FRMD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD6 Gene

Domains for FRMD6 Gene

UniProtKB/Swiss-Prot:

FRMD6_HUMAN
Domain:
  • Contains 1 FERM domain.:
    • Q96NE9
genes like me logo Genes that share domains with FRMD6: view

No data available for Gene Families for FRMD6 Gene

Function for FRMD6 Gene

Gene Ontology (GO) - Molecular Function for FRMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FRMD6: view

miRNA for FRMD6 Gene

miRTarBase miRNAs that target FRMD6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FRMD6 Gene

Localization for FRMD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMD6 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Can colocalize with actin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRMD6 Gene COMPARTMENTS Subcellular localization image for FRMD6 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FRMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0043296 apical junction complex IEA --
genes like me logo Genes that share ontologies with FRMD6: view

Pathways for FRMD6 Gene

SuperPathways for FRMD6 Gene

Superpath Contained pathways
1 Hippo signaling pathway
genes like me logo Genes that share pathways with FRMD6: view

Pathways by source for FRMD6 Gene

1 KEGG pathway for FRMD6 Gene

Gene Ontology (GO) - Biological Process for FRMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003383 apical constriction IEA --
GO:0032970 regulation of actin filament-based process IEA --
GO:0034613 cellular protein localization IEA --
genes like me logo Genes that share ontologies with FRMD6: view

Transcripts for FRMD6 Gene

Unigene Clusters for FRMD6 Gene

FERM domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7:
SP8:
SP9: -
SP10:
SP11: -
SP12:
SP13:
SP14: - - - - - - - -

ExUns: 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8: -
SP9:
SP10:
SP11: - -
SP12: -
SP13:
SP14:

Relevant External Links for FRMD6 Gene

GeneLoc Exon Structure for
FRMD6
ECgene alternative splicing isoforms for
FRMD6

Expression for FRMD6 Gene

mRNA expression in normal human tissues for FRMD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRMD6 Gene

SOURCE GeneReport for Unigene cluster for FRMD6 Gene Hs.434914

genes like me logo Genes that share expressions with FRMD6: view

Orthologs for FRMD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRMD6 36
  • 99.84 (n)
  • 100 (a)
FRMD6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRMD6 36
  • 92.71 (n)
  • 98.55 (a)
FRMD6 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRMD6 36
  • 93.57 (n)
  • 98.55 (a)
FRMD6 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frmd6 36
  • 86.23 (n)
  • 93.57 (a)
Frmd6 16
Frmd6 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRMD6 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRMD6 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frmd6 36
  • 85.94 (n)
  • 92.83 (a)
chicken
(Gallus gallus)
Aves FRMD6 36
  • 78.32 (n)
  • 90.13 (a)
FRMD6 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRMD6 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd6 36
  • 78.42 (n)
  • 88.89 (a)
zebrafish
(Danio rerio)
Actinopterygii frmd6 36
  • 69.45 (n)
  • 72.91 (a)
frmd6 37
  • 72 (a)
OneToOne
wufb38g08 36
fruit fly
(Drosophila melanogaster)
Insecta ex 37
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frm-7 37
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
OneToMany
Species with no ortholog for FRMD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMD6 Gene

ENSEMBL:
Gene Tree for FRMD6 (if available)
TreeFam:
Gene Tree for FRMD6 (if available)

Paralogs for FRMD6 Gene

Paralogs for FRMD6 Gene

Selected SIMAP similar genes for FRMD6 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for FRMD6 Gene

genes like me logo Genes that share paralogs with FRMD6: view

Variants for FRMD6 Gene

Sequence variations from dbSNP and Humsavar for FRMD6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs15572 -- 51,729,568(-) AAAAA(A/T)ATGGT utr-variant-3-prime
rs720860 -- 51,632,592(-) AGATA(A/G)CCAGG intron-variant
rs731715 -- 51,715,363(+) CCTTC(A/T)GCCCG synonymous-codon, reference, upstream-variant-2KB
rs749349 -- 51,716,887(+) AATTA(C/G/T)GTGCA intron-variant, upstream-variant-2KB
rs749820 -- 51,717,721(-) AAAGG(C/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD6 Gene

Variant ID Type Subtype PubMed ID
nsv528274 CNV Loss 19592680
nsv1277 CNV Insertion 18451855
esv1010904 CNV Deletion 20482838
esv2658618 CNV Deletion 23128226
nsv528065 CNV Loss 19592680
nsv526899 CNV Loss 19592680
nsv901946 CNV Loss 21882294
esv2672342 CNV Deletion 23128226

Relevant External Links for FRMD6 Gene

HapMap Linkage Disequilibrium report
FRMD6
Human Gene Mutation Database (HGMD)
FRMD6

Disorders for FRMD6 Gene

Relevant External Links for FRMD6

Genetic Association Database (GAD)
FRMD6
genes like me logo Genes that share disorders with FRMD6: view

No data available for UniProtKB/Swiss-Prot for FRMD6 Gene

Publications for FRMD6 Gene

  1. A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'. (PMID: 16137681) Gunn-Moore F.J. … Guild S. (FEBS Lett. 2005) 3 4 23
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genome-wide association study of the Protein C anticoagulant pathway. (PMID: 22216198) Athanasiadis G. … Soria J.M. (PLoS ONE 2011) 3 49

Products for FRMD6 Gene

Sources for FRMD6 Gene

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