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Aliases for FRMD5 Gene

Aliases for FRMD5 Gene

  • FERM Domain Containing 5 2 3 5

External Ids for FRMD5 Gene

Previous GeneCards Identifiers for FRMD5 Gene

  • GC15M041953
  • GC15M044162
  • GC15M020989

Summaries for FRMD5 Gene

GeneCards Summary for FRMD5 Gene

FRMD5 (FERM Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include cytoskeletal protein binding. An important paralog of this gene is FRMD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD5 Gene

Genomics for FRMD5 Gene

Regulatory Elements for FRMD5 Gene

Promoters for FRMD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FRMD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FRMD5 Gene

43,870,761 bp from pter
44,195,577 bp from pter
324,817 bases
Minus strand

Genomic View for FRMD5 Gene

Genes around FRMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD5 Gene

Proteins for FRMD5 Gene

  • Protein details for FRMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FERM domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • Q8NBG4

    Protein attributes for FRMD5 Gene

    570 amino acids
    Molecular mass:
    65065 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRMD5 Gene


neXtProt entry for FRMD5 Gene

Proteomics data for FRMD5 Gene at MOPED

Post-translational modifications for FRMD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD5 Gene

Domains & Families for FRMD5 Gene

Suggested Antigen Peptide Sequences for FRMD5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FERM domain.
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with FRMD5: view

No data available for Gene Families for FRMD5 Gene

Function for FRMD5 Gene

genes like me logo Genes that share phenotypes with FRMD5: view

Animal Models for FRMD5 Gene

MGI Knock Outs for FRMD5:

Animal Model Products

  • Taconic Biosciences Mouse Models for FRMD5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRMD5 Gene

Localization for FRMD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMD5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FRMD5 Gene COMPARTMENTS Subcellular localization image for FRMD5 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
golgi apparatus 3
nucleus 2
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FRMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FRMD5: view

Pathways & Interactions for FRMD5 Gene

SuperPathways for FRMD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD5 Gene


No data available for Pathways by source and SIGNOR curated interactions for FRMD5 Gene

Drugs & Compounds for FRMD5 Gene

No Compound Related Data Available

Transcripts for FRMD5 Gene

Unigene Clusters for FRMD5 Gene

FERM domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - -

Relevant External Links for FRMD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRMD5 Gene

mRNA expression in normal human tissues for FRMD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRMD5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for FRMD5 Gene

This gene is overexpressed in Frontal cortex (14.1), Monocytes (13.4), Retina (12.7), Heart (10.3), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRMD5 Gene

SOURCE GeneReport for Unigene cluster for FRMD5 Gene Hs.578544

genes like me logo Genes that share expression patterns with FRMD5: view

Protein tissue co-expression partners for FRMD5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FRMD5 Gene

Orthologs for FRMD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FRMD5 35
  • 93.68 (n)
  • 98.25 (a)
FRMD5 36
  • 97 (a)
(Canis familiaris)
Mammalia FRMD5 35
  • 95.09 (n)
  • 98.95 (a)
FRMD5 36
  • 99 (a)
(Mus musculus)
Mammalia Frmd5 35
  • 91.82 (n)
  • 98.38 (a)
Frmd5 16
Frmd5 36
  • 94 (a)
(Pan troglodytes)
Mammalia FRMD5 35
  • 99.88 (n)
  • 100 (a)
FRMD5 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Frmd5 35
  • 91.01 (n)
  • 97.18 (a)
(Monodelphis domestica)
Mammalia FRMD5 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FRMD5 36
  • 80 (a)
(Gallus gallus)
Aves FRMD5 35
  • 83.16 (n)
  • 92.61 (a)
FRMD5 36
  • 92 (a)
(Anolis carolinensis)
Reptilia FRMD5 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd5 35
  • 70.86 (n)
  • 76.26 (a)
(Danio rerio)
Actinopterygii LOC570903 35
  • 77.35 (n)
  • 86.97 (a)
FRMD5 36
  • 73 (a)
FRMD5 (1 of 2) 36
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5022 36
  • 28 (a)
Species with no ortholog for FRMD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FRMD5 Gene

Gene Tree for FRMD5 (if available)
Gene Tree for FRMD5 (if available)

Paralogs for FRMD5 Gene

genes like me logo Genes that share paralogs with FRMD5: view

Variants for FRMD5 Gene

Sequence variations from dbSNP and Humsavar for FRMD5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs545119 -- 43,910,847(+) TTATT(A/C)CAGAT intron-variant
rs645235 -- 43,904,394(+) gacag(A/G)gtctc intron-variant
rs645238 -- 43,904,400(+) gtctc(A/G)ctgtg intron-variant
rs560247 -- 43,906,728(+) TCCCG(A/C)GTAGC intron-variant
rs560376 -- 43,906,767(+) CGGCT(A/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD5 Gene

Variant ID Type Subtype PubMed ID
nsv1515 CNV Insertion 18451855
esv2676192 CNV Deletion 23128226
esv1620375 CNV Insertion 17803354
nsv832989 CNV Gain+Loss 17160897
esv2749628 CNV Deletion 23290073
nsv94497 CNV Loss 16902084
dgv2376n71 CNV Loss 21882294
nsv904176 CNV Loss 21882294

Variation tolerance for FRMD5 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRMD5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMD5 Gene

Disorders for FRMD5 Gene

Relevant External Links for FRMD5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRMD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMD5 Gene

Publications for FRMD5 Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin I^5 subunit and ROCK1. (PMID: 25448675) Hu J. … Zhang H. (FEBS Lett. 2014) 3
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  5. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3

Products for FRMD5 Gene

Sources for FRMD5 Gene

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