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Aliases for FRMD5 Gene

Aliases for FRMD5 Gene

  • FERM Domain Containing 5 2 3 5

External Ids for FRMD5 Gene

Previous GeneCards Identifiers for FRMD5 Gene

  • GC15M041953
  • GC15M044162
  • GC15M020989

Summaries for FRMD5 Gene

GeneCards Summary for FRMD5 Gene

FRMD5 (FERM Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include cytoskeletal protein binding. An important paralog of this gene is FRMD3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD5 Gene

Genomics for FRMD5 Gene

Regulatory Elements for FRMD5 Gene

Enhancers for FRMD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G044101 1.3 Ensembl ENCODE dbSUPER 11.1 +92.9 92890 3.1 HDAC1 SIN3A TCF12 ZNF121 ZSCAN5C FOS CEBPB NFIL3 NFIC KLF16 FRMD5 STRC HNRNPMP1 RNU6-610P ADAL TRIM69 GC15P044099
GH15G044066 1.2 Ensembl ENCODE dbSUPER 10.5 +129.1 129077 0.6 CTCF ZNF654 JUN TRIM22 REST RAD21 RFX5 ZFP69B JUND SMC3 FRMD5 GAPDHP55 GC15P044099
GH15G044156 1 Ensembl ENCODE 11.8 +37.3 37285 3.8 JUN SIN3A FEZF1 ZEB1 HIC1 CTBP1 GATA3 GATA2 FOS TCF7L2 FRMD5 ADAL GC15P044099
GH15G044219 1 Ensembl ENCODE 11.4 -24.2 -24225 0.4 SMARCA5 CTCF ZNF654 ZNF362 TRIM22 ZNF384 REST RAD21 SMARCA4 FOXK2 FRMD5 STRCP1 GC15P044263
GH15G043879 0.9 VISTA dbSUPER 10.7 +315.2 315206 2.6 REST ADAL ENSG00000249839 FRMD5 PIN4P1 GC15M043974
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FRMD5 on UCSC Golden Path with GeneCards custom track

Promoters for FRMD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FRMD5 Gene

43,870,761 bp from pter
44,195,577 bp from pter
324,817 bases
Minus strand

Genomic View for FRMD5 Gene

Genes around FRMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD5 Gene

Proteins for FRMD5 Gene

  • Protein details for FRMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FERM domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • Q8NBG4

    Protein attributes for FRMD5 Gene

    570 amino acids
    Molecular mass:
    65065 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRMD5 Gene


neXtProt entry for FRMD5 Gene

Post-translational modifications for FRMD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD5 Gene

Domains & Families for FRMD5 Gene

Gene Families for FRMD5 Gene

Suggested Antigen Peptide Sequences for FRMD5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FRMD5: view

No data available for UniProtKB/Swiss-Prot for FRMD5 Gene

Function for FRMD5 Gene

Gene Ontology (GO) - Molecular Function for FRMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005178 integrin binding IDA 25448675
GO:0005200 structural constituent of cytoskeleton IBA --
GO:0005515 protein binding IPI 22846708
GO:0008092 cytoskeletal protein binding IEA --
genes like me logo Genes that share ontologies with FRMD5: view
genes like me logo Genes that share phenotypes with FRMD5: view

Animal Models for FRMD5 Gene

MGI Knock Outs for FRMD5:

Animal Model Products

  • Taconic Biosciences Mouse Models for FRMD5

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRMD5 Gene

Localization for FRMD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMD5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRMD5 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
golgi apparatus 3
nucleus 2
plasma membrane 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FRMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA,IBA --
GO:0005912 adherens junction IDA 22846708
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FRMD5: view

Pathways & Interactions for FRMD5 Gene

SuperPathways for FRMD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0030334 regulation of cell migration IMP 22846708
GO:0031032 actomyosin structure organization IBA --
GO:0045785 positive regulation of cell adhesion IMP 25448675
GO:2000146 negative regulation of cell motility IMP 25448675
genes like me logo Genes that share ontologies with FRMD5: view

No data available for Pathways by source and SIGNOR curated interactions for FRMD5 Gene

Drugs & Compounds for FRMD5 Gene

No Compound Related Data Available

Transcripts for FRMD5 Gene

Unigene Clusters for FRMD5 Gene

FERM domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - -

Relevant External Links for FRMD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRMD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRMD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRMD5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for FRMD5 Gene

This gene is overexpressed in Frontal cortex (14.1), Monocytes (13.4), Retina (12.7), Heart (10.3), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FRMD5 Gene

Protein tissue co-expression partners for FRMD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FRMD5 Gene:


SOURCE GeneReport for Unigene cluster for FRMD5 Gene:


Evidence on tissue expression from TISSUES for FRMD5 Gene

  • Nervous system(4.3)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with FRMD5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRMD5 Gene

Orthologs for FRMD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FRMD5 34 35
  • 99.88 (n)
(Canis familiaris)
Mammalia FRMD5 34 35
  • 95.09 (n)
(Bos Taurus)
Mammalia FRMD5 34 35
  • 93.68 (n)
(Mus musculus)
Mammalia Frmd5 34 16 35
  • 91.82 (n)
(Rattus norvegicus)
Mammalia Frmd5 34
  • 91.01 (n)
(Monodelphis domestica)
Mammalia FRMD5 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FRMD5 35
  • 80 (a)
(Gallus gallus)
Aves FRMD5 34 35
  • 83.16 (n)
(Anolis carolinensis)
Reptilia FRMD5 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd5 34
  • 70.86 (n)
(Danio rerio)
Actinopterygii FRMD5 (1 of 2) 35
  • 85 (a)
LOC570903 34
  • 77.35 (n)
FRMD5 35
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5022 35
  • 28 (a)
Species where no ortholog for FRMD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FRMD5 Gene

Gene Tree for FRMD5 (if available)
Gene Tree for FRMD5 (if available)

Paralogs for FRMD5 Gene

Variants for FRMD5 Gene

Sequence variations from dbSNP and Humsavar for FRMD5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000003511 -- 43,978,275(+) TACCA(G/T)TACAA intron-variant
rs1000010283 -- 44,037,963(+) TCTGT(G/T)GTTTC intron-variant
rs1000012662 -- 43,975,259(+) ACTAA(C/T)AAGGA intron-variant
rs1000018425 -- 43,884,296(+) ATTCT(A/G)GGAGA intron-variant
rs1000028443 -- 43,884,594(+) AAGTT(C/T)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD5 Gene

Variant ID Type Subtype PubMed ID
esv1620375 CNV insertion 17803354
esv2676192 CNV deletion 23128226
esv2749628 CNV deletion 23290073
esv3636301 CNV loss 21293372
esv3636302 CNV loss 21293372
esv3636303 CNV loss 21293372
esv3636304 CNV loss 21293372
nsv1044435 CNV gain 25217958
nsv1045362 CNV loss 25217958
nsv1050263 CNV loss 25217958
nsv1515 CNV insertion 18451855
nsv471951 CNV novel sequence insertion 20440878
nsv476878 CNV novel sequence insertion 20440878
nsv569298 CNV loss 21841781
nsv832989 CNV gain+loss 17160897
nsv94497 CNV deletion 16902084
nsv984063 CNV duplication 23825009

Variation tolerance for FRMD5 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRMD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMD5 Gene

Disorders for FRMD5 Gene

Relevant External Links for FRMD5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRMD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMD5 Gene

Publications for FRMD5 Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin I^5 subunit and ROCK1. (PMID: 25448675) Hu J. … Zhang H. (FEBS Lett. 2014) 3 64

Products for FRMD5 Gene

Sources for FRMD5 Gene

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