Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FRMD4B Gene

protein-coding   GIFtS: 48
GCID: GC03M069219

FERM domain containing 4B
 Explore 1 disease affiliated with
FRMD4B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FRMD4B    

Aliases
for FRMD4B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
FERM Domain Containing 4B1 2
GRSP11 2
KIAA10131 3
GRP1-Binding Protein GRSP12 3
6030440G05Rik2
FERM Domain-Containing Protein 4B2

External Ids:    HGNC: 248861   Entrez Gene: 231502   Ensembl: ENSG000001145417   UniProtKB: Q9Y2L63   

Export aliases for FRMD4B gene to outside databases

Previous GC identifer: GC03M069302


Summaries
for FRMD4B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: FRM4B_HUMAN, Q9Y2L6
Function: Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to
insulin receptor signaling. May function as a scaffolding protein (By similarity)




Genomic Views
for FRMD4B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022459.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FRMD4B gene promoter:
         HOXA9   HOXA9B   POU2F1   POU2F1a   Cart-1   Nkx2-5   Tal-1beta   E47   Meis-1   Meis-1b   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FRMD4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRMD4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14.2

FRMD4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRMD4B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M069219:  view genomic region     (about GC identifiers)

Start:
 69,219,141 bp from pter      End:
 69,591,734 bp from pter
Size:
 372,594 bases      Orientation:
 minus strand

Proteins
for FRMD4B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FRM4B_HUMAN, Q9Y2L6 (See protein sequence)
Recommended Name: FERM domain-containing protein 4B  
Size: 1034 amino acids; 118047 Da
Subunit: Interacts with GRP1 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Sequence caution: Sequence=BAA76857.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8TAI3
Alternative splicing: 2 isoforms:  Q9Y2L6-1   Q9Y2L6-2   

Explore the universe of human proteins at neXtProt for FRMD4B: NX_Q9Y2L6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2L6

    • FRMD4B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055938.1  
    ENSEMBL proteins: 
     ENSP00000381549   ENSP00000418682   ENSP00000419869   ENSP00000420735   ENSP00000418962  
     ENSP00000418373   ENSP00000418023   ENSP00000417550   ENSP00000417765   ENSP00000437658  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for FRMD4B 
    GenScript Custom Purified and Recombinant Proteins Services for FRMD4B
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FRMD4B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--


    FRMD4B for ontologies           About GeneDecksing



    FRMD4B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FRMD4B 
    GenScript Custom Superior Antibodies Services for FRMD4B
    Novus Biologicals FRMD4B Antibody
    Search for Antibodies for FRMD4B at Abcam  
    Uscn Antibodies for FRMD4B
    Search ThermoFisher Antibodies for FRMD4B

    Assay Products for FRMD4B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FRMD4B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FRMD4B

    Protein Domains /
    Families
    for FRMD4B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FRMD4B for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR021774 DUF3338
     IPR019747 FERM_CS
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2L6

    ProtoNet protein and cluster: Q9Y2L6

    1 Blocks protein family: IPB000299 Band 4.1 domain

    UniProtKB/Swiss-Prot: FRM4B_HUMAN, Q9Y2L6
    Similarity: Contains 1 FERM domain


    Function
    for FRMD4B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FRM4B_HUMAN, Q9Y2L6
    Function: Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to
    insulin receptor signaling. May function as a scaffolding protein (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: FRMD4B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRMD4B
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate FRMD4B (see all 50):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-let-7d hsa-miR-429 hsa-miR-106a hsa-miR-192 hsa-let-7g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRMD4B (see all 4)
    OriGene shRNA RFP: FRMD4B
    OriGene siRNA: FRMD4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRMD4B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FRMD4B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD4B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD4B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FRMD4B (NM_015123)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRMD4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRMD4B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FRMD4B
    Search LifeMap BioReagents cell lines for FRMD4B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMD4B

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    FRMD4B for ontologies           About GeneDecksing



    Pathways & Interactions
    for FRMD4B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FRMD4B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for FRMD4B (Q9Y2L63 ENSP000003815494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYTH3O437393, ENSP000002970444I2D: score=1 STRING: ENSP00000297044
    STAT1P422243I2D: score=2 
    YWHAEP622583I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0090162establishment of epithelial cell polarity IEA--


    FRMD4B for ontologies           About GeneDecksing



    Drugs & Compounds
    for FRMD4B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FRMD4B
    Search CenterWatch for drugs/clinical trials and news about FRMD4B / FRM4B 

    Transcripts
    for FRMD4B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FRMD4B gene: 
    NM_015123.1  

    Unigene Cluster for FRMD4B:

    FERM domain containing 4B
    Hs.709671  [show with all ESTs]
    Unigene Representative Sequence: NM_015123
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000398540(uc003dnu.2 uc011bga.1 uc003dnw.2) ENST00000478263
    ENST00000462512 ENST00000497475 ENST00000489817 ENST00000470070(uc003dnx.1)
    ENST00000483668 ENST00000487751 ENST00000493880 ENST00000473029 ENST00000460709
    ENST00000473188(uc003dny.3) ENST00000459638 ENST00000462308 ENST00000497880
    ENST00000497757 ENST00000493127 ENST00000462888

    miRNA
    Products:             		 OriGene 3'-UTR Clone: FRMD4B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRMD4B
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate FRMD4B (see all 50):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-let-7d hsa-miR-429 hsa-miR-106a hsa-miR-192 hsa-let-7g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRMD4B (see all 4)
    OriGene shRNA RFP: FRMD4B
    OriGene siRNA: FRMD4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRMD4B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD4B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD4B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FRMD4B (NM_015123)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FRMD4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRMD4B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRMD4B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRMD4B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRMD4B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRMD4B

    Additional cDNA sequence: 

    AB023230.1 AK000244.1 AK024086.1 AK091076.1 AK295045.1 AL110231.1 AL832231.1 BC028291.1 
    BC043396.1 BC057836.1 BC110637.1 CR749420.1 

    22 DOTS entries:

    DT.447219  DT.100764224  DT.101974415  DT.91969423  DT.40112537  DT.120928436  DT.101971013  DT.92045238 
    DT.95365765  DT.100036276  DT.120928366  DT.97765399  DT.120928352  DT.120928452  DT.120928474  DT.95069372 
    DT.95249147  DT.95299113  DT.100650757  DT.40256844  DT.75108015  DT.92024187 

    24/123 AceView cDNA sequences (see all 123):

    AU118463 BX279831 AV728703 AK024086 AV649269 BU753321 BG257414 AA187838 
    AI079463 BF109694 BU619070 BU689253 AI419395 BG502447 BM991639 CD676767 
    AA489758 AW192147 BM662448 AL601610 BC028291 AL832231 CK429366 AI658773 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FRMD4B (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23
    SP1:                                                                                                                                                            
    SP2:                    -     -     -     -                 -                                                                                                   
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for FRMD4B

    Expression
    for FRMD4B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FRMD4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATATATAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FRMD4B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See FRMD4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FRMD4B

    SOURCE GeneReport for Unigene cluster: Hs.709671
        SABiosciences Custom PCR Arrays for FRMD4B
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRMD4B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRMD4B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRMD4B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRMD4B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMD4B

    Orthologs
    for FRMD4B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FRMD4B gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FRMD4B1 FERM domain containing 4B 76.49(n)
    83.24(a)    		   426071  XM_423748.3  XP_423748.2 
    lizard
    (Anolis carolinensis)    		 Reptilia FRMD4B6
    --
    		 --
    		 79(a)
    2(a)
    		 1 ↔ 1
    possible ortholog
    		 2(182173457-182251123)
    GL343297.1(551081-565477)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.20282 Transcribed sequence with weak similarity to protein more 76(n)    CF523470.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003335661 FERM domain-containing protein 4B-like 61.16(n)
    58.46(a)    		   100333566  XM_002662509.2  XP_002662555.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea F07C6.46
    		 Protein F07C6.4, isoform a
    		 12(a)
    		 1 → many
    		 IV(12805907-12830085)


    ENSEMBL Gene Tree for FRMD4B (if available)
    TreeFam Gene Tree for FRMD4B (if available) 

    Paralogs
    for FRMD4B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FRMD4B gene
    MSN2  FRMD4A2  NF22  RDX2  EZR2  C1orf1062  
    10 SIMAP similar genes for FRMD4B using alignment to 12 protein entries:     FRM4B_HUMAN (see all proteins):
    FRMD4A    RDX    EZR-ROS1    PTPN14    PTPN21    FRMD5
    MSN    EZR    PTPN4    VIL2

    FRMD4B for paralogs           About GeneDecksing



    Genomic Variants
    for FRMD4B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4480 NCBI SNPs in FRMD4B are shown (see all 4480)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs124945411,2
    		C,A,H,--69218696(+) AGAGAC/TGGGGT 1 -- ds50018Minor allele frequency- T:0.07NA WA CSA 15
    rs1823212121,2
    		--69218715(+) GTTGTC/TCAGGC 1 -- ds50010--------
    rs1873850991,2
    		--69218719(+) TCCAGG/TCTGGT 1 -- ds50010--------
    rs1117912391,2
    		C,--69218760(+) ACTTCA/GGCCTC 1 -- ds50010--------
    rs1467947931,2
    		--69218763(+) TCGGCC/TTCCCA 1 -- ds50010--------
    rs1405828961,2
    		--69219009(+) TAATTC/TCTTGA 1 -- ds50010--------
    rs67651971,2
    		C,F,A,H,--69219110(+) TCTCAT/CCAGTC 1 -- ds500120Minor allele frequency- C:0.22NS EA NA WA CSA 931
    rs1457051691,2
    		--69219161(+) GGCAAA/CTTTAT 1 -- ut310--------
    rs67653091,2
    		C,A,H,--69219251(+) TGAACT/CATGTT 1 -- ut318Minor allele frequency- C:0.30NA WA EA 368
    rs1386354081,2
    		--69219259(+) GTTTTA/TAATGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FRMD4B (69219141 - 69469141 bp, first 250kb of FRMD4B)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for FRMD4B
         1 CNV: 6187
         3 Indels: 79792 91349 91350

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRMD4B
    DNA2.0 Custom Variant and Variant Library Synthesis for FRMD4B

    Disorders / Diseases
    for FRMD4B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FRMD4B for disorders           About GeneDecksing

    1 disease for FRMD4B:    About MalaCards
    celiac disease

    Human Genome Epidemiology (HuGE) Navigator: FRMD4B (5 documents)

    Export disorders for FRMD4B gene to outside databases

    Publications
    for FRMD4B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FRMD4B gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with FRMD4B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. (PubMed id 11445584)1, 3, 9 Klarlund J.K....Czech M.P. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Association of an intronic, but not any exonic, FRMD4 B sequence variant and heart failure. (PubMed id 20718813)1 Matkovich S.J....Dorn G.W. (2010)
    7. Common variants in HSPB7 and FRMD4B associated with a dvanced heart failure. (PubMed id 20124441)1 Cappola T.P....Dorn G.W. (2010)
    8. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1 Dubois P.C....van Heel D.A. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    External Searches for FRMD4B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FRMD4B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23150 HGNC: 24886 AceView: FRMD4B Ensembl:ENSG00000114541 euGenes: HUgn23150
    ECgene: FRMD4B H-InvDB: FRMD4B

    Other Databases showing FRMD4B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1013

    Specialized Databases showing FRMD4B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FRMD4B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FRMD4B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FRMD4B gene:
    Search GeneIP for patents involving FRMD4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FRMD4B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for FRMD4B  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRMD4B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRMD4B  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FRMD4B   OriGene 3'-UTR Clone for FRMD4B  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD4B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD4B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FRMD4B   OriGene Custom Protein Services for FRMD4B  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FRMD4B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRMD4B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRMD4B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRMD4B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRMD4B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRMD4B
     GenScript Custom Purified and Recombinant Proteins Services for FRMD4B GenScript cDNA clones with any tag delivered in your preferred vector for FRMD4B
     GenScript Custom Assay Services for FRMD4B GenScript Custom Superior Antibodies Services for FRMD4B
     GenScript Custom overexpressing Cell Line Services for FRMD4B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FRMD4B promoter
     Search Chromatin IP Primers for FRMD4B
     RT2 qPCR Primer Assay in human, mouse, rat FRMD4B
     Search GNC Networks for FRMD4B
     SABiosciences Custom PCR Arrays for FRMD4B
     Search Tocris compounds for FRMD4B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FRMD4B antibodies
     Search for Antibodies for FRMD4B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FRMD4B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FRMD4B Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FRMD4B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMD4B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FRMD4B
     Browse SwitchGear Promoter luciferase reporter plasmids for FRMD4B
     Search ThermoFisher Antibodies for FRMD4B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRMD4B
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FRMD4B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4