Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FRMD4B Gene

Aliases for FRMD4B Gene

  • FERM Domain Containing 4B 2 3
  • GRP1-Binding Protein GRSP1 3 4
  • FERM Domain-Containing Protein 4B 3
  • 6030440G05Rik 3
  • KIAA1013 4
  • GRSP1 3

External Ids for FRMD4B Gene

Summaries for FRMD4B Gene

Entrez Gene Summary for FRMD4B Gene

  • This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]

GeneCards Summary for FRMD4B Gene

FRMD4B (FERM Domain Containing 4B) is a Protein Coding gene. An important paralog of this gene is C1orf106.

UniProtKB/Swiss-Prot for FRMD4B Gene

  • Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD4B Gene

Genomics for FRMD4B Gene

Genomic Location for FRMD4B Gene

Start:
69,169,990 bp from pter
End:
69,542,583 bp from pter
Size:
372,594 bases
Orientation:
Minus strand

Genomic View for FRMD4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRMD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD4B Gene

Regulatory Elements for FRMD4B Gene

Proteins for FRMD4B Gene

  • Protein details for FRMD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2L6-FRM4B_HUMAN
    Recommended name:
    FERM domain-containing protein 4B
    Protein Accession:
    Q9Y2L6
    Secondary Accessions:
    • Q8TAI3

    Protein attributes for FRMD4B Gene

    Size:
    1034 amino acids
    Molecular mass:
    118047 Da
    Quaternary structure:
    • Interacts with GRP1.
    SequenceCaution:
    • Sequence=BAA76857.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FRMD4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRMD4B Gene

Proteomics data for FRMD4B Gene at MOPED

Post-translational modifications for FRMD4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD4B Gene

Domains for FRMD4B Gene

UniProtKB/Swiss-Prot:

FRM4B_HUMAN
Domain:
  • Contains 1 FERM domain.:
    • Q9Y2L6
genes like me logo Genes that share domains with FRMD4B: view

No data available for Gene Families for FRMD4B Gene

Function for FRMD4B Gene

Molecular function for FRMD4B Gene

UniProtKB/Swiss-Prot Function: Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity).

Gene Ontology (GO) - Molecular Function for FRMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FRMD4B: view

miRNA for FRMD4B Gene

miRTarBase miRNAs that target FRMD4B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FRMD4B Gene

Localization for FRMD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMD4B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRMD4B Gene COMPARTMENTS Subcellular localization image for FRMD4B gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FRMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005615 extracellular space IDA 23580065
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FRMD4B: view

Pathways for FRMD4B Gene

SuperPathways for FRMD4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090162 establishment of epithelial cell polarity IEA --
genes like me logo Genes that share ontologies with FRMD4B: view

No data available for Pathways by source for FRMD4B Gene

Transcripts for FRMD4B Gene

Unigene Clusters for FRMD4B Gene

FERM domain containing 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD4B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23
SP1:
SP2: - - - - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for FRMD4B Gene

GeneLoc Exon Structure for
FRMD4B
ECgene alternative splicing isoforms for
FRMD4B

Expression for FRMD4B Gene

mRNA expression in normal human tissues for FRMD4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRMD4B Gene

SOURCE GeneReport for Unigene cluster for FRMD4B Gene Hs.709671

genes like me logo Genes that share expressions with FRMD4B: view

Orthologs for FRMD4B Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRMD4B 36
  • 99.55 (n)
  • 99.42 (a)
FRMD4B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRMD4B 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRMD4B 36
  • 91.59 (n)
  • 95.36 (a)
FRMD4B 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frmd4b 36
  • 86.73 (n)
  • 93.47 (a)
Frmd4b 16
Frmd4b 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRMD4B 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRMD4B 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frmd4b 36
  • 87.4 (n)
  • 93.91 (a)
chicken
(Gallus gallus)
Aves FRMD4B 36
  • 76.49 (n)
  • 83.24 (a)
FRMD4B 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRMD4B 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd4b 36
  • 68.34 (n)
  • 69.65 (a)
Str.2028 36
zebrafish
(Danio rerio)
Actinopterygii frmd4ba 37
  • 55 (a)
OneToMany
frmd4bb 36
  • 60.78 (n)
  • 59.59 (a)
frmd4bb 37
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F07C6.4 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToMany
Species with no ortholog for FRMD4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMD4B Gene

ENSEMBL:
Gene Tree for FRMD4B (if available)
TreeFam:
Gene Tree for FRMD4B (if available)

Paralogs for FRMD4B Gene

Paralogs for FRMD4B Gene

genes like me logo Genes that share paralogs with FRMD4B: view

Variants for FRMD4B Gene

Sequence variations from dbSNP and Humsavar for FRMD4B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs767285 -- 69,352,935(+) TTGCC(A/G)AGTGT intron-variant
rs767286 -- 69,353,134(+) GAGCA(C/G)GGGAA intron-variant
rs881031 -- 69,357,705(-) TGGTG(C/T)GTCTG intron-variant
rs900666 -- 69,376,872(-) TTTTG(A/T)TGTCC intron-variant
rs900667 -- 69,376,865(-) GTCCC(A/G)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD4B Gene

Variant ID Type Subtype PubMed ID
nsv876933 CNV Loss 21882294
nsv237526 CNV Loss 16902084
nsv876935 CNV Gain 21882294
esv2667894 CNV Deletion 23128226
nsv3864 CNV Insertion 18451855
esv2725384 CNV Deletion 23290073
esv2725386 CNV Deletion 23290073
esv269141 CNV Insertion 20981092
nsv520818 CNV Loss 19592680
esv2675880 CNV Deletion 23128226
esv2725387 CNV Deletion 23290073
esv2725388 CNV Deletion 23290073
esv1946491 CNV Deletion 18987734
esv2725389 CNV Deletion 23290073
nsv237596 CNV Loss 16902084
esv1002559 CNV Deletion 20482838
esv2725390 CNV Deletion 23290073
esv1435155 CNV Deletion 17803354
nsv237604 CNV Loss 16902084

Relevant External Links for FRMD4B Gene

HapMap Linkage Disequilibrium report
FRMD4B

Disorders for FRMD4B Gene

Relevant External Links for FRMD4B

Genetic Association Database (GAD)
FRMD4B
Human Genome Epidemiology (HuGE) Navigator
FRMD4B
genes like me logo Genes that share disorders with FRMD4B: view

No data available for UniProtKB/Swiss-Prot for FRMD4B Gene

Publications for FRMD4B Gene

  1. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. (PMID: 11445584) Klarlund J.K. … Czech M.P. (J. Biol. Chem. 2001) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 3 49

Products for FRMD4B Gene

Sources for FRMD4B Gene

Back to Top

Content