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Aliases for FRMD4B Gene

Aliases for FRMD4B Gene

  • FERM Domain Containing 4B 2 3 5
  • GRP1-Binding Protein GRSP1 3 4
  • 6030440G05Rik 3
  • KIAA1013 4
  • GRSP1 3

External Ids for FRMD4B Gene

Previous GeneCards Identifiers for FRMD4B Gene

  • GC03M069302

Summaries for FRMD4B Gene

Entrez Gene Summary for FRMD4B Gene

  • This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]

GeneCards Summary for FRMD4B Gene

FRMD4B (FERM Domain Containing 4B) is a Protein Coding gene. An important paralog of this gene is C1orf106.

UniProtKB/Swiss-Prot for FRMD4B Gene

  • Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD4B Gene

Genomics for FRMD4B Gene

Regulatory Elements for FRMD4B Gene

Enhancers for FRMD4B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FRMD4B on UCSC Golden Path with GeneCards custom track

Promoters for FRMD4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FRMD4B on UCSC Golden Path with GeneCards custom track

Genomic Location for FRMD4B Gene

69,168,782 bp from pter
69,542,583 bp from pter
373,802 bases
Minus strand

Genomic View for FRMD4B Gene

Genes around FRMD4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMD4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD4B Gene

Proteins for FRMD4B Gene

  • Protein details for FRMD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FERM domain-containing protein 4B
    Protein Accession:
    Secondary Accessions:
    • Q8TAI3

    Protein attributes for FRMD4B Gene

    1034 amino acids
    Molecular mass:
    118047 Da
    Quaternary structure:
    • Interacts with GRP1.
    • Sequence=BAA76857.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FRMD4B Gene


neXtProt entry for FRMD4B Gene

Proteomics data for FRMD4B Gene at MOPED

Post-translational modifications for FRMD4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD4B Gene

Domains & Families for FRMD4B Gene

Suggested Antigen Peptide Sequences for FRMD4B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FERM domain.
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with FRMD4B: view

No data available for Gene Families for FRMD4B Gene

Function for FRMD4B Gene

Molecular function for FRMD4B Gene

UniProtKB/Swiss-Prot Function:
Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity).

Phenotypes for FRMD4B Gene

genes like me logo Genes that share phenotypes with FRMD4B: view

Animal Model Products

CRISPR Products

miRNA for FRMD4B Gene

miRTarBase miRNAs that target FRMD4B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRMD4B Gene

Localization for FRMD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMD4B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for FRMD4B Gene COMPARTMENTS Subcellular localization image for FRMD4B gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for FRMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FRMD4B: view

Pathways & Interactions for FRMD4B Gene

SuperPathways for FRMD4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD4B Gene


No data available for Pathways by source and SIGNOR curated interactions for FRMD4B Gene

Drugs & Compounds for FRMD4B Gene

No Compound Related Data Available

Transcripts for FRMD4B Gene

Unigene Clusters for FRMD4B Gene

FERM domain containing 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD4B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23
SP2: - - - - -
SP4: -

Relevant External Links for FRMD4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRMD4B Gene

mRNA expression in normal human tissues for FRMD4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FRMD4B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.2), Brain (20.4), Plasma (9.5), and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRMD4B Gene

SOURCE GeneReport for Unigene cluster for FRMD4B Gene Hs.709671

genes like me logo Genes that share expression patterns with FRMD4B: view

Protein tissue co-expression partners for FRMD4B Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FRMD4B Gene

Orthologs for FRMD4B Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD4B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FRMD4B 35
  • 91.59 (n)
  • 95.36 (a)
  • 95 (a)
(Mus musculus)
Mammalia Frmd4b 35
  • 86.73 (n)
  • 93.47 (a)
Frmd4b 16
Frmd4b 36
  • 93 (a)
(Pan troglodytes)
Mammalia FRMD4B 35
  • 99.55 (n)
  • 99.42 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Frmd4b 35
  • 87.4 (n)
  • 93.91 (a)
(Bos Taurus)
Mammalia FRMD4B 36
  • 93 (a)
(Monodelphis domestica)
Mammalia FRMD4B 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FRMD4B 36
  • 76 (a)
(Gallus gallus)
Aves FRMD4B 35
  • 76.49 (n)
  • 83.24 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia FRMD4B 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd4b 35
  • 68.34 (n)
  • 69.65 (a)
Str.2028 35
(Danio rerio)
Actinopterygii frmd4bb 35
  • 60.78 (n)
  • 59.59 (a)
frmd4ba 36
  • 55 (a)
frmd4bb 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea F07C6.4 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for FRMD4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMD4B Gene

Gene Tree for FRMD4B (if available)
Gene Tree for FRMD4B (if available)

Paralogs for FRMD4B Gene

Paralogs for FRMD4B Gene

genes like me logo Genes that share paralogs with FRMD4B: view

Variants for FRMD4B Gene

Sequence variations from dbSNP and Humsavar for FRMD4B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1038383 -- 69,376,854(-) TTGTT(A/G)TGGAA intron-variant
rs1038384 -- 69,376,853(-) TGTTG(C/G/T)GGAAA intron-variant
rs1038385 -- 69,376,012(-) ATCTC(C/T)AAATT intron-variant
rs1038386 -- 69,376,000(-) ATTTT(C/T)AATCC intron-variant
rs1038387 -- 69,375,850(-) GAGTT(C/G)CTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD4B Gene

Variant ID Type Subtype PubMed ID
nsv876933 CNV Loss 21882294
nsv237526 CNV Loss 16902084
nsv876935 CNV Gain 21882294
esv2667894 CNV Deletion 23128226
nsv3864 CNV Insertion 18451855
esv2725384 CNV Deletion 23290073
esv2725386 CNV Deletion 23290073
esv269141 CNV Insertion 20981092
nsv520818 CNV Loss 19592680
esv2675880 CNV Deletion 23128226
esv2725387 CNV Deletion 23290073
esv2725388 CNV Deletion 23290073
esv1946491 CNV Deletion 18987734
esv2725389 CNV Deletion 23290073
nsv237596 CNV Loss 16902084
esv1002559 CNV Deletion 20482838
esv2725390 CNV Deletion 23290073
esv1435155 CNV Deletion 17803354
nsv237604 CNV Loss 16902084

Variation tolerance for FRMD4B Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.67; 89.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FRMD4B Gene

Disorders for FRMD4B Gene

Relevant External Links for FRMD4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRMD4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMD4B Gene

Publications for FRMD4B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. (PMID: 11445584) Klarlund J.K. … Czech M.P. (J. Biol. Chem. 2001) 2 3 23
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 3
  5. Common variants in HSPB7 and FRMD4B associated with advanced heart failure. (PMID: 20124441) Cappola T.P. … Dorn G.W. (Circ Cardiovasc Genet 2010) 3

Products for FRMD4B Gene

Sources for FRMD4B Gene