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Aliases for FRMD4A Gene

Aliases for FRMD4A Gene

  • FERM Domain Containing 4A 2 3
  • FERM Domain Containing 4 2 3
  • FRMD4 3 4
  • FERM Domain-Containing Protein 4A 3
  • BA295P9.4 3
  • KIAA1294 4

External Ids for FRMD4A Gene

Previous Symbols for FRMD4A Gene

  • FRMD4

Summaries for FRMD4A Gene

GeneCards Summary for FRMD4A Gene

FRMD4A (FERM Domain Containing 4A) is a Protein Coding gene. GO annotations related to this gene include protein binding, bridging. An important paralog of this gene is C1orf106.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD4A Gene

Genomics for FRMD4A Gene

Genomic Location for FRMD4A Gene

Start:
13,643,706 bp from pter
End:
14,462,142 bp from pter
Size:
818,437 bases
Orientation:
Minus strand

Genomic View for FRMD4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRMD4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD4A Gene

Regulatory Elements for FRMD4A Gene

Proteins for FRMD4A Gene

  • Protein details for FRMD4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2Q2-FRM4A_HUMAN
    Recommended name:
    FERM domain-containing protein 4A
    Protein Accession:
    Q9P2Q2
    Secondary Accessions:
    • A7E2Y3
    • Q5T377

    Protein attributes for FRMD4A Gene

    Size:
    1039 amino acids
    Molecular mass:
    115458 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92532.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FRMD4A Gene

Proteomics data for FRMD4A Gene at MOPED

Post-translational modifications for FRMD4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRMD4A Gene

No data available for DME Specific Peptides for FRMD4A Gene

Domains for FRMD4A Gene

UniProtKB/Swiss-Prot:

FRM4A_HUMAN
Domain:
  • Contains 1 FERM domain.:
    • Q9P2Q2
genes like me logo Genes that share domains with FRMD4A: view

No data available for Gene Families for FRMD4A Gene

Function for FRMD4A Gene

Gene Ontology (GO) - Molecular Function for FRMD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030674 protein binding, bridging IEA --
genes like me logo Genes that share ontologies with FRMD4A: view

miRNA for FRMD4A Gene

miRTarBase miRNAs that target FRMD4A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FRMD4A Gene

Localization for FRMD4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMD4A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRMD4A Gene COMPARTMENTS Subcellular localization image for FRMD4A gene
Compartment Confidence
cytosol 3
cytoskeleton 2
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FRMD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with FRMD4A: view

Pathways for FRMD4A Gene

SuperPathways for FRMD4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090162 establishment of epithelial cell polarity IEA --
genes like me logo Genes that share ontologies with FRMD4A: view

No data available for Pathways by source for FRMD4A Gene

Transcripts for FRMD4A Gene

mRNA/cDNA for FRMD4A Gene

(20) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRMD4A Gene

FERM domain containing 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD4A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - - - -
SP11: - -
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:

ExUns: 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for FRMD4A Gene

GeneLoc Exon Structure for
FRMD4A
ECgene alternative splicing isoforms for
FRMD4A

Expression for FRMD4A Gene

mRNA expression in normal human tissues for FRMD4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRMD4A Gene

SOURCE GeneReport for Unigene cluster for FRMD4A Gene Hs.330463

genes like me logo Genes that share expressions with FRMD4A: view

Orthologs for FRMD4A Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRMD4A 36
  • 99.61 (n)
  • 99.9 (a)
FRMD4A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRMD4A 36
  • 89.81 (n)
  • 96.64 (a)
FRMD4A 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRMD4A 36
  • 92.67 (n)
  • 97.86 (a)
FRMD4A 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frmd4a 36
  • 89.42 (n)
  • 96.54 (a)
Frmd4a 16
Frmd4a 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRMD4A 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRMD4A 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frmd4a 36
  • 88.74 (n)
  • 95.96 (a)
chicken
(Gallus gallus)
Aves FRMD4A 37
  • 94 (a)
OneToOne
LOC419035 36
  • 83.63 (n)
  • 94.08 (a)
lizard
(Anolis carolinensis)
Reptilia FRMD4A 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9210 36
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd4a 36
  • 76.08 (n)
  • 88.61 (a)
Str.4039 36
zebrafish
(Danio rerio)
Actinopterygii FRMD4A 37
  • 81 (a)
OneToOne
si:ch211-220f12.1 36
  • 74.5 (n)
  • 83.38 (a)
worm
(Caenorhabditis elegans)
Secernentea F07C6.4 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for FRMD4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMD4A Gene

ENSEMBL:
Gene Tree for FRMD4A (if available)
TreeFam:
Gene Tree for FRMD4A (if available)

Paralogs for FRMD4A Gene

Paralogs for FRMD4A Gene

Selected SIMAP similar genes for FRMD4A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FRMD4A: view

Variants for FRMD4A Gene

Sequence variations from dbSNP and Humsavar for FRMD4A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3235 -- 13,907,609(-) TTCCT(C/T)GTCTG intron-variant
rs9473 -- 13,645,171(-) ACCAG(A/G)AGGGT utr-variant-3-prime
rs13005 -- 13,643,766(+) TAAAG(A/G)TACTA utr-variant-3-prime
rs721284 -- 13,947,949(+) ATTCC(A/G)GCACT intron-variant
rs729292 -- 13,686,338(-) GCTCA(A/G)AATTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FRMD4A Gene

Variant ID Type Subtype PubMed ID
nsv831789 CNV Gain+Loss 17160897
nsv831790 CNV Loss 17160897
dgv224e1 CNV Complex 17122850
esv988013 CNV Insertion 20482838
esv259917 OTHER Complex 20981092
esv25190 CNV Gain 19812545
nsv508569 CNV Loss 20534489
esv2653994 CNV Deletion 19546169
esv275072 CNV Gain+Loss 21479260
esv26313 CNV Gain 19812545
nsv516579 CNV Loss 19592680
esv32672 CNV Gain 17666407
nsv5842 CNV Loss 18451855
nsv528027 CNV Gain 19592680
nsv894887 CNV Loss 21882294
nsv516253 CNV Loss 19592680
dgv121e199 CNV Deletion 23128226
esv1329436 CNV Deletion 17803354
esv2663852 CNV Deletion 23128226
nsv5855 CNV Loss 18451855
nsv512149 CNV Loss 21212237
esv2657983 CNV Deletion 23128226
esv2733428 CNV Deletion 23290073
esv2674085 CNV Deletion 23128226
esv33167 CNV Loss 17666407
nsv507541 CNV Insertion 20534489

Relevant External Links for FRMD4A Gene

HapMap Linkage Disequilibrium report
FRMD4A

Disorders for FRMD4A Gene

Relevant External Links for FRMD4A

Genetic Association Database (GAD)
FRMD4A
Human Genome Epidemiology (HuGE) Navigator
FRMD4A
genes like me logo Genes that share disorders with FRMD4A: view

No data available for UniProtKB/Swiss-Prot for FRMD4A Gene

Publications for FRMD4A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  4. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F. … Pramstaller P.P. (Circ Cardiovasc Genet 2009) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for FRMD4A Gene

Sources for FRMD4A Gene

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