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Aliases for FRMD3 Gene

Aliases for FRMD3 Gene

  • FERM Domain Containing 3 2 3 5
  • Band 4.1-Like Protein 4O 3 4
  • Ovary Type Protein 4.1 3 4
  • EPB41L4O 3 4
  • 4.1O 3 4
  • Band 4.1-Like Protein 4 3
  • Protein 4.1O 3
  • EPB41LO 3
  • P410 3

External Ids for FRMD3 Gene

Previous GeneCards Identifiers for FRMD3 Gene

  • GC09M081315
  • GC09M083087
  • GC09M085047
  • GC09M085857
  • GC09M055687

Summaries for FRMD3 Gene

Entrez Gene Summary for FRMD3 Gene

  • The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for FRMD3 Gene

FRMD3 (FERM Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include cytoskeletal protein binding. An important paralog of this gene is EPB41L4A.

UniProtKB/Swiss-Prot for FRMD3 Gene

  • Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD3 Gene

Genomics for FRMD3 Gene

Regulatory Elements for FRMD3 Gene

Enhancers for FRMD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FRMD3 on UCSC Golden Path with GeneCards custom track

Promoters for FRMD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FRMD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FRMD3 Gene

83,242,990 bp from pter
83,538,546 bp from pter
295,557 bases
Minus strand

Genomic View for FRMD3 Gene

Genes around FRMD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD3 Gene

Proteins for FRMD3 Gene

  • Protein details for FRMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FERM domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A8MQB0
    • B4DN14
    • Q53EP2
    • Q5JV59
    • Q5VZA1
    • Q86WP8
    • Q8IZ44
    • Q8N3Y5
    • Q8N9L2

    Protein attributes for FRMD3 Gene

    597 amino acids
    Molecular mass:
    68772 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04321.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW62650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FRMD3 Gene


neXtProt entry for FRMD3 Gene

Proteomics data for FRMD3 Gene at MOPED

Post-translational modifications for FRMD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD3 Gene

Domains & Families for FRMD3 Gene

Suggested Antigen Peptide Sequences for FRMD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FERM domain.
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with FRMD3: view

No data available for Gene Families for FRMD3 Gene

Function for FRMD3 Gene

Molecular function for FRMD3 Gene

UniProtKB/Swiss-Prot Function:
Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.

Phenotypes for FRMD3 Gene

genes like me logo Genes that share phenotypes with FRMD3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRMD3 Gene

Localization for FRMD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMD3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FRMD3 Gene COMPARTMENTS Subcellular localization image for FRMD3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FRMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FRMD3: view

Pathways & Interactions for FRMD3 Gene

SuperPathways for FRMD3 Gene

No Data Available

Interacting Proteins for FRMD3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000303508 for FRMD3 Gene via STRING

Gene Ontology (GO) - Biological Process for FRMD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for FRMD3 Gene

Drugs & Compounds for FRMD3 Gene

No Compound Related Data Available

Transcripts for FRMD3 Gene

Unigene Clusters for FRMD3 Gene

FERM domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD3 Gene

No ASD Table

Relevant External Links for FRMD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRMD3 Gene

mRNA expression in normal human tissues for FRMD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRMD3 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.8) and Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for FRMD3 Gene

This gene is overexpressed in Retina (48.2) and Placenta (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRMD3 Gene

SOURCE GeneReport for Unigene cluster for FRMD3 Gene Hs.127535

mRNA Expression by UniProt/SwissProt for FRMD3 Gene

Tissue specificity: Ovary-specific.
genes like me logo Genes that share expression patterns with FRMD3: view

Protein tissue co-expression partners for FRMD3 Gene

Primer Products

Orthologs for FRMD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FRMD3 35
  • 93.64 (n)
  • 96.56 (a)
FRMD3 36
  • 96 (a)
(Mus musculus)
Mammalia Frmd3 35
  • 89.41 (n)
  • 91.6 (a)
Frmd3 16
Frmd3 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Frmd3 35
  • 87.63 (n)
  • 90.15 (a)
(Bos Taurus)
Mammalia FRMD3 36
  • 93 (a)
(Monodelphis domestica)
Mammalia FRMD3 36
  • 90 (a)
(Pan troglodytes)
Mammalia FRMD3 36
  • 100 (a)
(Gallus gallus)
Aves FRMD3 35
  • 81.05 (n)
  • 84.58 (a)
FRMD3 36
  • 84 (a)
(Anolis carolinensis)
Reptilia FRMD3 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd3 35
  • 74.2 (n)
  • 75.52 (a)
(Danio rerio)
Actinopterygii LOC100331256 35
  • 66.84 (n)
  • 65.96 (a)
frmd3 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5022 36
  • 27 (a)
Species with no ortholog for FRMD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FRMD3 Gene

Gene Tree for FRMD3 (if available)
Gene Tree for FRMD3 (if available)

Paralogs for FRMD3 Gene

(10) SIMAP similar genes for FRMD3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FRMD3: view

Variants for FRMD3 Gene

Sequence variations from dbSNP and Humsavar for FRMD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_048366 -
rs871790 -- 83,422,318(-) TGGAA(A/G)AGTCA intron-variant
rs942278 -- 83,291,151(-) CATCT(A/G)TCTGG intron-variant
rs942279 -- 83,291,015(-) TTTTT(A/T)AAAAA intron-variant
rs942280 -- 83,290,946(-) CTTTC(A/G)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD3 Gene

Variant ID Type Subtype PubMed ID
nsv6586 CNV Loss 18451855
nsv6588 CNV Insertion 18451855
esv1005171 CNV Insertion 20482838
esv2738667 CNV Deletion 23290073
nsv893512 CNV Gain 21882294
nsv6589 CNV Insertion 18451855
esv2664232 CNV Deletion 23128226
dgv1355e199 CNV Deletion 23128226

Variation tolerance for FRMD3 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FRMD3 Gene

Disorders for FRMD3 Gene

Relevant External Links for FRMD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRMD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMD3 Gene

Publications for FRMD3 Gene

  1. Molecular cloning and characterization of the protein 4.1O gene, a novel member of the protein 4.1 family with focal expression in ovary. (PMID: 12601556) Ni X. … Mao Y. (J. Hum. Genet. 2003) 2 3 4 23 67
  2. From single nucleotide polymorphism to transcriptional mechanism: a model for FRMD3 in diabetic nephropathy. (PMID: 23434934) Martini S. … Kretzler M. (Diabetes 2013) 3
  3. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3
  4. Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans. (PMID: 21698141) Freedman B.I. … Bowden D.W. (PLoS Genet. 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for FRMD3 Gene

Sources for FRMD3 Gene