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Aliases for FRMD3 Gene

Aliases for FRMD3 Gene

  • FERM Domain Containing 3 2 3
  • Band 4.1-Like Protein 4O 3 4
  • Ovary Type Protein 4.1 3 4
  • EPB41L4O 3 4
  • EPB41LO 3 6
  • 4.1O 3 4
  • FERM Domain-Containing Protein 3 3
  • Band 4.1-Like Protein 4 3
  • Protein 4.1O 3
  • P410 3

External Ids for FRMD3 Gene

Previous GeneCards Identifiers for FRMD3 Gene

  • GC09M081315
  • GC09M083087
  • GC09M085047
  • GC09M085857
  • GC09M055687

Summaries for FRMD3 Gene

Entrez Gene Summary for FRMD3 Gene

  • The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for FRMD3 Gene

FRMD3 (FERM Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include cytoskeletal protein binding. An important paralog of this gene is EPB41L4A.

UniProtKB/Swiss-Prot for FRMD3 Gene

  • Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD3 Gene

Genomics for FRMD3 Gene

Regulatory Elements for FRMD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FRMD3 Gene

Start:
83,242,990 bp from pter
End:
83,538,546 bp from pter
Size:
295,557 bases
Orientation:
Minus strand

Genomic View for FRMD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD3 Gene

Proteins for FRMD3 Gene

  • Protein details for FRMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2A2Y4-FRMD3_HUMAN
    Recommended name:
    FERM domain-containing protein 3
    Protein Accession:
    A2A2Y4
    Secondary Accessions:
    • A8MQB0
    • B4DN14
    • Q53EP2
    • Q5JV59
    • Q5VZA1
    • Q86WP8
    • Q8IZ44
    • Q8N3Y5
    • Q8N9L2

    Protein attributes for FRMD3 Gene

    Size:
    597 amino acids
    Molecular mass:
    68772 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04321.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW62650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FRMD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRMD3 Gene

Proteomics data for FRMD3 Gene at MOPED

Post-translational modifications for FRMD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD3 Gene

Domains for FRMD3 Gene

Suggested Antigen Peptide Sequences for FRMD3 Gene

Graphical View of Domain Structure for InterPro Entry

A2A2Y4

UniProtKB/Swiss-Prot:

FRMD3_HUMAN :
  • A2A2Y4
Domain:
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with FRMD3: view

No data available for Gene Families for FRMD3 Gene

Function for FRMD3 Gene

Molecular function for FRMD3 Gene

UniProtKB/Swiss-Prot Function: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.

Gene Ontology (GO) - Molecular Function for FRMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008092 cytoskeletal protein binding IEA --
genes like me logo Genes that share ontologies with FRMD3: view

Phenotypes for FRMD3 Gene

genes like me logo Genes that share phenotypes with FRMD3: view

Animal Model Products

CRISPR Products

miRNA for FRMD3 Gene

miRTarBase miRNAs that target FRMD3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FRMD3 Gene

Localization for FRMD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRMD3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRMD3 Gene COMPARTMENTS Subcellular localization image for FRMD3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FRMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0016021 integral component of membrane IEA --
GO:0019898 extrinsic component of membrane IEA --
genes like me logo Genes that share ontologies with FRMD3: view

Pathways for FRMD3 Gene

SuperPathways for FRMD3 Gene

No Data Available

Interacting Proteins for FRMD3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303508%0d%0a9606.ENSP00000215375%0d%0a9606.ENSP00000290299%0d%0a9606.ENSP00000285848%0d%0a
Selected Interacting proteins: ENSP00000303508 for FRMD3 Gene via STRING

Gene Ontology (GO) - Biological Process for FRMD3 Gene

None

No data available for Pathways by source for FRMD3 Gene

Transcripts for FRMD3 Gene

Unigene Clusters for FRMD3 Gene

FERM domain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRMD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FRMD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD3 Gene

No ASD Table

Relevant External Links for FRMD3 Gene

GeneLoc Exon Structure for
FRMD3
ECgene alternative splicing isoforms for
FRMD3

Expression for FRMD3 Gene

mRNA expression in normal human tissues for FRMD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRMD3 Gene

This gene is overexpressed in Heart - Left Ventricle (5.8) and Muscle - Skeletal (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRMD3 Gene

SOURCE GeneReport for Unigene cluster for FRMD3 Gene Hs.127535

mRNA Expression by UniProt/SwissProt for FRMD3 Gene

A2A2Y4-FRMD3_HUMAN
Tissue specificity: Ovary-specific.
genes like me logo Genes that share expressions with FRMD3: view

In Situ Assay Products

Orthologs for FRMD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRMD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRMD3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRMD3 35
  • 93.64 (n)
  • 96.56 (a)
FRMD3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frmd3 35
  • 89.41 (n)
  • 91.6 (a)
Frmd3 16
Frmd3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRMD3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frmd3 35
  • 87.63 (n)
  • 90.15 (a)
chicken
(Gallus gallus)
Aves FRMD3 35
  • 81.05 (n)
  • 84.58 (a)
FRMD3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRMD3 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd3 35
  • 74.2 (n)
  • 75.52 (a)
zebrafish
(Danio rerio)
Actinopterygii frmd3 36
  • 61 (a)
OneToOne
LOC100331256 35
  • 66.84 (n)
  • 65.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5022 36
  • 27 (a)
OneToMany
Species with no ortholog for FRMD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FRMD3 Gene

ENSEMBL:
Gene Tree for FRMD3 (if available)
TreeFam:
Gene Tree for FRMD3 (if available)

Paralogs for FRMD3 Gene

Selected SIMAP similar genes for FRMD3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FRMD3: view

Variants for FRMD3 Gene

Sequence variations from dbSNP and Humsavar for FRMD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs871790 -- 83,422,318(-) TGGAA(A/G)AGTCA intron-variant
rs942278 -- 83,291,151(-) CATCT(A/G)TCTGG intron-variant
rs942279 -- 83,291,015(-) TTTTT(A/T)AAAAA intron-variant
rs942280 -- 83,290,946(-) CTTTC(A/G)TTGAG intron-variant
rs942281 -- 83,290,871(-) TGTTA(C/T)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD3 Gene

Variant ID Type Subtype PubMed ID
nsv6586 CNV Loss 18451855
nsv6588 CNV Insertion 18451855
esv1005171 CNV Insertion 20482838
esv2738667 CNV Deletion 23290073
nsv893512 CNV Gain 21882294
nsv6589 CNV Insertion 18451855
esv2664232 CNV Deletion 23128226
dgv1355e199 CNV Deletion 23128226

Relevant External Links for FRMD3 Gene

HapMap Linkage Disequilibrium report
FRMD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMD3 Gene

Disorders for FRMD3 Gene

Relevant External Links for FRMD3

Genetic Association Database (GAD)
FRMD3
Human Genome Epidemiology (HuGE) Navigator
FRMD3
genes like me logo Genes that share disorders with FRMD3: view

No data available for UniProtKB/Swiss-Prot for FRMD3 Gene

Publications for FRMD3 Gene

  1. Molecular cloning and characterization of the protein 4.1O gene, a novel member of the protein 4.1 family with focal expression in ovary. (PMID: 12601556) Ni X. … Mao Y. (J. Hum. Genet. 2003) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. FRMD3, a novel putative tumour suppressor in NSCLC. (PMID: 17260017) Haase D. … Angel P. (Oncogene 2007) 3 4
  4. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. (PMID: 19252134) Pezzolesi M.G. … Krolewski A.S. (Diabetes 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for FRMD3 Gene

Sources for FRMD3 Gene

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