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FRMD3 Gene

protein-coding   GIFtS: 50
GCID: GC09M085857

FERM Domain Containing 3

  See FRMD3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FERM Domain Containing 31 2     EPB41LO2 5
Band 4.1-Like Protein 4O2 3     P4102
Ovary Type Protein 4.12 3     Band 4.1-Like Protein 42
4.1O2 3     FERM Domain-Containing Protein 32
EPB41L4O2 3     Protein 4.1O2

External Ids:    HGNC: 241251   Entrez Gene: 2570192   Ensembl: ENSG000001721597   OMIM: 6076195   UniProtKB: A2A2Y43   

Export aliases for FRMD3 gene to outside databases

Previous GC identifers: GC09M081315 GC09M083087 GC09M085047 GC09M055687


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FRMD3 Gene:
The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein
in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not
been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking
defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for FRMD3 Gene:
FRMD3 (FERM domain containing 3) is a protein-coding gene. Diseases associated with FRMD3 include diabetic nephropathy. GO annotations related to this gene include cytoskeletal protein binding. An important paralog of this gene is EPB41L5.

UniProtKB/Swiss-Prot: FRMD3_HUMAN, A2A2Y4
Function: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRMD3 gene promoter:
         USF1   Spz1   ATF-2   CREB   CRE-BP1   HEN1   E2F-1   E2F   USF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRMD3 promoter sequence
   Search Chromatin IP Primers for FRMD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRMD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32   Ensembl cytogenetic band:  9q21.32   HGNC cytogenetic band: 9q21.33

FRMD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRMD3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M085857:  view genomic region     (about GC identifiers)

Start:
85,857,905 bp from pter      End:
86,153,461 bp from pter
Size:
295,557 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FRMD3_HUMAN, A2A2Y4 (See protein sequence)
Recommended Name: FERM domain-containing protein 3  
Size: 597 amino acids; 68772 Da
Developmental stage: Expressed in skeletal muscle, lower levels in thymus and brain
Sequence caution: Sequence=BAC04321.1; Type=Erroneous initiation; Sequence=EAW62650.1; Type=Erroneous initiation;
Secondary accessions: A8MQB0 B4DN14 Q53EP2 Q5JV59 Q5VZA1 Q86WP8 Q8IZ44 Q8N3Y5 Q8N9L2
Alternative splicing: 5 isoforms:  A2A2Y4-1   A2A2Y4-2   A2A2Y4-3   A2A2Y4-4   A2A2Y4-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FRMD3: NX_A2A2Y4

Explore proteomics data for FRMD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FRMD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001231888.1  NP_001231889.1  NP_001231890.1  NP_001231891.1  NP_777598.3  

    ENSEMBL proteins: 
     ENSP00000328615   ENSP00000365617   ENSP00000365621   ENSP00000303508   ENSP00000412719  

    FRMD3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FRMD3

     
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    antibodies-online proteins for FRMD3 (3 products) 

     
    antibodies-online peptides for FRMD3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 11):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR000798 Ez/rad/moesin_like
     IPR019747 FERM_CS
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry A2A2Y4

    ProtoNet protein and cluster: A2A2Y4

    UniProtKB/Swiss-Prot: FRMD3_HUMAN, A2A2Y4
    Similarity: Contains 1 FERM domain


    Find genes that share domains with FRMD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRMD3_HUMAN, A2A2Y4
    Function: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008092cytoskeletal protein binding IEA--
         
    Find genes that share ontologies with FRMD3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FRMD3:
     Increased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FRMD3
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    miRNA
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    miRTarBase miRNAs that target FRMD3:
    hsa-mir-124-3p (MIRT022494)

    Block miRNA regulation of human, mouse, rat FRMD3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FRMD3:
    hsa-miR-3651 hsa-miR-129-3p hsa-miR-938 hsa-miR-129* hsa-miR-548c-3p hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidFRMD3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FRMD3_HUMAN, A2A2Y4: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    mitochondrion2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0016021integral component of membrane IEA--
    GO:0019898extrinsic component of membrane IEA--

    Find genes that share ontologies with FRMD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FRMD3
    Interactions:

        Search GeneGlobe Interaction Network for FRMD3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FRMD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FRMD3 gene (5 alternative transcripts): 
    NM_001244959.1  NM_001244960.1  NM_001244961.1  NM_001244962.1  NM_174938.5  

    Unigene Cluster for FRMD3:

    FERM domain containing 3
    Hs.127535  [show with all ESTs]
    Unigene Representative Sequence: NM_174938
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328788(uc004amq.1) ENST00000376434(uc022biz.1) ENST00000376438(uc004amr.1)
    ENST00000304195(uc022bja.1 uc004ams.2) ENST00000465485 ENST00000431299

    miRNA
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    Block miRNA regulation of human, mouse, rat FRMD3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FRMD3:
    hsa-miR-3651 hsa-miR-129-3p hsa-miR-938 hsa-miR-129* hsa-miR-548c-3p hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidFRMD3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FRMD3
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FRMD3
      QuantiTect SYBR Green Assays in human, mouse, rat FRMD3
      QuantiFast Probe-based Assays in human, mouse, rat FRMD3

    Additional mRNA sequence: 

    AK094281.1 AK223597.1 AK297722.1 AY137774.1 BC037253.1 BC041376.2 BX647549.1 EF560742.1 

    8 DOTS entries:

    DT.99996872  DT.433205  DT.100018807  DT.100018809  DT.121144399  DT.75180596  DT.75104450  DT.97837252 

    Selected AceView cDNA sequences (see all 83):

    BM715647 BU618212 BF110588 BX089823 AI540628 AA402220 AW162166 BM666832 
    W32094 BM873990 BC023560 BM674088 AI624361 AK094281 AI015267 BM874423 
    BI827685 AI984360 BU189443 BE221726 BC037253 CA419470 AI627259 D45564 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FRMD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACATTGGA
    FRMD3 Expression
    About this image


    FRMD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Rod Bipolar Cells Inner Nuclear Layer
             Retina
     
     Neurons
             Mature Rod Bipolar Cells Inner Nuclear Layer
    FRMD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRMD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127535

    UniProtKB/Swiss-Prot: FRMD3_HUMAN, A2A2Y4
    Tissue specificity: Ovary-specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FRMD3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frmd31 , 5 FERM domain containing 31, 5 89.41(n)1
    91.6(a)1
      4 (36.06 cM)5
    2425061  NM_172869.41  NP_766457.11 
     740134425 
    chicken
    (Gallus gallus)
    Aves FRMD31 FERM domain containing 3 81.05(n)
    84.58(a)
      427452  XM_003643038.2  XP_003643086.1 
    lizard
    (Anolis carolinensis)
    Reptilia FRMD36
    FERM domain containing 3
    81(a)
    1 ↔ 1
    2(42809720-42884101)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia frmd31 FERM domain containing 3 74.2(n)
    75.52(a)
      779965  NM_001079042.1  NP_001072510.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003312561 erythrocyte protein band 4.1-like 1-like 66.84(n)
    65.96(a)
      100331256  XM_002663231.2  XP_002663277.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50226
    --
    27(a)
    1 → many
    2L(10344442-10347706)


    ENSEMBL Gene Tree for FRMD3 (if available)
    TreeFam Gene Tree for FRMD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FRMD3 gene
    EPB41L52  EPB412  EPB41L12  PTPN32  EPB41L4B2  FARP12  PTPN42  FRMD52  
    FRMD72  EPB41L32  EPB41L4A2  FARP22  EPB41L22  
    10 SIMAP similar genes for FRMD3 using alignment to 2 protein entries:     FRMD3_HUMAN (see all proteins):
    FRMD5    EPB41L1    PTPN4    EPB41    EPB41L4A    EPB41L4B
    EPB41L2    EPB41L5    EPB41L3    FARP2

    Find genes that share paralogs with FRMD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FRMD3 (see all 6330)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863862171,2
    C--85857429(+) GTCTCC/TGTGGA 3 -- ds50010--------
    rs1412314631,2
    --85857517(+) ATTTGC/TAAGCC 3 -- ds50010--------
    rs70460381,2
    C,F,H--85857590(+) AACATT/GGAAAA 3 -- ds50014Minor allele frequency- G:0.03NS EA 418
    rs1469759871,2
    --85857684(+) CTTCTA/GTTCTT 3 -- ds50010--------
    rs78578221,2
    C,F,A,H--85857703(+) ATAACG/AGATAA 3 -- ds50015Minor allele frequency- A:0.23NS EA WA 536
    rs1441731941,2
    --85857712(+) AAGCTC/GTCTCA 3 -- ds50010--------
    rs70305341,2
    C,H--85857971(+) GCAAGG/TTTCCT 3 -- ut31 ese33Minor allele frequency- T:0.00NS EA 298
    rs583532291,2
    C,F--85858003(+) GCTGCC/TGAGCC 3 -- ut311Minor allele frequency- T:0.14WA 118
    rs736485181,2
    C,F--85858026(+) CCCACC/TGAACT 3 -- ut312Minor allele frequency- T:0.14WA 120
    rs1501746901,2
    --85858201(+) AGTAAA/GCAGCG 3 -- int10--------

    HapMap Linkage Disequilibrium report for FRMD3 (85857905 - 86107905 bp, first 250kb of FRMD3)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FRMD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1355e199CNV Deletion23128226
    esv2664232CNV Deletion23128226
    esv2738667CNV Deletion23290073
    esv1005171CNV Insertion20482838
    nsv6588CNV Insertion18451855
    nsv6589CNV Insertion18451855
    nsv6586CNV Loss18451855
    nsv893512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FRMD3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607619    OMIM disorders: --

    1 disease for FRMD3:    
    About MalaCards
    diabetic nephropathy


    Find genes that share disorders with FRMD3           About GenesLikeMe

    Genetic Association Database (GAD): FRMD3
    Human Genome Epidemiology (HuGE) Navigator: FRMD3 (5 documents)

    Export disorders for FRMD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FRMD3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with FRMD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the protein 4.1O gene, a novel member of the protein 4.1 family with focal expression in ovary. (PubMed id 12601556)1, 2, 3, 9 Ni X....Mao Y. (J. Hum. Genet. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. (PubMed id 20460425)1, 4 Maeda S....Nakamura Y. (Diabetes 2010)
    4. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. (PubMed id 19252134)1, 4 Pezzolesi M.G....Krolewski A.S. (Diabetes 2009)
    5. FRMD3, a novel putative tumour suppressor in NSCLC. (PubMed id 17260017)1, 2 Haase D.... Angel P. (Oncogene 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. From single nucleotide polymorphism to transcriptional mechanism: a model for FRMD3 in diabetic nephropathy. (PubMed id 23434934)1 Martini S....Kretzler M. (Diabetes 2013)
    8. Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans. (PubMed id 21698141)1 Freedman B.I....Bowden D.W. (PLoS Genet. 2011)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 257019 HGNC: 24125 AceView: FRMD3 Ensembl:ENSG00000172159 euGenes: HUgn257019
    ECgene: FRMD3 H-InvDB: FRMD3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FRMD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FRMD3 gene:
    Search GeneIP for patents involving FRMD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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