FRMD1 Gene
protein-coding GIFtS: 41
GCID: GC06M168456
|
|
FERM domain containing 1
| |
Aliases
for FRMD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FERM Domain Containing 11 2 | | FLJ226151 | | BA164L23.11 | | FLJ402601 | | DKFZp434O01171 | | FERM Domain-Containing Protein 12 | | FLJ001811 | | |
Export aliases for FRMD1 gene to outside databasesPrevious GC identifers: GC06M168138 GC06M168213 GC06M168275 GC06M165885 |
Summaries
for FRMD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FRMD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FRMD1 gene promoter:
STAT5A
Other transcription factors
Search SABiosciences Chromatin IP Primers for FRMD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRMD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27FRMD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M168456: view genomic region
(about GC identifiers)
Start:
|
168,456,425 bp from pter |
End:
|
168,482,237 bp from pter |
Size:
|
25,813 bases |
Orientation:
|
minus strand |
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Proteins
for FRMD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FRMD1_HUMAN, Q8N878 (See
protein sequence)Recommended Name: FERM domain-containing protein 1 Size: 549 amino acids; 62523 Da
Sequence caution: Sequence=CAB61397.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAI12329.1;Type=Erroneous gene model prediction;
Secondary accessions: B2RNV8 B3KUM6 Q5SZU7 Q9UFB0Alternative splicing: 2 isoforms: Q8N878-1 Q8N878-2 Explore the universe of human proteins at neXtProt for FRMD1: NX_Q8N878
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N878
FRMD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001116313.1 NP_079195.3
ENSEMBL proteins: ENSP00000283309 ENSP00000414115 ENSP00000427668 ENSP00000423552 ENSP00000424439 ENSP00000440078
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005856 | cytoskeleton |
IEA | -- |
FRMD1 for ontologies About GeneDecksing
FRMD1 Antibody Products:
Assay Products for FRMD1: |
Protein
Domains /
Families
for FRMD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FRMD1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N878ProtoNet protein and cluster: Q8N878 UniProtKB/Swiss-Prot: FRMD1_HUMAN, Q8N878Similarity: Contains 1 FERM domain |
Function
for FRMD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for FRMD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRMD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMD1 |
1 GenomeRNAi human phenotype for FRMD1:
|
Pathways & Interactions
for FRMD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FRMD1
|
Drugs & Compounds
for FRMD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FRMD1
Search CenterWatch for drugs/clinical trials and news about FRMD1
|
Transcripts
for FRMD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FRMD1 gene (2 alternative transcripts): NM_001122841.1 NM_024919.3 Unigene Cluster for FRMD1: FERM domain containing 1 Hs.266746 [show with all ESTs]Unigene Representative Sequence: AK07411010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283309(uc003qwo.4) ENST00000432403(uc003qwm.4) ENST00000358587
ENST00000440994(uc003qwn.4) ENST00000468647(uc011egs.2 uc011egt.2)
ENST00000509157 ENST00000336070 ENST00000506415 ENST00000511714 ENST00000537786
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FRMD1 (NM_024919) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FRMD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRMD1 |
Additional cDNA sequence: AK026268.1 AK074110.1 AK097179.1 AK097579.1 AK125963.1 AK303194.1 AK303407.1 AK316478.1 AL133077.1 BC137144.1 5 DOTS entries: DT.100017701 DT.70101526 DT.92045550 DT.101978337 DT.100748689 16 AceView cDNA sequences: AL133077 AK097579 AK125963 BQ893169 BQ027997 BF434538 NM_024919 BX282106 AW241593 AK097179 AW771525 BQ879914 AK074110 AK026268 AI766100 BG960897
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FRMD1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FRMD1
|
Expression
for FRMD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FRMD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTTGAGCC
About this image
See FRMD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FRMD1
SOURCE GeneReport for Unigene cluster: Hs.266746
SABiosciences Custom PCR Arrays for FRMD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRMD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FRMD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRMD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRMD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMD1 |
Orthologs
for FRMD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FRMD1 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FRMD11 |
FERM domain containing 1 |
67.53(n)
61(a) |
|
421562 XM_419603.3 XP_419603.3 |
lizard
(Anolis carolinensis) |
Reptilia |
FRMD16 |
-- |
44(a) |
1 ↔ 1 |
1(224831967-224860372) |
zebrafish
(Danio rerio) |
Actinopterygii |
BM776456.12 |
-- |
74.56(n) |
|
BM776456.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ex6 |
expanded |
8(a) |
1 → many |
2L(431227-448701) |
worm
(Caenorhabditis elegans) |
Secernentea |
frm-76 |
FERM domain (protein4.1-ezrin-radixin-moesin) fami... |
11(a) |
possible ortholog |
V(12302465-12306953) |
ENSEMBL Gene Tree for FRMD1 (if available)
TreeFam Gene Tree for FRMD1 (if available) |
Paralogs
for FRMD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FRMD1 gene
- FRMD62
2 SIMAP similar genes for FRMD1 using alignment to 4 protein entries: FRMD1_HUMAN (see all proteins):FLJ00181 FRMD6
FRMD1 for paralogs About GeneDecksing
|
Genomic Variants
for FRMD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FRMD1 (168456425 - 168482237 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 23 variations for FRMD1
15/22 CNVs (see all 22): 31312 5231 34566 8540 51850 51849 5234 53975 5235 8541 2667 34495 5233 7547 3654
1 Indel: 47053 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRMD1 |
|
Disorders
/ Diseases
for FRMD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FRMD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FRMD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FRMD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FRMD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FRMD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FRMD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FRMD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FRMD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FRMD1 gene:
Search GeneIP for patents involving FRMD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FRMD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FRMD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRMD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRMD1 | | | OriGene Protein Over-expression Lysate for FRMD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FRMD1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRMD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FRMD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRMD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRMD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRMD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRMD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRMD1 |
| |
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| |  |  |  |  | | | | |
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 | | | FRMD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRMD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for FRMD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRMD1 |
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