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Aliases for FRMD1 Gene

Aliases for FRMD1 Gene

  • FERM Domain Containing 1 2 3 5
  • BA164L23.1 3

External Ids for FRMD1 Gene

Previous GeneCards Identifiers for FRMD1 Gene

  • GC06M168138
  • GC06M168213
  • GC06M168275
  • GC06M168456
  • GC06M165885

Summaries for FRMD1 Gene

GeneCards Summary for FRMD1 Gene

FRMD1 (FERM Domain Containing 1) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway. An important paralog of this gene is FRMD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD1 Gene

Genomics for FRMD1 Gene

Regulatory Elements for FRMD1 Gene

Enhancers for FRMD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FRMD1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FRMD1 gene promoter:

Genomic Location for FRMD1 Gene

168,055,745 bp from pter
168,101,514 bp from pter
45,770 bases
Minus strand

Genomic View for FRMD1 Gene

Genes around FRMD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD1 Gene

Proteins for FRMD1 Gene

  • Protein details for FRMD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FERM domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RNV8
    • B3KUM6
    • Q5SZU7
    • Q9UFB0

    Protein attributes for FRMD1 Gene

    549 amino acids
    Molecular mass:
    62523 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB61397.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI12329.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FRMD1 Gene


neXtProt entry for FRMD1 Gene

Proteomics data for FRMD1 Gene at MOPED

Post-translational modifications for FRMD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRMD1 Gene

No data available for DME Specific Peptides for FRMD1 Gene

Domains & Families for FRMD1 Gene

Suggested Antigen Peptide Sequences for FRMD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FERM domain.
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with FRMD1: view

No data available for Gene Families for FRMD1 Gene

Function for FRMD1 Gene

genes like me logo Genes that share phenotypes with FRMD1: view

Animal Model Products

CRISPR Products

miRNA for FRMD1 Gene

miRTarBase miRNAs that target FRMD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRMD1 Gene

Localization for FRMD1 Gene

Subcellular locations from

Jensen Localization Image for FRMD1 Gene COMPARTMENTS Subcellular localization image for FRMD1 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FRMD1 Gene

Pathways & Interactions for FRMD1 Gene

SuperPathways for FRMD1 Gene

Superpath Contained pathways
1 Hippo signaling pathway
genes like me logo Genes that share pathways with FRMD1: view

Pathways by source for FRMD1 Gene

1 KEGG pathway for FRMD1 Gene

Interacting Proteins for FRMD1 Gene

Gene Ontology (GO) - Biological Process for FRMD1 Gene


No data available for SIGNOR curated interactions for FRMD1 Gene

Drugs & Compounds for FRMD1 Gene

No Compound Related Data Available

Transcripts for FRMD1 Gene

Unigene Clusters for FRMD1 Gene

FERM domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - -

Relevant External Links for FRMD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRMD1 Gene

mRNA expression in normal human tissues for FRMD1 Gene

mRNA differential expression in normal tissues according to GTEx for FRMD1 Gene

This gene is overexpressed in Stomach (x11.9), Colon - Transverse (x11.0), Kidney - Cortex (x6.5), Nerve - Tibial (x6.3), and Testis (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FRMD1 Gene

SOURCE GeneReport for Unigene cluster for FRMD1 Gene Hs.266746

genes like me logo Genes that share expression patterns with FRMD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FRMD1 Gene

Orthologs for FRMD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FRMD1 35
  • 71.08 (n)
  • 60.46 (a)
FRMD1 36
  • 63 (a)
(Canis familiaris)
Mammalia FRMD1 35
  • 77.35 (n)
  • 70.33 (a)
-- 36
  • 47 (a)
-- 36
  • 72 (a)
(Pan troglodytes)
Mammalia FRMD1 35
  • 98.47 (n)
  • 97.32 (a)
FRMD1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Frmd1 35
  • 74.7 (n)
  • 67.56 (a)
(Monodelphis domestica)
Mammalia FRMD1 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 4 (a)
(Gallus gallus)
Aves FRMD1 36
  • 49 (a)
(Anolis carolinensis)
Reptilia FRMD1 36
  • 46 (a)
(Danio rerio)
Actinopterygii FRMD1 (1 of 2) 36
  • 39 (a)
FRMD1 (2 of 2) 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta ex 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea frm-7 36
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for FRMD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FRMD1 Gene

Gene Tree for FRMD1 (if available)
Gene Tree for FRMD1 (if available)

Paralogs for FRMD1 Gene

Paralogs for FRMD1 Gene

(2) SIMAP similar genes for FRMD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FRMD1: view

Variants for FRMD1 Gene

Sequence variations from dbSNP and Humsavar for FRMD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs902393 - 168,062,944(+) GGGAC(A/G)ACCTT nc-transcript-variant, reference, missense
rs1548349 - 168,059,165(+) GACCT(C/G/T)GGTGC nc-transcript-variant, reference, missense
rs1109191 -- 168,095,070(+) AGAGG(A/G)ACTTG intron-variant
rs1387921 -- 168,069,038(-) GTTAC(C/T)GATGA intron-variant
rs6455478 -- 168,083,791(+) CTGGC(A/C/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD1 Gene

Variant ID Type Subtype PubMed ID
esv2422263 CNV Duplication 17116639
dgv27e196 CNV Duplication 17116639
dgv217e55 CNV Gain 17911159
dgv2034e1 CNV Complex 17122850
nsv830865 CNV Gain 17160897
dgv218e55 CNV Gain 17911159
nsv515568 CNV Gain+Loss 19592680
esv32818 CNV Gain 17666407
dgv791n27 CNV Gain 19166990
dgv2035e1 CNV Complex 17122850
nsv8004 CNV Gain 18304495
esv23528 CNV Gain+Loss 19812545
nsv442020 CNV CNV 18776908
dgv61n64 CNV Gain 17921354
nsv509173 CNV Insertion 20534489
nsv886961 CNV Loss 21882294
nsv886962 CNV Loss 21882294
nsv886972 CNV Loss 21882294
dgv7041n71 CNV Loss 21882294
dgv7042n71 CNV Loss 21882294
nsv830866 CNV Gain 17160897
dgv7043n71 CNV Loss 21882294
esv2733274 CNV Deletion 23290073
esv2733275 CNV Deletion 23290073
esv2733276 CNV Deletion 23290073
esv2733277 CNV Deletion 23290073
nsv464201 CNV Loss 19166990
esv2733278 CNV Deletion 23290073
esv2733279 CNV Deletion 23290073
esv2733280 CNV Deletion 23290073
esv2733281 CNV Deletion 23290073
esv2663321 CNV Deletion 23128226
esv2670695 CNV Deletion 23128226
esv2733282 CNV Deletion 23290073
esv2733283 CNV Deletion 23290073
esv2212981 CNV Deletion 18987734
esv2733285 CNV Deletion 23290073
nsv350028 CNV Loss 16902084
esv1194949 CNV Deletion 17803354
esv2733286 CNV Deletion 23290073
esv2258411 CNV Deletion 18987734
esv999492 CNV Deletion 20482838
esv2733287 CNV Deletion 23290073
esv1591785 CNV Deletion 17803354
esv2733288 CNV Deletion 23290073
esv2733289 CNV Deletion 23290073
esv2733290 CNV Deletion 23290073

Variation tolerance for FRMD1 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FRMD1 Gene

Disorders for FRMD1 Gene

Relevant External Links for FRMD1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRMD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMD1 Gene

Publications for FRMD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits. (PMID: 23527680) Ebejer J.L. … Medland S.E. (Twin Res Hum Genet 2013) 3
  3. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FRMD1 Gene

Sources for FRMD1 Gene