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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FRK Gene

protein-coding   GIFtS: 62
GCID: GC06M116308

fyn-related kinase

(Previous name: PTK5 protein tyrosine kinase 5 )
(Previous symbol: PTK5)
 Explore 10 diseases affiliated with
FRK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FRK    

Aliases
for FRK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fyn-Related Kinase1 2 3     Nuclear Tyrosine Protein Kinase RAK2 3
RAK1 2 3 5     Protein-Tyrosine Kinase 52 3
PTK51 2 3     EC 2.7.10.23 8
GTK1 2 5     Tyrosine-Protein Kinase FRK2
PTK5 Protein Tyrosine Kinase 51 2     EC 2.7.108

External Ids:    HGNC: 39551   Entrez Gene: 24442   Ensembl: ENSG000001118167   OMIM: 6065735   UniProtKB: P426853   

Export aliases for FRK gene to outside databases

Previous GC identifers: GC06M116098 GC06M116285 GC06M116369 GC06M113842


Summaries
for FRK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FRK:
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear
protein and may function during G1 and S phase of the cell cycle and suppress growth. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FRK_HUMAN, P42685
Function: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN
protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and
degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor

Gene Wiki entry for FRK (Fyn-related kinase)


Genomic Views
for FRK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FRK gene promoter:
         HFH-1   YY1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FRK promoter sequence
   Search SABiosciences Chromatin IP Primers for FRK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21-q22.3   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q21-q22.3

FRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M116308:  view genomic region     (about GC identifiers)

Start:
 116,262,693 bp from pter      End:
 116,381,921 bp from pter
Size:
 119,229 bases      Orientation:
 minus strand

Proteins
for FRK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FRK_HUMAN, P42685 (See protein sequence)
Recommended Name: Tyrosine-protein kinase FRK  
Size: 505 amino acids; 58254 Da
Subunit: Interacts (via the SH3-domain) with PTEN. Interacts with RB1
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the
cell periphery
Secondary accessions: Q13128 Q9NTR5

Explore the universe of human proteins at neXtProt for FRK: NX_P42685

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P42685

    • 4/10 DME Specific Peptides for FRK (P42685) (see all 10)
     KWTAPEA  RDLAARN  FLIRESE  GQFGEVW 

    FRK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002022.1  
    ENSEMBL proteins: 
     ENSP00000357615   ENSP00000443075  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant FRK Protein
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    OriGene Protein Over-expression Lysate: FRK
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    Novus Biologicals FRK Proteins
    Novus Biologicals FRK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FRK

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS7510261
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--


    FRK for ontologies           About GeneDecksing



    FRK Antibody Products: 
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    Uscn ELISAs and CLIAs for FRK

    Protein Domains /
    Families
    for FRK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FRK for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P42685

    ProtoNet protein and cluster: P42685

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FRK_HUMAN, P42685
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Function
    for FRK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FRK_HUMAN, P42685
    Function: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN
    protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and
    degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRK
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate FRK (see all 23):
    hsa-miR-30c hsa-miR-30d hsa-miR-421 hsa-miR-4275 hsa-miR-103a hsa-miR-30a hsa-miR-330-3p hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmid: FRK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRK (see all 7)
    OriGene shRNA RFP: FRK
    OriGene siRNA: FRK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FRK

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRK (see all 4)
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI19345329
    GO:0005524ATP binding IEA--


    FRK for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FRK:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Frktm1Liu for FRK
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Frk):
     homeostasis/metabolism  tumorigenesis 

    FRK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FRK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FRK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/24 Interacting proteins for FRK (P426851, 2, 3 ENSP000003576154) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604841, 3, ENSP000003610214EBI-1383583,EBI-696162 I2D: score=2 STRING: ENSP00000361021
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908059 I2D: score=1 STRING: ENSP00000365312
    RB1P064001, 3, ENSP000002671634EBI-1383583,EBI-491274 I2D: score=4 STRING: ENSP00000267163
    RAC1P630002, 3, ENSP000003484614MINT-4507979 I2D: score=1 STRING: ENSP00000348461
    DTX4Q9Y2E63I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS7696183
    GO:0008285negative regulation of cell proliferation TAS7664264
    GO:0030154cell differentiation IEA--


    FRK for ontologies           About GeneDecksing



    Drugs & Compounds
    for FRK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FRK for compounds           About GeneDecksing

    EMD Millipore small molecules for FRK:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FRK

    2 HMDB Compounds for FRK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    1 Novoseek chemical compound relationship for FRK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 59.8 12 15611931 (3), 8760296 (1), 19652529 (1), 20157399 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about FRK 

    Transcripts
    for FRK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FRK gene: 
    NM_002031.2  

    Unigene Cluster for FRK:

    Fyn-related kinase
    Hs.89426  [show with all ESTs]
    Unigene Representative Sequence: NM_002031
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368626(uc003pwi.1) ENST00000538210

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRK
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate FRK (see all 23):
    hsa-miR-30c hsa-miR-30d hsa-miR-421 hsa-miR-4275 hsa-miR-103a hsa-miR-30a hsa-miR-330-3p hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmid: FRK 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRK (see all 7)
    OriGene shRNA RFP: FRK
    OriGene siRNA: FRK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRK
    Clone
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    GenScript: all cDNA clones in your preferred vector: FRK (NM_002031)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRK

    Additional cDNA sequence: 

    AK302264.1 AK313314.1 BC012916.1 U00803.1 U22322.1 

    4 DOTS entries:

    DT.405693  DT.100748389  DT.100017306  DT.121389756 

    14 AceView cDNA sequences:

    BX279578 BC012916 NM_002031 U00803 BG403053 AW167319 BU561067 BM833058 
    BM787693 BX494753 U22322 BQ310745 BG290970 BE932988 

    GeneLoc Exon Structure


    Expression
    for FRK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FRK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTATGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FRK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal Collecting Duct SystemKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FRK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FRK

    SOURCE GeneReport for Unigene cluster: Hs.89426

    UniProtKB/Swiss-Prot: FRK_HUMAN, P42685
    Tissue specificity: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver,
    kidney, breast and colon

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    In Situ
    Assay Products:     
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    Orthologs
    for FRK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FRK gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FRK1 fyn-related kinase 71.87(n)
    72.41(a)    		   421747  XM_419779.3  XP_419779.3 
    lizard
    (Anolis carolinensis)    		 Reptilia FRK6
    		 --
    		 69(a)
    		 1 ↔ 1
    		 1(186458972-186507299)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5675491 tyrosine-protein kinase FRK-like 63.05(n)
    65.19(a)    		   567549  XM_003200656.1  XP_003200704.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Src64B3
    Src42A1    		 ring canal formation protein tyrosine kinase3
    Src oncogene at 42A1    		 48(a)3
    59.36(n)1
    63.6(a)1    		   64B123
    355241  NM_165452.11  NP_724441.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea src-13
    src-21    		 Expression: vulva, anus, mu_bod, pharyngeal
    muscle, more3
    Protein SRC-21    		 44(a)
    (best of 20)3
    58.75(n)1
    56.11(a)1    		   I(1567610-1580076)3
    1732961  NM_061101.31  NP_493502.11 


    ENSEMBL Gene Tree for FRK (if available)
    TreeFam Gene Tree for FRK (if available) 

    Paralogs
    for FRK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FRK gene
    TEC2  LCK2  BLK2  FGR2  ITK2  LYN2  TXK2  HCK2  
    YES12  PTK62  SRC2  ABL12  FYN2  BMX2  ABL22  SRMS2  
    BTK2  
    18/86 SIMAP similar genes for FRK using alignment to 2 protein entries:     FRK_HUMAN (see all proteins) (see all similar genes):
    FYN    HCK    SRC    LYN    BLK    YES1
    ABL1    FGR    PTK6    TNK2    TXK    tec
    BCR/ABL fusion    FES    ABL2    BTK kinase deficient isoform 6    EPHA4    EPHB4

    FRK for paralogs           About GeneDecksing



    Genomic Variants
    for FRK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1832 NCBI SNPs in FRK are shown (see all 1832)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1388235591,2
    		--116262263(+) AATGCC/TCATCA 1 -- ds50010--------
    rs1493407421,2
    		--116262270(+) ATCAAC/TGATAG 1 -- ds50010--------
    rs1899370621,2
    		--116262325(+) GCAGCA/CATAAA 1 -- ds50010--------
    rs4767011,2
    		C,--116262388(-) TTGTTG/AAGAAT 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs58793561,2
    		C,--116262473(+) GACAC-/AAGGAGGG 1 -- ds50010--------
    rs1441477241,2
    		--116262558(+) GTAGAC/TGACGG 1 -- ds50010--------
    rs21051711,2
    		C,F,O,A,H,--116262857(-) CAAAAC/TGGATG 1 -- ut31 ese314Minor allele frequency- T:0.15NA NS EA WA CSA 802
    rs1821087821,2
    		--116262862(+) GTTTTA/GCAACC 1 -- ut310--------
    rs4955651,2
    		C,F,O,A,H,--116262976(+) ACTTCA/GTTTTC 1 -- ut3132Minor allele frequency- G:0.30EA NA NS WA CSA 4223
    rs1871066941,2
    		--116263079(+) AGTTAC/TAGGAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FRK (116262693 - 116381921 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for FRK
         1 CNV: 93972
         1 Indel: 99675
    Human Gene Mutation Database (HGMD): FRK

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRK
    DNA2.0 Custom Variant and Variant Library Synthesis for FRK

    Disorders / Diseases
    for FRK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FRK for disorders           About GeneDecksing

    OMIM gene information: 606573    OMIM disorders: --

    10 diseases for FRK:    About MalaCards
    age related macular degeneration    euthyroid sick syndrome    macular degeneration    alzheimer's disease
    pharyngitis    retinoblastoma    breast cancer    obesity
    leukemia    neuronitis

    1 Novoseek disease relationship for FRK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 19652529 (2)

    Genetic Association Database (GAD): FRK
    Human Genome Epidemiology (HuGE) Navigator: FRK (5 documents)

    Export disorders for FRK gene to outside databases

    Publications
    for FRK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FRK gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with FRK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase- encoding gene. (PubMed id 7510261)1, 2, 3, 9 Lee J.... Scadden D.T. (1994)
    2. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. (PubMed id 19345329)1, 2 Yim E.K....Lin S.Y. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset. (PubMed id 12750000)1, 4 Ohnuma T....Arai H. (2003)
    5. The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. (PubMed id 7664264)1, 2 Craven R.J....Liu E.T. (1995)
    6. Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. (PubMed id 7696183)1, 2 Cance W.G.... Liu E.T. (1994)
    7. Novel protein kinases expressed in human breast cancer. (PubMed id 8099900)1, 2 Cance W.G.... Liu E.T. (1993)
    8. RAKing in AKT: a tumor suppressor function for the in tracellular tyrosine kinase FRK. (PubMed id 19652529)2, 9 Brauer P.M. and Tyner A.L. (2009)
    9. Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. (PubMed id 12725532)1, 9 Serfas M.S. and Tyner A.L. (2003)
    10. Comprehensive analysis of interactions between the Src -associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PubMed id 22745667)1 Asbach B....Wagner R. (2012)

    External Searches for FRK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing FRK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2444 HGNC: 3955 AceView: FRK Ensembl:ENSG00000111816 euGenes: HUgn2444
    ECgene: FRK H-InvDB: FRK

    Other Databases showing FRK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FRK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FRK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FRK Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FRK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FRK gene:
    Search GeneIP for patents involving FRK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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