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Aliases for FRK Gene

Aliases for FRK Gene

  • Fyn-Related Src Family Tyrosine Kinase 2 3
  • RAK 3 4 6
  • Nuclear Tyrosine Protein Kinase RAK 3 4
  • PTK5 Protein Tyrosine Kinase 5 2 3
  • Protein-Tyrosine Kinase 5 3 4
  • Fyn-Related Kinase 2 3
  • EC 2.7.10.2 4 63
  • PTK5 3 4
  • GTK 3 6
  • Tyrosine-Protein Kinase FRK 3
  • FYN-Related Kinase 4
  • EC 2.7.10 63

External Ids for FRK Gene

Previous HGNC Symbols for FRK Gene

  • PTK5

Previous GeneCards Identifiers for FRK Gene

  • GC06M116098
  • GC06M116285
  • GC06M116308
  • GC06M116369
  • GC06M113842

Summaries for FRK Gene

Entrez Gene Summary for FRK Gene

  • The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for FRK Gene

FRK (Fyn-Related Src Family Tyrosine Kinase) is a Protein Coding gene. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for FRK Gene

  • Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on Tyr-336, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Gene Wiki entry for FRK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRK Gene

Genomics for FRK Gene

Regulatory Elements for FRK Gene

Genomic Location for FRK Gene

Start:
115,931,149 bp from pter
End:
116,100,730 bp from pter
Size:
169,582 bases
Orientation:
Minus strand

Genomic View for FRK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRK Gene

Proteins for FRK Gene

  • Protein details for FRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42685-FRK_HUMAN
    Recommended name:
    Tyrosine-protein kinase FRK
    Protein Accession:
    P42685
    Secondary Accessions:
    • B4DY49
    • Q13128
    • Q9NTR5

    Protein attributes for FRK Gene

    Size:
    505 amino acids
    Molecular mass:
    58254 Da
    Quaternary structure:
    • Interacts (via the SH3-domain) with PTEN. Interacts with RB1.

    Alternative splice isoforms for FRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRK Gene

Proteomics data for FRK Gene at MOPED

Selected DME Specific Peptides for FRK Gene

Post-translational modifications for FRK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FRK Gene

Gene Families for FRK Gene

HGNC:
  • SH2D :SH2 domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for FRK Gene

Graphical View of Domain Structure for InterPro Entry

P42685

UniProtKB/Swiss-Prot:

FRK_HUMAN :
  • P42685
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FRK: view

Function for FRK Gene

Molecular function for FRK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on Tyr-336, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Enzyme Numbers (IUBMB) for FRK Gene

Gene Ontology (GO) - Molecular Function for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 19345329
genes like me logo Genes that share ontologies with FRK: view
genes like me logo Genes that share phenotypes with FRK: view

Animal Models for FRK Gene

MGI Knock Outs for FRK:

miRNA for FRK Gene

miRTarBase miRNAs that target FRK

No data available for Transcription Factor Targeting and HOMER Transcription for FRK Gene

Localization for FRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRK Gene

Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRK Gene COMPARTMENTS Subcellular localization image for FRK gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 7510261
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with FRK: view

Pathways for FRK Gene

SuperPathways for FRK Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 7696183
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0008285 negative regulation of cell proliferation TAS 7664264
GO:0016477 cell migration IBA --
GO:0018108 peptidyl-tyrosine phosphorylation --
genes like me logo Genes that share ontologies with FRK: view

No data available for Pathways by source for FRK Gene

Compounds for FRK Gene

(2) HMDB Compounds for FRK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Novoseek inferred chemical compound relationships for FRK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 59.8 9
genes like me logo Genes that share compounds with FRK: view

Transcripts for FRK Gene

mRNA/cDNA for FRK Gene

(14) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(8) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRK Gene

Fyn-related kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRK Gene

No ASD Table

Relevant External Links for FRK Gene

GeneLoc Exon Structure for
FRK
ECgene alternative splicing isoforms for
FRK

Expression for FRK Gene

mRNA expression in normal human tissues for FRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRK Gene

This gene is overexpressed in Artery - Tibial (4.2) and Artery - Coronary (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FRK Gene

SOURCE GeneReport for Unigene cluster for FRK Gene Hs.89426

mRNA Expression by UniProt/SwissProt for FRK Gene

P42685-FRK_HUMAN
Tissue specificity: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
genes like me logo Genes that share expressions with FRK: view

Orthologs for FRK Gene

This gene was present in the common ancestor of animals.

Orthologs for FRK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRK 35
  • 99.8 (n)
  • 99.41 (a)
FRK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRK 35
  • 87.63 (n)
  • 88.29 (a)
FRK 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRK 35
  • 82.59 (n)
  • 81.85 (a)
FRK 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frk 35
  • 87.04 (n)
  • 89.68 (a)
Frk 16
Frk 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRK 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frk 35
  • 85.38 (n)
  • 88.69 (a)
chicken
(Gallus gallus)
Aves FRK 35
  • 71.31 (n)
  • 71.71 (a)
FRK 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRK 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frk 35
  • 66.6 (n)
  • 63.45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9440 35
zebrafish
(Danio rerio)
Actinopterygii fynrk 36
  • 36 (a)
OneToOne
LOC567549 35
  • 63.44 (n)
  • 65.64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006270 35
  • 59.87 (n)
  • 65.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta Src42A 35
  • 59.36 (n)
  • 63.6 (a)
Src42A 36
  • 57 (a)
OneToOne
Src64B 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea src-2 35
  • 58.78 (n)
  • 56.31 (a)
src-2 36
  • 50 (a)
OneToOne
F59A3.8 37
  • 32 (a)
F23C8.7 37
  • 32 (a)
ZK593.9 37
  • 26 (a)
C25A8.5 37
  • 33 (a)
kin-24 37
  • 26 (a)
R151.4 37
  • 38 (a)
src-1 37
  • 44 (a)
T21G5.1 37
  • 36 (a)
T25B9.4 37
  • 28 (a)
W01B6.5 37
  • 29 (a)
T14E8.1a 37
  • 38 (a)
F57B9.8 37
  • 31 (a)
C24G6.2a 37
  • 36 (a)
T14E8.1b 37
  • 38 (a)
R11E3.1 37
  • 32 (a)
C55C3.4 37
  • 33 (a)
kin-26 37
  • 28 (a)
Y69E1A.3 37
  • 33 (a)
C35E7.10a 37
  • 33 (a)
C24G6.2b 37
  • 36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14575 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3054 36
  • 49 (a)
OneToOne
Species with no ortholog for FRK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRK Gene

ENSEMBL:
Gene Tree for FRK (if available)
TreeFam:
Gene Tree for FRK (if available)

Paralogs for FRK Gene

Paralogs for FRK Gene

genes like me logo Genes that share paralogs with FRK: view

Variants for FRK Gene

Sequence variations from dbSNP and Humsavar for FRK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs475456 -- 116,098,128(+) ttttt(A/T)aaaga intron-variant
rs476701 -- 115,941,225(-) ttgtt(A/G)agaat downstream-variant-500B
rs484633 -- 115,973,691(-) GGTTT(C/T)GCCAT intron-variant
rs485652 -- 115,973,570(-) TTTTT(A/T)AAAAT intron-variant
rs485705 -- 115,970,992(-) aAGGT(G/T)AACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRK Gene

Variant ID Type Subtype PubMed ID
nsv886547 CNV Loss 21882294
nsv523972 CNV Gain 19592680
esv2732603 CNV Deletion 23290073
esv1229647 CNV Deletion 17803354
esv272013 CNV Insertion 20981092
esv273944 CNV Insertion 20981092
esv2528433 CNV Insertion 19546169
esv1334759 CNV Insertion 17803354

Relevant External Links for FRK Gene

HapMap Linkage Disequilibrium report
FRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRK Gene

Disorders for FRK Gene

(1) Novoseek inferred disease relationships for FRK Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for FRK

Genetic Association Database (GAD)
FRK
Human Genome Epidemiology (HuGE) Navigator
FRK
genes like me logo Genes that share disorders with FRK: view

No data available for UniProtKB/Swiss-Prot for FRK Gene

Publications for FRK Gene

  1. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase- encoding gene. (PMID: 7510261) Lee J. … Scadden D.T. (Gene 1994) 2 3 4 23
  2. The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. (PMID: 7664264) Craven R.J. … Liu E.T. (Cancer Res. 1995) 3 4
  3. Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. (PMID: 7696183) Cance W.G. … Liu E.T. (Cell Growth Differ. 1994) 3 4
  4. Novel protein kinases expressed in human breast cancer. (PMID: 8099900) Cance W.G. … Liu E.T. (Int. J. Cancer 1993) 3 4
  5. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. (PMID: 19345329) Yim E.-K. … Lin S.-Y. (Cancer Cell 2009) 3 4

Products for FRK Gene

  • Addgene plasmids for FRK

Sources for FRK Gene

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