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Aliases for FRK Gene

Aliases for FRK Gene

  • Fyn Related Src Family Tyrosine Kinase 2 3 5
  • Nuclear Tyrosine Protein Kinase RAK 3 4
  • PTK5 Protein Tyrosine Kinase 5 2 3
  • Protein-Tyrosine Kinase 5 3 4
  • Fyn-Related Kinase 2 3
  • EC 2.7.10.2 4 61
  • PTK5 3 4
  • RAK 3 4
  • Fyn-Related Src Family Tyrosine Kinase 2
  • Tyrosine-Protein Kinase FRK 3
  • FYN-Related Kinase 4
  • EC 2.7.10 61
  • GTK 3

External Ids for FRK Gene

Previous HGNC Symbols for FRK Gene

  • PTK5

Previous GeneCards Identifiers for FRK Gene

  • GC06M116098
  • GC06M116285
  • GC06M116308
  • GC06M116369
  • GC06M113842

Summaries for FRK Gene

Entrez Gene Summary for FRK Gene

  • The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for FRK Gene

FRK (Fyn Related Src Family Tyrosine Kinase) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGR.

UniProtKB/Swiss-Prot for FRK Gene

  • Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on Tyr-336, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Gene Wiki entry for FRK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRK Gene

Genomics for FRK Gene

Regulatory Elements for FRK Gene

Enhancers for FRK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G116015 1.1 Ensembl ENCODE 28.8 +84.0 83971 3.3 SOX13 PKNOX1 TFAP4 FOXA2 SAP130 ZNF644 RELA NCOR1 MAFK CREM FRK NT5DC1 FAM26F TPI1P3 PIR54414
GH06G116058 1.2 Ensembl ENCODE 19.5 +40.2 40164 3.3 PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 YY1 TCF12 SLC30A9 ZNF766 FRK NT5DC1 GC06M116052 GC06M116078
GH06G116010 1.2 Ensembl ENCODE 17.8 +88.3 88307 3.0 FOXA2 WRNIP1 ARID4B YY1 GATA2 ZNF143 FOS JUNB REST PPARG FRK TPI1P3 PIR54414
GH06G116008 1 Ensembl ENCODE 17.7 +91.8 91802 1.6 PKNOX1 CEBPG FEZF1 ZNF664 ZNF316 NFYB RELB FOS HLF CEBPB FRK TPI1P3 PIR54414
GH06G116034 0.4 Ensembl 31.9 +66.6 66628 0.2 BACH1 FRK TPI1P3 PIR54414
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FRK on UCSC Golden Path with GeneCards custom track

Genomic Location for FRK Gene

Chromosome:
6
Start:
115,931,149 bp from pter
End:
116,100,728 bp from pter
Size:
169,580 bases
Orientation:
Minus strand

Genomic View for FRK Gene

Genes around FRK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRK Gene

Proteins for FRK Gene

  • Protein details for FRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42685-FRK_HUMAN
    Recommended name:
    Tyrosine-protein kinase FRK
    Protein Accession:
    P42685
    Secondary Accessions:
    • B4DY49
    • Q13128
    • Q9NTR5

    Protein attributes for FRK Gene

    Size:
    505 amino acids
    Molecular mass:
    58254 Da
    Quaternary structure:
    • Interacts (via the SH3-domain) with PTEN. Interacts with RB1.

    Alternative splice isoforms for FRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRK Gene

Selected DME Specific Peptides for FRK Gene

P42685:
  • RDLAARN
  • KWTAPEA
  • IKSDVWSFGILL
  • FLIRESE
  • GQFGEVW
  • WEIDRNSI
  • GYIPSNYVA
  • AARNVLV
  • KSDVWSFG
  • PIYIITE

Post-translational modifications for FRK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FRK Gene

Suggested Antigen Peptide Sequences for FRK Gene

Graphical View of Domain Structure for InterPro Entry

P42685

UniProtKB/Swiss-Prot:

FRK_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FRK: view

Function for FRK Gene

Molecular function for FRK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on Tyr-336, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Enzyme Numbers (IUBMB) for FRK Gene

Gene Ontology (GO) - Molecular Function for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS,IBA --
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with FRK: view
genes like me logo Genes that share phenotypes with FRK: view

Animal Models for FRK Gene

MGI Knock Outs for FRK:

Animal Model Products

  • Taconic Biosciences Mouse Models for FRK

miRNA for FRK Gene

miRTarBase miRNAs that target FRK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRK Gene

Localization for FRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRK Gene

Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRK gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
lysosome 4
plasma membrane 3
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular TAS 7510261
GO:0005634 nucleus TAS 7696183
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FRK: view

Pathways & Interactions for FRK Gene

genes like me logo Genes that share pathways with FRK: view

Pathways by source for FRK Gene

Gene Ontology (GO) - Biological Process for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12837246
GO:0006468 protein phosphorylation TAS 7696183
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0008285 negative regulation of cell proliferation TAS 7664264
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with FRK: view

No data available for SIGNOR curated interactions for FRK Gene

Drugs & Compounds for FRK Gene

(4) Drugs for FRK Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma inhibitor, Target Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Stivarga Approved February 2013/ Approved September 2012 Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for FRK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with FRK: view

Transcripts for FRK Gene

mRNA/cDNA for FRK Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRK Gene

Fyn-related kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRK Gene

No ASD Table

Relevant External Links for FRK Gene

GeneLoc Exon Structure for
FRK
ECgene alternative splicing isoforms for
FRK

Expression for FRK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRK Gene

This gene is overexpressed in Artery - Tibial (x4.2) and Artery - Coronary (x4.0).

Protein differential expression in normal tissues from HIPED for FRK Gene

This gene is overexpressed in Urine (31.9), Monocytes (23.7), and Lung (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FRK Gene



Protein tissue co-expression partners for FRK Gene

NURSA nuclear receptor signaling pathways regulating expression of FRK Gene:

FRK

SOURCE GeneReport for Unigene cluster for FRK Gene:

Hs.89426

mRNA Expression by UniProt/SwissProt for FRK Gene:

P42685-FRK_HUMAN
Tissue specificity: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.

Evidence on tissue expression from TISSUES for FRK Gene

  • Liver(4.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FRK: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FRK Gene

Orthologs for FRK Gene

This gene was present in the common ancestor of animals.

Orthologs for FRK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRK 34 35
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia FRK 34 35
  • 87.63 (n)
mouse
(Mus musculus)
Mammalia Frk 34 16 35
  • 87.04 (n)
rat
(Rattus norvegicus)
Mammalia Frk 34
  • 85.38 (n)
oppossum
(Monodelphis domestica)
Mammalia FRK 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRK 34 35
  • 82.59 (n)
chicken
(Gallus gallus)
Aves FRK 34 35
  • 71.31 (n)
lizard
(Anolis carolinensis)
Reptilia FRK 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frk 34
  • 66.6 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC567549 34
  • 63.44 (n)
fynrk 35
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9440 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006270 34
  • 59.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Src42A 34 35
  • 59.36 (n)
Src64B 36
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea src-2 34 35
  • 58.78 (n)
src-1 36
  • 44 (a)
R151.4 36
  • 38 (a)
T14E8.1a 36
  • 38 (a)
T14E8.1b 36
  • 38 (a)
C24G6.2a 36
  • 36 (a)
C24G6.2b 36
  • 36 (a)
T21G5.1 36
  • 36 (a)
C25A8.5 36
  • 33 (a)
C35E7.10a 36
  • 33 (a)
C55C3.4 36
  • 33 (a)
Y69E1A.3 36
  • 33 (a)
F23C8.7 36
  • 32 (a)
F59A3.8 36
  • 32 (a)
R11E3.1 36
  • 32 (a)
F57B9.8 36
  • 31 (a)
W01B6.5 36
  • 29 (a)
kin-26 36
  • 28 (a)
T25B9.4 36
  • 28 (a)
kin-24 36
  • 26 (a)
ZK593.9 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3054 35
  • 49 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14575 34
Species where no ortholog for FRK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRK Gene

ENSEMBL:
Gene Tree for FRK (if available)
TreeFam:
Gene Tree for FRK (if available)

Paralogs for FRK Gene

Paralogs for FRK Gene

genes like me logo Genes that share paralogs with FRK: view

Variants for FRK Gene

Sequence variations from dbSNP and Humsavar for FRK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000012783 -- 116,090,745(+) CCACA(-/C)CCCCC intron-variant
rs1000018695 -- 116,061,982(+) AAGAA(-/AAAG)AAAGA intron-variant, upstream-variant-2KB
rs1000027326 -- 116,023,457(+) AAAAT(C/T)AGCAA intron-variant
rs1000100882 -- 116,022,183(+) AAAAC(A/C)TTCGC intron-variant
rs1000110943 -- 116,053,629(+) ATCAA(A/C/G)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRK Gene

Variant ID Type Subtype PubMed ID
esv1229647 CNV deletion 17803354
esv1334759 CNV insertion 17803354
esv2528433 CNV insertion 19546169
esv2732603 CNV deletion 23290073
esv3370056 CNV duplication 20981092
esv3418241 CNV duplication 20981092
esv3610465 CNV loss 21293372
esv3610466 CNV loss 21293372
nsv1029998 CNV loss 25217958
nsv1116557 OTHER inversion 24896259
nsv1132007 CNV deletion 24896259
nsv1142641 CNV deletion 24896259
nsv1152770 CNV deletion 26484159
nsv523972 CNV gain 19592680
nsv958343 CNV deletion 24416366
nsv981177 CNV duplication 23825009

Variation tolerance for FRK Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRK Gene

Human Gene Mutation Database (HGMD)
FRK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRK Gene

Disorders for FRK Gene

Relevant External Links for FRK

Genetic Association Database (GAD)
FRK
Human Genome Epidemiology (HuGE) Navigator
FRK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRK

No disorders were found for FRK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRK Gene

Publications for FRK Gene

  1. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase- encoding gene. (PMID: 7510261) Lee J. … Scadden D.T. (Gene 1994) 2 3 4 22 64
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 46 64
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  4. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. (PMID: 19345329) Yim E.-K. … Lin S.-Y. (Cancer Cell 2009) 3 4 64
  5. RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. (PMID: 19652529) Brauer P.M. … Tyner A.L. (Cell Cycle 2009) 4 22 64

Products for FRK Gene

Sources for FRK Gene

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