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FRK Gene

protein-coding   GIFtS: 62
GCID: GC06M116308

Fyn-Related Kinase

(Previous name: PTK5 protein tyrosine kinase 5)
(Previous symbol: PTK5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fyn-Related Kinase1 2 3     Protein-Tyrosine Kinase 52 3
PTK51 2 3     EC 2.7.10.23 8
RAK2 3 5     GTK2 5
PTK5 Protein Tyrosine Kinase 51 2     Tyrosine-Protein Kinase FRK2
Nuclear Tyrosine Protein Kinase RAK2 3     EC 2.7.108

External Ids:    HGNC: 39551   Entrez Gene: 24442   Ensembl: ENSG000001118167   OMIM: 6065735   UniProtKB: P426853   

Export aliases for FRK gene to outside databases

Previous GC identifers: GC06M116098 GC06M116285 GC06M116369 GC06M113842


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FRK Gene:
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear
protein and may function during G1 and S phase of the cell cycle and suppress growth. (provided by RefSeq, Jul
2008)

GeneCards Summary for FRK Gene:
FRK (fyn-related kinase) is a protein-coding gene. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is LCK.

UniProtKB/Swiss-Prot: FRK_HUMAN, P42685
Function: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates
PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination
and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor

Gene Wiki entry for FRK (Fyn-related kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRK gene promoter:
         HFH-1   YY1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRK promoter sequence
   Search Chromatin IP Primers for FRK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21-q22.3   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q21-q22.3

FRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M116308:  view genomic region     (about GC identifiers)

Start:
116,252,312 bp from pter      End:
116,381,921 bp from pter
Size:
129,610 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FRK_HUMAN, P42685 (See protein sequence)
Recommended Name: Tyrosine-protein kinase FRK  
Size: 505 amino acids; 58254 Da
Subunit: Interacts (via the SH3-domain) with PTEN. Interacts with RB1
Secondary accessions: Q13128 Q9NTR5

Explore the universe of human proteins at neXtProt for FRK: NX_P42685

Explore proteomics data for FRK at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FRK (P42685) (see all 10)
     KWTAPEA  RDLAARN  FLIRESE  GQFGEVW 


    See FRK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002022.1  
    ENSEMBL proteins: 
     ENSP00000476145   ENSP00000443075  

    FRK Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FRK

     
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    antibodies-online proteins for FRK (6 products) 

     
    antibodies-online peptides for FRK

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    antibodies-online antibodies for FRK (91 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: fyn-related kinase
    Src family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P42685

    ProtoNet protein and cluster: P42685

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FRK_HUMAN, P42685
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with FRK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRK_HUMAN, P42685
    Function: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates
    PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination
    and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI19345329
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with FRK           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FRK:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Frk):
     homeostasis/metabolism  tumorigenesis 

    Find genes that share phenotypes with FRK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Frktm1Liu for FRK

       genOway: Develop your customized and physiologically relevant rodent model for FRK

    miRNA
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    miRTarBase miRNAs that target FRK:
    hsa-mir-335-5p (MIRT018568)

    Block miRNA regulation of human, mouse, rat FRK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRK (see all 23):
    hsa-miR-30c hsa-miR-30d hsa-miR-421 hsa-miR-4275 hsa-miR-103a hsa-miR-30a hsa-miR-330-3p hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidFRK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FRK

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRK
    Addgene plasmids for FRK 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FRK_HUMAN, P42685: Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in
    the cell periphery
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane2
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS7510261
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with FRK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FRK
    Interactions:

        GeneGlobe Interaction Network for FRK

    Selected Interacting proteins for FRK (P426851, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RB1P064001, 3EBI-1383583,EBI-491274 I2D: score=4 
    PTENP604841, 3EBI-1383583,EBI-696162 I2D: score=2 
    ABI1Q8IZP02, 3MINT-7908059 I2D: score=1 
    RAC1P630002, 3MINT-4507979 I2D: score=1 
    DTX4Q9Y2E63I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS7696183
    GO:0008285negative regulation of cell proliferation TAS7664264
    GO:0018108peptidyl-tyrosine phosphorylation TAS7510261
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with FRK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FRK

    2 HMDB Compounds for FRK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for FRK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 59.8 12 15611931 (3), 8760296 (1), 19652529 (1), 20157399 (1) (see all 7)



    Find genes that share compounds with FRK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FRK gene: 
    NM_002031.2  

    Unigene Cluster for FRK:

    Fyn-related kinase
    Hs.89426  [show with all ESTs]
    Unigene Representative Sequence: NM_002031
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000606080 ENST00000538210
    miRNA
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    Block miRNA regulation of human, mouse, rat FRK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FRK (see all 23):
    hsa-miR-30c hsa-miR-30d hsa-miR-421 hsa-miR-4275 hsa-miR-103a hsa-miR-30a hsa-miR-330-3p hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidFRK 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat FRK

    Additional mRNA sequence: 

    AK302264.1 AK313314.1 BC012916.1 U00803.1 U22322.1 

    4 DOTS entries:

    DT.405693  DT.100748389  DT.100017306  DT.121389756 

    14 AceView cDNA sequences:

    NM_002031 U00803 BC012916 BX279578 BX494753 AW167319 BM787693 BG403053 
    BM833058 BU561067 U22322 BG290970 BQ310745 BE932988 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FRK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTATGAAA
    FRK Expression
    About this image


    FRK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    FRK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89426

    UniProtKB/Swiss-Prot: FRK_HUMAN, P42685
    Tissue specificity: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver,
    kidney, breast and colon

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FRK gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frk1 , 5 fyn-related kinase1, 5 87.04(n)1
    89.68(a)1
      10 (18.85 cM)5
    143021  NM_010237.31  NP_034367.21 
     344834005 
    chicken
    (Gallus gallus)
    Aves FRK1 fyn-related kinase 71.31(n)
    71.71(a)
      421747  XM_419779.4  XP_419779.3 
    lizard
    (Anolis carolinensis)
    Reptilia FRK6
    fyn-related kinase
    67(a)
    1 ↔ 1
    1(186458501-186510339)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia frk1 fyn-related kinase 66.6(n)
    63.45(a)
      100488362  XM_002938303.2  XP_002938349.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5675491 tyrosine-protein kinase FRK-like 63.44(n)
    65.64(a)
      567549  XM_690845.6  XP_695937.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Src64B3
    Src42A1
    ring canal formation protein tyrosine
    kinase3
    Src oncogene at 42A1
    48(a)3
    59.36(n)1
    63.6(a)1
      64B123
    355241  NM_057501.41  NP_476849.11 
    worm
    (Caenorhabditis elegans)
    Secernentea src-13
    src-21
    Expression: vulva, anus, mu_bod,
    pharyngeal muscle, more3
    src-21
    44(a)
    (best of 20)3
    58.78(n)1
    56.31(a)1
      I(1567610-1580076)3
    1732961  NM_061101.41  NP_493502.11 


    ENSEMBL Gene Tree for FRK (if available)
    TreeFam Gene Tree for FRK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FRK gene
    LCK2  BLK2  LYN2  FGR2  PTK62  YES12  HCK2  ABL12  
    SRC2  FYN2  ABL22  SRMS2  
    Selected SIMAP similar genes for FRK using alignment to 2 protein entries:     FRK_HUMAN (see all proteins) (see all similar genes):
    FYN    HCK    SRC    LYN    BLK    YES1
    ABL1    FGR    PTK6    TNK2    TXK    tec
    BCR/ABL fusion    FES    ABL2    BTK kinase deficient isoform 6    EPHA4    EPHB4

    Find genes that share paralogs with FRK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FRK (see all 2109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs575292121,2
    C--113847982(+) TGTGT-/GT/GT 
    GTGTGTGT
    ACACA
    1 -- int11NA 2
    rs1388235591,2
    C--116262263(+) AATGCC/TCATCA 1 -- ds50010--------
    rs1493407421,2
    --116262270(+) ATCAAC/TGATAG 1 -- ds50010--------
    rs1899370621,2
    C--116262325(+) GCAGCA/CATAAA 1 -- ds50010--------
    rs4767011,2
    C--116262388(-) ttgttG/Aagaat 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs18655111,2
    C--116262469(+) TATGGA/GCACAA 1 -- ds50010--------
    rs58793561,2
    C--116262473(+) GACAC-/AAGGAGGG 1 -- ds50010--------
    rs18655121,2
    C--116262480(+) GGAGGA/GGAACA 1 -- ds50010--------
    rs1441477241,2
    C--116262558(+) GTAGAC/TGACGG 1 -- ds50010--------
    rs21051711,2
    C,F,O,A,H--116262857(-) CAAAAC/TGGATG 1 -- ut31 ese314Minor allele frequency- T:0.15NA NS EA WA CSA 802

    HapMap Linkage Disequilibrium report for FRK (116252312 - 116381921 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FRK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1229647CNV Deletion17803354
    esv2732603CNV Deletion23290073
    esv272013CNV Insertion20981092
    esv2528433CNV Insertion19546169
    esv273944CNV Insertion20981092
    esv1334759CNV Insertion17803354
    nsv886547CNV Loss21882294
    nsv523972CNV Gain19592680

    Human Gene Mutation Database (HGMD): FRK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FRK
    DNA2.0 Custom Variant and Variant Library Synthesis for FRK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606573    OMIM disorders: --


    Find genes that share disorders with FRK           About GenesLikeMe

    1 Novoseek inferred disease relationship for FRK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 19652529 (2)

    Genetic Association Database (GAD): FRK
    Human Genome Epidemiology (HuGE) Navigator: FRK (5 documents)

    Export disorders for FRK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FRK gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with FRK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase- encoding gene. (PubMed id 7510261)1, 2, 3, 9 Lee J.... Scadden D.T. (Gene 1994)
    2. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. (PubMed id 19345329)1, 2 Yim E.-K.... Lin S.-Y. (Cancer Cell 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. (PubMed id 7664264)1, 2 Craven R.J.... Liu E.T. (Cancer Res. 1995)
    7. Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. (PubMed id 7696183)1, 2 Cance W.G.... Liu E.T. (Cell Growth Differ. 1994)
    8. Novel protein kinases expressed in human breast cancer. (PubMed id 8099900)1, 2 Cance W.G.... Liu E.T. (Int. J. Cancer 1993)
    9. RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. (PubMed id 19652529)2, 9 Brauer P.M. and Tyner A.L. (Cell Cycle 2009)
    10. Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. (PubMed id 12725532)1, 9 Serfas M.S. and Tyner A.L. (Oncol. Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2444 HGNC: 3955 AceView: FRK Ensembl:ENSG00000111816 euGenes: HUgn2444
    ECgene: FRK H-InvDB: FRK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FRK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FRK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FRK gene:
    Search GeneIP for patents involving FRK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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