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Aliases for FRK Gene

Aliases for FRK Gene

  • Fyn Related Src Family Tyrosine Kinase 2 3
  • Fyn-Related Src Family Tyrosine Kinase 2 3 5
  • Nuclear Tyrosine Protein Kinase RAK 3 4
  • PTK5 Protein Tyrosine Kinase 5 2 3
  • Protein-Tyrosine Kinase 5 3 4
  • Fyn-Related Kinase 2 3
  • EC 2.7.10.2 4 63
  • PTK5 3 4
  • RAK 3 4
  • FYN-Related Kinase 4
  • EC 2.7.10 63
  • GTK 3

External Ids for FRK Gene

Previous HGNC Symbols for FRK Gene

  • PTK5

Previous GeneCards Identifiers for FRK Gene

  • GC06M116098
  • GC06M116285
  • GC06M116308
  • GC06M116369
  • GC06M113842

Summaries for FRK Gene

Entrez Gene Summary for FRK Gene

  • The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for FRK Gene

FRK (Fyn Related Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FRK include Reticulate Acropigmentation Of Kitamura and Dowling-Degos Disease. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for FRK Gene

  • Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on Tyr-336, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Gene Wiki entry for FRK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRK Gene

Genomics for FRK Gene

Regulatory Elements for FRK Gene

Enhancers for FRK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FRK on UCSC Golden Path with GeneCards custom track

Promoters for FRK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FRK on UCSC Golden Path with GeneCards custom track

Genomic Location for FRK Gene

Chromosome:
6
Start:
115,931,149 bp from pter
End:
116,100,728 bp from pter
Size:
169,580 bases
Orientation:
Minus strand

Genomic View for FRK Gene

Genes around FRK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRK Gene

Proteins for FRK Gene

  • Protein details for FRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42685-FRK_HUMAN
    Recommended name:
    Tyrosine-protein kinase FRK
    Protein Accession:
    P42685
    Secondary Accessions:
    • B4DY49
    • Q13128
    • Q9NTR5

    Protein attributes for FRK Gene

    Size:
    505 amino acids
    Molecular mass:
    58254 Da
    Quaternary structure:
    • Interacts (via the SH3-domain) with PTEN. Interacts with RB1.

    Alternative splice isoforms for FRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRK Gene

Proteomics data for FRK Gene at MOPED

Selected DME Specific Peptides for FRK Gene

Post-translational modifications for FRK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FRK Gene

Gene Families for FRK Gene

Suggested Antigen Peptide Sequences for FRK Gene

Graphical View of Domain Structure for InterPro Entry

P42685

UniProtKB/Swiss-Prot:

FRK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FRK: view

Function for FRK Gene

Molecular function for FRK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on Tyr-336, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Enzyme Numbers (IUBMB) for FRK Gene

Gene Ontology (GO) - Molecular Function for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with FRK: view
genes like me logo Genes that share phenotypes with FRK: view

Animal Models for FRK Gene

MGI Knock Outs for FRK:

Animal Model Products

  • Taconic Biosciences Mouse Models for FRK

miRNA for FRK Gene

miRTarBase miRNAs that target FRK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRK Gene

Localization for FRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRK Gene

Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRK Gene COMPARTMENTS Subcellular localization image for FRK gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
plasma membrane 3
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FRK: view

Pathways & Interactions for FRK Gene

SuperPathways for FRK Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12837246
GO:0030154 cell differentiation IEA,IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with FRK: view

No data available for Pathways by source and SIGNOR curated interactions for FRK Gene

Drugs & Compounds for FRK Gene

(4) Drugs for FRK Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma inhibitor, Target Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Stivarga Approved February 2013/ Approved September 2012 Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for FRK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with FRK: view

Transcripts for FRK Gene

mRNA/cDNA for FRK Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRK Gene

Fyn-related kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRK Gene

No ASD Table

Relevant External Links for FRK Gene

GeneLoc Exon Structure for
FRK
ECgene alternative splicing isoforms for
FRK

Expression for FRK Gene

mRNA expression in normal human tissues for FRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRK Gene

This gene is overexpressed in Artery - Tibial (x4.2) and Artery - Coronary (x4.0).

Protein differential expression in normal tissues from HIPED for FRK Gene

This gene is overexpressed in Urine (31.9), Monocytes (23.7), and Lung (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FRK Gene



SOURCE GeneReport for Unigene cluster for FRK Gene Hs.89426

mRNA Expression by UniProt/SwissProt for FRK Gene

P42685-FRK_HUMAN
Tissue specificity: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
genes like me logo Genes that share expression patterns with FRK: view

Protein tissue co-expression partners for FRK Gene

Primer Products

Orthologs for FRK Gene

This gene was present in the common ancestor of animals.

Orthologs for FRK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FRK 35
  • 87.63 (n)
  • 88.29 (a)
FRK 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRK 35
  • 82.59 (n)
  • 81.85 (a)
FRK 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Frk 35
  • 87.04 (n)
  • 89.68 (a)
Frk 16
Frk 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FRK 35
  • 99.8 (n)
  • 99.41 (a)
FRK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Frk 35
  • 85.38 (n)
  • 88.69 (a)
oppossum
(Monodelphis domestica)
Mammalia FRK 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FRK 35
  • 71.31 (n)
  • 71.71 (a)
FRK 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRK 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frk 35
  • 66.6 (n)
  • 63.45 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC567549 35
  • 63.44 (n)
  • 65.64 (a)
fynrk 36
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9440 35
fruit fly
(Drosophila melanogaster)
Insecta Src64B 37
  • 48 (a)
Src42A 35
  • 59.36 (n)
  • 63.6 (a)
Src42A 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006270 35
  • 59.87 (n)
  • 65.02 (a)
worm
(Caenorhabditis elegans)
Secernentea C24G6.2a 37
  • 36 (a)
C24G6.2b 37
  • 36 (a)
C25A8.5 37
  • 33 (a)
C35E7.10a 37
  • 33 (a)
C55C3.4 37
  • 33 (a)
F23C8.7 37
  • 32 (a)
F57B9.8 37
  • 31 (a)
F59A3.8 37
  • 32 (a)
kin-24 37
  • 26 (a)
kin-26 37
  • 28 (a)
R11E3.1 37
  • 32 (a)
R151.4 37
  • 38 (a)
src-1 37
  • 44 (a)
T14E8.1a 37
  • 38 (a)
T14E8.1b 37
  • 38 (a)
T21G5.1 37
  • 36 (a)
T25B9.4 37
  • 28 (a)
W01B6.5 37
  • 29 (a)
Y69E1A.3 37
  • 33 (a)
ZK593.9 37
  • 26 (a)
src-2 35
  • 58.78 (n)
  • 56.31 (a)
src-2 36
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14575 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3054 36
  • 49 (a)
OneToOne
Species with no ortholog for FRK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRK Gene

ENSEMBL:
Gene Tree for FRK (if available)
TreeFam:
Gene Tree for FRK (if available)

Paralogs for FRK Gene

Paralogs for FRK Gene

genes like me logo Genes that share paralogs with FRK: view

Variants for FRK Gene

Sequence variations from dbSNP and Humsavar for FRK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3756772 - 116,003,979(-) CAATC(A/G)GAAGA reference, missense
rs34704018 - 116,060,014(+) AGGAA(C/T)ATAGC intron-variant, reference, missense
rs34064900 - 116,003,945(+) TTTCT(A/G)AATAT reference, missense
rs1009279 -- 116,001,759(+) ctttg(C/T)tttac intron-variant
rs1067048 -- 115,961,564(+) tcctc(A/G)agaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRK Gene

Variant ID Type Subtype PubMed ID
nsv886547 CNV Loss 21882294
nsv523972 CNV Gain 19592680
esv2732603 CNV Deletion 23290073
esv1229647 CNV Deletion 17803354
esv272013 CNV Insertion 20981092
esv273944 CNV Insertion 20981092
esv2528433 CNV Insertion 19546169
esv1334759 CNV Insertion 17803354

Variation tolerance for FRK Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRK Gene

Human Gene Mutation Database (HGMD)
FRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRK Gene

Disorders for FRK Gene

MalaCards: The human disease database

(4) MalaCards diseases for FRK Gene - From: DISEASES

Disorder Aliases PubMed IDs
reticulate acropigmentation of kitamura
  • rapk
dowling-degos disease
  • reticulate acropigmentation of kitamura
dyschromatosis symmetrica hereditaria
  • reticulate acropigmentation of dohi
pigmentation disease
  • pigmentation disorders
- elite association - COSMIC cancer census association via MalaCards
Search FRK in MalaCards View complete list of genes associated with diseases

Relevant External Links for FRK

Genetic Association Database (GAD)
FRK
Human Genome Epidemiology (HuGE) Navigator
FRK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRK
genes like me logo Genes that share disorders with FRK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FRK Gene

Publications for FRK Gene

  1. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase- encoding gene. (PMID: 7510261) Lee J. … Scadden D.T. (Gene 1994) 2 3 4 23 67
  2. Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. (PMID: 12725532) Serfas M.S. … Tyner A.L. (Oncol. Res. 2003) 3 23
  3. FRK inhibits migration and invasion of human glioma cells by promoting N-cadherin/I^-catenin complex formation. (PMID: 24969324) Shi Q. … Yu R. (J. Mol. Neurosci. 2015) 3
  4. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  5. Antagomir-1290 suppresses CD133a8_ cells in non-small cell lung cancer by targeting fyn-related Src family tyrosine kinase. (PMID: 25783528) Sun B. … Zuo P. (Tumour Biol. 2015) 3

Products for FRK Gene

Sources for FRK Gene

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