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Aliases for FRG2C Gene

Aliases for FRG2C Gene

  • FSHD Region Gene 2 Family Member C 2 3 5
  • FSHD Region Gene 2 Protein Family Member C 3 4
  • FSHD Region Gene 2 Family, Member C 2 3
  • HSA3-FRG2 3 4

External Ids for FRG2C Gene

Previous GeneCards Identifiers for FRG2C Gene

  • GC03P075799
  • GC00M8M0087
  • GC03P075714
  • GC03P075715
  • GC03P075716
  • GC03P075724
  • GC03P075728
  • GC03P075664

Summaries for FRG2C Gene

GeneCards Summary for FRG2C Gene

FRG2C (FSHD Region Gene 2 Family Member C) is a Protein Coding gene. An important paralog of this gene is FRG2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRG2C Gene

Genomics for FRG2C Gene

Genomic Location for FRG2C Gene

Chromosome:
3
Start:
75,646,783 bp from pter
End:
75,667,220 bp from pter
Size:
20,438 bases
Orientation:
Plus strand

Genomic View for FRG2C Gene

Genes around FRG2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRG2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRG2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRG2C Gene

No data available for Regulatory Elements for FRG2C Gene

Proteins for FRG2C Gene

  • Protein details for FRG2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGY1-FRG2C_HUMAN
    Recommended name:
    Protein FRG2-like-2
    Protein Accession:
    A6NGY1

    Protein attributes for FRG2C Gene

    Size:
    282 amino acids
    Molecular mass:
    30798 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FRG2C Gene

Proteomics data for FRG2C Gene at MOPED

Post-translational modifications for FRG2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRG2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRG2C Gene

Domains & Families for FRG2C Gene

Protein Domains for FRG2C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRG2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGY1

UniProtKB/Swiss-Prot:

FRG2C_HUMAN :
  • Belongs to the FRG2 family.
Family:
  • Belongs to the FRG2 family.
genes like me logo Genes that share domains with FRG2C: view

No data available for Gene Families for FRG2C Gene

Function for FRG2C Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FRG2C Gene

Localization for FRG2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRG2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRG2C Gene COMPARTMENTS Subcellular localization image for FRG2C gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for FRG2C Gene

Pathways & Interactions for FRG2C Gene

SuperPathways for FRG2C Gene

No Data Available

Interacting Proteins for FRG2C Gene

Gene Ontology (GO) - Biological Process for FRG2C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FRG2C Gene

Drugs & Compounds for FRG2C Gene

No Compound Related Data Available

Transcripts for FRG2C Gene

mRNA/cDNA for FRG2C Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRG2C Gene

FSHD region gene 2 family, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRG2C Gene

No ASD Table

Relevant External Links for FRG2C Gene

GeneLoc Exon Structure for
FRG2C
ECgene alternative splicing isoforms for
FRG2C

Expression for FRG2C Gene

mRNA expression in normal human tissues for FRG2C Gene

mRNA differential expression in normal tissues according to GTEx for FRG2C Gene

This gene is overexpressed in Testis (x19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FRG2C Gene



SOURCE GeneReport for Unigene cluster for FRG2C Gene Hs.274541

genes like me logo Genes that share expression patterns with FRG2C: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FRG2C Gene

Orthologs for FRG2C Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRG2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia AA415398 36
  • 33 (a)
OneToMany
Species with no ortholog for FRG2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRG2C Gene

ENSEMBL:
Gene Tree for FRG2C (if available)
TreeFam:
Gene Tree for FRG2C (if available)

Paralogs for FRG2C Gene

Paralogs for FRG2C Gene

(2) SIMAP similar genes for FRG2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FRG2C: view

Variants for FRG2C Gene

Sequence variations from dbSNP and Humsavar for FRG2C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13073018 - 75,664,413(+) TCCAC(C/T)GTTCC reference, missense
rs13096122 - 75,665,820(+) TGACA(A/C)TGCTC reference, missense
rs181282 -- 75,667,351(-) TCCAA(C/T)TTATA downstream-variant-500B
rs181283 -- 75,662,335(-) aaaat(A/C)caaaa intron-variant, upstream-variant-2KB
rs2165003 -- 75,660,451(-) tccca(C/T)tactt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRG2C Gene

Variant ID Type Subtype PubMed ID
esv2422315 CNV Deletion 17116639
esv614 CNV CNV 17122850
nsv529016 CNV Gain 19592680
esv26581 CNV Gain+Loss 19812545
dgv181e55 CNV Loss 17911159
dgv1469e1 CNV Complex 17122850
dgv1471e1 CNV Complex 17122850
nsv834737 CNV Gain+Loss 17160897
nsv876983 CNV Gain 21882294
nsv876984 CNV Gain 21882294
dgv1472e1 CNV Complex 17122850
dgv1473e1 CNV Complex 17122850
essv18298 CNV CNV 17122850
nsv428418 CNV Loss 18775914
nsv822137 CNV Gain 20364138
nsv876985 CNV Gain 21882294
nsv10283 CNV Gain+Loss 18304495
nsv819834 CNV Insertion 19587683
nsv876986 CNV Gain 21882294
nsv876987 CNV Gain 21882294
dgv1474e1 CNV Complex 17122850
nsv821408 CNV Duplication 20802225
nsv822138 CNV Gain 20364138

Relevant External Links for FRG2C Gene

HapMap Linkage Disequilibrium report
FRG2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FRG2C Gene

Disorders for FRG2C Gene

Relevant External Links for FRG2C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRG2C

No disorders were found for FRG2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRG2C Gene

Publications for FRG2C Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 67
  2. FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients. (PMID: 15520407) Rijkers T. … van der Maarel S.M. (J. Med. Genet. 2004) 3
  3. Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. (PMID: 11245978) Beckers M.-C. … Belayew A. (Gene 2001) 3

Products for FRG2C Gene

Sources for FRG2C Gene

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