Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FRG2B Gene

Aliases for FRG2B Gene

  • FSHD Region Gene 2 Family, Member B 2 3
  • FSHD Region Gene 2 Protein Family Member B 3 4
  • HSA10-FRG2 3 4
  • Protein FRG2-Like-1 3

External Ids for FRG2B Gene

Summaries for FRG2B Gene

GeneCards Summary for FRG2B Gene

FRG2B (FSHD Region Gene 2 Family, Member B) is a Protein Coding gene. An important paralog of this gene is FRG2C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRG2B Gene

Genomics for FRG2B Gene

Genomic Location for FRG2B Gene

Start:
133,623,895 bp from pter
End:
133,626,795 bp from pter
Size:
2,901 bases
Orientation:
Minus strand

Genomic View for FRG2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRG2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRG2B Gene

Regulatory Elements for FRG2B Gene

Proteins for FRG2B Gene

  • Protein details for FRG2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QU4-FRG2B_HUMAN
    Recommended name:
    Protein FRG2-like-1
    Protein Accession:
    Q96QU4
    Secondary Accessions:
    • Q5VSQ1

    Protein attributes for FRG2B Gene

    Size:
    278 amino acids
    Molecular mass:
    30564 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FRG2B Gene

Proteomics data for FRG2B Gene at MOPED

Post-translational modifications for FRG2B Gene

No Post-translational modifications

Other Protein References for FRG2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRG2B Gene

Domains for FRG2B Gene

Protein Domains for FRG2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRG2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QU4

UniProtKB/Swiss-Prot:

FRG2B_HUMAN
Family:
  • Belongs to the FRG2 family.:
    • Q96QU4
genes like me logo Genes that share domains with FRG2B: view

No data available for Gene Families for FRG2B Gene

Function for FRG2B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FRG2B Gene

Localization for FRG2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRG2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRG2B Gene COMPARTMENTS Subcellular localization image for FRG2B gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FRG2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FRG2B: view

Pathways for FRG2B Gene

SuperPathways for FRG2B Gene

No Data Available

Interacting Proteins for FRG2B Gene

Gene Ontology (GO) - Biological Process for FRG2B Gene

None

No data available for Pathways by source for FRG2B Gene

Transcripts for FRG2B Gene

mRNA/cDNA for FRG2B Gene

(4) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FRG2B Gene

No ASD Table

Relevant External Links for FRG2B Gene

GeneLoc Exon Structure for
FRG2B
ECgene alternative splicing isoforms for
FRG2B

Expression for FRG2B Gene

mRNA expression in normal human tissues for FRG2B Gene

mRNA differential expression in normal tissues according to GTEx for FRG2B Gene

This gene is overexpressed in Brain - Cerebellum (10.7), Brain - Cerebellar Hemisphere (8.7), Brain - Cortex (7.5), and Brain - Frontal Cortex (BA9) (6.2).

SOURCE GeneReport for Unigene cluster for FRG2B Gene Hs.690471

genes like me logo Genes that share expressions with FRG2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for FRG2B Gene

Orthologs for FRG2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRG2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
LOC735441 35
  • 98.44 (n)
  • 97.12 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 42 (a)
OneToMany
LOC101904879 35
  • 62.3 (n)
  • 43.85 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 46 (a)
OneToMany
LOC100855990 35
  • 63.9 (n)
  • 48.96 (a)
mouse
(Mus musculus)
Mammalia AA415398 36
  • 35 (a)
OneToMany
Gm6234 35
  • 70.46 (n)
  • 54.43 (a)
rat
(Rattus norvegicus)
Mammalia Frg2 35
  • 58.68 (n)
  • 43.11 (a)
Species with no ortholog for FRG2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRG2B Gene

ENSEMBL:
Gene Tree for FRG2B (if available)
TreeFam:
Gene Tree for FRG2B (if available)

Paralogs for FRG2B Gene

Paralogs for FRG2B Gene

Selected SIMAP similar genes for FRG2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FRG2B: view

Variants for FRG2B Gene

Sequence variations from dbSNP and Humsavar for FRG2B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9630046 -- 133,628,103(+) ATATC(A/G)TTATA upstream-variant-2KB
rs36080873 -- 133,627,187(-) AATTA(C/T)AATAT upstream-variant-2KB
rs61868730 -- 133,626,074(+) ACACA(C/T)AGGAG intron-variant
rs61868731 -- 133,626,137(+) TGTAC(A/G)GCCCT intron-variant
rs61868732 -- 133,626,191(+) TTGCT(G/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRG2B Gene

Variant ID Type Subtype PubMed ID
nsv428243 CNV Gain 18775914
esv28562 CNV Gain+Loss 19812545
nsv8752 CNV Gain+Loss 18304495
dgv904n71 CNV Gain 21882294
dgv905n71 CNV Gain 21882294
dgv909n71 CNV Loss 21882294
nsv896428 CNV Gain 21882294
nsv442214 CNV CNV 18776908
nsv896430 CNV Loss 21882294
nsv896431 CNV Gain 21882294
nsv896432 CNV Loss 21882294
nsv896433 CNV Gain 21882294
dgv4n31 CNV Duplication 19718026

Relevant External Links for FRG2B Gene

HapMap Linkage Disequilibrium report
FRG2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRG2B Gene

Disorders for FRG2B Gene

(1) University of Copenhagen DISEASES for FRG2B Gene

genes like me logo Genes that share disorders with FRG2B: view

No data available for UniProtKB/Swiss-Prot for FRG2B Gene

Publications for FRG2B Gene

  1. FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients. (PMID: 15520407) Rijkers T. … van der Maarel S.M. (J. Med. Genet. 2004) 2 3 4
  2. Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. (PMID: 11829491) van Geel M. … Hewitt J.E. (Genomics 2002) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for FRG2B Gene

Sources for FRG2B Gene

Back to Top

Content