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Aliases for FRG2B Gene

Aliases for FRG2B Gene

  • FSHD Region Gene 2 Family Member B 2 3 5
  • FSHD Region Gene 2 Protein Family Member B 3 4
  • FSHD Region Gene 2 Family, Member B 2 3
  • HSA10-FRG2 3 4

External Ids for FRG2B Gene

Previous GeneCards Identifiers for FRG2B Gene

  • GC10M135288
  • GC10M135437
  • GC10M128980

Summaries for FRG2B Gene

GeneCards Summary for FRG2B Gene

FRG2B (FSHD Region Gene 2 Family Member B) is a Protein Coding gene. An important paralog of this gene is FRG2C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRG2B Gene

Genomics for FRG2B Gene

Regulatory Elements for FRG2B Gene

Genomic Location for FRG2B Gene

133,623,895 bp from pter
133,627,886 bp from pter
3,992 bases
Minus strand

Genomic View for FRG2B Gene

Genes around FRG2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRG2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRG2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRG2B Gene

Proteins for FRG2B Gene

  • Protein details for FRG2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FRG2-like-1
    Protein Accession:
    Secondary Accessions:
    • Q5VSQ1

    Protein attributes for FRG2B Gene

    278 amino acids
    Molecular mass:
    30564 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FRG2B Gene

Proteomics data for FRG2B Gene at MOPED

Post-translational modifications for FRG2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRG2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRG2B Gene

Domains & Families for FRG2B Gene

Protein Domains for FRG2B Gene


Suggested Antigen Peptide Sequences for FRG2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FRG2 family.
  • Belongs to the FRG2 family.
genes like me logo Genes that share domains with FRG2B: view

No data available for Gene Families for FRG2B Gene

Function for FRG2B Gene

genes like me logo Genes that share phenotypes with FRG2B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FRG2B Gene

Localization for FRG2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRG2B Gene

Subcellular locations from

Jensen Localization Image for FRG2B Gene COMPARTMENTS Subcellular localization image for FRG2B gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for FRG2B Gene

Pathways & Interactions for FRG2B Gene

SuperPathways for FRG2B Gene

No Data Available

Interacting Proteins for FRG2B Gene

Gene Ontology (GO) - Biological Process for FRG2B Gene


No data available for Pathways by source and SIGNOR curated interactions for FRG2B Gene

Drugs & Compounds for FRG2B Gene

No Compound Related Data Available

Transcripts for FRG2B Gene

mRNA/cDNA for FRG2B Gene

(4) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FRG2B Gene

No ASD Table

Relevant External Links for FRG2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRG2B Gene

mRNA expression in normal human tissues for FRG2B Gene

mRNA differential expression in normal tissues according to GTEx for FRG2B Gene

This gene is overexpressed in Brain - Cerebellum (x10.7), Brain - Cerebellar Hemisphere (x8.7), Brain - Cortex (x7.5), and Brain - Frontal Cortex (BA9) (x6.2).

SOURCE GeneReport for Unigene cluster for FRG2B Gene Hs.690471

genes like me logo Genes that share expression patterns with FRG2B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FRG2B Gene

Orthologs for FRG2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRG2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101904879 35
  • 62.3 (n)
  • 43.85 (a)
-- 36
  • 42 (a)
(Canis familiaris)
Mammalia LOC100855990 35
  • 63.9 (n)
  • 48.96 (a)
-- 36
  • 46 (a)
(Mus musculus)
Mammalia Gm6234 35
  • 70.46 (n)
  • 54.43 (a)
Gm9328 16
AA415398 36
  • 35 (a)
(Pan troglodytes)
Mammalia LOC735441 35
  • 98.44 (n)
  • 97.12 (a)
-- 36
  • 96 (a)
-- 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Frg2 35
  • 58.68 (n)
  • 43.11 (a)
Species with no ortholog for FRG2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRG2B Gene

Gene Tree for FRG2B (if available)
Gene Tree for FRG2B (if available)

Paralogs for FRG2B Gene

Paralogs for FRG2B Gene

(2) SIMAP similar genes for FRG2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FRG2B: view

Variants for FRG2B Gene

Sequence variations from dbSNP and Humsavar for FRG2B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2078057 -- 133,629,600(-) CCAAA(C/T)TAAAA upstream-variant-2KB
rs2078058 -- 133,629,576(-) ACCCA(C/T)TTTTA upstream-variant-2KB
rs4644609 -- 133,629,522(+) TCAAA(A/C/T)AAAAA upstream-variant-2KB
rs9629945 -- 133,629,724(+) CCAGG(C/T)TGATG upstream-variant-2KB
rs9630046 -- 133,628,103(+) ATATC(A/G)TTATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FRG2B Gene

Variant ID Type Subtype PubMed ID
nsv428243 CNV Gain 18775914
esv28562 CNV Gain+Loss 19812545
nsv8752 CNV Gain+Loss 18304495
dgv904n71 CNV Gain 21882294
dgv905n71 CNV Gain 21882294
dgv909n71 CNV Loss 21882294
nsv896428 CNV Gain 21882294
nsv442214 CNV CNV 18776908
nsv896430 CNV Loss 21882294
nsv896431 CNV Gain 21882294
nsv896432 CNV Loss 21882294
nsv896433 CNV Gain 21882294
dgv4n31 CNV Duplication 19718026

Variation tolerance for FRG2B Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRG2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRG2B Gene

Disorders for FRG2B Gene

Relevant External Links for FRG2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FRG2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRG2B Gene

Publications for FRG2B Gene

  1. FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients. (PMID: 15520407) Rijkers T. … van der Maarel S.M. (J. Med. Genet. 2004) 2 3 4 67
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3
  3. Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. (PMID: 11829491) van Geel M. … Hewitt J.E. (Genomics 2002) 3

Products for FRG2B Gene

Sources for FRG2B Gene

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