FRG2B Gene
protein-coding GIFtS: 36
GCID: GC10M135437
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FSHD region gene 2 family, member B
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Aliases
for FRG2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FSHD Region Gene 2 Family, Member B1 2 | | HSA10-FRG22 3 | | FSHD Region Gene 2 Protein Family Member B2 3 | | Protein FRG2-Like-12 |
Export aliases for FRG2B gene to outside databasesPrevious GC identifers: GC10M135288 GC10M128980 |
Summaries
for FRG2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FRG2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008818.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FRG2B gene promoter:
TBP POU2F1 AML1a POU2F1a SEF-1 (1) FOXL1 C/EBPalpha GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FRG2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRG2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3FRG2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M135437: view genomic region
(about GC identifiers)
Start:
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135,437,399 bp from pter |
End:
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135,440,299 bp from pter |
Size:
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2,901 bases |
Orientation:
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minus strand |
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Proteins
for FRG2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FRG2B_HUMAN, Q96QU4 (See
protein sequence)Recommended Name: Protein FRG2-like-1 Size: 278 amino acids; 30564 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5VSQ1Explore the universe of human proteins at neXtProt for FRG2B: NX_Q96QU4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96QU4
FRG2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001074467.1
ENSEMBL proteins: ENSP00000408343 ENSP00000401310
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
FRG2B for ontologies About GeneDecksing
FRG2B Antibody Products:
Assay Products for FRG2B: |
Protein
Domains /
Families
for FRG2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FRG2B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96QU4ProtoNet protein and cluster: Q96QU4 UniProtKB/Swiss-Prot: FRG2B_HUMAN, Q96QU4Similarity: Belongs to the FRG2 family |
Function
for FRG2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRG2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRG2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FRG2B (NM_001080998) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FRG2B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FRG2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRG2B |
|
Pathways & Interactions
for FRG2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FRG2B
|
Drugs & Compounds
for FRG2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FRG2B
Search CenterWatch for drugs/clinical trials and news about FRG2B
|
Transcripts
for FRG2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FRG2B gene: NM_001080998.1 Unigene Cluster for FRG2B: FSHD region gene 2 family, member B Hs.690471 Unigene Representative Sequence: AY7444663 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000443774 ENST00000495459 ENST00000425520(uc010qvg.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRG2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRG2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FRG2B (NM_001080998) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FRG2B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FRG2B |
Additional cDNA sequence: AY744466.1 1 DOTS entry: DT.121293300 1 AceView cDNA sequence: AI124612
GeneLoc Exon Structure
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Expression
for FRG2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FRG2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACCCAGG
About this image
See FRG2B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.690471
SABiosciences Custom PCR Arrays for FRG2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRG2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRG2B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRG2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRG2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRG2B |
Orthologs
for FRG2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for FRG2B (if available)
TreeFam Gene Tree for FRG2B (if available) |
Paralogs
for FRG2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FRG2B gene
- FRG21 2 LOC100288255 LOC2852992 ENSG000001488282 FRG2C2
2 SIMAP similar genes for FRG2B using alignment to 1 protein entry: FRG2B_HUMAN:FRG2 FRG2C
FRG2B for paralogs About GeneDecksing
|
Genomic Variants
for FRG2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FRG2B (135437399 - 135440299 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for FRG2B
7 CNVs: 71203 75474 85570 65825 85572 37652 30527 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRG2B |
|
Disorders
/ Diseases
for FRG2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FRG2B for disorders About GeneDecksing
2  diseases for FRG2B: About MalaCardsfacioscapulohumeral muscular dystrophy muscular dystrophy
1 disease from the University of Copenhagen DISEASES database for FRG2B:Facioscapulohumeral muscular dystrophy Export disorders for FRG2B gene to outside databases
|
Publications
for FRG2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FRG2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FRG2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients. (PubMed id 15520407)1, 2, 3 Rijkers T....van der Maarel S.M. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. (PubMed id 11829491)1, 2 van Geel M.... Hewitt J.E. (2002)
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External Searches for FRG2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FRG2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FRG2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FRG2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FRG2B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FRG2B gene:
Search GeneIP for patents involving FRG2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FRG2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FRG2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRG2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRG2B | | | OriGene Protein Over-expression Lysate for FRG2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FRG2B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRG2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRG2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FRG2B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for FRG2B |
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 | | | FRG2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRG2B |
|  |  |  | | | | ThermoFisher Antibodies for FRG2B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FRG2B |
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