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Aliases for FRG2 Gene

Aliases for FRG2 Gene

  • FSHD Region Gene 2 2 3
  • FSHD Region Gene 2 Protein 3 4
  • FRG2A 3 4
  • Protein FRG2 3

External Ids for FRG2 Gene

Previous GeneCards Identifiers for FRG2 Gene

  • GC10M135327
  • GC04U900480
  • GC04M191182
  • GC04M190945

Summaries for FRG2 Gene

GeneCards Summary for FRG2 Gene

FRG2 (FSHD Region Gene 2) is a Protein Coding gene. An important paralog of this gene is FRG2C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRG2 Gene

Genomics for FRG2 Gene

Regulatory Elements for FRG2 Gene

Genomic Location for FRG2 Gene

Start:
190,024,351 bp from pter
End:
190,027,257 bp from pter
Size:
2,907 bases
Orientation:
Minus strand

Genomic View for FRG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRG2 Gene

Proteins for FRG2 Gene

  • Protein details for FRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q64ET8-FRG2_HUMAN
    Recommended name:
    Protein FRG2
    Protein Accession:
    Q64ET8
    Secondary Accessions:
    • B7ZMJ1
    • E7EN36

    Protein attributes for FRG2 Gene

    Size:
    278 amino acids
    Molecular mass:
    30490 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRG2 Gene

Proteomics data for FRG2 Gene at MOPED

Post-translational modifications for FRG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRG2 Gene

Domains for FRG2 Gene

Protein Domains for FRG2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q64ET8

UniProtKB/Swiss-Prot:

FRG2_HUMAN :
  • Q64ET8
Family:
  • Belongs to the FRG2 family.
genes like me logo Genes that share domains with FRG2: view

No data available for Gene Families for FRG2 Gene

Function for FRG2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FRG2 Gene

Localization for FRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRG2 Gene COMPARTMENTS Subcellular localization image for FRG2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FRG2: view

Pathways for FRG2 Gene

SuperPathways for FRG2 Gene

No Data Available

Interacting Proteins for FRG2 Gene

Gene Ontology (GO) - Biological Process for FRG2 Gene

None

No data available for Pathways by source for FRG2 Gene

Transcripts for FRG2 Gene

mRNA/cDNA for FRG2 Gene

(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FRG2 Gene

No ASD Table

Relevant External Links for FRG2 Gene

GeneLoc Exon Structure for
FRG2
ECgene alternative splicing isoforms for
FRG2

Expression for FRG2 Gene

mRNA expression in normal human tissues for FRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRG2 Gene

This gene is overexpressed in Brain - Cerebellum (20.2) and Brain - Cerebellar Hemisphere (18.9).

SOURCE GeneReport for Unigene cluster for FRG2 Gene Hs.626907

mRNA Expression by UniProt/SwissProt for FRG2 Gene

Q64ET8-FRG2_HUMAN
Tissue specificity: Expression is undetectable in all tissues tested except for differentiating myoblasts of FSHD patients, which display low, yet distinct levels of expression, partly from FRG2, but predominantly originating from its homolog on chromosome 10.
genes like me logo Genes that share expressions with FRG2: view

No data available for Protein expression for FRG2 Gene

Orthologs for FRG2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
LOC735441 35
  • 98.08 (n)
  • 96.76 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 42 (a)
OneToMany
LOC101904879 35
  • 61.63 (n)
  • 42.45 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 45 (a)
OneToMany
LOC100855990 35
  • 59.92 (n)
  • 46.28 (a)
mouse
(Mus musculus)
Mammalia AA415398 36
  • 35 (a)
OneToMany
Gm6219 16
Gm9326 35
  • 70.04 (n)
  • 54.43 (a)
rat
(Rattus norvegicus)
Mammalia Frg2 35
  • 59.3 (n)
  • 43.02 (a)
Species with no ortholog for FRG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRG2 Gene

ENSEMBL:
Gene Tree for FRG2 (if available)
TreeFam:
Gene Tree for FRG2 (if available)

Paralogs for FRG2 Gene

Paralogs for FRG2 Gene

Selected SIMAP similar genes for FRG2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FRG2 Gene

genes like me logo Genes that share paralogs with FRG2: view

Variants for FRG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for FRG2 Gene

Variant ID Type Subtype PubMed ID
dgv5873n71 CNV Loss 21882294
nsv880818 CNV Gain 21882294
dgv5875n71 CNV Gain 21882294
nsv10641 CNV Loss 18304495
nsv880553 CNV Gain 21882294
nsv471487 CNV Duplication 19718026
nsv513204 CNV Loss 21212237
esv23426 CNV Gain+Loss 19812545
nsv482089 CNV Gain 20164927

Relevant External Links for FRG2 Gene

HapMap Linkage Disequilibrium report
FRG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FRG2 Gene

Disorders for FRG2 Gene

(1) University of Copenhagen DISEASES for FRG2 Gene

genes like me logo Genes that share disorders with FRG2: view

No data available for UniProtKB/Swiss-Prot for FRG2 Gene

Publications for FRG2 Gene

  1. FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients. (PMID: 15520407) Rijkers T. … van der Maarel S.M. (J. Med. Genet. 2004) 2 3 4 23
  2. Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. (PMID: 12176321) Gabellini D. … Tupler R. (Cell 2002) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Clinical features of facioscapulohumeral muscular dystrophy 2. (PMID: 20975055) de Greef J.C. … Tawil R. (Neurology 2010) 3
  5. Expression profiling of FSHD-1 and FSHD-2 cells during myogenic differentiation evidences common and distinctive gene dysregulation patterns. (PMID: 21695143) Cheli S. … Meneveri R. (PLoS ONE 2011) 3

Products for FRG2 Gene

Sources for FRG2 Gene

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