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Aliases for FRG1B Gene

Aliases for FRG1B Gene

  • FSHD Region Gene 1 Family, Member B 2 3
  • C20orf80 3 4
  • Chromosome 20 Open Reading Frame 80 2
  • BA348I14.2 3

External Ids for FRG1B Gene

Previous HGNC Symbols for FRG1B Gene

  • C20orf80

Previous GeneCards Identifiers for FRG1B Gene

  • GC20P028229
  • GC20P028232
  • GC20P029611
  • GC20P026509

Summaries for FRG1B Gene

GeneCards Summary for FRG1B Gene

FRG1B (FSHD Region Gene 1 Family, Member B) is a Pseudogene. An important paralog of this gene is FRG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRG1B Gene

Genomics for FRG1B Gene

Regulatory Elements for FRG1B Gene

Genomic Location for FRG1B Gene

Start:
30,377,181 bp from pter
End:
30,399,334 bp from pter
Size:
22,154 bases
Orientation:
Plus strand

Genomic View for FRG1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRG1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRG1B Gene

Proteins for FRG1B Gene

  • Protein details for FRG1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ01-FRG1B_HUMAN
    Recommended name:
    Protein FRG1B
    Protein Accession:
    Q9BZ01
    Secondary Accessions:
    • C4AME5

    Protein attributes for FRG1B Gene

    Size:
    182 amino acids
    Molecular mass:
    20762 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FRG1B Gene

Proteomics data for FRG1B Gene at MOPED

Post-translational modifications for FRG1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRG1B Gene

No data available for DME Specific Peptides for FRG1B Gene

Domains for FRG1B Gene

Protein Domains for FRG1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRG1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZ01

UniProtKB/Swiss-Prot:

FRG1B_HUMAN :
  • Q9BZ01
Family:
  • Belongs to the FRG1 family.
genes like me logo Genes that share domains with FRG1B: view

No data available for Gene Families for FRG1B Gene

Function for FRG1B Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRG1B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FRG1B Gene

Localization for FRG1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRG1B Gene COMPARTMENTS Subcellular localization image for FRG1B gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FRG1B Gene

Pathways for FRG1B Gene

SuperPathways for FRG1B Gene

No Data Available

Interacting Proteins for FRG1B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278882%0d%0a9606.ENSP00000362728%0d%0a9606.ENSP00000304370%0d%0a9606.ENSP00000227524%0d%0a
Selected Interacting proteins: ENSP00000278882 for FRG1B Gene via STRING

Gene Ontology (GO) - Biological Process for FRG1B Gene

None

No data available for Pathways by source for FRG1B Gene

Transcripts for FRG1B Gene

Unigene Clusters for FRG1B Gene

FSHD region gene 1 family, member B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRG1B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRG1B Gene

No ASD Table

Relevant External Links for FRG1B Gene

GeneLoc Exon Structure for
FRG1B
ECgene alternative splicing isoforms for
FRG1B

Expression for FRG1B Gene

mRNA expression in normal human tissues for FRG1B Gene

Protein differential expression in normal tissues for FRG1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FRG1B Gene

SOURCE GeneReport for Unigene cluster for FRG1B Gene Hs.653099

genes like me logo Genes that share expressions with FRG1B: view

Expression partners for FRG1B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FRG1B Gene

Orthologs for FRG1B Gene

This gene was present in the common ancestor of animals.

Orthologs for FRG1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FRG1 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6480 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frg-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for FRG1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FRG1B Gene

ENSEMBL:
Gene Tree for FRG1B (if available)
TreeFam:
Gene Tree for FRG1B (if available)

Paralogs for FRG1B Gene

Paralogs for FRG1B Gene

Selected SIMAP similar genes for FRG1B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FRG1B Gene

genes like me logo Genes that share paralogs with FRG1B: view

Variants for FRG1B Gene

Sequence variations from dbSNP and Humsavar for FRG1B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs507860 -- 30,382,655(+) AAAAG(A/C/G)AAAAA intron-variant
rs1061724 -- 30,377,624(+) TCCCG(C/T)GCTGA intron-variant
rs1061937 -- 30,375,369(-) AGTTT(G/T)GCGAA upstream-variant-2KB
rs1138756 -- 30,377,252(+) ACGTA(C/G)GCTGT nc-transcript-variant
rs1803594 -- 30,397,986(+) GAAGA(C/G)AGTAA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FRG1B Gene

Variant ID Type Subtype PubMed ID
dgv1324e1 CNV Complex 17122850
nsv428376 CNV Gain 18775914
nsv833950 CNV Gain 17160897
essv9486 CNV CNV 17122850
esv21823 CNV Gain+Loss 19812545
nsv821487 CNV Duplication 20802225
nsv828711 CNV Gain 20364138

Relevant External Links for FRG1B Gene

HapMap Linkage Disequilibrium report
FRG1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRG1B Gene

Disorders for FRG1B Gene

No disorders were found for FRG1B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FRG1B Gene

Publications for FRG1B Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21. (PMID: 19586940) An Q. … Strefford J.C. (Haematologica 2009) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for FRG1B Gene

Sources for FRG1B Gene

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