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FRG1 Gene

protein-coding   GIFtS: 58
GCID: GC04P190861

FSHD Region Gene 1

  See FRG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FSHD Region Gene 11 2
FSHD Region Gene 1 Protein2 3
FSG12 5
FRG1A2
Facioscapulohumeral Muscular Dystrophy Region Gene-12
Protein FRG12

External Ids:    HGNC: 39541   Entrez Gene: 24832   Ensembl: ENSG000001095367   OMIM: 6012785   UniProtKB: Q143313   

Export aliases for FRG1 gene to outside databases

Previous GC identifers: GC04P191891 GC04P191510 GC04P191446 GC04P191557 GC04P191237 GC04P191098 GC04P186602


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FRG1 Gene:
This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in
facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on
multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies
demonstrate the encoded protein is localized to the nucleolus. (provided by RefSeq, Jul 2008)

GeneCards Summary for FRG1 Gene:
FRG1 (FSHD region gene 1) is a protein-coding gene. Diseases associated with FRG1 include fascioscapulohumeral muscular dystrophy 2, digenic, and suppurative lymphadenitis. An important paralog of this gene is ENSG00000220023.

UniProtKB/Swiss-Prot: FRG1_HUMAN, Q14331
Function: May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits. May be
involved in pre-mRNA splicing

Gene Wiki entry for FRG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NT_187650.1  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FRG1 gene promoter:
         Max1   GCNF-1   GCNF   GCNF-2   MRF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFRG1 promoter sequence
   Search Chromatin IP Primers for FRG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35

FRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRG1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P190861:  view genomic region     (about GC identifiers)

Start:
190,861,943 bp from pter      End:
190,884,359 bp from pter
Size:
22,417 bases      Orientation:
plus strand

1 alternative location:
Chr4+,NW_003571034 33,749-56,134     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FRG1_HUMAN, Q14331 (See protein sequence)
Recommended Name: Protein FRG1  
Size: 258 amino acids; 29172 Da
Subunit: Identified in the spliceosome C complex
Secondary accessions: A8K775

Explore the universe of human proteins at neXtProt for FRG1: NX_Q14331

Explore proteomics data for FRG1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys115
  • Modification sites at PhosphoSitePlus

  • See FRG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004468.1  
    ENSEMBL proteins: 
     ENSP00000226798   ENSP00000435067   ENSP00000436535   ENSP00000435943   ENSP00000462603  

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    antibodies-online proteins for FRG1 (6 products) 

     
    antibodies-online peptides for FRG1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010414 FRG1
     IPR008999 Actin_cross-linking

    Graphical View of Domain Structure for InterPro Entry Q14331

    ProtoNet protein and cluster: Q14331

    1 Blocks protein domain: IPB002345 Lipocalin signature

    UniProtKB/Swiss-Prot: FRG1_HUMAN, Q14331
    Similarity: Belongs to the FRG1 family


    Find genes that share domains with FRG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRG1_HUMAN, Q14331
    Function: May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits. May be
    involved in pre-mRNA splicing

         Genatlas biochemistry entry for FRG1:
    FSHMD1A (FSHD) region gene 1,expressed in placenta,lymphocytes,brain,muscle,putative transport protein,with
    multiple copies resulting from ancestral duplication,dispersed throughout the genome

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0030674protein binding, bridging ----
    GO:0044822poly(A) RNA binding IDA--
    GO:0051015actin filament binding ----
         
    Find genes that share ontologies with FRG1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FRG1

    miRNA
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    miRTarBase miRNAs that target FRG1:
    hsa-mir-30a-5p (MIRT005215), hsa-mir-1 (MIRT023829)

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    1 qRT-PCR Assays for microRNA that regulate FRG1:
    hsa-miR-3607-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FRG1_HUMAN, Q14331: Nucleus, Cajal body. Nucleus speckle. Nucleus, nucleolus. Note=First expressed in Cajal
    bodies and nuclear speckles. As speckle expression diminishes, expression is seen in dense structures (dense
    fibrillar component and the granular component) of the nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0015030Cajal body IEA--
    GO:0016607nuclear speck IEA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with FRG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FRG1
    Interactions:

        Search GeneGlobe Interaction Network for FRG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FRG1 (Q143311, 2, 3 ENSP000002267984) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    ENSG00000235068Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006364rRNA processing IEA--

    Find genes that share ontologies with FRG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for FRG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FRG1 gene: 
    NM_004477.2  

    Unigene Cluster for FRG1:

    FSHD region gene 1
    Hs.203772  [show with all ESTs]
    Unigene Representative Sequence: BC053997
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226798(uc003izs.3) ENST00000524583 ENST00000533157 ENST00000531991
    ENST00000514482 ENST00000507103 ENST00000505327
    miRNA
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    hsa-miR-3607-3p
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    Additional mRNA sequence: 

    AK291890.1 BC053997.1 L76159.1 

    8 DOTS entries:

    DT.455547  DT.100037104  DT.80100373  DT.100037102  DT.100743505  DT.102845536  DT.120805807  DT.95333232 

    Selected AceView cDNA sequences (see all 157):

    AW303588 BI754635 BM972483 BM718034 AI217796 AA749391 AA381469 AW328678 
    BF593466 BM969973 BU194055 BU941325 BG566675 T51019 CD106556 BV208009 
    BQ575875 CO438922 BG776525 BE253002 BU658862 CB053602 AA643578 BP370742 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FRG1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                                      -           -         
    SP2:                                -                           
    SP3:              -     -                 -                     


    ECgene alternative splicing isoforms for FRG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FRG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACGCTTCT
    FRG1 Expression
    About this image


    FRG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    FRG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FRG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203772

    UniProtKB/Swiss-Prot: FRG1_HUMAN, Q14331
    Tissue specificity: Expressed in adult muscle, lymphocytes, fetal brain, muscle, and placenta

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FRG1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frg11 , 5 FSHD region gene 11, 5 90.18(n)1
    97.29(a)1
      8 (23.89 cM)5
    143001  NM_013522.31  NP_038550.21 
     413974575 
    chicken
    (Gallus gallus)
    Aves FRG11 FSHD region gene 1 79.69(n)
    84.37(a)
      422726  XM_420681.3  XP_420681.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    5(109409454-109422601)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.82032 Xenopus laevis transcribed sequence with moderate similarity more 78.37(n)    48053800 
    zebrafish
    (Danio rerio)
    Actinopterygii BM570995.12   -- 76.09(n)    BM570995.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64801 , 3 CG64801 51(a)3
    54.87(n)1
    51.89(a)1
      77B13
    402281  NM_140945.31  NP_649202.11 
    worm
    (Caenorhabditis elegans)
    Secernentea frg-11 frg-1 51.05(n)
    44.09(a)
      176719  NM_067295.4  NP_499696.2 


    ENSEMBL Gene Tree for FRG1 (if available)
    TreeFam Gene Tree for FRG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FRG1 gene
    ENSG000002200232  FRG1B2  
    Selected SIMAP similar genes for FRG1 using alignment to 5 protein entries:     FRG1_HUMAN (see all proteins) (see all similar genes):
    LOC283788    FRG1B    CALCOCO2    RBP7    EIF3G    RHBG
    TNNT1    C14orf105    IK    KIAA1651    ADCK1    C12orf76
    HC6    LSM12    SMYD4    AARSD1    CSPP1    HEXDC

    Find genes that share paralogs with FRG1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for FRG1
    PGOHUM00000236176 PGOHUM00000260520 PGOHUM00000260522


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FRG1 (see all 2006)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006202991,2
    Cuntested1190626968(+) AGGGCC/TCTAGT 2 P S mis10--------
    rs1999397161,2
    C--186612160(+) ATAGC-/TATTCT 1 -- int10--------
    rs346500211,2
    --186616113(+) AAAAA-/ACTGCG 1 -- int10--------
    rs1115645911,2
    C--186624655(+) TACCCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs788477211,2
    C--190612717(+) GAATTC/TTGCCT 1 -- us2k10--------
    rs730229981,2
    C--190612719(+) ATTCTC/G/TCCTTT 1 -- us2k11CSA 1
    rs1420984941,2
    C--190612742(+) TGTTC-/CCTCCTCC 1 -- us2k10--------
    rs746918651,2
    C--190612778(+) TTATGC/TAACTC 1 -- us2k10--------
    rs767179421,2
    C--190612807(+) AAGAGC/TTGAAA 1 -- us2k10--------
    rs37562851,2
    C,F,A,H--190612864(+) CGGTTT/AGAATA 1 -- us2k118Minor allele frequency- A:0.24NA NS EA WA CSA 1713

    HapMap Linkage Disequilibrium report for FRG1 (190861943 - 190884359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FRG1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665705CNV Deletion23128226
    nsv830182CNV Loss17160897
    dgv5873n71CNV Loss21882294
    nsv10641CNV Loss18304495
    dgv5877n71CNV Gain21882294
    dgv5875n71CNV Gain21882294
    nsv880818CNV Gain21882294
    dgv921n67CNV Gain20364138
    dgv5876n71CNV Gain21882294
    esv34388CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601278    OMIM disorders: --

    4 diseases for FRG1:    
    About MalaCards
    fascioscapulohumeral muscular dystrophy 2, digenic    suppurative lymphadenitis    facioscapulohumeral muscular dystrophy    muscular dystrophy

    2 diseases from the University of Copenhagen DISEASES database for FRG1:
    Facioscapulohumeral muscular dystrophy     Suppurative lymphadenitis

    Find genes that share disorders with FRG1           About GenesLikeMe

    2 Novoseek inferred disease relationships for FRG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular dystrophy facioscapulohumeral 95.4 8 20215405 (2), 19097195 (1), 16341202 (1), 19607661 (1) (see all 5)
    muscular dystrophies 72.2 4 9714712 (1), 19097195 (1), 9166581 (1), 16341202 (1)


    Export disorders for FRG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FRG1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with FRG1)
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    1. Identification of the first gene (FRG1) from the FSHD region on human chromosome 4q35. (PubMed id 8733123)1, 2, 3, 9 van Deutekom J.C.T.... Frants R.R. (Hum. Mol. Genet. 1996)
    2. FRG1P is localised in the nucleolus, Cajal bodies, and speckles. (PubMed id 15060122)1, 2 van Koningsbruggen S.... van der Maarel S.M. (J. Med. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. The FSHD region on human chromosome 4q35 contains potential coding regions among pseudogenes and a high density of repeat elements. (PubMed id 10512680)1, 2 van Geel M....de Jong P.J. (Genomics 1999)
    6. Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD-related gene 1 (FRG1) expression during human myogenic differentiation. (PubMed id 19607661)1, 9 Bodega B....Ginelli E. (BMC Biol. 2009)
    7. Muscular dystrophy candidate gene FRG1 is critical for muscle development. (PubMed id 19097195)1, 9 Hanel M.L....Jones P.L. (Dev. Dyn. 2009)
    8. Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1. (PubMed id 16341202)1, 9 Gabellini D....Tupler R. (Nature 2006)
    9. A functional role for 4qA/B in the structural rearrangement of the 4q35 region and in the regulation of FRG1 and ANT1 in facioscapulohumeral dystrophy. (PubMed id 18852887)1, 9 Pirozhkova I....Vassetzky Y. (PLoS ONE 2008)
    10. Molecular genetics of facioscapulohumeral muscular dystrophy (FSHD). (PubMed id 9132141)1, 9 Fisher J. and Upadhyaya M. (Neuromuscul. Disord. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2483 HGNC: 3954 AceView: FRG1 Ensembl:ENSG00000109536 euGenes: HUgn2483
    ECgene: FRG1 H-InvDB: FRG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FRG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FRG1 gene:
    Search GeneIP for patents involving FRG1

    GeneCards and IP:
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