FREM3 Gene
protein-coding GIFtS: 41
GCID: GC04M144498
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FRAS1 related extracellular matrix 3
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Aliases
for FREM3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FRAS1 Related Extracellular Matrix 31 2 | | FRAS1-Related Extracellular Matrix Protein 32 |
Export aliases for FREM3 gene to outside databasesPrevious GC identifers: GC04M144849 GC04M144717 GC04M140228 |
Summaries
for FREM3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FREM3_HUMAN, P0C091Function: Extracellular matrix protein which may play a role in cell adhesion (By similarity)
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Genomic Views
for FREM3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FREM3 gene promoter:
STAT5B ISGF-3 AML1a MIF-1 CUTL1 Nkx2-5 LCR-F1 C/EBPalpha CHOP-10 Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FREM3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FREM3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q31.21 Ensembl cytogenetic band: 4q31.21 HGNC cytogenetic band: 4q31.21FREM3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M144498: view genomic region
(about GC identifiers)
Start:
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144,498,455 bp from pter |
End:
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144,621,828 bp from pter |
Size:
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123,374 bases |
Orientation:
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minus strand |
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Proteins
for FREM3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FREM3_HUMAN, P0C091 (See
protein sequence)Recommended Name: FRAS1-related extracellular matrix protein 3 precursor Size: 2139 amino acids; 238179 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)Explore the universe of human proteins at neXtProt for FREM3: NX_P0C091
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C091
FREM3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001161707.1
ENSEMBL proteins: ENSP00000332886
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005604 | basement membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | | GO:0031012 | colocalizes with extracellular matrix |
TAS | -- |
FREM3 for ontologies About GeneDecksing
FREM3 Antibody Products:
Assay Products for FREM3: |
Protein
Domains /
Families
for FREM3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FREM3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0C091ProtoNet protein and cluster: P0C091 UniProtKB/Swiss-Prot: FREM3_HUMAN, P0C091Domain: The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding (Bysimilarity)Similarity: Belongs to the FRAS1 familySimilarity: Contains 3 Calx-beta domainsSimilarity: Contains 12 CSPG (NG2) repeats |
Function
for FREM3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FREM3_HUMAN, P0C091Function: Extracellular matrix protein which may play a role in cell adhesion (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FREM3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FREM3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FREM3 (NM_001168235) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FREM3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FREM3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FREM3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
FREM3 for ontologies About GeneDecksing
|
Pathways & Interactions
for FREM3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FREM3
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007154 | cell communication |
IEA | -- | | GO:0007155 | cell adhesion |
IEA | -- |
FREM3 for ontologies About GeneDecksing
|
Drugs & Compounds
for FREM3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FREM3
1 HMDB Compound for FREM3 About this table
Search CenterWatch for drugs/clinical trials and news about FREM3
|
Transcripts
for FREM3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FREM3 gene: NM_001168235.1 Unigene Cluster for FREM3: FRAS1 related extracellular matrix 3 Hs.252714 [show with all ESTs]Unigene Representative Sequence: NM_0011682352 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329798(uc021xsj.1) ENST00000508899
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FREM3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FREM3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FREM3 (NM_001168235) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FREM3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FREM3 |
2 DOTS entries: DT.436368 DT.439230 10 AceView cDNA sequences: Z43936 BE223071 AW953229 AA350251 T33332 R44016 H09749 R19117 R44783 R19029
GeneLoc Exon Structure
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Expression
for FREM3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FREM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FREM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FREM3
SOURCE GeneReport for Unigene cluster: Hs.252714
SABiosciences Custom PCR Arrays for FREM3
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FREM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FREM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FREM3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FREM3 |
Orthologs
for FREM3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FREM3 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for FREM3 (if available)
TreeFam Gene Tree for FREM3 (if available) |
Paralogs
for FREM3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FREM3 gene
- FREM22 CSPG42 FREM12 FRAS12
2 SIMAP similar genes for FREM3 using alignment to 2 protein entries: FREM3_HUMAN (see all proteins):FREM2 FREM1
FREM3 for paralogs About GeneDecksing
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Genomic Variants
for FREM3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for FREM3
1 CNV: 3519
4 Indels: 12563 62270 42217 40695
Human Gene Mutation Database (HGMD): FREM3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FREM3 |
|
Disorders
/ Diseases
for FREM3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FREM3 for disorders About GeneDecksing
OMIM gene information: 608946
OMIM disorders: --
3  diseases for FREM3: About MalaCardsrenal agenesis fraser syndrome syndactyly
2 diseases from the University of Copenhagen DISEASES database for FREM3:Renal agenesis Syndactyly Export disorders for FREM3 gene to outside databases
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Publications
for FREM3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FREM3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FREM3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. (PubMed id 15345741)1, 2, 3 Smyth I.... Jackson I.J. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- A study of the combined effects of the EHD3 and FREM3 genes in patients with major depressive disorder. (PubMed id 22337703)1 Shi C....Xu Q. (2012)
- Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa. (PubMed id 17596926)9 Petrou P....Chalepakis G. (2007)
- The Fras1/Frem family of extracellular matrix proteins: structure, function, and association with Fraser syndrome and the mouse bleb phenotype. (PubMed id 18661360)9 Petrou P....Chalepakis G. (2008)
- Ultrastructural localization of Fras1 in the sublamina densa of embryonic epithelial basement membranes. (PubMed id 17576586)9 Dalezios Y....Chalepakis G. (2007)
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External Searches for FREM3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FREM3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FREM3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FREM3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FREM3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FREM3 gene:
Search GeneIP for patents involving FREM3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FREM3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FREM3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FREM3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FREM3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FREM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FREM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FREM3 |
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 |  |  |  | |
| | | | Search Tocris compounds for FREM3 |
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 | | | FREM3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FREM3 |
|  |  |  | | | | Search ThermoFisher Antibodies for FREM3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FREM3 |
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