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FREM2 Gene

protein-coding   GIFtS: 54
GCID: GC13P039261

FRAS1 Related Extracellular Matrix Protein 2

  See FREM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FRAS1 Related Extracellular Matrix Protein 21 2
ECM3 Homolog2 3
FRAS1-Related Extracellular Matrix Protein 22

External Ids:    HGNC: 253961   Entrez Gene: 3416402   Ensembl: ENSG000001508937   OMIM: 6089455   UniProtKB: Q5SZK83   

Export aliases for FREM2 gene to outside databases

Previous GC identifers: GC13P038159 GC13P020059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FREM2 Gene:
This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is
thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal
epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in
epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser
syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for FREM2 Gene:
FREM2 (FRAS1 related extracellular matrix protein 2) is a protein-coding gene. Diseases associated with FREM2 include frem2-related fraser syndrome, and unilateral renal agenesis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CSPG4.

UniProtKB/Swiss-Prot: FREM2_HUMAN, Q5SZK8
Function: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for
maintenance of renal epithelia. May be required for epidermal adhesion

Gene Wiki entry for FREM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the FREM2 gene promoter:
         p53   GCNF   NRSF form 1   Nkx2-5   NRSF form 2   GATA-1   SRY   GCNF-1   GCNF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FREM2 promoter sequence
   Search Chromatin IP Primers for FREM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FREM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.3   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.3

FREM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FREM2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P039261:  view genomic region     (about GC identifiers)

Start:
39,261,173 bp from pter      End:
39,461,268 bp from pter
Size:
200,096 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FREM2_HUMAN, Q5SZK8 (See protein sequence)
Recommended Name: FRAS1-related extracellular matrix protein 2 precursor  
Size: 3169 amino acids; 351157 Da
Sequence caution: Sequence=BAC87040.1; Type=Erroneous initiation;
Secondary accessions: Q4QQG1 Q5H9N8 Q5T6Q1 Q6N057 Q6ZSB4 Q7Z305 Q7Z341
Alternative splicing: 2 isoforms:  Q5SZK8-1   Q5SZK8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FREM2: NX_Q5SZK8

Explore proteomics data for FREM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn358, Asn1244, Asn1369, Asn1584, Asn1741, Asn2121
  • Modification sites at PhosphoSitePlus

  • See FREM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_997244.3  
    ENSEMBL proteins: 
     ENSP00000280481  

    FREM2 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for FREM2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003644 Calx_beta
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q5SZK8

    ProtoNet protein and cluster: Q5SZK8

    UniProtKB/Swiss-Prot: FREM2_HUMAN, Q5SZK8
    Domain: The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon
    binding (By similarity)
    Similarity: Belongs to the FRAS1 family
    Similarity: Contains 5 Calx-beta domains
    Similarity: Contains 12 CSPG (NG2) repeats


    Find genes that share domains with FREM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FREM2_HUMAN, Q5SZK8
    Function: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for
    maintenance of renal epithelia. May be required for epidermal adhesion

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with FREM2           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Frem2):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  hearing/vestibular/ear 
     integument  limbs/digits/tail  mortality/aging  nervous system  pigmentation 
     renal/urinary system  reproductive system  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with FREM2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FREM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FREM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FREM2
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    miRNA
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    miRTarBase miRNAs that target FREM2:
    hsa-mir-615-3p (MIRT040156), hsa-mir-29c-3p (MIRT020399)

    Block miRNA regulation of human, mouse, rat FREM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FREM2 (see all 45):
    hsa-miR-607 hsa-let-7d hsa-miR-429 hsa-miR-29a hsa-miR-628-3p hsa-let-7g hsa-miR-9 hsa-let-7a
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FREM2_HUMAN, Q5SZK8: Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FREM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FREM2
    Interactions:

        GeneGlobe Interaction Network for FREM2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for FREM2 (Q5SZK83 ENSP000002804814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    GRIP1Q9Y3R03I2D: score=1 
    STK3Q131883I2D: score=1 
    ADCK2ENSP000000728694STRING: ENSP00000072869
    FXNENSP000003664824STRING: ENSP00000366482
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002009morphogenesis of an epithelium IEA--
    GO:0007154cell communication IEA--
    GO:0007156homophilic cell adhesion IEA--
    GO:0048839inner ear development IEA--

    Find genes that share ontologies with FREM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FREM2

    1 HMDB Compound for FREM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FREM2 gene: 
    NM_207361.4  

    Unigene Cluster for FREM2:

    FRAS1 related extracellular matrix protein 2
    Hs.253994  [show with all ESTs]
    Unigene Representative Sequence: NM_207361
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280481(uc001uwv.3 uc001uww.3) ENST00000482551
    miRNA
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    Block miRNA regulation of human, mouse, rat FREM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FREM2 (see all 45):
    hsa-miR-607 hsa-let-7d hsa-miR-429 hsa-miR-29a hsa-miR-628-3p hsa-let-7g hsa-miR-9 hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FREM2
      QuantiTect SYBR Green Assays in human, mouse, rat FREM2
      QuantiFast Probe-based Assays in human, mouse, rat FREM2

    Additional mRNA sequence: 

    AK127571.1 BX538150.1 BX538304.1 BX640686.1 CR933724.1 

    4 DOTS entries:

    DT.75169242  DT.101956127  DT.95073344  DT.101957386 

    Selected AceView cDNA sequences (see all 30):

    NM_207361 AI289430 AW612422 BF431464 BQ719838 AI913099 CD655887 AW194836 
    BX538150 AI274791 AI375575 BX538304 AI370601 BX640686 AW303485 AK127571 
    BF476132 AL708377 BG484526 AA448605 AW858448 BM983495 AL119393 AW242548 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FREM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTAGTTC
    FREM2 Expression
    About this image


    FREM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             hIPS1
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    FREM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FREM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.253994
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FREM2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frem21 , 5 Fras1 related extracellular matrix protein 21, 5 83.6(n)1
    88.52(a)1
      3 (25.24 cM)5
    2420221  NM_172862.31  NP_766450.21 
     535139395 
    chicken
    (Gallus gallus)
    Aves FREM21 FRAS1 related extracellular matrix protein 2 73.75(n)
    77.7(a)
      418893  XM_417087.4  XP_417087.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    many ↔ many
    4(101143619-101300573)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004966961 FRAS1-related extracellular matrix protein 2-like 70.78(n)
    73.29(a)
      100496696  XM_004911976.1  XP_004912033.1 
    zebrafish
    (Danio rerio)
    Actinopterygii frem2b1 Fras1 related extracellular matrix protein 2b 66.47(n)
    69.9(a)
      566673  NM_001137661.1  NP_001131133.1 


    ENSEMBL Gene Tree for FREM2 (if available)
    TreeFam Gene Tree for FREM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FREM2 gene
    CSPG42  FREM12  FREM32  FRAS12  
    2 SIMAP similar genes for FREM2 using alignment to 1 protein entry:     FREM2_HUMAN:
    FREM3    FRAS1

    Find genes that share paralogs with FREM2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FREM2
    PGOHUM00000248518 PGOHUM00000245716


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FREM2 (see all 4517)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0232014
    Fraser syndrome (FRASS)4--see VAR_0232012 E K mis40--------
    rs1144093051,2
    Cuntested120210358(+) TTATTC/TGTTAT 2 R C mis11Minor allele frequency- T:0.01EA 208
    rs718081601,2
    C--20085214(+) TCTCTCACA/-  
            
    CACAC
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs79937691,2
    C,F,A,H--20085215(+) CTCTCT/ACACAC 1 -- int13Minor allele frequency- A:0.50NA WA 6
    rs1468433281,2
    C--20091223(+) AAAAA-/ATTACT 1 -- int10--------
    rs1422992761,2
    C--20094922(+) GCCCA-/AT    
       
    /ATAT
    ATATA
    1 -- int10--------
    rs106891081,2
    C--20094939(+) TATAT-/AT    
       
    /ATAT
    GTTTT
    1 -- int10--------
    rs58029551,2
    C--20095307(+) TTTTT-/T/TT  
            
    CATCC
    1 -- int1 trp30--------
    rs113462821,2
    C--20101260(+) AACCA-/CCCGTA 1 -- int12Minor allele frequency- C:0.00NA CSA 4
    rs113673111,2
    C--20105875(+) AGTGG-/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.00CSA 2

    HapMap Linkage Disequilibrium report for FREM2 (39261173 - 39461268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FREM2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660903CNV Deletion23128226
    esv4433CNV Deletion18987735
    esv2665365CNV Deletion23128226
    esv2747283CNV Deletion23290073
    esv2747282CNV Deletion23290073
    esv272674CNV Insertion20981092
    esv271338CNV Insertion20981092
    nsv507692CNV Insertion20534489
    nsv1008CNV Loss18451855
    nsv64239CNV Loss16902084

    Human Gene Mutation Database (HGMD): FREM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FREM2
    DNA2.0 Custom Variant and Variant Library Synthesis for FREM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608945   
    OMIM disorders: 219000  
    UniProtKB/Swiss-Prot: FREM2_HUMAN, Q5SZK8
  • Fraser syndrome (FRASS) [MIM:219000]: Multisystem malformation usually comprising cryptophthalmos,
    cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 4 diseases for FREM2:    
    About MalaCards
    frem2-related fraser syndrome    unilateral renal agenesis    fraser syndrome    macrostomia

    2 diseases from the University of Copenhagen DISEASES database for FREM2:
    Syndactyly     Renal agenesis

    Find genes that share disorders with FREM2           About GenesLikeMe

    1 Novoseek inferred disease relationship for FREM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fraser syndrome 93.3 2 17596926 (1), 18563433 (1), 18155042 (1), 17251066 (1) (see all 7)

    Genetic Association Database (GAD): FREM2

    Export disorders for FREM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FREM2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with FREM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response. (PubMed id 21993531)1, 4 Kuparinen T....Hurme M. (Genes Immun. 2012)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    3. Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. (PubMed id 15838507)1, 2 Jadeja S....Scambler P.J. (Nat. Genet. 2005)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    5. The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. (PubMed id 15345741)1, 3 Smyth I.... Jackson I.J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Molecular study of 33 families with Fraser syndrome new data and mutation review. (PubMed id 18671281)1, 9 van Haelst M.M....Scambler P.J. (Am. J. Med. Genet. A 2008)
    8. Identification of two novel CAKUT-causing genes by massively parallel exon resequencing of candidate genes in patients with unilateral renal agenesis. (PubMed id 21900877)1 Saisawat P....Hildebrandt F. (Kidney Int. 2012)
    9. Amplification of the STOML3, FREM2, and LHFP genes is associated with mesenchymal differentiation in gliosarcoma. (PubMed id 22538188)1 Nagaishi M....Ohgaki H. (Am. J. Pathol. 2012)
    10. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (J. Cell Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 341640 HGNC: 25396 AceView: FREM2 Ensembl:ENSG00000150893 euGenes: HUgn341640
    ECgene: FREM2 H-InvDB: FREM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FREM2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FREM2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FREM2 gene:
    Search GeneIP for patents involving FREM2

    GeneCards and IP:
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