FREM1 Gene

Aliases
for FREM1 gene

Summaries
for FREM1 gene

Genomic Views
for FREM1 gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008413.18  

SwitchGear Promoter luciferase reporter plasmids (see all 2): FREM1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FREM1

FREM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M014730:  view genomic region     (about GC identifiers)

Proteins
for FREM1 gene

Explore the universe of human proteins at neXtProt for FREM1: NX_Q5H8C1

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for FREM1 (QBRICK/FREM1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FREM1 OriGene Protein Over-expression Lysate: FREM1 OriGene Custom Protein Services for FREM1
	GenScript Custom Purified and Recombinant Proteins Services for FREM1
	Novus Biologicals FREM1 Protein Novus Biologicals FREM1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FREM1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for FREM1
	GenScript Custom Superior Antibodies Services for FREM1
	Novus Biologicals FREM1 Antibody
	Search for Antibodies for FREM1 at Abcam
	Uscn Antibodies for FREM1
	ThermoFisher Antibodies for FREM1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FREM1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FREM1

Protein Domains /
Families
for FREM1 gene

ProtoNet protein and cluster: Q5H8C1

Function
for FREM1 gene

miRNA Products:		OriGene 3'-UTR Clone: FREM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FREM1
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate FREM1 (see all 24):
		hsa-miR-539 hsa-miR-429 hsa-miR-29a hsa-miR-29c hsa-miR-1271 hsa-miR-374a hsa-miR-340 hsa-miR-205*
		SwitchGear 3'UTR luciferase reporter plasmid: FREM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FREM1 (see all 4) OriGene shRNA RFP: FREM1 OriGene siRNA: FREM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FREM1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FREM1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FREM1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FREM1 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): FREM1 (NM_144966)
		Sino Biological Human cDNA Clone for FREM1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FREM1
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FREM1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FREM1
		Search LifeMap BioReagents cell lines for FREM1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FREM1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 5 alleles) (MGI details for Frem1)

Pathways & Interactions
for FREM1 gene

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for FREM1 gene

Transcripts
for FREM1 gene

Expression
for FREM1 gene

FREM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCCACTG

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeInner Nuclear LayernGnG Amacrine Cells			Amacrine, Retina
	Neural TubeTelencephalon			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 6 LifeMap Cells
	Name			Category
	N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
	Trophoblast-like cells (Generation of tropho...)
	Definitive endoderm-like cells (Generation and expan...)
	Definitive endoderm-like cells (Generation of mesend...)
	Mesendoderm-like cells (Generation of mesend...)
	Definitive endoderm-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FREM1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FREM1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FREM1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FREM1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FREM1

Orthologs
for FREM1 gene

Paralogs
for FREM1 gene

Paralogs for FREM1 gene

FREM2²  CSPG4²  FREM3²  FRAS1²  

1 SIMAP similar gene for FREM1 using alignment to 4 protein entries:     FREM1_HUMAN (see all proteins):

FREM3

FREM1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for FREM1
PGOHUM00000244050

Genomic Variants
for FREM1 gene

10/4076 NCBI SNPs in FREM1 are shown (see all 4076)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1134659221,2		--	14697807(+)	GGATGC/TATGGA	2	--	ds5001		1		CSA	2
rs1120506511,2	C,	--	14698230(+)	TTATTG/TTTAGC	2	--	ut31		1		WA	2
rs70333711,2	C,F,A,H,	--	14698437(+)	TCTGTT/CCAACC	2	--	ut31		13		NA NS EA WA CSA	804
rs70477121,2	C,F,H,	--	14698484(+)	TTCTAC/TCCATT	2	--	ut31		25		NA NS EA WA CSA	2710
rs70335201,2	H	--	14698579(+)	CTGAGT/CCAAAG	2	--	ut31		4		NS EA	418
rs109616881,2		--	14698847(+)	GCTGAC/TAAGGT	2	--	ut31		0	--	--	--	--
rs782077031,2	F,	--	14699226(+)	ATAGAC/TAGAAT	2	--	ut31		1		WA	118
rs117895041,2	C,F,A,H,	--	14699435(+)	CCCCAA/TTTTGA	2	--	ut31		13		NA NS EA WA	804
rs1175379451,2	C,F,	--	14699667(+)	TTTCCG/ATTAGA	2	--	ut31		1		NA	120
rs773413631,2	C,	--	14699706(+)	ATATTA/CAAGAT	2	--	ut31		3		NA WA	240

HapMap Linkage Disequilibrium report for FREM1 (14734664 - 14910993 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for FREM1
     3 CNVs: 6680 100591 4615
     2 Indels: 59518 47686
Human Gene Mutation Database (HGMD): FREM1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FREM1

DNA2.0 Custom Variant and Variant Library Synthesis for FREM1

Disorders / Diseases
for FREM1 gene

Publications
for FREM1 gene

PubMed articles for FREM1 gene, integrated from 9 sources (see all 28): (articles sorted by number of sources associating them with FREM1)

Utopia: connect your pdf to the dynamic world of online information

1. Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. (PubMed id 21507892)^{1, 2} Slavotinek A.M....Zenker M. (2011)
2. Heterozygous mutations of FREM1 are associated with a n increased risk of isolated metopic craniosynostosis in humans and mice. (PubMed id 21931569)^{1, 2} Vissers L.E....Roscioli T. (2011)
3. FREM1 mutations cause bifid nose, renal agenesis, and anorectal malformations syndrome. (PubMed id 19732862)^{1, 2} Alazami A.M....Alkuraya F.S. (2009)
4. Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle. (PubMed id 15878328)^{1, 2} Kiyozumi D.... Sekiguchi K. (2005)
5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
6. The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. (PubMed id 15345741)^{1, 3} Smyth I.... Jackson I.J. (2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
9. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)^{1, 3} Puente X.S.... Lopez-Otin C. (2003)
10. A genetic polymorphism of FREM1 is associated with res istance against HIV infection in the Pumwani sex worker cohort. (PubMed id 22915813)¹ Luo M....Plummer F.A. (2012)

External Searches for FREM1 gene

Genome Databases showing FREM1 gene

Other Databases showing FREM1 gene

Specialized Databases showing FREM1 gene

Products
for FREM1 gene