FRAXE Gene
uncategorized GIFtS: 18
GCID: GC0XU990061
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fragile site, folic acid type, rare, fra(X)(q28) E
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Aliases
for FRAXE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| Fragile Site, Folic Acid Type, Rare, Fra(X)(Q28) E1 2 | | FMR22 5 | | AFF25 | | MRX25 |
Export aliases for FRAXE gene to outside databases |
Summaries
for FRAXE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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-- |
Genomic Views
for FRAXE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FRAXE
Other transcription factors
Search SABiosciences Chromatin IP Primers for FRAXE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRAXE |
Genomic Location:
Chromosome:X
Entrez Gene cytogenetic band: Xq28 HGNC cytogenetic band: Xq28GeneLoc information about chromosome X |
Proteins
for FRAXE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for FRAXE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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Function
for FRAXE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
Genatlas biochemistry entry for FRAXE:fragile site,folic acid type,rare,fra(X)(q28) with polymorphic GCC (CGG) repeat
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for FRAXE | |  | Search LifeMap BioReagents cell lines for FRAXE | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRAXE |
Pathways & Interactions
for FRAXE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FRAXE
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Drugs & Compounds
for FRAXE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for FRAXE
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Transcripts
for FRAXE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Expression
for FRAXE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for FRAXE
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FRAXE | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRAXE | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRAXE | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRAXE |
Orthologs
for FRAXE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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Paralogs
for FRAXE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for FRAXE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for FRAXE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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FRAXE for disorders About GeneDecksing
OMIM gene information: 300806
OMIM disorders: 309548
9  diseases for FRAXE: About MalaCardsmental retardation, x-linked, fraxe type mental retardation, x-linked fragile x syndrome pervasive developmental disorder
x-linked disease premature ovarian failure intellectual disability parkinson's disease
twinning
2 Novoseek disease relationships for FRAXE gene About this table
Genatlas disease: FRAXE mental retardation,X-linked,mild,associated with fragile site FRAXE and loss of FMR2 expression correlated with FRAXEexpression
Genetic Association Database (GAD): FRAXE
Human Genome Epidemiology (HuGE) Navigator: FRAXE (11 documents)
Export disorders for FRAXE gene to outside databases
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Publications
for FRAXE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for FRAXE gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with FRAXE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fragile X syndrome: a clinico-genetic study of mentally retarded patients in Kuwait. (PubMed id 16201716)1, 4 Bastaki L.A....Naguib K.K. (2004)
- FRAXE intermediate alleles are associated with Parkinson's disease. (PubMed id 15342126)1, 4 Annesi G....Quattrone A. (2004)
- Genetic and neurological evaluation in a sample of individuals with pervasive developmental disorders. (PubMed id 12806492)1, 4 Steiner C.E....Marques-de-Faria A.P. (2003)
- [Polymorphism of trinucleotide repeats at loci FRAXA and FRAXE in the population of Tomsk] (PubMed id 11898618)1, 4 Tolmacheva E.N. and Nazarenko S.A. (2002)
- Three families with high expression of a fragile site at Xq27.3, lack of anomalies at the FMR-1 CpG island, and no clear phenotypic association. (PubMed id 1605195)1, 3 Oberle I....Mandel J.L. (1992)
- Familial intellectual disability and autistic behavior caused by a small FMR2 gene deletion. (PubMed id 21739600)1 Stettner G.M.... Auber B. (2011)
- Intermediate alleles at the FRAXA and FRAXE loci in P arkinson's disease. (PubMed id 21257332)1 Costa A....Pintado E. (2011)
- A late origin of DNA replication in the trinucleotide repeat region of the human FMR2 gene. (PubMed id 16582587)1 Chastain P.D....Kaufman D.G. (2006)
- [Polymorphism of CGG repeats in the FRAXE fragile site in the Qinba Mountain area children and its association with intelligence] (PubMed id 17035177)1 Niu Y.B....Zhang F.C. (2006)
- Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE. (PubMed id 8755928)4 Subramanian P.S....Chinault A.C. (1996)
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External Searches for FRAXE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FRAXE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing FRAXE gene
(According to HUGE)
About This Section
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Specialized Databases showing FRAXE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for FRAXE | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FRAXE gene:
Search GeneIP for patents involving FRAXE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FRAXE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FRAXE | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRAXE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRAXE | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRAXE | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRAXE | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRAXE |
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| | | | Search Tocris compounds for FRAXE |
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 | | | FRAXE Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRAXE |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FRAXE |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FRAXE |
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