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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FRAT2 Gene

protein-coding   GIFtS: 54
GCID: GC10M099082

Frequently Rearranged In Advanced T-Cell Lymphomas 2

  Search for FRAT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Frequently Rearranged In Advanced T-Cell Lymphomas 21 2 3
GSK-3 Binding Protein FRAT21 2
FRAT-22 3
GSK-3-Binding Protein FRAT22

External Ids:    HGNC: 160481   Entrez Gene: 234012   Ensembl: ENSG000001812747   OMIM: 6050065   UniProtKB: O754743   

Export aliases for FRAT2 gene to outside databases

Previous GC identifers: GC10M097985 GC10M098325 GC10M099223 GC10M098756 GC10M092717


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FRAT2 Gene:
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this
protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor
progression. (provided by RefSeq, Jul 2008)

GeneCards Summary for FRAT2 Gene: 
FRAT2 (frequently rearranged in advanced T-cell lymphomas 2) is a protein-coding gene. Among its related super-pathways are Wnt Signaling Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include molecular_function. An important paralog of this gene is FRAT1.

UniProtKB/Swiss-Prot: FRAT2_HUMAN, O75474
Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with
GSK-3

Gene Wiki entry for FRAT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FRAT2 gene promoter:
         COUP-TF1   STAT1   COUP-TF   Zic1   COUP   STAT3   STAT1beta   STAT1alpha   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FRAT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FRAT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23-q24.1

FRAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRAT2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M099082:  view genomic region     (about GC identifiers)

Start:
99,092,254 bp from pter      End:
99,094,458 bp from pter
Size:
2,205 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FRAT2_HUMAN, O75474 (See protein sequence)
Recommended Name: GSK-3-binding protein FRAT2  
Size: 233 amino acids; 24051 Da
Subunit: Binds GSK-3 and prevents GSK-3-dependent phosphorylation
Secondary accessions: Q5JTI0 Q8WUL9 Q9BYG2

Explore the universe of human proteins at neXtProt for FRAT2: NX_O75474

Explore proteomics data for FRAT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75474

  • FRAT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FRAT2 Protein Expression
    REFSEQ proteins: NP_036215.1  
    ENSEMBL proteins: 
     ENSP00000360058  

    Human Recombinant Protein Products for FRAT2: 
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    Novus Biologicals FRAT2 Protein
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    Cloud-Clone Corp. Proteins for FRAT2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    FRAT2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008014 GSK3-bd

    Graphical View of Domain Structure for InterPro Entry O75474

    ProtoNet protein and cluster: O75474

    1 Blocks protein domain: IPB008014 Glycogen synthase kinase-3 binding protein

    UniProtKB/Swiss-Prot: FRAT2_HUMAN, O75474
    Similarity: Belongs to the GSK-3-binding protein family


    FRAT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FRAT2_HUMAN, O75474
    Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with
    GSK-3

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    FRAT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Frat2):
     normal 

    FRAT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FRAT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FRAT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FRAT2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FRAT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FRAT2
        GSK3 Signaling

    1 BioSystems Pathway for FRAT2
        Wnt Signaling Pathway NetPath


    1         Kegg Pathway  (Kegg details for FRAT2):
        Wnt signaling pathway


    FRAT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FRAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for FRAT2 (O754743 ENSP000003600584) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498413, ENSP000003248064I2D: score=3 STRING: ENSP00000324806
    CTNNB1P352223I2D: score=1 
    NKD1Q969G93I2D: score=1 
    AXIN1ENSP000002623204STRING: ENSP00000262320
    FRAT1ENSP000003600604STRING: ENSP00000360060
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development NAS9635432
    GO:0008283cell proliferation NAS9635432
    GO:0016055Wnt receptor signaling pathway IEA--

    FRAT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FRAT2

    Search CenterWatch for drugs/clinical trials and news about FRAT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FRAT2 gene: 
    NM_012083.2  

    Unigene Cluster for FRAT2:

    Frequently rearranged in advanced T-cell lymphomas 2
    Hs.140720  [show with all ESTs]
    Unigene Representative Sequence: NM_012083
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371019(uc001knd.1)
    miRNA
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    hsa-miR-4291 hsa-miR-498 hsa-miR-4251 hsa-miR-539 hsa-miR-29a hsa-miR-29c hsa-miR-221 hsa-miR-507
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    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRAT2

    Additional mRNA sequence: 

    AB045118.1 AF062739.1 BC020165.1 BT009770.1 

    1 DOTS entry:

    DT.309712 

    24/70 AceView cDNA sequences (see all 70):

    CK430396 AB045118 BE349056 AI351188 BQ652802 BQ652164 NM_012083 AW627431 
    BU845891 AF062739 BM853468 BU162649 BC020165 AA594265 AW965899 BQ064683 
    BQ955169 BU173477 BQ651734 CD514830 AW001094 AI276054 AW769912 AI222298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FRAT2 expression in normal human tissues (normalized intensities)      FRAT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTCGGCC
    FRAT2 Expression
    About this image


    FRAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             brain/midbrain   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Eye (Sensory Organs)
             Retina

    See FRAT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FRAT2

    SOURCE GeneReport for Unigene cluster: Hs.140720
        SABiosciences Custom PCR Arrays for FRAT2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FRAT2 gene from 3/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Frat21 , 5 frequently rearranged in advanced T cell lymphomas more1, 5 79.94(n)1
    76.62(a)1
      19 (35.33 cM)5
    2123981  NM_177603.31  NP_808271.11 
     418459785 
    African clawed frog
    (Xenopus laevis)
    Amphibia AF062738.12   -- 74.3(n)    AF062738.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gbp6
    glycogen synthase kinase binding protein
    39(a)
    1 → many
    16(43620065-43621408)


    ENSEMBL Gene Tree for FRAT2 (if available)
    TreeFam Gene Tree for FRAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FRAT2 gene
    FRAT12  
    1 SIMAP similar gene for FRAT2 using alignment to 1 protein entry:     FRAT2_HUMAN:
    FRAT1

    FRAT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/88 SNPs in FRAT2 are shown (see all 88)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9451891,2
    C,F,O,A,H--99091766(+) TCTAAG/CCCCTG 1 -- ds500116Minor allele frequency- C:0.46MN NS EA NA WA 1156
    rs122676711,2
    C--99091770(+) ACCCCT/CGAGTG 1 -- ds50012Minor allele frequency- C:0.08CSA WA 120
    rs733288061,2
    C,F--99091996(+) ATACAT/CTGTCT 1 -- ds50012Minor allele frequency- C:0.09WA 120
    rs1396868481,2
    C--99092133(+) GCATTA/GGCCCA 1 -- ds50010--------
    rs608225791,2
    C--99092165(+) CCCCC-/CC    
       CC
    /CG
    GTTTA
    1 -- ds50011NA 2
    rs111891341,2
    C--99092166(+) CCCCCC/GGTTTA 1 -- ds50012Minor allele frequency- G:0.25WA NA 4
    rs113311371,2
    C,F--99092166(+) CCCCGG/-TTTAG 1 -- ds50012Minor allele frequency- -:0.50NA 4
    rs1143608541,2
    F--99092238(+) CACCAA/TAATGC 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs37405181,2
    C,F,H--99092372(+) TGGAGG/AATGAA 1 -- ut31 ese36Minor allele frequency- A:0.01EA NS NA 524
    rs1837721511,2
    C--99092411(+) TTAGCC/TACCTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FRAT2 (99092254 - 99094458 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FRAT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29863CNV Loss19812545
    nsv831952CNV Loss17160897
    dgv169n67CNV Gain20364138
    nsv895914CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FRAT2 for disorders           About MalaCards
    OMIM gene information: 605006    OMIM disorders: --


    FRAT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FRAT2
    Human Genome Epidemiology (HuGE) Navigator: FRAT2 (2 documents)

    Export disorders for FRAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FRAT2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with FRAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. (PubMed id 11237732)1, 2, 3 Saitoh T....Katoh M. (2001)
    2. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. (PubMed id 9635432)1, 2, 3 Yost C....Kimelman D. (1998)
    3. Association between polymorphisms in Wnt signaling pa thway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1, 4 Lee D.Y....Kim J.G. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. (PubMed id 15522877)1, 9 Stoothoff W.H....Johnson G.V. (2005)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. (PubMed id 17433504)1 Liu G.P....Wang J.Z. (2008)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. (PubMed id 12095675)1 Freemantle S.J....Dmitrovsky E. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23401 HGNC: 16048 AceView: FRAT2 Ensembl:ENSG00000181274 euGenes: HUgn23401
    ECgene: FRAT2 Kegg: 23401 H-InvDB: FRAT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FRAT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FRAT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FRAT2 gene:
    Search GeneIP for patents involving FRAT2

    GeneCards and IP:
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