FRAT2 Gene
protein-coding GIFtS: 54
GCID: GC10M099082
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|
frequently rearranged in advanced T-cell lymphomas 2
| |
Aliases
for FRAT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Frequently Rearranged In Advanced T-Cell Lymphomas 21 2 3 | | FRAT-22 3 | | GSK-3 Binding Protein FRAT22 | | GSK-3-Binding Protein FRAT22 |
Export aliases for FRAT2 gene to outside databasesPrevious GC identifers: GC10M097985 GC10M098325 GC10M099223 GC10M098756 GC10M092717 |
Summaries
for FRAT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FRAT2:
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this proteinplays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FRAT2_HUMAN, O75474Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3
Gene Wiki entry for FRAT2
|
Genomic Views
for FRAT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FRAT2 gene promoter:
COUP-TF1 STAT1 COUP-TF Zic1 COUP STAT3 STAT1beta STAT1alpha HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FRAT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRAT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.1 Ensembl cytogenetic band: 10q24.1 HGNC cytogenetic band: 10q23-q24.1FRAT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M099082: view genomic region
(about GC identifiers)
Start:
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99,092,254 bp from pter |
End:
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99,094,458 bp from pter |
Size:
|
2,205 bases |
Orientation:
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minus strand |
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Proteins
for FRAT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FRAT2_HUMAN, O75474 (See
protein sequence)Recommended Name: GSK-3-binding protein FRAT2 Size: 233 amino acids; 24051 Da
Subunit: Binds GSK-3 and prevents GSK-3-dependent phosphorylation
Secondary accessions: Q5JTI0 Q8WUL9 Q9BYG2Explore the universe of human proteins at neXtProt for FRAT2: NX_O75474
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75474
FRAT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036215.1
ENSEMBL proteins: ENSP00000360058
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
FRAT2 for ontologies About GeneDecksing
FRAT2 Antibody Products:
Assay Products for FRAT2: |
Protein
Domains /
Families
for FRAT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FRAT2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75474ProtoNet protein and cluster: O75474 1 Blocks protein family: IPB008014 Glycogen synthase kinase-3 binding protein
UniProtKB/Swiss-Prot: FRAT2_HUMAN, O75474Similarity: Belongs to the GSK-3-binding protein family |
Function
for FRAT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FRAT2_HUMAN, O75474Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRAT2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FRAT2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRAT2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRAT2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
FRAT2 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Frat2):
FRAT2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FRAT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Wnt Signaling Pathway | | | 2 | Nanog in Mammalian ESC Pluripotency | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FRAT2
1  BioSystems Pathway for FRAT2
1 
Kegg Pathway (Kegg details for FRAT2):
FRAT2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FRAT2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for FRAT2 (O754743 ENSP000003600584) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FRAT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FRAT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FRAT2
Search CenterWatch for drugs/clinical trials and news about FRAT2
|
Transcripts
for FRAT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FRAT2 gene: NM_012083.2 Unigene Cluster for FRAT2: Frequently rearranged in advanced T-cell lymphomas 2 Hs.140720 [show with all ESTs]Unigene Representative Sequence: NM_0120831 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000371019(uc001knd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRAT2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRAT2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FRAT2 (NM_012083) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FRAT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRAT2 |
Additional cDNA sequence: AB045118.1 AF062739.1 BC020165.1 BT009770.1 1 DOTS entry: DT.309712 24/70 AceView cDNA sequences (see all 70): AI351188 NM_012083 BM853468 CD514830 BC020165 BE349056 BU173477 BU162649 AW627431 BU845891 AB045118 AW965899 BQ652802 BQ955169 BQ064683 BQ651734 BQ652164 CK430396 AA594265 AF062739 BQ652467 AI452478 BM839128 AW001094
GeneLoc Exon Structure
|
Expression
for FRAT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FRAT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCTCGGCC
About this image
See FRAT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FRAT2
SOURCE GeneReport for Unigene cluster: Hs.140720
SABiosciences Custom PCR Arrays for FRAT2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRAT2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FRAT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRAT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRAT2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRAT2 |
Orthologs
for FRAT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FRAT2 gene from 3/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Frat21 , 5 |
frequently rearranged in advanced T cell lymphomas more1, 5 |
79.94(n)1
76.62(a)1 |
|
19 (35.33 cM)5
2123981 NM_177603.31 NP_808271.11
418459785 |
African clawed frog
(Xenopus laevis) |
Amphibia |
AF062738.12 |
-- |
74.3(n) |
|
AF062738.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
gbp6 |
glycogen synthase kinase binding protein |
42(a) |
1 → many |
16(43620065-43621408) |
ENSEMBL Gene Tree for FRAT2 (if available)
TreeFam Gene Tree for FRAT2 (if available) |
Paralogs
for FRAT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FRAT2 gene
- FRAT12
1 SIMAP similar gene for FRAT2 using alignment to 1 protein entry: FRAT2_HUMAN:FRAT1
FRAT2 for paralogs About GeneDecksing
|
Genomic Variants
for FRAT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FRAT2 (99092254 - 99094458 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FRAT2
1 CNV: 4709
1 Indel: 71094 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRAT2 |
|
Disorders
/ Diseases
for FRAT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FRAT2 for disorders About GeneDecksing
OMIM gene information: 605006
OMIM disorders: --
2  diseases for FRAT2: About MalaCardsembryonal carcinoma carcinoma
Human Genome Epidemiology (HuGE) Navigator: FRAT2 (2 documents)
Export disorders for FRAT2 gene to outside databases
|
Publications
for FRAT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FRAT2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FRAT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. (PubMed id 11237732)1, 2, 3 Saitoh T....Katoh M. (2001)
- GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. (PubMed id 9635432)1, 2, 3 Yost C....Kimelman D. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. (PubMed id 15522877)1, 9 Stoothoff W.H....Johnson G.V. (2005)
- Association between polymorphisms in Wnt signaling pa thway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1 Lee D.Y....Kim J.G. (2010)
- Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. (PubMed id 17433504)1 Liu G.P....Wang J.Z. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. (PubMed id 12095675)1 Freemantle S.J....Dmitrovsky E. (2002)
- The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. (PubMed id 11738041)1 Bax B....Reith A.D. (2001)
|
External Searches for FRAT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FRAT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FRAT2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FRAT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FRAT2 gene:
Search GeneIP for patents involving FRAT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FRAT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FRAT2 | | OriGene shRNA RFP for FRAT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRAT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FRAT2 | | | OriGene Protein Over-expression Lysate for FRAT2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FRAT2 | | OriGene 3'-UTR Clone for FRAT2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FRAT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FRAT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FRAT2 | | OriGene Custom Protein Services for FRAT2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FRAT2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRAT2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRAT2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRAT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRAT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FRAT2 |
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| | | | Search Tocris compounds for FRAT2 |
| |  |  |  |  | | | | |
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 | | | FRAT2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRAT2 |
|  |  |  | | | | ThermoFisher Antibodies for FRAT2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FRAT2 |
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