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Aliases for FRAT2 Gene

Aliases for FRAT2 Gene

  • FRAT2, WNT Signaling Pathway Regulator 2 3
  • Frequently Rearranged In Advanced T-Cell Lymphomas 2 2 3 4 5
  • FRAT-2 3 4
  • GSK-3 Binding Protein FRAT2 2
  • GSK-3-Binding Protein FRAT2 3

External Ids for FRAT2 Gene

Previous GeneCards Identifiers for FRAT2 Gene

  • GC10M097985
  • GC10M098325
  • GC10M099223
  • GC10M098756
  • GC10M099082
  • GC10M092717

Summaries for FRAT2 Gene

Entrez Gene Summary for FRAT2 Gene

  • The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for FRAT2 Gene

FRAT2 (FRAT2, WNT Signaling Pathway Regulator) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Wnt Signaling Pathway and Pluripotency. An important paralog of this gene is FRAT1.

UniProtKB/Swiss-Prot for FRAT2 Gene

  • Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

Gene Wiki entry for FRAT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRAT2 Gene

Genomics for FRAT2 Gene

Regulatory Elements for FRAT2 Gene

Enhancers for FRAT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F097405 1.6 FANTOM5 Ensembl ENCODE 38.7 -72.7 -72679 4.0 HDGF ATF1 MLX ZFP64 ARID4B ZNF48 ZNF2 ZNF143 ZNF263 MXD4 FRAT2 RRP12 FRAT1 ARHGAP19 ZDHHC16 EXOSC1 MMS19 UBTD1 ENSG00000249967 HOGA1
GH10F097353 1.1 FANTOM5 Ensembl 7.9 -19.6 -19592 1.4 CTCF RRP12 ARHGAP19 PI4K2A SLIT1 SLIT1-AS1 ENSG00000249967 HOGA1 C10orf62 FRAT1 FRAT2
GH10F097412 1.2 FANTOM5 Ensembl ENCODE 1.4 -79.3 -79310 3.2 ELF3 TBP ATF1 CBX3 NFRKB RAD21 ZNF121 ELK1 GATA2 FOS RRP12 EXOSC1 ZDHHC16 MMS19 UBTD1 PGAM1 LCOR ZFYVE27 ARHGAP19 FRAT1
GH10F097336 0.5 Ensembl ENCODE 0.8 -2.7 -2700 2.5 PKNOX1 BMI1 ZIC2 ZFHX2 GATA3 CTBP1 GLIS2 ZBTB48 SCRT2 PRDM10 SLIT1 R3HCC1L NPM1P26 EXOSC1 RPL13AP5 LOXL4 MARVELD1 LCOR ENSG00000230928 PGAM1
GH10F097349 0.8 ENCODE 0.3 -15.6 -15628 1.1 OSR2 SCRT1 JUND SCRT2 RRP12 ARHGAP19 SLIT1 FRAT2 RPL34P20
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FRAT2 on UCSC Golden Path with GeneCards custom track

Promoters for FRAT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404668 909 4001 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF207 KLF13 ZNF263

Genomic Location for FRAT2 Gene

Chromosome:
10
Start:
97,332,497 bp from pter
End:
97,334,709 bp from pter
Size:
2,213 bases
Orientation:
Minus strand

Genomic View for FRAT2 Gene

Genes around FRAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRAT2 Gene

Proteins for FRAT2 Gene

  • Protein details for FRAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75474-FRAT2_HUMAN
    Recommended name:
    GSK-3-binding protein FRAT2
    Protein Accession:
    O75474
    Secondary Accessions:
    • Q5JTI0
    • Q8WUL9
    • Q9BYG2

    Protein attributes for FRAT2 Gene

    Size:
    233 amino acids
    Molecular mass:
    24051 Da
    Quaternary structure:
    • Binds GSK-3 and prevents GSK-3-dependent phosphorylation.

neXtProt entry for FRAT2 Gene

Post-translational modifications for FRAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRAT2 Gene

Domains & Families for FRAT2 Gene

Protein Domains for FRAT2 Gene

Suggested Antigen Peptide Sequences for FRAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75474

UniProtKB/Swiss-Prot:

FRAT2_HUMAN :
  • Belongs to the GSK-3-binding protein family.
Family:
  • Belongs to the GSK-3-binding protein family.
genes like me logo Genes that share domains with FRAT2: view

No data available for Gene Families for FRAT2 Gene

Function for FRAT2 Gene

Molecular function for FRAT2 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

Gene Ontology (GO) - Molecular Function for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FRAT2: view

Phenotypes for FRAT2 Gene

genes like me logo Genes that share phenotypes with FRAT2: view

Animal Models for FRAT2 Gene

MGI Knock Outs for FRAT2:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRAT2 Gene

Localization for FRAT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRAT2 Gene COMPARTMENTS Subcellular localization image for FRAT2 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FRAT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FRAT2 Gene

Pathways & Interactions for FRAT2 Gene

genes like me logo Genes that share pathways with FRAT2: view

Gene Ontology (GO) - Biological Process for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development NAS 9635432
GO:0008283 cell proliferation NAS 9635432
GO:0016055 Wnt signaling pathway IEA --
GO:1904886 beta-catenin destruction complex disassembly TAS --
genes like me logo Genes that share ontologies with FRAT2: view

No data available for SIGNOR curated interactions for FRAT2 Gene

Transcripts for FRAT2 Gene

mRNA/cDNA for FRAT2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRAT2 Gene

Frequently rearranged in advanced T-cell lymphomas 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRAT2 Gene

No ASD Table

Relevant External Links for FRAT2 Gene

GeneLoc Exon Structure for
FRAT2
ECgene alternative splicing isoforms for
FRAT2

Expression for FRAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FRAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRAT2 Gene

This gene is overexpressed in Whole Blood (x26.6).

Protein differential expression in normal tissues from HIPED for FRAT2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FRAT2 Gene



Protein tissue co-expression partners for FRAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FRAT2 Gene:

FRAT2

SOURCE GeneReport for Unigene cluster for FRAT2 Gene:

Hs.140720
genes like me logo Genes that share expression patterns with FRAT2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FRAT2 Gene

Orthologs for FRAT2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRAT2 34 35
  • 98.86 (n)
cow
(Bos Taurus)
Mammalia FRAT2 34 35
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Frat2 34 16 35
  • 79.94 (n)
rat
(Rattus norvegicus)
Mammalia Frat2 34
  • 78.41 (n)
Species where no ortholog for FRAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRAT2 Gene

ENSEMBL:
Gene Tree for FRAT2 (if available)
TreeFam:
Gene Tree for FRAT2 (if available)

Paralogs for FRAT2 Gene

Paralogs for FRAT2 Gene

(1) SIMAP similar genes for FRAT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FRAT2: view

Variants for FRAT2 Gene

Sequence variations from dbSNP and Humsavar for FRAT2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10882899 -- 97,336,188(+) ATCAA(C/G)TGCCT intron-variant, upstream-variant-2KB
rs111490180 -- 97,335,385(+) TTTGT(A/C)GAGAC upstream-variant-2KB
rs111558629 -- 97,333,393(+) TGGAA(-/TT)TCTTT utr-variant-3-prime
rs11189134 -- 97,332,409(+) CCCCC(C/G)GTTTA downstream-variant-500B
rs11189135 -- 97,335,515(+) ccggc(C/T)TAAGA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FRAT2 Gene

Variant ID Type Subtype PubMed ID
dgv169n67 CNV gain 20364138
esv29863 CNV loss 19812545
nsv1110852 OTHER inversion 24896259
nsv831952 CNV loss 17160897

Variation tolerance for FRAT2 Gene

Gene Damage Index Score: 5.38; 71.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FRAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRAT2 Gene

Disorders for FRAT2 Gene

Relevant External Links for FRAT2

Genetic Association Database (GAD)
FRAT2
Human Genome Epidemiology (HuGE) Navigator
FRAT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FRAT2

No disorders were found for FRAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRAT2 Gene

Publications for FRAT2 Gene

  1. Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. (PMID: 11237732) Saitoh T. … Katoh M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 64
  2. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. (PMID: 9635432) Yost C. … Kimelman D. (Cell 1998) 2 3 4 64
  3. Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. (PMID: 20613673) Lee D.Y. … Kim J.G. (Menopause 2010) 3 46 64
  4. FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. (PMID: 15522877) Stoothoff W.H. … Johnson G.V. (J. Biol. Chem. 2005) 3 22 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for FRAT2 Gene

Sources for FRAT2 Gene

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