Aliases for FRAT1 Gene
External Ids for FRAT1 Gene
Previous GeneCards Identifiers for FRAT1 Gene
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
GeneCards Summary for FRAT1 Gene
FRAT1 (Frequently Rearranged In Advanced T-Cell Lymphomas 1) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathway (WikiPathways) and Presenilin action in Notch and Wnt signaling. An important paralog of this gene is FRAT2.
UniProtKB/Swiss-Prot for FRAT1 Gene
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.