Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FRAT1 Gene

Aliases for FRAT1 Gene

  • Frequently Rearranged In Advanced T-Cell Lymphomas 1 2 3 4
  • FRAT-1 3 4
  • Frequently Rearranged In Advanced T-Cell Lymphomas 2
  • Proto-Oncogene FRAT1 3

External Ids for FRAT1 Gene

Summaries for FRAT1 Gene

Entrez Gene Summary for FRAT1 Gene

  • The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]

GeneCards Summary for FRAT1 Gene

FRAT1 (Frequently Rearranged In Advanced T-Cell Lymphomas 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Nanog in Mammalian ESC Pluripotency. An important paralog of this gene is FRAT2.

UniProtKB/Swiss-Prot for FRAT1 Gene

  • Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.

Gene Wiki entry for FRAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRAT1 Gene

Genomics for FRAT1 Gene

Genomic Location for FRAT1 Gene

Start:
97,319,265 bp from pter
End:
97,321,915 bp from pter
Size:
2,651 bases
Orientation:
Plus strand

Genomic View for FRAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRAT1 Gene

Proteins for FRAT1 Gene

  • Protein details for FRAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92837-FRAT1_HUMAN
    Recommended name:
    Proto-oncogene FRAT1
    Protein Accession:
    Q92837
    Secondary Accessions:
    • Q5JTI1
    • Q8NE74
    • Q8TDW9

    Protein attributes for FRAT1 Gene

    Size:
    279 amino acids
    Molecular mass:
    29093 Da
    Quaternary structure:
    • Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.

    Three dimensional structures from OCA and Proteopedia for FRAT1 Gene

neXtProt entry for FRAT1 Gene

Proteomics data for FRAT1 Gene at MOPED

Post-translational modifications for FRAT1 Gene

Other Protein References for FRAT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FRAT1 Gene

Domains for FRAT1 Gene

Protein Domains for FRAT1 Gene

Suggested Antigen Peptide Sequences for FRAT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92837

UniProtKB/Swiss-Prot:

FRAT1_HUMAN
Family:
  • Belongs to the GSK-3-binding protein family.:
    • Q92837
genes like me logo Genes that share domains with FRAT1: view

No data available for Gene Families for FRAT1 Gene

Function for FRAT1 Gene

Molecular function for FRAT1 Gene

UniProtKB/Swiss-Prot Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.

Phenotypes for FRAT1 Gene

MGI mutant phenotypes for FRAT1:
inferred from 1 alleles
GenomeRNAi human phenotypes for FRAT1:
genes like me logo Genes that share phenotypes with FRAT1: view

miRNA for FRAT1 Gene

miRTarBase miRNAs that target FRAT1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FRAT1 Gene

Localization for FRAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRAT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRAT1 Gene COMPARTMENTS Subcellular localization image for FRAT1 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for FRAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FRAT1: view

Pathways for FRAT1 Gene

genes like me logo Genes that share pathways with FRAT1: view

Gene Ontology (GO) - Biological Process for FRAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000578 embryonic axis specification IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0090263 positive regulation of canonical Wnt signaling pathway TAS --
genes like me logo Genes that share ontologies with FRAT1: view

Compounds for FRAT1 Gene

(1) Novoseek inferred chemical compound relationships for FRAT1 Gene

Compound -log(P) Hits PubMed IDs
glycogen 58.5 4
genes like me logo Genes that share compounds with FRAT1: view

Transcripts for FRAT1 Gene

mRNA/cDNA for FRAT1 Gene

Unigene Clusters for FRAT1 Gene

Frequently rearranged in advanced T-cell lymphomas:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FRAT1 Gene

No ASD Table

Relevant External Links for FRAT1 Gene

GeneLoc Exon Structure for
FRAT1
ECgene alternative splicing isoforms for
FRAT1

Expression for FRAT1 Gene

mRNA expression in normal human tissues for FRAT1 Gene

mRNA differential expression in normal tissues according to GTEx for FRAT1 Gene

This gene is overexpressed in Whole Blood (22.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FRAT1 Gene

SOURCE GeneReport for Unigene cluster for FRAT1 Gene Hs.126057

genes like me logo Genes that share expressions with FRAT1: view

No data available for mRNA Expression by UniProt/SwissProt for FRAT1 Gene

Orthologs for FRAT1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRAT1 35
  • 99.64 (n)
  • 98.92 (a)
FRAT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FRAT1 35
  • 86.47 (n)
  • 85.24 (a)
FRAT1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRAT1 35
  • 85.42 (n)
  • 80.15 (a)
mouse
(Mus musculus)
Mammalia Frat1 35
  • 82.35 (n)
  • 78.68 (a)
Frat1 16
Peg12 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Peg12 35
  • 78.92 (n)
  • 73.12 (a)
Species with no ortholog for FRAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRAT1 Gene

ENSEMBL:
Gene Tree for FRAT1 (if available)
TreeFam:
Gene Tree for FRAT1 (if available)

Paralogs for FRAT1 Gene

Paralogs for FRAT1 Gene

Selected SIMAP similar genes for FRAT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FRAT1: view

Variants for FRAT1 Gene

Sequence variations from dbSNP and Humsavar for FRAT1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1334891 -- 97,321,114(+) GCCAG(G/T)TTCTG utr-variant-3-prime
rs1334892 -- 97,321,224(+) GGGCG(G/T)CTGTG utr-variant-3-prime
rs1932002 -- 97,317,922(+) AACAG(C/G)TATTT upstream-variant-2KB
rs3740512 -- 97,318,988(+) GTGTG(C/T)GTGCT upstream-variant-2KB
rs3740513 -- 97,319,174(+) AGCGC(C/G)GTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FRAT1 Gene

Variant ID Type Subtype PubMed ID
nsv831952 CNV Loss 17160897
nsv895914 CNV Gain 21882294
dgv169n67 CNV Gain 20364138

Relevant External Links for FRAT1 Gene

HapMap Linkage Disequilibrium report
FRAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRAT1 Gene

Disorders for FRAT1 Gene

(3) Novoseek inferred disease relationships for FRAT1 Gene

Disease -log(P) Hits PubMed IDs
lymphoma t-cell 59.8 3
leukemia 18 1
tumors 0 5

Relevant External Links for FRAT1

Genetic Association Database (GAD)
FRAT1
Human Genome Epidemiology (HuGE) Navigator
FRAT1
genes like me logo Genes that share disorders with FRAT1: view

No data available for UniProtKB/Swiss-Prot for FRAT1 Gene

Publications for FRAT1 Gene

  1. Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. (PMID: 9034327) Jonkers J. … Berns A. (EMBO J. 1997) 2 3 4 23
  2. Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. (PMID: 11894125) Saitoh T. … Katoh M. (Int. J. Oncol. 2002) 3 4 23
  3. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. (PMID: 12556519) Hino S. … Kikuchi A. (J. Biol. Chem. 2003) 3 4 23
  4. Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. (PMID: 16479254) Wang Y. … Xu N. (Br. J. Cancer 2006) 3 23
  5. FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. (PMID: 16982607) Hagen T. … Reith A.D. (J. Biol. Chem. 2006) 3 23

Products for FRAT1 Gene

Sources for FRAT1 Gene

Back to Top

Content