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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FRAS1 Gene

protein-coding   GIFtS: 55
GCID: GC04P078978

Fraser syndrome 1
 Explore 4 diseases affiliated with
FRAS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FRAS1    

Aliases
for FRAS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fraser Syndrome 11 2
KIAA15001 3
FLJ149271
FLJ220311
Extracellular Matrix Protein FRAS12

External Ids:    HGNC: 191851   Entrez Gene: 801442   Ensembl: ENSG000001387597   OMIM: 6078305   UniProtKB: Q86XX43   

Export aliases for FRAS1 gene to outside databases

Previous GC identifers: GC00U900628 GC04P079732 GC04P079437 GC04P079336 GC04P079198 GC04P074729


Summaries
for FRAS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FRAS1:
This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement
membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem
malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Oct 2009)

Gene Wiki entry for FRAS1


Genomic Views
for FRAS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FRAS1 gene promoter:
         Pbx1a   MyoD   LUN-1   NF-kappaB   SREBP-1b   Evi-1   C/EBPalpha   HFH-1   c-Myb   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FRAS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FRAS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FRAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21.21

FRAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FRAS1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P078978:  view genomic region     (about GC identifiers)

Start:
 78,978,724 bp from pter      End:
 79,465,423 bp from pter
Size:
 486,700 bases      Orientation:
 plus strand

Proteins
for FRAS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FRAS1_HUMAN, Q86XX4 (See protein sequence)
Recommended Name: Extracellular matrix protein FRAS1 precursor  
Size: 4008 amino acids; 443214 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential)
Sequence caution: Sequence=BAB15216.1; Type=Frameshift; Positions=1858, 1951;
Secondary accessions: A2RRR8 Q86UZ4 Q8N3U9 Q8NAU7 Q96JW7 Q9H6N9 Q9P228
Alternative splicing: 5 isoforms:  Q86XX4-1   Q86XX4-2   Q86XX4-4   Q86XX4-5   Q86XX4-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FRAS1: NX_Q86XX4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86XX4

    • FRAS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159605.1  NP_079350.5  

    ENSEMBL proteins: 
     ENSP00000326330   ENSP00000425583   ENSP00000423645   ENSP00000423809   ENSP00000422221  
     ENSP00000422834   ENSP00000264895   ENSP00000264899  

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    Uscn Proteins for FRAS1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane ----
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0031012colocalizes with extracellular matrix ISS--


    FRAS1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FRAS1

    Protein Domains /
    Families
    for FRAS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FRAS1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR006212 Furin_repeat
     IPR000742 EG-like_dom
     IPR003644 Calx_beta
     IPR009030 Growth_fac_rcpt
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry Q86XX4

    ProtoNet protein and cluster: Q86XX4

    2 Blocks protein families:
    IPB001007 von Willebrand factor
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: FRAS1_HUMAN, Q86XX4
    Domain: The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding (By
    similarity)
    Similarity: Belongs to the FRAS1 family
    Similarity: Contains 5 Calx-beta domains
    Similarity: Contains 12 CSPG (NG2) repeats
    Similarity: Contains 14 FU (furin-like) repeats
    Similarity: Contains 6 VWFC domains


    Function
    for FRAS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): FRAS1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FRAS1
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate FRAS1 (see all 83):
    hsa-miR-520f hsa-miR-605 hsa-miR-138-2* hsa-miR-622 hsa-miR-1 hsa-miR-548b-3p hsa-let-7i hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmid: FRAS1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRAS1 (see all 4)
    OriGene shRNA RFP: FRAS1
    OriGene siRNA: FRAS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRAS1

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for FRAS1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRAS1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--


    FRAS1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FRAS1:
     Decreased number of cells in m  Increased gamma-H2AX phosphory 

    Animal Models:
         10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fras1):
     cardiovascular system  cellular  integument  limbs/digits/tail  mortality/aging 
     no phenotypic analysis  other  renal/urinary system  respiratory system  vision/eye 

    FRAS1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FRAS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    		Inhibition of Angiogenesis by TSP10.37
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3PTEN Pathway
    		PTEN Pathway1.00
    		Phospholipase-C Pathway0.56

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FRAS1 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FRAS1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for FRAS1 (Q86XX42, 3 ENSP000002648954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIP1Q9Y3R03, ENSP000003810984I2D: score=1 STRING: ENSP00000381098
    TP53ENSP000002693054STRING: ENSP00000269305
    --P310162MINT-8108168
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002009morphogenesis of an epithelium ----
    GO:0007154cell communication IEA--
    GO:0015031protein transport ----
    GO:0043588skin development ----


    FRAS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FRAS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FRAS1

    1 HMDB Compound for FRAS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about FRAS1 

    Transcripts
    for FRAS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FRAS1 gene (5 alternative transcripts): 
    NM_001166133.1  NM_025074.6  NM_020875.1  NM_032863.2  NM_206841.1  

    Unigene Cluster for FRAS1:

    Fraser syndrome 1
    Hs.369448  [show with all ESTs]
    Unigene Representative Sequence: NM_025074
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325942(uc003hkw.3 uc010ijj.2) ENST00000508909 ENST00000502446(uc003hky.1 uc003hla.1)
    ENST00000508900(uc003hkz.3) ENST00000510944 ENST00000512123(uc003hlc.1)
    ENST00000509802 ENST00000264895(uc003hlb.2) ENST00000264899

    miRNA
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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate FRAS1 (see all 83):
    hsa-miR-520f hsa-miR-605 hsa-miR-138-2* hsa-miR-622 hsa-miR-1 hsa-miR-548b-3p hsa-let-7i hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmid: FRAS1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FRAS1 (see all 4)
    OriGene shRNA RFP: FRAS1
    OriGene siRNA: FRAS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FRAS1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FRAS1 (NM_001166133)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FRAS1

    Additional cDNA sequence: 

    AB040933.2 AK025684.1 AK027833.1 AK092082.1 AK096838.1 AL157471.1 AL831853.1 AL833581.1 
    BC009254.2 BC020192.1 BC052281.1 BC064487.1 BC094853.1 BC131820.1 BC131821.1 BX647420.1 
    BX647949.1 CR627393.1 

    13 DOTS entries:

    DT.112660  DT.91961424  DT.100644453  DT.100674041  DT.100772961  DT.40252449  DT.91797323  DT.121263327 
    DT.121263333  DT.40236031  DT.101968750  DT.109827  DT.40308854 

    24/126 AceView cDNA sequences (see all 126):

    R46219 BX641547 AK092082 BC064487 AA359899 AL157471 CB241455 BE379237 
    AW138974 BF476189 AB040933 CF891527 BF431523 NM_206841 AL831853 AA308673 
    BX647420 NM_025074 AA626318 BC052281 AX747347 AA367418 BE745426 AA745882 

    GeneLoc Exon Structure


    Expression
    for FRAS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FRAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTACTGCTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FRAS1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FRAS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FRAS1

    SOURCE GeneReport for Unigene cluster: Hs.369448

    UniProtKB/Swiss-Prot: FRAS1_HUMAN, Q86XX4
    Tissue specificity: Expressed in many adult tissues, with highest levels in kidney, pancreas and thalamus. Relatively
    high expression was also detected in fetal kidney and heart

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FRAS1

    Orthologs
    for FRAS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FRAS1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FRAS11 Fraser syndrome 1 71.49(n)
    70.33(a)    		   422506  XM_420470.3  XP_420470.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 86(a)
    		 1 ↔ 1
    		 5(145562802-145588442)
    zebrafish
    (Danio rerio)    		 Actinopterygii fras11 Fraser syndrome 1 64.54(n)
    62.62(a)    		   563428  NM_001130840.1  NP_001124312.1 


    ENSEMBL Gene Tree for FRAS1 (if available)
    TreeFam Gene Tree for FRAS1 (if available) 

    Paralogs
    for FRAS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FRAS1 gene
    FREM22  CSPG42  FREM12  FREM32  
    3 SIMAP similar genes for FRAS1 using alignment to 12 protein entries:     FRAS1_HUMAN (see all proteins):
    DKFZp761P1423    PCSK6    FREM2

    FRAS1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FRAS1
    PGOHUM00000258261


    Genomic Variants
    for FRAS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 20 variations for FRAS1
         15/16 CNVs (see all 16): 43600 63870 44170 62213 4401 6282 22652 36303 68753 98761 39377 23114 51462 9484 68752
         4 Indels: 60479 98762 68751 68754
    Human Gene Mutation Database (HGMD): FRAS1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FRAS1
    DNA2.0 Custom Variant and Variant Library Synthesis for FRAS1

    Disorders / Diseases
    for FRAS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FRAS1 for disorders           About GeneDecksing

    OMIM gene information: 607830   
    OMIM disorders: 219000  
    UniProtKB/Swiss-Prot: FRAS1_HUMAN, Q86XX4
  • Defects in FRAS1 are a cause of Fraser syndrome (FRASS) [MIM:219000]. Fraser syndrome is a multisystem
    • malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and
    congenital heart defects

    4 diseases for FRAS1:    About MalaCards
    fraser syndrome    cryptophthalmos    renal agenesis    syndactyly

    2 diseases from the University of Copenhagen DISEASES database for FRAS1:
    Renal agenesis     Syndactyly
    Human Genome Epidemiology (HuGE) Navigator: FRAS1 (2 documents)

    Export disorders for FRAS1 gene to outside databases

    Publications
    for FRAS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FRAS1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with FRAS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein. (PubMed id 12766769)1, 2, 3, 9 McGregor L.K.... Scambler P.J. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    5. The clinical spectrum of the Fraser syndrome: report of three new cases and review. (PubMed id 3118036)1, 3 Gattuso J....Baraitser M. (1987)
    6. Identification of two novel CAKUT-causing genes by mas sively parallel exon resequencing of candidate genes in patients with unilateral renal agenesis. (PubMed id 21900877)1 Saisawat P....Hildebrandt F. (2012)
    7. Clinical and molecular studies in two families with F raser syndrome: a new FRAS1 gene mutation, prenatal ultrasound findings and imp lications for genetic counselling. (PubMed id 22029163)1 Ogur G....Malatyalioglu E. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)

    External Searches for FRAS1 gene

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    Genome Databases showing FRAS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80144 HGNC: 19185 AceView: FRAS1 Ensembl:ENSG00000138759 euGenes: HUgn80144
    ECgene: FRAS1 H-InvDB: FRAS1

    Other Databases showing FRAS1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1500

    Specialized Databases showing FRAS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FRAS1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FRAS1

    Intellectual Property
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