V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

MTOR Gene

protein-coding GIFtS: 53

GC01M011089

mechanistic target of rapamycin (serine/threonine kinase)
(Previous name: FK506 binding protein 12-rapamycin associated protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FRAP, FRAP2, FRAP1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ44809 ^¹, ²
FRAP ^², ³
FRAP1 ^²
FRAP2 ^², ³
OTTHUMP00000001983 ^²
RAFT1 ^¹, ²
RAPT1 ^¹, ², ³
mTOR ^³

Descriptions
FK506 binding protein 12-rapamycin associated protein 1 ^¹, ²
FK506 binding protein 12-rapamycin associated protein 2 ^²
FK506-binding protein 12-rapamycin complex-associated protein 1 ^³
FKBP-rapamycin associated protein ^²
FKBP12-rapamycin complex-associated protein 1 ^²
Mammalian target of rapamycin ^³
Rapamycin target protein ^², ³
mechanistic target of rapamycin (serine/threonine kinase) ^¹
rapamycin and FKBP12 target 1 ^²
rapamycin associated protein FRAP2 ^²

External Ids
HGNC: 3942¹
Entrez Gene: 2475²
UniProtKB: P42345³
Ensembl: ENSG00000198793⁷

Search outside databases for aliases for MTOR gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MTOR:

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related

kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient

deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive

effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: FRAP_HUMAN, P42345

Function: Acts as the target for the cell-cycle arrest and immunosuppressive effects of the

FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473

phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton

organization

Gene Wiki entry for MTOR (Mammalian_target_of_rapamycin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36

MTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M011089: (about GC identifiers)

Start:	11,089,179 bp from pter
End:	11,245,176 bp from pter
Size:	155,998 bases
Orientation:	minus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FRAP_HUMAN, P42345 (See protein sequence)

Recommended Name: FKBP12-rapamycin complex-associated protein

Size: 2549 amino acids; 288892 Da

Subunit: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian

target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does

not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the

TORC2 complex

Sequence caution: Sequence=AAC39933.1; Type=Frameshift; Positions=956, 999;

PDB structures from and Proteopedia :

1AUE (3D)

1FAP (3D)

1NSG (3D)

2FAP (3D)

2GAQ (3D)

2NPU (3D)

3FAP (3D)

4FAP (3D)

Secondary accessions: Q5TER1 Q6LE87 Q96QG3 Q9Y4I3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004949.1

ENSEMBL proteins:

ENSP00000366034 ENSP00000354558

Human Recombinant Proteins

	Invitrogen human recombinant proteins for MTOR
	Millipore Purified and/or Recombinant MTOR Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (mTOR)
	Human Recombinant Proteins from Abnova (FRAP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11853878
GO:0005829	cytosol	EXP	15718470 15755954 15809305
GO:0005942	phosphoinositide 3-kinase complex	NAS	15539461
GO:0016020	membrane	IDA	11853878

About this table

Antibodies for MTOR:

	Invitrogen Antibodies for MTOR
	Millipore Mono- and Polyclonal Antibodies for the study of MTOR
	Sigma-Aldrich Antibody Arrays and Antibodies for MTOR
	R&D Systems Antibodies for MTOR (TOR)
	Cell Signaling Technology (CST) Antibodies for MTOR
	Antibodies from Abcam (mTOR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FRAP1)
	Novus Biologicals Antibodies for FRAP1

Assays for MTOR:

	Invitrogen Assays for MTOR
	Millipore Kits and Assays for the Analysis of MTOR
	R&D Systems ELISAs for MTOR (TOR) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P42345

ProtoNet protein and cluster: P42345

3 Blocks protein families:

IPB000357 HEAT repeat

IPB000403 Phosphatidylinositol 3- and 4-kinase

IPB003151 PIK-related kinase

UniProtKB/Swiss-Prot: FRAP_HUMAN, P42345

Similarity: Belongs to the PI3/PI4-kinase family

Similarity: Contains 1 FAT domain

Similarity: Contains 1 FATC domain

Similarity: Contains 7 HEAT repeats

Similarity: Contains 1 PI3K/PI4K domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MTOR)
		Millipore RNAi Products for the Analysis of MTOR Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FRAP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004958

Applied Biosystems Silencer® siRNAs for MTOR

Sigma-Aldrich siRNA and siRNA Panels for MTOR

Sigma-Aldrich shRNA Panels and shRNA for MTOR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004958
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004958
untagged cDNA clone in CMV expression vector: NM_004958

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004958

UniProtKB/Swiss-Prot: FRAP_HUMAN, P42345

Function: Acts as the target for the cell-cycle arrest and immunosuppressive effects of the

FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473

phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton

organization

6 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mtor):

embryogenesis	growth/size	lethality-prenatal/perinatal	nervous system	no phenotypic analysis
normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	protein serine/threonine kinase activity	EXP	15718470
GO:0016301	kinase activity	TAS	11853878
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	--
GO:0051219	phosphoprotein binding	IPI	11853878

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/17 Sigma-Aldrich "Your Favorite Gene" Pathways for MTOR (Your Favorite Gene powered by Ingenuity) (see all 17 )

B Cell Receptor Signaling
Glioma Signaling
PI3K/AKT Signaling
Cardiac Hypertrophy Signaling
Acute Myeloid Leukemia Signaling

GeneDecks MTOR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MTOR

5/12 Interacting proteins for MTOR (P42345^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 12 )
Interactant Interaction Details
GeneCard External ID(s)
RICTOR Q6R327¹^,² EBI-359260, EBI-1387196 MINT-6948596 MINT-6948610 EBI-359260, EBI-1387196 MINT-6948596 MINT-6948610
FKBP1A P62942¹ EBI-359260, EBI-1027571
PREX1 Q8TCU6¹ EBI-359260, EBI-1046542
RICTOR Q6R327¹^,² EBI-359260, EBI-1387196 MINT-6948596 MINT-6948610 EBI-359260, EBI-1387196 MINT-6948596 MINT-6948610
MAPKAP1 Q9BPZ7² MINT-6948596 MINT-6948610
About this table
5 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 15539461
GO:0007584 response to nutrient NAS 15539461
GO:0016049 cell growth TAS 11853878
GO:0016310 phosphorylation IDA 11853878
GO:0030163 protein catabolic process TAS 11853878
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MTOR
10/25 Novoseek chemical compound relationships for MTOR gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ap 23573	80.53	4	16205124 (1), 19012509 (1), 17720651 (1)
temsirolimus	75.78	9	17987219 (2), 15955899 (1), 17092282 (1), 15563243 (1) (see all 7)
phosphatidylinositol	68.32	30	10749120 (1), 16099944 (1), 9891068 (1), 15563472 (1) (see all 23)
lonafarnib	63.34	8	18316583 (3), 16006564 (2)
wortmannin	62.77	18	9249059 (2), 12569580 (1), 15227545 (1), 16372478 (1) (see all 13)
phosphoinositide	55.40	16	17656362 (2), 12374276 (2), 19061482 (1), 18025271 (1) (see all 12)
pd 98,059	50.16	4	10623881 (1), 9182578 (1), 17707924 (1)
threonine	50.08	17	18786649 (1), 19379082 (1), 17565979 (1), 16953237 (1) (see all 13)
tyrosine	46.04	19	10623881 (2), 16452206 (2), 10749120 (1), 17109620 (1) (see all 16)
sp 600125	43.00	4	19059405 (2), 16099428 (1), 18377285 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MTOR)
		Millipore RNAi Products for the Analysis of MTOR Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FRAP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004958

Sigma-Aldrich siRNA and siRNA Panels for MTOR

Sigma-Aldrich shRNA Panels and shRNA for MTOR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004958

REFSEQ mRNAs for MTOR gene:

NM_004958.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004958

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004958
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004958
                                 untagged cDNA clone in CMV expression vector: NM_004958

24/260 AceView cDNA sequences (see all 260 ):

AA975907 AA557157 CB115236 AA814913 L35478 AI361120 BM825377 CA432283

BQ440695 BM717612 BI857699 BU629108 AI803273 AI383232 AI633584 BU630556

BU741628 AI025628 AA633164 AK126762 AI479698 AL079589 BI771714 AI797430

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MTOR

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	·	15c	^	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22
SP1:																													-		-						-
SP2:																																					-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MTOR

2 Ensembl transcripts including schematic representations:

ENST00000376838 ENST00000361445

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MTOR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MTOR

¹ / ²

6 probe-sets matching MTOR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40139_at²	U95-A	1	1.00	1.00	0.90	1.04	--	--	--	--	--
267_at²	U95-A	1	1.00	1.00	0.87	0.96	--	--	--	--	--
202288_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
215381_at*²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
202288_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215381_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: FRAP_HUMAN, P42345
Tissue specificity: Expressed in numerous tissues, with highest levels in testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MTOR gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FRAP1¹	--	FK506 binding protein 12-rapamycin associated protein more	92.18(n) 99.45(a)	478232 XM_535407.2 XP_535407.2
rat (Rattus norvegicus)	Frap1¹	--	FK506 binding protein 12-rapamycin associated protein more	90.94(n) 98.9(a)	56718 NM_019906.1 NP_063971.1
mouse (Mus musculus)	Mtor⁵ Frap1¹	4 (71.00 cM)⁵	mechanistic target of rapamycin (serine/threonine kinase)⁵ FK506 binding protein 12-rapamycin associated protein more¹	90.4(n)¹ 98.9(a)¹	56717¹ NM_020009.1¹ NP_064393.1¹ AF152838⁵ AI327068⁵ (see all 18)
chicken (Gallus gallus)	FRAP1¹	--	FK506 binding protein 12-rapamycin associated protein more	82.32(n) 97.3(a)	419455 XM_417614.2 XP_417614.2
zebrafish (Danio rerio)	wufc22h08²	--	wufc22h08	81.32(n)	324254 AI658150.1

About this table Species with no ortholog for MTOR

ENSEMBL Gene Tree for MTOR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MTOR gene

ENSG00000205536² ENSG00000180747² ENSG00000205685² ENSG00000205535² SLC7A5P1² ENSG00000205152² ENSG00000157341² LOC595101²

ENSG00000205534² ENSG00000205691² SMG1² PRKDC² ENSG00000185710²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/694 NCBI SNPs in MTOR are shown (see all 694 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 265)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2536^1,2	A,C,F,H	11089300(+)	`TAATTT/CCCAAT`	1	--	ut3¹		9		MN NA EU EA WA	906
	rs2295080^1,2	A,C,F,H	11245215(+)	`TCCCAT/GCCCTG`	1	--	ng3¹		5		EA MN EU	2140
	rs2295079^1,2	A,C,F	11245152(-)	`GGGCAC/GGGGGC`	1	--	ut5¹ ese³		2		EA	1658
	rs12139042^1,2	C,F,H	11089733(+)	`TGGCTG/ATGCTG`	1	--	ut3¹		6		NA EU EA	420
--	rs7542591^1,2	A,C	11246488(+)	`gaggcC/Ggaggc`	1	--	ng3¹		0	--	--	--	--
--	rs4845860^1,2	C	11246780(+)	`AATACA/GTAGCC`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs17027474^1,2	F	11245207(-)	`GGAACC/TCTCCT`	1	--	ng3¹ trp³		2		MN EA	356
	rs28730685^1,2	C	11195116(-)	`TAGGGC/TAGCGC`	1	A/V	mis¹		4		EU EA WA	420
	rs1057079^1,2	A,C,F,H,O	11127645(-)	`ACTGCA/GATGGC`	1	A/A	syn¹		22		EA NA EU WA	3500
	rs2275527^1,2	A,C,F,H,O	11113233(-)	`GAGAGC/TGAGGC`	1	S/S	syn¹		15		EA NS MN NA EU WA	2168

About this table

HapMap Linkage Disequilibrium images for MTOR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601231

10/51 Novoseek disease relationships for MTOR gene (see all 51 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tuberous sclerosis	80.10	18	18695678 (3), 19143643 (3), 14614311 (1), 16545079 (1) (see all 14)
cancer	57.12	88	19166931 (5), 17041628 (4), 16404421 (4), 17720651 (4) (see all 43)
tumors	56.17	114	18511708 (5), 14634209 (4), 16452206 (4), 15937108 (4) (see all 59)
renal cancer	52.83	1	19165638 (1)
carcinoma renal cell	51.78	8	19379082 (2), 18279068 (2), 17162089 (1), 17987219 (1) (see all 5)
lymphangioleiomyomatosis	51.50	1	19143643 (1)
angiomyolipoma	46.92	4	18085521 (1), 17521703 (1), 16575396 (1), 19265534 (1)
breast cancer	41.36	24	15501954 (4), 16648488 (2), 17010069 (2), 16288304 (2) (see all 14)
astrocytoma subependymal giant cell	39.27	1	15624760 (1)
glioma	36.73	20	18759130 (3), 17804702 (3), 15800333 (1), 19177002 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/697 PubMed articles for MTOR gene (see all 697 ):

A mammalian protein targeted by G1-arresting rapamycin-receptor complex. (PubMed id 8008069)^{1, 2, 3, 4} Brown E.J.... Schreiber S.L. (1994)
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. (PubMed id 8662507)^{1, 3, 4} Choi J.... Clardy J. (1996)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)^{1, 3, 4} Sarbassov D.D.... Sabatini D.M. (2005)
Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. (PubMed id 10089303)^{1, 3, 4} Liang J.... Clardy J. (1999)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Rictor, a novel binding partner of mTOR, defines a rapamycin- insensitive and raptor-independent pathway that regulates the cytoskeleton. (PubMed id 15268862)^{3, 4} Sarbassov D.D.... Sabatini D.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of ubiquilin 1, an mTOR-interacting protein. (PubMed id 11853878)^{3, 4} Wu S.... Avruch J. (2002)
The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. (PubMed id 11426320)^{3, 4} Stover C.... Schwaeble W. (2001)
Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PubMed id 9653645)^{3, 4} Onyango P.... Weith A. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2475	HGNC: 3942	AceView: FRAP1	Ensembl:ENSG00000198793	euGenes: HUgn2475
ECgene: MTOR	H-InvDB: MTOR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MTOR	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MTOR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MTOR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MTOR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MTOR		Antibodies for MTOR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MTOR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FRAP1)
	Antibodies (FRAP1)
	Chimera RNAi (FRAP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for MTOR

	Recombinant Proteins (mTOR)
	Antibodies (mTOR)

Search OriGene for MTOR

Search Tocris compounds for MTOR

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FRAP1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MTOR Gene at Home site.
Version 2.41.1
server5.xennexinc.com

MTOR Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for MTOR

Summaries
for MTOR

Genomic Location
for MTOR

Proteins
for MTOR

Protein Domains/
Families
for MTOR

Gene Function
for MTOR

Pathways & Interactions
for MTOR

Drugs & Compounds
for MTOR

Transcripts
for MTOR

Expression
for MTOR

Orthologs
for MTOR

Paralogs
for MTOR

SNPs/Variants
for MTOR

Disorders & Mutations
for MTOR

Medical News
for MTOR

Publications
for MTOR

Search for MTOR

Genome Databases showing MTOR

Other Databases showing MTOR

Specialized Databases showing MTOR

Licensable Technologies
for MTOR

Services
for MTOR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MTOR Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor MTOR

Summariesfor MTOR

Genomic Locationfor MTOR

Proteinsfor MTOR

Protein Domains/Familiesfor MTOR

Gene Functionfor MTOR

Pathways & Interactionsfor MTOR

Drugs & Compoundsfor MTOR

Transcriptsfor MTOR

Expression for MTOR

Orthologsfor MTOR

Paralogsfor MTOR

SNPs/Variantsfor MTOR

Disorders & Mutationsfor MTOR

Medical Newsfor MTOR

Publicationsfor MTOR

Search for MTOR

Genome Databases showing MTOR

Other Databases showing MTOR

Specialized Databases showing MTOR

Licensable Technologiesfor MTOR

Servicesfor MTOR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MTOR

Summaries
for MTOR

Genomic Location
for MTOR

Proteins
for MTOR

Protein Domains/
Families
for MTOR

Gene Function
for MTOR

Pathways & Interactions
for MTOR

Drugs & Compounds
for MTOR

Transcripts
for MTOR

Expression
for MTOR

Orthologs
for MTOR

Paralogs
for MTOR

SNPs/Variants
for MTOR

Disorders & Mutations
for MTOR

Medical News
for MTOR

Publications
for MTOR

Licensable Technologies
for MTOR

Services
for MTOR