FRA12A is a folate-sensitive chromosomal fragile site prone to breakage. No consistent phenotype has been observed with FRA12A, and it can be inherited without phenotypic effect (Berg et al., 2000 [PubMed 10955484]). However, mental retardation with or without other anomalies has been described in patients with over 40% of cells expressing FRA12A (Winnepenninckx et al., 2007).[supplied by OMIM, Mar 2008]
GeneCards Summary for FRA12A Gene
FRA12A (Fragile Site, Folic Acid Type, Rare, Fra(12)(Q13.1)) is an Uncategorized gene.