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Aliases for FRA10AC1 Gene

Aliases for FRA10AC1 Gene

  • Fragile Site, Folic Acid Type, Rare, Fra(10)(Q23.3) Or Fra(10)(Q24.2) Candidate 1 2 3
  • C10orf4 3 4 6
  • FRA10A 3 6
  • Rare Folic Acid-Type Fragile Site, FRA(10)(Q23.3), Candidate Gene 1 3
  • Chromosome 10 Open Reading Frame 4 2
  • Fragile Site 10q23.3 3
  • Protein FRA10AC1 3
  • F26C11.1-Like 3

External Ids for FRA10AC1 Gene

Previous HGNC Symbols for FRA10AC1 Gene

  • C10orf4

Previous GeneCards Identifiers for FRA10AC1 Gene

  • GC10M095427
  • GC10M089055

Summaries for FRA10AC1 Gene

Entrez Gene Summary for FRA10AC1 Gene

  • The protein encoded by this gene is a nuclear phosphoprotein of unknown function. The 5' UTR of this gene is part of a CpG island and contains a tandem CGG repeat region that normally consists of 8-14 repeats but can expand to over 200 repeats. The expanded allele becomes hypermethylated and is not transcribed; however, an expanded repeat region has not been associated with any disease phenotype. This gene is found within the rare FRA10A folate-sensitive fragile site. [provided by RefSeq, Mar 2010]

GeneCards Summary for FRA10AC1 Gene

FRA10AC1 (Fragile Site, Folic Acid Type, Rare, Fra(10)(Q23.3) Or Fra(10)(Q24.2) Candidate 1) is a Protein Coding gene.

Gene Wiki entry for FRA10AC1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRA10AC1 Gene

Genomics for FRA10AC1 Gene

Genomic Location for FRA10AC1 Gene

Start:
93,667,883 bp from pter
End:
93,702,572 bp from pter
Size:
34,690 bases
Orientation:
Minus strand

Genomic View for FRA10AC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FRA10AC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRA10AC1 Gene

No data available for Regulatory Elements for FRA10AC1 Gene

Proteins for FRA10AC1 Gene

  • Protein details for FRA10AC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70Z53-F10C1_HUMAN
    Recommended name:
    Protein FRA10AC1
    Protein Accession:
    Q70Z53
    Secondary Accessions:
    • C9JCR4
    • C9JCR5
    • C9JMY4
    • Q70Z49
    • Q70Z50
    • Q70Z51
    • Q70Z52
    • Q8N293
    • Q8WVH5
    • Q96JQ8

    Protein attributes for FRA10AC1 Gene

    Size:
    315 amino acids
    Molecular mass:
    37548 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Expansion of a polymorphic CGG repeat within the 5-UTR of this gene FRA10AC1 may be the cause of folate-sensitive fragile site FRA10A expression which is characterized by chromosomal breakage under specific cell culture conditions. No distinct phenotype has been associated with expression of FRA10A. Nevertheless, some studies have proposed that this fragile site expression might be associated with mental retardation, tumorigenesis, or neurological disorders. However, these associations can be attributed to ascertainment bias
    SequenceCaution:
    • Sequence=AAK55529.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for FRA10AC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRA10AC1 Gene

Proteomics data for FRA10AC1 Gene at MOPED

Post-translational modifications for FRA10AC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRA10AC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRA10AC1 Gene

Domains for FRA10AC1 Gene

Protein Domains for FRA10AC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRA10AC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FRA10AC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FRA10AC1 Gene

Function for FRA10AC1 Gene

Gene Ontology (GO) - Molecular Function for FRA10AC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with FRA10AC1: view

Animal Model Products

CRISPR Products

miRNA for FRA10AC1 Gene

miRTarBase miRNAs that target FRA10AC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FRA10AC1 Gene

Localization for FRA10AC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRA10AC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FRA10AC1 Gene COMPARTMENTS Subcellular localization image for FRA10AC1 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FRA10AC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FRA10AC1: view

Pathways for FRA10AC1 Gene

SuperPathways for FRA10AC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRA10AC1 Gene

None

No data available for Pathways by source for FRA10AC1 Gene

Transcripts for FRA10AC1 Gene

Unigene Clusters for FRA10AC1 Gene

Fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FRA10AC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FRA10AC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRA10AC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: -
SP2: - -
SP3: - - - - -
SP4: -
SP5: -
SP6: - -
SP7:
SP8:

Relevant External Links for FRA10AC1 Gene

GeneLoc Exon Structure for
FRA10AC1
ECgene alternative splicing isoforms for
FRA10AC1

Expression for FRA10AC1 Gene

mRNA expression in normal human tissues for FRA10AC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FRA10AC1 Gene

SOURCE GeneReport for Unigene cluster for FRA10AC1 Gene Hs.586650

mRNA Expression by UniProt/SwissProt for FRA10AC1 Gene

Q70Z53-F10C1_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in brain, heart, skeletal muscle, kidney and liver.
genes like me logo Genes that share expressions with FRA10AC1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FRA10AC1 Gene

Orthologs for FRA10AC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FRA10AC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRA10AC1 35
  • 99.68 (n)
  • 99.68 (a)
FRA10AC1 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C26H10ORF4 36
  • 92 (a)
OneToOne
FRA10AC1 35
  • 92.91 (n)
  • 92.06 (a)
dog
(Canis familiaris)
Mammalia FRA10AC1 35
  • 93.08 (n)
  • 92.65 (a)
FRA10AC1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fra10ac1 35
  • 86.35 (n)
  • 86.67 (a)
Fra10ac1 16
Fra10ac1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FRA10AC1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FRA10AC1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fra10ac1 35
  • 88.04 (n)
  • 86.98 (a)
chicken
(Gallus gallus)
Aves FRA10AC1 35
  • 72.44 (n)
  • 71.15 (a)
FRA10AC1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRA10AC1 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19509 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC147576 35
  • 68.05 (n)
  • 66.13 (a)
zebrafish
(Danio rerio)
Actinopterygii fra10ac1 35
  • 67.43 (n)
  • 68.63 (a)
fra10ac1 36
  • 61 (a)
OneToOne
wufc62g03 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010729 35
  • 50.2 (n)
  • 46.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16890 35
  • 48.78 (n)
  • 45.06 (a)
CG16890 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C08H9.16 36
  • 36 (a)
OneToOne
CELE_C08H9.16 35
  • 53.43 (n)
  • 41.46 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G15030 35
  • 58.19 (n)
  • 54.34 (a)
rice
(Oryza sativa)
Liliopsida Os11g0639000 35
  • 54.35 (n)
  • 47.83 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14549 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3424 36
  • 47 (a)
OneToOne
Species with no ortholog for FRA10AC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRA10AC1 Gene

ENSEMBL:
Gene Tree for FRA10AC1 (if available)
TreeFam:
Gene Tree for FRA10AC1 (if available)

Paralogs for FRA10AC1 Gene

Selected SIMAP similar genes for FRA10AC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FRA10AC1: view

No data available for Paralogs for FRA10AC1 Gene

Variants for FRA10AC1 Gene

Sequence variations from dbSNP and Humsavar for FRA10AC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs726817 - 93,700,060(+) CACAG(C/T)GTTCA missense, reference, nc-transcript-variant
rs726818 -- 93,700,382(+) CAGGC(C/T)TAAAA intron-variant
rs729122 -- 93,690,891(+) TGAAC(A/G)TTATT intron-variant
rs747210 -- 93,691,326(-) CAGTG(A/G)TGCAT intron-variant
rs767701 -- 93,685,174(+) AATTT(G/T)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FRA10AC1 Gene

Variant ID Type Subtype PubMed ID
nsv522686 CNV Loss 19592680
esv29301 CNV Loss 19812545

Relevant External Links for FRA10AC1 Gene

HapMap Linkage Disequilibrium report
FRA10AC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRA10AC1 Gene

Disorders for FRA10AC1 Gene

Relevant External Links for FRA10AC1

Genetic Association Database (GAD)
FRA10AC1
Human Genome Epidemiology (HuGE) Navigator
FRA10AC1
genes like me logo Genes that share disorders with FRA10AC1: view

No data available for UniProtKB/Swiss-Prot for FRA10AC1 Gene

Publications for FRA10AC1 Gene

  1. Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein. (PMID: 15203205) Sarafidou T. … Gecz J. (Genomics 2004) 2 3 4 23
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FRA10AC1 Gene

  • antibodies-online proteins for FRA10AC1
  • antibodies-online antibodies for FRA10AC1
  • antibodies-online kits for FRA10AC1

Sources for FRA10AC1 Gene

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